Liver Cirrhosis – Pipeline Review, H1 2012

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					                    Liver Cirrhosis – Pipeline Review, H1 2012


                                                                                          Reference Code: GMDHC1843IDB
                                                                                              Publication Date: April 2012




Liver Cirrhosis – Pipeline Review, H1 2012                                                    GMDHC1843IDB / Pub April 2012
© Global Markets Direct. This report is a licensed product and is not to be photocopied                             Page(1)
Liver Cirrhosis – Pipeline Review, H1 2012




Table of Contents
Table of Contents ............................................................................................................................................................................... 2
    List of Tables ................................................................................................................................................................................. 5
    List of Figures ................................................................................................................................................................................ 5
Introduction......................................................................................................................................................................................... 6
    Global Markets Direct Report Coverage ........................................................................................................................................ 6
Liver Cirrhosis Overview..................................................................................................................................................................... 7
Therapeutics Development................................................................................................................................................................. 8
    An Overview of Pipeline Products for Liver Cirrhosis .................................................................................................................... 8
Liver Cirrhosis Therapeutics under Development by Companies ..................................................................................................... 10
Liver Cirrhosis Therapeutics under Investigation by Universities/Institutes ...................................................................................... 11
Late Stage Products ......................................................................................................................................................................... 13
    Comparative Analysis .................................................................................................................................................................. 13
Mid Clinical Stage Products.............................................................................................................................................................. 14
    Comparative Analysis .................................................................................................................................................................. 14
Early Clinical Stage Products ........................................................................................................................................................... 15
    Comparative Analysis .................................................................................................................................................................. 15
Pre-Clinical Stage Products.............................................................................................................................................................. 16
    Comparative Analysis .................................................................................................................................................................. 16
Liver Cirrhosis Therapeutics – Products under Development by Companies ................................................................................... 17
Liver Cirrhosis Therapeutics – Products under Investigation by Universities/Institutes .................................................................... 18
Companies Involved in Liver Cirrhosis Therapeutics Development.................................................................................................. 19
    Stelic Institute & Co. .................................................................................................................................................................... 19
    Stempeutics Research Private Limited ........................................................................................................................................ 20
Liver Cirrhosis – Therapeutics Assessment ..................................................................................................................................... 21
    Assessment by Monotherapy Products ....................................................................................................................................... 21
    Assessment by Combination Products ........................................................................................................................................ 22
    Assessment by Route of Administration ...................................................................................................................................... 23
    Assessment by Molecule Type .................................................................................................................................................... 25
Drug Profiles..................................................................................................................................................................................... 27
    STNM04 - Drug Profile ................................................................................................................................................................ 27
         Product Description................................................................................................................................................................. 27
         Mechanism of Action ............................................................................................................................................................... 27
         R&D Progress ......................................................................................................................................................................... 27
    Sorafenib - Drug Profile ............................................................................................................................................................... 28
         Product Description................................................................................................................................................................. 28
         Mechanism of Action ............................................................................................................................................................... 28
         R&D Progress ......................................................................................................................................................................... 28
    Autologous CD133 + Stem Cells - Drug Profile ........................................................................................................................... 30
         Product Description................................................................................................................................................................. 30
         Mechanism of Action ............................................................................................................................................................... 30
         R&D Progress ......................................................................................................................................................................... 30
    Torisel - Drug Profile.................................................................................................................................................................... 31



Liver Cirrhosis – Pipeline Review, H1 2012                                                                                                         GMDHC1843IDB / Pub April 2012
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                                                                                   Page(2)
Liver Cirrhosis – Pipeline Review, H1 2012




        Product Description................................................................................................................................................................. 31
        Mechanism of Action ............................................................................................................................................................... 31
        R&D Progress ......................................................................................................................................................................... 31
    Lenograstim + Haematopoietic Stem Cells - Drug Profile............................................................................................................ 32
        Product Description................................................................................................................................................................. 32
        Mechanism of Action ............................................................................................................................................................... 32
        R&D Progress ......................................................................................................................................................................... 32
    Nobelzin - Drug Profile ................................................................................................................................................................ 33
        Product Description................................................................................................................................................................. 33
        Mechanism of Action ............................................................................................................................................................... 33
        R&D Progress ......................................................................................................................................................................... 33
    Bone Marrow Derived CD133+ Stem Cells Transplantation - Drug Profile .................................................................................. 34
        Product Description................................................................................................................................................................. 34
        Mechanism of Action ............................................................................................................................................................... 34
        R&D Progress ......................................................................................................................................................................... 34
    Umbilical Cord Mesenchymal Stem Cells - Drug Profile .............................................................................................................. 35
        Product Description................................................................................................................................................................. 35
        Mechanism of Action ............................................................................................................................................................... 35
        R&D Progress ......................................................................................................................................................................... 35
    Allogenic Bone Marrow Stem Cells Transplant - Drug Profile ..................................................................................................... 36
        Product Description................................................................................................................................................................. 36
        Mechanism of Action ............................................................................................................................................................... 36
        R&D Progress ......................................................................................................................................................................... 36
    Autologous Bone Marrow Mesenchymal Stem Cells Transplant - Drug Profile ........................................................................... 37
        Product Description................................................................................................................................................................. 37
        Mechanism of Action ............................................................................................................................................................... 37
        R&D Progress ......................................................................................................................................................................... 37
    Umbilical Cord Mesenchymal Stem Cells - Drug Profile .............................................................................................................. 38
        Product Description...
				
DOCUMENT INFO
Description: Liver Cirrhosis - Pipeline Review, H1 2012', provides an overview of the Liver Cirrhosis therapeutic pipeline. This report provides information on the therapeutic development for Liver Cirrhosis , complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Liver Cirrhosis . 'Liver Cirrhosis - Pipeline Review, H1 2012' is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team.
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Global Markets Direct is a leading provider of global business intelligence and market analysis. It publishes a range of high quality company and market reports created by its large research and analysis capability and drawing from its extensive unique databases of industry-specific information. Global Markets Direct has a broad range of coverage over key market segments. It has a global scope, covering a broad range of countries constituting more than 90% of global revenues in each of the industries it covers. With a large dedicated research and analysis capability, Global Markets Direct employs rigorous primary and secondary research techniques in developing unique data sets and research materials. Its status as an independent research company allows Analysts to conduct trade interviews with key industry players. Access to unique databases of in-house market information further strengthens research and analysis capabilities. Materials are reviewed shaped by an expert panel of leading industry figures and representatives from key players in the relevant industries