Mindray BS 200 Trouble Shooting by HC120522192356

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    Trouble Shooting

                       Diego Fang
          International Customer Service Dept.
                    Mindray Co., Ltd.
1 Trouble Shooting Flow
                                   Yes


                         Visible Trouble               Record      error            Locate the source with
Customer                                          No
                   (Mechanical stopping/noise          messages on the              the instruction of Service
s
complaints               /liquid leakage               Error Log report             Manual
                           /bad smell)




                                                                              Yes
                                                                                            Have
                                                                                            spare
                                                                                            parts?

                                                                                                     No
                                                 No


                                                          Repair or replace               Ask for RMA
             End                           Tes                                            number from
                                                          defective parts
                             Yes           t                                              mindray
                                           OK
                                           ?


                                                          Get new parts                     Return defective
                                                                                                parts
2 Error Description
2.1 Error Code Classification
   50000-XX-XX: PC software error
   10064-XX-XX: Main unit error
   10068-XX-XX: Sample unit error
   10069-XX-XX: Reagent unit error
   10067-XX-XX: Mixing unit error
   10066-XX-XX: Temperature control unit error
   10065-XX-XX:
         Reaction tray and photoelectric unit error
   Other: Alarm information
2.2 Error Level

          Warning
          Pause
          Stop
          Emergency stop
          Test forbidden
          Startup refusal
2.3 Error Code List



     Refer to Chapter 6 of Service Manual
3 Judging Errors
on the Reaction Curve
3.1 Reaction Curve

   The BS-200 analyzer features in its reaction
    curve. The curve and reaction data shows the
    whole reaction process to engineers and
    customers, which enables users to find and
    solve problems more easily. Causes for
    almost all result-related errors can be found
    on the reaction curve.
    3.2 Example of Reaction Curve
    (GGT)




                                F
               C         E
    A
        B
0


                     D
     3.3 Description
   As shown in the reaction curve above, the vertical axis indicates
    the absorbance (real value = value in this curve/10000).The
    intervals on the vertical axis of the reaction curve is not fixed.
   The horizontal axis indicates the measuring cycle, which is 16
    seconds for the BS-200 analyzer.
   A normal double-reagent reaction curve is usually divided into 6
    phases:
        A: time when R1 is added;
        B: time when R1 is preheated;
        C: time when sample is added;
        D: incubation time of sample and R1;
        E: time when R2 is added;
        F: reaction time.
3.4 Phase Description
    Phase A: Time When R1 Is Added



                      The point 0 indicates the cuvette blank
                      (which is considered as the referenced
                      absorbance for calculating ). In other
                      words,calculating absorbance = real
    0:cuvette blank
                      absorbance – cuvette blank.

0
Phase A: Time When R1 Is Added




      In the first cycle, R1 is added into the
       reaction cuvette, so the absorbance
      value here is the reagent blank of R1.
Phase A: Time When R1 Is Added




         A:Usually it ranges from 12000
         to 20000 (R1 of ALT)



      Absorbance values at Point A vary with different reagents. If
        the absorbance is much smaller than the value specified in
        the reagent instructions, the reagent may have lapsed. On
       the other hand, if the absorbance at Point A exceeds 50000
      (except for reagent for CO2), visually check whether there is
            any contamination or bubble in the reaction cuvette.
Phase B: Time When R1 Is Preheated




 B:Usually, absorbance
 does not change when
 the reagent is heated.
Phase B: Time When R1 Is Preheated




     Absorbance values of some reagents
     may have a increase/decrease of
     about 200 (0.02A).
Phase B: Potential Problems

   The normal fluctuation of absorbance
    between two continuous cycles is no more
    than 50. Otherwise there may be problems
    as below:
    •Bubbles or contamination in cuvette. In this case,
    the absorbance fluctuates in some tests, but not all
    tests.
    •The photoelectric conversion time matches the
    optical path not well. Observed in all tests for a
    specific wavelength.
    •The optical path is not stable such as an aged lamp.
Phase C: Time When Sample Is Added




   Showing the sample is
   added into the reaction
   cuvette.
Phase C: Potential Problems
   Possible causes for
    inconsistent absorbance
    values:
       Liquid dropping from
        probe;
       level detection failure for
        sample;                       In the same reduplicate
       fluid tubing leakage;          tests,different sample
       malfunction of the mixing
        bar;
                                       volume makes different
       over high position of the      absorbance on point C.
        mixing bar;
       unfixed position of the
        sample syringe.
Phase D: Incubation Time




    The reaction curve in this
   If fluctuation of absorbance exceeds
    phase is supposed to be
   50 between two continuous cycles,
    smooth or changing smoothly.
   check whether the mixing bar strikes
   the cuvette.
     Phase E: Time When R2 Is Added
   Similar situation as on point A and point C.
   Point E is also considered as the starting time of the reaction in
    the software.
   The possible problems here may be:
      Failure of adding R2;

      Bubbles or contamination with R2;

      Mixing bar strikes the cuvette.
Phase F: Reaction Time




                         Kinetic
         Endpoint        Decline
         Incline
Phase F: Potential Problems
 Most problems here will appear somewhere on the same
 reaction curve, and the causes are also similar. Such as the
 fluctuation caused by mixing bar ,or insufficient response as
 a result of the LLD failure.

    The impact of R2 may be considered
    when there is nothing abnormal on
    the other parts of the reaction curve.
3.5 Reaction Curve Review
   Even all the problems of the instruments and the reagents will
    result in an abnormal reaction curve. But some abnormal
    reaction curves seem normal.
                                       Different reaction type, different
                                        curve shape. So a nearly
                                        invisible fluctuation here may
                                        impact other tests much. Watch
                                        the instruction of the reagent
                                        carefully.
How to know?
                                Repeat the tests is very
                                 important. It can help you find
                                 the difference of the reaction
                                 curves. That is where the
                                 problems are.
4 Abnormal Test Result


     All results abnormal;
     Item results abnormal;
     Accidental results abnormal.


      Application of reaction curve!
    4.1 All Results Abnormal

   Symptoms:
       All results are low;
       Some are high, and some are low, resulting in bad
        repeatability.
 Practice:All Results Low
    How do you think about the reaction curve like if
     there are:

 The added sample and reagent is
insufficient (due to blocked probe,
fluid tubing leakage and/or syringe
leakage);


 The reaction is not thorough enough (because the mixing
bar is too high, and/or the mixing bar does not work).
   Practice:Some High,Some Low
• How do you think about the reaction curve like if :

          The mixing bar strikes the
           cuvette;
    Reagent usually has bubbles;

    The lamp is aged, the filter is aged, the
   photometric system is dirty, and/or the
   photoelectric conversion position is incorrect.
4.2 Item Results Abnormal
     In case of such an error, check the
        repeatability of the test.


     Find the rules on the reaction curves.


  The specific reagent deteriorated;
  Optical path problems of the specific wavelength;
  Photoelectric conversion position problems of the
 specific wavelength;
  Wrong calibration.
4.3 Accidental Results Abnormal
                     If the results are normal
                      in the repeated tests, the
                      possible cause is dirty
                      reaction cuvette or
                      bubbles aspirated into
                      the reagent probe.
                     If the results are still
                      abnormal, the possible
                      cause exist in the sample.
5 Liquid Level Detection(LLD) Error


   There are three LLD errors:

       LLD error in reagent disc;
       LLD error in sample disc;
       LLD error in washing pool.
          5.1 LLD Error: Reagent liquid level

    The probe fails to detect the reagent liquid level :
    A) Liquid level detection signal error
       Symptom: The detection indicator is off or always on.
       Abnormal assembly: Main control board or connection cable (The 12V
     working voltage is unavailable); reagent probe(broken or over high
     position); disabled LLD board.
    B) Transmission error
       Symptom: There is an alarm even when the detection indicator is on.
       Abnormal assembly: Probe connection cable is disconnected or in ill
     contact.
    C) Processing error
        Symptom: The indicator is on, and the connection cable is enabled.
        Abnormal assembly: Main control board.
    5.2 LLD Error: Sample level
   Two symptoms :
        A:failing to detect liquid level in sample tray;
        B:failing to detect liquid level in reaction tray.

                                 The same causes as
Both A and B:                    that of the reagent
                                 part(chapter 5.1)
                          No/insufficient        The probe mistakes to
     Only B:              reagent in the         detect the liquid level.
                          cuvette
    5.3 LLD Error of The Probe in Washing
                     Pool

   Two symptoms : No water in washing pool; water
    available in washing pool.
   No water in washing pool
    The distill water container is empty (the sensor is disabled);
    The exterior-washing pump is disabled (no water in all pools);
    The tubing is blocked (single-way valve blocked, 3-way connector
    blocked);
    The tubing is disconnected.
   Water available in washing pool
    The same as that of the probe failing to detect liquid level in the
    reagent part.
5.4 LLD Error Caused by Little Tubes
   The capacity of liquid
    aspirated only depend
    on the depth of the
    probe under the liquid
    level.
   Different area of cross
    section, different
    capacity.
   Using little tube instead
    of standard tube will
    cause insufficient
    sample /reagent.
 6 Liquid Dropping From Probes


• Three possible causes:
   Fluid tubing leakage
   (syringe/connector/valve)
   LLD error
   Other problems (dirty probes/unqualified
   probe driver assembly and so on)
Cause1: Fluid Tubing Leakage
    Distinct symptoms:
     In this case, the liquid drop in a large scale, some
     of which are relatively big, and dropping happens
     even when the probes are still.
    Solution:
     Check the syringe piston/tubing connector/valves
     on the leaking side and repair/replace the
     defective ones.
      Cause2: LLD Error
   Distinct symptoms:
    In this case, most drops are found between the reaction
    tray and the washing pool.
   Solution:
      Correct the over high position of the rocker-arm;

      Be sure there is no bubble in the reagent bottle and the
        cuvette;
      Be sure that the probe is in the center while dispensing
        liquid;
      Tight the screw for fixing the syringe .



    Note:The probe will NOT detect liquid level in the
    reaction tray when add reagent.
   Cause3: Other Problems

A) Distorted probe tip
 Cause: The probe tip is distorted, resulting in carryover.
 Solution: Replace the probe.
B) Dirty exterior of the probe
Cause: Contaminated by samples, resulting in carryover.
 Solution: Clean or replace the probe.
C) Unqualified probe driver assemblies
 Cause: The probe driver assemblies are unqualified,
 resulting in severe jitters at the moment when the probe
 is rising.
 Solution: Replace the defective ones.
    7 Problems in Photoelectric Unit
Insufficient Light Intensity:
 A) Optical path
 Symptom: Low background of several wavelengths,
 specially of the short wavelengths.
 Solution: Clean the end face of the optical fiber. And
 increase the gain if it is too low yet.
 B) Aged lamp
 Symptom: Either of the background of the 340nm
 wavelength or reference wavelength is lower than 43000.
 Solution: Replace the lamp.
   Insufficient Light Intensity 2
C) Aged filter
Symptom: After the lamp is replaced, the
background of a certain wavelength is still very low.
Solution: Replace the defective pre-amplification
assembly.
D) Defective pre-amplification board
Symptom: The background of a certain wavelength
is nearly 0.
Solution: Replace the defective pre-amplification
board.
Photoelectric Conversion Position
Match Not Well

    B: Indicate the time of
    A/D converting.                 Cuvette center




                                                     Air between
 A: Photoelectric signal      Cuvette wall           cuvettes
 of a certain wavelength.
        8 Temperature Control Error

   Only the reagent preheating has an alarm.
    Causes:
       The preheating temperature transducer is disconnected;
       The preheating temperature transducer does not work;
       The preheating system is switched off.
   Both the reagent preheating and reaction tray
    have alarms.
    Causes:
       Temperature control parameters are lost.
Solution for This Error
   Monitoring the temperature curve;
   Correct the temperature control
    parameters using the Parameter
    Configuration List;
   Measuring the impedance of the
    temperature transducer, and replace
    the disabled one;
   Replace the heater.
 Summary
    Here we can only give you a suggestion on
     how to find the problems. Actually the
     problems you facing always result in
     multiform symptoms. Do observe the reaction
     curve carefully, and find out the roots of the
     errors. Most alarm information of the BS-200
     analyzer is obtained based on sensor signals,
     so it is necessary to learn the signal flows.
Note: Backup the important data and parameters
when you prepare to replace some parts.
Thanks!

								
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