2 Peptide Synthesis Principle and Fundamental Method by kp0vUawa

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Amino Acid and Peptide
1) Natural Amino Acid
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2) Zwitterion

2.1 Structure of Zwitterion
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2.2 Isoelectric Point (pI)




3) Synthesis of Amino Acid
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4) Peptide

4.1 Peptide Bond (Amide Bond)




  Conventional Drawing of Peptide




   Conformation of Peptide
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   Some Important Peptides




4.2 Peptide Synthesis (Principle and Fundamental Method)




     General Strategy
                             Protection           Coupling    Deprotection



     Protecting Group (PG)

                                               N-Protection
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BOC




Fmoc




C-Protection
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4.3 Automated Peptide Synthesis (Merrifield Method)
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5) Peptide

5.1 Protein Structure
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5.2 Primary Structure




5.3 Secondary Structure




                 -Helix   -Pleated Sheet
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5.4 Tertiary and Quaternary Structure

								
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