HMM scores.xls

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HMM scores.xls Powered By Docstoc
					QUERYTEXT                              model
                            SCORE-fullPSCORE-full model            PSCORE-local
                                                          SCORE-local
AGC_AKT__SK018_AKT1           369.84 2.70E-107              368.95 5.10E-107
AGC_AKT__SK020_AKT3           357.78 1.20E-103               356.9 2.20E-103
AGC_AKT__SK019_AKT2           354.89 8.70E-103                 354 1.60E-102
CAMK_CAMKL_MARK_SK215_MARK1   351.27 1.10E-101              350.38 2.00E-101
CAMK_CAMKL_AMPK_SK033_AMPKa2 348.87 5.60E-101               347.97 1.10E-100
CAMK_CAMKL_MARK_SK096_MARK3   348.63 6.70E-101              347.71 1.30E-100
CAMK_CAMKL_BRSK_SK598_BRSK1   345.95 4.30E-100              345.07 7.80E-100
CAMK_CAMKL_QIK_SK513_QIK      343.89 1.80E-99               342.95 3.40E-99
CAMK_CAMKL_MARK_SK120_MARK2    343.1 3.10E-99               342.14 6.00E-99
CAMK_CAMKL_QIK_SK604_SIK       342.5 4.70E-99               341.55 9.00E-99
CAMK_CAMKL_MARK_SK515_MARK4   340.95 1.40E-98               340.01 2.60E-98
CMGC_CDK_CDC2_SK068_CDK3       339.3 4.30E-98               338.36 8.20E-98
CAMK_CAMKL_QIK_SK501_QSK      338.92 5.60E-98               337.89 1.10E-97
Other_TTK__SK383_TTK          336.82 2.40E-97               335.92 4.50E-97
CAMK_CAMKL_AMPK_SK032_AMPKa1   333.9 1.80E-96               332.99 3.40E-96
Other_AUR__SK407_AurA         333.06 3.20E-96               332.17 6.00E-96
STE_STE20_1_SK246_MST3        331.67 8.50E-96               330.76 1.60E-95
AGC_RSK_RSK_SK338_RSK3        330.18 2.40E-95               329.25 4.50E-95
CAMK_CAMKL_NuaK_SK195_NuaK1    329.2 4.70E-95               328.24 9.10E-95
CAMK_CAMKL_NuaK_SK472_NuaK2   327.57 1.50E-94               326.62 2.80E-94
AGC_RSK_RSK_SK337_RSK2        327.35 1.70E-94               326.42 3.20E-94
CMGC_CDK_CDC2_SK067_CDK2       327.3 1.80E-94               326.31 3.50E-94
CAMK_CAMK_I__SK021_CaMKIg     327.04 2.10E-94               326.12 4.00E-94
STE_STE20_1_SK395_YSK1        325.38 6.60E-94               324.46 1.30E-93
CAMK_CAMKL_MELK_SK298_MELK    325.25 7.30E-94               324.18 1.50E-93
AGC_RSK_RSK_SK336_RSK1        325.02 8.50E-94               324.09 1.60E-93
AGC_RSK_p70_SK265_p70S6K      323.57 2.30E-93               322.69 4.30E-93
CAMK_CAMKL_LKB_SK208_LKB1     323.57 2.30E-93               322.68 4.30E-93
CAMK_CAMK_I__SK056_CaMKIa     322.89 3.70E-93               321.97 7.10E-93
Other_PLK__SK341_SAK          322.98 3.50E-93               321.93 7.30E-93
Other_ULK__SK450_AA018361     322.82 3.90E-93                321.9 7.40E-93
STE_STE20_MST_SK244_MST1      320.35 2.20E-92               319.35 4.30E-92
CAMK_CAMK_I__SK572_CKLiK      320.09 2.60E-92               319.16 4.90E-92
STE_STE20_5_SK348_SLK         319.36 4.30E-92               318.45 8.10E-92
TKL_RAF__SK324_RAF1            318.3 9.00E-92               317.35 1.70E-91
Other_PLK__SK353_SNK          317.83 1.20E-91                316.9 2.40E-91
STE_STE20_PAK_SK269_PAK3       317.7 1.40E-91                316.7 2.70E-91
STE_STE20_PAK_SK268_PAK2       316.6 2.90E-91               315.66 5.60E-91
AGC_NDR__SK500_NDR2           316.46 3.20E-91               315.58 5.90E-91
Other_ULK__SK199_Fused        316.11 4.10E-91               315.14 8.00E-91
STE_STE20_MST_SK245_MST2      315.92 4.70E-91               314.93 9.30E-91
Other_NEK__SK250_NEK1         314.51 1.20E-90                313.6 2.30E-90
STE_STE20_PAK_SK267_PAK1      314.11 1.60E-90                313.1 3.30E-90
TKL_MLK_MLK_SK356_MLK3        313.08 3.30E-90                312.2 6.20E-90
CMGC_CDK_CDC2_SK065_CDC2      313.06 3.40E-90               312.09 6.60E-90
CAMK_Trio__SK376_Trio         312.42 5.30E-90               311.52 9.80E-90
AGC_RSK_RSK_SK518_RSK4        311.76 8.30E-90               310.79 1.60E-89
TK_Src__SK357_SRC              311.5 1.00E-89               310.64 1.80E-89
STE_STE20_1_SK431_STLK2        310.5 2.00E-89               309.59 3.80E-89
Other_NEK__SK558_pNEK5        310.15 2.50E-89               309.23 4.80E-89
AGC_SGK__SK346_SGK            309.73 3.40E-89                308.8 6.50E-89
AGC_PKC_Delta_SK310_PKCt      309.75   3.40E-89   308.74   6.80E-89
AGC_PKA__SK300_PKACa          309.53   3.90E-89   308.57   7.60E-89
AGC_PKA__SK302_PKACg             309   5.70E-89   308.04   1.10E-88
Other_AUR__SK043_AurC         308.63   7.30E-89    307.6   1.50E-88
Other_PLK__SK316_CNK          308.34   9.00E-89   307.45   1.70E-88
AGC_RSK_p70_SK266_p70S6Kb     308.06   1.10E-88   307.16   2.00E-88
AGC_NDR__SK441_WART1          307.73   1.40E-88   306.82   2.60E-88
TKL_MLK_MLK_SK233_MLK2        306.52   3.20E-88   305.62   5.90E-88
TKL_MLK_MLK_SK232_MLK1        306.23   3.80E-88   305.35   7.10E-88
Other_ULK__SK387_ULK1         306.04   4.40E-88   305.13   8.30E-88
AGC_NDR__SK249_NDR            305.34   7.20E-88   304.45   1.30E-87
TKL_RAF__SK050_BRAF           304.94   9.40E-88      304   1.80E-87
AGC_PKC_Eta_SK270_PKC_eta     304.83   1.00E-87   303.93   1.90E-87
AGC_RSK_MSK_SK242_MSK1        304.77   1.10E-87   303.87   2.00E-87
AGC_PKC_Delta_SK305_PKCd      303.66   2.30E-87   302.72   4.40E-87
CAMK_CAMK_I__SK662_CaMKIb     303.71   2.20E-87    302.7   4.50E-87
AGC_PKA__SK301_PKACb          303.23   3.10E-87   302.26   6.00E-87
AGC_PKB__SK276_PDK1           303.12   3.30E-87   302.01   7.20E-87
STE_STE20_5_SK426_GEK2         302.5   5.10E-87   301.55   9.90E-87
AGC_SGK__SK525_SGK3           302.38   5.60E-87   301.47   1.00E-86
CAMK_CAMK_II__SK703_CaMKIId   301.36   1.10E-86   300.41   2.20E-86
CAMK_CAMKL_MAKV_SK502_MAK-V   301.23   1.20E-86   300.31   2.30E-86
CAMK_PHK__SK283_PHKg1         300.96   1.50E-86   300.05   2.80E-86
Other_NEK__SK421_pNEK7        300.89   1.60E-86   299.97   3.00E-86
CAMK_DAPK__SK716_DAPK3        300.45   2.10E-86   299.55   4.00E-86
CAMK_CAMKL_SNRK_SK625_SNRK    300.35   2.30E-86    299.4   4.40E-86
CAMK_CHK2__SK079_CHK2         300.17   2.60E-86   299.26   4.90E-86
CAMK_CAMKL_NIM1_SK449_NIM1    300.13   2.60E-86   299.08   5.50E-86
AGC_SGK__SK523_SGK2           299.55   4.00E-86   298.56   7.80E-86
CAMK_Unique__SK463_STK33      299.49   4.10E-86   298.55   7.90E-86
CAMK_DCAMKL__SK459_DCAMKL3    299.36   4.50E-86   298.47   8.40E-86
AGC_PKA__SK313_PRKX           299.34   4.60E-86   298.45   8.50E-86
CAMK_CAMK_I__SK061_CaMKIV     298.85   6.40E-86   297.86   1.30E-85
STE_STE20_4_SK427_KHS2        298.63   7.50E-86   297.74   1.40E-85
AGC_PKC_Eta_SK306_PKCe        298.28   9.50E-86   297.39   1.80E-85
AGC_PKC_Iota_SK308_PKCi       297.95   1.20E-85   297.05   2.20E-85
AGC_NDR__SK442_WART2          297.89   1.30E-85   296.98   2.30E-85
STE_STE11__SK224_MAP3K4       297.67   1.50E-85    296.8   2.70E-85
AGC_RSK_MSK_SK243_MSK2        297.18   2.00E-85   296.29   3.80E-85
TK_Src__SK393_YES             295.67   5.80E-85    294.8   1.10E-84
Other_EIFK__SK119_EIF2aK      295.56   6.30E-85    294.7   1.10E-84
STE_STE11__SK223_MAP3K3       295.41   7.00E-85   294.51   1.30E-84
CAMK_CAMK_II__SK058_CaMKIIb   295.44   6.80E-85    294.5   1.30E-84
AGC_PKN__SK318_PKN2           294.65   1.20E-84   293.75   2.20E-84
Other_PLK__SK315_PLK1         294.48   1.30E-84   293.58   2.50E-84
CAMK_CAMK_II__SK057_CaMKIIa   293.63   2.40E-84   292.66   4.70E-84
Other_AUR__SK406_AurB         293.06   3.60E-84   292.13   6.80E-84
Other_CAMKK__SK482_CAMKKb     292.76   4.40E-84   291.79   8.60E-84
AGC_PKN__SK317_PKN1           292.41   5.60E-84    291.4   1.10E-83
AGC_PKC_Iota_SK311_PKCz       292.13   6.80E-84   291.24   1.30E-83
CMGC_CDKL__SK361_CDKL5        291.41   1.10E-83   290.35   2.30E-83
Other_NEK__SK256_pNEK4        291.11   1.40E-83   290.21   2.60E-83
TKL_RAF__SK036_ARAF               291.01   1.50E-83   290.07   2.80E-83
CAMK_CAMK_II__SK060_CaMKIIg       291.02   1.50E-83   290.06   2.80E-83
CMGC_CDKL__SK203_CDKL1            289.88   3.20E-83   288.95   6.20E-83
CMGC_MAPK_Erk7_SK465_ERK7         289.67   3.70E-83   288.73   7.20E-83
CAMK_PHK__SK284_PHKg2              288.7   7.30E-83   287.78   1.40E-82
STE_STE20_3_SK438_ZC2             288.09   1.10E-82   287.03   2.30E-82
TK_Src__SK419_FRK                 287.67   1.50E-82   286.75   2.80E-82
CAMK_DCAMKL__SK063_DCAMKL1        287.63   1.50E-82   286.68   3.00E-82
Other_NEK__SK420_pNEK6            287.52   1.70E-82   286.57   3.20E-82
Other_NEK__SK252_NEK3             287.05   2.30E-82    286.1   4.40E-82
CAMK_DCAMKL__SK527_DCAMKL2        286.59   3.10E-82    285.7   5.80E-82
CMGC_CDK_CDK5_SK070_CDK5           286.6   3.10E-82   285.53   6.60E-82
CMGC_CDKL__SK466_CDKL4            285.54   6.50E-82   284.48   1.40E-81
AGC_MAST__SK196_MAST3             285.38   7.30E-82   284.37   1.50E-81
AGC_MAST__SK216_MAST205           284.69   1.20E-81   283.71   2.30E-81
CAMK_DAPK__SK103_DAPK1            284.56   1.30E-81   283.66   2.40E-81
Other_ULK__SK388_ULK2             284.34   1.50E-81    283.4   2.90E-81
CAMK_RSKb__zSK518b_zSK518b_RSK4   284.36   1.50E-81   283.36   3.00E-81
TKL_RIP__SK328_RIPK1              284.31   1.50E-81   283.33   3.00E-81
TK_Src__SK153_FYN                 283.92   2.00E-81   283.04   3.70E-81
Other_NEK__SK251_NEK2             283.95   2.00E-81   283.03   3.70E-81
STE_Unique__SK093_COT             283.94   2.00E-81   283.03   3.70E-81
AGC_PKG__SK073_CGK                283.95   2.00E-81   282.83   4.30E-81
CMGC_CDKL__SK202_CDKL2            283.77   2.20E-81   282.79   4.40E-81
CMGC_CDKL__SK509_CDKL3             283.6   2.50E-81   282.71   4.70E-81
CMGC_CDK_TAIRE_SK271_PCTAIRE1     281.76   9.00E-81    280.7   1.90E-80
TKL_MLK_MLK_SK691_pMLK4           281.61   9.90E-81   280.63   2.00E-80
AGC_PKC_Alpha_SK303_PKCa          281.46   1.10E-80   280.51   2.10E-80
Other_NEK__SK574_NEK11            281.34   1.20E-80   280.41   2.30E-80
CAMK_RSKb__zSK336b_zSK336b_RSK1   281.21   1.30E-80   280.18   2.70E-80
STE_STE20_4_SK191_KHS1            280.35   2.40E-80   279.43   4.50E-80
CAMK_PSK__SK322_PSKH1             279.68   3.80E-80   278.74   7.30E-80
CAMK_RSKb__zSK338b_zSK338b_RSK3   279.47   4.40E-80   278.53   8.40E-80
STE_STE20_1_SK428_OSR1            279.17   5.40E-80   278.23   1.00E-79
CAMK_RSKb__zSK242b_zSK242b_MSK1   278.06   1.20E-79   277.35   1.90E-79
AGC_PKC_Iota_SK702_PKCx           277.74   1.50E-79   276.84   2.70E-79
TK_DDR__SK400_DDR1                277.64   1.60E-79   276.69   3.00E-79
CAMK_TSSK__SK471_TSSK3            277.58   1.60E-79   276.67   3.10E-79
CAMK_MLCK__SK709_SGK085            277.2   2.10E-79   276.29   4.00E-79
STE_STE20_PAK_SK510_pPAK5         274.56   1.30E-78   276.11   4.50E-79
CAMK_DAPK__SK104_DAPK2            276.49   3.50E-79   275.51   6.80E-79
CAMK_RSKb__zSK337b_zSK337b_RSK2   276.39   3.70E-79   275.46   7.10E-79
CAMK_CAMKL_BRSK_SK015_BRSK2       204.13   2.10E-57   274.17   1.70E-78
STE_STE11__SK222_MAP3K2           274.64   1.20E-78   273.72   2.40E-78
CMGC_CDK_CDK4_SK071_CDK6          273.99   2.00E-78   273.04   3.80E-78
AGC_DMPK__SK331_ROCK1             273.91   2.10E-78   272.98   4.00E-78
STE_STE20_3_SK437_ZC1             273.99   2.00E-78    272.9   4.20E-78
STE_STE11__SK444_MAP3K9           273.29   3.20E-78   272.38   6.00E-78
STE_STE11__SK573_MAP3K8              273   3.90E-78   272.07   7.40E-78
STE_STE20_1_SK432_STLK3           272.96   4.00E-78   272.02   7.70E-78
AGC_DMPK__SK263_ROCK2              272.9   4.20E-78   271.99   7.90E-78
Other_NEK__SK476_NEK8             272.68   4.90E-78   271.73   9.40E-78
TK_Trk__SK378_TRKB               272.3   6.30E-78   271.32   1.20E-77
STE_STE20_3_SK439_ZC3           272.14   7.10E-78   271.05   1.50E-77
STE_STE20_4_SK048_GCK           271.73   9.40E-78   270.77   1.80E-77
TK_Trk__SK379_TRKC              271.47   1.10E-77   270.48   2.20E-77
CMGC_CDK_CDK7_SK055_CDK7        271.21   1.30E-77    270.2   2.70E-77
TK_Abl__SK006_ABL               270.95   1.60E-77   269.92   3.30E-77
STE_STE11__SK225_MAP3K5         267.99   1.30E-76   269.62   4.10E-77
TK_Src__SK206_LCK               270.32   2.50E-77   269.41   4.70E-77
TK_Src__SK164_HCK               270.24   2.60E-77   269.35   4.90E-77
TKL_LISK_LIMK_SK412_LIMK1       270.08   3.00E-77   269.19   5.40E-77
Other_CKII__SK088_CKIIa         270.02   3.10E-77   269.11   5.80E-77
AGC_MAST__SK345_SAST            269.56   4.20E-77   268.54   8.50E-77
CMGC_RCK__SK497_ICK             269.44   4.60E-77   268.27   1.00E-76
CMGC_CDK_TAIRE_SK272_PCTAIRE2    268.7   7.70E-77   267.61   1.60E-76
Other_CKII__SK089_CKIIa'        268.46   9.10E-77   267.57   1.70E-76
CMGC_CDK_CRK7_SK485_CRK7        268.45   9.10E-77   267.55   1.70E-76
CAMK_PSK__SK602_PSKH2           268.09   1.20E-76   267.18   2.20E-76
STE_STE20_TAO_SK435_SULU1       267.48   1.80E-76   266.47   3.60E-76
Other_CAMKK__SK697_CAMKKa       265.42   7.40E-76   266.32   4.00E-76
STE_STE20_TAO_SK436_SULU3       266.18   4.40E-76   265.23   8.50E-76
TK_Src__SK051_BRK               266.11   4.60E-76   265.14   9.00E-76
CMGC_MAPK_ERK_SK408_ERK5        266.04   4.80E-76    265.1   9.30E-76
TKL_MLK_MLK_SK504_sMLK4         265.93   5.20E-76   265.02   9.80E-76
TK_EGFR__SK118_EGFR              265.7   6.10E-76   264.77   1.20E-75
STE_STE20_4_SK170_HPK1          265.62   6.50E-76   264.71   1.20E-75
TK_Src__SK210_LYN               265.49   7.10E-76   264.59   1.30E-75
STE_STE20_NinaC_SK636_MYO3A     265.55   6.80E-76   264.48   1.40E-75
Other_CKII__SK750_CKIIar        265.08   9.50E-76   264.17   1.80E-75
STE_STE20_PAK_SK430_pPAK4       262.31   6.40E-75   264.15   1.80E-75
STE_STE11__SK681_MAP3K7         263.72   2.40E-75   264.11   1.80E-75
CMGC_MAPK_ERK_SK135_ERK2         264.9   1.10E-75   263.93   2.10E-75
AGC_PKN__SK511_PKN3             263.99   2.00E-75   262.98   4.00E-75
CAMK_PKD__SK480_PKD2            263.84   2.20E-75   262.82   4.50E-75
CAMK_MLCK__SK536_caMLCK         263.44   2.90E-75   262.52   5.60E-75
TK_Src__SK148_FGR               262.99   4.00E-75   261.93   8.40E-75
Other_MOS__SK237_MOS            262.66   5.00E-75   261.73   9.60E-75
AGC_DMPK__SK695_CRIK            262.71   4.90E-75   261.69   9.80E-75
CAMK_CASK__SK064_CASK           262.48   5.70E-75   261.47   1.10E-74
STE_STE11__SK221_MAP3K1         261.99   8.00E-75   261.01   1.60E-74
AGC_GRK__SK158_GPRK6            261.92   8.40E-75   260.95   1.60E-74
CMGC_CDK_CRK7_SK076_CHED        261.71   9.70E-75   260.82   1.80E-74
TK_DDR__SK410_DDR2              261.39   1.20E-74   260.47   2.30E-74
TK_Abl__SK037_ARG               261.42   1.20E-74   260.42   2.40E-74
CMGC_CDK_CDK4_SK069_CDK4        260.55   2.20E-74   259.59   4.20E-74
STE_STE20_PAK_SK429_pPAK6       260.54   2.20E-74   259.47   4.60E-74
CAMK_MLCK__SK231_smMLCK         260.32   2.60E-74   259.39   4.90E-74
TKL_MLK_TAK1_SK364_TAK1         260.24   2.70E-74   259.35   5.00E-74
CMGC_MAPK_p38_SK344_p38delta    260.23   2.70E-74   259.26   5.30E-74
AGC_PKG__SK075_cGMPKII          260.13   2.90E-74   258.99   6.40E-74
AGC_PKC_Alpha_SK304_PKCb        259.85   3.50E-74   258.85   7.10E-74
CMGC_RCK__SK211_MAK             259.04   6.20E-74   257.86   1.40E-73
CAMK_DAPK__SK486_DRAK1             259   6.40E-74   257.85   1.40E-73
CMGC_MAPK_p38_SK264_p38alpha      258.76   7.50E-74   257.74   1.50E-73
CMGC_CDK_CDK9_SK295_CDK9          258.73   7.70E-74   257.73   1.50E-73
STE_STE11__SK503_MAP3K6           254.83   1.10E-72   257.27   2.10E-73
TKL_MLK_LZK_SK398_LZK             257.04   2.50E-73   256.07   4.90E-73
TK_CCK4__SK411_CCK4               256.94   2.70E-73   256.05   4.90E-73
CAMK_TSSK__SK474_TSSK2            256.31   4.10E-73   255.31   8.20E-73
AGC_PKC_Alpha_SK307_PKCg          256.24   4.30E-73   255.27   8.40E-73
CAMK_CAMKL_CHK1_SK078_CHK1         255.7   6.30E-73   254.62   1.30E-72
TK_Tec__SK384_TXK                 255.27   8.50E-73   254.35   1.60E-72
AGC_PKA__SK320_PRKY               217.11   2.60E-61   254.21   1.80E-72
CMGC_MAPK_JNK_SK189_JNK2          255.16   9.10E-73   254.08   1.90E-72
CMGC_MAPK_JNK_SK190_JNK3          254.57   1.40E-72   253.58   2.70E-72
Other_NEK__SK470_NEK9             254.12   1.90E-72   253.15   3.70E-72
CAMK_TSSK__SK534_TSSK4            252.94   4.20E-72   251.99   8.20E-72
TK_EGFR__SK168_HER4               252.64   5.20E-72   251.66   1.00E-71
CMGC_MAPK_p38_SK343_p38gamma      252.62   5.30E-72   251.64   1.00E-71
AGC_MAST__SK701_MAST4             223.22   3.80E-63   251.37   1.30E-71
AGC_GRK__SK478_BARK2              251.62   1.10E-71   250.72   2.00E-71
TK_Fes__SK140_FER                 251.18   1.40E-71   250.23   2.80E-71
CMGC_MAPK_JNK_SK188_JNK1          251.16   1.50E-71   250.18   2.90E-71
TK_Tec__SK366_TEC                 251.02   1.60E-71   249.99   3.30E-71
CMGC_CDK_TAIRE_SK273_PCTAIRE3     250.64   2.10E-71   249.57   4.40E-71
CAMK_RSKb__zSK243b_zSK243b_MSK2   244.02   2.10E-69   247.87   1.40E-70
CMGC_CDK_CDK10_SK294_CDK10        248.83   7.40E-71   247.84   1.50E-70
CMGC_RCK__SK505_MOK               248.85   7.30E-71    247.8   1.50E-70
CMGC_MAPK_ERK_SK134_ERK1          248.74   7.80E-71   247.78   1.50E-70
TK_Fak__SK138_FAK                 247.91   1.40E-70    246.9   2.80E-70
Other_TLK__SK374_TLK2             247.74   1.60E-70   246.83   2.90E-70
AGC_DMPK__SK241_MRCKb             247.62   1.70E-70   246.67   3.30E-70
AGC_DMPK__SK112_DMPK2             247.31   2.10E-70   246.34   4.10E-70
AGC_GRK__SK045_BARK1A             246.58   3.50E-70    245.7   6.40E-70
TKL_MLK_LZK_SK110_DLK             245.29   8.50E-70   245.43   7.70E-70
CAMK_PKD__SK489_PKD3               246.2   4.60E-70    245.1   9.70E-70
CAMK_MAPKAPK_MNK_SK235_MNK1       245.83   5.90E-70   244.89   1.10E-69
AGC_GRK__SK157_GPRK5              245.47   7.50E-70   244.45   1.50E-69
TK_EGFR__SK166_HER2               245.18   9.20E-70   244.28   1.70E-69
CAMK_TSSK__SK524_SSTK             245.18   9.20E-70   244.23   1.80E-69
TK_Eph__SK123_EphA3               244.88   1.10E-69   243.96   2.10E-69
CMGC_CDK_PITSLRE_SK297_PITSLRE    244.88   1.10E-69   243.91   2.20E-69
AGC_YANK__SK624_YANK1              244.6   1.40E-69   243.64   2.70E-69
CMGC_MAPK_nmo_SK255_NLK           244.32   1.70E-69   243.26   3.50E-69
CAMK_TSSK__SK705_TSSK1            243.72   2.50E-69   242.72   5.10E-69
STE_STE20_TAO_SK362_SULU2         243.34   3.30E-69   242.41   6.30E-69
TK_FGFR__SK143_FGFR1              243.38   3.20E-69   242.37   6.50E-69
STE_STE20_NinaC_SK583_MYO3B        243.2   3.60E-69   242.05   8.10E-69
Other_DYRK_Dyrk1_SK114_DYRK1B     242.52   5.80E-69   241.48   1.20E-68
AGC_YANK__SK481_YANK2             242.42   6.20E-69   241.48   1.20E-68
TK_Trk__SK377_TRKA                242.38   6.40E-69   241.39   1.30E-68
CMGC_GSK__SK162_GSK3A             242.13   7.60E-69   241.05   1.60E-68
CMGC_GSK__SK163_GSK3B             242.09   7.90E-69      241   1.70E-68
TK_Src__SK049_BLK                 241.96   8.60E-69   240.92   1.80E-68
AGC_GRK__SK156_GPRK4              241.29   1.40E-68   240.27   2.80E-68
STE_STE7__SK239_MAP2K4          240.99   1.70E-68   240.07   3.20E-68
AGC_DMPK__SK299_PK428           240.93   1.80E-68   239.97   3.40E-68
CAMK_Trio__SK533_Trad           240.61   2.20E-68   239.65   4.20E-68
TK_Eph__SK125_EphA5             239.92   3.50E-68      239   6.70E-68
TK_Ret__SK326_RET               239.91   3.50E-68   238.85   7.40E-68
Other_DYRK_HIPK_SK495_HIPK2      239.6   4.40E-68    238.6   8.80E-68
CMGC_CDK_TAIRE_SK282_PFTAIRE1   239.46   4.90E-68   238.28   1.10E-67
TK_Eph__SK127_EphB1             239.14   6.10E-68   238.21   1.20E-67
AGC_GRK__SK327_RHODK            238.48   9.60E-68    237.6   1.80E-67
Other_DYRK_Dyrk2_SK115_DYRK2    237.81   1.50E-67   236.86   3.00E-67
TK_Tec__SK052_BTK               237.34   2.10E-67   236.42   4.00E-67
CAMK_MAPKAPK_MNK_SK236_MNK2      237.3   2.20E-67   236.35   4.20E-67
TKL_LISK_LIMK_SK207_LIMK2          234   2.10E-66   236.24   4.50E-67
CAMK_DAPK__SK487_DRAK2          236.97   2.70E-67   235.74   6.40E-67
CMGC_CDK_TAIRE_SK462_PFTAIRE2   236.32   4.30E-67   235.11   9.90E-67
TK_Eph__SK122_EphA2             235.16   9.50E-67   234.23   1.80E-66
TK_Eph__SK124_EphA4             234.82   1.20E-66   233.91   2.30E-66
TK_Eph__SK416_EphA7              234.7   1.30E-66   233.79   2.50E-66
TK_Eph__SK128_EphB2             234.57   1.40E-66   233.65   2.70E-66
CAMK_Trio__SK601_Obscurin       234.17   1.90E-66   233.14   3.90E-66
TK_FGFR__SK145_FGFR3            234.15   1.90E-66   233.12   3.90E-66
CAMK_MLCK__SK675_skMLCK         233.83   2.40E-66   232.93   4.50E-66
AGC_YANK__SK469_YANK3           233.77   2.50E-66   232.85   4.80E-66
TK_Musk__SK247_MUSK             233.75   2.50E-66   232.76   5.00E-66
TK_Tec__SK184_ITK               233.21   3.70E-66   232.22   7.40E-66
TK_FGFR__SK147_FGFR4            233.15   3.90E-66   232.13   7.80E-66
STE_STE20_3_SK440_ZC4           232.84   4.80E-66   231.79   9.90E-66
TK_FGFR__SK144_FGFR2            232.54   5.90E-66   231.55   1.20E-65
TK_Tie__SK367_TEK               232.46   6.20E-66   231.45   1.30E-65
Other_DYRK_Dyrk2_SK488_DYRK3    232.44   6.30E-66   231.45   1.30E-65
TK_Tec__SK417_BMX               232.26   7.20E-66   231.27   1.40E-65
CMGC_MAPK_p38_SK342_p38beta     232.33   6.80E-66   231.24   1.50E-65
STE_STE7__SK217_MAP2K1          231.64   1.10E-65   230.75   2.00E-65
TK_SEV__SK335_ROS               231.51   1.20E-65   230.59   2.30E-65
Other_NEK__SK645_NEK10          231.31   1.40E-65   230.41   2.60E-65
CMGC_MAPK_ERK_SK136_ERK3        230.16   3.10E-65   229.27   5.70E-65
Other_TLK__SK373_TLK1           230.15   3.10E-65   229.23   5.80E-65
TK_Met__SK227_MET               229.82   3.90E-65   228.88   7.40E-65
TK_Ack__SK009_ACK               229.38   5.20E-65   228.42   1.00E-64
TK_Src__SK425_SAD               228.95   7.10E-65   228.04   1.30E-64
Other_DYRK_Dyrk1_SK234_DYRK1A   228.04   1.30E-64   226.98   2.80E-64
AGC_DMPK__SK111_DMPK             227.8   1.60E-64   226.79   3.20E-64
TK_PDGFR__SK149_FLT3            227.45   2.00E-64   226.17   4.90E-64
Other_DYRK_HIPK_SK169_HIPK1     225.26   9.20E-64   224.25   1.80E-63
TK_Eph__SK646_EPHA6             224.03   2.10E-63   223.14   4.00E-63
TK_Csk__SK095_CSK               223.61   2.90E-63   222.68   5.50E-63
Other_EIFK__SK490_GCN2          223.38   3.40E-63   222.38   6.70E-63
TK_Axl__SK044_AXL               223.07   4.20E-63      222   8.70E-63
STE_STE7__SK218_MAP2K2          222.77   5.10E-63   221.86   9.70E-63
TK_Eph__SK126_EphA8             222.47   6.30E-63   221.57   1.20E-62
TK_InsR__SK178_INSR             222.55   6.00E-63   221.56   1.20E-62
TK_Fes__SK142_FES               222.28   7.20E-63   221.34   1.40E-62
TKL_STKR_Type_I_SK028_ALK4    221.54   1.20E-62   220.65   2.20E-62
TK_Eph__SK129_EphB3            220.2   3.10E-62   219.27   5.80E-62
TK_PDGFR__SK201_KIT           218.55   9.60E-62   217.39   2.10E-61
CAMK_CAMKL_PASK_SK499_PASK     217.7   1.70E-61   216.81   3.20E-61
Other_DYRK_HIPK_SK314_HIPK3   216.45   4.10E-61   215.45   8.20E-61
TK_PDGFR__SK094_CSFR          216.75   3.30E-61   215.44   8.30E-61
CAMK_MLCK__SK372_Titin        215.89   6.10E-61   214.94   1.20E-60
TKL_STKR_Type_I_SK029_ALK5    214.39   1.70E-60   213.47   3.20E-60
TK_InsR__SK174_IGF1R          214.48   1.60E-60   213.46   3.30E-60
TK_Fak__SK424_PYK2            214.25   1.90E-60   213.27   3.70E-60
TK_Eph__SK130_EphB4           214.09   2.10E-60   213.15   4.00E-60
CAMK_PIM__SK291_PIM1           213.7   2.80E-60    212.7   5.50E-60
STE_STE7__SK219_MAP2K5        213.37   3.50E-60   212.38   6.90E-60
TK_Met__SK332_RON              213.3   3.60E-60    212.3   7.30E-60
TKL_RAF__SK605_KSR2           212.77   5.30E-60   211.82   1.00E-59
TKL_MLK_HH498_SK494_HH498     212.27   7.40E-60   211.31   1.50E-59
Other_DYRK_Dyrk2_SK116_DYRK4  211.48   1.30E-59   210.48   2.60E-59
Other_NKF1__SK650_SBK         210.76   2.10E-59   209.77   4.20E-59
                              209.87
CAMK_MAPKAPK_MAPKAPK_SK214_MAPKAPK5    3.90E-59    209.6   4.70E-59
CMGC_CDK_CDK7_SK603_SGK149    210.55   2.40E-59   209.44   5.30E-59
AGC_GRK__SK578_GPRK7          210.22   3.10E-59   209.32   5.80E-59
TKL_LISK_TESK_SK368_TESK1     207.16   2.60E-58   209.31   5.80E-59
AGC_RSK_Unique_SK491_H19102   210.23   3.10E-59   209.24   6.10E-59
TK_Axl__SK386_TYRO3           209.61   4.70E-59   208.61   9.40E-59
TK_JakA__SK185_JAK1           208.88   7.80E-59   207.81   1.60E-58
STE_STE7__SK230_MAP2K7        208.68   8.90E-59   207.74   1.70E-58
CMGC_CDK_CDK8_SK443_SGK479    206.52   4.00E-58   207.71   1.80E-58
TK_PDGFR__SK274_PDGFRa        208.73   8.60E-59   207.56   1.90E-58
CMGC_CLK__SK090_CLK1          207.64   1.80E-58   206.71   3.50E-58
CMGC_CDK_CDK8_SK072_CDK8      205.05   1.10E-57   206.28   4.70E-58
TK_Eph__SK121_EphA1           207.26   2.40E-58   206.17   5.10E-58
                              207.01
CAMK_MAPKAPK_MAPKAPK_SK213_MAPKAPK3    2.80E-58   205.99   5.80E-58
CMGC_MAPK_ERK_SK137_ERK4      205.47   8.30E-58   205.36   8.90E-58
CAMK_PIM__SK200_PIM3          205.44   8.40E-58   204.43   1.70E-57
TK_VEGFR__SK150_FLT1          204.81   1.30E-57   203.77   2.70E-57
                              203.13
CAMK_MAPKAPK_MAPKAPK_SK212_MAPKAPK2    4.20E-57   202.75   5.50E-57
TK_InsR__SK183_IRR            203.62   3.00E-57    202.6   6.10E-57
TKL_IRAK__SK257_IRAK4         192.33   7.50E-54    202.4   6.90E-57
TK_Csk__SK418_CTK             202.37   7.10E-57   201.46   1.30E-56
Other_EIFK__SK496_HRI         202.12   8.50E-57   201.15   1.70E-56
Other_Wnk__SK508_Wnk1         202.01   9.10E-57   201.03   1.80E-56
TKL_STKR_Type_I_SK030_ALK6    201.89   9.90E-57   201.02   1.80E-56
TK_JakA__SK186_JAK2           201.52   1.30E-56   200.97   1.90E-56
STE_STE7__SK238_MAP2K3        201.42   1.40E-56   200.39   2.80E-56
TK_Ror__SK333_ROR1            201.13   1.70E-56    200.2   3.20E-56
TK_PDGFR__SK275_PDGFRb        201.25   1.50E-56   200.18   3.20E-56
STE_STE7__SK220_MAP2K6         200.8   2.10E-56   199.79   4.20E-56
Other_NAK__SK422_sNEK6         200.6   2.40E-56   199.73   4.40E-56
Gcyc_GCyc__SK171_HSER         198.87   8.00E-56   197.99   1.50E-55
AGC_RSK_p70_SK670_SGK351       96.67   4.70E-25   197.97   1.50E-55
CMGC_CLK__SK091_CLK2          198.78   8.60E-56   197.81   1.70E-55
TK_JakA__SK187_JAK3           197.55   2.00E-55   196.54   4.00E-55
Other_EIFK__SK281_PEK             197.32   2.40E-55   196.31   4.70E-55
TK_Tie__SK370_TIE                 195.89   6.30E-55   194.82   1.30E-54
TKL_RAF__SK205_KSR                195.73   7.10E-55   194.79   1.40E-54
AGC_MAST__SK455_MASTL              145.3   1.10E-39   194.44   1.70E-54
TKL_STKR_Type_I_SK027_ALK3        195.35   9.20E-55    194.4   1.80E-54
TK_VEGFR__SK151_FLT4              193.81   2.70E-54   192.75   5.60E-54
TK_VEGFR__SK402_KDR               193.64   3.00E-54   192.61   6.20E-54
TKL_MLK_ILK_SK177_ILK             193.04   4.60E-54   192.16   8.40E-54
Other_Wnk__SK641_pWnk3               193   4.70E-54   192.03   9.20E-54
Other_NAK__SK704_BIKE             192.89   5.10E-54   191.96   9.70E-54
TK_Axl__SK226_MER                 192.99   4.70E-54   191.91   1.00E-53
TK_JakA__SK385_TYK2               189.74   4.50E-53   191.69   1.20E-53
CAMK_Trio__zSK537b_zSK537b_SPEG    192.2   8.20E-54   191.23   1.60E-53
TKL_STKR_Type_I_SK405_ALK7        189.99   3.80E-53   189.03   7.40E-53
Other_IRE__SK182_IRE1             189.82   4.30E-53   188.86   8.30E-53
Other_NAK__SK155_GAK              187.95   1.60E-52   187.05   2.90E-52
Other_IKK__SK175_IKKa             176.42   4.60E-49   186.54   4.10E-52
CMGC_CLK__SK484_CLK4              185.71   7.30E-52   185.76   7.10E-52
Other_Wnk__SK016_Wnk2             185.91   6.40E-52   184.94   1.30E-51
Other_ULK__SK452_AA215311         185.86   6.60E-52   184.92   1.30E-51
Other_DYRK_HIPK_SK582_HIPK4       173.87   2.70E-48   184.59   1.60E-51
TK_Ror__SK334_ROR2                185.15   1.10E-51    184.2   2.10E-51
CAMK_Trio__SK537_SPEG             184.68   1.50E-51   183.69   3.00E-51
TK_Alk__SK024_ALK                 184.67   1.50E-51   183.57   3.20E-51
TK_Syk__SK363_SYK                 182.98   4.90E-51   181.88   1.00E-50
Other_IKK__SK176_IKKb             160.31   3.30E-44   181.45   1.40E-50
TK_EGFR__SK167_HER3               180.92   2.00E-50   179.94   4.00E-50
Other_Wnk__SK588_pWnk4            180.82   2.20E-50   179.84   4.30E-50
Other_IRE__SK498_IRE2             180.82   2.20E-50    179.8   4.40E-50
CMGC_CLK__SK092_CLK3                 180   3.90E-50   179.01   7.60E-50
Other_ULK__SK493_H85389           178.42   1.10E-49   178.79   8.90E-50
Other_NAK__SK506_MPSK1            178.57   1.00E-49   177.57   2.10E-49
TKL_STKR_Type_I_SK026_ALK2        178.49   1.10E-49   177.45   2.30E-49
TKL_RIP__SK330_RIPK3              174.33   2.00E-48   173.92   2.60E-48
TK_Ack__SK375_TNK1                174.81   1.40E-48   173.91   2.60E-48
TKL_STKR_Type_I_SK025_ALK1        174.21   2.10E-48   173.33   3.90E-48
TK_Syk__SK397_ZAP70               172.48   7.10E-48   171.37   1.40E-47
TK_Lmr__SK415_LMR3                171.23   1.70E-47   170.23   3.00E-47
TK_Alk__SK209_LTK                 169.97   4.00E-47   169.03   6.70E-47
CAMK_PIM__SK292_PIM2              169.92   4.20E-47   168.83   7.60E-47
Other_WEE__SK248_MYT1             169.36   6.10E-47   168.42   1.00E-46
CMGC_CDK_CDC2_SK483_CCRK          168.51   1.10E-46   167.56   1.80E-46
TKL_RIP__SK546_ANKRD3             166.97   3.20E-46   165.82   5.50E-46
TKL_LRRK___SK698_LRRK1            164.03   2.50E-45   162.86   3.80E-45
Other_Unique__SK516_Not_RIP4      162.78   5.90E-45   162.86   3.80E-45
Other_DYRK_PRP4_SK321_PRP4        163.36   3.90E-45   162.33   5.40E-45
STE_Unique__SK253_NIK             159.52   5.60E-44   161.13   1.20E-44
TKL_RIP__SK329_RIPK2                 161   2.00E-44   159.94   2.60E-44
Other_CDC7__SK066_CDC7            160.19   3.50E-44   159.13   4.40E-44
TK_Lmr__SK413_LMR1                157.14   2.90E-43   156.14   3.10E-43
TKL_STKR_Type_II_SK369_TGFbRII    152.91   5.50E-42   153.99   1.30E-42
Other_WEE__SK391_Wee1             154.02   2.50E-42   153.06   2.40E-42
Other_IKK__SK193_IKKe               144.82   1.50E-39   151.63   6.00E-42
Other_NKF1__SK581_SGK069            152.14   9.40E-42   151.12   8.50E-42
STE_STE7__SK540_MAP2K2psu           151.98   1.00E-41   151.07   8.80E-42
Other_IKK__SK531_TBK1                142.2   9.20E-39   149.09   3.20E-41
TKL_STKR_Type_II_SK365_T-ALK        148.66   1.00E-40   148.04   6.40E-41
Other_WEE__SK723_Wee1b              148.63   1.10E-40    147.7   8.00E-41
TKL_LISK_TESK_SK532_TESK2           146.49   4.70E-40   147.58   8.60E-41
Other_PLK__SK522_SGK384             138.02   1.70E-37   147.05   1.20E-40
STE_STE20_STLK_SK433_STLK5          146.64   4.20E-40   145.71   2.90E-40
TKL_STKR_Type_II_SK010_ACTR-II       139.8   4.90E-38   141.28   5.40E-39
TKL_RIP__SK658_SGK288               137.81   1.90E-37   140.05   1.20E-38
TK_Unique__SK530_SuRTK106           140.51   3.00E-38   139.79   1.40E-38
TKL_IRAK__SK179_IRAK1                121.9   1.20E-32   138.94   2.50E-38
Other_TOPK__SK529_TOPK               133.6   3.60E-36   138.85   2.70E-38
Other_TBCK__SK664_TBCK              120.51   3.10E-32   138.06   4.50E-38
TK_Ryk__SK340_RYK                   138.69   1.10E-37   137.66   5.80E-38
CAMK_Unique__SK492_H60215            35.19   1.20E-08   137.64   5.90E-38
TK_Eph__SK627_EphA10                136.86   3.70E-37   135.94   1.80E-37
CKI_CKI__SK087_CKIg3                121.97   1.10E-32   135.28   2.80E-37
TKL_LRRK___SK690_LRRK2              131.11   2.00E-35   133.05   1.20E-36
CKI_CKI__SK647_CKIg1                123.04   5.40E-33   131.99   2.40E-36
STE_STE20_STLK_SK434_STLK6          131.94   1.10E-35   131.07   4.40E-36
TK_Eph__SK132_EphB6                  131.9   1.20E-35   130.85   5.00E-36
CAMK_Trb__SK014_Trb1                121.02   2.20E-32   130.18   7.90E-36
Other_ULK__SK457_AA311714           127.56   2.30E-34    128.5   2.40E-35
CKI_CKI__SK541_CKIa2                112.75   6.70E-30   128.47   2.40E-35
CAMK_Trb__SK160_Trb2                114.36   2.20E-30    126.9   6.70E-35
Other_SRPK__SK358_SRPK1             127.39   2.60E-34   126.44   9.10E-35
TKL_STKR_Type_II_SK228_MISRII       127.21   3.00E-34   126.28   1.00E-34
CAMK_Trio__zSK601b_zSK601b_Obscurin 126.34   5.50E-34   126.01   1.20E-34
CKI_CKI__SK086_CKIg2                 113.7   3.50E-30   125.73   1.50E-34
CKI_CKI__SK082_CKIa                 111.02   2.20E-29   125.26   2.00E-34
Other_SRPK__SK359_SRPK2             123.67   3.50E-33   122.75   1.00E-33
CKI_CKI__SK083_CKId                 112.01   1.10E-29    122.7   1.10E-33
TKL_STKR_Type_II_SK011_ACTR-IIB4     122.1   1.00E-32   121.77   2.00E-33
STE_STE20_STLK_SK747_STLK6r         117.74   2.10E-31   121.56   2.30E-33
CKI_CKI__SK084_CKIe                 109.38   7.00E-29   121.04   3.20E-33
Other_SRPK__SK507_MSSK1             120.22   3.80E-32   119.29   1.00E-32
TK_Lmr__SK414_LMR2                  118.38   1.40E-31   117.34   3.60E-32
CKI_CKIL__SK453_CKIL2               110.43   3.40E-29   116.68   5.50E-32
CAMK_Unique__SK062_VACAMKL          114.59   1.90E-30   113.74   3.80E-31
STE_STE20_STLK_SK631_SGK211         114.25   2.40E-30   113.36   4.90E-31
Other_Unique__SK661_KIS             113.26   4.80E-30   112.64   7.80E-31
CKI_CKIL__SK526_CKIL1               104.62   1.90E-27   109.67   5.50E-30
TKL_Unique__SK458_MLKL              104.06   2.80E-27   107.59   2.10E-29
TKL_IRAK__SK181_IRAK-M               87.35   3.00E-22   100.62   2.10E-27
Other_NKF1__SK592_SGK110             99.38   7.20E-26     98.4   8.90E-27
TK_JakB__zSK185b_zSK185b_Jak1        98.96   9.60E-26    97.91   1.20E-26
AGC_RSKL__SK517_RPS6KC1              51.47   1.90E-11    93.07   2.90E-25
Other_Unique__SK521_SGK071           86.89   4.10E-22    91.45   8.50E-25
TK_JakB__zSK186b_zSK186b_Jak2        91.97   1.20E-23    90.96   1.20E-24
CAMK_Trb__SK694_Trb3                 64.46   2.30E-15     86.2   2.70E-23
TK_JakB__zSK385b_zSK385b_Tyk2        86.03 7.50E-22     85.04   5.70E-23
TKL_IRAK__SK180_IRAK2                73.46 4.60E-18     83.06   2.10E-22
Other_VPS15__SK262_p150PI3K          82.41 9.20E-21      81.4   6.30E-22
STE_Unique__zSK490b_zSK490b_GCN2b    67.87 2.20E-16     77.29   9.30E-21
Other_NKF2__SK456_PINK1              74.49 2.20E-18     76.67   1.40E-20
AGC_RSKL__SK473_AAD30182             61.96 1.30E-14     70.13   1.00E-18
Other_NRBP__SK479_NRBP1              59.65 6.50E-14     69.74   1.30E-18
Other_SCY1__SK475_SCYL2              46.34 6.60E-10     55.27   1.70E-14
Other_NRBP__SK520_NRBP2              39.56 6.00E-09     55.07   2.00E-14
Other_BUB__SK409_BUB1                22.47 8.30E-08      43.6   3.70E-11
CKI_VRK__SK389_VRK1                  32.66 1.70E-08     39.92   4.10E-10
Other_Unique__SK729_RNAseL            0.58 0.000002     37.92   1.50E-09
CKI_VRK__SK390_VRK2                  18.64 1.50E-07     37.05   2.70E-09
Other_NKF3__SK643_SGK223            -23.23 0.000094     24.78   0.000009
Other_Bud32__SK464_PRPK             -18.76 0.000047     24.51    0.00001
AGC_RSK_p70_SK732_SGK470                                23.68   0.000017
Other_Slob__SK528_Slob              -18.69   0.000047   22.78   0.000032
TK_JakB__zSK187b_zSK187b_Jak3        19.53   1.30E-07   21.26   0.000085
Other_Unique__SK652_SGK396          -18.09   0.000043   21.06   0.000098
Other_NKF3__SK649_SGK269             -7.32   0.000008   19.89   0.000211
Other_Unique__SK628_SGK196          -40.91   0.001436   18.69   0.000462
Other_Unique__SK699_SGK307                              17.48   0.001025
Other_Unique__SK460_AA396601        -86.92   1.702209   15.42   0.003948
CKI_VRK__SK535_VRK3                 -54.04   0.010814   12.55   0.025953
Other_Haspin__SK692_Haspin          -44.87   0.002639    11.7   0.045332
Other_SCY1__SK454_SCYL1             -57.63   0.018792   10.96   0.073716
Other_Unique__SK707_SGK424                               8.64   0.338251
Other_SCY1__SK468_SCYL3             -43.75 0.002221      7.57   0.683019
Other_BUB__SK053_BUBR1              -87.26 1.79224
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Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   AOK
Best score (local or global) is > e-30   AOK
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   AOK
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   AOK
Best score (local or global) is > e-30   AOK
Best score (local or global) is > e-30   AOK
Best score (local or global) is > e-30   AOK
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Uses alt K?
Best score (local or global) is > e-30   Pending sequence extension
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   AOK
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   Dead
Best score (local or global) is > e-30   AOK
Name     Accession   VAIK motif   K   HRD motif   DFG motif   Activity Prediction   HMM P score
AAK1     SK422       CALK         K   HRD         DFG         Active
ABL      SK006       VAVK         K   HRD         DFG         Active
ACK      SK009       VAVK         K   HRD         DFG         Active
ACTR2    SK010       VAVK         K   HRD         DFG         Active
ACTR2B   SK011       VAVK         K   HRD         DFG         Active
AKT1     SK018       YAMK         K   YRD         DFG         Active
AKT2     SK019       YAMK         K   YRD         DFG         Active
AKT3     SK020       YAMK         K   YRD         DFG         Active
ALK      SK024       VAVK         K   HRD         DFG         Active
ALK1     SK025       VAVK         K   HRD         DLG         Active
ALK2     SK026       VAVK         K   HRD         DLG         Active
ALK4     SK028       VAVK         K   HRD         DLG         Active
ALK7     SK405       VAVK         K   HRD         DLG         Active
AMPKa1   SK032       VAVK         K   HRD         DFG         Active
AMPKa2   SK033       VAVK         K   HRD         DFG         Active
ANKRD3   SK546       LAIK         K   HLD         DFG         Active
ARAF     SK036       VAVK         K   HRD         DFG         Active
ARG      SK037       VAVK         K   HRD         DFG         Active
ATM      SK038       QLVK         K   LGDRH       DLG         Active
ATR      SK039       MMCK         K   LGDRH       DFN         Active
AurA     SK407       LALK         K   HRD         DFG         Active
AurB     SK406       VALK         K   HRD         DFG         Active
AurC     SK043       VALK         K   HRD         DFG         Active
AXL      SK044       VAVK         K   HRD         DFG         Active
BARK1    SK045       YAMK         K   YRD         DLG         Active
BARK2    SK478       YAMK         K   YRD         DLG         Active
BIKE     SK704       CALK         K   HRD         DFG         Active
BLK      SK049       VAIK         K   HRD         DFG         Active
BMPR1A   SK027       VAVK         K   HRD         DLG         Active
BMPR1B   SK030       VAVK         K   HRD         DLG         Active
BMPR2    SK365       VAVK         K   HRD         DFG         Active
BMX      SK417       VAVK         K   HRD         DFG         Active
BRAF     SK050       VAVK         K   HRD         DFG         Active
BRK      SK051       VAIK         K   HRD         DFG         Active
BRSK1    SK598       VAIK         K   HRD         DFG         Active
BRSK2    SK015       VAIK         K   HRD         DFG         Active
BTK      SK052       VAIK         K   HRD         DFG         Active
CaMK1a   SK056       VAIK         K   HRD         DFG         Active
CaMK1b   SK662       VALK         K   HRD         DFG         Active
CaMK1d   SK572       FAVK         K   HRD         DFG         Active
CaMK1g   SK021       FALK         K   HRD         DFG         Active
CaMK2a   SK057       YAAK         K   HRD         DFG         Active
CaMK2b   SK058       YAAK         K   HRD         DFG         Active
CaMK2d   SK703       YAAK         K   HRD         DFG         Active
CaMK2g   SK060       YAAK         K   HRD         DFG         Active
CaMK4    SK061       YALK         K   HRD         DFG         Active
CaMKK1   SK697       YAMK         K   HRD         DFG         Active
CaMKK2   SK482       YAMK         K   HRD         DFG         Active
caMLCK   SK536       LAAK         K   HLD         DFG         Active
CCRK     SK483       IALK         K   HRD         DFG         Active
CDC2     SK065       VAMK         K   HRD         DFG         Active
CDC7     SK066       IALK         K   HRD         DFG         Active
CDK10    SK294       VALK         K   HRD         DFG         Active
CDK11    SK443       YALK         K   HRD         DMG         Active
CDK2            SK067     VALK   K   HRD     DFG   Active
CDK3            SK068     VALK   K   HRD     DFG   Active
CDK4            SK069     VALK   K   HRD     DFG   Active
CDK5            SK070     VALK   K   HRD     DFG   Active
CDK6            SK071     VALK   K   HRD     DFG   Active
CDK7            SK055     VAIK   K   HRD     DFG   Active
CDK8            SK072     YALK   K   HRD     DMG   Active
CDK9            SK295     VALK   K   HRD     DFG   Active
CDKL1           SK203     VAIK   K   HRD     DFG   Active
CDKL2           SK202     VAIK   K   HRD     DFG   Active
CDKL3           SK509     VAIK   K   HRD     DFG   Active
CDKL4           SK466     VAVK   K   HRD     DFG   Active
CDKL5           SK361     VAIK   K   HRD     DFG   Active
CHED            SK076     VALK   K   HRD     DFG   Active
CHK1            SK078     VAVK   K   HRD     DFG   Active
CHK2            SK079     VAIK   K   HRD     DFG   Active
CK1a            SK082     VAVK   K   HRD     DFG   Active
CK1a2           SK541     VAVK   K   HRD     DFG   Active
CK1d            SK083     VAIK   K   HRD     DFG   Active
CK1e            SK084     VAIK   K   HRD     DFG   Active
CK1g1           SK647     VAIK   K   YRD     DFG   Active
CK1g2           SK086     VAIK   K   YRD     DFG   Active
CK1g3           SK087     VAIK   K   YRD     DFG   Active
CK2a1           SK088     VVVK   K   HRD     DWG   Active
CK2a2           SK089     VVVK   K   HRD     DWG   Active
CLIK1           SK493     VAVK   K   HRD     DFG   Active
CLIK1L          SK452     VAVK   K   HRD     DFG   Active
CLK1            SK090     VAVK   K   HTD     DFG   Active
CLK2            SK091     VALK   K   HTD     DFG   Active
CLK3            SK092     VALK   K   HTD     DFG   Active
CLK4            SK484     VAVK   K   HTD     DFG   Active
COT             SK093     MACK   K   HHD     DFG   Active
CRIK            SK695     YAMK   K   HRD     DFG   Active
CRK7            SK485     VALK   K   HRD     DFG   Active
CSK             SK095     VAVK   K   HRD     DFG   Active
CTK             SK418     VAVK   K   HRD     DFG   Active
DAPK1           SK103     YAAK   K   HFD     DFG   Active
DAPK2           SK104     YAAK   K   HFD     DFG   Active
DAPK3           SK716     YAAK   K   HFD     DFG   Active
DCAMKL1         SK063     YALK   K   HRD     DFG   Active
DCAMKL2         SK527     FALK   K   HRD     DFG   Active
DCAMKL3         SK459     YAMK   K   HRD     DFG   Active
DDR1            SK400     VAVK   K   HRD     DFG   Active
DDR2            SK410     VAVK   K   HRD     DFG   Active
DLK             SK110     VAVK   K   HRD     DFG   Active
DMPK1           SK111     YAMK   K   HRD     DFG   Active
DMPK2           SK112     FAMK   K   HRD     DFG   Active
DNAPK           SK113     FLVK   K   IGDRH   DFG   Active
Domain2_MSK1    zSK242b   FAVK   K   HRD     DFG   Active
Domain2_MSK2    zSK243b   FAVK   K   HRD     DFG   Active
Domain2_Obscn   zSK601b   LAAK   K   HLD     DLG   Active
Domain2_RSK1    zSK336b   YAVK   K   HRD     DFG   Active
Domain2_RSK2    zSK337b   FAVK   K   HRD     DFG   Active
Domain2_RSK3    zSK338b   YAVK   K   HRD     DFG   Active
Domain2_RSK4    zSK518b   FAVK   K   HRD     DFG   Active
Domain2_SPEG   zSK537b   FVAK   K   HLD     DFG   Active
DRAK1          SK486     FAAK   K   HLD     DFG   Active
DRAK2          SK487     YAAK   K   HLD     DFG   Active
DYRK1A         SK234     VAIK   K   HCD     DFG   Active
DYRK1B         SK114     VAIK   K   HCD     DFG   Active
DYRK2          SK115     VALK   K   HCD     DFG   Active
DYRK3          SK488     VALK   K   HCD     DFG   Active
DYRK4          SK116     VALK   K   HCD     DFG   Active
EGFR           SK118     VAIK   K   HRD     DFG   Active
EphA1          SK121     VAIK   K   HRD     DFG   Active
EphA2          SK122     VAIK   K   HRD     DFG   Active
EphA3          SK123     VAIK   K   HRD     DFG   Active
EphA4          SK124     VAIK   K   HRD     DFG   Active
EphA5          SK125     VAIK   K   HRD     DFG   Active
EphA6          SK646     VAIK   K   HRD     DFG   Active
EphA7          SK416     VAIK   K   HRD     DFG   Active
EphA8          SK126     VAIK   K   HRD     DFG   Active
EphB1          SK127     VAIK   K   HRD     DFG   Active
EphB2          SK128     VAIK   K   HRD     DFG   Active
EphB3          SK129     VAIK   K   HRD     DFG   Active
EphB4          SK130     VAIK   K   HRD     DFG   Active
Erk1           SK134     VAIK   K   HRD     DFG   Active
Erk2           SK135     VAIK   K   HRD     DFG   Active
Erk3           SK136     VAIK   K   HRD     DFG   Active
Erk4           SK137     VAVK   K   HRD     DFG   Active
Erk5           SK408     VAIK   K   HRD     DFG   Active
Erk7           SK465     VAIK   K   HRD     DFG   Active
FAK            SK138     VAIK   K   HRD     DFG   Active
FER            SK140     VAVK   K   HRD     DFG   Active
FES            SK142     VAVK   K   HRD     DFG   Active
FGFR1          SK143     VAVK   K   HRD     DFG   Active
FGFR2          SK144     VAVK   K   HRD     DFG   Active
FGFR3          SK145     VAVK   K   HRD     DFG   Active
FGFR4          SK147     VAVK   K   HRD     DFG   Active
FGR            SK148     VAVK   K   HRD     DFG   Active
FLT1           SK150     VAVK   K   HRD     DFG   Active
FLT3           SK149     VAVK   K   HRD     DFG   Active
FLT4           SK151     VAVK   K   HRD     DFG   Active
FMS            SK094     VAVK   K   HRD     DFG   Active
FRAP           SK152     FLLK   K   LGDRH   DFG   Active
FRK            SK419     VAVK   K   HRD     DFG   Active
Fused          SK199     VALK   K   HRD     DFG   Active
FYN            SK153     VAIK   K   HRD     DFG   Active
GAK            SK155     YALK   K   HRD     DFG   Active
GCK            SK048     AAVK   K   HRD     DFG   Active
GCN2           SK490     YAVK   K   HRD     DFG   Active
GPRK4          SK156     YACK   K   YRD     DLG   Active
GPRK5          SK157     YACK   K   YRD     DLG   Active
GPRK6          SK158     YACK   K   YRD     DLG   Active
GPRK7          SK578     YACK   K   YRD     DLG   Active
GSK3A          SK162     VAIK   K   HRD     DFG   Active
GSK3B          SK163     VAIK   K   HRD     DFG   Active
HCK            SK164     VAVK   K   HRD     DFG   Active
HER2/ErbB2     SK166     VAIK   K   HRD     DFG   Active
HER4/ErbB4     SK168     VAIK   K   HRD     DFG   Active
HH498    SK494   VAIK   K   HRD   DFG   Active
HIPK1    SK169   VAIK   K   HAD   DFG   Active
HIPK2    SK495   VAIK   K   HAD   DFG   Active
HIPK3    SK314   VAIK   K   HAD   DFG   Active
HIPK4    SK582   VAIK   K   HAD   DFG   Active
HPK1     SK170   VALK   K   HRD   DFG   Active
HRI      SK496   VCMK   K   HRD   DFG   Active
HUNK     SK502   VAIK   K   HRD   DFG   Active
ICK      SK497   IAIK   K   HRD   DFG   Active
IGF1R    SK174   VAIK   K   HRD   DFG   Active
IKKa     SK175   IAIK   K   HRD   DLG   Active
IKKb     SK176   IAIK   K   HRD   DLG   Active
IKKe     SK193   VAVK   K   HRD   DFG   Active
INSR     SK178   VAVK   K   HRD   DFG   Active
IRAK1    SK179   YAVK   K   HGD   DFG   Active
IRAK4    SK257   VAVK   K   HRD   DFG   Active
IRE1     SK182   VAVK   K   HRD   DFG   Active
IRE2     SK498   VAVK   K   HRD   DFG   Active
IRR      SK183   VALK   K   HRD   DFG   Active
ITK      SK184   VAIK   K   HRD   DFG   Active
JAK1     SK185   VAVK   K   HRD   DFG   Active
JAK2     SK186   VAVK   K   HRD   DFG   Active
JAK3     SK187   VAVK   K   HRD   DFG   Active
JNK1     SK188   VAIK   K   HRD   DFG   Active
JNK2     SK189   VAVK   K   HRD   DFG   Active
JNK3     SK190   VAIK   K   HRD   DFG   Active
KDR      SK402   VAVK   K   HRD   DFG   Active
KHS1     SK191   AAVK   K   HRD   DFG   Active
KHS2     SK427   AAIK   K   HRD   DFG   Active
KIS      SK661   GALK   K   HAD   DFG   Active
KIT      SK201   VAVK   K   HRD   DFG   Active
LATS1    SK441   YATK   K   HRD   DFG   Active
LATS2    SK442   YAMK   K   HRD   DFG   Active
LCK      SK206   VAVK   K   HRD   DFG   Active
LIMK1    SK412   MVMK   K   HRD   DFG   Active
LIMK2    SK207   MVMK   K   HRD   DFG   Active
LKB1     SK208   RAVK   K   HKD   DLG   Active
LMR1     SK413   VVVK   K   HSD   DYG   Active
LMR2     SK414   VIVK   K   HSD   DYG   Active
LMR3     SK415   VVVK   K   HSD   DYG   Active
LOK      SK426   AAAK   K   HRD   DFG   Active
LRRK1    SK698   FHIK   K   FCD   DYG   Active
LRRK2    SK690   VAVK   K   YRD   DYG   Active
LTK      SK209   VAIK   K   HRD   DFG   Active
LYN      SK210   VAVK   K   HRD   DFG   Active
LZK      SK398   VAVK   K   HRD   DFG   Active
MAK      SK211   VAIK   K   HRD   DFG   Active
MAP2K1   SK217   MARK   K   HRD   DFG   Active
MAP2K2   SK218   MARK   K   HRD   DFG   Active
MAP2K3   SK238   MAVK   K   HRD   DFG   Active
MAP2K4   SK239   MAVK   K   HRD   DFG   Active
MAP2K5   SK219   LAVK   K   HRD   DFG   Active
MAP2K6   SK220   MAVK   K   HRD   DFG   Active
MAP2K7   SK230   IAVK   K   HRD   DFG   Active
MAP3K1   SK221   MAVK   K   HRD   DFG   Active
MAP3K2     SK222   LAVK   K   HRD   DFG   Active
MAP3K3     SK223   LASK   K   HRD   DFG   Active
MAP3K4     SK224   MAMK   K   HRD   DFG   Active
MAP3K5     SK225   IAIK   K   HRD   DFG   Active
MAP3K6     SK503   IAIK   K   HRD   DFG   Active
MAP3K7     SK681   IAIK   K   HRD   DFG   Active
MAP3K8     SK573   IAVK   K   HRD   DFG   Active
MAPKAPK2   SK212   FALK   K   HRD   DFG   Active
MAPKAPK3   SK213   CALK   K   HRD   DFG   Active
MAPKAPK5   SK214   FALK   K   HRD   DFG   Active
MARK1      SK215   VAVK   K   HRD   DFG   Active
MARK2      SK120   VAVK   K   HRD   DFG   Active
MARK3      SK096   VAIK   K   HRD   DFG   Active
MARK4      SK515   VAIK   K   HRD   DFG   Active
MAST1      SK345   FAMK   K   HRD   DFG   Active
MAST2      SK216   FAMK   K   HRD   DFG   Active
MAST3      SK196   FAIK   K   HRD   DFG   Active
MAST4      SK701   FAMK   K   HRD   DFG   Active
MASTL      SK455   YAVK   K   HRD   DFG   Active
MELK       SK298   VAIK   K   HRD   DFG   Active
MER        SK226   VAVK   K   HRD   DFG   Active
MET        SK227   CAVK   K   HRD   DFG   Active
MISR2      SK228   VAIK   K   HRD   DLG   Active
MLK1       SK232   VAVK   K   HRD   DFG   Active
MLK2       SK233   VAVK   K   HRD   DFG   Active
MLK3       SK356   VAVK   K   HRD   DFG   Active
MLK4       SK691   VAVK   K   HRD   DFG   Active
MNK1       SK235   YAVK   K   HRD   DFD   Active
MNK2       SK236   YAVK   K   HRD   DFD   Active
MOK        SK505   YACK   K   HRD   DFG   Active
MOS        SK237   VAIK   K   HLD   DFG   Active
MPSK1      SK506   YALK   K   HRD   DLG   Active
MRCKa      SK299   FAMK   K   HRD   DFG   Active
MRCKb      SK241   YAMK   K   HRD   DFG   Active
MSK1       SK242   YAMK   K   YRD   DFG   Active
MSK2       SK243   YAMK   K   YRD   DFG   Active
MSSK1      SK507   VALK   K   HTD   DLG   Active
MST1       SK244   VAIK   K   HRD   DFG   Active
MST2       SK245   VAIK   K   HRD   DFG   Active
MST3       SK246   VAIK   K   HRD   DFG   Active
MST4       SK431   VAIK   K   HRD   DFG   Active
MUSK       SK247   VAVK   K   HRD   DFG   Active
MYO3A      SK636   AAVK   K   HRD   DFG   Active
MYO3B      SK583   AAVK   K   HRD   DFG   Active
MYT1       SK248   YAVK   K   HLD   D--   Active
NDR1       SK249   YAMK   K   HRD   DFG   Active
NDR2       SK500   YAMK   K   HRD   DFG   Active
NEK1       SK250   YVIK   K   HRD   DFG   Active
NEK10      SK645   LAMK   K   HRD   DFG   Active
NEK11      SK574   KVLK   K   HRD   DFG   Active
NEK2       SK251   LVWK   K   HRD   DFG   Active
NEK3       SK252   FAMK   K   HRD   DFG   Active
NEK4       SK256   YVIK   K   HRD   DLG   Active
NEK5       SK558   CVIK   K   HRD   DFG   Active
NEK6       SK420   VALK   K   HRD   DLG   Active
NEK7       SK421   VALK   K   HRD   DLG   Active
NEK8       SK476   VIIK   K   HRD   DFG   Active
NEK9       SK470   VVWK   K   HRD   DYG   Active
NIK        SK253   CAVK   K   HGD   DFG   Active
NIM1       SK449   VAIK   K   HRD   DFG   Active
NLK        SK255   VALK   K   HRD   DFG   Active
NuaK1      SK195   VAIK   K   HRD   DFG   Active
NuaK2      SK472   VAIK   K   HRD   DFG   Active
Obscn      SK601   CAAK   K   HLD   DFG   Active
OSR1       SK428   VAIK   K   HRD   DFG   Active
p38a       SK264   VAVK   K   HRD   DFG   Active
p38b       SK342   VAVK   K   HRD   DFG   Active
p38d       SK344   VAIK   K   HRD   DFG   Active
p38g       SK343   VAIK   K   HRD   DFG   Active
p70S6K     SK265   FAMK   K   YRD   DFG   Active
p70S6Kb    SK266   YAMK   K   YRD   DFG   Active
PAK1       SK267   VAIK   K   HRD   DFG   Active
PAK2       SK268   VAIK   K   HRD   DFG   Active
PAK3       SK269   VAIK   K   HRD   DFG   Active
PAK4       SK430   VAVK   K   HRD   DFG   Active
PAK5       SK510   VAVK   K   HRD   DFG   Active
PAK6       SK429   VAVK   K   HRD   DFG   Active
PASK       SK499   VVVK   K   HRD   DFG   Active
PBK        SK529   WAVK   K   HGD   DVG   Active
PCTAIRE1   SK271   VALK   K   HRD   DFG   Active
PCTAIRE2   SK272   VALK   K   HRD   DFG   Active
PCTAIRE3   SK273   VALK   K   HRD   DFG   Active
PDGFRa     SK274   VAVK   K   HRD   DFG   Active
PDGFRb     SK275   VAVK   K   HRD   DFG   Active
PDK1       SK276   YAIK   K   HRD   DFG   Active
PEK        SK281   YAIK   K   HRD   DFG   Active
PFTAIRE1   SK282   VALK   K   HRD   DFG   Active
PFTAIRE2   SK462   VALK   K   HRD   DFG   Active
PHKg1      SK283   YAVK   K   HRD   DFG   Active
PHKg2      SK284   FAVK   K   HRD   DFG   Active
PIK3R4     SK262   VVVK   K   HGD   DFA   Active
PIM1       SK291   VAIK   K   HRD   DFG   Active
PIM2       SK292   VAIK   K   HRD   DFG   Active
PIM3       SK200   VAVK   K   HRD   DFG   Active
PITSLRE    SK297   VALK   K   HRD   DFG   Active
PKACa      SK300   YAMK   K   YRD   DFG   Active
PKACb      SK301   YAMK   K   YRD   DFG   Active
PKACg      SK302   YAMK   K   HRD   DFG   Active
PKCa       SK303   YAIK   K   YRD   DFG   Active
PKCb       SK304   YAVK   K   YRD   DFG   Active
PKCd       SK305   FAIK   K   YRD   DFG   Active
PKCe       SK306   YAVK   K   YRD   DFG   Active
PKCg       SK307   YAIK   K   YRD   DFG   Active
PKCh       SK270   YAVK   K   YRD   DFG   Active
PKCi       SK308   YAMK   K   YRD   DYG   Active
PKCt       SK310   FAIK   K   YRD   DFG   Active
PKCz       SK311   YAMK   K   YRD   DYG   Active
PKD1       SK309   VAIK   K   HCD   DFG   Active
PKD2       SK480   VAVK   K   HCD   DFG   Active
PKD3       SK489   VAIK   K   HCD   DFG   Active
PKG1     SK073   FAMK   K   YRD     DFG   Active
PKG2     SK075   FAMK   K   YRD     DFG   Active
PKN1     SK317   FAIK   K   YRD     DFG   Active
PKN2     SK318   FAIK   K   YRD     DFG   Active
PKN3     SK511   YAIK   K   YRD     DFG   Active
PKR      SK119   YVIK   K   HRD     DFG   Active
PLK1     SK315   FAGK   K   HRD     DFG   Active
PLK2     SK353   YAAK   K   HRD     DFG   Active
PLK3     SK316   YAVK   K   HRD     DFG   Active
PLK4     SK341   VAIK   K   HRD     DFG   Active
PRKX     SK313   FALK   K   YRD     DFG   Active
PRKY     SK320   FALK   K   YRD     DFG   Active
PRP4     SK321   VAVK   K   HAD     DFG   Active
PSKH1    SK322   YAIK   K   HRD     DFG   Active
PYK2     SK424   VAVK   K   HRD     DFG   Active
QIK      SK513   VAIK   K   HRD     DFG   Active
QSK      SK501   VAIK   K   HRD     DFG   Active
RAF1     SK324   VAVK   K   HRD     DFG   Active
RET      SK326   VAVK   K   HRD     DFG   Active
RHOK     SK327   YACK   K   YRD     DLG   Active
RIPK1    SK328   MIMK   K   HKD     DLG   Active
RIPK2    SK329   VAVK   K   HHD     DFG   Active
RIPK3    SK330   VAVK   K   HRD     DFG   Active
ROCK1    SK331   YAMK   K   HRD     DFG   Active
ROCK2    SK263   YAMK   K   HRD     DFG   Active
RON      SK332   CAIK   K   HRD     DFG   Active
ROR1     SK333   VAIK   K   HKD     DLG   Active
ROR2     SK334   VAIK   K   HKD     DLG   Active
ROS      SK335   VAVK   K   HRD     DFG   Active
RSK1     SK336   YAMK   K   YRD     DFG   Active
RSK2     SK337   YAMK   K   YRD     DFG   Active
RSK3     SK338   YAMK   K   YRD     DFG   Active
RSK4     SK518   YAMK   K   YRD     DFG   Active
RYK      SK340   AFVK   K   HKD     DNA   Active
SBK      SK650   MALK   K   HRD     DFG   Active
SGK      SK346   YAVK   K   YRD     DFG   Active
SgK069   SK581   LALK   K   YRD     DFG   Active
SgK085   SK709   LAAK   K   HLD     DFG   Active
SGK2     SK523   YAVK   K   YRD     DFG   Active
SgK288   SK658   YAIK   K   HLD     DFG   Active
SGK3     SK525   YAVK   K   YRD     DFG   Active
SgK494   SK491   FAVK   K   HRD     DFG   Active
SgK496   SK516   CALK   K   HRD     DLG   Active
SIK      SK604   VAIK   K   HRD     DFG   Active
skMLCK   SK675   LAAK   K   HLD     DFG   Active
SLK      SK348   AAAK   K   HRD     DFG   Active
SMG1     SK665   YLFK   K   LGDRH   DYN   Active
smMLCK   SK231   WAGK   K   HLD     DFG   Active
SNRK     SK625   VAVK   K   HRD     DFG   Active
SPEG     SK537   FAAK   K   HLD     DFG   Active
SRC      SK357   VAIK   K   HRD     DFG   Active
SRM      SK425   VAIK   K   HRD     DFG   Active
SRPK1    SK358   VAMK   K   HTD     DLG   Active
SRPK2    SK359   VAMK   K   HTD     DLG   Active
SSTK     SK524   VAIK   K   HRD     DFG   Active
STK33      SK463   WAIK   K   HRD   DFG   Active
STLK3      SK432   VAIK   K   HRD   DFG   Active
SYK        SK363   VAVK   K   HRD   DFG   Active
TAK1       SK364   VAIK   K   HRD   DFG   Active
TAO1       SK436   VAIK   K   HRD   DFG   Active
TAO2       SK362   VAIK   K   HRD   DFG   Active
TAO3       SK435   VAIK   K   HRD   DFG   Active
TBK1       SK531   FAIK   K   HRD   DFG   Active
TEC        SK366   VAIK   K   HRD   DFG   Active
TESK1      SK368   MVLK   K   HRD   DFG   Active
TESK2      SK532   MALK   K   HRD   DFG   Active
TGFBR1     SK029   VAVK   K   HRD   DLG   Active
TGFBR2     SK369   VAVK   K   HRD   DFG   Active
TIE1       SK370   AAIK   K   HRD   DFG   Active
TIE2       SK367   AAIK   K   HRD   DFG   Active
TLK1       SK373   AAVK   K   HYD   DFG   Active
TLK2       SK374   VAVK   K   HYD   DFG   Active
TNK1       SK375   VAVK   K   HRD   DFG   Active
Trad       SK533   VAVK   K   HLD   DLE   Active
Trio       SK376   VATK   K   HLD   DFG   Active
TRKA       SK377   VAVK   K   HRD   DFG   Active
TRKB       SK378   VAVK   K   HRD   DFG   Active
TRKC       SK379   VAVK   K   HRD   DFG   Active
TSSK1      SK705   VAIK   K   HRD   DFS   Active
TSSK2      SK474   VAVK   K   HRD   DFG   Active
TSSK3      SK471   VAIK   K   HRD   DFG   Active
TSSK4      SK534   VAVK   K   HRD   DFG   Active
TTBK1      SK526   VALK   K   HRD   DFG   Active
TTBK2      SK453   VALK   K   HRD   DFG   Active
TTK        SK383   YAIK   K   HSD   DFG   Active
TXK        SK384   VAIK   K   HRD   DFG   Active
TYK2       SK385   VAVK   K   HRD   DFG   Active
TYRO3      SK386   VAVK   K   HRD   DFG   Active
ULK1       SK387   VAVK   K   HRD   DFG   Active
ULK2       SK388   VAIK   K   HRD   DFG   Active
ULK3       SK450   VAIK   K   HLD   DFG   Active
Wee1       SK391   YAIK   K   HMD   D-E   Active
Wee1B      SK723   YAIK   K   HLD   DLG   Active
YANK1      SK624   YAMK   K   HRD   DFN   Active
YANK2      SK481   YAMK   K   HRD   DFN   Active
YANK3      SK469   YAMK   K   HRD   DFN   Active
YES        SK393   VAIK   K   HRD   DFG   Active
YSK1       SK395   VAIK   K   HRD   DFG   Active
ZAK        SK504   VAVK   K   HRD   DFG   Active
ZAP70      SK397   VAIK   K   HRD   DFG   Active
ZC1/HGK    SK437   AAIK   K   HRD   DFG   Active
ZC2/TNIK   SK438   AAIK   K   HRD   DFG   Active
ZC3/MINK   SK439   AAIK   K   HRD   DFG   Active
ZC4/NRK    SK440   TAVK   K   HRD   DFG   Active
IRAK3      SK181   YAVK   K   CGS   DFA   Active   2.00E-27
SgK110     SK592   VALK   K   HAD   DLG   Active   9.00E-27
PINK1      SK456   LAIK   K   HRD   DFG   Active   1.00E-20
BUB1       SK409   FVLK   K   HGD   DLG   Active   4.00E-11
VRK1       SK389   CVVK   K   HGD   DYG   Active   4.00E-10
RNAseL     SK729   VAVK   K   HQD   DFD   Active   1.00E-09
VRK2           SK390     CVVK   K   HGD   DYG    Active                         3.00E-09
SgK493         SK460     VALK   K   LLD   DLD    Active                         6.00E-08
BUBR1          SK053     TVIK   K   HGD   DFS    Active                            0.003
PRPK           SK464     PALE   E   HGD   DFG    Active - alternative K used    1.00E-05
Wnk1           SK508     VAWC   C   HRD   DLG    Active - alternative K used
Wnk2           SK016     VAWC   C   HRD   DLG    Active - alternative K used
Wnk3           SK641     VAWC   C   HRD   DLG    Active - alternative K used
Wnk4           SK588     VAWC   C   HRD   DLG    Active - alternative K used
CASK           SK064     FAVK   K   HRD   GFG    Inactive - missing DFG         1.00E-74
CCK4           SK411     VLVK   K   HKD   ALG    Inactive - missing DFG         3.00E-73
TTN            SK372     YMAK   K   HFD   EFG    Inactive - missing DFG         1.00E-60
SuRTK106       SK530     VILK   K   HGD    -LG   Inactive - missing DFG         1.00E-38
SgK495         SK492     ----   -   HRD   NFC    Inactive - missing DFG         6.00E-38
Trb1           SK014     LRCK   K   LGD   SLE    Inactive - missing DFG         8.00E-36
Trb2           SK160     LVCK   K   LRD   SLE    Inactive - missing DFG         7.00E-35
Trb3           SK694     YTCK   K   LRD   NLE    Inactive - missing DFG         3.00E-23
SgK269         SK649     YAVK   K   HCD   NFS    Inactive - missing DFG         8.00E-06
SgK223         SK643     YAVK   K   HRD   NFL    Inactive - missing DFG         9.00E-06
Haspin         SK692     VAIK   K   HRD   TLN    Inactive - missing DFG            0.002
PSKH2          SK602     FAIK   K   HRN   DFG    Inactive - missing HRD         1.00E-76
ILK            SK177     IVVK   K   RHA   ---    Inactive - missing HRD         5.00E-64
HSER           SK171     VILK   K   HGR   DFG    Inactive - missing HRD         8.00E-56
HER3/ErbB3     SK167     VCIK   K   HRN   DFG    Inactive - missing HRD         2.00E-50
ANPb           SK035     VAIK   K   HGS   DYG    Inactive - missing HRD         2.00E-41
CYGF           SK099     VWLK   K   HGR   DYG    Inactive - missing HRD         5.00E-36
ANPa           SK034     VAVK   K   HGN   DYG    Inactive - missing HRD         6.00E-33
VACAMKL        SK062     HTCK   K   HRN   DFH    Inactive - missing HRD         4.00E-31
Domain2_JAK1   zSK185b   VILK   K   HGN   DPG    Inactive - missing HRD         1.00E-26
CYGD           SK097     VWLK   K   HGR   DHG    Inactive - missing HRD         4.00E-26
SgK071         SK521     KQVE   E   HRN   DLS    Inactive - missing HRD         9.00E-25
Domain2_JAK2   zSK186b   VLLK   K   HGN   DPG    Inactive - missing HRD         1.00E-24
Domain2_TYK2   zSK385b   VVLK   K   HGN   DPG    Inactive - missing HRD         6.00E-23
Domain2_JAK3   zSK187b   VLLK   K   HGN   DPG    Inactive - missing HRD         1.00E-07
SgK396         SK652     ILLK   K   HGS   DFD    Inactive - missing HRD         9.00E-05
STLK6          SK434     VTIK   K   HRS   GLS    Inactive - missing HRD, DFG 4.00E-36
MLKL           SK458     KVFK   K   HGK   ELR    Inactive - missing HRD, DFG 2.00E-29
IRAK2          SK180     FVFK   K   HSN   HP-    Inactive - missing HRD, DFG 2.00E-22
SgK307         SK699     VTVK   K   HRS   NLE    Inactive - missing HRD, DFG       0.001
KSR2           SK605     VAIR   R   HKD   LFS    Inactive - missing K           5.00E-60
KSR1           SK205     VAIR   R   HKD   LFG    Inactive - missing K           7.00E-55
ULK4           SK457     VAIL   L   FCD   NFC    Inactive - missing K, DFG      2.00E-35
RSKL1          SK517     LKTE   E   CRD   YFS    Inactive - missing K, DFG      3.00E-25
RSKL2          SK473     LHLE   E   CRD   YFG    Inactive - missing K, DFG      1.00E-18
Domain2_GCN2   zSK490b   WVLQ   Q   HKV   DYS    Inactive - missing K, HRD      9.00E-21
STLK5          SK433     VTVR   R   HRS   GLR    Inactive - missing K, HRD, DFG3.00E-40
TBCK           SK664     LTPN   N   HRA   KFG    Inactive - missing K, HRD, DFG5.00E-38
EphA10         SK627     VAVH   H   HRG   GFG    Inactive - missing K, HRD, DFG2.00E-37
EphB6          SK132     VAIQ   Q   HRS   RLG    Inactive - missing K, HRD, DFG5.00E-36
NRBP1          SK479     VVWN   N   HGN   VAP    Inactive - missing K, HRD, DFG1.00E-18
NRBP2          SK520     VVWN   N   HGN   ALP    Inactive - missing K, HRD, DFG2.00E-14
SCYL2          SK475     VAVF   F   HGN   GFD    Inactive - missing K, HRD, DFG2.00E-14
Slob           SK528     LVLS   S   YGH   DLE    Inactive - missing K, HRD, DFG3.00E-05
SgK196         SK628     VALS   S   TRV   NFS    Inactive - missing K, HRD, DFG 0.0004
SCYL3          SK468     ASVF   F   HNN   GME    Inactive - missing K, HRD, DFG    0.002
VRK3           SK535     ----   -   HGN   GYG    Inactive - missing K, HRD, DFG     0.01
SCYL1    SK454   VSIF   F HNN     GLD   Inactive - missing K, HRD, DFG      0.02
SgK424   SK707   ----   - ---     ---   Inactive - missing K, HRD, DFG      0.33
TRRAP    SK380   YLVM   M LNRLN   YFR                            (atypical)
                                        Inactive - missing K, HRD, DFG
Notes




HRD motif modified in PIKKs
HRD motif modified in PIKKs
HRD motif modified in PIKKs
Second kinase domain
Second kinase domain
Second kinase domain
Second kinase domain
Second kinase domain
Second kinase domain
Second kinase domain
Second kinase domain




HRD motif modified in PIKKs
Has failed experimentally to show catalytic activity. The unusual R-K change in HRD motif is also seen in three Drosophila homologs and m




HRD motif modified in PIKKs
                                                   Catalytic activity published
Missing the canonical K residue, but has a nearby K that is conserved in several orthologs.
All Wnk family kinases lack the canonical K but contain an upstream conserved K that for Wnk1 was shown to be required for catalytic activ
All Wnk family kinases lack the canonical K but contain an upstream conserved K that for Wnk1 was shown to be required for catalytic activ
All Wnk family kinases lack the canonical K but contain an upstream conserved K that for Wnk1 was shown to be required for catalytic activ
All Wnk family kinases lack the canonical K but contain an upstream conserved K that for Wnk1 was shown to be required for catalytic activ
All family members (1 human, 1 fly, 1 worm) predicted to be inactive
Experimentally fails to show catalytic activity; homologs in fly and hydra also predicted to be inactive




All members of this family (3 human, 1 fly) are predicted to be inactive)
All members of this family (3 human, 1 fly) are predicted to be inactive)
All members of this family (3 human, 1 fly) are predicted to be inactive)


Missing C-term, but shown to have activity.

Experimentally shown to have catalytic activity, which is lost when catalytic K is mutated to E (Persad et al (2000) PNAS 97 (7) 3207-12). O
All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive
Experimentally fails to show catalytic activity
All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive
All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive
All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive

Second kinase domain; believed to have a regulatory role. All secondary domains of Jak family kinases (4 from human, 1 from fly) are predi
Aparcio and Applebury (JBC, 1996) do show kinase activity in crude extracts, maybe artefactual. All RGC group kinase domains (5 human,

Second kinase domain; believed to have a regulatory role. All secondary domains of Jak family kinases (4 from human, 1 from fly) are predi
Second kinase domain; believed to have a regulatory role. All secondary domains of Jak family kinases (4 from human, 1 from fly) are predi
Second kinase domain; believed to have a regulatory role. All secondary domains of Jak family kinases (4 from human, 1 from fly) are predi
All RGC group kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive
Both human family members are predicted to be inactive, as are 1 worm and 1 fly homolog. Another worm homolog has HRD and DFG mot




All family members (2 human, 1 fly, 1 worm) are predicted to be inactive.
All family members (2 human, 1 fly, 1 worm) are predicted to be inactive.
Second kinase domain. All GCN2 family kinases (1 human, 1 fly , 1 worm, 1 yeast) have a domain which is predicted to be inactive.
Both human family members are predicted to be inactive, as are 1 worm and 1 fly homolog. Another worm homolog has HRD and DFG mot




All family members (2 human, 1 fly, 1 worm) are predicted to be in active.
All family members (2 human, 1 fly, 1 worm) are predicted to be in active.
All members of this family (3 human, 4 fly, 2 worm, 1 yeast) are predicted to be inactive

Very divergent kinase-like domain
All members of this family (3 human, 4 fly, 2 worm, 1 yeast) are predicted to be inactive
All members of this family (3 human, 4 fly, 2 worm, 1 yeast) are predicted to be inactive
Very poor kinase domain homology, but is a clear homolog of SGK307, which has a divergent kinase domain
HRD motif modified in PIKKs. All family members (1 human, 1 fly, 1 worm, 1 yeast) are predicted to be inactive
e Drosophila homologs and may kill activity, or make it experimentally undetectable. However, a similar HKD motif is seen in several active kinases
o be required for catalytic activity (Xu et al, JBC (2000) 275:16795-801)
o be required for catalytic activity (Xu et al, JBC (2000) 275:16795-801)
o be required for catalytic activity (Xu et al, JBC (2000) 275:16795-801)
o be required for catalytic activity (Xu et al, JBC (2000) 275:16795-801)




00) PNAS 97 (7) 3207-12). Orthologs in fly and worm are also missing catalytic residues.




m human, 1 from fly) are predicted to be inactive
up kinase domains (5 human, 6 fly, 26 worm) are predicted to be inactive

m human, 1 from fly) are predicted to be inactive
m human, 1 from fly) are predicted to be inactive
m human, 1 from fly) are predicted to be inactive

molog has HRD and DFG motifs, but the predicions lacks the N-terminal end of the kinase domain




edicted to be inactive.
molog has HRD and DFG motifs, but the predicions lacks the N-terminal end of the kinase domain
is seen in several active kinases

				
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