Tylenol (Acetaminophen) by xV43uA2v

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									                                                                                                                                                    Senna
                                                                                                        USE: Short-term treatment of constipation; evacuate the colon for bowel or rectal examinations

                                                                                                        Mechanism: Active metabolite (aglycone) acts as a local irritant on the colon, stimulates
                                                                                                        Auerbach's plexus to produce peristalsis
                                    Colace (Docusate)
USE: Stool softener in patients who should avoid straining during defecation; constipation associated   Dosage Children: Tablet:
      with hard, dry stools; ceruminolytic                                                              2 to <6 years: 1/2 tablet (4.3 mg sennosides) at bedtime, not to exceed 1 tablet (8.6 mg sennosides)
Mechanism: Reduces surface tension of the oil-water interface of the stool resulting in enhanced        twice daily
incorporation of water and fat allowing for stool softening                                             6-12 years: 1 tablet (8.6 mg sennosides) at bedtime, not to exceed 2 tablets (17.2 mg sennosides)
                                                                                                        twice daily
Dosage:Infants and Children: Infants and Children: Oral: 5 mg/kg/day in 1-4 divided doses or            Children ≥12 years and Adults:
dose by age:                                                                                            Syrup: 10-15 mL (17.6-26.4 mg sennosides) at bedtime, not to exceed 15 mL (26.4 mg
<3 years: 10-40 mg/day in 1-4 divided doses                                                             sennosides) twice daily
3-6 years: 20-60 mg/day in 1-4 divided doses                                                            Tablet: 2 tablets (17.2 mg sennosides) at bedtime, not to exceed 4 tablets (34.4 mg sennosides)
6-12 years: 40-150 mg/day in 1-4 divided doses                                                          twice daily
Adolescents and Adults: Oral: 50-400 mg/day in 1-4 divided doses
Adverse Reactions                                                                                       Contraindications: Hypersensitivity to senna or any component; nausea and vomiting;
Dermatologic: Rash Gastrointestinal: Intestinal obstruction, diarrhea, abdominal cramping               undiagnosed abdominal pain, appendicitis, intestinal obstruction or perforation
Local: Throat irritation                                                                                Warnings Concentrated liquid contains sodium benzoate which may cause allergic reactions in
Contraindications: Hypersensitivity to docusate or any component; concomitant use of mineral            susceptible individuals; use products containing sodium benzoate with caution in neonates; in
oil; intestinal obstruction, acute abdominal pain, nausea, vomiting                                     vitro and animal studies have shown that benzoate displaces bilirubin from protein binding sites.
                                                                                                        Avoid prolonged use > 1wk
                                                                                                        Adverse Reactions Endocrine & metabolic: Electrolyte and fluid imbalance
                                                                                                        Gastrointestinal: Nausea, vomiting, diarrhea, abdominal cramps, perianal irritation, discoloration
                                                                                                        of feces
                                                                                                        Genitourinary: Discoloration of urine

                                                                                                        NOTE: Docusate (Colace) may increase absorption of Senna




                                           Lactulose
USE: Adjunct in the prevention and treatment of portal-systemic encephalopathy (PSE);
treatment of chronic constipation
Mechanism: The bacterial degradation of lactulose resulting in an acidic pH inhibits the
diffusion of NH3 into the blood by causing the conversion of NH3 to NH4+; also enhances the
diffusion of NH3 from the blood into the gut where conversion to NH4+ occurs; produces an
osmotic effect in the colon with resultant distention promoting peristalsis and elimination of NH 4+
from the body
Precautions Use with caution in patients with diabetes mellitus; do not use with other laxatives
especially when initiating PSE treatment as increased loose stools may falsely suggest adequate
lactulose dosage
Adverse Reactions : Not for use with varicella, cautions for drug seeking behaviors SEE LEXI-
Peds
Contraindications: Hypersensitivity to lactulose or any component; galactosemia or patients
requiring low galactose diet
Peds Dosage: Constipation: Oral:
Children: 7.5 mL/day (5 g/day) after breakfast
Adults: 15-30 mL/day (10-20 g/day); increase to a maximum of 60 mL/day (40 g/day) if needed

								
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