Tablet Coating.ppt by zhaonedx

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									           Tablet Coating
                Why    coat tablets?




                Types   of coatings
                    sugar coating
                    film coating
                    press coating (compression coating)



CHEE 440                                                   1
           Sugar Coating
              stages involved
                  sealing of tablet core

                  subcoating

                  smoothing

                  colouring

                  polishing

                  printing



CHEE 440                                    2
           Film Coating
              involves spraying a solution of polymer + pigments +
               plasticizers onto a rotated, mixed tablet bed
              forms a thin, uniform film on tablet surface

              materials
                  polymers
                  solvents
                  plasticizers
                  colorants




CHEE 440                                                              3
           Film Formation

                            latex particles dispersed
                            in aqueous phase




                            formation of thin film with
                            water evaporation through film



                             continuous film




CHEE 440                                                4
           Coating Process
              coating pans




CHEE 440                      5
           Coating Process
              fluid beds




CHEE 440                     6
           Important Processing Parameters
            inlet and bed temperatures
            relative humidity
            atomization air pressure
            liquid spray rate
            droplet size
            drying time




CHEE 440                                     7
           Coating Problems
                 picking/chipping


                 roughness


                 sticking


                 film   cracking/peeling




CHEE 440                                    8
           Normal Coating
                                        Average
                         Reconstitution
           Description                  weight     Application examples
                         level
                                        gain
           HPMC based                              Amoxycillin, Azithromycin, Atenolol,
           Aqueous       11% to 15%        2.5 %   Amlodipine, Amitriptyline, Ampicilin
           system                                  Ciprofloxacin, Cephadroxil ,
                                                   Cimitidine, Calcium Tablets, Citrizine
           HPMC based                              , Chloroquine Phosphate,
           Organic                                 Clarithromycin, Erythromycin,
                         5%                2.5%
           solvent                                 Ferrous Fumarate, Famotidine,
           system                                  Ferrous Sulphate, Ibuprofen,
                                                   Indapamine, Losartan Potassium,
           HPMC based                              Levamisole, Methyl-Dopa,
           Aqueous/      Aqueous 11%
                                                   Metronidazole+Tinidazole,
           Organic       Organic Solvent           Metronidazole, Methyl Coblamine,
           Solvent/      5%                2.5%    Mefenamic Acid, Metoprolol Tartrate,
           Hydro                                   Norfloxacin, Nifidipine,
                         Hydro Alcoholic
           Alcoholic                               Norfloxacin+Tinidazole, Ofloxacin,
                         9%
           system                                  Paracetamol, Quinine Sulphate,
                                                   Roxythromycin, Secnidazole,
           PVA based                               Sildenafil Citrate, Trimetazidine,
           Aqueous       20% to 25%        2.5%    Tinidazole, Tinidazole-Doxycycline,
           system                                  Tinidazole + Tetracycline, Verapamil



CHEE 440                                                                                    9
           Enteric-coated
            coating resists dissolution or disruption in stomach
             but not in intestines
            used for drugs that are unstable, irritating to
             stomach




CHEE 440                                                            10
           Enteric Coating
                                          Average
                           Reconstitution
     Description                          weight    Application ** examples
                           level
                                          gain
     Organic Enteric
     Coating system,                                Aspirin, Bisacodyl
                           5%                8%
     Cellulose Acetate
     Phthalate based
                                                    Diclofenac Sodium
     Aqueous coating
     system & Organic
     enteric coating                                Doxylamine Succinate
                           Organic: 5%
     system. Hydroxy                         8%
                           Aqueous: 10%
     Propyl Methyl
     Cellulose Phthalate                            Garlic Tablets, Omeprazol,
     based system.                                  Pentaprazole,

                           Aqueous 20%
     Methacrylic acid                               Pentoxyfyline, Rabeprazol ,
                           Hydro Alcoholic
     copolymer type "C"
                           10%               9%
     USP/NF based
     system                Organic System           Serrosipeptadise
                           10%


CHEE 440                                                                          11
           Press Coating
              use of compression to form coat around a pre-
               formed core




              used mainly to separate chemically incompatible
               materials
                  also dual release patterns possible




CHEE 440                                                         12

								
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