Drying (PowerPoint download) by yurtgc548

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									                               Drying
      *- Drying is commonly the last stage in a manufacture process.
  *- Drying is the final removal of water from material (usually by heat)
 .Non –thermal drying *                   1- As Squeezing wetted sponge
         2*-Adsorption by desiccant (desiccation)    3*- Extraction.

                          Purposes of drying

 •- In pharmaceutical technology, drying is carried out for one or more of
                         the following reasons:

    1-To avoid or eliminate moisture which may lead to corrosion and
                  decrease the product or drug stability.
2-To improve or keep the good properties of a material, e.g. flowability,
                              compressibility.
   3-To reduce the cost of transportation of large volume materials (
                                  liquids)
       4-To make the material easy or more suitable for handling.
                             5- Preservative.
       6- The final step in: Evaporation- Filtration- Crystallization.
       Difference between drying and evaporation

• 1- In drying processes, the main operation usually carried out on
  solid materials, e.g. powders, or products.

• 2- Drying in most of the cases means the removal of relatively
  small amounts of water from solids .Evaporation include the
  removal of large amounts of water from solutions.

• 3- In most cases, drying involves the removal of water at
  temperatures below its boiling point, whereas evaporation means
  the removal of water by boiling a solution.

• 4- In drying , water is usually removed by circulating air over the
  material in order to carry away the water vapour , while in
  evaporation , water is removed from the material as pure water
  vapour mixed with other gases.
                    Classification of dryers

• Based on solid handling (static bed dryer-moving bed-fluidized
  bed).
• Based on heat transfer (direct dryers-Indirect-IR or radiant heat).

Dryers for Dilute Solutions and Suspensions


• The objective of these dryers is to spread the liquid to a large
  surface area for heat and mass transfer for collecting the dry
  solid.

• Two main types are used:
• The first, spreading the liquid to a thin film.
• The second, dispersing the liquid to a spray of small droplets.
                     Drum Dryer (Film Drying)

• It consists of a drum of about 0, 75-1.5 m in diameter and 2-4 m in
    length, heated internally, usually by steam, and rotated on its
    longitudinal axis.

• Operation: The liquid is applied to the surface and spread to a film,
  this may be done in various ways, but the simplest method is that
  shown in the diagram, where the drum dips into a feed pan. Drying
  rate is controlled by using a suitable speed of rotation and the
  drum temperature. The product is scraped from the surface of the
  drum by means of a doctor knife.



•              Fig. Drum dryer
                       Advantages of the drum dryer

     1- The method gives rapid drying, the thin film spread over a large area
        resulting in rapid heat and mass transfer.
     2- The equipment is compact, occupying much less space than other
        dryers.

     3- Heating time is short, being only a few seconds.
     4- The drum can be enclosed in a vacuum jacket, enabling the
        temperature of drying to be reduced.
     5- The product is obtained in flake form, which is convenient for many
        purposes.

•   The only disadvantage : is that operating conditions are critical and it is
    necessary to introduce careful control on feed rate, film thickness, speed of
    drum rotation and drum temperature.

•   Uses: 1- It can handle a variety of materials, either as solutions or as
    suspensions e.g. starch products, ferrous salts and suspensions of kaolin.
                             Spray Dryer

  The spray dryer provides a large surface area for heat and mass
  transfer by atomizing the liquid to small droplets. These are sprayed
  into a stream of hot air, so that each droplet dries to a solid particle.
• The drying chamber resembles the cyclone ensuring good
  circulation of air, to facilitate heat and mass transfer, and that dried
  particles are separated by the centrifugal action.....
• The character of the particles is controlled by the droplet form;
  hence the type of atomizer is important.
• Rotary atomizer is preferable than jet which is easily blocked. Liquid
  is fed to the disc of the atomizer which is rotated at high speed (up
  to 20,000 rpm), a film is formed and spread as uniform spray. In
  addition, the rotary atomizer is effective with suspensions. It can be
  operated efficiently at various feed rates.




•            Fig. Rotary atomizer
            Characterization of spray dried products ;


     The products are uniform in appearance and have characteristic
    shape, in the form of hollow spheres with a small hole. This arises
    from the drying process, since the droplet enters the hot air stream,
    and dries on the outside to form an outer crust with liquid still in the
    center. This liquid then vaporizes, the vapour escaping by blowing a
    hole in the sphere.

•    This method of drying allows a dry product to retain some
    properties of feed , e.g., a drop from an emulsion dries with
    continuous phase on the outside. When reconstituted, the emulsion
    is easily re- formed.
             Advantages of the spray drying process

• 1-The droplets are small, giving a large surface area for heat
  transfer, so that evaporation is very rapid. The actual drying
  time of a droplet is only a fraction of a second, and the overall
  time in the dryer is only a few seconds.

• 2- Because evaporation is very rapid, the droplets do not attain
  a high temperature, most of the heat being used as latent heat of
  vaporization.

• 3- The characteristic particle form gives the product a high bulk
  density and, in turn, ready solubility.

• 4- The powder will have a uniform and controllable particle size.
• 5- The product is free-flowing, with almost spherical particles, and is
  especially convenient for tablet manufacture.

• 6- Labour costs are low, the process yielding a dry, free-flowing
  powder from a dilute solution, in a single operation with no handling.

• 7- It is possible to operate spray driers aseptically using heated
  filtered air to dry products such as serum hydrolysate.

• 8- Some spray driers operate in a closed-circuit mode with an
  inert gas to minimize oxidation of the product. Volatile solvents
  can be recovered from such systems.
                             Disadvantages & Uses

•   The equipment is very bulky, connected to accessories, fans, heaters,)
•   That is make it expensive.
•   Uses:
•   1- Drying of any substance in solution or in suspension form.
•   2- It is most useful for drying of thermolabile materials e.g. antibiotics.
•   3- Suitable for large quantities solution.
•   4- Suitable for both soluble and insoluble substances e.g. citric acid,
    gelatin, starch.
•   5- It can produce spherical particles in the respiratory range e.g. dry
    powder inhalers.
•   6- Drying of milk, soap and detergents which is pharmaceutically related
    compounds.




•   .........................Fig. Formation of product in spray drying, Aulton, p 390
                             Freeze Drying


• Freeze drying is a process used to dry extremely heat – sensitive
  materials. It allows the drying , without excessive damage, of
  proteins, blood products and even microorganisms, which retain a
  small but significant viability.

•       In this process the initial liquid solution or suspension is frozen,
    the pressure above the frozen state is reduced and the water
    removed by sublimation.

• Thus a liquid –to-vapour transition takes place, but here three states
  of matter involved: liquid to solid, then solid to vapour
                      The phase diagram for water

•         The phase diagram for the water
 system is shown in the corresponding figure..
...........
• The diagram consists of three separate
 areas representing the phases of water,
 solid, liquid, and vapour . The point O
 is the only point where all the three
phases can coexist, and is known as the
 triple point .

On heating at constant atmospheric
pressure ice will melt when the temperature
rises to 0 C . At this constant temperature and
pressure it will then change to water. Continued
heating will raise the temperature of the water to
100 C where, if heat addition is continued, the liquid
water will be converted into water vapour at 100 C.
•    If , however, solid ice is maintained at a pressure below the triple
    point then on heating the ice will sublime and pass directly to water
    vapour without passing through the liquid phase.

•   This sublimation, and therefore drying, can occur at a temperature
    below 0 C.

• This will only happen if the pressure is prevented from rising above
  the triple point pressure .

•    It may be thought that as the process takes place at a low
    temperature the heat required to sublime the ice will be small.
Freeze Dryer
            Limitations of the freeze drying process.
•   The freeze drying of products such as blood plasma, although simple in
    theory, presents a number of practical problems:-

•   1-The depression of the freezing point caused by the presence of dissolved
    solutes means that the solution must be cooled below the normal freezing
    temperature for pure water (-10-30).

•   2-Sublimation can only occur at the frozen surface and is slow process (1mm
    thickness of ice per hour). So, the surface area must therefore be increased and

•   3-the liquid thickness prior to freezing be reduced in order to reduce the thickness
    of ice to be sublimated.

•   4-At low pressure large volumes of water vapour are produced which must be
    removed to prevent the pressure rising above the triple point pressure.

•   5-The dry material often needs to be sterile, and it must also be prevented from
    regaining moisture prior to the final packaging.
            Stages of the freeze drying process
• 1- Freezing stage:
• The liquid material is frozen before the application of vacuum to
  avoid frothing, and several methods are used to produce a large
  frozen surface.
• a- Shell freezing : This is employed for large volumes such as blood
  products. The bottles are rotated slowly and almost horizontally
  in a refrigerated bath. The liquid freezes in a thin shell around the
  inner surface of the bottle.
• Freezing is slow and large ice crystals form, which is a drawback
  of this method.
• In vertical spin freezing the bottles are spun individually in a
  vertical position , centrifuged and cooled by a blast of cold air. The
  solution super cools and freezes rapidly, with the formation of small
  ice crystals.
• b- Centrifugal evaporative freezing: The solution is spun in small
  containers within a centrifuge. This prevents the foaming when a
  vacuum is applied. The vacuum causes boiling at room temperature.
  About 20% of the water is removed prior to freeze drying and there
  is no need for refrigeration. Ampoules are usually frozen in this way
•   2 - Vacuum application stage: The containers and the frozen material
    must be connected to a vacuum source sufficient to drop the pressure
    below the triple point and remove the larger volumes of low – pressure
    vapour formed during drying.

•   3 - Sublimation stage:
•   Heat of sublimation must be supplied. Under these conditions the ice slowly
    sublimes, leaving a porous solid which still contains about 0.5% moisture
    after primary drying .
•   Primary drying: It can reduce the moisture content of a freeze-dried solid
    to around 0.5%. Further reduction can be affected by secondary drying .
•   Heat transfer: Insufficient heat input prolongs the process, which is already
    slow, and excess heat will cause melting.
•   Vapour removal: The vapour formed must be continually removed to avoid
    a pressure rise that would stop sublimation.
•   Rate of drying: The rate of drying in freeze drying is very slow, the ice
    being removed at a rate of about only 1mm depth per hour.
                    Advantages of freeze drying

•   4- Secondary drying:
•   The removal of residual moisture at the end of primary drying is performed by
    raising the temperature of the solid to as high as 50 or 60 C .

•   5- Packaging:
•      Attention must be paid to packaging freeze-dried products to ensure protection
    from moisture. Containers should be closed without contacting the atmosphere.

•   Advantages of freeze drying

•   1- Drying takes place at very low temperatures, so the chemical decomposition,
    particularly hydrolysis is minimized.
•   2- The solution is frozen occupying the same volume as the original solution, thus ,
    the product is light and porous.
•   3- The porous form of the product gives ready solubility.

•   4- There is no concentration of solution prior to drying. Hence, salts do not
    concentrate and denature proteins, as occurs with other drying methods.
•   5- As the process takes place under high vacuum there is little contact with air,
    and oxidation is minimized.
          Disadvantages & Uses of freeze drying


• Disadvantages:

• -There are two main disadvantages:
• 1-The porosity, ready solubility and complete dryness yield a very
  hygroscopic product. Unless products are dried in their final
  container and sealed in situ, packing require special conditions.
• 2-The process is very slow and uses complicated plant, which is
  very expensive .It is not a general method of drying but limited to
  certain types of valuable products.

• Uses of freeze drying
• The method is used for products that can not be dried by any other
  heat method. These include biological products, e.g. antibiotics,
  blood products, vaccines, enzyme preparations and microbiological
  cultures.
                   Dryers for Solid Materials

• Moisture content of wet solids
• The moisture content of a wet solid is expressed as kilograms of
  moisture associated with 1 kg of the moisture – free solid. Thus a
  moisture content of 0.4 means that 0.4 kg of removable water is
  present per kg of the solid. It is sometimes calculated as percentage
  moisture content.
• Total moisture content: This is the total amount of liquid associated
  with a wet solid. The easily removable water is known as the free
  moisture content, and the moisture which is more difficult to
  remove is the equilibrium moisture content. The easily removable
  water is known as unbound water.

• Unbound water: This water exists as a liquid and exerts its fully
  vapour pressure, it can be removed readily by evaporation. During a
  drying process this water is easily lost but the resulting solid is not
  completely free from water molecules.
• Equilibrium moisture content:

• The moisture content present in a solid under steady-state ambient
  conditions is termed the eq. moisture content. Its value changes with
  temperature, humidity and the nature of the solid.

• Bound water :
• Part of the moisture present in a wet solid may be adsorbed on
  surfaces of the solid or be adsorbed within its structure to such an
  extent to prevent it from developing its full vapour pressure and from
  being easily removed by evaporation. Such moisture is described as
  “bound” and is more difficult to remove than unbound water.
                 Relative humidity (RH) of air
• Air at a given temperature is capable of taking up water vapour until
  it is saturated (at 100% RH ). If the temperature is raised then the
  air will be able to take up more moisture and the relative humidity
  falls.
• The RH of air is dependent not only on the amount of moisture in the
  air , but also on its temperature, as the amount of water required to
  saturate air is itself dependent on temperature.

• It should be noted that in convective drying, where warm air is
  passed over the surface of a wet solid, the relative humidity may rise
  during the drying process as a result of two separate factors:-

• 1- Uptake of evaporated water vapour from the wet solid,
• 2- The cooling of the supply air as it transfers heat to the wet solid
  (evaporative cooling).
• If the cooling is excessive the temperature of the air may fall to a
  value known as the dew point, when liquid water will condense and
  be deposited.
    Relationship between equilibrium moisture content
               (EMC) and relative humidity

•   The EMC of a solid exposed to moist air varies with the relative
  humidity (Fig 26.2, Aulton p.382). Ordinary atmospheric
  conditions are of the order of 20 C and 70-75 RH
• , so that if exposed to atmosphere a material such as kaolin will
  contain about 1% moisture, whereas a starch –based product may
  have as much as 30% or more. Materials exposed to humid
  conditions will regain moisture, and so there is no advantage in
  drying to moisture content lower than that which the material will
  have under the conditions of use
                    Loss of water from wet solids

•  Unbound water is easily lost by evaporation until the equilibrium
  moisture content of the solid is reached (Fig 26,3, Aul) , Once the
  solid reaches its EMC , extending the time of drying will not change
  the moisture content as an equilibrium situation has been reached.
  The only way to reduce the moisture content is to reduce the RH of
  the ambient air. This can be done mechanically with an air-
  conditioning system.
• On small scale, desiccators are used.




• ...... Fig 26.2   ...........Fig.26.3...............(Aul
      Different techniques of drying of solids ( Drying
                         methods)

•    The following points should be considered before the selection of
    the suitable drying method:

• 1- Heat sensitivity the material being dried.
• 2- Physical characteristics of the material.

• 3- Nature of the liquid to be removed.
• 4- The scale of the operation.

• 5- Available sources of heat (steam, electrical).
    The general principles for efficient drying can be
                summarized as follows


• 1- Large surface area for heat transfer.

• 2- Efficient heat transfer per unit area (to supply sufficient latent heat
  of vaporization or heat of sublimation in case of freeze-drying)

• 3- Efficient mass transfer of evaporated water through any
  surrounding boundary layers, i.e. sufficient turbulence to minimize
  boundary layer thickness.

• 4- Efficient vapour removal , i.e. low relative humidity air at adequate
  velocity.

• It is convenient to categorize pharmaceutical driers according to the
  heat transfer method they use, i.e. convective, conductive or radiant.
                      Convective Drying of Wet Solids
•   I-Fixed (or static) bed convective drying e.g. tray drier

•       Tray drier:




•      In Fig.26.4. tray drier. Air flows in direction of the arrows over each shelf
    in turn. The wet material is spread on shallow trays resting on the shelves.
    Electrical elements or steam-heated pipes are positioned as shown, so that
    the air is periodically reheated after it has cooled by passage over the wet
    material on one shelf before it passes on the next.

•   .Fig.26..4................Directed- circulation tray drier.,Aul,p.383.
              Rate of drying in a bed of powder:

• The rate at which drying occurs has been found to show certain
    phases (fig.26.5, Aul) in which the change in moisture content is
    plotted against time. From A to B
    the relationship is linear, which is
   known as the constant-rate period,
  whereas from B to C the rate of loss
  of moisture decreases and is known
  as the falling-rate period. The end
  of the constant rate period, B,is referred
 to as the critical moisture content.
- The first falling- rate period has
 a linear relationship, that is , the
 decrease in drying rate is uniform,
whereas in the second falling-rate
period there is a continuous decrease
 in the rate of drying until the EMC is
reached.

Each of these periods will
be considered in more details.
Constant-rate period: It is found that the evaporation rate from the
    drying bed is similar to that of
   the solvent alone from a free
 liquid surface under the same
conditions, indicating that the
 evaporation takes place from
the wet surface of the solid, and
 that the surface remains wet in
this period as a result of the liquid
 being replaced from below as
fast as it is vaporized
    Controlling factors in this
 period are the rate at which
 heat can be transferred and
 the rate of removal of the vapour.
• First falling-rate period: As moisture is removed from the surface, a
    point will be reached when the rate of vaporization is insufficient
    to saturate the air in contact
 with the surface. Under these
conditions, the rate of drying
will be limited by the rate of
 capillary transfer of the liquid
to the surface of the wet bed,
 and this becomes increasingly
 difficult as the bed dries, the
 solvent level decreases and
 thus has further to travel to
the point of evaporation.
Consequently, the rate of drying
decreases continuously.
• Second falling-rate period: Any moisture that remains within the
    drying bed at the end of the first falling –rate period is unable to
    move, so that drying cannot
 take place on the surface. i.e.
 the drying rate depends on the
 movement of the vapour through
 the pores of the bed to the surface,
 in general by molecular diffusion
• Minimal atmospheric humidity above the solid , in addition to the
  thermal conductivity of the solid decreases as it becomes dry, if the
  solid is thermostable it is safe to allow temperature gradients to
  increase to maintain the rate of heat transfer, but if the material is
  thermolabile the heating must be decreased.
•      In the operation of a tray drier it is usual to remove the dry
  material on the trays near the air inlet and replace them with the
  trays with partially dry material from further away.




• .Fig 26.5 Drying curve.., Critical moisture content (CMC),
  Equilibrium moisture content ( EMC)...Ault, P.384.
                 II- Dynamic convective driers
                   Example, fluidized – bed drier.

• Good contact between the warm drying air and wet particles is found
  in the fluidized – bed drier.
• Principles of fluidization. The particulate matter is contained in a
  vessel, of which is perforated, enabling a fluid to pass through the
  bed of solids from below.
•      If the air velocity through the bed is increased gradually and the
  pressure drop through the bed is measured, a graph of the operation
  shows several distinct regions, as indicated in the fig.
• Fig.26.6..Effect of air velocity on pressure drop through a
  fluidized bed........
-   At first, when the air velocity is low, (point A) , flow takes place
    between the particles without casing disturbance, but as the velocity is
    increased e point (B), is reached (gravity = force of fluidization on that
    particle). Rearrangement of the particles occurs to offer least resistance
    (C), and they are suspended in the air and can move.
• At point (D), pressure drop through
 the bed decreases slightly because of
 the greater porosity. Further increase
in the air velocity causes the particles to
separate and move freely and the bed is
 fully fluidized.
 Any additional increase in
velocity separates the particles further,
 that is, the expands without appreciable
change in the pressure drop, until (E),
when the air velocity is sufficient to transport
 the particles to the top of the bed.
• In the region D---E fluidization is irregular , much of the air flowing
    through in bubbles, the term boiling bed being commonly used to
    describe it .
• The important fact is that to produces
 conditions of great turbulence,
 the particles mixing with good
contact between them and the air.
 Hence if hot air is used the
 turbulent conditions lead to
 high heat and mass transfer
 rates, the fluidized – bed technique
therefore offers a mean of rapid drying.
             Advantages of fluidized-bed drying

•   1- Efficient heat and mass transfer give high drying rates, so that
    drying times are shorter than with static-bed convection driers.
    Economic, heat challenge to thermolabile materials is minimized.
•   2-The fluidized state of the bed ensures that drying occurs from
    the surface of all the individual particles and not just from the
    surface of the bed. Hence, most of the drying will be at constant
    rate and the falling –rate period is very short.
•   3-The temperature of a fluidized bed is uniform and can be
    controlled precisely.
•   3-The turbulence in a fluidized bed causes some attrition to the
    surface of the granule. This produces a more spherical free-
    flowing product.
•   5-The free movement of individual particles eliminates the risk of
    soluble materials migrating, as may occur in static beds.
        Disadvantages of fluidized-bed drying

•   1-The turbulence of the fluidized state may cause excessive
    attrition of some materials, with damage to some granules and the
    production of too much dust.

•   2- Fine particles may become entrained in the fluidizing air and
    must be collected by bag filters, leading to segregation and loss of
    fines.

•   3-The vigorous movement of particles in hot dry air can lead to
    the generation of static electricity charges. The danger is
    increased if the fluidized material contains a volatile solvent such
    as isopropanol. Adequate electrical earthing is essential.
               Conductive Drying of Wet Solids

• Mechanism of heat transfer:
• 1- Conduction:
• The transfer of heat from one part of a body to another, without
  appreciable displacement of the particle is referred as conduction.
  This mode of heat transfer is called molecular heat transfer,
  because it involves the transfer of kinetic energy from one molecule
  to the one adjacent to it, e.g. conduction of heat along the length of
  a metal rod when one end is heated.
• 2- Convection:
• The transfer of heat from one point to another in a body of fluid,
  such as a liquid or a gas, by a mixing process, is referred to as
  convection heat transfer .In most cases convection involves the
  transfer of heat from a solid surface to the bulk of the fluid, the
  change in heat induce a change in the density of the liquid e.g.
  the conventional currents observed when water is heated in a glass
  beaker.
• 3- Radiation:
• The transfer of heat by radiant energy in the form of
  electromagnetic waves, which travel in straight lines at the speed
  of light, is referred to as radiation heat transfer. As a body is
  heated, it emits radiant energy, e.g. sun and infrared heat lamps.
  When this radiation strikes another body, portions may be reflected
                            Vacuum oven

•    This equipment is a good example of conduction drier. The vacuum
    oven consists of a jacketed vessel to withstand vacuum within the
    oven. There are supports for the shelves giving a larger area for
    conduction heat transfer. The oven can be closed by a door. The
    oven is connected through a condenser and liquid receiver to a
    vacuum pump.
     Operating pressure can be as low as 0.03-0.03 bar, at which
    pressures water boils at 25-35 C.

• Advantages of vacuum oven:
• Drying takes place at a low
  temperature.
• There is little air present, so,
  there is minimum risk of oxidation.
               Radiation Drying of Wet Solids

• Radiant heat transmission:

• Heat transmission by radiation differs from heat transfer by
  conduction or convection in that no transfer medium (solid, liquid
  or gaseous) need be present. Heat energy in the form of radiation
  can cross empty space or travel through the atmosphere virtually
  without loss. If it falls on a body capable of absorbing it then it
  appears as heat, although a proportion may be reflected or
  transmitted.

• Use of infrared radiation :

• Infrared heating has been used to dry wet granules, but it suffers
  from the disadvantage that it is absorbed very quickly and does
  not penetrate far into the wet mass.
• The surface layers dry quickly and the absorption of further energy
  then raises the temperature of the dry material to a high value. For
  this reason infrared radiation is now seldom used as a heat source
  in pharmaceutical manufacture.
               The use of microwave radiation

• Although energy in the IR region is more easily generated there are
  other, longer, wavelengths that can generate heat when the
  radiation is absorbed by a wet solid. Microwave radiation in the
  wavelength range 10 mm to 1m penetrates much better than IR
  radiation. Microwave driers are used now in pharmaceutical
  industry.

• Generation and action of microwaves

• Microwaves are produced by an electronic device known as a
  magnetron. Microwave energy can be reflected down through a
  window into a drying chamber.
•     The penetration of microwaves into the wet product is so good
  that heat is generated uniformly within the solid.
• When microwaves fall on substances of small polar molecules
  such as water, the electrons in the molecule try to resonate in
  sympathy with the radiation and the resulting molecular “Friction”
  results in the generation of heat. Dry solids do not resonate as
  well as water, so further heating may be avoided once the water is
  removed.

•        The absorption of the microwave energy is far greater for
    small polar molecules than for larger and less polar molecules
    (methanol-ethanol-water are larger than starch and lactose which
    is larger and less polar molecules). This is indicated by the value
    of the loss factors of each substance. The loss factor is a measure
    of the ratio of the microwave energy absorbed by individual
    molecules, the higher the number the greater the absorption of
    microwave energy.
             A microwave drier for granulates

• Figure 26.9 (Aul, p.388) is a sketch of microwave drier. It is
  designed to operate under a slight vacuum. This in itself is not
  essential for the use of microwaves, but the air flow allows the
  continuous removal of evaporated solvent. The radiation is
  generated by multiple magnetrons. The radiation passes through a
  window into the drying chamber, where it is absorbed by the
  liquid in the wet granules contained on a tray. The heat generated
  in the mass drives off the moisture and the evolved vapour is
  drawn away in the air flow as it is formed. When drying is nearly
  complete the radiation field intensity will rise, as the dry solids do
  not absorb as readily as water. This rise is detected and the
  magnetrons are progressively turned off automatically, to give an
  accurate control of the final moisture content and minimize the
  danger of over-heating.



                       Fig.26.9 Microwave drier
               Advantages of microwave drying:
•   1- It provides rapid drying at low temperature.

•   2- The thermal efficiency is high, as the drier casing and the air
    remain cool. Most of the microwave energy is absorbed by the
    liquid in the wet material.

•   3- The bed is stationary, avoiding the problems of dust and
    attrition.
•   4- Solute migration is reduced as there is uniform heating of the
    wet mass.

•   5- Equipment is highly efficient; all the requirements of product
    and operator safety follow the GMP considerations.

•   6- Granulation end-point can be detected by measuring the
    residual microwave energy, ( it is rises sharply when there is little
    solvent left to evaporate).
           Disadvantages of microwave drying:


•   1- The batch size of microwave driers is smaller than
    those available for fluidized-bed driers.

•   2- Care must be taken to shield operators from the
    microwave radiation, which can cause damage to
    organs such as the eyes and testes. This is ensured
    by “Failsafe” devices preventing the generation of
    microwaves until the drying chamber is sealed.

								
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