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Material Safety Data Sheet
Conforms to 93/112/EC and ISO 11014-1

Responsible Name Pierce Administration

Section 1. Chemical Product and Company Identification
Product name

DirectDetect™ Spike Biacridine Trigger Solution
Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 USA 815.968.0747 or 1.800.874.3723

Product No. 0034132 In Europe: Manufacturer Perbio Science Industriezone III Industrielaan 27 9320 Erembodegem-Aalst Belgium Tel:+32 53 83 44 04 Fax:+32 53 83 76 38 Print Date In Case of Emergency CALL CHEMTREC: 800.424.9300 Validation Date OUTSIDE US: MSDS# 202.483.7616 Supplier In USA: Pierce P.O. Box 117 Rockford, IL 61105 USA 815.968.0747 or 1.800.874.3723

11/13/2002

11/4/2002
3306

Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.

Section 2. Composition, Information on Ingredients
Substance/Preparation Ingredient Name 1) Acetic Acid, pHix Buffer Grade 2) Isopropyl Alcohol

:

Preparation CAS No. 64-19-7 67-63-0 % 1-3 0.1-1 EC Number 200-580-7 200-661-7 Symbol C F, Xi R-Phrases R10, R21, R35 R11, R36/37

Section 3. Hazards Identification
United States Review the most current and approved institutional guideline, protocol, standard operating procedure(s) and MSDS(s) for the proper handling of institutional materials/equipment associated with the use of this product. Emergency Overview DANGER! BIRTH DEFECT HAZARD CONTAINS MATERIAL WHICH CAN CAUSE BIRTH DEFECT. HIGHLY FLAMMABLE LIQUID AND VAPOR. VAPOR MAY CAUSE FLASH FIRE. CONTAINS MATERIAL WHICH CAUSES DAMAGE TO THE FOLLOWING ORGANS: KIDNEYS, NERVOUS SYSTEM, REPRODUCTIVE SYSTEM, CARDIOVASCULAR SYSTEM, RESPIRATORY TRACT, SKIN, EYES, , CENTRAL NERVOUS SYSTEM, EYE, LENS OR CORNEA. MAY BE HARMFUL IF ABSORBED THROUGH SKIN. Keep away from heat, sparks and flame. Avoid prolonged contact with eyes, skin, and clothing. Keep container closed. Use only with adequate ventilation. Avoid exposure during pregnancy. Wash thoroughly after handling. Routes of Entry Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion. Potential Acute Health Effects Slightly hazardous in case of ingestion. Non-permeator by skin. Non-hazardous in case of inhalation. Corrosive to skin and eyes on contact. Liquid or spray mist may produce tissue damage particularly on mucous membranes of eyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Carcinogenic Effects Data CARCINOGENIC EFFECTS: Classified None. by NIOSH [Isopropyl Alcohol]. Classified 3 (Not classifiable for human.) by IARC [Isopropyl Alcohol]. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. Medical Conditions Aggravated Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or by Overexposure: prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection. Overexposure /Signs/Symptoms Not available.

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DirectDetect™ Spike Biacridine Trigger Solution
Europe
Classification Physical/chemical hazards Human health hazards Environmental hazards R11 Highly flammable. Not applicable. Not applicable.

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See Toxicological Information (section 11)

Section 4. First Aid Measures
Notice to Reader Get immediate medical attention. Effects and symptoms Inhalation Non-hazardous in case of inhalation. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by coughing, choking, or shortness of breath. Over-exposure by inhalation may cause respiratory irritation. Ingestion May be fatal if swallowed. May cause burns to mouth, throat, and stomach. Skin Contact Irritation of the product in case of skin contact: Not available. Sensitization of the product: Not available. Non-permeator by skin. Corrosive to skin on contact. Skin contact may produce burns. Eye Contact Corrosive to eyes. Aggravating conditions Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.

First-Aid Measures Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear. Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Skin Contact In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Eye Contact Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention. Notes to Physician Not available. Protection of first-aiders Not available.

Section 5. Fire Fighting Measures
Flammability of the Product Flammable. Flash Points The lowest known value is CLOSED CUP: 11.67°C (53°F). OPEN CUP: 11.9°C (53.4°F). (Cleveland). (Isopropyl

Alcohol)
Fire Hazards in Presence of Various Slightly flammable to flammable in presence of open flames and sparks, of heat, of oxidizing materials. Substances Non-flammable in presence of shocks, of reducing materials, of combustible materials, of organic materials, of metals,

of acids, of alkalis.
Fire Fighting Media Flammable liquid, soluble or dispersed in water. and Instructions SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use alcohol foam, water spray or fog.
Protective Clothing (Fire) Be sure to use an approved/certified respirator or equivalent. Special Remarks on Fire Hazards Flammable/combustible materials.

May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Some may polymerize (P) explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (Acetic Acid, pHix Buffer Grade)

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DirectDetect™ Spike Biacridine Trigger Solution
Hazardous thermal (de)composition These products are carbon oxides (CO, CO2). products

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Section 6. Accidental Release Measures
Personal precautions Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Boots. Environmental Precautions and Flammable liquid. Corrosive liquid. Clean-up Methods Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Use water spray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Neutralize the residue with a dilute solution of sodium carbonate. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Small Spill and Leak Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. If necessary: Neutralize the residue with a dilute solution of sodium carbonate.

Section 7. Handling and Storage
Handling Keep away from heat, sparks and flame. Keep container closed. Use only with adequate ventilation. To avoid fire or explosion, dissipate static electricity during transfer by grounding and bonding containers and equipment before transferring material. Use explosion-proof electrical (ventilating, lighting and material handling) equipment. Storage Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.
Packaging materials Suitable / Not suitable Use original container.

Section 8. Exposure Controls/Personal Protection
Engineering Controls Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Exposure Limit Values
Ingredient Name United States
1) Acetic Acid, pHix Buffer Grade TWA: 10 STEL: 15 TWA: 10 STEL: 37 TWA: 10 STEL: 15 TWA: 10 STEL: 15 Not available. (ppm) from ACGIH (TLV) [United States] [2000] Inhalation (ppb) from OSHA (PEL) [United States] [1989] Inhalation (ppm) from NIOSH [United States] [1998] Inhalation (ppm) from NIOSH [United States] [2000] Inhalation

Occupational Exposure Limits

2) Isopropyl Alcohol

Sweden
1) Acetic Acid, pHix Buffer Grade 2) Isopropyl Alcohol TWA: 5 CEIL: 10 (ppm) from AFS [Sweden] [1996] Inhalation TWA: 150 CEIL: 250 (ppm) from AFS [Sweden] [1996] Inhalation

Denmark
1) Acetic Acid, pHix Buffer Grade 2) Isopropyl Alcohol TWA: 10 (ppm) from Arbejdstilsynet [Denmark] [1996] Inhalation TWA: 200 (ppm) from Arbejdstilsynet [Denmark] [1996] SKIN

Norway
1) Acetic Acid, pHix Buffer Grade 2) Isopropyl Alcohol TWA: 10 (ppm) from Arbeidstilsynet [Norway] [1996] Inhalation TWA: 100 (ppm) from Arbeidstilsynet [Norway] [1996] Inhalation

France
1) Acetic Acid, pHix Buffer Grade 2) Isopropyl Alcohol STEL: 10 (ppm) from INRS [France] [1999] Inhalation STEL: 400 (ppm) from INRS [France] [1999] Inhalation

Netherlands
1) Acetic Acid, pHix Buffer Grade 2) Isopropyl Alcohol TWA: 10 (ppm) from Arbeidsinspectie [Netherlands] [2000] Inhalation TWA: 250 (ppm) from Arbeidsinspectie [Netherlands] [2000] Inhalation

Germany
1) Acetic Acid, pHix Buffer Grade 2) Isopropyl Alcohol TWA: 10 CEIL: 10 (ppm) from BAuA [Germany] [1999] Inhalation TWA: 500 CEIL: 2000 (mg/m3) from BAuA [Germany] [1999] Inhalation

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DirectDetect™ Spike Biacridine Trigger Solution
Personal Protection Eyes Body Hands Respiratory Feet Protective Clothing (Pictograms)

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Splash goggles. Lab coat. Gloves. Respirator is not needed under normal and intended conditions of use, if exposures are kept below established limits. Boots.

Section 9. Physical and Chemical Properties
Physical State and Liquid. Appearance Molecular Weight Not applicable. pH (1% Soln/Water) Acidic. Odor Not available. Taste Not available. Color Not available.

Boiling/Condensation Point The lowest known value is 82.55°C (180.6°F) (Isopropyl Alcohol). Weighted average: 100.19°C (212.3°F) Melting/Freezing Point May start to solidify at -0.1°C (31.8°F) based on data for: Milli-Q Water. Weighted average: -1.01°C (30.2°F) Specific Gravity Weighted average: 1 (Water = 1) Vapor Pressure The highest known value is 4.4 kPa (@ 20°C) (Isopropyl Alcohol). Weighted average: 2.31 kPa (@ 20°C) Vapor Density The highest known value is 2.07 (Air = 1) (Acetic Acid, pHix Buffer Grade). Weighted average: 0.66 (Air = 1) Volatility 100% (v/v). (Acetic Acid, pHix Buffer Grade.) Weighted average: 100% (v/v) Odor Threshold The highest known value is 50 ppm (Isopropyl Alcohol) Weighted average: 17.35 ppm Evaporation Rate 1.7 (Isopropyl Alcohol) compared to (n-BUTYL ACETATE=1) VOC 3 (%) Viscosity Dynamic: The highest known value is 2.1 cP (Isopropyl Alcohol) LogKow The product is more soluble in water. Dispersion Properties See solubility in water, methanol, diethyl ether, n-octanol. Solubility Easily soluble in cold water, hot water, methanol, diethyl ether. Partially soluble in n-octanol.

Section 10. Stability and Reactivity
Stability and Reactivity The product is stable. Conditions to avoid Not available. Materials to avoid Slightly reactive to reactive with oxidizing agents, metals, acids, alkalis. Hazardous Decomposition These products are carbon oxides (CO, CO2). Products

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Section 11. Toxicological Information
Toxicity to Animals Acute oral toxicity (LD50): 3310 mg/kg [Rat]. (Acetic Acid, pHix Buffer Grade). Acute dermal toxicity (LD50): 1060 mg/kg [Rat]. (Acetic Acid, pHix Buffer Grade). Chronic Effects on Humans CARCINOGENIC EFFECTS: Classified None. by NIOSH [Isopropyl Alcohol]. Classified 3 (Not classifiable for human.) by IARC [Isopropyl Alcohol]. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [PROVEN] [Isopropyl Alcohol]. Other Toxic Effects on Humans Slightly hazardous in case of ingestion. Non-irritant for lungs. Special Remarks on Toxicity to Not available. Animals Special Remarks on Chronic 0900 Detected in maternal milk in humain. Effects on Humans (Isopropyl Alcohol) Special Remarks on Other Toxic Exposure can cause nausea, headache and vomiting. (Isopropyl Alcohol) Effects on Humans

Section 12. Ecological Information
Mobility Not available. Persistence/degradability Not available. Bioaccumulative potential Not available. Ecotoxicity Not available. Germany water class VCI WGK: No products were found.

Section 13. Disposal Considerations
Waste Information Waste must be disposed of in accordance with federal, state and local environmental control regulations. Waste Stream Not available. Consult your local or regional authorities.

Section 14. Transport Information
Contact the supplier for all information regarding the proper transportation method for this material.
1

Section 15. Regulatory Information

Label Requirements (Europe)

R11- Highly flammable. S2- Keep out of the reach of children.

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Highly flammable

HCS Classification Flammable liquid having a flash point lower than 37.8°C (100°F). Target organ effects. Reproductive toxins. Corrosive material
U.S. Federal Regulations TSCA 4(a) final test rules: Isopropyl Alcohol TSCA 8(b) inventory: Milli-Q Water; Acetic Acid, pHix Buffer Grade; Isopropyl Alcohol TSCA 12(b) one time export: Isopropyl Alcohol SARA 302/304/311/312 extremely hazardous substances: No products were found. SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: Acetic Acid, pHix Buffer Grade; Isopropyl Alcohol SARA 311/312 MSDS distribution - chemical inventory - hazard identification: Acetic Acid, pHix Buffer Grade: fire, immediate health hazard, delayed health hazard; Isopropyl Alcohol: fire, immediate health hazard, delayed health hazard SARA 313 toxic chemical notification and release reporting: Isopropyl Alcohol 1% Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: Acetic Acid, pHix Buffer Grade Clean air act (CAA) 112 accidental release prevention: No products were found. Clean air act (CAA) 112 regulated flammable substances: No products were found. Clean air act (CAA) 112 regulated toxic substances: No products were found. WHMIS (Canada) CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2A: Material causing other toxic effects (VERY TOXIC). CLASS E: Corrosive liquid. CEPA DSL: Milli-Q Water; Acetic Acid, pHix Buffer Grade; Isopropyl Alcohol International Regulations EINECS Not available. DSCL (EEC) R11- Highly flammable. International Lists Australia (NICNAS): Milli-Q Water; Acetic Acid, pHix Buffer Grade; Isopropyl Alcohol Germany water class: Acetic Acid, pHix Buffer Grade; Isopropyl Alcohol Korea (TCCL): Milli-Q Water; Acetic Acid, pHix Buffer Grade; Isopropyl Alcohol Philippines (RA6969): Milli-Q Water; Acetic Acid, pHix Buffer Grade; Isopropyl Alcohol State Regulations Pennsylvania RTK: Acetic Acid, pHix Buffer Grade: (environmental hazard, generic environmental hazard); Isopropyl Alcohol: (environmental hazard, generic environmental hazard) Massachusetts RTK: Acetic Acid, pHix Buffer Grade; Isopropyl Alcohol New Jersey: Acetic Acid, pHix Buffer Grade; Isopropyl Alcohol California prop. 65: No products were found.

Section 16. Other Information
Hazardous Material Information System (U.S.A.)
Health Fire Hazard Reactivity Personal Protection

*

1 1 0

National Fire Protection Association (U.S.A.)
Health

1 1 0

Fire Hazard Reactivity Specific Hazard

References Not available. History of Document Changes Any information changes since last document version are marked with a triangle symbol.
Full text of R-Phrases referenced under headings 2 and 3: Harmful in contact with skin. Causes severe burns. Irritating to eyes and respiratory system.

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Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.

Validated by Pierce Administration on 11/4/2002.

Verified by Pierce Administration.

Date of Previous Issue No Previous Validation

Printed 11/13/2002. Version 0.01 Notice to Reader To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.


				
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