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					功能醫學臨床應用研討課程




         Environmental
         Accumulations

        Even a low rate of
        accumulation may
         over time lead to
          the barrel (the
              immune
        system ) becoming
        full to overflowing




             2009/5/11          Dr.Louis TakCho Lee        1




                  DID YOU KNOW? Humans:
             • are made of 60 - 90% water?
             • cause 90% of their diseases because of
                 what or how they drink?
             •   in the course of their lives drink
                 approximately 600 times their own
                 weight in water?
             •   can live for several weeks without food
                 but can only live a few days without
                 water?

             2009/5/11          Dr.Louis TakCho Lee        2




                                                               1
功能醫學臨床應用研討課程




            VISUALIZATION OF MERCURY EMITTING
                 FROM A DENTAL AMALGAM
          From: www.
          uninformed
          concent.com
          David
          Kennedy’s
          IAOMT tape
        IN SPITE OF THE
           OBVIOUS
           EMISSION OF
           Hg VAPORS
           FROM
           DENTAL
           AMALGAM
           THE FDA HAS
           STEADFASTL
           Y REFUSED
           TO TEST
           THEM FOR
              2009/5/11        Dr.Louis TakCho Lee         3
           SAFETY!




               The population characteristics are
                 consistent in both disorders.
           First, the prevalence rate of autism closely matches
          the introduction and spread of thimerosal-
          containing vaccines. Autism was first discovered
          in the early 1940s among children born in the
          1930s; thimerosal was first introduced into
          vaccines in the 1930s. Prior to 1970, autism was
          estimated at 1 in 2000 children; studies after
          1970 showed a higher prevalence of 1 in 1000.
          This was also a period of increased immunization
          of American children. In 1996, the NIH estimated
          the rate of autism to be 1 in 500, and just
          recently the CDC has found 1 in 150 children 4
            2009/5/11           Dr.Louis TakCho Lee
          affected




                                                                  2
功能醫學臨床應用研討課程




              FDA recently acknowledged
        That in the first six months of life children get more
          mercury than is considered safe by the EPA. The
          truth is that sometimes kids go to their doctor's
          office and get four or five vaccines at the same
          time. A child received vaccines for nine different
          diseases in one day. He may have been exposed to
          62.5 mcg of mercury in one day through his
          vaccines. According to his weight, the maximum
          safe level of mercury he should be exposed to in
          one dayis1.51mcg. This is forty-one times the
                               Dr.Louis can
          amount at which harmTakCho Leebe caused.
           2009/5/11                                       5




          2009/5/11          Dr.Louis TakCho Lee         6




                                                                 3
功能醫學臨床應用研討課程




                      Effect of Mercury on Neuron




          2009/5/11          Dr.Louis TakCho Lee   7




          whereas the apolipoprotein Ee2 allele
         reduces the risk of developing
         Alzheimer's disease. Some investigators
         have suggested that apolipoprotein Ee4
         has a reduced ability to bind metals
         like mercury and therefore explain the
         higher risk for Alzheimer's disease.
         (Mutter et al., Neuro Endocrinol Lett.
         25(5):331-9, 2004)
          2009/5/11          Dr.Louis TakCho Lee   8




                                                       4
功能醫學臨床應用研討課程




          Overlooked Effect of Mercury
               In another study nearly 50% of
              dental staff tested positive for
              Anti-Nuclear Antibody (ANA)
              titers compared to less than 1% of
              the general population. (Huggins &
              Levy, 1999)

           2009/5/11                    Dr.Louis TakCho Lee                    9




                                                      Heavy Metals
                                                         重金屬

                   Leaky Gut                                  Gut Endotoxins
                     腸漏症                                          腸道毒素


             Allergies                                               Xeno-hormones
              過敏原                                                     環境化學荷爾蒙


         Preservatives                                                Pesticides
            防腐劑                                                         殺蟲劑


               Medications                                     Pollution
                  藥物                                            空氣污染

                               Solvents
           2009/5/11           有機溶劑  Dr.Louis TakCho Lee                      10




                                                                                     5
功能醫學臨床應用研討課程




              Gap between Health, Wellness &
                        Sickness
                                                      Wellness
                                  疾病,
                                                       , 15%,
                                  25%
                                                                   Wellness
                                                                   亞健康
                                                                   疾病

                                      亞健康,
                                      60%,

        Wellness           亞健康            疾病

        15% 2009/5/11     60%       25% TakCho Lee
                                    Dr.Louis                            11




                     食物及環境是自由基產生的主要來源
                                          蔬果的
                                         抗氧化作用               食物
                  化學物質




         輻射線                                        蛋白質氧化



                                                                  粒腺體

              病毒

                          基因損傷
                                 reactive oxygen species (ROS)
              2009/5/11              Dr.Louis TakCho Lee                12




                                                                              6
功能醫學臨床應用研討課程




          2009/5/11   Dr.Louis TakCho Lee   13




          2009/5/11   Dr.Louis TakCho Lee   14




                                                 7
功能醫學臨床應用研討課程




                      自由基對細胞及組織的破壞




         脂質過氧化        蛋白質變性    酶失去作用                基因損傷


                      細胞損傷


         心血管病變
                                                           癌症
                                             老化

          2009/5/11           Dr.Louis TakCho Lee          15




                              Junk Food, Junk Look!



          2009/5/11           Dr.Louis TakCho Lee          16




                                                                8
功能醫學臨床應用研討課程




                                                           心血管療程
                         適應症狀
                         1.        年齡:男性>40 或女性>50 或停經後女性
                         2.        高血壓:收縮壓>130mmHg 或舒張壓>85mmHg, CAD, CVD..
                         3.        糖尿病:空腹血漿葡萄糖濃度>126mg/dL
                         4.        有心臟病家族史者或本身有心臟病史者
                         5.        肥胖:BMI>25 或男性腰圍>40 吋或腰臀比>0.95;或女性腰圍>35 吋或腰臀比>0.8
                         6.        抽煙者
                         7.        高血脂:空腹三酸甘油脂>160mg/dL 或空腹總膽固醇>200mg/dL
                         8.        長期壓力過大者




                                         心血管基因分析                   全套心血管系統綜合分析




                 營養與消化                      解毒及排泄                  免疫失衡             內分泌失衡
                   、  、
                 肥胖 疲勞 營養不良、                抽煙者、環境敏感、慢            疲勞、軟弱無力、代謝        中廣身材、高血壓、高
                 情緒不穩                       性發炎、抗氧化物攝取            障礙                澱粉飲食者、糖尿病症
                                            量低                                      狀




                      胺基酸平衡性分析               抗氧化維生素分析                   代謝功能分析       血糖代謝異常分析



                 高血壓、慢性發炎、憂                    氧化壓力分析             壓力(精神、情緒或生        男性>45 歲、女性>50
                 心症、皮膚炎或搔癢                                        理)、疲勞、失眠           、     、
                                                                                    歲 近更年期 更年期、
                                                                                    更年期後
                                            抽煙者、蛀牙補綴者、
                                            毒性物質暴露


                      必需性與代謝性                                     腎上腺皮質壓力分析         全套男性荷爾蒙分析
                      脂肪酸平衡性分析
                                             微量元素平衡性分析                              女生荷爾蒙健康評估
                 腸胃道症狀、不當飲食
                                                                                      停經後荷爾蒙
                                                                                       健康評估

          2009/5/11                               Dr.Louis TakCho Lee                雌激素代謝分析
                                                                                                 17
                      全套腸胃道系統
                        綜合分析




                                                        癌症預防療程
                              適應症狀
                              1. 家族病史、年齡>45 歲者
                              2. 攝取過多動物性脂肪、醃漬、燒烤、煙燻食物;缺乏足夠蔬果與高纖食品
                              3. 肝炎帶原者、肝硬化患者、慢性發炎及感染者、腸胃道潰瘍、肝膽結石、腹部疼痛
                              4. 排便習慣改變、血便、體重突然減輕、大腸息肉、脂肪便、長期下痢
                              5. 過度肥胖(BMI>25)、缺乏運動
                              6.    抽煙、嚼檳榔、酗酒、持續咳嗽超過三個月、咳血或痰有血絲、吞嚥異常、飲食過
                                    熱、口腔白斑症
                              7.    長期環境污染暴露、空氣污染、電磁波或輻射線暴露、煙塵暴露、過度曝曬、長期
                                    染髮、烏腳病流行區居民、長期飲用井水
                              8.    女性:性經驗過早、多重性伴侶、曾有性病感染、初經在 12 歲以前、頭胎晚於三
                                    十歲、多次墮胎、異常陰道出血、乳房腫塊或異常分泌物、下腹脹或疼痛
                              9.    腎結石、膀胱結石、血尿、排尿不順、小便刺痛
                              10.   長期壓力過大、經常性倦怠




                        免疫功能分析                         癌症標記檢查                    抗氧化維生素分析




                營養與消化                      解毒及排泄                 免疫失衡             內分泌失衡
                消化系統症狀、腹瀉、                 抽煙者、肝炎帶原者、           易感染者、冷性特質、        男女性>45 歲、月經週
                便秘、血便、排便習慣                 環境敏感、慢性發炎、           常感冒、家族病史          期紊亂、近更年期,更
                改變                         抗氧化物攝取量低                               年期、更年期後




                      全套腸胃道系統
                                            肝臟解毒功能分析               免疫基因分析          全套男性荷爾蒙分析
                        綜合分析


                消化系統症狀、胃炎、                   氧化壓力分析             肝癌家族史、肝炎帶原         女性荷爾蒙健康評估
                胃潰瘍、胃燒灼                                         者、排毒能力不佳者
                                           抽煙者、常暴露於環境                               停經後荷爾蒙
                                           毒素、記憶力衰退、環                                健康評估
                                           境敏感、蛀牙補綴者
                                                                                    雌激素代謝分析
          2009/5/11 胃幽門螺旋桿菌                       Dr.Louis TakCho Lee
                                                                   解毒基因分析                        18
                       抗體分析
                                           微量元素平衡性分析




                                                                                                      9
功能醫學臨床應用研討課程




               Diseases Caused by Oxidative Stress

             Cancer                             Immune weakness
             Heart attack                       Depression
             Stroke                             Cataracts
             Alzheimer’s disease                Arthritis
             Macular degeneration               Osteoporosis
             Eclampsia                          Asthma
             ARDS/Septic shock                  Aging


          2009/5/11           Dr.Louis TakCho Lee                 19




              Important detoxification
                  organ systems
                             KIDNEY
                             LIVER
                             BOWEL
                             SKIN
                             ANS

          2009/5/11           Dr.Louis TakCho Lee                 20




                                                                       10
功能醫學臨床應用研討課程




                              Antioxidants
                 Endogenous                             Exogenous
               Catalase
               Glutathione peroxidase               Phytonutrients come
               Glutathione S-                       from fruits, vegetables,
               transferase                          and grains
               Superoxide dismutase
               Peroxisomes
               Ceruloplamin
               Proteases, Glycosylases
               Ferritin, transferrin
          2009/5/11               Dr.Louis TakCho Lee                     21




         DetoxiGenomic ProfileTM (Blood) 解毒
               功能基因預測分析 (血液)

              需要了解肝臟先天的解毒功能是否正
              常。因此要分析暴露於環境毒素下,會
              增加肝臟解毒風險的相關單一核 苷酸多
              型性變化(SNPs),以及鑑定個人對藥物
              反應的潛在敏感性。再根據個人之遺傳
              風險,提供飲食、生活型態、營養補充
              品、藥品及後續追蹤檢查之相關建議,
              以減輕肝臟負擔重拾彩色人生。

          2009/5/11               Dr.Louis TakCho Lee                     22




                                                                               11
功能醫學臨床應用研討課程




                        DETOXIFICATION

                  PHASE I : OXIDATION– Enz.
                  PHASE II : CONJUGATION
                  PHASE III : ANTIPORTER



          2009/5/11              Dr.Louis TakCho Lee                 23




                     PATHWAY OF
                HEPATIC DETOXIFICATION
                                                                Water
                                  Activated
         Fat Soluble                                           Soluble
                                Intermediate
            Toxin                                             Compound




                      Phase I                           Phase II
         Hydroxylation Reactions                       Conjugation
         Cytochrome P450 enzymes                        Reactions

          2009/5/11              Dr.Louis TakCho Lee                 24




                                                                          12
功能醫學臨床應用研討課程




          2009/5/11   Dr.Louis TakCho Lee   25




          2009/5/11   Dr.Louis TakCho Lee   26




                                                 13
功能醫學臨床應用研討課程




          2009/5/11                  Dr.Louis TakCho Lee                   27
                  Liver detoxification pathways and supportive nutrients




                                     NQO1
            Benzene, quinine ,dioxin, PAH, oxidant
            Benzene
           stress
            +/+ Caucasian 2%; Asian 20%
            NAD(P)H
            B2, Mg, 十字花科
            Check Li.Dtx.Pr.; --- SOD, GSH, GSHPx, f-
           Thiols, MDA;
            Check environmental Toxic……..Hg, Pb,
           As…
          2009/5/11                  Dr.Louis TakCho Lee                   28




                                                                                14
功能醫學臨床應用研討課程




                            CYP1A1-2
         Air pollution; smoke, charcoal foods, PAHs, dioxin,
         TCCD, PCB,
         Sino 3-6%+/+; 40-45%+/-; 50-55%-/-
         CYP1A1-2-hydroxylatio – 2-OHE & COMT to
         2MeOE
         Over activated CYP1A1-2 = carcinogen
         Female smoke since18y/o breast ca.=3.61:1; PMS=1.61x but
         smoke >25y = 5.22:1;
         ACE, I3C,十字花科,green tea,
         Check M/F Hormone Health Assessment;
         Li.Dtx.Pr;En.T.A.;

          2009/5/11             Dr.Louis TakCho Lee            29




                              GSTM1
          A lots of cancers : lung, liver, gastric,U.bladder,
          Breast, Pschio.,MS;
          Phase 11 -- A lots of toxic………………….etc.,
          Smoker S.C.C.H.N. hi. 17% lung ca. &
          U.bladder ca.,
          If also + GSTT1 (Null), cancer will be more hi.,
          50% of P’ Null
          GSH, NAC, AntiOxidants, silymarin, green tea,
          avoid toxic food and lifestyle correct,
          2009/5/11             Dr.Louis TakCho Lee            30




                                                                    15
功能醫學臨床應用研討課程




                        GST-T1
          > lung, larynx, U.blader, Prostate, Cx.Ca.,
          Phase 11-
          46-58% P’ Null!
          Null= >2.7x SCCHN, smoker >3.7x
          If + GSTM1, ca more hi., MDS, AA,
          Br.asthma.>>++++
          GSH,十字花科,soy, garlic, onion, fruits, ACE, NAC,
          silymarin, green tea,
          Avoid toxic lifestyle,
          Check GST-RBC….etc., as formers.
          2009/5/11        Dr.Louis TakCho Lee         31




          2009/5/11        Dr.Louis TakCho Lee         32
                                                 瀚仕功能性醫學研究所




                                                              16
功能醫學臨床應用研討課程




        從哪裡獲得抗氧化物??Not enough




          2009/5/11   Dr.Louis TakCho Lee   33




          2009/5/11   Dr.Louis TakCho Lee   34




                                                 17
功能醫學臨床應用研討課程




              Phase 1 Detox -- Anti Toxic
              meterial(metabolism) with enzyme
              Phase 11Detox—conjugating to
              change(enviromental– xenobiotics, etc.,)
              99%DNA are same but polymorphism



          2009/5/11           Dr.Louis TakCho Lee        35




         Geno or Environmental / Lifestyle??


                                      2/8



          2009/5/11           Dr.Louis TakCho Lee        36




                                                              18
功能醫學臨床應用研討課程




              Phase II Nutrients:
              Phase Nutrients:         Antioxidants:
                                        Antioxidants:           Phase II Nutrients:
                                                                Phase II Nutrients:
                 B vitamins
                 B vitamins            Phytonutrients
                                       Phytonutrients                  Glycine
                                                                       Glycine
                Glutathione
                Glutathione             Vitamin C, E
                                        Vitamin C, E                     NAC
                                                                         NAC
                Flavanoids
                 Flavanoids               Minerals
                                          Minerals                    B vitamins
                                                                      B vitamins


                     Phase II
                     Phase                                      Phase II
                                                                Phase II
        Toxins (Cytochrome P450)            Intermediate (Conjugation Pathways)
                                            Intermediate (Conjugation Pathways) Excretion:
        Toxins (Cytochrome P450)                                                 Excretion:
               Reactions: Oxidation
               Reactions: Oxidation          Metabolite
                                              Metabolite       Sulfation
                                                                Sulfation         Blood
                                                                                   Blood
                                                         Amino Acid conjugation
                                                          Amino Acid conjugation  Urine
                                                                                   Urine
                                                            Glucronidation
                                                             Glucronidation       Feces
                                                                                   Feces
                                                              Glutathione
                                                              Glutathione
                                                             Metnhylation
                                                              Metnhylation



                     Free
                     Free                             ROS
                                                      ROS
                    Radicals
                    Radicals

                                    Cell damage
                                    Cell damage
              2009/5/11                         Dr.Louis TakCho Lee                   37




                                       FEMALE




              2009/5/11                         Dr.Louis TakCho Lee                   38




                                                                                              19
功能醫學臨床應用研討課程




        Birth-Hair Hg Levels In Infants From Mothers
              With More Than Eight Amalgams
                Data (Hg ppm) was
                                                     7
                selected from only
                mothers who had 8 to                 6
                15 amalgam fillings to               5
                determine if these
                                                     4                          Normals
                extremes showed a
                                                     3                          Autistics
                more definite trend on
                the differences                      2
                between autistic and
                                                     1
                normal infants. The
                ratio was 12:1.                      0
              2009/5/11                     Dr.Louis TakCho Lee                   39




                     BIRTH-HAIR MERCURY BY
                       SEVERITY OF AUTISM
                             1.4

                             1.2                  Female
                                                  Male

        Hair Hg               1
        level
        (ppm)                0.8
        Data from Amy
        Holmes, Mark
                             0.6
        Blaxill & Boyd
        Haley, Int. J.       0.4
        Tocicology v22, in
        press, 2003.         0.2

                              0
                                     Mild                Moderate    Severe
              2009/5/11            Mean=0.71Dr.Louis TakCho Lee
                                                        Mean=0.46   Mean=0.21     40
                                     n=27                  n=43       n=24




                                                                                            20
功能醫學臨床應用研討課程




                                                       MOST VACCINES
                                                       CONTAIN TRACES OF
                                                       THIMEROSAL EVEN IF IT
                                                       IS NOT ADDED AS A
                                                       PRESERVATIVE.




                                                   The vaccine thimerosal
                                                   concentration was (is) 125,000
                                                   to 250,000 nanomolar!
          2009/5/11          Dr.Louis TakCho Lee                       41




                      Molecular Toxicology
          It has been found that 98% of autistic
         children treated in a medical center have
         defects in the major metal binding protein
         metallothionein. (William Walsh) A subsequent
         animal study shows that metallothionein-null
         mice are susceptible to mercury toxicity (in
         behavioral alterations) from exposure to
         mercury vapor at a human-relevant
         concentration. (Yoshida et al., 2004) This may explain
         why children with MT defect are susceptible to
         the mercury contained inLee
         2009/5/11          Dr.Louis TakCho
                                            vaccines used prior
                                                             42

         to 2000.




                                                                                    21
功能醫學臨床應用研討課程




                                       Observation
           Autistic infants in utero appear to have
          an impaired ability to excrete mercury
          when compared to normal children!
           New concept: Low mercury levels in the
          hair and blood do not imply lack of toxic
          mercury exposure or retention in the body!


             2009/5/11                      Dr.Louis TakCho Lee                             43




        90.00%
                                           鉛Pb
        80.00%                                   汞Hg
                               砷As

        70.00%
                                                                  錫Sn
        60.00%   鋁Al     銻Sb
                                                                                                 鋁Al
        50.00%                                                                                   銻Sb
                                                                              鎘Cd                砷As
        40.00%
                                                                                    鎢Tw          鉍Bi
        30.00%                                                                                   鉛Pb
                                                        鎳Ni
                                                                                                 汞Hg
        20.00%                                                                                   鎳Ni
                                     鉍Bi                                                  銀Ag    錫Sn
        10.00%                                                                                   鈦Ti
                                                                                                 鎘Cd
        0.00%
                                                                                                 鎢Tw
                 鋁Al     銻Sb 砷As 鉍Bi       鉛Pb 汞Hg 鎳Ni            錫Sn   鈦Ti   鎘Cd 鎢Tw 銀Ag
                                                                                                 銀Ag
             2009/5/11
                                           2007
                                            Dr.Louis TakCho Lee                             44




                                                                                                       22
功能醫學臨床應用研討課程




                   Recommended Medical Tests
           Urine Peptides
           Urine Organic Acid
           Comprehensive Stool Analysis
           Genomics
           Complete Viral Panel
           Toxic Metals / Red Blood Cell Elements
           Vitamin Panel (could be part of another test)
           Essential Fatty Acids RBC test (blood)
           Lymphocyte Subsets TH1/TH2
           Food Allergy Panel
           Plasma Sulfate & Plasma Cysteine
           Liver & Kidney Functions (from any lab)
           Immunoglobin profiles (depends on your doctor)
           Thyroid Study (from any lab)
           Ammonia Levels (from any lab)
           Blood clotting profiles (from any lab)
           Anti Mylen Basic Protein #1056 –Specialty Labs
           MAJOR TESTS: 24 hour EEG, MRI, Spect Scan (after age 6) and Landau Klefner/Fragile X, Rhetts
           Syndrome
           IgG allergens: Yeast · Refined sugars · Dyes / Additives / ”natural flavors
        There are thousands more…..
                                    doctor’
        ALL tests above require a doctor’s prescription

               2009/5/11                        Dr.Louis TakCho Lee                              45




                             Internal Environments

                           Biological “Milieus” of Patients
                                    “Symbiotics”




               2009/5/11                        Dr.Louis TakCho Lee                              46




                                                                                                          23
功能醫學臨床應用研討課程




                ImBalance of the Symbiotics
               Poor diet
               Stress
               Toxins
               Symbiosis shifts




          2009/5/11          Dr.Louis TakCho Lee    47




                      Pleomorphic *SANUM
            Homeopathic -- --- -- Isopathic(Nodos) “like
           cures like” stimulate the body’s own natural
           tendency to self-heal!

           Antihomotoxic («modern homeopathic»)
           medicines



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功能醫學臨床應用研討課程




                      Homotoxicology
          The theory of disease developed by Dr.
          Hans-Heinrich Reckeweg (1905-1985),




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          2009/5/11       Dr.Louis TakCho Lee      50




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功能醫學臨床應用研討課程




                                   Supplements
           Some of the most commonly missing and desperately needed supplements for children
           on the spectrum are:
            1. Calcium
            2. Zinc
            3. Magnesium (Citrate & Glycenate)
            4. Cod liver oil (make sure it is tested and MERCURY FREE)
            5. Essential fatty acid (EFA Powder)
            6. Selenium
            7. Probiotics (ProBioGold)
            8. B6 (SuperNuThera) & B12
            9. TMG or DMG
            10.Vitamin C
            11. L-Gluthathione (supplement or topical crème)
            12.Carnitine
            13. Taurine & Folinic Acid (amino acids)
            14.More >>>>>>>>>>>>>>>>>>..>>>>>>>>>>>>>>>>>>>>>>>>>>>
           The “Sometimes” Needed / and “Sometimes Very Helpful” Category are:
                And sometimes, a digestive enzyme (Enzymaid Complete w/ DPPIV)
                Colostrum / Transfer Factor
                Magnesium Sulfate crème or Epsom salt baths for children who are sensitive to phenols


          2009/5/11                          Dr.Louis TakCho Lee                                 51




                      Why Sulfate is Necessary?
          To maintain the slipperiness of gut mucins which
          support gut permeability
          Sulfate activates some hormones e.g..
          Cholecystokinine, gastrin etc.
          Necessary for detoxification( allergic, HMI)
          Example:
            Increased dopamine is responsible for
            stereotypic movements and behavior; sulfate
          needed to eliminate it.

          2009/5/11                          Dr.Louis TakCho Lee                                 52




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功能醫學臨床應用研討課程




                                  Primary Source of Sulfur
           (I) Sulfur containing Amino Acids. (SAA)
                      e.g. Cysteine, Cystine, Methionine, Taurine

           (II) Organo Sulfur
                     e.g. Allicin, Diallyl Sulfide,
                          Isolthiocyanates etc.. Found in garlic, onion
                          and other fruits and vegetables.

           (III) Other Sources

                         Methylsulfonylmethane (MSM), DMSO,
                         glucosamine sulfate, glutathione (GSH),
                         N Acetyl Cysteine (NAC)
                         Magnesium Sulfate

          (IV) Foods

                      Corn, Sunflower seeds, oats, cashews, walnuts,
             almonds, sesame seeds etc.
                                                                          TKA 2




           Plasma Sulphates and Glutathione
                     in Children
                                  Control            Autistic
                                  (n 24)             (n 41)
        Some autistics had normal levels, but some had
          very low levels:
        Sulphate (free)1    1.8-10   0.4-1.9 25% low
        Sulphate (total)1 1400-3000 94-310 43% v. low
        Glutathione (total)2 3.8-5.5 1.2-4.1 46% low
        1 (nmole/mg    protein)     2   (µmole/ml) Lee
           2009/5/11                      Dr.Louis TakCho                   54
                                                                          TKA 4




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功能醫學臨床應用研討課程




              ENZYME REACTIONS
               Many detoxification mechanisms
              are enzymatic. They often require
              coenzymes and / or mineral
              activators.




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                      Examples 0f Vitamin-
                      Coenzyme Reactions
              B-2 as FMN aids formation of
             pyridoxal 5 phosphate from B-6
               B-12 and folic acid as
             tetrahydrofolate are needed for
             methionine metabolism

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功能醫學臨床應用研討課程




           Examples of Mineral
         dependent enzymatic steps
              Mg: glutathione synthetase
              Zn: peptidases
              Cu: dopamine hydroxylase
              Cu, Zn: superoxide dismutase (SOD)
              SE: gluatathione peroxidase



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                      Steps necessary for
                         detoxification
              Organ systems                   Allergies treated
              working                         Electron support
              Coupling agent                  Drug uptake enhanced
              Mineral replacement
                                              Infection treated
              Vitamin supplement
              Glutathione
              enhancement

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功能醫學臨床應用研討課程




                        Coupling agents
               DMSA -- Homeopathic DMSA-D3,D6
               DMPS
               EDTA
               CHLORELLA
               CILANTRO
               METAL FREE

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                      Mineral replacement
            SELENIUM
            MAGESIUM
            POTASSIUM
            COPPER
            Zn
          Not at the same time of Chelation
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功能醫學臨床應用研討課程




                      Vitamin supplements

                      B VITAMINS
                      VIT. E
                      VIT C


          2009/5/11          Dr.Louis TakCho Lee   61




              Glutathione enhancement

                      WHEY PROTEIN
                      SUPPLEMENTS
                      IV


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功能醫學臨床應用研討課程




                       Detoxification Protocol
                             Summary




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                  1.   Hydration, Hydration, &
                               Hydration

               No water, no detoxification
               Quality: microclustered
               Amount: one half body weight
              in ounces


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功能醫學臨床應用研討課程




                         2. Coupling Agents
                      CILANTRO
                        MarcoPharma
                        Dragon River (tincture-blood brain barrier?)
                        MIC INT.
                      DMPS
                        Only if levels aren’t dropping


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                         3. Mineral Support
                      Magnesium,Potassium
                      upx
                      Ionized Trace Elements
                      MVM
                      Water OZ (various minerals)
                      Selenium
                      Copper
                      Iron –Barley Green
          2009/5/11                 Dr.Louis TakCho Lee           66




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功能醫學臨床應用研討課程




                 4. Kidney & Liver Support
              KIDNEY                     LIVER
              Solidago                   Hepatica
              Renew                      Renew




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                      5. Bowel Support

               Verify 1 to 2 bowel movements
              /day avoid constipation
               Bowel cleanse
               Multiple herbal fibers


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功能醫學臨床應用研討課程




          6. Drug Uptake Enhancement

                Massage LI 4 (Ho Ku point)
                Herbal
                Hot shower or Herbal sauna



          2009/5/11       Dr.Louis TakCho Lee    69




                       7. B Vitamins

                B -6
                B-12
                B Complex
                IM injections weekly as needed


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功能醫學臨床應用研討課程




                      8. Test for Bugs/Infections

               MOST COMMON
               Viruses
               Mycobacterium
               Chlamydia Trachomotis
               Lymes
               Bacteria
          2009/5/11                          Dr.Louis TakCho Lee     71




                            9. Treatment for Bugs
               Virus
                      MIC EPA (Omura,Metagenics)
                      Shark Liver oil (Ecomer)

               Bacteria
                      Antibiotics (Trimox,doxycycline)
                      Monastary of Herbs

               Spirochetes
                      Doxycycline
                      Monastary of Herbs
               Mycobacterium
                      Mayan Life
                      Monastary of Herbs
                      Product 10
                      Uva Use
               Parasites
          2009/5/11
                      Castor oil             Dr.Louis TakCho Lee     72
                      Black walnut hull tincture, wormwood, cloves




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功能醫學臨床應用研討課程




                      10. Lymphatic Drainage
                      Light beam generator with Ozone
                      (With or without massage)
                      Lymphonest
                      Chi machine --- ELH
                      Rebounder
                      Dry brush
                      Homeopathic Drainage --- Apex
          2009/5/11             Dr.Louis TakCho Lee   73




                                                           37

				
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