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Beckman Coulter
TM

Kit MSDS
Doc. ID: 33320-75: Rev. AA

Product Information
Product Name Part Number Series Name:

TROPONIN I
33320 ACCESS®

Doc. ID 33320-75 AA Issued (day/month/year) 09/12/1998

Components
Description TROPONIN TROPONIN TROPONIN TROPONIN TROPONIN I I I I I (Compartment (Compartment (Compartment (Compartment (Compartment R1a) R1b) R1c) R1d) R1e)

Transport Information
Transportation of this product is not regulated under ICAO, IATA, US DOT, European ADR or Canadian TDG.

©1998 Beckman Coulter, Inc.
Global MSDS – English

Page 2 of 27

@

Beckman Coulter
TM

MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification

Product Name

TROPONIN I (Compartment R1a)
Component of P/N 33320 ACCESS® Manufactured for Beckman Coulter, Inc. Fullerton, CA 92834-3100, U.S.A.

TROPONIN I Doc. ID 33320-75 AA Issued (day/month/year) 09/12/1998

Part Number Series Name Manufacturer

Distributor and Emergency Phone No.

¤

Refer to attached list, Document ID: 472050, for local distributor and emergency phone numbers.

Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None

Section 3 Hazards Identification
Emergency Overview Reddish-brown; Opaque; Liquid; Odorless Nonflammable aqueous solution. Does not meet EU, OSHA or WHMIS criteria for hazardous materials. Contains animal material which may have come in contact with human material.

Physical Hazards Potential Health Effects Summary

No physical hazards were determined from a review of available literature. This product does not meet EU, OSHA or WHMIS criteria for hazardous materials. However, it does contain animal material which may have come in contact with human material during processing and should be considered potentially infectious. EU: Not applicable WHMIS: Exempt US OSHA: Not applicable

Product Hazard Classifications

Section 4 First Aid Measures
Inhalation Eye Contact If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. If product is splashed in eyes, wash eyes under gently running water for 15 minutes or longer, making sure that the eyelids are held open. Obtain medical attention.

TROPONIN I TROPONIN I (Compartment R1a)

Doc. ID: 33320-75 AA

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Section 4 First Aid Measures (Continued)
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. Then gently wash skin with soap and water; rinse well. If product contacted broken skin, soak the wound area with a 1:10 dilution of fresh household bleach for 10 minutes. Rinse with water to remove residual bleach. (Remove contaminated clothing and disinfect with a 1:10 dilution of fresh household bleach.) Obtain medical attention. If ingested, wash out mouth with water. Call a physician.

Ingestion

Section 5 Fire Fighting Measures
Flash Point Flammable Limits Autoignition Temp. Extinguishing Media Special Fire and Explosion Hazards Hazardous Combustion Products Protective Equipment for Firefighters Not applicable Not applicable Not applicable Use extinguishing media suitable for surrounding fire. No special hazards determined. Due to the nature and volume of this product, the type and amount of combustion products are negligible. Self-contained breathing apparatus is recommended for firefighters.

Section 6 Accidential Release Measures
Personal Precautions Spill and Leak Procedures Use universal precautions during clean up procedures. As a precautionary measure, treat spilled material with a 1:10 bleach/water solution. Absorb liquid and place in container suitable for disposal. Avoid generation of aerosols during clean up. Comply with applicable waste disposal regulations. Contain spill to prevent migration.

Environmental Precautions

Section 7 Handling and Storage
Handling Precautions Recommended Storage Conditions This product should be handled as though capable of transmitting infectious diseases. Universal precautions should be followed when using this product. Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling.

Section 8 Exposure Controls and Personal Protection
Exposure Limits US OSHA: ACGIH: DFG MAK: None established None established None established

TROPONIN I TROPONIN I (Compartment R1a)

Doc. ID: 33320-75 AA

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Section 8 Exposure Controls and Personal Protection (Continued)
Engineering Controls Respiratory Protection Use in well ventilated area. Under normal conditions, the use of this product should not require respiratory protection. If overexposure should occur and ventilation is not adequate to maintain airborne concentrations at acceptable levels, the use of respiratory protection should be evaluated by a qualified professional. Safety glasses or chemical goggles should be worn to prevent eye contact. Impervious gloves, such as latex or equivalent, should be worn to prevent skin contact.

Eye Protection Skin Protection

Section 9 Physical and Chemical Properties
Physical State Color Transparency Odor Odor Threshold pH Boiling Point Melting Point Specific Gravity Vapor Pressure Vapor Density Evaporation Rate Coefficient of Water/Oil Distribution Percent Volatiles Solubility Water Organic Matrix is miscible Not available Liquid Reddish-brown Opaque Odorless Not applicable 7.4 Not available Not available 1.01 @20°C Not available Not available Not available Not available Not applicable

Section 10 Stability and Reactivity
Stability Hazardous Incompatibilities Stable under normal temperatures and pressures. Metals and metallic compounds Sodium azide forms explosive compounds with heavy metals. Repeated contact of low concentrations of azide with lead and copper commonly found in plumbing drains may result in the build up of shock sensitive compounds. When stored as labeled, no known hazardous decomposition products are formed during the shelf-life of this product. Keep away from incompatible material.

Hazardous Decomposition Products Conditions to Avoid

TROPONIN I TROPONIN I (Compartment R1a)

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Section 11 Toxicological Information
Toxicity Data for Hazardous Ingredients Primary Routes of Exposure Not applicable Common routes of entry include inhalation, ingestion and eye/skin contact. Specific paths of concern for potentially infectious materials are skin puncture, contact with broken skin, contact with mucous membranes and inhalation of aerosolized material. This product contains materials of animal origin, some of which may have come into contact with human material during processing. The product should be considered as potentially capable of transmitting infectious diseases. Effects are similar to those for acute exposure. No specific symptoms identified. No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. None identified. None identified.

Potential Effects of Acute Exposure

Potential Effects of Chronic Exposure Symptoms of Overexposure Carcinogenicity Other Effects Conditions Aggravated by Exposure

Section 12 Ecological Information
Ecotoxicity Biodegradability Mobility No information available. No information available. No information available.

Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information. Sodium azide preservative may form explosive compounds in metal drain lines. See NIOSH Bulletin: Explosive Azide Hazard (8/16/76).

Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IATA, US DOT, European ADR or Canadian TDG.

Section 15 Regulatory Information
US Federal and State Regulations SARA 313 CERCLA RG’s, 40 CFR 302.4 California Proposition 65 Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA. Edetic Acid is listed. Sodium Azide is listed. No ingredients listed

TROPONIN I TROPONIN I (Compartment R1a)

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Section 15 Regulatory Information (Continued)
US Federal and State Regulations Massachusetts MSL New Jersey Dept. of Health RTK List Pennsylvania RTK EU Dangerous Ingredients Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Ingredients on Ingredient Disclosure List: Ingredients with unknown toxicological properties: Not applicable Sodium Azide None None Edetic Acid is listed. Sodium Azide is listed. Edetic Acid is listed. Sodium Azide is listed. Edetic Acid is listed. Sodium Azide is listed.

Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A.

Page 7 of 27

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Beckman Coulter
TM

MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification

Product Name

TROPONIN I (Compartment R1b)
Component of P/N 33320 ACCESS® Manufactured for Beckman Coulter, Inc. Fullerton, CA 92834-3100, U.S.A.

TROPONIN I Doc. ID 33320-75 AA Issued (day/month/year) 09/12/1998

Part Number Series Name Manufacturer

Distributor and Emergency Phone No.

¤

Refer to attached list, Document ID: 472050, for local distributor and emergency phone numbers.

Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None

Section 3 Hazards Identification
Emergency Overview Colorless; Clear; Liquid; Mild odor Nonflammable aqueous solution. Does not meet EU, OSHA or WHMIS criteria for hazardous materials.

Physical Hazards Potential Health Effects Summary Product Hazard Classifications

No physical hazards were determined from a review of available literature. This product does not meet EU, OSHA OR WHMIS criteria for hazardous materials, however contact may result in skin or eye irritation. EU: Not applicable WHMIS: Exempt US OSHA: Not applicable

Section 4 First Aid Measures
Inhalation Eye Contact If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. If product is splashed in eyes, wash eyes under gently running water for 15 minutes or longer, making sure that the eyelids are held open. Obtain medical attention. In case of skin contact, wash area with soap and water. Rinse well with water. If ingested, wash out mouth with water. Call a physician.

Skin Contact Ingestion

TROPONIN I TROPONIN I (Compartment R1b)

Doc. ID: 33320-75 AA

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Section 5 Fire Fighting Measures
Flash Point Flammable Limits Autoignition Temp. Extinguishing Media Special Fire and Explosion Hazards Hazardous Combustion Products Protective Equipment for Firefighters Not applicable Not applicable Not applicable Use extinguishing media suitable for surrounding fire. No special hazards determined. Due to the nature and volume of this product, the type and amount of combustion products are negligible. Self-contained breathing apparatus is recommended for firefighters.

Section 6 Accidential Release Measures
Personal Precautions Spill and Leak Procedures Environmental Precautions Avoid skin contact. Use good laboratory procedures. Wipe up material carefully and place in container suitable for disposal. Contain spill to prevent migration.

Section 7 Handling and Storage
Handling Precautions Recommended Storage Conditions Use good laboratory procedures; avoid eye and skin contact. Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling.

Section 8 Exposure Controls and Personal Protection
Exposure Limits US OSHA: ACGIH: DFG MAK: Engineering Controls Respiratory Protection None established None established None established Use in well ventilated area. Under normal conditions, the use of this product should not require respiratory protection. If overexposure should occur and ventilation is not adequate to maintain airborne concentrations at acceptable levels, the use of respiratory protection should be evaluated by a qualified professional. Safety glasses or chemical goggles should be worn to prevent eye contact. Impervious gloves should be worn to prevent skin contact.

Eye Protection Skin Protection

Section 9 Physical and Chemical Properties
Physical State Liquid

TROPONIN I TROPONIN I (Compartment R1b)

Doc. ID: 33320-75 AA

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Section 9 Physical and Chemical Properties (Continued)
Color Transparency Odor Odor Threshold pH Boiling Point Melting Point Specific Gravity Vapor Pressure Vapor Density Evaporation Rate Coefficient of Water/Oil Distribution Percent Volatiles Solubility Water Organic Miscible Not available Colorless Clear Mild odor Not applicable 13 Not available Not available 1.0 @20°C Not available Not available Not available Not available Not applicable

Section 10 Stability and Reactivity
Stability Hazardous Incompatibilities Hazardous Decomposition Products Conditions to Avoid Stable under normal temperatures and pressures. Strong acids Peroxides Metals and metallic compounds When stored as labeled, no known hazardous decomposition products are formed during the shelf-life of this product. Avoid contact with incompatible materials.

Section 11 Toxicological Information
Toxicity Data for Hazardous Ingredients Primary Routes of Exposure Potential Effects of Acute Exposure Potential Effects of Chronic Exposure Symptoms of Overexposure Not applicable The most likely routes of exposure are skin and eye contact and inhalation. This product is not considered hazardous by OSHA, EU or WHMIS criteria, however contact may result in mild eye or skin irritation and ingestion may cause disgestive tract irritation. None identified. No specific symptoms identified.

TROPONIN I TROPONIN I (Compartment R1b)

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Section 11 Toxicological Information (Continued)
Carcinogenicity Other Effects Conditions Aggravated by Exposure No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. None identified. None identified.

Section 12 Ecological Information
Ecotoxicity Biodegradability Mobility No information available. No information available. No information available.

Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information.

Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IATA, US DOT, European ADR or Canadian TDG.

Section 15 Regulatory Information
US Federal and State Regulations SARA 313 CERCLA RG’s, 40 CFR 302.4 California Proposition 65 Massachusetts MSL New Jersey Dept. of Health RTK List Pennsylvania RTK No ingredients listed Sodium Hydroxide is listed. No ingredients listed Sodium Hydroxide is listed. Sodium Hydroxide is listed. Sodium Hydroxide is listed.

EU Dangerous Ingredients None

TROPONIN I TROPONIN I (Compartment R1b)

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Section 15 Regulatory Information (Continued)
Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Ingredients on Ingredient Disclosure List: Ingredients with unknown toxicological properties: Not applicable Sodium Hydroxide None

Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A.

Page 12 of 27

@

Beckman Coulter
TM

MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification

Product Name

TROPONIN I (Compartment R1c)
Component of P/N 33320 ACCESS® Manufactured for Beckman Coulter, Inc. Fullerton, CA 92834-3100, U.S.A.

TROPONIN I Doc. ID 33320-75 AA Issued (day/month/year) 09/12/1998

Part Number Series Name Manufacturer

Distributor and Emergency Phone No.

¤

Refer to attached list, Document ID: 472050, for local distributor and emergency phone numbers.

Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None

Section 3 Hazards Identification
Emergency Overview Light yellow; Clear; Liquid; Mild odor Nonflammable aqueous solution. Does not meet EU, OSHA or WHMIS criteria for hazardous materials.

Physical Hazards Potential Health Effects Summary Product Hazard Classifications

No physical hazards were determined from a review of available literature. This product does not meet EU, OSHA OR WHMIS criteria for hazardous materials, however contact may result in skin or eye irritation. EU: Not applicable WHMIS: Exempt US OSHA: Not applicable

Section 4 First Aid Measures
Inhalation Eye Contact If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. If product is splashed in eyes, wash eyes under gently running water for 15 minutes or longer, making sure that the eyelids are held open. Obtain medical attention. In case of skin contact, wash area with soap and water. Rinse well with water. If ingested, wash out mouth with water. Call a physician.

Skin Contact Ingestion

TROPONIN I TROPONIN I (Compartment R1c)

Doc. ID: 33320-75 AA

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Section 5 Fire Fighting Measures
Flash Point Flammable Limits Autoignition Temp. Extinguishing Media Special Fire and Explosion Hazards Hazardous Combustion Products Protective Equipment for Firefighters Not applicable Not applicable Not applicable Use extinguishing media suitable for surrounding fire. No special hazards determined. Due to the nature and volume of this product, the type and amount of combustion products are negligible. Self-contained breathing apparatus is recommended for firefighters.

Section 6 Accidential Release Measures
Personal Precautions Spill and Leak Procedures Environmental Precautions Avoid skin contact. Use good laboratory procedures. Wipe up material carefully and place in container suitable for disposal. Contain spill to prevent migration.

Section 7 Handling and Storage
Handling Precautions Recommended Storage Conditions Use good laboratory procedures; avoid eye and skin contact. Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling.

Section 8 Exposure Controls and Personal Protection
Exposure Limits US OSHA: ACGIH: DFG MAK: Engineering Controls Respiratory Protection None established None established None established Use in well ventilated area. Under normal conditions, the use of this product should not require respiratory protection. If overexposure should occur and ventilation is not adequate to maintain airborne concentrations at acceptable levels, the use of respiratory protection should be evaluated by a qualified professional. Safety glasses or chemical goggles should be worn to prevent eye contact. Impervious gloves should be worn to prevent skin contact.

Eye Protection Skin Protection

Section 9 Physical and Chemical Properties
Physical State Liquid

TROPONIN I TROPONIN I (Compartment R1c)

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Section 9 Physical and Chemical Properties (Continued)
Color Transparency Odor Odor Threshold pH Boiling Point Melting Point Specific Gravity Vapor Pressure Vapor Density Evaporation Rate Coefficient of Water/Oil Distribution Percent Volatiles Solubility Water Organic Miscible Not available Light yellow Clear Mild odor Not applicable 2.6 Not available Not available 1.01 @20°C Not available Not available Not available Not available Not applicable

Section 10 Stability and Reactivity
Stability Hazardous Incompatibilities Hazardous Decomposition Products Conditions to Avoid Stable under normal temperatures and pressures. Strong bases Strong Oxidizers When stored as labeled, no known hazardous decomposition products are formed during the shelf-life of this product. Avoid contact with incompatible materials.

Section 11 Toxicological Information
Toxicity Data for Hazardous Ingredients Primary Routes of Exposure Potential Effects of Acute Exposure Potential Effects of Chronic Exposure Symptoms of Overexposure Carcinogenicity Not applicable The most likely routes of exposure are skin and eye contact and inhalation. This product is not considered hazardous by OSHA, EU or WHMIS criteria, however contact may result in mild eye or skin irritation and ingestion may cause disgestive tract irritation. None identified. No specific symptoms identified. No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I.

TROPONIN I TROPONIN I (Compartment R1c)

Doc. ID: 33320-75 AA

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Section 11 Toxicological Information (Continued)
Other Effects Conditions Aggravated by Exposure None identified. None identified.

Section 12 Ecological Information
Ecotoxicity Biodegradability Mobility No information available. No information available. No information available.

Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information.

Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IATA, US DOT, European ADR or Canadian TDG.

Section 15 Regulatory Information
US Federal and State Regulations SARA 313 CERCLA RG’s, 40 CFR 302.4 California Proposition 65 Massachusetts MSL New Jersey Dept. of Health RTK List Pennsylvania RTK EU Dangerous Ingredients None No ingredients listed No ingredients listed No ingredients listed No ingredients listed No ingredients listed No ingredients listed

Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Ingredients on Ingredient Disclosure List: Ingredients with unknown toxicological properties: Not applicable Succinic Acid None

TROPONIN I TROPONIN I (Compartment R1c)

Doc. ID: 33320-75 AA

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Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A.

Page 17 of 27

@

Beckman Coulter
TM

MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification

Product Name

TROPONIN I (Compartment R1d)
Component of P/N 33320 ACCESS® Manufactured for Beckman Coulter, Inc. Fullerton, CA 92834-3100, U.S.A.

TROPONIN I Doc. ID 33320-75 AA Issued (day/month/year) 09/12/1998

Part Number Series Name Manufacturer

Distributor and Emergency Phone No.

¤

Refer to attached list, Document ID: 472050, for local distributor and emergency phone numbers.

Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None

Section 3 Hazards Identification
Emergency Overview Colorless; Clear; Liquid; Odorless Nonflammable aqueous solution. Does not meet EU, OSHA or WHMIS criteria for hazardous materials. Contains material of animal origin.

Physical Hazards Potential Health Effects Summary Product Hazard Classifications

No physical hazards were determined from a review of available literature. This product does not meet EU, OSHA or WHMIS criteria for hazardous materials. However, it does contain material of animal origin and should be considered potentially infectious. EU: Not applicable WHMIS: Exempt US OSHA: Not applicable

Section 4 First Aid Measures
Inhalation Eye Contact If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. If product is splashed in eyes, wash eyes under gently running water for 15 minutes or longer, making sure that the eyelids are held open. Obtain medical attention.

TROPONIN I TROPONIN I (Compartment R1d)

Doc. ID: 33320-75 AA

Page 18 of 27

Section 4 First Aid Measures (Continued)
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. Then gently wash skin with soap and water; rinse well. If product contacted broken skin, soak the wound area with a 1:10 dilution of fresh household bleach for 10 minutes. Rinse with water to remove residual bleach. (Remove contaminated clothing and disinfect with a 1:10 dilution of fresh household bleach.) Obtain medical attention. If ingested, wash out mouth with water. Call a physician.

Ingestion

Section 5 Fire Fighting Measures
Flash Point Flammable Limits Autoignition Temp. Extinguishing Media Special Fire and Explosion Hazards Hazardous Combustion Products Protective Equipment for Firefighters Not applicable Not applicable Not applicable Use extinguishing media suitable for surrounding fire. No special hazards determined. Due to the nature and volume of this product, the type and amount of combustion products are negligible. Self-contained breathing apparatus is recommended for firefighters.

Section 6 Accidential Release Measures
Personal Precautions Spill and Leak Procedures Use universal precautions during clean up procedures. As a precautionary measure, treat spilled material with a 1:10 bleach/water solution. Absorb liquid and place in container suitable for disposal. Avoid generation of aerosols during clean up. Comply with applicable waste disposal regulations. Contain spill to prevent migration.

Environmental Precautions

Section 7 Handling and Storage
Handling Precautions Recommended Storage Conditions This product should be handled as though capable of transmitting infectious diseases. Universal precautions should be followed when using this product. Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling.

Section 8 Exposure Controls and Personal Protection
Exposure Limits US OSHA: ACGIH: DFG MAK: None established None established None established

TROPONIN I TROPONIN I (Compartment R1d)

Doc. ID: 33320-75 AA

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Section 8 Exposure Controls and Personal Protection (Continued)
Engineering Controls Respiratory Protection Use in well ventilated area. Under normal conditions, the use of this product should not require respiratory protection. If overexposure should occur and ventilation is not adequate to maintain airborne concentrations at acceptable levels, the use of respiratory protection should be evaluated by a qualified professional. Safety glasses or chemical goggles should be worn to prevent eye contact. Impervious gloves, such as latex or equivalent, should be worn to prevent skin contact.

Eye Protection Skin Protection

Section 9 Physical and Chemical Properties
Physical State Color Transparency Odor Odor Threshold pH Boiling Point Melting Point Specific Gravity Vapor Pressure Vapor Density Evaporation Rate Coefficient of Water/Oil Distribution Percent Volatiles Solubility Water Organic Miscible Not available Liquid Colorless Clear Odorless Not applicable 7.4 Not available Not available 1.01 @20°C Not available Not available Not available Not available Not applicable

Section 10 Stability and Reactivity
Stability Hazardous Incompatibilities Stable under normal temperatures and pressures. Metals and metallic compounds Sodium azide forms explosive compounds with heavy metals. Repeated contact of low concentrations of azide with lead and copper commonly found in plumbing drains may result in the build up of shock sensitive compounds. When stored as labeled, no known hazardous decomposition products are formed during the shelf-life of this product. Keep away from incompatible material.

Hazardous Decomposition Products Conditions to Avoid

TROPONIN I TROPONIN I (Compartment R1d)

Doc. ID: 33320-75 AA

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Section 11 Toxicological Information
Toxicity Data for Hazardous Ingredients Primary Routes of Exposure Not applicable Common routes of entry include inhalation, ingestion and eye/skin contact. Specific paths of concern for potentially infectious materials are skin puncture, contact with broken skin, contact with mucous membranes and inhalation of aerosolized material. This product contains material of animal origin and should be considered as potentially capable of transmitting infectious diseases. Effects are similar to those for acute exposure. No specific symptoms identified. No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. None identified. None identified.

Potential Effects of Acute Exposure Potential Effects of Chronic Exposure Symptoms of Overexposure Carcinogenicity Other Effects Conditions Aggravated by Exposure

Section 12 Ecological Information
Ecotoxicity Biodegradability Mobility No information available. No information available. No information available.

Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information. Sodium azide preservative may form explosive compounds in metal drain lines. See NIOSH Bulletin: Explosive Azide Hazard (8/16/76).

Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IATA, US DOT, European ADR or Canadian TDG.

Section 15 Regulatory Information
US Federal and State Regulations SARA 313 Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA. 2-(2-Butoxyethoxy)Ethanol is subject to reporting requirements of Section 313, Title III of SARA. Sodium Phosphate, Dibasic is listed. Sodium Azide is listed. 2-(2-Butoxyethoxy)Ethanol is listed.

CERCLA RG’s, 40 CFR 302.4

TROPONIN I TROPONIN I (Compartment R1d)

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Section 15 Regulatory Information (Continued)
US Federal and State Regulations California Proposition 65 Massachusetts MSL New Jersey Dept. of Health RTK List Pennsylvania RTK No ingredients listed Sodium Phosphate, Dibasic is listed. Sodium Azide is listed. Sodium Phosphate, Dibasic is listed. Sodium Azide is listed. Sodium Phosphate, Dibasic is listed. Sodium Azide is listed. 2-(2-Butoxyethoxy)Ethanol is listed. None

EU Dangerous Ingredients Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Ingredients on Ingredient Disclosure List: Ingredients with unknown toxicological properties: Not applicable 2-(2-Butoxyethoxy)Ethanol Sodium Azide None

Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A.

Page 22 of 27

@

Beckman Coulter
TM

MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification

Product Name

TROPONIN I (Compartment R1e)
Component of P/N 33320 ACCESS® Manufactured for Beckman Coulter, Inc. Fullerton, CA 92834-3100, U.S.A.

TROPONIN I Doc. ID 33320-75 AA Issued (day/month/year) 09/12/1998

Part Number Series Name Manufacturer

Distributor and Emergency Phone No.

¤

Refer to attached list, Document ID: 472050, for local distributor and emergency phone numbers.

Section 2 Composition and Information on Ingredients
Hazardous Ingredients: Chemical Name Glycerol CAS # 56-81-5 % by wt. <15 EU No Meets Hazardous Criteria: US OSHA Yes WHMIS Exempt

See Section 15 Regulatory Information for additional information on ingredient hazard classifications.

Section 3 Hazards Identification
Emergency Overview Colorless; Clear; Liquid; Odorless Nonflammable aqueous solution. Skin, eye and respiratory tract irritant. Contains animal material which may have come in contact with human material.

Physical Hazards Potential Health Effects Summary Product Hazard Classifications

No physical hazards were determined from a review of available literature. Exposure may result in irritation of skin, eyes, and mucous membranes. See Section 11 Toxicological Information for more detailed health information. EU: Not applicable WHMIS: Exempt US OSHA: Hazardous

Section 4 First Aid Measures
Inhalation Eye Contact If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. If product is splashed in eyes, wash eyes under gently running water for 15 minutes or longer, making sure that the eyelids are held open. Obtain medical attention.

TROPONIN I TROPONIN I (Compartment R1e)

Doc. ID: 33320-75 AA

Page 23 of 27

Section 4 First Aid Measures (Continued)
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. Then gently wash skin with soap and water; rinse well. If product contacted broken skin, soak the wound area with a 1:10 dilution of fresh household bleach for 10 minutes. Rinse with water to remove residual bleach. (Remove contaminated clothing and disinfect with a 1:10 dilution of fresh household bleach.) Obtain medical attention. If ingested, wash out mouth with water. Call a physician.

Ingestion

Section 5 Fire Fighting Measures
Flash Point Flammable Limits Autoignition Temp. Extinguishing Media Special Fire and Explosion Hazards Hazardous Combustion Products Protective Equipment for Firefighters Not applicable Not applicable Not applicable Use extinguishing media suitable for surrounding fire. No special hazards determined. Due to the composition and volume of this product, combustion products generated from it are not expected to present a significant hazard. Self-contained breathing apparatus is recommended for firefighters.

Section 6 Accidential Release Measures
Personal Precautions Spill and Leak Procedures Use universal precautions during clean up procedures. As a precautionary measure, treat spilled material with a 1:10 bleach/water solution. Absorb liquid and place in container suitable for disposal. Avoid generation of aerosols during clean up. Comply with applicable waste disposal regulations. Contain spill to prevent migration.

Environmental Precautions

Section 7 Handling and Storage
Handling Precautions Recommended Storage Conditions This product should be handled as though capable of transmitting infectious diseases. Universal precautions should be followed when using this product. Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling.

Section 8 Exposure Controls and Personal Protection
Exposure Limits US OSHA: Glycerol total dust: 10 mg/m3 TWA; respirable fraction: 5 mg/m3 TWA

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Section 8 Exposure Controls and Personal Protection (Continued)
ACGIH: Glycerol DFG MAK: Engineering Controls Respiratory Protection 10 mg/m3 TWA (total dust/particulate) None established Use in well ventilated area. Under normal conditions, the use of this product should not require respiratory protection. If overexposure should occur and ventilation is not adequate to maintain airborne concentrations at acceptable levels, the use of respiratory protection should be evaluated by a qualified professional. Safety glasses or chemical goggles should be worn to prevent eye contact. Impervious gloves, such as latex or equivalent, should be worn to prevent skin contact.

Eye Protection Skin Protection

Section 9 Physical and Chemical Properties
Physical State Color Transparency Odor Odor Threshold pH Boiling Point Melting Point Specific Gravity Vapor Pressure Vapor Density Evaporation Rate Coefficient of Water/Oil Distribution Percent Volatiles Solubility Water Organic Miscible Not available Liquid Colorless Clear Odorless Not applicable 7.0 Not available Not available 1.0 @20°C Not available Not available Not available Not available Not applicable

Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.

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Section 10 Stability and Reactivity (Continued)
Hazardous Incompatibilities Strong acids Strong bases Strong Oxidizers Peroxides Permanganates Metals and metallic compounds Sodium azide forms explosive compounds with heavy metals. Repeated contact of low concentrations of azide with lead and copper commonly found in plumbing drains may result in the build up of shock sensitive compounds. When stored as labeled, no known hazardous decomposition products are formed during the shelf-life of this product. Keep away from incompatible material.

Hazardous Decomposition Products Conditions to Avoid

Section 11 Toxicological Information
Toxicity Data for Hazardous Ingredients Glycerol Primary Routes of Exposure Inhalation LC50 Rat : >570 mg/m3/1H; Oral LD50 Rat : 12600 mg/kg; Oral LD50Mouse : 4090 mg/kg; Dermal LD50 Rabbit : >10 gm/kg Common routes of entry include inhalation, ingestion and eye/skin contact. Specific paths of concern for potentially infectious materials are skin puncture, contact with broken skin, contact with mucous membranes and inhalation of aerosolized material. Exposure to glycerol by inhalation of mists may cause respiratory tract irritation; skin or eye contact may cause irritation. Mildly toxic by ingestion. Symptoms may include headache, nausea and vomiting. Very high doses may cause kidney damage. This product contains materials of animal origin, some of which may have come into contact with human material during processing. The product should be considered as potentially capable of transmitting infectious diseases. Repeated or prolonged exposure to glycerol by skin contact may cause dermatitis with irritation and swelling. No specific symptoms identified. No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. Reproductive effects have been reported in animal studies. None identified.

Potential Effects of Acute Exposure

Potential Effects of Chronic Exposure Symptoms of Overexposure Carcinogenicity Other Effects Conditions Aggravated by Exposure

Section 12 Ecological Information
Ecotoxicity Biodegradability Mobility Toxic to fish and other water organisms. No information available. No information available.

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Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information. Sodium azide preservative may form explosive compounds in metal drain lines. See NIOSH Bulletin: Explosive Azide Hazard (8/16/76).

Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IATA, US DOT, European ADR or Canadian TDG.

Section 15 Regulatory Information
US Federal and State Regulations SARA 313 Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA. Zinc Chloride is subject to reporting requirements of Section 313, Title III of SARA. Zinc Chloride is listed. Sodium Azide is listed. No ingredients listed Glycerol is listed. Zinc Chloride is listed. Sodium Azide is listed. Magnesium Chloride is listed. Zinc Chloride is listed. Sodium Azide is listed. Magnesium Chloride is listed. Glycerol is listed. Zinc Chloride is listed. Sodium Azide is listed. Magnesium Chloride is listed.

CERCLA RG’s, 40 CFR 302.4 California Proposition 65 Massachusetts MSL

New Jersey Dept. of Health RTK List Pennsylvania RTK

EU Dangerous Ingredients None

Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Ingredients on Ingredient Disclosure List: Ingredients with unknown toxicological properties: Not applicable Zinc Chloride Sodium Azide None

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Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A.


								
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