Speaker: Rohit N. Kulkarni MD PhD Joslin Diabetes Center, Harvard Medical School Title: Insulin Signaling and beta-cell Proliferation Abstract: Evidence gathered by multiple laboratories over the last few years indicates that insulin/IGF-I signaling, while not being critical for early development of islet/-cell growth, is important for maintenance of adult -cell mass. Our laboratory has created and characterized several compound knockout mouse models to directly evaluate the role(s) of insulin and IGF-1 receptors in maintaining -cell mass, -cell replication and in the islet hyperplastic response to insulin resistance. Data on - cell-specific and pancreas-specific insulin and IGF-1 receptor double knockouts created using RIP- Cre or PDX-1-Cre respectively will be presented to demonstrate effects of functional loss of both insulin and IGF-1 receptors on early development of islets/-cells. Furthermore, experiments will be discussed regarding the critical role of insulin signaling for islet hyperplastic response to insulin resistance.
Pages to are hidden for
"Speaker: Rohit N"Please download to view full document