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					Page 1/5 Material Safety Data Sheet Date Printed 07/07/2000 1 Substance Identification · Product Name: PD 0302081-0000 · Synonyms: (S)-N>1-((2R,3S)-2-Ethoxy-5-oxo-tetrahydro-furan-3-yl)-2-isopropylN>4-(2-quinolin-5-yl-ethyl)-succinamide MSDS #: P499F00 · Process: PD 0302081 · Step: Final Product · Manufacturer/Supplier: Parke-Davis (Research) A division of the Warner-Lambert Company 2800 Plymouth Road Ann Arbor, MI 48105 USA · Further information available from: Parke-Davis Research (USA) 1-734-622-7000 · Additional Information: This Material Safety Data Sheet conforms to 91/155/EEC and 93/112/EEC. 2 Composition/Data on Ingredients · Chemical Characterization: CAS No. Description: (S)-N>1-((2R,3S)-2-Ethoxy-5-oxo-tetrahydro-furan-3-yl)-2isopropyl-N>4-(2-quinolin-5-yl-ethyl)-succinamide 3 Hazards Identification · Hazard Description: Toxicological and/or chemical properties have not been thoroughly investigated. · W-L Occupational Hazard Labels: Experimental Pharmaceutical · W-L Health Hazard Class: 3 - Moderate to High Hazard · Classification System: The information in this data sheet is consistent with current EU regulations and has been expanded by internal Warner-Lambert labeling. · Additional Information: If you do not understand the hazards or safety precautions described in this data sheet, contact your supervisor or safety administrator before handling this material. Refer to Section 11 for more information on the toxicological properties of this material. USA Reviewed on 07/07/2000

Page 2/5 Material Safety Data Sheet Date Printed 07/07/2000 Product Name: PD 0302081-0000 4 First Aid Measures · General Information: Rescue personnel must wear appropriate protective equipment during removal of victims from contaminated areas. · Eye Contact: In case of accidental contact, immediately flush eyes with water. Hold eyelids open to ensure adequate flushing. Get immediate medical assistance. · Skin Contact: In case of accidental contact, immediately remove contaminated clothing and wash affected area with soap and water. Get immediate medical assistance. · Ingestion: In case of accidental ingestion, administer 1-2 glasses of milk or water to dilute ingested material. Get immediate medical assistance. · Inhalation: Remove victim to fresh air. Administer oxygen if breathing is difficult. Administer artificial respiration if breathing has stopped. Get immediate medical assistance. 5 Fire Fighting Measures · Suitable Extinguishing Agents: CO2, extinguishing powder or water spray. · Fire Hazards: In case of fire, the following can be released: Carbon monoxide (CO) Nitrogen oxides (NOx) High concentrations of airborne dust may form combustible mixtures. · Protective Equipment: Wear appropriate protective equipment, including self contained breathing apparatus (SCBA), during all fire fighting activities. 6 Accidental Release Measures · Health and Safety Precautions: In case of a large accidental release of this material, contact your supervisor, safety administrator, or emergency response team immediately. Avoid inhalation and direct contact. Wear appropriate personal protective equipment during all clean-up activities. Restrict access to keep out unauthorized or unprotected personnel. · Measures for Environmental Protection: Keep out of sewage systems and waterways. (Contd. on page 3) USA Reviewed on 07/07/2000

Page 3/5 Material Safety Data Sheet Date Printed 07/07/2000 Product Name: PD 0302081-0000 (Contd. of page 2) · Measures for Cleaning/Collecting: Confine the spill and remove incompatible materials and ignition sources. Secure the source of the release if conditions are safe. Collect spilled material by a method that controls dust generation such as a wet wipe and/or high efficiency particulate (HEPA) vacuum. Do not dry sweep. Place waste in an appropriate container for disposal. Properly decontaminate all protective equipment, tools, and work areas. 7 Handling and Storage · Handling: This material is for research purposes only and must be handled by technically qualified persons. Avoid dust generation. Handle in areas with adequate ventilation. Have emergency equipment for fires and spills readily available. Consult your supervisor or safety officer for additional information on handling procedures associated with specific operations. · Storage: Store in a cool, dry area. 8 Exposure Controls and Personal Protection · Engineering Controls: Local exhaust ventilation. Check ventilation for proper operation before starting work. Consult your supervisor or safety officer for additional information on engineering control as associated with specific operations. · Personal Protective Equipment: The personal protective equipment listed below is the minimum protection recommended for operations that produce significant amounts of dust, mist, or vapor or that have a potential for skin or mucous membrane contact. Consult your supervisor or safety officer if additional information on personal protective equipment associated with specific operations is needed. · General Protective and Hygienic Measures: Wash hands before breaks and at the end of work. Do not eat or drink while working with this material. Follow all safety precautions, posted signs, and warnings. If you do not understand the hazards or safety precautions described in this data sheet, contact your supervisor or safety administrator before handling this material. · Respiratory Protection: Full-hood powered air-purifying respirator (PAPR). Check respirator airflow when donning and before entering work area. Protection provided by air purifying respirators is limited. Wear a supplied air respirator if there is a potential for uncontrolled (Contd. on page 4) USA Reviewed on 07/07/2000

Page 4/5 Material Safety Data Sheet Date Printed 07/07/2000 Product Name: PD 0302081-0000 (Contd. of page 3) release, exposure levels are not known, or in other circumstances where air-purifying respirators may not provide adequate protection. · Hand Protection: Appropriate chemical resistant gloves Tape gloves to coveralls or suit. · Eye/Face Protection: For operations where eye/face protection is not provided by respiratory protection, wear safety glasses with side shields or splash goggles. · Body Protection: Coveralls Tape boots to coveralls or suit. Disposable booties · Additional Information: Inspect all protective equipment for defects before use. Properly decontaminate all protective equipment, tools, and work areas. 9 Physical and Chemical Properties · Form: Granulate Powder · Color: White Off-white · · Flash Point: · Solubility: · Water: · Organic Solvents: 10 Stability and Reactivity · Stability: No Data Available · Dangerous Reactions: Unstable in acid · Hazardous Decomposition Products: No dangerous decomposition products known 11 Toxicological Information Additional Information: There are no data available on the toxicological properties of this material. Toxicological properties have not been thoroughly investigated. 12 Ecological Information · General Notes: No Data Available USA Reviewed on 07/07/2000

Value/Range Not Applicable

Unit

Method

No Data Available No Data Available

Page 5/5 Material Safety Data Sheet Date Printed 07/07/2000 Product Name: PD 0302081-0000 13 Disposal Considerations · Disposal: Dispose of waste in accordance with all applicable laws and regulations. 14 Transport Information · Additional Information: This material is not regulated for transportation. 15 Regulatory Information · United States Regulations: · OSHA Hazard Communication Labels: Experimental Pharmaceutical · Additional Information: There are limited data available on this material. The regulatory status will be updated when additional information becomes available. 16 Other Information · Department issuing MSDS: Corporate Safety and Industrial Hygiene · Contact: Tracy A. Kimmel, Ph.D., DABT +1-973-385-2000 · Disclaimer: The information included in this data sheet is based on currently available scientific information and is accurate and reliable to the best of our knowledge. Warner-Lambert makes no other warranties, expressed or implied, and assumes no responsibility or liability for injury or damage caused by the material if reasonable safety procedures are not followed as specified in this data sheet. USA Reviewed on 07/07/2000


				
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