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							Material Safety Data Sheet
Synanthic
WW MSDS No.
320023

Section 1. Product and Company Identification
Manufactured/ Supplied by

Fort Dodge Animal Health 800 5th Street NW P.O. Box 518 Fort Dodge, IA 50501 Phone: 515-955-4600 Fax: 515-955-9149
Synanthic

Date of Preparation

11 June 2004

Product No.

320023

Product Trade Name Common Name Synonyms Chemical Formula Chemical Family Material Uses Packaging Formula Type

Formula No.
Synanthic (oxfendazole) Rumen Injection 22.5% None. NA Veterinary pharmaceutical. Anthelmintics. Pharmaceutical industry: Veterinary Pharmaceutical

Not available. Mixture. Not applicable. Not applicable.

CAS No. U.N. No. EINECS No. In Case of Emergency

515-955-6033

Liquid.

Section 2. Composition - Information on Ingredients
Name of Ingredients
1) Oxfendazole 2) Polyethylene Glycol (PEG 8000) 3) Water for Injection 4) Excipients - Inert ingredients considered non-hazardous

CAS No.
53716-50-0 25322-68-3 7732-18-5 Various

Conc.
22.5% <5% >70% Balance

EU Symbol
Xn Not controlled Not controlled Not controlled.

R Phrase
R20/21/22 Not controlled Not controlled Not controlled.

Section 3. Hazards Identification - Summary of Primary Effects and Critical Hazards
Acute Health Effects
Significant adverse health effects are associated with chronic high level exposures. Adverse health effects are considered unlikely when the product is administered according to label directions. Adverse effects may include abdominal cramps/pain. Possible teratogen (Pregnancy Category C) Adverse health effects are considered unlikely when the product is administered according to label directions. Excessive chronic exposure may affect the liver, gastrointestinal tract, testes, and blood. Biodegradable Keep out of waterways.

Chronic Health Effects

Environmental Hazards

Section 4. First Aid Measures - (by medical responders using "Universal Precautions")
Eye Contact
Contact with eyes may cause irritation. Flush eyes with plenty of water for 15 minutes, occasionally lifting upper and lower eyelids. (Check person for contact lenses and remove if present.) If redness or irritation persists have eyes examined by doctor immediately. Flush skin with plenty of soap and water for at least 15 minutes (remove all contaminated clothing and shoes). Get medical attention if symptoms persist. No specific treatment, treat symptomaticaly. If breathing is difficult give oxygen, if respiratory arrest occurs provide artificial respiration and seek immediate medical assistance. Inhalation of product is unlikely due to liquid state.

Skin Contact Inhalation

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Synanthic
Ingestion Notes to Medical Doctor

Page Number: 2 of 5 No specific treatment, treat symptomatically. Call medical doctor or poison control center immediately if large quantities are ingested. If ingested, seek medical advice immediately and show the container or the label. Direct treatment at control of symptoms.

Section 5. Fire-Fighting Measures
Extinguishing Media and Instructions Special Exposure Hazards Special Fire Fighting Protective Equipment
Follow your company's procedures. Use an extinguishing agent suitable for the surrounding class of fire. Use as little water as possible. Nonflammable, but will degrade on prolonged exposure to flame or high temperature. Avoid breathing vapors of this product. Avoid contact of spilled material and runoff with soil and surface waterways. Collect contaminated fire fighting water and prevent entry into drains and waterways. Qualified persons wearing full fire-fighting suits and approved/certified self-contained breathing apparatus.

Section 6. Accidental Release Measures
Small Spill Guidelines Large Spill Guidelines
Absorb with an inert material and place in an appropriate waste disposal container. Initiate company's spill response procedures immediately. Keep people out of area. Put on appropriate personal protective equipment (see Section 8). Dike spill area and do not allow product to reach sewage system and surface or ground water. Provide notification of any reportable spill to authorities. (See Section 12 for environmental risks and 13 for disposal information.) Absorb spill material with inert material (e.g., dry sand or earth), then place in a chemical waste container. Keep out of waterways.

Environmental Precautions

Section 7. Handling and Storage
Handling (ventilation and fire prevention) Storage (conditions and limitations)
Avoid contact with eyes, skin, and clothing. Wash after handling. Store tightly closed in original container. Keep containers in a well ventilated, secure location. S02- Keep out of the reach of children

Section 8. Exposure Controls and Personal Protection - (normal and intended use)
Exposure Guidelines Component REG. Limit OSHA (PEL) ACGIH (TLV®) Company Guideline

1) Oxfendazole
Engineering Design and Control Measures Protective Clothing Eyes Skin Hands Respiratory

TWA:

0.06 mg/m3 Wyeth Corporation

General ventilation is typically sufficient to keep airborne levels below established values. Provide eye wash and quick drench shower close to work station.

Safety glasses, goggles or face shield where product aerosol or splash potential exists. Lab coat or overalls. Gloves, Chemical resistant. Respirator selection must be based on anticipated exposure levels, product hazards, and the safe working limits of the selected respirator. A respirator is not needed under normal and intended conditions of product use.

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Synanthic Section 9. Physical and Chemical Properties
Physical State and Appearance Molecular Weight Boiling Point Melting/Freezing Point Density/Bulk Density Vapor Pressure Vapor Density Viscosity Partition Coefficient Solubility Flash Point Autoignition Point Explosion Limits Dust Explosivity
Liquid. (suspension) Mixture. Not available. Not available 1.08 - 1.10 (Water = 1) Nil Not available Not available log Kow=1.95 (oxfendazole) Easily soluble in cold water, hot water. Not applicable Not applicable Not applicable Not applicable.

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Odor Color pH

None White to off-white 4.6

Section 10. Stability and Reactivity
Conditions to Avoid and Incompatibility Decomposition Products
The product is stable. These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).

Section 11. Toxicological Information
Acute Effects Component Test Result Route Species

1) Oxfendazole
Eye Contact Skin Contact Inhalation Ingestion Chronic Effects Target Organs Adverse Effects Statements Sensitization

LD50 LD50

>6400 mg/kg >6400 mg/kg

oral dermal

Rat mouse

Practically non-irritating to eyes. Practically non-irritating to the skin. Not available. Due to paste form of product, inhalation is unlikely. Harmful if swallowed.

Potential organ systems affected by chronic overexposure are: Liver, testes, Gastrointestinal Tract, blood Adverse health effects are associated with chronic high level exposures. Adverse health effects are considered unlikely when the product is administered according to label directions. Adverse effects could include abdominal cramps/pain, central nervous system depression. Not known to be a skin sensitizer.

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Synanthic
Carcinogenic Effects Not classified or listed by IARC, NTP, OSHA, EU and ACGIH. Mutagenic Effects Teratogenic Effects
Not considered to be mutagenic.

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Possible teratogen - Pregnancy Class C classification based on tests showing teratogenic effects (fetotoxicity) in animals.

Reproductive Effects Severe chronic overexposure may affect the testes. Other Effects
None.

Section 12. Ecological Information
Environmental Fate Environmental Hazards Ecotoxicity Component Species Period Result
Readily biodegradable in the environment. Biodegradable Keep out of waterways.

1) Oxfendazole

96 hour LC50 >2.7 mg/L 96 hour LC50 >2.5 mg/L 48 hr EC50 0.52 mg/L
Not available.

Bluegill Sunfis Rainbow Trout Daphia magna

Other

Section 13. Disposal Considerations
Waste Handling and Disposal
Avoid disposal, make attempts to use product completely in accordance with intended use. Incinerate in a licensed high temperturatre hazardous waste incinerator.

Note: The waste generator must be informed of and follow all applicable rules and regulations for the handling and disposal of waste.

Section 14. Transport Information
Proper Shipping Name, Primary Class, UNNA Number, Pakaging Group ADR/RID Classification (Road and Rail Transport) ADNR Classification (Inland Waterways) IMO/IMDG Class (Maritime Transport) ICAO/IATA (Air Transport) CEFIC Tremcard U.S.A. DOT Class
Not controlled.

Not controlled.

Not controlled. Not controlled. Not controlled. Not available. Not controlled. Not available.
Flammability

HI Kemler

NFPA
Health

1 1 0

Reactivity Specific hazard

RQ

Not applicable.

Packaging Intructions

Not available.

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Synanthic Section 15. Regulatory Information and Warning Labels
(R) Risk Phrases

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R20/21/22- Harmful by inhalation, in contact with skin and if swallowed.

[N] Very toxic to aquatic organisms.

(S) Safety Phrases

S02- Keep out of the reach of children S25- Avoid contact with eyes

NOTE: This product has been classified in accordance with applicable country-specific regulations.

Section 16. Other Key Information
Other Considerations
11 June 2004

See product label and package insert for additional information.

Responsible for MSDS: FDAH Environmental, Health, and Safety Department

Fort Dodge Animal Health -- A Division of Wyeth Corporation
Notice to Reader * This symbol indicates information which has changed from the previous MSDS. The information provided in this MSDS is based on current knowledge, however, this does not constitute a warranty by the Company for that information. The product user is responsible for the appropriate and intended handling, use, and disposal of this product in accordance with label or package precautions and this information. All materials may present unknown hazards and should be used with caution.