Dyskinesia – Pipeline Review, H1 2012

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					                           Dyskinesia – Pipeline Review, H1 2012


                                                                                          Reference Code: GMDHC1859IDB
                                                                                             Publication Date: March 2012




Dyskinesia – Pipeline Review, H1 2012                                                       GMDHC1859IDB / Pub March 2012
© Global Markets Direct. This report is a licensed product and is not to be photocopied                           Page(1)
Dyskinesia – Pipeline Review, H1 2012




Table of Contents
Table of Contents ............................................................................................................................................................................... 2
    List of Tables ................................................................................................................................................................................. 5
    List of Figures ................................................................................................................................................................................ 6
Introduction......................................................................................................................................................................................... 7
    Global Markets Direct Report Coverage ........................................................................................................................................ 7
Dyskinesia Overview .......................................................................................................................................................................... 8
Therapeutics Development................................................................................................................................................................. 9
    An Overview of Pipeline Products for Dyskinesia .......................................................................................................................... 9
Dyskinesia Therapeutics under Development by Companies .......................................................................................................... 11
Dyskinesia Therapeutics under Investigation by Universities/Institutes............................................................................................ 13
Late Stage Products ......................................................................................................................................................................... 14
    Comparative Analysis .................................................................................................................................................................. 14
Mid Clinical Stage Products.............................................................................................................................................................. 15
    Comparative Analysis .................................................................................................................................................................. 15
Early Clinical Stage Products ........................................................................................................................................................... 16
    Comparative Analysis .................................................................................................................................................................. 16
Pre-Clinical Stage Products.............................................................................................................................................................. 17
    Comparative Analysis .................................................................................................................................................................. 17
Dyskinesia Therapeutics – Products under Development by Companies ........................................................................................ 18
Dyskinesia Therapeutics – Products under Investigation by Universities/Institutes.......................................................................... 19
Companies Involved in Dyskinesia Therapeutics Development ....................................................................................................... 20
    Merck & Co., Inc. ......................................................................................................................................................................... 20
    XenoPort, Inc. .............................................................................................................................................................................. 21
    Neurocrine Biosciences, Inc. ....................................................................................................................................................... 22
    Cubist Pharmaceuticals, Inc. ....................................................................................................................................................... 23
    Addex Pharmaceuticals ............................................................................................................................................................... 24
    Medicure Inc. ............................................................................................................................................................................... 25
    NeuroSearch A/S......................................................................................................................................................................... 26
    Neurim Pharmaceuticals (1991) Ltd. ........................................................................................................................................... 27
    Proximagen Neuroscience plc. .................................................................................................................................................... 28
    Santhera Pharmaceuticals Holding AG ....................................................................................................................................... 29
    EpiVax, Inc. ................................................................................................................................................................................. 30
    Adamas Pharmaceuticals, Inc. .................................................................................................................................................... 31
    QRxPharma Limited .................................................................................................................................................................... 32
    Neuraltus Pharmaceuticals, Inc. .................................................................................................................................................. 33
Dyskinesia – Therapeutics Assessment ........................................................................................................................................... 34
    Assessment by Monotherapy Products ....................................................................................................................................... 34
    Assessment by Combination Products ........................................................................................................................................ 35
    Assessment by Route of Administration ...................................................................................................................................... 36
    Assessment by Molecule Type .................................................................................................................................................... 38
Drug Profiles..................................................................................................................................................................................... 40
    Dipraglurant - Drug Profile ........................................................................................................................................................... 40



Dyskinesia – Pipeline Review, H1 2012                                                                                                           GMDHC1859IDB / Pub March 2012
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                                                                                   Page(2)
Dyskinesia – Pipeline Review, H1 2012




        Product Description................................................................................................................................................................. 40
        Mechanism of Action ............................................................................................................................................................... 40
        R&D Progress ......................................................................................................................................................................... 40
    NBI-98854 - Drug Profile ............................................................................................................................................................. 42
        Product Description................................................................................................................................................................. 42
        Mechanism of Action ............................................................................................................................................................... 42
        R&D Progress ......................................................................................................................................................................... 42
    Neu-120 - Drug Profile ................................................................................................................................................................. 43
        Product Description................................................................................................................................................................. 43
        Mechanism of Action ............................................................................................................................................................... 43
        R&D Progress ......................................................................................................................................................................... 43
    Tardoxal - Drug Profile ................................................................................................................................................................ 44
        Product Description................................................................................................................................................................. 44
        Mechanism of Action ............................................................................................................................................................... 44
        R&D Progress ......................................................................................................................................................................... 44
    Ordopidine - Drug Profile ............................................................................................................................................................. 45
        Product Description................................................................................................................................................................. 45
        Mechanism of Action ............................................................................................................................................................... 45
        R&D Progress ......................................................................................................................................................................... 45
    Naluzotan - Drug Profile .............................................................................................................................................................. 46
        Product Description................................................................................................................................................................. 46
        Mechanism of Action ............................................................................................................................................................... 46
        R&D Progress ......................................................................................................................................................................... 46
    Botulinum Toxin Type A - Drug Profile ........................................................................................................................................ 47
        Product Description................................................................................................................................................................. 47
        Mechanism of Action ............................................................................................................................................................... 47
        R&D Progress ......................................................................................................................................................................... 47
    Fipamezole - Drug Profile ............................................................................................................................................................ 48
        Product Description................................................................................................................................................................. 48
        Mechanism of Action ............................................................................................................................................................... 48
        R&D Progress ......................................................................................................................................................................... 48
    NP002 - Drug Profile ................................................................................................................................................................... 50
        Product Description................................................................................................................................................................. 50
        Mechanism of Action ............................................................................................................................................................... 50
        R&D Progress ......................................................................................................................................................................... 50
    Preladenant + Levodopa + Carbidopa - Drug Profile ................................................................................................................... 51
        Product Description................................................................................................................................................................. 51
        Mechanism of Action ............................................................................................................................................................... 51
        R&D Progress ......................................................................................................................................................................... 51
    Botox - Drug Profile ..................................................................................................................................................................... 52
        Product Description................................................................................................................................................................. 52
        Mechanism of Action ............................................................................................................................................................... 52
        R&D Progress ......................................................................................................................................................................... 52
    Amlodipine + Botulinum toxin - Drug Profile ................................................................................................................................ 53


Dyskinesia – Pipeline Review, H1 2012                                                                                                       GMDHC1859IDB / Pub March 2012
© Global Markets Direct. This report is a licensed product and is not to be photocopied                                                                                              Page(3)
Dyskinesia – Pipeline Review, H1 2012




        Product Description...................................................
				
DOCUMENT INFO
Description: Dyskinesia - Pipeline Review, H1 2012, provides an overview of the Dyskinesia therapeutic pipeline. This report provides information on the therapeutic development for Dyskinesia, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Dyskinesia. 'Dyskinesia - Pipeline Review, H1 2012' is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team.
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Global Markets Direct is a leading provider of global business intelligence and market analysis. It publishes a range of high quality company and market reports created by its large research and analysis capability and drawing from its extensive unique databases of industry-specific information. Global Markets Direct has a broad range of coverage over key market segments. It has a global scope, covering a broad range of countries constituting more than 90% of global revenues in each of the industries it covers. With a large dedicated research and analysis capability, Global Markets Direct employs rigorous primary and secondary research techniques in developing unique data sets and research materials. Its status as an independent research company allows Analysts to conduct trade interviews with key industry players. Access to unique databases of in-house market information further strengthens research and analysis capabilities. Materials are reviewed shaped by an expert panel of leading industry figures and representatives from key players in the relevant industries