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Adhesion molecules and lymphocyte homing

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					Adhesion molecules and
  lymphocyte homing
 成员:艾戈弋、鲍梦馨、车飞、陈超、
       董丽花、姜琳
review
Definition of adhesion molecules



   Cell adhesion molecules (CAMs) are cell
    surface proteins involved in the interaction
    of cell-cell or cell-extracellular matrix.
   CAMs take effect by the binding of receptor
    and ligand
              Classification

   Integrin family
   Selectin family
   Immunoglobulin (Ig) superfamily
   Cadherin family
   Mucin-like family
   Other adhesion molecules
Integrins
Selectin
ISF
Cadherin
      Lymphocyte homing



The directed migration of subsets of
circulating lymphocytes into particular
tissue sites.
               Classification

   Lymphoid stem cell migrate to central
    lymphoid organs
   Mature lymphocyte migrate to peripheral
    lymphoid organs
   Recirculation of lymphocytes
   Lymphocyte migrate to the sites of
    inflammation
   How adhesion
molecules participate
    in homing ?
Adhesion molecules mediate the
      process of homing
   Lymphocyte homing receptor (LHR)
    express on lymphocyte

   Addressin
    express on vascular endothelial cell
Adhesion Molecules on Lymphocyte
lymphocyte
  adhere,
 penetrate
  vascular
endothelial
    cell
      Adhesion molecules participate in
            lymphocyte homing
Lymphocyte homing receptor               Addressins

Adhesion Functions                       Adhesion     Functions
molecules                                molecules
L-selectin   Lymphocyte homing to        PNAd         Addressin of peripheral high
             peripheral immune organs                 venous endothelial cell


CLA          Receptor on memory T cell   E-selectin   Express on vascular
             surface for directionally                endothelial cell of
             homing to skin                           inflammation portion of skin

LFA-1        Participate in many         ICAM-1       Participate in many
             lymphocytes for homing      ICAM-2       lymphocytes for homing
       Adhesion molecules participate in
             lymphocyte homing
Lymphocyte homing receptor              Addressins

Adhesion Functions                      Adhesion     Functions
molecules                               molecules
VLA-4      Receptor of lymphocyte       VCAM-1 Express on vascular
           homing                              endothelial cell of
                                               inflammation portion

CD44       Participate in many          MAd          Intestinal lymphatic tissue and
           lymphocytes homing                        lamina propria

integrin   Receptor of lymphocyte for   MAd          Addressin of vascular
           directionally migrate to                  endothelial cell
           Peyre's Patch
α4β7
 Adhesion molecules in normal
condition in lymphocyte homing
     Pro-T cell migrate to thymus
   Homing receptor: CD44 and L-selectin
    expressed by pro-T cell
   Adressin: EA1 molecule expressed by thymus
    vascular endothelial cell

   And integrin α6β1、α6β4 play an important role
    in adhesion of pro-T cell
    Lymphocyte migrate to peripheral
          lymphoid organs
    Lymphocytes migrate to lymph node

   Homing receptor: L-selectin on lymphocyte
    Adressin:peripheral lymphonode vascular addressin
    (PNAd)

   LFA-1/ICAM-1、ICAM-2 and CD44/Mad
    molecules participate in the adhesion and penetration
    Lymphocyte migrate to peripheral
          lymphoid organs
    Lymphocyte migrate to Peyer’s Patch

   Homing receptor: integrin α4β7 molecule; CD44
    and LFA-1 molecules
   Adressin: Vascular endothelial cell of peyre’s patch
    specifically highly express mucosal vascular addressin
    (Mad); ICAM-1、ICAM-2

   Peyre’s patch means the aggregated lymphoid nodule in
    small intestine.
Lymphocyte homing
    Adhesion molecules in
    pathological condition
(inflammation) in lymphocyte
           homing
Function of adhesion molecules in
          inflammation
          Lymphocyte migrate to
           inflammation of skin

   Homing receptor: cutaneous lymphocyte-
    associated antigen (CLA);VLA-4;LFA-1

   Adressin: E-selectin ;VCAM-1; ICAM-
    1/ICAM-2
Lymphocyte migrate to
 inflammation of skin
         Lymphocyte migrate to
    inflammation of intestinal mucosa

   Molecule expressed by lymphocyte of intestinal
    mucous tissue called mucosal lymphocyte
    antigen (MLA)
          Lymphocyte migrate to
        inflammation of synovium

   Homing receptor: LFA-1 ; VLA-4 ; CD44

   Adressin: ICAM-1;VCAM-1;Mad
                    Disease

   Hyper-expressing adhesion molecules



   Hypo-expressing adhesion molecules
             However…
more mechanism needed to be explored…
Thank you

				
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