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Chloroform - Fisher - MSDS

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					                                                                                        SAFETY DATA SHEET



Chloroform, stabilized with amylene                                          Revision Date 26-Apr-2011
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                                                                               SAFETY DATA SHEET


Creation Date       20-Oct-2009                    Revision Date 26-Apr-2011                                Revision Number 2


                                  1. PRODUCT AND COMPANY IDENTIFICATION

Product Identifier
Product Description:                     Chloroform, stabilized with amylene
Cat No.                                  C/4960/25, C/4960/27, C/4960/17, C/4960/15, C/4960/08, C/4960/PB08, C/4960/PB15,
                                         C/4960/PB17, C/4960/21RSS, C/4960/24RSS, C/4960/25RSS, C/4960/34RSS,
                                         C/4960/27RSS
Synonyms                                 Methane trichloride; Methenyl trichloride; Formyl trichloride


Relevant identified uses of the substance or mixture and uses advised against
Recommended Use                       Laboratory chemicals
Uses advised against                  No Information available

Details of the supplier of the safety data sheet
Company
Fisher Scientific UK
Bishop Meadow Rd
Loughborough, Leicestershire, Great Britain
LE115RG
Tel: 01509 231166
E-mail address                          begel.sdsdesk@thermofisher.com

Emergency Telephone Number
Tel: 01509 231166 Chemtrec US: (800) 424-9300
Chemtrec EU: 001 (202) 483-7616

                                               2. HAZARDS IDENTIFICATION

Classification of the substance or mixture
REGULATION (EC) No 1272/2008
Acute oral toxicity                                                                       Category 4
Skin Corrosion / irritation                                                               Category 2
Carcinogenicity                                                                           Category 2
Specific target organ systemic toxicity (repeated exposure)                               Category 2


Classification according to EU Directives 67/548/EEC or 1999/45/EC
For the full text of the R phrases mentioned in this Section, see Section 16



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Chloroform, stabilized with amylene                                          Revision Date 26-Apr-2011
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                                              2. HAZARDS IDENTIFICATION
Symbol(s)                              Xn - Harmful
R -phrase(s)                           R22 - Harmful if swallowed
                                       R38 - Irritating to skin
                                       R40 - Limited evidence of a carcinogenic effect
Risk Combination Phrases               R48/20/22 - Harmful: danger of serious damage to health by prolonged exposure through
                                       inhalation and if swallowed


Label Elements




Signal Word                            Warning

Hazard Statements
H315 - Causes skin irritation
H351 - Suspected of causing cancer
H302 - Harmful if swallowed
H373 - May cause damage to organs through prolonged or repeated exposure


Precautionary Statements - EU (§28, 1272/2008)
P281 - Use personal protective equipment as required
P260 - Do not breathe dust/fume/gas/mist/vapors/spray
P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water


Other Hazards
Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting
Unconsciousness

                              3. COMPOSITION/INFORMATION ON INGREDIENTS

Component                            EC No.            Weight %       CAS-No     Classification     GHSCLAS           REACH Reg. No.
Chloroform                      200-663-8        >95              67-66-3       Xn; R22-48/20/22 Acute Tox. 4     -
67-66-3                                                                         Xi; R38          (H302)
                                                                                Carc.Cat.3; R40 Skin Irrit. 2
                                                                                                 (H315)
                                                                                                 Carc. 2 (H351)
                                                                                                 STOT RE 2
                                                                                                 (H373)




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                                                                                             SAFETY DATA SHEET



Chloroform, stabilized with amylene                                          Revision Date 26-Apr-2011
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For the full text of the R phrases mentioned in this Section, see Section 16



                                                 4. FIRST AID MEASURES

Description of first aid measures
Eye Contact                             Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain
                                        medical attention.

Skin Contact                            Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention.

Ingestion                               Do not induce vomiting. Call a physician or Poison Control Center immediately.

Inhalation                              Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation
                                        if victim ingested or inhaled the substance; induce artificial respiration with a respiratory
                                        medical device. Obtain medical attention.

Notes to Physician                      Treat symptomatically

                                               5. FIRE-FIGHTING MEASURES

Extinguishing media

Suitable Extinguishing Media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Extinguishing media which must not be used for safety reasons
No information available.

Special hazards arising from the substance or mixture

Thermal decomposition can lead to release of irritating gases and vapors

Advice for fire-fighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective
gear. Thermal decomposition can lead to release of irritating gases and vapors.

                                       6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

Ensure adequate ventilation. Use personal protective equipment.

Environmental precautions

Should not be released into the environment.




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Chloroform, stabilized with amylene                                          Revision Date 26-Apr-2011
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Methods and material for containment and cleaning up

Soak up with inert absorbent material. Keep in suitable and closed containers for disposal.

                                                7. HANDLING AND STORAGE

Precautions for Safe Handling

Wear personal protective equipment. Ensure adequate ventilation. Do not get in eyes, on skin, or on clothing. Avoid ingestion and
inhalation. Use only under a chemical fume hood.

Conditions for safe storage, including any incompatibilities

Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from direct sunlight.

Specific End Uses

                             8. EXPOSURE CONTROLS / PERSONAL PROTECTION

Control parameters

Exposure limits
Component                      European Union      The United Kingdom          France               Belgium              Spain
Chloroform                                             TWA: 2 ppm            VME: 2 ppm            TWA: 2 ppm             Skin
                                                     TWA: 9.9 mg/m3         VME: 10 mg/m3         TWA: 10 mg/m3      VLA-ED: 2 ppm
                                                       STEL: 6 ppm          VLCT: 50 ppm                            VLA-ED: 10 mg/m3
                                                    STEL: 29.7 mg/m3       VLCT: 250 mg/m3
                                                                                 Skin


Component                          Italy               Portugal            The Netherlands           Finland           Denmark
Chloroform                      TWA: 2 ppm            TWA: 10 ppm          STEL: 25 mg/m3          TWA: 2 ppm         TWA: 2 ppm
                               TWA: 10 mg/m3                                TWA: 5 mg/m3          TWA: 10 mg/m3      TWA: 10 mg/m3
                                   Skin                                                            STEL: 4 ppm           Skin
                                                                                                  STEL: 20 mg/m3
                                                                                                       Skin


Component                        Austria              Switzerland              Poland               Norway              Ireland
Chloroform                         Skin                   Skin               NDS: 8 mg/m3          TWA: 2 ppm         TWA: 2 ppm
                                MAK: 2 ppm            STEL: 1 ppm                                 TWA: 10 mg/m3      TWA: 9.8 mg/m3
                               MAK: 10 mg/m3         STEL: 5 mg/m3                                    Skin                Skin
                                                      MAK: 0.5 ppm
                                                     MAK: 2.5 mg/m3




Derived No Effect Level (DNEL)           No information available.
Predicted No Effect Concentration        No information available.
(PNEC)

Exposure controls




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Chloroform, stabilized with amylene                                          Revision Date 26-Apr-2011
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Engineering Measures                    Ensure that eyewash stations and safety showers are close to the workstation location Ensure
                                        adequate ventilation, especially in confined areas
Personal protective equipment
      Eye Protection                    Safety glasses with side-shields
      Hand Protection                   Protective gloves
      Skin and body protection          Wear appropriate protective gloves and clothing to prevent skin exposure
      Respiratory Protection            Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN
                                        149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits
                                        are exceeded or if irritation or other symptoms are experienced


Hygiene Measures                        Handle in accordance with good industrial hygiene and safety practice
Environmental exposure controls         No information available.

                                    9. PHYSICAL AND CHEMICAL PROPERTIES

Physical State                                                    Liquid
Appearance                                                        Colorless
odor                                                              aromatic
pH                                                                No information available.
Vapor Pressure                                                     213 mbar @ 20 °C
Vapor Density                                                      4.12 (Air = 1.0)
Viscosity                                                         0.56 mPa s at 20 °C
Boiling Point/Range                                               61 - 61°C / 141.8 - 142.7°F
Melting Point/Range                                               -63°C / -81.4°F
Flash Point                                                       No information available.
Autoignition Temperature                                          No information available.
Evaporation Rate                                                   (Butyl Acetate = 1.0)
Water Solubility                                                  8 g/L (20°C)
Specific Gravity                                                  1.480
Molecular Formula                                                 C H Cl3
Molecular Weight                                                  119.38

                                            10. STABILITY AND REACTIVITY

Reactivity

Chemical Stability

Stable under normal conditions. Sensitivity to light.

Possibility of Hazardous Reactions

Hazardous Polymerization                Hazardous polymerization does not occur.
Hazardous Reactions .                   None under normal processing..

Conditions to Avoid

Incompatible products, Excess heat, Exposure to light.




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                                                                                          SAFETY DATA SHEET



Chloroform, stabilized with amylene                                          Revision Date 26-Apr-2011
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Incompatible Materials

Strong oxidizing agents.

Hazardous Decomposition Products

Carbon monoxide (CO). Carbon dioxide (CO2). Hydrogen chloride gas. Phosgene. Chlorine.

                                       11. TOXICOLOGICAL INFORMATION

Information on Toxicological Effects


Acute Toxicity



Component Information

Component                                   LD50 Oral                      LD50 Dermal                      LC50 Inhalation
Chloroform                               695 mg/kg ( Rat )              3980 mg/kg ( Rabbit )            47,702 mg/L ( Rat ) 4 h




Chronic Toxicity

Carcinogenicity                        The table below indicates whether each agency has listed any ingredient as a carcinogen
Component                                                 IARC                                              UK
Chloroform                                               Group 2B




Sensitization                          No information available.
Mutagenic Effects                      No information available
Reproductive Effects                   No information available.
Developmental Effects                  No information available.
Target Organs                          Skin Respiratory system Eyes Liver Heart Kidney Central nervous system (CNS)
Other Adverse Effects                  See actual entry in RTECS for complete information
Endocrine Disruptor Information        None known



                                          12. ECOLOGICAL INFORMATION

Toxicity

Ecotoxicity effects
      Component             Freshwater Algae             Freshwater Fish               Microtox                  Water Flea


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                                                                                         SAFETY DATA SHEET



Chloroform, stabilized with amylene                                          Revision Date 26-Apr-2011
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       Chloroform           EC50 = 560 mg/L/48h 300 mg/L LC50 96 h            Photobacterium      EC50 = 28.9 mg/L/48h
                                                71 mg/L LC50 96 h             phosphoreum: EC50 =
                                                18 mg/L LC50 96 h             520 mg/L/5 min
                                                                              Photobacterium
                                                                              phosphoreum: EC50 =
                                                                              670 mg/L/15 min
                                                                              Photobacterium
                                                                              phosphoreum: EC50 =
                                                                              670 mg/L/30min



Persistence and degradability

No information available

Bioaccumulative potential

No information available.

Component                                                                                      log Pow
Chloroform                                                                                        2


Mobility in soil

No information available.

Results of PBT and vPvB assessment

Other adverse effects

No information available

                                        13. DISPOSAL CONSIDERATIONS

Waste treatment methods

Waste from Residues / Unused          Dispose of in accordance with local regulations
Products

Contaminated Packaging                Empty containers should be taken for local recycling, recovery or waste disposal

14. TRANSPORT INFORMATION

IMDG/IMO
      UN-No                           UN1888
      Hazard Class                    6.1
      Packing Group                   III



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Chloroform, stabilized with amylene                                          Revision Date 26-Apr-2011
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14. TRANSPORT INFORMATION
       Proper Shipping Name            Chloroform


ADR
       UN-No                           UN1888
       Hazard Class                    6.1
       Packing Group                   III
       Proper Shipping Name            Chloroform


IATA
       UN-No                           UN1888
       Hazard Class                    6.1
       Packing Group                   III
       Proper Shipping Name            Chloroform




                                         15. REGULATORY INFORMATION

Safety, health and environmental regulations/legislation specific for the substance or mixture
International Inventories

             Component        EINECS   ELINCS       NLP   TSCA   DSL   NDSL   PICCS   ENCS   CHINA   AICS   KECL
Chloroform                       -        -                 X     X      -      X       X      X       X     X


Legend

TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
EINECS/ELINCS - European Inventory Lists
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
PICCS - Philippines Inventory of Chemicals and Chemical Substances
ENCS - Japan Existing and New Chemical Substances
CHINA - China Inventory of Existing Chemical Substances
AICS - Inventory of Chemical Substances
KECL - Existing and Evaluated Chemical Substances


Chemical Safety Assessment

                                              16. OTHER INFORMATION




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Chloroform, stabilized with amylene                                          Revision Date 26-Apr-2011
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                                               16. OTHER INFORMATION
Text of R phrases mentioned in Section 2-3
R22 - Harmful if swallowed
R38 - Irritating to skin
R40 - Limited evidence of a carcinogenic effect
R48/20/22 - Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed


Revision Date                           26-Apr-2011
Revision Summary                        (M)SDS sections updated, 2, 16.
This safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006
Disclaimer
The information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date
of its publication. The information given is designed only as a guide for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered as a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
material or in any process, unless specified in the text.

                                                    End of Safety Data Sheet




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