Chronic Eosinophilic Pneumonia.ppt - plaza.ufl.edu plaza.ufl.edu by ert554898

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									Chronic Eosinophilic Pneumonia


  As Presented by Brett W. Baskovich…
                 What is it?
• Pneumonia
• Eosinophilic
• Chronic
Causes of Eosinophilic Pneumonia
• Churg-Strauss Syndrome
• Allergic Bronchopulmonary Aspergillosis
• Medications/Drugs/Toxins
  – Nitrofurantoin, ampicillin, ibuprofen, naproxen,
    phenytoin, sulfasalazine, tetracycline
• Parasites- Löffler's syndrome
                  Symptoms
•   Cough
•   Fever
•   Shortness of breath
•   Night sweats
•   Wheezing
•   Weight loss
                 Diagnosis
• Typically made 7 mo. after sx begin
• Bronchoalveolar lavage
                Treatment
• Option 1: Steroids
                 Treatment
• Prednisone 40 – 60 mg/day
  – Continue until Sx and CXR resolved (4-6 weeks)
  – Cut dose in half (8 weeks)
  – Reduce by 5 mg every 4 weeks
               Treatment
• Maintain patient on minimum possible dose
• Switch to alternate-day prednisone
• Add inhaled corticosteroids
                Treatment
• High-dose inhaled corticosteroid
  – Beclometasone dipropionate 1,600 mcg/day
                          References
• Chronic eosinophilic pneumonia complicated by bronchial asthma and
  diabetes mellitus successfully treated with suplatast tosilate and high-
  dose inhaled corticosteroid therapy. Fujimori K, Shimatsu Y et al. Nihon
  Kokyuki Gakkai Zasshi. 1999 Nov;37(11):903-8.
• Chronic eosinophilic pneumonia: treatment with inhaled corticosteroids.
  Minakuchi M, Niimi A et al. Respiration. 2003 Jul-Aug;70(4):362-6.
• Eosinophilic lung diseases: a clinical, radiologic, and pathologic overview.
  Jeong YJ, Kim KI et al. Radiographics. 2007 May-Jun;27(3):617-37;
  discussion 637-9.
• Chronic eosinophilic pneumonia. Edwards LT, Fulmer JM et al. BUMC
  Proceedings. 1999;12:67-74.
• Chronic eosinophilic pneumonia: a review. Alam M, Burki NK. South Med
  J. 2007 Jan;100(1):49-53.

								
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