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Skin Cells Converted To Beating Heart Cells Without Stem Cell Stage

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					Skin Cells Converted
To Beating Heart Cells
Without Stem Cell
Stage
     By Abraham Angulo
     Professor Sheng Ding
     On Sunday January 31, 2011
        The process of converting skin cells to beating heart cells by skipping the stem cell
stage was first realized successfully on Sunday January 31, 2011. The research was
realized by Professor Sheng Ding who was leading this study and research. This research
will advance the medical world greatly in many ways and help avoid some obstacles posed
by stem cells. Converting skins cells directly to beating heart cells is a process that was
first inspired by stem cells and basically it is the same outcome just a different procedure
from the same idea of developing pluripotent stem cells. Converting skin cells directly to
the cells where the body needs them has many medical applications, and could lead to
treating cells injured or destroyed by disease and damage, Parkinson’s, Alzheimers, and
heart disease. If this procedure is approved it can remove some dangers with stem cells
such as the possibility to develop a tumor.

        The advantage of this procedure is that the cells put back into your body are your
own just like pluripotent stem cells. Meaning your body will accept the converted stem cells
without any drugs or medical treatment to force your body to accept the converted cells.
The difference between this procedure and pluripotent stem cells are that converting skin
cells skips the stem cell stage and goes directly to the completed form of what cell is
needed. The main advantage of this procedure is that converting the cells skips all the
maintaining of the pluripotent stem cells and it is faster to convert the skin cells to the cells
required. This procedure is not better than changing skin cells to pluripotent stem cells
because it is the same procedure just enhanced. The way the procedure is done is by
taking the same original four genes and injecting the into the skin cell just like in the
pluripotent stem cells procedure. The difference is that in the pluripotent procedure the
genes are left active in the cell for weeks, but in the converting procedure the genes are
left inactive just after a couple of days way before the cells can turn into iPS cells. After
genes are turned off the scientist send a signal to the cells to turn into heart cells. Although
this procedure has made a major breakthrough it is still very recent and further studies are
required to see if the conversion can be done for other needs in cells besides heart
necessities. If accomplished going through the pluripotent procedure will become obsolete.
Converting skin cells

  This process is converting an adult cell to
   a completely new cell without the stem
   cell process.
  The process begins with and adult skin
   cell and injecting the four original genes
   from the iPS process.
 After inserting the four genes the scientist
  turn off the genes to be inactive just after a
  couple of days after being inserted.
 Then a signal is given to the cell to turn
  into the cell which is needed.
 This process is like making iPS cells, but
  without the long laborious process.
Pluripotent Stem Cell
Process
Advantages

  This process eliminates the long
   laborious process of converting skin cells
   to iPS cells.
  Don’t have to maintain the iPS cells.
  Directly treat illness.
Disadvantages

  This procedure hasn’t been developed
   perfectly.
  Can only been done to beating heart
   cells.
Future Possiblities

  Could lead to treating cells injured or
   destroyed by disease and damage,
   Parkinson’s, Alzheimers, and heart
   disease.
  When studies keep advancing this
   procedure can be used to treat any
   damage to the body.
THE FUTURE NOW
 Replace iPS cells.
 There is no need to create iPS cells if
  you can get the cells needed right away.

				
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