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									196. New-onset sleep apnea during
Francesca Facco1, David Ouyang2, Phyllis
Zee3, William Grobman1
  Northwestern University Feinberg School of
Medicine, Department of Obstetrics and
Gynecology, Chicago, IL, 2Northshore
University HealthSystem, Obstetrics and
Gynecology, Evanston, IL, 3Northwestern
University, Neurology, Chicago, IL
OBJECTIVE: Although the hormonal and
physiologic changes of pregnancy may increase
the risk of sleep apnea (SA), it remains
unknown to what extent women who do not
have SA develop it as pregnancy progresses.
The objective of this study was to characterize
the incidence of and risk factors for new-onset
SA during pregnancy among a population at
STUDY DESIGN: Pregnant women with
chronic hypertension, pre-gestational diabetes,
obesity, and/or a history of preeclampsia were
recruited to undergo a sleep evaluation with the
Watch-PAT100 (WP100), an ambulatory
device designed to diagnose SA. Participants
wore the device in early pregnancy (6-20
weeks) and again in the third trimester (≥28
weeks). SA was defined as an apnea-hyponea
index (AHI) of ≥5. Early-persistent SA was
defined as AHI of ≥ 5 in early and late
pregnancy. New-onset SA was defined as an
AHI of < 5 in early pregnancy, but ≥ 5 on re-
test in the third trimester. Characteristics of
women early- persistent SA and those with and
without new-onset SA were compared using
ANOVA, and χ square tests as appropriate.
RESULTS: 78 women had valid early and
third trimester WP100 studies. 19 women
(34%) had early-persistent SA. Only 2 women
who had SA in early pregnancy tested negative
in the third trimester. Of the 57 women who
tested negative for SA in early pregnancy, 13
(23%) developed new-onset SA. Characteristics
of women with early-persistent SA and those
with and without new-onset SA are presented in
the Table. Women with early-persistent SA had
a higher BMI and a higher incidence of chronic
hypertension. Demographic and clinical
characteristics of women with new onset SA
were similar to those who never developed SA.
CONCLUSION: New-onset SA occurs in over
20% of high-risk women who initially test
negative for SA in early pregnancy however,
these women appear to have different
characteristics than women with early-
persistent SA. The clinical significance of new-
onset SA in pregnancy is yet to be determined.
Larger studies are needed to better understand
the epidemiology of new-onset SA associated
with pregnancy.

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