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Report from the Biostatistics and Data Management Center

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					Report from the Biostatistics
            and
 Data Management Center
              Constantine Gatsonis, PhD
    ACRIN Biostatistics and Data Management Center
                   Brown University
                     Providence, RI


29 February 2012
Biostatistics and Data Management Center
BDMC 2008-2009: Highlights

 Major emphasis on developing and
  launching new studies:
     Cancer: 6681, 6682, 6683, 6684, 6685, 6686,
      6687, 6688, 6689, 6690, 6691
     Cardiovascular: 4005
 Analysis for primary and secondary papers
  and abstracts in several protocols:
     6652, 6654, 6657, 6660, 6661, 6664, 6665, 6666,
      6667, 6668, 6673, 6677, 6683

Biostatistics and Data Management Center
Themes of new studies

 Imaging-based biomarkers for predicting
  response to therapy and long term outcomes.
     Majority of new studies
 CAD evaluation.
 Accuracy in diagnosis and staging.
 Diagnostic test impact on outcomes.
     Significant methodologic and practical challenges


Biostatistics and Data Management Center
Predicting response

  Cu64-ATSM PET for cervical cancer (6682)
  FMISO in glioblastoma (6684)
  DCE-MRI, DSC-MRI in glioblastoma(6686)
  F-Fluoride PET in prostate cancer (6687)
  FLT PET in breast cancer (6688)
  FLT PET and DCE-MRI in glioblastoma (6689)
  Optimal imaging in breast cancer (6691)


  Biostatistics and Data Management Center
Accuracy: diagnosis and staging

 CAD for CT Colonography (6681)
 CAD for mammography (6683)
 PET/CT for head and neck cancer (6685)
 CDE-MRI and DCE-CT for HCC in liver transplant
  candidates (6690)




Biostatistics and Data Management Center
Impact on outcomes


 CT angiography in the emergency room:
  Randomized comparison to usual care (4005).
 Preoperative MRI for women with breast cancer:
  Randomized study of impact on surgical outcomes,
  recurrence, quality of life and cost. (in development)




 Biostatistics and Data Management Center
Analysis and publications

 Analysis for primary and secondary papers
  and abstracts in several protocols:
     6652, 6654, 6657, 6660, 6661, 6664, 6665, 6666,
      6667, 6668, 6673, 6677, 6683
     Solid presence at RSNA.
     Abstracts at ASCO and other conferences.
 Publications volume needs to increase.
     Paper writing needs more attention and energy.

Biostatistics and Data Management Center
Informatics and Data Management

     Needs identified (from last year’s
      presentation):
        • Fully electronic data management
        • Improved data entry capabilities
        • Automated system for tracking data queries.

     Progress update:
        • Finally close to making decisions on choice of
          new system.
        • Transition will be a significant undertaking.
Biostatistics and Data Management Center
It has been quite a ride!




Biostatistics and Data Management Center

				
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