Dr. Horst Hemmerle

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Dr. Horst Hemmerle Powered By Docstoc
					      Dr. Horst Hemmerle
Eli Lilly & Company
Director Lead Generation Technologies:


Responsible for:
Compound Collection Enrichment Strategy
Screening Strategies – Target families
DCRT Technologies /Automation
Chemoinformatics/Chemogenomics
                        Solving Complex Issues




                                                                                 integration and creation of knowledge
                                           Prostate Cancer
    Disease mechanism




                                                                                 Informatcis platforms allow
   Cellular mechanism                                             Angiogenesis
                                                     Apoptosis




                                          FAS                    VEGF
   Molecular mechanism
                                     compounds




Annotated chemical diversity


                                                             Targets


                               Analysis – Predictions - Simulations
                                         Library Deliverables
        MTS of selected cassettes for                                             • Hits/Leads/Back-up Scaffolds
          Drug Discovery efforts
                                                                                  • Validation Tools (Hits,Fragments)
              Selected sets for                                                   • Ligands to Explore Polypharm
         Target of Interest evaluation

                                                                                             Ideal Drug Properties
            Dynamic                                                                                         Kinases
             Library                                                                                    GPCRs




                                                                                                                   Structural Novelty
                                                            GRIP
                                           G-protein coupled Receptor Iteration Panel
compounds                         data
                                                                                                            NHRs



      Iterative Screen Panels
    Kinases        GPCRs
    NHRs           Ion Channels
    Proteases      Lipases
    Transporters




                           Active Compounds and Information

				
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