Request for Applications
WVCTSI Ohio State CCTS Collaboration Pilot Award
The Ohio State University (OSU) Center for Clinical and Translational Science (CCTS) and the West Virginia Clinical and
Translational Science Institute (WVCTSI) are now accepting applications for Pilot Project Funding. The purpose of this
funding is to encourage the formation of new interdisciplinary research teams between OSU and WVU addressing
integrated solutions for translational problems improving human health. Pilot funding opportunities foster
innovative new tools for clinical research, the expansion of translational research, and establishment of
new investigative partnerships. It is expected that through generation of preliminary data this funding will
facilitate researchers in acquiring extramural support for new and expanded research efforts focusing on functional
aspects of translating empirical evidence into community based interventions.
Each proposal should have a submitting PI at OSU (including Nationwide Children’s Hospital) or WVU and a
partnering PI from the other institution (OSU or WVU). Submit a single application to the organization of the
submitting PI (WVCTSI or OSU CCTS). Include components of the submitting PI as well as that of the partnering PI.
The application should address one overall hypothesis justifying why this work must be inter-institutional. Do not
submit the same proposal to both institutions.
The major criteria for funding are scientific merit of the project, significance of partnership (why could the whole
work not be done in anyone institution), clear clinical or translational relevance, and the likelihood that funding will
result in submission of an application for external funding. Other factors that will be evaluated include the
significance of the planned research, unique research resources, and expertise and productivity of the investigators.
One award is expected for $50,000 ($25,000 to each partnering PI) in direct costs over one year (no indirect costs
will be accepted). The award funds will not be released until proof of IRB/IACUC approval has been provided from
both institutions (if applicable).
Use of funds: Funding can be used to support any direct research expenditure appropriate to furthering the research
goals. Funding will not be awarded as bridge funding for ongoing projects, to purchase large equipment for use as a
core resource or to support administrative staff. In addition to financial support, statistical and study design support
is available at no charge as long as the applicant makes the request one month prior to the grant deadline;
investigators are encouraged to take advantage of this, and other OSU CCTS services, as a way to extend their
To request a free OSU CCTS biostatistics study design consultation for a Pilot Project application (at OSU), applicants
must submit a Request for CCTS Services at the earliest time possible to schedule an appointment.
Eligibility Information: All OSU, WVU, and Nationwide Children’s Hospital (NCH) faculty researchers interested in
clinical or translational science are welcome to apply. OSU applicants must be registered members of the CCTS.
Membership information can be found at http://ccts.osu.edu/membership.
Application Deadline: 5:00 pm March 15, 2011. Electronic copies of proposals and any questions should be
submitted to: firstname.lastname@example.org (OSU) or email@example.com (WVU).
A joint OSU CCTS/WVCTSI RFA review committee will review proposals and select awardees. Award decisions will be
made and funding available April 2011.
RFA released February 1, 2011_
Application deadline March 15, 2011___
Earliest funding start date April 2011______
a. Personnel*, laboratory supplies, core expenses, and clinical study expenses such as research beds, nursing or
bionutrition staff, routine laboratory measures.
b. Travel funds that are needed for study conduct (e.g., participant travel, travel to partner institution) are
allowed if essential.
c. Only equipment that is essential for the study, and is not otherwise available, may be requested. Large
equipment expenditures are discouraged.
*CCTS Pilot Grants will not cover the salary of faculty members or administrative personnel (salary support for
students, graduate students, clinical trainees, post-doctoral and clinical fellows will be permitted). However, each
application should include at least 8.3% of the investigator’s time to be spent on this project. This time should
be cost shared against the award.
OHIO STATE CCTS INFRASTRUCTURE SERVICES
Investigators are encouraged to make use of the extensive core resources of the OSU CCTS. These services include:
Consulting services to assist in planning and identifying biomedical informatics support
Biostatistics services to assist in study design and data analysis (OSU faculty - initial grant planning
consultation is strongly encouraged for application)
Technical help with IRB or IACUC submissions including consent documents and HIPAA forms, and access
to a Research Subject Advocate as needed
Nursing, bionutrition and laboratory services through the Clinical Research Center
Resource materials for developing community-based studies
The application must be submitted by the Submitting PI electronically to either Valerie DeGroff (OSU) or Holly
Legleiter (WVU) as a single Word or PDF document using the following guidelines:
A. FULL APPLICATION INSTRUCTIONS
1. Abstract and Cover Page(2 pages maximum)
a. Name and role of the Principal Investigator, Co‐Investigators and Mentor(s)
b. Institution, Department, College, contact information of all investigators
c. Title of proposal
d. Abstract: brief description (maximum 250 words) of the proposed project
2. Research proposal (8‐pages maximum; follow Format Specifications listed below).
Clearly identify which portions of the proposal will be conducted at Ohio State and which at WVU.
a. Specific Aims/Objectives
c. Background and Significance (include translational and collaborative aspects of the project)
d. Disease Focus and Functional Significance (250 words)
e. Preliminary Data (no more than 6-8 key illustrations desired)
f. Research Design & Methods (also include the approach to statistical analyses, power estimates, etc.)
g. Proposed timeline, milestones, and deliverables for completion of the project within the one-year
h. Plans for future grant submissions utilizing data from the project
i. Literature Cited (not included in total page count)
j. IRB/IACUC name and approval date, if applicable (not included in page count)
3. Project Budget and Budget Justification (2 page)
a. Use provided Budget Worksheet
b. OSU principal investigator: For this pilot award, you are required to code at least 8.3% of your time
and effort on this project as a cost share to the OSU CTSA grant.
4. Collaboration Plan (2 pages)
a. Coordination of effort and team relationship
b. Describe the proposed communication between organizations
c. List responsibilities of each team member
d. Justification for inter-institution research
5. Mentorship plan (1 page)
a. Early stage investigators are encouraged to include a mentorship team/plan
6. Biographical Sketches for PI and Key Personnel including Mentors (NIH style)
a. Use the most recent version of the NIH Biographical Sketch Format Page.
b. Include eRA Commons username
c. Biosketch for the project PI first.
7. Letters of Support from Deans, Chairs, and Mentors (maximum of 5)
FORMAT SPECIFICATIONS. All applications must adhere to the following guidelines:
a. Use Arial 11 points or larger
b. Type density, including characters and spaces, must be no more than 15 characters per inch.
c. Type may be no more than six lines per inch.
2. Page Margins
a. Use at least one‐half inch margins (top, bottom, left, and right) for all pages
3. Application Paging
a. The application must be single‐spaced.
b. Consecutively number pages in the Research Proposal.
4. Figures, Graphs, Diagrams, Charts, Tables, Figure Legends, and Footnotes
a. You may use a smaller type size but it must be in black ink, readily legible, and follow the font
b. Do not include figures or other materials that are not inserted directly into the body of the
application. Any separate pages will be counted as part of the 8 page limit.
5. Documents and file name
A single combined pdf or Word file is acceptable and should be named as follows: [PI last name, first name,
date of submission]
Upon submission of an application, you should expect a receipt acknowledgement for your proposal
within 24 hours.
IACUC/IRB approval letter is required prior to release of funds from both institutions.
A 6‐month progress report is required.
A final report describing project accomplishments must be submitted within 60 days of the project end
The OSU CCTS itself is evaluated by the NIH on its effectiveness in stimulating new research findings and
publications. The following support acknowledgement should be included on all publications that result
from CCTS support.
“The project described was supported by Award Number UL1RR025755 from the National Center for Research
Resources, funded by the Office of the Director, National Institutes of Health (OD) and supported by the NIH Roadmap
for Medical Research. The content is solely the responsibility of the authors and does not necessarily represent the
official views of the National Center for Research Resources or the National Institutes of Health.”
The OSU CCTS Pilot program is directed by Drs. Chandan K. Sen and John Sheridan. The WVCTSI program is
directed by James O’Donnell. Please direct all OSU CCTS questions to Valerie DeGroff 614-366-7367 and WVCTSI
questions to Holy Legleiter,.