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					Publications

a. Manuscripts

1. Trepanier LA, Peterson ME, Aucoin DP, Pharmacokinetics of methimazole in normal
   cats and cats with hyperthyroidism. Res Vet Sci 50:69-74, 1991.

2. Trepanier LA, Peterson ME, Aucoin DP, Pharmacokinetics of intravenous and oral
   methimazole following single and multiple dose administration in normal cats. J Vet
   Pharmacol Ther 14:367-373, 1991.

3. Trepanier LA, Babish JG, Pharmacokinetic properties of bromide in dogs after the
   intravenous and oral administration of single doses. Res Vet Sci 58: 248-251, 1995.

4. Trepanier LA, Babish JG, Effect of dietary chloride content on the elimination of
   bromide by dogs. Res Vet Sci 58: 252-255, 1995.

5. Trepanier LA, Use of bromide as an anticonvulsant for dogs with epilepsy. J Am Vet
   Med Assoc 207: 163-166, 1995.

6. Ray K, Trepanier LA, Acland GM, Aguirre GD, PCR/RFLP marker in the canine opsin
   gene. Animal Genetics 27: 293-294, 1996.

7. Ray K, Zeiss C, Acland GM, Trepanier LA, Aguirre GD, A highly polymorphic RFLP
   marker in the canine transducin α-1 subunit gene (GNAT1). Animal Genetics 27: 372-
   373, 1996.

8. Cribb AE, Lee BL, Trepanier LA, Spielberg SP, Adverse reactions to sulphonamide and
   sulphonamide-trimethoprim antimicrobials: clinical syndromes and pathogenesis.
   Adverse Drug Reactions and Toxicol Rev 15: 9-50, 1996.

9. Ball MA, Rebhun WC, Trepanier LA, Gaarder J, Schwark WS, Corneal concentrations
   and preliminary toxicological evaluation of an itraconazole/dimethyl sulphoxide
   ophthlamic ointment. J Vet Pharmacol Ther 20: 100-104, 1997.

10. Stokol T, Trepanier LA, Parry BW, Finnin BC. Pharmacokinetics of von Willebrand
    factor and factor VIII in canine von Willebrand disease and haemophilia A. Res Vet Sci
    63: 23-27, 1997.

11. Trepanier LA, Ray K, Winand N, Spielberg SP, Cribb AE, Cytosolic arylamine N-
    acetyltransferase deficiency in the dog and other canids due to an absence of NAT genes.
    Biochem Pharmacol 54: 73-80, 1997.
12. Zeiss CJ, Trepanier LA, Aguirre GD, Ray K, A highly conserved microsatellite in the 3'
    untranslated region of the dystrophin gene in diverse mammalian species Animal
    Genetics 29:224-227, 1998.

13. Trepanier LA, Cribb AE, Spielberg SP, Ray K, Deficiency of cytosolic arylamine N-
    acetylation in the domestic cat and wild felids caused by the presence of only a single
    NAT1-like gene. Pharmacogenetics, 8: 169-179, 1998.

14. Trepanier LA, Schwark WS, Van Schoick A, Carrillo J. Therapeutic serum drug
    concentrations in epileptic dogs treated with potassium bromide alone or in combination
    with other anticonvulsants: 122 cases (1992-1996). J Am Vet Med Assoc 213: 1449-
    1453, 1998.

15. Kantrowitz LB, Peterson ME, Trepanier LA, Melian C, Nichols R. Measurement of
    serum total thyroxine, total triiodothyronine, free thyroxine, and thyrotropin
    concentrations in epileptic dogs treated with anticonvulsants. J Am Vet Med Assoc 214:
    1804-1808, 1999.

16. Gookin JL, Trepanier LA, Bunch SE. Clinical hypothyroidism associated with
    trimethoprim-sulfadiazine administration in a dog. J Am Vet Med Assoc 214: 1028-1031,
    1999.

17. Trepanier LA. Delayed hypersensitivity reactions to sulfonamides: syndromes,
    pathogenesis, and management. Veterinary Dermatol 10: 241-248, 1999.

18. Moore KW, Trepanier LA, Lautzenhiser SJ, Fialkowski JP, Rosin E. Pharmacokinetics of
    ceftazidime in dogs following subcutaneous administration and continuous infusion and
    the association with in vitro susceptibility of Pseudomonas aeruginosa. Am J Vet Res
    61:1204-1208, 2000.

19. Levitski RE, Trepanier LA. Effect of timing of blood collection on serum phenobarbital
    concentrations in dogs with epilepsy. J Am Vet Med Assoc 217: 200-204, 2000.

20. Trepanier LA, Miller JL. NADH-dependent reduction of sulfamethoxazole
    hydroxylamine in dog and human liver microsomes. Xenobiotica 30: 1111-1121, 2000.

21. Miller JL, Trepanier LA. Inhibition by atovaquone of CYP2C9-mediated
    sulfamethoxazole hydroxylamine formation. Eur J Clin Pharmacol 58: 69-72, 2002.

22. Hoffman SB, Yoder AR, Trepanier LA. Bioavailability of transdermal methimazole in a
    pluronic lecithin organogel (PLO) in healthy cats. J Vet Pharmacol Ther 25: 189-193,
    2002.

23. Salavaggione OE, Kidd LB, Prondzinski JL, Szumlanski CL, Pankrantz SV, Wang L.
    Trepanier LA, Weinshilboum RM. Canine red blood cell thiopurine S-methyltransferase:
    companion animal pharmacogenetics. Pharmacogenetics 12: 713-724, 2002.
24. Trepanier LA, Hoffman SB, Kroll M, Rodan I, Challoner L. Evaluation of once daily vs.
    divided twice daily dosing of methimazole in cats with hyperthyroidism. J Am Vet Med
    Assoc 222: 954-958, 2003.

25. Trepanier LA, Danhof R, Toll J, Watrous D. Clinical findings in 40 dogs with
    hypersensitivity associated with potentiated sulfonamides. J Vet Intern Med 17: 647-652,
    2003.

26. Gibbon KJ, Cyborski JM, Guzinski MV, Viviano KR, Trepanier LA. Safety of EMLA
    (lidocaine/prilocaine) cream for the placement of jugular catheters in cats. J Vet
    Pharmacol Ther 26: 1-3, 2003.

27. Salavaggione OE, Yang C, Kidd LB, Thomae B, Pankrantz SV, Trepanier LA,
    Weinshilboum RM. Cat red blood cell thiopurine S-methyltransferase: companion animal
    pharmacogenetics. J Pharmacol Exp Ther 308: 617-26, 2004.

28. Kidd LB, Salavaggione OE, Szumlanski CL, Miller JL, Weinshilboum RM, Trepanier
    LA. Thiopurine methyltransferase activity in red blood cells of dogs. J Vet Intern Med
    18: 214-218, 2004.

29. Sartor LL, Bentjen SA, Trepanier LA, Mealey KL. Loperamide toxicity after therapeutic
    doses in a Collie with the MDR1 mutation associated with ivermectin sensitivity. J Vet
    Intern Med 18: 117-118, 2004.

30. Trepanier LA, Yoder AR, Bajad S, Beckwith MD, Bellehumeur JL, Graziano FM.
    Plasma ascorbate deficiency is associated with impaired reduction of sulfamethoxazole
    nitroso in HIV infection. J Acquir Immunodef Syndr 36: 1041-1050, 2004.

31. Trepanier LA. Idiosyncratic toxicity associated with potentiated sulfonamides in the dog.
    J Vet Pharmacol Ther 27: 129-138, 2004.

32. Sartor LL, Trepanier LA, Kroll MM, Rodan I, Challoner L. Efficacy and safety of
    transdermal methimazole in the treatment of cats with hyperthyroidism. J Vet Intern Med
    18: 651-655, 2004.

33. Kurian JR, Bajad S, Miller JL, Chin N, Trepanier LA. NADH cytochrome b5 reductase
    and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and
    amidoximes in humans. J Pharmacol Exp Ther 311:1171-8, 2004.

34. Smith LJ, Krugner-Higby L, Trepanier LA, Flaska DE, Joers V, Heath TD. Comparative
    sedative effects and serum pharmacokinetics of oxymorphone after subcutaneous
    administration of a standard or liposome-encapsulated formulation in dogs. J Vet
    Pharmacol Ther 27: 369-72, 2004.

35. Vasilopulos RJ, Mackin A, Lavergne SN, Trepanier LA. Nephrotic syndrome associated
    with the administration of sulfadimethoxine/ormetoprim in a Doberman Pinscher. J Small
    An Practice (in press).
36. Trepanier LA, Pasloske K. AAVPT position paper regarding the evaluation of scientific
    manuscripts that involve the administration of compounded drugs to animals. J Vet
    Pharmacol Ther. 2004 27:537.

37. Lavergne SN, Volkmann EM, Maki JE, Yoder AR, Trepanier LA. Evaluation of the
    clinical, immunologic, and biochemical effects of sulfamethoxazole-nitroso
    administration to dogs: a pilot study. Toxicology 208: 63-72, 2005.



b. Book Chapters

1. Trepanier LA, The use of antithyroid drugs in the medical management of feline
   hyperthyroidism. In: Nichols, CE (ed): Problems in Veterinary Medicine 2: 668-682,
   1990.

2. Trepanier LA, Elliott J, Good prescribing practice: avoiding adverse drug reactions. In:
   Gorman N (ed): Canine Medicine and Therapeutics., 4th edition. Blackwell Science Ltd.,
   U.K., 1998. pp. 3-23.

3. Trepanier LA. Transdermal therapeutics. In: August, J (ed): Consultations in Feline
   Medicine (in press).

4. Trepanier LA, Bajad SU, Kurian JR. Evaluation of the cytochrome b5 / cytochrome b5
   reductase pathway (Unit 4.18) Current Protocols in Toxicology (invited review, in press)



c. Research Proceedings and Abstracts

1. Trepanier LA, Peterson ME, Aucoin DP, Methimazole pharmacokinetics in the normal
    and hyperthyroid cat. Proc. of the 7th Annual Forum of the American College of
    Veterinary Internal Medicine (ACVIM), San Diego, p. 1037, 1989.

2.Trepanier LA, Pharmacokinetics and clinical use of bromide. Proc. of the 11th Annual
   Forum of the ACVIM, Washington, D.C., pp. 878-880, 1993.

3.Trepanier LA, Winand NJ, Ray K, Cribb AE, Spielberg SP. Molecular analysis of N-
   acetyltransferase genes in canids and felids. 11th International Symposium on
   Microsomes and Drug Oxidations (MDO), Los Angeles, CA, 1996.

4.Trepanier LA, Winand NJ, Ray K, Spielberg SP, Cribb AE. Evaluation of drug
   detoxification defects as possible risk factors for sulfonamide hypersensitivity in dogs.
   Proc. of the 15th Annual Forum of the ACVIM, Lake Buena Vista, FL, p. 684, 1997.

5.Trepanier LA. Optimal bromide therapy and monitoring. Proc. of the 15th Annual Forum of
   the ACVIM, Lake Buena Vista, FL, pp. 100-101, 1997.
6.Trepanier LA, Sulfonamide hypersensitivity in the dog. Proc. of the 16th Annual Forum of
   the ACVIM, San Diego, p. 466-468, 1998.

7.Trepanier LA, Ray K. Analysis of arylamine N-acetyltransferase sequences in carnivores:
   conservation of a single NAT1-like sequence and absence of NAT2. Proc. of the First
   International Workshop on Arylamine N-acetyltransferases, Queensland, Australia, p. 27,
   1998.

8.Trepanier LA, Miller JL. Low affinity NADH-dependent reduction of sulfamethoxazole
   hydroxylamine in dog liver microsomes. Proc. of the 9th North American Meeting of the
   International Society for the Study of Xenobiotics, Nashville, p.115, 1999.

9. Levitski RE, Lipsitz D, Trepanier LA. Evaluation of trough and peak serum
   phenobarbital levels in epileptic dogs. Proc. of the 17th Annual Forum of the ACVIM,
   Chicago, p. 703, 1999.

10. Trepanier LA. Using phenobarbital wisely: new data on optimal monitoring. Proc. of the
    17th Annual Forum of the ACVIM, Chicago, p. 268-270, 1999.

11. Danhof RS, Trepanier LA. Oxidation of sulfamethoxazole in normal dogs and dogs with
    sulfonamide hypersensitivity. Undergraduate Research Scholars Program, University of
    Wisconsin-Madison. May, 2000.

12. Miller JL, Trepanier LA. Atovaquone is a weak inhibitor in vitro of CYP2C9-mediated
    generation of sulfamethoxazole hydroxylamine. 13th International Symposium on
    Microsomes and Drug Oxidations (MDO), Stresa, Italy, 2000.

13. Yang C, Salavaggione E, Perez A, Wang L, Szumlanski C, Miller J, Kidd L, Trepanier
    LA, Weinshilboum R. Canine thiopurine methyltransferase (TPMT) pharmacogenetics:
    phenotype to genotype studies. Mayo Research Forum, Rochester MN, 2000.

14. Ladwig AK, Trepanier LA. Reduction of toxic nitroso drug metabolites as a marker for
    drug hypersensitivity. 10th Annual School of Veterinary Medicine Research and
    Recognition Day, Madison WI, April 2001.

15. Yoder AR, Trepanier LA. Pharmacokinetics of the topical form of methimazole in cats.
    Undergraduate Research Scholars Program, University of Wisconsin-Madison. May,
    2001.

16. Murayama K, Ladwig A, Yoder A, Trepanier LA. Plasma ascorbate deficiency correlates
    with impaired reduction of sulfamethoxazole nitroso in patients with HIV infection. 5th
    International Symposium on the Biological Oxidation of Nitrogen in Organic Molecules.
    Munich, Germany, 2001.

17. Miller JL, Murayama K, Dickerson EB, Huelsmeyer MK, Giles SS, Trepanier LA. Role
    of NADH cytochrome b5 reductase in sulfamethoxazole hydroxylamine reduction. 5th
    International Symposium on the Biological Oxidation of Nitrogen in Organic Molecules,
   and the 6th International Meeting of the Society for the Study of Xeniobiotic(ISSX).
   Munich, Germany, 2001.

18. Kidd LB, Trepanier LA, Szumlanski C, Perez A, Yang C, Weinshilboumm R. Variability
    in azathioprine metabolism in dogs. Proc. of the 19th Annual Forum of the ACVIM,
    Denver, p. 869, 2001.

19. Hoffman SB, Trepanier LA, Kroll M, Rodan I, Challoner L. Evaluation of dosing
    regimen in hyperthyroid cats treated with methimazole. Proc. of the 19th Annual Forum
    of the ACVIM, Denver, p. 864, 2001.

20. Trepanier LA. Update on methimazole: oral vs. transdermal, once vs. twice daily. Proc.
    of the 19th Annual Forum of the ACVIM, Denver, p. 550-552, 2001.

21. Danhof RS, Trepanier LA, Cribb AE, Toll J. Immunological findings in 45 dogs with
    sulfonamide-associated hypersensitivity. Undergraduate Symposium, University of
    Wisconsin-Madison. April, 2002.

22. Hoffman SB, Yoder AR, Trepanier LA. Bioavailability of transdermal methimazole in a
    pluronic lecithin organogel (PLO) in healthy cats. Proc. of the 20th Annual Forum of the
    ACVIM, Dallas, p. 793, 2002.

23. Trepanier LA. Transdermal formulations: which ones are effective? Proc. of the 20th
    Annual Forum of the ACVIM, Dallas, pp. 463-464, 2002.

24. Trepanier LA, Cribb AE, Danhof RS, Toll J. Clinical and immunologic findings in 45
    dogs with sulfonamide-associated hypersensitivity. Proc. of the 20th Annual Forum of the
    ACVIM, Dallas, p. 797, 2002.

25. Trepanier LA. Mechanisms of drug-associated hepatotoxicity in the dog and cat. Proc.of
    the 20th Annual Forum of the ACVIM, Dallas, pp. 669-671, 2002.

26. Price JE, Weinshilboum R, McGee R, Adjei A, Wood T, Salavaggione E. Kidd L,
    Trepanier LA. Canine catechol O-methyltransferase (COMT) companion animal
    pharmacogenetics: phenotype-to-genotype. Annual Biomedical Research Conference for
    Minority Students, New Orleans, November 2002.

27. Gibbon KJ, Cyborski J, Guzinski M, Trepanier LA. Safety of EMLA (lidocaine /
    prilocaine) analgesic cream for placement of jugular catheters in cats. Proc. of the 21st
    Annual Forum of the ACVIM, Charlotte, abstr. 119 (electronic proceedings), 2003.

28. Sartor LL, Trepanier LA, Kroll M, Rodan I, Challoner L. Clinical efficacy of transdermal
    methimazole in cats with hyperthyroidism. Proc. of the 21st Annual Forum of the
    ACVIM, Charlotte, abstr. 58, 2003.

29. Chin NA, Bajad S, Trepanier LA. Benzamidoxime reduction by cDNA-expressed human
    NADH cytochrome b5 reductase and cytochrome b5. Undergraduate Research Scholars
    Program, University of Wisconsin-Madison. April, 2003.
30. Guzinski M, Maki JE, Yoder AR, Trepanier LA. Measuring the cytotoxicity of
    sulfonamide metabolites to human mononuclear cells using the fluorescent nucleic acid
    dye Yo-Pro-1®. Merck-Merial Veterinary Scholar Symposium, Kansas State University,
    July 31-Aug 3, 2003.

31. Trepanier LA, Yoder AR, Bajad S, Kastman CC, Yoder EM, Maki JE, Beckwith MD,
    Bellehumeur JL, Graziano FM. Impaired detoxification of sulfamethoxazole nitroso in
    HIV infection is due to ascorbate, not thiol, deficiency. 12th North American Meeting of
    the Society for the Study of Xeniobiotic (ISSX). Providence RI, 2003.

32. Trepanier LA, Kurian JR, Miller JL, Bajad S, Chin NA. NADH cytochrome b5 reductase
    and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and
    amidoximes in humans. 12th North American Meeting of the Society for the Study of
    Xeniobiotic (ISSX). Providence RI, 2003.

33. Trepanier LA, Guzinski MV, Maki JE, Yoder AR, Bajad S, Bellehumeur JL, Beckwith
    MD, Graziano FM. Evaluation of intracellular ascorbate deficiency and the cytotoxicity
    of sulfamethoxazole nitroso in healthy and HIV-infected subjects. American Society for
    Clinical Pharmacology and Therapeutics, April 2004.

34. Bajad S, Trepanier LA, Graziano FM. Cytochrome b5 reductase and cytochrome b5
    expression in HIV-infected patients. FASEB/American Society for Pharmacology and
    Experimental Therapeutics, April 2004.

35. Wagner K, Gibbon KJ, Trepanier LA. Safety and efficacy of EMLA topical anesthetic
    cream for placement of jugular catheters in cats. Proc. of the 22nd Annual Forum of the
    ACVIM, Minneapolis, abstr. 128, 2004.

36. Lavergne SN, Volkmann EM, Yoder AR, Trepanier LA. Experiences with a dog model
    of drug hypersensitivity. Drug Hypersensitivity Meeting, Bern Switzerland. May 2004.

37. Trepanier LA. Adverse drug reactions associated with the hemolymphatic system
    Proceedings of the 22nd ACVIM Forum, Minneapolis, CD-ROM Proceedings, June
    2004.

38. Mealey K, Trepanier LA, Weinshilboum RM. Overview & panel discussion: clinical
    value and future use of pharmacogenetics in veterinary medicine. Proceedings of the 22nd
    ACVIM Forum, Minneapolis, CD-ROM Proceedings, June 2004.

39. Lavergne SN, Volkmann E, Danhof R, Grishaber L, Trepanier LA. Anti-
    myeloperoxidase, anti-drug, and drug-dependent anti-platelet antibodies in dogs with
    sulfonamide hypersensitivity. Annual Congress, British Society for Immunology,
    Harrogate, UK, December 2004.

				
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