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DC_HumanCancerV1_0

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DC_HumanCancerV1_0 Powered By Docstoc
					Gene Name                                    Gene Symbol                                   Official Gene Symbol                          General Function                   General Function
*fer                                         *fer                                          *                                             *metabolism                                *


DualChip™ human cancer version 1.0

Gene Name                                                  Gene Symbol                              Official Gene Symbol                   Row      Col 1   Col 2   Col 3       Genbank        Swissprot              General Function                                 Specific Function

Gene Name                                    Gene Symbol                                            Official Gene Symbol                   Row      Col 1   Col 2   Col 3       Genbank        Swissprot              General Function                                 Specific Function

adisintegrinandm                 etalloproteinasedom 17(tum M                   D 17or
                                                                 ain A A necrosis factor, alpha, conv A Aenz m    ertingM y e)
                                                                                                                       D 17                     1     3      14      25      U69611             P78536                    cell m    igration            m  etalloendopeptidaseactiv                     ity
adisintegrinandm                 etalloproteinasedom 9(mA Agam a)ain eltrinM m   D 9                                 AA9DM                      1     4      15      26    NM_003816            Q13443                    cell m    igration            m  etalloendopeptidaseactiv                     ity
abl-interactor 2                                                                A I2B                                  A I2
                                                                                                                          B                     1     5      16      27    NM_005759           Q9BV70                        or
                                                                                                                                                                                                                       tum suppressor                   S 3/S 2adaptor proteinactiv
                                                                                                                                                                                                                                                           H H                                               ity
        in
activ Areceptor ty II-lik 1       pe e                                        CR
                                                                           A V L1                                   A V L1
                                                                                                                       CR                       1     6      17      28 NM_000020               P37023                     A binding
                                                                                                                                                                                                                             TP                         proteink                 K
                                                                                                                                                                                                                                                                     inaseC 2activ               ity
alpha-2-m        acroglobulin                                                    A   2M                                A   2M                   1     7      18      29    NM_000014            P01023                      circulation                 P  roteaseinhibitor andcy inetransporter   tok
am   phiregulin(schw              annom               ed th
                                            a-deriv grow factor)A E                RG                                 AERG                      1     8      19      30 NM_001657               P15514          G thfactors andcy ines
                                                                                                                                                                                                                  row                         tok       G thfactor, G coprotein
                                                                                                                                                                                                                                                           row                  ly
angiopoietin1                                                                   NP
                                                                            A G T1                                 A G T1
                                                                                                                      NP                        1     9      20      31      U83508             Q15389      signal transduction/ angiogenesis           receptor binding
       ia
atax telangiectasiam                                                   plemA
                                       utated(includes com entationgroups A CandD   TM             ,         )         A  TM                    1    10      21      32      U26455             Q13315                       C cy
                                                                                                                                                                                                                                ell cle                 regulator of p53andB C 1            RA
   TP
A -bindingcassette, sub-fam C m ber 1 A C 1         ily , em                     BC                                  AC1BC                      1    11      22      33     AJ003198            P33527                       transport                     rug
                                                                                                                                                                                                                                                        D distribution
   X
A Lreceptor ty            rosinek      inase                                     AL  X                                 AL  X                    2     2      13      24      M76125             P30530                  cell proliferation                         em
                                                                                                                                                                                                                                                        transm branereceptor proteinty                               rosinek      inaseactiv      ity
             iral P
baculov IA repeat-containing5(surv in) B C                       iv               IR 5                               B CIR 5                    2     3      14      25    NM_001168            O15392                       apoptosis                  cy  steineproteaseinhibitor activ                         ity
                  K
basigin(O bloodgroup)                                                           BG  S                                  BG S                     2     4      15      26    NM_001728            P35613                E tracellular m
                                                                                                                                                                                                                        x                  atrix        S ulates m m
                                                                                                                                                                                                                                                           tim              atrix etalloproteinasesy                          nthesis infibroblasts; Tum progressionor
   -cell LL/ly phom
B C m a2                                                                           C
                                                                                B L2                                  B L2
                                                                                                                         C                      2     5      16      27    NM_000633            P10415                      A  poptosis                 R  egulates thedeathcell
   C
B L2-antagonist of cell death                                                   BD  A                                  BD A                     2     7      18      29    NM_004322            Q92934                      A  poptosis                 P  ro-apoptotic; B L2bindingprotein
                                                                                                                                                                                                                                                                                 C
   C
B L2-antagonist/k 1            iller                                           BK A1                                  BKA1                      2     8      19      30      U16811             Q16611     cell cy regulationandproliferation
                                                                                                                                                                                                                   cle                                  A  ccelerates program edcell death bybindingtoB L-2
                                                                                                                                                                                                                                                                                           m                                                      C
   C
B L2-associatedXprotein                                                         BX  A                                   BX  A                   2     9      20      31    NM_004324           Q8WXU1                       A  poptosis                                                          t , ation
                                                                                                                                                                                                                                                        Induces therelaseof cy C activ of caspase-3
   C                           iller
B L2-interactingk (apoptosis-inducing)                                           B   IK                                 B  IK                   2    10      21      32    NM_001197            Q13323                       apoptosis                  apoptosis regulator activ                 ity
   C e
B L2-lik 2                                                                      C
                                                                              B L2L2                                B L2L2
                                                                                                                       C                        3     1      12      23    NM_004050            Q92843                       apoptosis                  apoptosis regulator activ                 ity
   C
B L2-relatedproteinA                  1                                         C 1
                                                                             B L2A                                  B L2A
                                                                                                                       C 1                      3     2      13      24    NM_004049            Q16548                       apoptosis                  apoptosis regulator activ                 ity
bigly   can                                                                     BN  G                                  BN G                     3     4      15      26 NM_0017113              P21810                ex  tracellular m    atrix        ex                    atrix
                                                                                                                                                                                                                                                            tracellular m structural constituent
bonem        orphogenetic protein1                                             BP  M1                                 BPM1                      3     5      16      27      M22488             P13497                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok        cy ineactiv
                                                                                                                                                                                                                                                            tok             ity
       D ighly
23K aH basic protein                                                            23k    d                            R L13A
                                                                                                                       P                        3     6      17      28       X56932            P39023               H  ouseK     eepinggene            H  ouseK    eepinggene
                  ed
brain-deriv neurotrophic factor                                                BN  DF                                 BNDF                      3     7      18      29      M61176             P23560                     grow factor
                                                                                                                                                                                                                                  th                    grow factor activ
                                                                                                                                                                                                                                                               th                   ity
   RA
B C 1associatedR Gdom 1             IN            ain                         BR1AD                                  BR1AD                      3     8      19      30 NM_000465               Q99728                 tum suppressor
                                                                                                                                                                                                                             or                         tum suppressor
                                                                                                                                                                                                                                                              or
breast cancer 2, earlyonset                                                   BC2RA                                  BC2RA                      3    10      21      32    NM_000059            P51587                 tum suppressor
                                                                                                                                                                                                                             or                         single-strandedD Abinding  N
                         pe B
cadherin11, ty 2, O -cadherin(osteoblast) C H                                    D 11                                CH D 11                    3    11      22      33    NM_001797            P55287                      ell
                                                                                                                                                                                                                          C adhesion                    M  ediates cell-cell interactions; m hav aroleinboneform     ay e                                   ation
cadherin12, ty 2(N       pe -cadherin2)                                       CH D 12                                CH D 12                    4     1      12      23    NM_004061            P55289                      ell
                                                                                                                                                                                                                          C adhesion                       ole
                                                                                                                                                                                                                                                        R duringtheneuronal dev                            elopm      ent
cadherin13, H            -cadherin(heart)                                     CH D 13                                CH D 13                    4     2      13      24      U59289             P55290                    C adhesion
                                                                                                                                                                                                                            ell                                or
                                                                                                                                                                                                                                                        Tum suppressor inbreast cancer
   AP                   IP 1 ain
C S 2andR K dom containingadaptor wC deathdom                                   RD
                                                                             ith A D ain                            CADRD                       4     3      14      25 NM_003805               P78560                       apoptosis                  apoptosis regulator activ                 ity
   AP                   AD e
C S 8andF D -lik apoptosis regulator                                             F R
                                                                              C LA                                       F R
                                                                                                                      C LA                      4     4      15      26    NM_003879            O15519                       apoptosis                  caspaseactiv         ity
caspase1, apoptosis-relatedcy                                                 C S 1in
                                                                                 AP
                                                     steineprotease(interleuk 1, beta, conv              ertase) C S 1  AP                      4     5      16      27      M87507             P28906                       apoptosis                  caspaseactiv         ity
caspase2, apoptosis-relatedcy                        steineprotease(neural 2     AP
                                                                              C S precursor cell ex      pressed) C S 2 AP                      4     6      17      28    NM_001224            P42575                      A  poptosis                    ctiv
                                                                                                                                                                                                                                                        A atedincy ic stress,requiredfor theperm
                                                                                                                                                                                                                                                                              totox                                                                   ation itochondria,requiredfor stress-inducedapoptosis
                                                                                                                                                                                                                                                                                                                                             eabiliz of m
caspase3, apoptosis-relatedcy                        steineprotease C S 3        AP                                   CS3AP                     4     7      18      29    NM_004346            P42574                      A  poptosis                 Initiationof apoptotic cell death; P R cleav protease         AP                age
caspase8, apoptosis-relatedcy                        steineprotease C S 8        AP                                   CS8AP                     4     8      19      30       X98172            O15519                      A  poptosis                                            AP
                                                                                                                                                                                                                                                        Thiol protease; P R cleav protease=              age                       signatureapoptotic fragm           ents
caspase9, apoptosis-relatedcy                        steineprotease C S 9        AP                                  CS9AP                      4     9      20      31    NM_001229            P55211                      A  poptosis                 P  articipates incaspase-3activ inv                     ation itro.
catenin(cadherin-associatedprotein), alpha1, 102k N 1                       C DATNa                                     TN A
                                                                                                                     C N1                       4    10      21      32    NM_001903            P35221                      ell
                                                                                                                                                                                                                          C adhesion                        tosk
                                                                                                                                                                                                                                                        cy eleton
      eolin
cav 1, cav                eolaeprotein, 22k a         D                        CV  A1                                  CV  A1                   4    11      22      33    NM_001753            Q03135                          ell cle
                                                                                                                                                                                                                             C cy                              or
                                                                                                                                                                                                                                                        Tum suppressor andstructural com                                                        eolar em
                                                                                                                                                                                                                                                                                                                             ponent of cav m branes
   D
C 27-binding(S a) protein   iv                                                  S AIV                                 S AIV                     5     2      13      24     AF033111            O15304                       apoptosis                  receptor signalingproteinactiv                         ity
   D
C 34antigen                                                                        D
                                                                                C 34                                       D
                                                                                                                        C 34                    5     3      14      25    NM_001773            P28906                    cell adhesion                 cell adhesionm           oleculeactiv              ity
   D                                        pe
C 36antigen(collagenty I receptor, throm C 36receptor)                  bospondin  D                                  C 36
                                                                                                                         D                      5     4      15      26    NM_000072            P16671                     cell adhesion                receptor for throm         bospondinandcollageninplatelets
   D
C 59antigenp18-20                                                                  D
                                                                                C 59                                       D
                                                                                                                        C 59                    5     5      16      27      M27909                /                       m
                                                                                                                                                                                                                       im uneresponse                      m te
                                                                                                                                                                                                                                                        ly phocy antigen
   D
C 9antigen(p24)                                                                  C9  D                                   C9 D                   5     7      18      29    NM_001769            P21926                  cell proliferation              integral toplasm m brane  a em
   D -lik inase1
C C ek                                                                          C 1LK                                   C 1LK                   5     8      19      30    NM_004071           Q8N5V8                        cell cy   cle              proteinserine/threoninek                    inaseactiv            ity
A  ldolaseA        ,                                                            A   ldo                               A OLD A                   5     9      20      31    NM_000034            P04075               H  ouseK     eepinggene            H  ouseK    eepinggene
            ision cle 1
cell div cy 2, G toSandG toM                              2                    CC D2                                   CC D2                    5    10      21      32       X05360               /                        cell cy   cle               cy  clin-dependent proteink                  inaseactiv             ity
            ision cle                    TP
cell div cy 42(G bindingprotein, 25k a)D 42                                DC C                                       CC D 42                   5    11      22      33    NM_001791            P21181                       ell
                                                                                                                                                                                                                          C structure                      TP
                                                                                                                                                                                                                                                        G -bindingprotein
               th
cell grow regulatoryw ringfinger dom    ith                        ain C R F    G R1                                 CRFG R1                    6     1      12      23    NM_006568            Q99675                      cell grow    th                        e
                                                                                                                                                                                                                                                        negativ regulationof cell activ                         ity
          ok           -X otif)
chem ine(C -Cm ligand12(strom cell-derivL12 1)                    al         C C factor
                                                                                X ed                                 CC X L12                   6     2      13      24    NM_000609            P48061                 im uneresponse
                                                                                                                                                                                                                           m                            antiv responseproteinactiv
                                                                                                                                                                                                                                                               iral                                           ity
A  lpha-tubulin                                                                 Tubu                                 -A H -1
                                                                                                                   K LP A                       6     3      14      25    NM_006082            P78395               H  ouseK     eepinggene            H  ouseK    eepinggene
          ok
chem ine(C -Cm ligand9 -X otif)                                               CC X L9                                 CC X L9                   6     4      15      26    NM_002416            Q07325                     m
                                                                                                                                                                                                                       im uneresponse                            ok
                                                                                                                                                                                                                                                        chem ineactiv           ity
chondroitinsulfateproteogly 2(v                can ersican) C P 2                SG                                   CP2SG                     6     5      16      27       J02814            P13611                ex  tracellular m    atrix        proteogly     can
ciliaryneurotrophic factor                                                     C F TN                                  C F TN                   6     6      17      28    NM_000614            P26441                            th
                                                                                                                                                                                                                           grow factor                         th
                                                                                                                                                                                                                                                        grow factor activ           ity
                   pe
collagen, ty I, alpha2                                                          O 2
                                                                             C L1A                                   C L1A
                                                                                                                        O 2                     6     7      18      29    NM_000089            P08123                ex  tracellular m    atrix        ex                    atrix
                                                                                                                                                                                                                                                            tracellular m structural constituent
                   pe                             ary
collagen, ty II, alpha1(prim osteoarthritis, spondy1                            O loepiphy dy
                                                                             C L2A            seal splasia, congenital)1
                                                                                                                     C L2A
                                                                                                                        O                       6     8      19      30       X16468            P02458              sk eletal dev     elopem   ent      sk  eletal dev    elopm     ent
                   pe I,
collagen, ty V alpha1                                                           O 1
                                                                             C L6A                                      O 1
                                                                                                                     C L6A                      6     9      20      31    NM_001848            P12109                    cell adhesion                 cell adhesionm           oleculeactiv              ity
colonystim                                                        erly cD S 1R
                   ulatingfactor 1receptor, form M C F felinesarcom v (v s)C F onough                  a iral -fm S 1R                          6    10      21      32    NM_005211            P07333               ell
                                                                                                                                                                                                                   C signaling/ receptor                A  nti-pathogenresponse; receptor for m                               acrophagestim         ulatingfactor
                 e
connectiv tissuegrow factor            th                                      C F TG                                  C F TG                   6    11      22      33      U14750             P29268            row
                                                                                                                                                                                                                G thfactors andcy ines        tok       E  piderm dev
                                                                                                                                                                                                                                                                    al elopm             ent;connectiv tissu grow factor
                                                                                                                                                                                                                                                                                                                     e                    th
cy Aclin 2                                                                    CN2CA                                   CN2CA                     7     1      12      23 NM_001237               P20248                         m  itosis                R                        clin
                                                                                                                                                                                                                                                           egulationof cy dependant k                               inaseactiv       ity
cy Bclin 1                                                                    CN1CB                                   CN1CB                     7     2      13      24    NM_031966            P14635                          ell cle
                                                                                                                                                                                                                             C cy                          2 itotic
                                                                                                                                                                                                                                                        G m specific cy                     clin
    clin 1 R D
cy D (P A 1: parathy adenom                 roid               atosis 1) C N 1   CD                                   CN1CD                     7     3      14      25    NM_053056            P24385                          ell cle
                                                                                                                                                                                                                             C cy                       R  egulatorysubunit of C K or C K      D4 D6
cy Eclin 1                                                                    CN1CE                                   CN1CE                     7     4      15      26    NM_001238            P24864                          ell cle
                                                                                                                                                                                                                             C cy                       R  egulators of C Kk    D inases; essential for thecontrol of thecell cy at theG transition                cle          1/S
cy Gclin                                                                      CN1CG                                    ccng1                    7     5      16      27      U53328             P51959                          ell cle
                                                                                                                                                                                                                             C cy                          G
                                                                                                                                                                                                                                                        R 1/Sspecific cy            clin
cy Hclin                                                                       CN CH                                   CN CH                    7     6      17      28    NM_001239            P51946                       C cy
                                                                                                                                                                                                                                ell cle                 P                 lates
                                                                                                                                                                                                                                                           hosphosry andactiv cy                      ates clin-dependant proteink                                                             cle
                                                                                                                                                                                                                                                                                                                                                        inases intheregulationof cell cy progression
cy  clin-dependent k                          D 2-lik
                                inase(C C e) 10                               CK D 10                                 CK D 10                   7     7      18      29       L33264           Q9UHL7                       cell cy   cle               proteinserine/threoninek                    inaseactiv            ity
cy  clin-dependent k            inase2                                         CK  D2                                  cdk2                     7     8      19      30    NM_001798            P24941                          ell cle
                                                                                                                                                                                                                             C cy                       cy  clin-dependent proteink                  inaseactiv             ity
cy  clin-dependent k            inase4                                         CK  D4                                   cdk4                    7     9      20      31      U79269             P11802                          ell cle
                                                                                                                                                                                                                             C cy                                      ity
                                                                                                                                                                                                                                                        Theactiv of this k              inaseis restrictedtotheG phase; cell proliferation1-S
cy  clin-dependent k            inase6                                         CK  D6                                   cdk6                    7    10      21      32    NM_001259            Q00534                          ell cle
                                                                                                                                                                                                                             C cy                                        ith -ty clins
                                                                                                                                                                                                                                                        Interacts w D pecy andphosphory pR inG                                      late B 1-phase
cy  clin-dependent k            inaseinhibitor 1A(p21, C D N          ip1)C K 1A                                     C K 1A
                                                                                                                        DN                      7    11      22      33      U03106             P38936                          ell cle
                                                                                                                                                                                                                             C cy                       Inhibitor 1Aof G         1-specific C K clincom esD -cy                     plex
cy  clin-dependent k            inaseinhibitor 1B(p27)                          DN
                                                                            C K 1B                                   C K 1B
                                                                                                                        DN                      8     1      12      23    NM_004064            P46527                          ell cle
                                                                                                                                                                                                                             C cy                       Inhibitor of G                             D -cy
                                                                                                                                                                                                                                                                            1-specific C K clincom es 1B m                     plex           ; ediates TG beta-inducedG phasearrest
                                                                                                                                                                                                                                                                                                                                                                 F                  1
cy  clin-dependent k            inaseinhibitor 1C(p57, K D N          ip2)C K 1C                                     C K 1C
                                                                                                                        DN                      8     2      13      24    NM_000076            P49918                          ell cle
                                                                                                                                                                                                                             C cy                       Inhibits G                           D -cy                          plex
                                                                                                                                                                                                                                                                         1-specific C K clincom es,negativ regulator of cell proliferation.     e
cy  clin-dependent k            inaseinhibitor 2A(m             elanom C K 2A C K
                                                                           a, p16, inhibits D 4)
                                                                                DN                                      DN
                                                                                                                     C K 2A                     8     4      15      26       L27211           Q8N726                           ell cle
                                                                                                                                                                                                                             C cy                       Inhibitor of G      1-specific C K clincom es 2A tum suppressor gene
                                                                                                                                                                                                                                                                                                   D -cy                       plex           ,       or
cy  clin-dependent k            inaseinhibitor 2B(p15, inhibits CN4)        C KKDD2B                                    DN
                                                                                                                     C K 2B                     8     5      16      27      U17075             Q8NIA6                       cell cy   cle              cy  clin-dependent proteink                  inaseinhibitor activ                ity
   eta-A
B ctin                                                                         A TBC                                   A TBC                    8     6      17      28    NM_001101            P02570               H  ouseK     eepinggene            H  ouseK    eepinggene
cy  clin-dependent k            inaseinhibitor 2C(p18)                      C K 2C
                                                                                DN                                      DN
                                                                                                                     C K 2C                     8     7      18      29     AF041248           Q9P1T2                        cell cy   cle              cy  clin-dependent proteink                  inaseinhibitor activ                ity
cy  clin-dependent k            inaseinhibitor 2D(p19, inhibits CN4)        C KKDD2D                                    DN
                                                                                                                     C K 2D                     8     8      19      30      U40343             P55273                      cell cy   cle               cy  clin-dependent proteink                  inaseinhibitor activ                ity
cy  clin-dependent k                          e D 2-relatedk C K
                                inase-lik 1(C C                           inase) L1
                                                                                 D                                    CK D L1                   9     2      13      24
                                                                                                                                                                    NM_004196                   Q00532                      cell cy   cle               proteinserine/threoninek                    inaseactiv            ity
    tok
cy eratin2                                                                  U C T2A
                                                                          H MY                                       U C T2A
                                                                                                                  H MY                          9     3      14      25    NM_015848               /                           tosk
                                                                                                                                                                                                                           cy eleton                    structural m      oleculeactiv            ity
decorin                                                                         DN  C                                   DN  C                   9     4      15      26      M14219             P07585                     atrix
                                                                                                                                                                                                                        m assem            bly          chondroitinsulfate/derm sulfateproteogly atan                                   can
desm      in                                                                    DS  E                                   DS  E                   9     5      16      27    NM_001927            P17661                         tosk
                                                                                                                                                                                                                           cy eleton                    structural constituent of cy eleton           tosk
desm      ocollin1                                                             DC  S1                                  DC  S1                   9     7      18      29       X72925            Q08554                    cell adhesion                 cell adhesionm           oleculeactiv              ity
desm      oglein1                                                              DG  S1                                  DG  S1                   9     8      19      30     AF097935            Q02413                      ell
                                                                                                                                                                                                                          C adhesion                       ly
                                                                                                                                                                                                                                                        G coprotein
desm in   oplak                                                                 DP  S                                   DP  S                   9     9      20      31    NM_004415            P15924             tosk
                                                                                                                                                                                                                cy eleton/ cell adhesion                structural constituent of cy eleton           tosk
   N -dam
D A age-inducibletranscript 3                                                     D
                                                                               D IT3                                   D IT3
                                                                                                                          D                     9    10      21      32       S40706            P35638                N
                                                                                                                                                                                                                    D Arepair / sy        nthesis          N           age
                                                                                                                                                                                                                                                        D Adam response; transcriptionco-repressor
   2F
E transcriptionfactor 1                                                         E 12F                                   E 12F                  10     1      12      23 NM_005225               Q01094                    Transcription                        or
                                                                                                                                                                                                                                                        Tum suppressor, Transcriptionfactor
   2F
E transcriptionfactor 3                                                         E 32F                                   E 32F                  10     2      13      24    NM_001949            O00716                    Transcription                 Transcriptionfactor; binds R protein               b
   2F
E transcriptionfactor 4                                                         E 42F                                   E 42F                  10     3      14      25    NM_001950            Q16254                    Transcription                    N
                                                                                                                                                                                                                                                        D Abindingproteinrequiredfor transcription; binds p107, p130proteins
   2F
E transcriptionfactor 5, p130-binding                                           E 52F                                   E 52F                  10     4      15      26      U31556             Q15329                    Transcription                 Transcriptionfactor, D Abinding      N
                 th
earlygrow response1                                                            ER  G1                                  ER  G1                  10     5      16      27    NM_001964            P18146                    Transcription                    arly th
                                                                                                                                                                                                                                                        E grow responsegene;Tum suppressor                          or
E  -cadherin                                                                   CH D1                                   CH D1                   10     6      17      28    NM_004360            P12830                      ell
                                                                                                                                                                                                                          C adhesion                    M  ediates cell-cell interactions inepithelial cells
endothelin2                                                                    EN  D2                                  EN  D2                  10     7      18      29      M65199             P20800                            th
                                                                                                                                                                                                                          grow factor                          th
                                                                                                                                                                                                                                                        grow factor activ           ity
env inoplak                                                                    EP VL                                   EP  VL                  10     8      19      30    NM_001988            Q92817                         tosk
                                                                                                                                                                                                                           cy eleton                    structural m      oleculeactiv            ity
ephrin-A      1                                                               EN1FA                                   EN1FA                    10     9      20      31      M57730             P20827                signal transduction               receptor binding
              al          th
epiderm grow factor (beta-urogastrone)                                           EF  G                                   EF G                  10    10      21      32    NM_001963            P01133                            th
                                                                                                                                                                                                                          grow factor                   epiderm grow factor receptor activ ligandactiv
                                                                                                                                                                                                                                                                    al         th                                           ating                   ity
ery  thropoietinreceptor                                                       EO  PR                                  EO  PR                  10    11      22      33    NM_000121            P19235                signal transduction               guany    l-nucleotideex          changefactor activ                    ity
   A T inase
FS k                                                                          FSA TK                                  FSA TK                   11     2      13      24       X86779            Q14296                  stress response                 proteinserine/threoninek                    inaseactiv            ity
                         th
fibroblast grow factor 1(acidic)                                                FF G1                                   FF G1                  11     3      14      25       X51943            P05230                            th
                                                                                                                                                                                                                          grow factor                          th
                                                                                                                                                                                                                                                        grow factor activ           ity
                         th
fibroblast grow factor 2(basic)                                                 FF G2                                   FF G2                  11     4      15      26    NM_002006            P09038            row
                                                                                                                                                                                                                G thfactors andcy ines        tok       M  itogenic, angiogenic, andneurotrophic factor
                         th
fibroblast grow factor receptor 1(fm                                        rosine 1 2, P
                                                            s-relatedty F F k    G Rinase feiffer sy       ndrom F F 1
                                                                                                                 e) G R                        11     5      16      27    NM_000604            P11362               ell
                                                                                                                                                                                                                   C signaling/ receptor                G cosy receptor ty
                                                                                                                                                                                                                                                           ly lated                             rosinek          inasethat binds bothacidic andbasic fibroblast grow factors             th
fibronectin1                                                                     F1 N                                    F1 N                  11     6      17      28      M10905             P02751                  x
                                                                                                                                                                                                                      E tracellular m      atrix             olv
                                                                                                                                                                                                                                                        Inv edincell adhesionandm                                igrationprocesses
   K
F 506bindingprotein12-rapamcinassociatedprotein1     y                        FA1
                                                                                RP                                      RP
                                                                                                                      FA1                      11     7      18      29    NM_004958            P42345                       cell cy   cle              inositol/phosphatidy             linositol k         inaseactiv          ity
fm  s-relatedty       rosinek      inase1(v                                      grow
                                                   ascular endothelialF thfactor/v LT1         ascular perm    eabilityF receptor)
                                                                                                                         factor
                                                                                                                           LT1                 11     8      19      30    NM_002019            P17948                    angiogenesis                  receptor activ      ity
folatehy      drolase(prostate-specific m braneantigen) 1  em                  F LH
                                                                                 O 1                                     O 1
                                                                                                                       F LH                    11     9      20      31    NM_004476            Q04609            m  etallopeptidaseactiv        ity    am   inopeptidaseactiv             ity
G  ardner-R      asheedfelinesarcom v (v oncogenehom a iral -fgr)                F R olog
                                                                                    G                                    FR G                  11    10      21      32    NM_005248            P00544                      cell grow    th             proteinty     rosinek     inaseactiv            ity
glutathione-S                                  e;
                       -transferaselik glutathionetransferaseom            G TTLp28
                                                                              S           ega                         S
                                                                                                                   G TTLp28                    12     1      12      23    NM_004832            P78417                 D mrug etabolism                 G  lutathion (phaseII)
        th                        N -dam
grow arrest andD A age-inducible, alpha A D                                G D 45A                                     AD
                                                                                                                    G D 45A                    12     2      13      24    NM_001924            P24522                  stress response                 glutathionetransferaseactiv                       ity
        th
grow arrest-specific 1                                                         GS  A1                                  GS  A1                  12     3      14      25    NM_002048            P54826                         N
                                                                                                                                                                                                                            D Arepair                   structural constituent of ribosom                          e
        th
grow factor receptor-boundprotein2                                             GB  R2                                  GB  R2                  12     4      15      26    NM_002086            P29354                          ell cle
                                                                                                                                                                                                                             C cy                          ell
                                                                                                                                                                                                                                                        C structure
hem    opoietic cell k         inase                                            HK  C                                   HK  C                  12     5      16      27    NM_002110            P08631                       TP
                                                                                                                                                                                                                           A binding                    proteinty     rosinek     inaseactiv            ity
heparansulfateproteogly 2(perlecan)        can                                HP2SG                                   HP2SG                    12     6      17      28    NM_005529            O43834                    cell adhesion                 structural m      oleculeactiv            ity
               te th
hepatocy grow factor (hepapoietinA scatter factor)              ;                HF  G                                   HF G                  12     7      18      29       X16323            P14210             row
                                                                                                                                                                                                                 G thfactor andcy ines       tok        E bry dev
                                                                                                                                                                                                                                                           m onic elopm                   ent
hepatom                   ed th
               a-deriv grow factor (high-m                                     HG
                                                               obilitygroupprotein1-lik
                                                                                   DF         e)                       HG  DF                  12     8      19      30    NM_004494            P51858                    grow factor
                                                                                                                                                                                                                                  th                    grow factor activ
                                                                                                                                                                                                                                                               th                   ity
   y
Cclophilin33A                                                                    cy   c                                 P IE
                                                                                                                           P                   12     9      20      31     AF042385           Q9UNP9                H  ouseK     eepinggene            H  ouseK    eepinggene
   G
H Factiv         ator                                                         HFCGA                                   HFCGA                    12    10      21      32    NM_001528            Q04756             row
                                                                                                                                                                                                                 G thfactor andcy ines       tok        A ates hepatocy grow factor
                                                                                                                                                                                                                                                           ctiv                       te th
hy  aluronanbindingprotein2                                                   HB2AP                                   HB2AP                    12    11      22      33    NM_004132           Q8IWX2                            th
                                                                                                                                                                                                                          grow factor                         m psin ity
                                                                                                                                                                                                                                                        chy otry activ
hy  aluronan-m                         otility
                      ediatedm receptor (R A M H M               H M) MR                                               HM  MR                  13     2      13      24      U29343             O75330                      cell m   otility            hy  aluronic acidbinding
         tok
IKcy ine, dow               n-regulator of H II     LA                             IK                                      IK                  13     3      14      25    NM_006083           Q95HA6                   th
                                                                                                                                                                                                                 grow factor andcy ine       tok            tok
                                                                                                                                                                                                                                                        cy ineactiv         ity
                           th ily em
inhibitor of grow fam , m ber 1                                                 IN 1 G                                  IN 1 G                 13     4      15      26    NM_005537            O00532                       or
                                                                                                                                                                                                                      Tum suppressor                       row
                                                                                                                                                                                                                                                        G thregulator ; Tum suppressor       or
                 e th
insulin-lik grow factor 1(som edinC                 atom             )          IG 1 F                                  IG 1 F                 13     5      16      27       X57025            P01343             row
                                                                                                                                                                                                                 G thfactor andcy ines       tok        M  uscle/sk     eletal dev                   ent; row
                                                                                                                                                                                                                                                                                       elopm G thfactor
                 e th
insulin-lik grow factor 1receptor                                              IG 1RF                                  IG 1RF                  13     7      18      29    NM_000875            P08069               ell
                                                                                                                                                                                                                   C signaling/ receptor                A  nti-apoptotic; receptor
                 e th
insulin-lik grow factor bindingprotein2, 36k a F P                        DIG B 2                                         FP
                                                                                                                      IG B 2                   13     8      19      30      M35410             P18065             row
                                                                                                                                                                                                                 G thfactor andcy ines       tok           row
                                                                                                                                                                                                                                                        G thfactor m            odulation
                 e th
insulin-lik grow factor bindingprotein3                                           FP
                                                                              IG B 3                                  IG B 3
                                                                                                                          FP                   13     9      20      31       X64875            P17936             row
                                                                                                                                                                                                                 G thfactor andcy ines       tok           row
                                                                                                                                                                                                                                                        G thfactor m            odulation
integrinbeta3bindingprotein(beta3-endonex B P                            in) 3B                                     B P 3B )
                                                                                                                ITG 3B (B P                    13    10      21      32    NM_014288           Q9UKB6                     cell adhesion                 receptor activ      ity
integrin, alpha1                                                               ITG 1  A                                ITG 1  A                14     1      12      23    NM_181501            P56199                    cell adhesion                 cell adhesionreceptor activ                     ity
                                              D ,
integrin, alpha4(antigenC 49D alpha4subunitITGLA receptor)                            A
                                                                                of V4 -4                               ITG 4  A                14     2      13      24    NM_000885            P13612                    cell adhesion                 receptor activ      ity
                                                                         peptide, 1
integrin, beta1(fibronectinreceptor, betapoly ITG antigenC 29includes M F ITG12)      B        D                D 2, M K1 SB                   14     4      15      26    NM_002211            P05556                      ell
                                                                                                                                                                                                                          C adhesion                    Integrin; F     ibronectinreceptor
integrin-link k    ed inase                                                      ILK                                      ILK                  14     5      16      27    NM_004517            Q13418                  stress response                 proteinserine/threoninek                    inaseactiv            ity
   ly
G ceraldehy           de-3-phosphate-dehy              drogenase G P               AD                                  GP  AD                  14     6      17      28    NM_002046            P04406               H  ouseK     eepinggene            H  ouseK    eepinggene
interferon(alpha, betaandom receptor 1 IF A 1     ega)                           NR                                      NR
                                                                                                                      IF A 1                   14     7      18      29    NM_000629            P17181                signal transduction               receptor activ      ity
interferongam areceptor m                                                        NR
                                                                              IF G 1                                     NR
                                                                                                                      IF G 1                   14     8      19      30    NM_000416            P15260                     m
                                                                                                                                                                                                                       im uneresponse                          iral
                                                                                                                                                                                                                                                        antiv responseproteinactiv                            ity
interferonregulatoryfactor 1                                                    IR 1 F                                  IR 1 F                 14    10      21      32    NM_002198            P10914                transcriptionfactor               transcriptionfactor activ                ity
interferon, gam a        m                                                      IF G N                                  IF G N                 14    11      22      33       X13274            P01579            row
                                                                                                                                                                                                                G thfactors andcy ines        tok       A  nti-pathogenresponse, Interferon
              in
interleuk 1, alpha                                                              IL1A                                    IL1A                   15     1      12      23    NM_000575            P01583             row
                                                                                                                                                                                                                 G thfactor andcy ines       tok           ay                         plify
                                                                                                                                                                                                                                                        M initiateandam theim uneandinflam atoryresponses    m                             m
interleuk 10  in                                                                 IL10                                    IL10                  15     2      13      24    NM_000572            P22301            row
                                                                                                                                                                                                                G thfactors andcy ines        tok          hem is; y ine nthesis inhibitoryfactor
                                                                                                                                                                                                                                                        C otax Ctok sy
interleuk 11  in                                                                 IL11                                    IL11                  15     3      14      25    NM_000641            P20809             row
                                                                                                                                                                                                                 G thfactor andcy ines       tok           trom                    ed tok
                                                                                                                                                                                                                                                        S al cell-deriv cy ine; actiononhem                                           atopoietic cells
interleuk 13  in                                                                 IL13                                    IL13                  15     4      15      26    NM_002188            P35225                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok        signal transducer activ               ity
interleuk 15  in                                                                 IL15                                    IL15                  15     5      16      27    NM_000585            P40933           G thfactor andcy ines
                                                                                                                                                                                                                   row                       tok        A  nti-pathogenresponse; Ctok                   y ine
interleuk 2   in                                                                  IL2                                     IL2                  15     6      17      28      U25676             Q13169          G thfactors andcy ines
                                                                                                                                                                                                                  row                         tok       A  nti-pathogenresponse, G thfactor            row
              in                  -stim
interleuk 3(colony ulatingfactor, m                               ultiple) IL3                                            IL3                  15     7      18      29      M20137                /              row
                                                                                                                                                                                                                G thfactors andcy ines        tok       N  eurogenesis, G thfactorrow
interleuk 4   in                                                                  IL4                                     IL4                  15     8      19      30    NM_000589            P05112            row
                                                                                                                                                                                                                G thfactors andcy ines        tok             ell
                                                                                                                                                                                                                                                        TC proliferation; Ctok              y ine
              in                  -stim
interleuk 5(colony ulatingfactor, eosinophil) IL5                                                                         IL5                  15     9      20      31    NM_000879            P05113                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok            tok
                                                                                                                                                                                                                                                        cy ineactiv         ity
              in
interleuk 6(interferon, beta2)                                                    IL6                                     IL6                  15    10      21      32    NM_000600            P05231           G thfactor andcy ines
                                                                                                                                                                                                                   row                       tok        induces them         aturationof Bcells intoim unoglobulin-secretingcellsm
              in
interleuk 6receptor                                                             IL6R                                    IL6R                   15    11      22      33    NM_000565            P08887               ell
                                                                                                                                                                                                                   C signaling/ receptor                                 ith
                                                                                                                                                                                                                                                        Interacts w thesignal transducer gp130(IL6S                                         T)
interleuk 8   in                                                                  IL8                                     IL8                  16     2      13      24 NM_000584               P10145          G thfactors andcy ines
                                                                                                                                                                                                                  row                         tok          hem ine
                                                                                                                                                                                                                                                        C ok that regulatecell traffick of v                             ing arious ty of leuk tes; roleindev
                                                                                                                                                                                                                                                                                                                                                pes            ocy                  elopm ent,hom                           m
                                                                                                                                                                                                                                                                                                                                                                                                  eostasis,functionintheim unesystem
junBproto-oncogene                                                             JU B  N                                 JU B  N                 16     3      14      25    NM_002229            P17275                transcriptionfactor               transcriptionfactor activ                ity
junctionplak          oglobin                                                    JU   P                                  JU   P                16     4      15      26      M23410             P14923                    cell adhesion                 cell adhesionm           oleculeactiv              ity
K  angai 1                                                                      K I1A                                   K I1A                  16     5      16      27    NM_002231            P27701             cle
                                                                                                                                                                                                           cell cy regulationandproliferation           A ationantigenof Tcells; m
                                                                                                                                                                                                                                                           ctiv                                                 etastasis suppressor gene; M branegly           em            coprotein
k                             oly perk
  eratin1(epiderm tic hy eratosis)                                             K T1R                                   K T1R                   16     7      18      29 NM_006121                  /                     ell
                                                                                                                                                                                                                      C differentiation                 E           al
                                                                                                                                                                                                                                                           piderm differentiation, Ctosk                y eletal protein
k                               oly perk
  eratin10(epiderm tic hy eratosis; k                              eratosis palm et plantaris)
                                                                              K T10
                                                                                 R aris                                  R
                                                                                                                      K T10                    16     8      19      30 NM_000421               P13645                C differentiation
                                                                                                                                                                                                                         ell                            E           al
                                                                                                                                                                                                                                                           piderm differentiation, Ctosk                y eletal protein
   ex inase1
H ok                                                                             H1  K                                   H1 K                  16     9      20      31      M75126             P19367               H  ouseK     eepinggene            H  ouseK    eepinggene
k                               oly
  eratin14(epiderm sis bullosasim , D ling-M K               plex ow K T14 oebner)
                                                                                 Reara,                                  R
                                                                                                                      K T14                    16    10      21      32 NM_000526               P02533                   ell
                                                                                                                                                                                                                      C differentiation                 E           al
                                                                                                                                                                                                                                                           piderm differentiation, Ctosk                y eletal protein
k eratin18                                                                       R
                                                                              K T18                                      R
                                                                                                                      K T18                    17     1      12      23       X12881            P05783                   ell
                                                                                                                                                                                                                      C differentiation                 structural constituent of cy eleton           tosk
k eratin4                                                                      K T4R                                   K T4R                   17     2      13      24    NM_002272            P19013                   ell
                                                                                                                                                                                                                      C differentiation                 structural m      oleculeactiv            ity
   y anthinephosphoribosy
Hpox                                            ltransferase1                  HR  PT                                 HR P T1                  17     3      14      25    NM_000194            P00492               H  ouseK     eepinggene            H  ouseK    eepinggene
k                             oly
  eratin5(epiderm sis bullosasim , D ling-MT5 obner/W      plex ow Keara/K         R                      ock ne pes)
                                                                                                  eber-C ay ty K T5        R                   17     4      15      26    NM_000424            P13647                C differentiation
                                                                                                                                                                                                                         ell                            structural m      oleculeactiv            ity
k eratin6                                                                        R
                                                                              K T6A                                      R
                                                                                                                      K T6A                    17     5      16      27 NM_005554               P02538                   ell
                                                                                                                                                                                                                      C differentiation                 E           al
                                                                                                                                                                                                                                                           piderm differentiation, Ctosk                y eletal protein
k eratin8                                                                      K T8R                                   K T8R                   17     6      17      28    NM_002273            P05787                   ell
                                                                                                                                                                                                                      C differentiation                 structural m      oleculeactiv            ity
k                             ain
  inaseinsert dom receptor (aty III receptor tyK R k     pe                         D
                                                                                rosine inase)                           KR  D                  17     7      18      29    NM_002253            P35968                    angiogenesis                  receptor activ      ity
   iS -1 etastasis-suppressor
K S m                                                                           k iss1                                  k iss1                 17     8      19      30    NM_002256            Q15726             cle
                                                                                                                                                                                                           cell cy regulationandproliferation           R  egulationof cancer m                etastasis; m             etastasis suppressor gene
   IT
K ligand                                                                       K  ITLG                                 K  ITLG                 17    10      21      32    NM_000899            P21583                    cell adhesion                 stemcell factor receptor binding
       em
leuk iainhibitoryfactor (cholinergic differentiationfactor)                       LIF                                     LIF                  17    11      22      33    NM_002309            P17777                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok            tok
                                                                                                                                                                                                                                                        cy ineactiv         ity
                   N , TP
ligaseIII, D A A -dependent                                                     LIG    3                                LIG    3               18     1      12      23       X84740            P49916                         N
                                                                                                                                                                                                                            D Arepair                      N
                                                                                                                                                                                                                                                        D Abinding
               , N , TP
ligaseIV D A A -dependent                                                       LIG    4                                LIG    4               18     2      13      24    NM_002312            P49917              TP N recom
                                                                                                                                                                                                                  A /D A                   bination        N
                                                                                                                                                                                                                                                        D Abinding
lipopoly     saccharide-inducedTN factor            F                          LITA    F                               LITA    F               18     3      14      25    NM_004862            Q99732                transcriptionfactor                  N          m
                                                                                                                                                                                                                                                        R Apoly eraseII transcriptionfactor activ                                   ity
m  acrophagem                                                       cosy M
                         igrationinhibitoryfactor (gly lation-inhibitingfactor)      IF                                   M  IF                18     4      15      26    NM_002415            P14174                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok        cy ineactiv
                                                                                                                                                                                                                                                            tok             ity
m matrix etalloproteinase1(interstitial collagenase)M 1                        MP                                      MP  M1                  18     5      16      27    NM_002421            P03956                  x
                                                                                                                                                                                                                      E tracellular m      atrix                                                            es
                                                                                                                                                                                                                                                        Interstitial collagenase, cleav collagens (ty I, II, III, V andX                  pe             II         )
m matrix etalloproteinase11(strom sin3)                  ely                  MP M 11                                 MP M 11                  18     6      17      28    NM_005940            P24347                  x
                                                                                                                                                                                                                      E tracellular m      atrix        S ely 3;inv edinphy
                                                                                                                                                                                                                                                           trom sin olv                                    siologic andpathologic processes associatedw ex                                          atrix odeling.
                                                                                                                                                                                                                                                                                                                                                                                 ith tracellular m rem
m matrix etalloproteinase12(m                      acrophageelastase) P          M
                                                                              M 12                                    MP M 12                  18     7      18      29    NM_002426            P39900                E tracellular m
                                                                                                                                                                                                                        x                  atrix        E tracellular m , degrades elastin,im
                                                                                                                                                                                                                                                           x                  atrix                                             portant intissuerem         odelingandrepair duringdev              ent          m
                                                                                                                                                                                                                                                                                                                                                                                             elopm andinflam ation
m matrix etalloproteinase13(collagenase3) M P                                    M 13                                 MP M 13                  18     8      19      30 NM_002427               P45452                  x
                                                                                                                                                                                                                      E tracellular m      atrix        C  ollagenase3; degrades fibrillar collagens
m matrix etalloproteinase14(m brane-inserted) M 14 em                        MP                                      MP M 14                   18     9      20      31 NM_004995               P50281                  x
                                                                                                                                                                                                                      E tracellular m      atrix                    em
                                                                                                                                                                                                                                                        Transm branem m              atrix etalloprotease14; activ thecollagenasegelatinaseA ates
m matrix etalloproteinase15(m brane-inserted)M P   em                            M 15                                 MP M 15                  18    10      21      32 NM_002428               P51511                  x
                                                                                                                                                                                                                      E tracellular m      atrix                    em
                                                                                                                                                                                                                                                        Transm branem m              atrix etalloprotease15; activ thecollagenasegelatinaseA ates
m m                                                              , D MP
   atrix etalloproteinase2(gelatinaseA 72k agelatinase, 72k aty IVcollagenase)P    M2         D pe                     M 2 M                   18    11      22      33    NM_004530            P08253                  x
                                                                                                                                                                                                                      E tracellular m      atrix        G                       pe
                                                                                                                                                                                                                                                           elatinaseA(ty IVcollagenase); degrades gelatin, ty IV V andV collagen, andfibronectin      pes , ,              II
m matrix etalloproteinase3(strom sin1, progelatinase)  ely                     MP  M3                                  MP  M3                  19     1      12      23    NM_002422            P08254                  x
                                                                                                                                                                                                                      E tracellular m      atrix        E tracellular m , degrades fibronectin, collagens
                                                                                                                                                                                                                                                           x                  atrix
m matrix etalloproteinase7(m sin, uterine) M P   atrily                            M7                                  MP  M7                  19     2      13      24    NM_002423            P09237                  x
                                                                                                                                                                                                                      E tracellular m      atrix           atrily
                                                                                                                                                                                                                                                        M sin7;ex            pressedduringthem                         igrationproliferationphase
m matrix etalloproteinase8(neutrophil collagenase)M 8                          MP                                      MP  M8                  19     4      15      26 NM_002424               P22894                ex  tracellular m    atrix        m  etalloendopeptidaseactiv                     ity
   et
m proto-oncogene(hepatocy grow factor receptor)   te th                         MT  E                                   MT  E                  19     5      16      27       J02958            P08581                            th
                                                                                                                                                                                                                           grow factor                  protein-ty    rosinek     inaseactiv            ity
   alate drogenase1
M dehy                                                                          MH  D                                  MH  D1                  19     6      17      28    NM_005917            P24347               H  ouseK     eepinggene            H  ouseK    eepinggene
m                                      th
   etallothionein3(grow inhibitoryfactor (neurotrophic))                         M   T3                                  M  T3                 19     7      18      29    NM_005954            P25713                  cell proliferation                     y etal
                                                                                                                                                                                                                                                        heav m binding
m  icrotubule-associatedprotein, R /E fam , mAber 1     P B ily M P E         emR                                       AR1
                                                                                                                     MP E                      19     8      19      30    NM_012325            Q15691                       cell cy   cle              m  icrotubulebinding
m                     ated
   itogen-activ proteink                     inase10                         M P 10
                                                                                AK                                      AK
                                                                                                                     M P 10                    20     2      13      24    NM_002753            P53779                  stress response                 proteinserine/threoninek                    inaseactiv            ity
m                     ated
   itogen-activ proteink                     inase12                         M P 12
                                                                                AK                                      AK
                                                                                                                     M P 12                    20     3      14      25    NM_002969            P53778                  stress response                 proteinserine/threoninek                    inaseactiv            ity
m                     ated
   itogen-activ proteink                     inase14                         M P 14
                                                                                AK                                      AK
                                                                                                                     M P 14                    20     4      15      26     AF100544            Q16539                  stress response                 proteinserine/threoninek                    inaseactiv            ity
m                     ated
   itogen-activ proteink                     inase3                           MP 3
                                                                                 AK                                      AK
                                                                                                                      MP 3                     20     5      16      27       X60188            P27361                  stress response                 proteinserine/threoninek                    inaseactiv            ity
m                     ated
   itogen-activ proteink                     inase8                           MP 8
                                                                                 AK                                      AK
                                                                                                                      MP 8                     20     7      18      29       L26318            P45983                  stress response                 R  egulates c-jun, K         inase
m                     ated
   itogen-activ proteink                     inasek     inase1               MP 1
                                                                                A 2K                                    A 2K
                                                                                                                     MP 1                      20     8      19      30    NM_002755            Q02750                       C cy
                                                                                                                                                                                                                                ell cle                 K               ataly es
                                                                                                                                                                                                                                                           inase; C z thephosphory                                                                  r
                                                                                                                                                                                                                                                                                                                    lationof athr andaty inathr-glu-ty                r
m                     ated
   itogen-activ proteink                     inasek     inase5                  A 2K
                                                                             MP 5                                       A 2K
                                                                                                                     MP 5                      20     9      20      31     BT006780            Q13163                  stress response                 proteinserine/threoninek                    inaseactiv            ity
m                     ated
   itogen-activ proteink                     inasek     inase6                  A 2K
                                                                             MP 6                                       A 2K
                                                                                                                     MP 6                      20    10      21      32    NM_002758            P52564                  stress response                 proteinserine/threoninek                    inaseactiv            ity
m                     ated
   itogen-activ proteink                     inasek     inasek    inase14 P 14
                                                                            M 3K
                                                                               A                                       A 3K
                                                                                                                    M P 14                     21     1      12      23    NM_003954            Q99558                  stress response                 proteinserine/threoninek                    inaseactiv            ity
   y                         em
meloidcell leuk iasequence1(B L2-related) M L1              C                      C                                       C
                                                                                                                        M L1                   21     2      13      24     AF118124            Q07820                       apoptosis                  apoptosis regulator activ                 ity
   y                        e em irus
meloproliferativ leuk iav oncogene                                               ML  P                                   ML P                  21     3      14      25    NM_005373            P40238                  cell proliferation              hem    atopoietin/interferon-class (D                        200-dom cy inereceptor activ
                                                                                                                                                                                                                                                                                                                                   ain) tok                            ity
       e th
nerv grow factor receptor (TN Rsuperfam , m G R16)   F                 ily N F  em    ber                              NF  GR                  21     4      15      26      M14764             Q00994                ell
                                                                                                                                                                                                                    C signaling/receptor                receptor
neural cell adhesionm                  olecule1                               NA1CM                                   NA1CM                    21     5      16      27    NM_181351            P13591                    cell adhesion                 cell adhesionm           oleculeactiv              ity
neuregulin1                                                                    NG  R1                                  NG  R1                  21     6      17      28      M94165             Q02297                   ell
                                                                                                                                                                                                                      C differentiation                 E           al
                                                                                                                                                                                                                                                           piderm differentiation
                    in
neurofibrom 2(bilateral acoustic neurom                             a)           N2  F                                   N2 F                  21     7      18      29       L11353            P35240                         tosk
                                                                                                                                                                                                                           cy eleton                    structural m      oleculeactiv            ity
neurotrophic ty          rosinek     inase, receptor, ty 1 N K   pe              TR 1                                 N KTR 1                  21     8      19      30    NM_002529            P04629                     oncogenesis                  proteink     inaseactiv        ity
neurotrophin3                                                                   N 3TF                                   N 3TF                  21     9      20      31    NM_002527            P20783                            th
                                                                                                                                                                                                                          grow factor                          th
                                                                                                                                                                                                                                                        grow factor activ           ity
nidogen(enactin)                                                                 N   ID                                   N  ID                21    10      21      32    NM_002508            P14543                    cell adhesion                 cell adhesionm           oleculeactiv              ity
ninjurin1                                                                      N J1IN                                  N J1IN                  21    11      22      33      U91512             Q92982                    cell adhesion                 hom    ophilic cell adhesionm                   olecule
   -6-m lguanine-D Am ltransferase
O ethy                             N ethy                                      MM  GT                                  MM  GT                  22     2      13      24    NM_002412            P16455                N
                                                                                                                                                                                                                    D Arepair / sy        nthesis       R of alk latedguanineinD Abystoichiom
                                                                                                                                                                                                                                                           epair           y                                      N                         etricallytransferringthealk l groupat theo-6positiontoacy
                                                                                                                                                                                                                                                                                                                                                                              y                                 steineresidue
opioidbindingprotein/cell adhesionm                                           eP M
                                                               olecule-likO C L                                          PM
                                                                                                                      OC L                     22     3      14      25    NM_002545            Q14982                    cell adhesion                 opioidreceptor activ             ity
p21(C K 1A  D N )-activ k         ated inase2                                  PK A2                                   PK  A2                  22     4      15      26    NM_002577            Q13177                  stress response                 proteinserine/threoninek                    inaseactiv            ity
pax   illin                                                                     PN  X                                   PN  X                  22     5      16      27    NM_002859            P49023              tosk
                                                                                                                                                                                                                 cy eleton/cell adhesion                proteinbinding
   C IR
P TA Eproteink                   inase1                                          C 1
                                                                              P TK                                       C 1
                                                                                                                      P TK                     22     6      17      28     BT006827            Q00536                  stress response                 proteinserine/threoninek                    inaseactiv            ity
   DF
P G Aassociatedprotein1                                                       PA1DP                                   PA1DP                    22     7      18      29 NM_014891               Q13442                  cell proliferation              signal transduction
phosphodiesterase1B calm              ,         odulin-dependent P E             D 1B                                 PE D 1B                  22     8      19      30 NM_000924               Q01064                       apoptosis                  calm    odulin-dependent cy                clic-nucleotidephosphodiesteraseactiv                           ity
phospholipaseD phophatidy    1,                    lcholine-specific P 1           LD                                   P 1LD                  22     9      20      31    NM_002662            Q13393            phospholipidm         etabolism       phospholipaseDactiv                  ity
placental grow factor, v th               ascular endothelial grow P F         thfactor-relatedprotein
                                                                                     G                                   PF G                  22    10      21      32    NM_002632            P49763                            th
                                                                                                                                                                                                                          grow factor                          th
                                                                                                                                                                                                                                                        grow factor activ           ity
plasm      inogen                                                                P   LG                                  P  LG                 23     1      12      23    NM_000301            P00747                       N
                                                                                                                                                                                                                           D Abinding                            bin ity
                                                                                                                                                                                                                                                        throm activ
plasm                          ator
           inogenactiv inhibitor, ty 1                 pe                  S R IN 1
                                                                              EP E                                    EP E
                                                                                                                   S R IN 1                    23     2      13      24      M14083             P05121                      C  irculation                  erine
                                                                                                                                                                                                                                                        S (or cy           steine) proteinaseinhibitor; R                          egulates fibrinoly     sis
plasm      inogenactiv tissue  ator,                                           P T LA                                  P T LA                  23     3      14      25    NM_000930            P00750                      C  irculation               serineproteasethat conv inactiv plasm       erts                  e           inogentoplasm         in
plasm      inogenactiv urok    ator, inase                                     P U LA                                  P U LA                  23     4      15      26    NM_002658            P00749                      C  irculation               S proteasethat cleav plasm
                                                                                                                                                                                                                                                           erine                                     es                 inogentoformplasm              in
plasm      inogenactiv urok    ator, inasereceptor                            P ULA R                                 P ULA R                  23     5      16      27    NM_002659            Q03405               ell
                                                                                                                                                                                                                   C signaling/ receptor                K mey oleculeintheregulationof cell-surfaceplasm                                         inogenactiv     ation
                      ed th
platelet-deriv grow factor alphapoly                            peptide P G A    DF                                      DF
                                                                                                                      P GA                     23     6      17      28       X06374            P04085                           th
                                                                                                                                                                                                                          grow factor                   potent m     itogen
                      ed th
platelet-deriv grow factor betapoly                                           Pian B a iral -sis)
                                                                                 DF
                                                              peptide(sim Gsarcom v (v oncogenehomB                   P Golog)
                                                                                                                         DF                    23     7      18      29    NM_002608            P01127          ell        th
                                                                                                                                                                                                              C grow and/or m              aintenance   M  utations inthis geneareassociatedw m                                 ith eningiom        a
                      ed th
platelet-deriv grow factor receptor, alphapoly D F A                          peptide
                                                                            P GR                                     P GR
                                                                                                                        DFA                    23     8      19      30    NM_006206            P16234                            th
                                                                                                                                                                                                                           grow factor                  transm branereceptor proteinty
                                                                                                                                                                                                                                                                   em                                                rosinek      inaseactiv      ity
P  hospholipaseA              2                                                 P 2LA                                   WA
                                                                                                                      Y HZ                     23     9      20      31      M86400             P04054               H  ouseK     eepinggene            H  ouseK    eepinggene
pleiotrophin(heparinbindinggrow factor 8, neuritegrow   th                          TN         oting
                                                                                P th-prom factor 1)                     P   TN                 23    10      21      32 NM_002825               P21246             cle
                                                                                                                                                                                                           cell cy regulationandproliferation           proteinphosphataseinhibitor av ity                         tiv
       m                N
poly erase(D Adirected), alpha                                                P LA
                                                                                 O 2                                     O 2
                                                                                                                      P LA                     23    11      22      33    NM_002689            Q14181                N
                                                                                                                                                                                                                    D Arepair / sy        nthesis       D Apoly erase
                                                                                                                                                                                                                                                           N          m
prefoldin5                                                                    PD5FN                                   PD5FN                    24     2      13      24      D89667             Q99471                transcriptionfactor               transcriptionco-repressor activ                        ity
              m
program edcell death2                                                         PC2DD                                   PC2DD                    24     3      14      25       S78085            Q16342                       apoptosis                     N
                                                                                                                                                                                                                                                        D Abinding
proliferatingcell nuclear antigen                                              PN  CA                                  PN  CA                  24     4      15      26    NM_002592            P12004                          ell cle
                                                                                                                                                                                                                             C cy                                                     m
                                                                                                                                                                                                                                                        increasingthepoly erase's processibility
prolinedehy          drogenase(ox           idase) 1                          P OH
                                                                                RD                                      RD
                                                                                                                      P OH                     24     5      16      27    NM_016335            O43272                prolinem       etabolism          prolinedehy        drogenaseactiv                ity
pro-platelet basic protein(chem ine(C -Cm P B 7)     ok         -X otif) ligand   PP                                   PB  PP                  24     7      18      29    NM_002704            P02775                ex  tracellular m    atrix        ex                    atrix
                                                                                                                                                                                                                                                            tracellular m structural constituent
prostaglandinEsy                nthase                                          TG S
                                                                              P E                                       TG S
                                                                                                                      P E                      24     8      19      30     AF010316            O14684                       apoptosis                  prostaglandinm           etabolism
protein(peptidy                    l
                          l-proly cis/trans isom            erase) N A U L5 1
                                                                        IM -interacting
                                                                                   B                                       B
                                                                                                                        U L5                   24     9      20      31 NM_006221              Q9Y5K5                       cell cy   cle               m  olecular functionunk              now
proteink                     N -activ
              inase, D A ated, cataly poly P K C            tic peptide D       R                                       RD
                                                                                                                      PKC                      24    10      21      32 NM_006904               P78527                proteinm      odification         inositol/phosphatidy             linositol k         inaseactiv          ity
protocadherin1(cadherin-lik 1)                 e                              PD1CH                                   PD1CH                    25     1      12      23 L11369                  Q08174                      ossification                calciumionbinding
   TK
P 2proteinty               rosinek      inase2                                 P 2 TK                                  P 2 TK                  25     2      13      24       L13616            Q05397                      cell grow    th             protein-ty    rosinek     inaseactiv            ity
                            ent
purine-richelem bindingproteinA                                                PR  UA                                  PR  UA                  25     4      15      26    NM_005859            Q00577           N
                                                                                                                                                                                                               D Areplication/ transcription            single-strandedD Abinding  N
quiescinQ          6                                                             SN
                                                                              QC 6                                       SN
                                                                                                                      QC 6                     25     5      16      27    NM_002826               /                        cell grow    th             electrontransporter activ                 ity
R  ibosom P    al roteineS           9                                            S   9                                RS  P9                  25     6      17      28    NM_001013            P46781               H  ouseK     eepinggene            H  ouseK    eepinggene
              olog
ras hom genefam , m ber A            ily em                                    AH  RA                                  AH  RA                  25     7      18      29 NM_001664               P61586                       cell cy   cle                 ho all onom TP
                                                                                                                                                                                                                                                        R sm m eric G aseactiv                                            ity
R  as-relatedassociatedw diabetes          ith                                 RA  RD                                  RA  RD                  25     8      19      30    NM_004165            P55042                       TP
                                                                                                                                                                                                                           G binding                         all onom TP
                                                                                                                                                                                                                                                        sm m eric G aseactiv                                     ity
R  ibonucleotidereductaseM peptide             1                               RM  R1                                  RM  R1                  25    10      21      32    NM_001033            P23921                N
                                                                                                                                                                                                                    D Arepair / sy        nthesis       R  ibonucleotidereductaseessential for theproductionof desox ribonucleotides beforeD Asy                y                           N nthesis inSphase
receptor (TN R F     F S )-interactingserine-threoninek R K                       IP
                                                                             inase1                                    RK IP 1                 25    11      22      33 NM_003804               Q13546                  stress response                 proteinserine/threoninek                    inaseactiv            ity
replicationfactor C(activ 1) 2, 40k a     ator                D                 RC F2                                   RC F2                  26     1      12      23    NM_002914            P35250                       cell cy   cle              nucleotidebinding
ret proto-oncogene(m                ultipleendocrineneoplasiaandm                   E              roid
                                                                                R T edullarythy carcinom 1, HE   a RT      irschsprungdisease) 26     2      13      24 NM_000323              Q95M86                     O  ncogenesis                    m ogenesis , O
                                                                                                                                                                                                                                                        E bry                        ncogene
                       a
retinoblastom 1(includingosteosarcom                              a)             R1  B                                   R1 B                  26     3      14      25    NM_000321            P06400                          ell cle
                                                                                                                                                                                                                             C cy                                        ith                                 lase
                                                                                                                                                                                                                                                        Interacts w histonedeacety torepress transcription; tum repressor                                       or
                       a
retinoblastom bindingprotein1                                                  RP  B1                                  RP  B1                  26     4      15      26    NM_002899            P29374               N
                                                                                                                                                                                                                   D Abinding/ cell cy          cle               atin
                                                                                                                                                                                                                                                        chrom binding
                       a
retinoblastom bindingprotein2                                                  RP  B2                                  RP  B2                  26     5      16      27 NM_004164               P29375                transcriptionfactor               transcriptionfactor
retinoic acidreceptor, alpha                                                   RR  AA                                  RR  AA                  26     6      17      28    NM_000964            P10276                    Transcription                    tim
                                                                                                                                                                                                                                                        S ulates transcriptioninaligand-dependent m                                          anner
   ho D
R G Pdissociationinhibitor (G I) alpha A H D            D                      R G IA                               AHDR G IA                  26     7      18      29    NM_004309            P52565                       cell cy   cle                 ho D -dissociationinhibitor activ
                                                                                                                                                                                                                                                        R GP                                                               ity
   ho TP
R G aseactiv protein1          ating                                       AHA1R GP                                    R GP
                                                                                                                    AHA1                       26     8      19      30    NM_004308            Q07960                       cell cy   cle                 ho TP
                                                                                                                                                                                                                                                        R G aseactiv activ           ator ity
R  ho-associated, coiled-coil containingproteink R C1                            O 1
                                                                            inaseK                                    RC1OK                    26     9      20      31    NM_005406            Q13464                  stress response                 proteinserine/threoninek                    inaseactiv            ity
                     z
secretedfriz led-relatedprotein2                                              SR2FP                                   SR2FP                    26    10      21      32     AF311912               /              ignal
                                                                                                                                                                                                                S transduction/receptor                            em
                                                                                                                                                                                                                                                        transm branereceptor activ                          ity
secretedprotein, acidic, cy                   steine-rich(osteonectin)A C       P
                                                                              S R                                       PR
                                                                                                                      SAC                      26    11      22      33    NM_003118            P09486                  x
                                                                                                                                                                                                                      E tracellular m      atrix        calciumionbinding
                                              ator
signal transducer andactiv of transcription1,S D                                 TAa
                                                                               91k T1                                 S T1
                                                                                                                         TA                    27     2      13      24    NM_007315            P42224           R egulationof transcription            S transduction, intracellular signalingcascade, hem
                                                                                                                                                                                                                                                           ignal                                                                                        atopoietin/interferon-class (D             ain) tok
                                                                                                                                                                                                                                                                                                                                                                                          200-dom cy inereceptor signal transducer, transcriptionfactor
   erine ehy
S D dratase                                                                     SS  D                                   SS  D                  27     3      14      25    NM_006843            P17026               H  ouseK     eepinggene            H  ouseK    eepinggene
superox dism ide utase1, soluble(amotrophic lateralD        y                      O1
                                                                               S sclerosis 1(adult))                   SD  O1                  27     4      15      26    NM_000454            P00441                transcriptionfactor               transcriptionfactor activ                ity
              m a asionandm
T-cell ly phom inv                                    etastasis 1 TIA 1               M                                TIA 1  M                27     5      16      27    NM_003253            Q13009                  stress response                 copper
TE ty K rosinek          inase, endothelial (v            enous m    alformTE m       K
                                                                                ations, ultiplecutaneous andm TE    ucosal)   K                27     7      18      29    NM_000459            Q969V4                   proteinbinding                 receptor signalingproteinactiv                         ity
telom                    erse
          erase-rev transcriptase                                              TE T   R                                TE T   R                27     8      19      30     AF018167            O14746                N
                                                                                                                                                                                                                    D Arepair / sy        nthesis       D Apoly erase,predictedtoact as rev transcriptase;m hav aroleinform of telom
                                                                                                                                                                                                                                                           N          m                                                        erse                         ay e                     ation         eres
tenascinC(hex              abrachion)                                           TN    C                                 TN    C                27     9      20      31    NM_002160            P24821                    cell adhesion                 cell adhesionm           oleculeactiv              ity
throm     bospondin1                                                          TH S   B1                               TH S   B1                27    10      21      32    NM_003246            P07996                      ell
                                                                                                                                                                                                                          C adhesion                    A           e coprotein;potent angiogenic activ
                                                                                                                                                                                                                                                           dhesiv gly                                                                    ity
     roid
thy autoantigen70k a(K antigen)        D u                                     G 122P                                  G 122P                  28     1      12      23       S38729            P12956                     m
                                                                                                                                                                                                                       Im uneresponse                      ole                                   N
                                                                                                                                                                                                                                                        R for theantigeninD Arepair or transposition
tissueinhibitor of m              etalloproteinase2                           TIM 2  P                                TIM 2  P                 28     2      13      24    NM_003255            P16035                  x
                                                                                                                                                                                                                      E tracellular m      atrix                        M 2, olv
                                                                                                                                                                                                                                                        Inhibits M P inv edinhom                              eostasis of theex              tracellular m   atrix
      F
TN receptor-associatedfactor 2                                                TR F   A2                               TR F   A2                28     3      14      25    NM_021138            Q12933                signal transduction               signal transducer activ               ity
      F S 1A
TN R F -associatedv deathdom              ia                  ain             TR D  AD                                TR D  AD                 28     4      15      26    NM_003789            Q15628                       apoptosis                  inductionof apoptosis
topoisom        erase(D A I   N)                                               TO 1   P                                TO 1   P                28     5      16      27    NM_003286            P11387                      cell grow    th                N
                                                                                                                                                                                                                                                        D Abinding
      A ily em
TR Ffam m ber-associatedN K activ TA K                    F B ator N                                                   TA K   N                28     6      17      28      U59863             Q92844                signal transduction               proteinbinding
      A
TR Finteractingprotein                                                          TR    IP                                TR    IP               28     7      18      29    NM_005879           Q8WXE1                        apoptosis                  inductionof apoptosis
transcriptionfactor D              p-1                                        TF P  D1                                TF P  D1                 28     8      19      30    NM_007111            Q00765                    Transcription                 M  ediator of transcriptional activ byTG -betareceptor;inv edinthecell cy ; P II transcription
                                                                                                                                                                                                                                                                                                                ation               F                        olv                   cle ol
                ing th
transform grow factor, alpha                                                   TG A   F                                TG A   F                28     9      20      31 NM_003236               P01135            row
                                                                                                                                                                                                                G thfactors andcy ines        tok          row
                                                                                                                                                                                                                                                        G thfactor , Transferase
                ing th
transform grow factor, beta1                                                  TG B   F1                               TG B   F1                28    10      21      32 NM_000660               Q8IXP8             row
                                                                                                                                                                                                                 G thfactor andcy ines       tok        anti-apoptotic
                ing th
transform grow factor, beta2                                                  TG B   F2                               TG B   F2                28    11      22      33      M19154             P61812                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok                      ing th
                                                                                                                                                                                                                                                        transform grow factor-betareceptor binding
                ing th
transform grow factor, beta3                                                  TG B   F3                               TG B   F3                29     1      12      23    NM_003239            P10600                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok                      ing th
                                                                                                                                                                                                                                                        transform grow factor-betareceptor binding
                ing th
transform grow factor, betareceptor I                                        TG B 1 FR                               TG B 1 FR                 29     2      13      24    NM_004612            P36897                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok        receptor activ      ity
                ing th
transform grow factor, betareceptor II                                       TG B 2 FR                               TG B 2 FR                 29     4      15      26      D50683             P37173                         or
                                                                                                                                                                                                                       Tum supressor                           or
                                                                                                                                                                                                                                                        Tum supressor, receptor;roleinthesignal transductionthat leads tom                                                 itogenic responses
                ing th
transform grow factor, betareceptor III (betaglyF R D                             can, 300k
                                                                             TG B 3 a)                               TG B 3 FR                 29     5      16      27    NM_003243            Q03167                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok        receptor activ      ity
Transferrinreceptor                                                              TF   R                                TF C  R                 29     6      17      28    NM_003234            P02786               H  ouseK     eepinggene            H  ouseK    eepinggene
            em
transm branetraffick protein          ing                                     TM 21  P                                TM 21  P                 29     7      18      29    NM_006827            P49755                        transport                 v esicletargeting
trophoblast gly          coprotein                                             TP G   B                                TP G   B                29     8      19      30    NM_006670               /                      cell adhesion                 proteogly     can
      or
tum necrosis factor (ligand) superfam , m berF F               ily em 11 11 TN S                                          FF
                                                                                                                    TN S 11                    29    10      21      32 AF053712                O14788                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok              or
                                                                                                                                                                                                                                                        tum necrosis factor receptor binding
      or
tum necrosis factor (ligand) superfam , m ber 5S 5             ily emTN (hy         F Fper-IgMsy ndrom  e)           TN S 5 FF                 29    11      22      33    NM_000639            P29965           grow factor andcy ine
                                                                                                                                                                                                                        th                   tok              or
                                                                                                                                                                                                                                                        tum necrosis factor receptor binding
      or
tum necrosis factor (ligand) superfam , m ber 6S 6             ily emTN F           F                                TN S 6 FF                 30     1      12      23    NM_000639            P48023                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok              or
                                                                                                                                                                                                                                                        tum necrosis factor receptor binding
      or
tum necrosis factor receptor superfam , m TN R F                            ber S
                                                                ily em F1A 1A                                           F S 1A
                                                                                                                   TN R F                      30     2      13      24    NM_001065            P19438                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok        receptor activ      ity
      or
tum necrosis factor receptor superfam , m TN5S 5                ily em F F  ber R                                   TN R FF S5                 30     3      14      25    NM_152854            P25942                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok                   em
                                                                                                                                                                                                                                                        transm branereceptor activ                          ity
      or
tum necrosis factor receptor superfam , m TN6S 6                ily em F F  ber R                                   TN R FF S6                 30     4      15      26    NM_000043            P25445                  th
                                                                                                                                                                                                                 grow factor andcy ine       tok                   em
                                                                                                                                                                                                                                                        transm branereceptor activ                          ity
      or
tum proteinp53(Li-F eni sy           raum ndrom                 e)              TP    53                                TP    53               30     5      16      27     AF307851            P04637                          ell cle
                                                                                                                                                                                                                             C cy                       DA N -bindingprotein; tum suppressor activ or                                 ity
      or
tum proteinp73                                                                  TP    73                                TP    73               30     6      17      28    NM_005427            O15350                transcriptionfactor               transcriptionfactor activ                ity
      R3
TY O proteinty               rosinek      inase                               TY O   R3                               TY O   R3                30     7      18      29    NM_006293            Q06418          signal transduction/ receptor           transm branereceptor proteinty
                                                                                                                                                                                                                                                                   em                                                rosinek      inaseactiv      ity
ty rosinek                   ith m
                inasew im unoglobulinandepiderm TIE thfactor hom dom           al grow                ology ains TIE                           30     8      19      30    NM_005424            P35590          signal transduction/ receptor                      em
                                                                                                                                                                                                                                                        transm branereceptor proteinty                               rosinek      inaseactiv      ity
       m late nthetase
Thy idy sy                                                                     TY S   M                                TY S   M                30     9      20      31    NM_001071            P04818                         N
                                                                                                                                                                                                                            D Arepair                        m late nthaseactiv
                                                                                                                                                                                                                                                        thy idy sy                                   ity
ubiquitin-conjugatingenz m E (R D hom U E  y e 2A A 6 olog) 2A                   B                                    UE B 2A                  31     2      13      24      M74524             P49459                         N
                                                                                                                                                                                                                            D Arepair                   ubiquitinconjugatingenz m activ             y e ity
  -ak urine m a iral
v t m thy om v oncogenehom 1 A T1                                  olog K                                              A T1K                   31     3      14      25    NM_005163            P31749                       apoptosis                  receptor signalingproteinserine/threoninek                                    inaseactiv     ity
v                                          th
  ascular endothelial grow factor receptor 3                                    F  LT4                                  F  LT4                 31     4      15      26 NM_002020               P35916               ell
                                                                                                                                                                                                                   C signaling/ receptor                E  ndothelial cell-specific receptor;regulatorof bloodv                                  essel dev            ent       bry
                                                                                                                                                                                                                                                                                                                                                              elopm inem os andangiogenesis inadults tissus
v -erb-aery                                em iral
                 throblastic leuk iav oncogenehom B 4(av                         olog
                                                                                 R
                                                                              E B ian)                                EB4RB                    31     5      16      27 NM_005235               Q15303                  cell proliferation              receptor activ      ity
  -fos B urine
v F J m osteosarcom v oncogenehom S                a iral                        F  O
                                                                                    olog                                 FS O                  31     7      18      29    NM_005252            P01100                    O  ncogenesis                 R  egulator of cell proliferationdestinedtoformandm                                       aintainthesk      eleton; O ncogene
  illin rin)
v 2(ez                                                                          V   IL2                                 V   IL2                31     8      19      30    NM_003379            P15311                      cell m   otility                tosk
                                                                                                                                                                                                                                                        cy eleton
  im
v entin                                                                          V   IM                                   V  IM                31     9      20      31    NM_003380            P08670                    angiogenesis                  Interm                     ent
                                                                                                                                                                                                                                                                  ediatefilam protein
v itronectin(serumspreadingfactor, som edinBTN plem S                               ,
                                                                 atom V com ent -protein)                               V   TN                 31    10      21      32 NM_000638               P04004                    cell adhesion                 cell adhesionm           oleculeactiv              ity
  -mc y tom                                iral
v y melocy atosis v relatedoncogene, neuroblastom deriv (av                    MC  Y N a ed ian)                       MC  YN                  32     3      14      25 NM_005378               P04198                transcriptionfactor               transcriptionfactor activ                ity
  -raf urine
v m sarcom v oncogenehom B R F    a iral                          olog 1B A                                            BA  RF                  32     4      15      26 NM_004333               P15056                  stress response                 proteinserine/threoninek                    inaseactiv            ity
  -src
v sarcom (S idt-R    a chm uppinA v oncogeneR olog(av  -2) iral                 Shom  C       ian)                      SC  R                  32     5      16      27    NM_198291            P12931                      cell grow    th             protein-ty    rosinek     inaseactiv            ity
w                  pe M
   ingless-ty M TVintegrationsitefam m berN                      ily em W T2        2                                  W T2N                   32     6      17      28    NM_003391            P09544           dev            ental
                                                                                                                                                                                                                      elopm processes                   signal transducer activ               ity
Gene Name                          Row        Comments
*y                                            *hybr

DualChip™ human cancer version 1.0

Gene Name                            Row         Col 1        Col 2     Col 3                                                       Comments
Gene Name                          Row        Col 1        Col 2        Col 3   Comments
Positive hybridization control 1         1            1            12    23                                         Silverquant® or Fluorescence detection control
Negative detection control 1             1            2            13    24                                                   Unspecific detection control
Negative detection control 2             2            1            12    23                                                   Unspecific detection control
Negative detection control 3             2            6            17    28                                                   Unspecific detection control
Negative detection control 4             2            11           22    33                                                   Unspecific detection control
Internal Standard 4 - 1                  3            3            14    25            Labeling reaction and hybridization control / normalization control / 30 pg for 2 µl of internal standard mix
Internal Standard 3 - 1                  3            9            20    31           Labeling reaction and hybridization control / normalization control / 100 pg for 2 µl of internal standard mix
Negative hybridization control 1         5            1            12    23                                                 Unspecific hybridization control
Negative detection control 5             5            6            17    28                                                   Unspecific detection control
Internal Standard 5 - 1                  8            3            14    25            Labeling reaction and hybridization control / normalization control / 10 pg for 2 µl of internal standard mix
Internal Standard 1 - 1                  8            9            20    31         Labeling reaction and hybridization control / normalization control / 10000 pg for 2 µl of internal standard mix
Negative detection control 6             8            10           21    32                                                   Unspecific detection control
Negative detection control 7             8            11           22    33                                                   Unspecific detection control
Negative detection control 8             9            1            12    23                                                   Unspecific detection control
Negative detection control 9             9            6            17    28                                                   Unspecific detection control
Negative detection control 10            9            11           22    33                                                   Unspecific detection control
Negative detection control 11            11           1            12    23                                                   Unspecific detection control
Negative hybridization control 2         11           11           22    33                                                 Unspecific hybridization control
Negative detection control 12            13           1            12    23                                                   Unspecific detection control
Negative detection control 13            13           6            17    28                                                   Unspecific detection control
Negative detection control 14            13           11           22    33                                                   Unspecific detection control
Internal Standard 2 - 1                  14           3            14    25          Labeling reaction and hybridization control / normalization control / 1000 pg for 2 µl of internal standard mix
Internal Standard 6 - 1                  14           9            20    31             Labeling reaction and hybridization control / normalization control / 5 pg for 2 µl of internal standard mix
Negative hybridization control 3         16           1            12    23                                                 Unspecific hybridization control
Negative detection control 15            16           6            17    28                                                   Unspecific detection control
Negative detection control 16            16           11           22    33                                                   Unspecific detection control
Negative detection control 17            17           9            20    31                                                   Unspecific detection control
Internal Standard 3 - 2                  19           3            14    25           Labeling reaction and hybridization control / normalization control / 100 pg for 2 µl of internal standard mix
Internal Standard 6 - 2                  19           9            20    31             Labeling reaction and hybridization control / normalization control / 5 pg for 2 µl of internal standard mix
Negative detection control 18            19           10           21    32                                                   Unspecific detection control
Negative detection control 19            19           11           22    33                                                   Unspecific detection control
Negative detection control 20            20           1            12    23                                                   Unspecific detection control
Negative detection control 21            20           6            17    28                                                   Unspecific detection control
Negative detection control 22            20           11           22    33                                                   Unspecific detection control
Negative detection control 23            22           1            12    23                                                   Unspecific detection control
Negative hybridization control 4         22           11           22    33                                                 Unspecific hybridization control
Negative detection control 24            24           1            12    23                                                   Unspecific detection control
Negative detection control 25            24           6            17    28                                                   Unspecific detection control
Negative detection control 26            24           11           22    33                                                   Unspecific detection control
Internal Standard 2 - 2                  25           3            14    25          Labeling reaction and hybridization control / normalization control / 1000 pg for 2 µl of internal standard mix
Internal Standard 5 - 2                  25           9            20    31            Labeling reaction and hybridization control / normalization control / 10 pg for 2 µl of internal standard mix
Negative hybridization control 5         27           1            12    23                                                 Unspecific hybridization control
Negative detection control 27            27           6            17    28                                                   Unspecific detection control
Negative detection control 28            27           11           22    33                                                   Unspecific detection control
Internal Standard 1 - 2                  29           3            14    25         Labeling reaction and hybridization control / normalization control / 10000 pg for 2 µl of internal standard mix
Internal Standard 4 - 2                  29           9            20    31            Labeling reaction and hybridization control / normalization control / 30 pg for 2 µl of internal standard mix
Negative detection control 29            30           10           21    32                                                   Unspecific detection control
Negative detection control 30            30           11           22    33                                                   Unspecific detection control
Negative detection control 31            31           1            12    23                                                   Unspecific detection control
Negative detection control 32            31           6            17    28                                                   Unspecific detection control
Negative detection control 33            31           11           22    33                                                   Unspecific detection control
Positive hybridization control 2         32           1            12    23                                         Silverquant® or Fluorescence detection control
Negative detection control 34            32           2            13    24                                                   Unspecific detection control
Negative detection control 35            32           7            18    29                                                   Unspecific detection control
Negative detection control 36            32           8            19    30                                                   Unspecific detection control
Negative detection control 37            32           9            20    31                                                   Unspecific detection control
Detection curve concentration 1          32           10           21    32                                Spotted concentration 1:3000 / only available w ith indirect labeling
Detection curve concentration 2          32           11           22    33                                Spotted concentration 1:600 / only available w ith indirect labeling
Positive hybridization control 3         33           1            12    23                                         Silverquant® or Fluorescence detection control
Negative detection control 38            33           2            13    24                                                   Unspecific detection control
Detection curve concentration 3          33           3            14    25                                Spotted concentration 1:300 / only available w ith indirect labeling
Detection curve concentration 4          33           4            15    26                                 Spotted concentration 1:60 / only available w ith indirect labeling
Detection curve concentration 5          33           5            16    27                                 Spotted concentration 1:30 / only available w ith indirect labeling
Detection curve concentration 6          33           6            17    28                                 Spotted concentration 1:12 / only available w ith indirect labeling
Detection curve concentration 7          33           7            18    29                                 Spotted concentration 1:6 / only available w ith indirect labeling
Detection curve concentration 8          33           8            19    30                                 Spotted concentration 1:3 / only available w ith indirect labeling
Detection curve concentration 9          33           9            20    31                                 Spotted concentration 1:1 / only available w ith indirect labeling
Negative detection control 39            33           10           21    32                                                   Unspecific detection control
Positive hybridization control 4         33           11           22    33                                         Silverquant® or Fluorescence detection control
DualChip™ human cancer version 1.0


                          Design




 = Gene of interest
 = Positive hybridization control / orientation control
 = Negative hybridization control
 = Negative Detection control
 = HouseKeeping gene
 = Internal Standard
                                                                  = Concentration curve of Positive Detection control




                            = Positive hybridization control
                            = Negative hybridization control
                            = Negative Detection control
                            = HouseKeeping gene
                            = Internal Standard
                            = Concentration curve of Positive Detection control

				
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