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Germ Wiki
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What was it like before

The Germ Theory of GToD?

Disease

Spontaneous generation / The Wrath of God



Herman Gordon, Ph.D. The Miasma Theory of Disease

Univ. of Arizona

The concept of contagiousness without the

concept of contagion









1 2



An Exercise in Problem Solving

What was it like before the GToD?









1546 Girolamo Fracastoro 1673 Antonie Philips van Leeuwenhoek







proposed that epidemic

disease was spread by observed microbes in a

“spores” microscope









http://en.wikipedia.org/wiki/Image:Antoni_van_Leeuwenhoek.png http://en.wikipedia.org/wiki/Image:Antoni_van_Leeuwenhoek.png







3 4

1835 Agostino Bassi 1843 Oliver Wendell Holmes



argued that disease

could be transferred

stated the Germ

between patients by

Theory of Disease for

doctors and nurses

the 1st time

who didn’t wash their

hands







http://en.wikipedia.org/wiki/Image:Antoni_van_Leeuwenhoek.png http://en.wikipedia.org/wiki/Image:Oliver_Wendell_Holmes.jpg







5 6



Described a “living entity” in the form of a contagious and visible white dust as the cause of the silk Remarkable because there was little concept of germs at this time!

epidemic in Europe. Later isolated as a fungus and named after him.



Recommended disinfection and destruction of infected silk larvae.



1845 postulated that living agents could also transmit human disease.









1847 Ignaz Semmelweiss 1849-1854 John Snow



independently

the father of

discovered the need

epidemiology, figured

for hand-washing

out that bad well

between patients, but

water caused cholera

failed to convince

–!not bad air

others







http://en.wikipedia.org/wiki/Image:Ignaz_Semmelweis.jpg http://en.wikipedia.org/wiki/Image:John_Snow.jpg







7 8

Cholera in London 1854 Filippo Pacini



isolated cholera

bacillus









http://en.wikipedia.org/wiki/Image:John_Snow.jpg







9 10



http://en.wikipedia.org/wiki/Image:Snow-cholera-map-1.jpg Also discovered the Pacinian corpuscle deep touch sensor.

Discovery of cholera bacillus was rejected because the Miasma Theory of Disease was dominant in Italy

at the time. Rediscovered by Koch 30 years later.









1860-65 Louis Pasteur(ization) Proof of Biogenesis



showed that microbes

caused fermentation



effectively advocated the

GToD, and hence became

its “father”









http://history.amedd.army.mil/booksdocs/misc/evprev/fig21.jpg http://en.wikipedia.org/wiki/Image:Coldecygne.svg





11 12



Dramatic demonstration similar to Feynman’s freezing of the rubber gasket in a glass of ice water

during the Challenger enquiry.

1867 Joseph Lister(ene) 1914 Joseph Goldberger





figured out that pellagra

Pushed anti-septics was NOT caused by

infectious agents









http://en.wikipedia.org/wiki/Image:Joseph_Lister.jpg from the CDC Public Health Image Library (PHIL #8164)





13 14









Lessons from History





History repeats itself



Truth can be rejected for stupid reasons









15


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