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					Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Baycrest Centre for Geriatric Care
Dr. Randy Mcintosh, Director of Rotman Research Institute of Baycrest Centre
Phone: (416)785 2500 xt. 3522
E-Mail: rmcintosh@rotman-baycrest.on.ca

Lead Researcher(s): Randy McIntosh
Understanding Brain Function in the "Real World" Paving the Way for Community-based
Approaches to Preventing, Managing and Rehabilitating Cognitive Impairment
People at risk of declining mental performance, particularly the elderly, face daunting quality of issues stemming from
reduced independence. Managing cognitive decline and associated health issues requires ongoing monitoring and
intervention and a self-propagating cascade of specialist visits, homecare and, ultimately, relocation to an institutional
setting. Beyond the impact on patients and their families, this reliance on resource-intensive support systems will
overwhelm our healthcare system as our population ages. It is imperative that we become better at detecting issues
before they become problematic and help patients recover from a cope with cognitive impairment in the home.

Advancements in our understanding of the brain are now permitting us to envision a future in which mobile technologies
enable early assessment of cognitive changes in the home, allowing clinicians to monitor and care for people remotely
and empowering clients with customized solutions that restore or preserve function and extend independence.

To achieve this bold vision, we must address critical gaps in our understanding of how cognitive pathways work during
everyday activities. Through its expertise in cognitive theory and neuroimaging, Baycrest has outlined the neural
networks that support cognitive functions such as memory, executive function and attention, how cognitive functions
and their underlying systems become impaired as a consequence of aging and/or neurological insult, and effective
methods for rehabilitating impaired cognition.

Baycrest is proposing to work with TRI and SMH to apply unparalleled expertise in multimodal neuroimaging and bring
neurocognitive theory into practice by studying cognitive and physical patterns in ‘real-world’ settings, This knowledge
will ultimately enable the development of monitoring technologies and rehabilitation strategies that allow diction of
changes in cognitive and neural plasticity and engender increased proficiency in everyday tasks.

This partnership brings:

•Access to at-risk population, including the elderly (Baycrest) and patients with cognitive decline at different stages of
recovery, rehabilitation and follow-up (SMH and TRI).
•A range of institutional care settings with a spectrum of imaging technologies and community networks that allow
people to be studies in a variety of environments (all).
•Stimulated environments to study people engaged in ‘real-life’ activities – including a Cave Automatic Virtual
Environment (CAVE) and a driving simulator currently under development (TRI).

Harnessing the potential of a unique translational research system that drives cognitive theory into practice requires
portable neuroimaging technology capable of gathering cognitive data in the context of routine tasks. The proponents
are requesting:

•Engineering laborator space at Baycrest with shielded space to validate mobile neuroimaging technologies, including
magnetoencephalogaphy (MEG) and eletronencephalography (EGG).
•An MEG to test cognitive function, identify markers and validate portable technologies.
•An EGG-equipped driving simulator and CAVE at SMG to assess clients who present with neurological conditions in
simulating environments.

The invest will guide the development of innovation cognitive rehab programmes and supportive technologies that will
allow people to receive the highest-quality prevention and care in the least-intensive setting – ultimately improving their
quality of life, reducing health system burden and positioning Ontario as a global leader in the advancement of brain
health.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Brock University
Ms. Carrie Kelly, Senior Research Services Coordinator
Phone: 905-688-5550 x 5024
E-Mail: ckelly@brocku.ca

Lead Researcher(s): Kimberly Cote
Cognitive Brain Research (CBR) Group
The Cognitive Brain Research (CBR) group includes four researchers from independent laboratories in Psychology at
Brock University who have overlapping interests in arousal, perception, attention, and emotion. We investigate diverse
questions from a lifespan perspective (from infancy to old age), both under normal conditions (e.g., typical
development, attention during multi-tasking) and abnormal conditions (e.g., sleep deprivation, psychopathology). We
explore the nature of individual differences and situational factors that control behaviour using EEG to quantify arousal
and attention, eye tracking to monitor perception, cognitive and behavioural tasks to assess performance, and
subjective scales to survey state and personality traits.

Equipment to be purchased:
1. EEG amplifiers, updated software, associated peripherals and computers, used for recording brain activity and other
physiological measures (e.g., heart rate) in Drs. Cote, Arnell and Segalowitz labs.
2. Software license for the 3-D camera in Dr. Mondloch’s lab to increase user access by other investigators.
3. Driving Simulator to assess driving performance in a realistic environment (e.g., driver seat and dashboard, motion,
surround-sound, and panoramic video).
4. Near-infrared spectroscopy (NIRS) to permit researchers to optically measure changes in cortical hemoglobin while a
participant performs a task. In essence, it provides information about which areas of the brain become activated when,
for example, the participant views stimuli designed to challenge specific processing systems (e.g., identifying
characteristics of faces).

Our proposal fits with Ontario’s goal to make investments in scientific excellence of benefit to Ontario in a number of
ways. We investigate diverse questions in the area of cognitive brain research that impact individuals across the
lifespan (from childhood to old age). Research on sleepiness (Dr. Cote) and attentional limitations during multi-tasking
(Dr. Arnell) has widespread applications for Health, Safety, and Quality of Life including academic performance, driving
and work safety, mental health, shift work, and healthy aging. With the benefit of the driving simulator technology, it is
our aim to work with Pharmaceutical Companies to systematically investigate the impact of sleeping pills on waking
function. We will also study the impact of sleepiness and attention on driving performance in healthy adults and patients
with sleep disorders. Our work also addresses the important area of Child and Adolescent Mental Health. Our society
incurs major costs due to anti-social and self-destructive behaviours, 75% of which begin in childhood. Dr. Segalowitz is
collaborating locally, nationally and internationally on studies of brain responses reflecting self-regulation skills to
understand mechanisms of healthy development and psychopathology. Further, the Aging Population compels our goal
of investigating both how young and older adults process facial identity and emotional expressions, and how sensitivity
to facial identity and emotional expressions changes with age. Dr. Mondloch’s 3-dimensional camera will continue to be
used to Develop Face Stimuli that have more ecological validity than any set currently available. These stimuli will be
used to investigate how perception varies across face stimuli (e.g., own- versus other-race/age) and across perceivers
(e.g., young versus older adults), as well as by others from the CBR group in research on sleepiness, attention, and
psychopathology.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Brock University
Ms. Carrie Kelly, Senior Research Services Coordinator
Phone: 905-688-5550 x 5024
E-Mail: ckelly@brocku.ca

Lead Researcher(s): Stephen S. Cheung, Glenn Tattersall
Integrated animal and human research into thermal and hypoxic stress for
countermeasures in human performance
The aim of the project and the proposed infrastructure is to create an integrated hub for environmental physiological
research at Brock University spanning both human and animal models, and enhance the building of partnerships with
industry and academic collaborators. The applicants are each internationally-renowned researchers on the
physiological effects of environmental stress, especially that from temperature and low oxygen. Cheung’s research
program is on the effects of thermal and low oxygen stress on human physiology and performance, while Tattersall has
a very broad comparative animal perspective on thermal and low oxygen stress that also transfers to human research
into neurophysiological deficits (e.g. Sudden Infant Death Syndrome). No other institution in Canada can boast proven
research excellence in such an aligned yet wide-ranging fashion. The ultimate goal of this proposal, therefore, is to
enhance the collaboration between Cheung and Tattersall, and especially to enhance the transfer of animal research to
human contexts. This is done through infrastructure that can generally be utilized for both animal and human research.

The infrastructure include: 1) a portable analyser for the amount of oxygen in human muscle and brain during rest and
exercise; 2) a thermal imaging camera for lab and field measurements of skin temperature; 3) an addition to enable low
oxygen levels in an existing animal temperature chamber; 4) monitors to enable remote temperature measurements in
humans and animals during field research; and 5) a blood analyzer to permit investigations into the effects of
environmental stress on metabolic and immunological responses in humans and animals.

Due to climate change, increased leisure time, and improved access and technology, humans are being exposed to
wider swings in temperature conditions at work (e.g. deep mining, firefighting, military), and leisure (e.g.
mountaineering, running). The aging workforce, combined with health issues from an increasingly sedentary lifestyle,
can severely impact health and safety in many occupations, making research into the effects of aging and exercise on
thermal tolerance critical. Furthermore, the promotion of physical activity as preventative medicine points to an
important need for research into the impact of thermal stress on physiological responses to exercise. Principal users
will thus include Brock collaborators with research emphases on exercise physiology in pediatric and elderly
populations.

A secondary project goal is to enhance the team’s capability to perform field research, through the selection of portable
infrastructure options (e.g. oxygen monitors, temperature monitors) where available. The enhanced portability will make
it easier to take lab-based research and validate it in field settings, or conversely to examine field observations in a
more controlled laboratory setting. Thus, this field-ready enhancement will further facilitate the team’s present (e.g.
Toronto Fire Service, Mark’s Work Wearhouse, Search & Rescue Canada) and future research collaborations with
industry. Since a particular strength of the assembled team is the development and application of non-invasive
physiological assessments, the portability and flexibility of the infrastructure will allow for the ready transfer of these
innovative techniques and approaches from the lab to the field and finally to diagnostic applications.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Brock University
Ms. Carrie Kelly, Senior Research Services Coordinator
Phone: 905-688-5550 x 5024
E-Mail: ckelly@brocku.ca

Lead Researcher(s): Vincenzo De Luca, Tomas Hudlicky
Development of biomanufacturing protocols based on plant and microbial metabolism
and available enzymes
Brock University has exceptionally talented researchers who conduct an integrated interdisciplinary research program
in Biotechnology, Green Chemistry, Plant Science and Biomedical Science. Their research focuses on coupling organic
chemical synthesis with genetically modified micro-organisms and plants to create novel products of value to human
health and well-being. Key efforts include biotransformation/green chemistry (Hudlicky), plant biotechnology (De Luca,
Deprés), bioactive lipids (Atkinson), nucleic acids and immunochemistry (Yan), and human cellular aging (Stuart). The
current proposal to upgrade the Biotechnology associated equipment infrastructure at Brock University will enable the
expansion of these collaborative research projects to develop technology and processes for biomanufacturing
pharmaceuticals, nutraceuticals, aromas, and flavours by engineered organisms (microbes, plants, yeast).

This multifaceted research has two main themes: 1) the discovery/invention of novel bioactive molecules and 2)
genome manipulation to augment specific metabolic pathways synthesizing key biomolecules or enabling key biological
activities like disease resistance. Hudlicky uses engineered microorganisms for biotransformations of cheap starting
materials into advanced chemical intermediates for the synthesis of medicinally important compounds. De Luca uses
genetic approaches to manipulate plant biosynthetic pathways for the production of medicinal compounds. Després
uses cell and molecular approaches to characterize and manipulate disease resistance pathways in plants. Atkinson
and Yan synthesize small molecules with key biological activities and Stuart evaluates these molecules as well as plant
products like resveratrol (retrieved from grape products) using human cells and rodent models. A strong synergy exists
at Brock as these groups interact and share materials, equipment, expertise, and research strategies. A particularly
exciting example is the collaboration of De Luca and Hudlicky on using plant and microbial biosynthetic pathways as
starting points for the production of pharmaceuticals, which can be evaluated locally in cell culture and rodent models
(Stuart).

The projects enabled by this infrastructure will facilitate plant engineering for biotechnological applications directly
benefiting Ontario’s high-tech economy, providing new value-added bio-manufacturing technologies. Engineering of
plants for production of molecular intermediates shortens steps in subsequent synthesis and reduces raw materials that
are increasingly difficult to acquire. Thus the cost of pharmaceuticals is reduced. This ‘green’ (in plant) synthesis
strategy also reduces the production of toxic byproducts, addressing the desire of Ontarians to reduce the
environmental footprint of manufacturing. The development of new and cleaner pharmaceutical manufacturing
processes benefits the economic and environmental well-being of Ontarians, while reducing drug costs. This research
will provide patentable new knowledge and products for international markets. It will also enable the identification and
exploitation of new phytochemicals with as yet undeveloped potential as human health therapeutics.

The research covering synthesis, isolation and analytical characterization of bioactive molecules requires a mass
spectrometer (EI, CI, FAB, GC and Autosampler); ultra-performance liquid chromatography-mass spectrometer system
with single quadrupole detector; Bruker AV300 NMR. Manipulation of biosynthetic pathways in plants requires plant
growth chambers and plant tissue culture transfer cabinets, and tools for genetic manipulation and analysis.
Characterization of synthesized molecules using human cell culture and rodent models will require animal tissue
incubators and sterile transfer cabinets, microscopes and rodent cages.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Brock University
Ms. Carrie Kelly, Senior Research Services Coordinator
Phone: 905-688-5550 x 5024
E-Mail: ckelly@brocku.ca

Lead Researcher(s): Wendy Ward, Brian Roy, David Gabriel, Deborah O’Leary,
                    Kimberley Gammage, James Mandigo
Development of Lifestyle Strategies to Promote Bone and Muscle Health Throughout the
Life Span
Developing and maintaining healthy bones and muscle, the muscle-bone unit, is a lifelong process and inextricably
linked to overall health. Aging alone predisposes to fragility fracture combined with muscle weakness and frailty.
Combined effects of the aging process and disease states can impair quality of life and functional autonomy stemming
from compromised muscle-bone function. To further develop and implement a multidisciplinary research-to-practice
approach, we are drawing on past awards with investments in the following areas that support each of the following
knowledge translation pillars:

Bench Sciences: The function and health of the muscle-bone unit are two significant factors that are inextricably linked
to overall health of the individual. Many muscle-bone unit-based diseases begin at an early age and develop with time.
Understanding of the role of the muscle-bone unit as it applies to overall physiological health and disease throughout
the life span is essential for developing lifestyle strategies that promote bone and muscle health. It is important to
examine the relationship between non- or less-invasive compounds found in blood or urine and the health of the
muscle-bone unit, first in animals (equipment for safe anaesthetization for repeated measures) and later in humans.
Discovery and high throughput instrumentation is necessary to analyze samples for these compounds.

Social Determinants of Health: There are a number of social determinants of health (e.g. behavioural, cultural,
environmental, educational) that influence success in promoting and maintaining health. It is imperative to develop
innovative strategies geared towards prevention and rehabilitation to slow progression in later years and ascertain how
these social determinants impede or facilitate bone and muscle health. Transition from bench to bed-side/community
application requires population-based assessments when testing the success of these innovative strategies. This
stream of applied research will complement the bench science investigations by examining the influence of various
social determinants of health on how nutrition (mobile nutritional monitoring devices) and physical activity (digital
monitoring technology to capture energy expenditure) may impact bone, muscle, and cardiovascular health (Doppler
ultrasound, blood metabolite analyzer) in free-living populations.

Community Engagement: We will develop a knowledge-to-action framework which incorporates knowledge users
(decision makers, policy makers, community members) in the creation and implementation of research projects. It is
important to unite, expand, and centralize our current community-based research centres (Brock University Heart
Institute; Centre for Advancement of Research in Physical Activity and Health; Centre for Healthy Development) to be
more integrated and accessible to the community. This community-based approach will allow development of relevant
research questions, projects and applicable findings that increase the implementation, feasibility, and effectiveness of
muscle-bone related interventions, policies and programs to create healthy and prosperous communities. A central
goal is to develop innovative social health marketing tools, capitalizing on technology (creation and development of
outreach methods such as mobile applications, online education, websites), and to develop “virtual community hubs”
(avenues for physically distant data collection and community involvement) to collect and disseminate interventions and
findings to stakeholders about the role of muscle-bone health with minimal cost.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Brock University
Ms. Carrie Kelly, Senior Research Services Coordinator
Phone: 905-688-5550 x 5024
E-Mail: ckelly@brocku.ca

Lead Researcher(s): Debra Inglis
Expanded fermentation and analytical testing capacity at the Cool Climate Oenology and
Viticulture Institute
This research program will enhance the sustainability of Ontario’s grape and wine industry in support of Ontario’s
varietal plan. The industry is a major player in the province’s agricultural sector, contributing approximately $1 billion
annually in benefits to the province’s economy, and employing 10,000 Ontarians. Significant growth is forecasted, with
everyone involved possessing a stake in its future, including grape growers, wineries, retailers, and the tourist industry.

However, growth and sustainability of premium wine production has its challenges, which need to be addressed in
order for the industry to reach its full potential. These challenges encompass a varied set of different yet related issues;
how to manage both current and future climatic conditions facing the region - which threaten wine grape production due
to existing winter injury and the uncertainty of how climate change will affect the best varieties to grow - as well as how
to reverse the domination of the domestic wine market by international wines, reflected in the current 43% market share
for Ontario wines.

Yet, these challenges pose unexploited opportunities, such as new product development, an increased focus on wines
at the high-quality end of the spectrum, entry of Ontario wines into new markets, and the development of a unique
identity for the industry. We have developed a diverse team of internationally recognized researchers at Brock’s Cool
Climate Oenology and Viticulture Institute (CCOVI) who are knowledgeable about the entire value chain, ranging from
grape growing, wine making, to wine business, and who have expertise in issues related to innovation,
commercialization, and sustainability. Through the ORF large infrastructure funds program along with the recently
awarded ORF RE program, we will work closely with our industry partners to find ways to adapt to climate change
events, and to develop resilient, innovative and commercially competitive products.

Ontario is implementing its varietal plan to align Ontario grape supply with demand. In support of this plan, we need to
determine the best varieties to grow in the Ontario climate for improved wine quality and sustainability of our industry, in
addition to developing signature styles for the Ontario market. This research focus requires small lot wine production
which mimics commercial production, but allows for replicated viticulture and oenological research trials to assess the
quality potential. Building on our current research winery foundation at CCOVI, a fermentation facility with individually,
temperature-regulated 50L stainless steel tanks will provide this ability. This investment, coupled with instrumentation
to assess grape and wine flavour compounds, colour complexes and antioxidant capacity of wines, will allow us to
establish an oenology database for Ontario wines, accessible by our winemakers, to assist them to improve wine
quality with the targeted characteristics consumer’s desire.

Support for this program will allow us to further build on the successes of our VQAO wine industry and become an even
more critical contributor to the province’s economy. We will achieve this by assisting our industry to produce signature
Ontario wines that are both nationally and internationally recognized, and increasing the Ontario wine market share.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Carleton University
Ms. Sandra Crocker, Associate Vice-President (Research Planning and Operations)
Phone: (613) 520-3570
E-Mail: sandra_crocker@carleton.ca

Lead Researcher(s): Lenore Fahrig
Infrastructure for Carleton-GLEL Research on Ecosystem Services in Farmlands
Agriculture is a significant driver of Ontario’s bio-economy and food security. It provides many important environmental
goods and services and, as a livelihood practiced mostly by individuals and families, it has important social and cultural
value. Over the past few decades there has been an alarming loss of biodiversity in farmlands. This is critically
important to Ontario because farmland biodiversity is linked to agricultural production and its resilience to climate
change. Biodiversity enhances farm production, particularly with changing environmental conditions, by maintaining
ecosystem services including pollination, pest control, water quality and flow regulation, and soil health. The existing
CFI/OIT-funded Geomatics and Landscape Ecology Research Lab (GLEL) is a unique facility in Ontario and Canada,
integrating geomatics and landscape ecology research towards understanding and informing wildlife conservation. The
proposed infrastructure will allow development of research capacity focused on the relationships between the pattern of
farmland (i.e., the area under agricultural production), farming practices, biodiversity, and ecosystem services.
Farmlands are Ontario's most important land cover for maintenance of biodiversity and ecosystem services, and this
role is becoming increasingly important with growing human population and climate change. Farmlands present specific
challenges for geomatics and landscape ecology research due to their dynamic nature and the high-resolution imagery
needed for spatial and temporal analysis and mapping of landscape change. Over the next few years GLEL research
will produce major advances in understanding the relationships between Ontario farmland pattern (e.g., crop diversity,
field sizes) and biodiversity, pollination, and pest control. The infrastructure will allow us to expand this to farmland
effects on aquatic biodiversity, water quality and flow regulation, soil health, and the associated impacts of climate
change. The goals are to develop a comprehensive understanding of how farmland patterns and practices affect these
core ecosystem services, and what the expected impacts from climate change are, and to integrate these into the
development of farmland guidelines that provide enhanced resilience and sustainability in Ontario’s agricultural bio-
economy. The proposed research infrastructure includes renovations to enhance the functionality of existing space, to
house new equipment for research in terrestrial and aquatic ecosystem services to agriculture, and to provide upgrades
to key pieces of core equipment. This GLEL expansion is integral for us to remain at the leading edge of geomatics and
landscape ecology integration, and will allow us to extend our research in new directions to address important
questions on the role of farmlands for biodiversity and ecosystem services in a rapidly changing world.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Carleton University
Ms. Sandra Crocker, Associate Vice-President (Research Planning and Operations)
Phone: (613) 520-3570
E-Mail: sandra_crocker@carleton.ca

Lead Researcher(s): Hymie Anisman, Zul Merali
Brain imaging of stress-induced pathology: focus on depression and PTSD
Mental illness, particularly depression and PTSD, represents one of the most significant and prevalent socioeconomic
burdens affecting the quality of life and hydraulics of sustainable knowledge-based economy of Canada, with an annual
cost estimated at $51B. Maladaptive responses to stress contribute significantly to mental illness, yet the signalling
mechanisms underlying stress-responsive pathologies remain poorly understood. The requested infrastructure is a
multimodal brain-imaging instrument that will allow the researchers to ‘visualize’ not only where in the brain certain
circuits may be malfunctioning (through MRI), but also what neurochemical processes are altered (through
simultaneous PET imaging). This unique technological breakthrough will provide a shared platform to spearhead
imaging-based discoveries previously not possible, and will foster many multidisciplinary collaborations. Neuroscientists
(preclinical researchers) will work not only with clinical researchers (psychiatrists and psychologists) to develop
research-informed solutions for patients (bench to bedside and bedside to bench approach), but also with engineers
and physicists at Carleton (home to the Ottawa Medical Physics Institute, comprised of academic, hospital, government
[NRC, Health Canada], and the private sector researchers) at the technological and functional leading-edge (e.g.
innovative imaging resolution software & methodologies). The PET-MR will be situated at the Royal Ottawa Hospital
(dedicated mental health hospital and the home to the Royal’s Depression Centre) to facilitate access by prospective
patients as well as to a cyclotron (for labelled PET ligands) located at the adjacent Heart Institute. In addition, this
instrument will provide much needed capacity in Eastern Ontario for researchers working not only on the brain-based
disorders but also disorders involving other organ systems (e.g. cardiovascular, cancer, etc.), especially as many
physical health conditions co-occur with depression. Indeed, we will collaborate with the uOttawa Heart Institute to
better understand why people suffering from mental illness are at a significantly elevated risk of cardiovascular mortality
and vice versa. This technology will promote early detection and intervention strategies to reduce the social and
economic costs of depression and comorbid conditions, and will concurrently promote the development of commercially
significant and valuable intellectual property around novel imaging technology. This will be the first such instrument
dedicated to neuroscience and mental health research in North America, and will put Ontario at the forefront in Canada
and internationally.

Finally, there is currently a paucity of highly qualified personnel (HQP) in the medical imaging and translational
research fields. A major focus of our endeavour will be the training of HQP to build national capacity. We currently
have the critical mass to conduct all of the research we envision, and the convergent expertise will make possible
research and technological innovations that might otherwise go untapped. Having this state-of-the-art technology will
serve as a lightening rod to attract top international scientists to come here, enabling clusters of research to be
conducted beyond that outlined in this proposal and help define illness biomarkers (through imaging, biochemical and
genetic analyses), to enable the development of individualized treatment strategies. The unique hybrid PET-MR system
represents a key tactic to bring applied discovery and research to the next level.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Carleton University
Ms. Sandra Crocker, Associate Vice-President (Research Planning and Operations)
Phone: (613) 520-3570
E-Mail: sandra_crocker@carleton.ca

Lead Researcher(s): Anatoli Ianoul
Carleton University NanoImagingCEntre (NICE) facility to enable the development of
novel plasmonic nanomaterials
The plasmonic properties of metal (gold, silver) nanoparticles have been of interest since the discovery of surface
enhanced Raman and fluorescence phenomena some 20-30 years ago. Enhancement of electric fields near the
surface of plasmonic nanoparticles, due to the excitation of collective oscillations of free electrons, has since been
explored in various areas of science and technology, making nanoplasmonic research one of the most dynamic in
natural sciences. However, controlled fabrication of plasmonic nanomaterials was impossible until recently (5-7 years
ago) when advanced synthetic methods were developed that allow the fabrication of plasmonic nanoparticles of defined
sizes/shapes/materials - critical parameters in plasmonic applications. As a result, a new wave of nanoplasmonic
research has emerged. At Carleton, we are currently investigating unique plasmonic nanomaterials based on the
assembly of silver/gold nanocubes onto high refractive index dielectric substrates. The main areas of application for
these novel materials are in sensing technologies, solar cells, imaging and spectroscopy. In addition, these materials
can be easily integrated with other materials. Devices are being developed with the aid of several CFI/ORF supported
projects: “Facility for nanostructures, surfaces, and sensor interfaces (FANSSI)”, “Multi-applications photonic device
laboratory”, “Micro/NanoPhotonics laboratory”; and the NSERC strategic grant “The MOSAIC project: multimodal
optical sensor applications, interfaces, and controls”; these projects all contribute to this activity. The first IP
disclosures and licences are now being negotiated.

In order to enable the development of such novel plasmonic nanomaterials new infrastructure is required. The
proposed “Carleton NICE Facility” will include a scanning probe microscope for imaging plasmonic nanomaterials and
devices at nanoscales. The microscope will be equipped with a range of imaging heads, and will be able to provide
nanoscale topography imaging of nanoparticles in large or small scale samples, both in liquid and in controlled
atmospheres, and at varying temperature. The microscope will enable the characterization of nanoparticle size/shape
and distribution - parameters determining the particles’ plasmonic properties. A Raman imaging system will enable sub-
microscale (hundreds of nanometers) 3D Raman and fluorescence imaging of these novel nanomaterials and devices
in transmission and reflection modes at different excitation wavelengths. It will also enable imaging of the electric field
enhancement generated by such nanomaterials. Finally, a dark field microscope will be acquired for imaging plasmonic
properties of a single plasmonic nanoparticle supported by a dielectric substrate, or embedded in a nano/micro
structure/device.

A critical mass of novel nanomaterial researchers already exists at Carleton. Significant advances in their research will
be realised through the provision of essential resources currently unavailable on campus. The proximal positioning of
the requested Carleton NICE facility and the Carleton University microfabrication facility (CUMFF), will provide optimal
and “unique in the world” conditions for the rapid advancement of nanoplasmonic research and make new avenues of
research feasible. This will lead to the development of the novel nanostructures, surfaces, photonic devices, and
multimodal optical sensors necessary for new generation of clean technologies, biomedical devices, and solar cells.

The infrastructure will benefit Ontario directly by contributing to our positioning as a world class location for laboratories
specializing in nanotechnologies. As already demonstrated, new technologies will be incorporated into hi tech
manufactured goods, generating new revenues for the Province from sales or licensing.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Carleton University
Ms. Sandra Crocker, Associate Vice-President (Research Planning and Operations)
Phone: (613) 520-3570
E-Mail: sandra_crocker@carleton.ca

Lead Researcher(s): D.R.F.Taylor
Distributed Data Management Infrastructure for Local and Traditional Knowledge
New ICT infrastructure consisting of software, servers, storage, and networking equipment is required in order to further
develop and operate a distributed research system for the collection, analysis, dissemination and preservation of local
and traditional knowledge and research data, specifically focused on the needs of indigenous communities in Ontario
and Canada's north. Collaborative data management with communities poses many unique challenges. Connectivity,
culture, traditional research methods, preservation and possession concerns, education, technical capacity, and the
need for unique representations of data for northern and remote contexts (including remote areas in Ontario) are all
challenges that researchers face while working on social sciences in indigenous communities. Through previous
projects, these needs were identified and an atlas-based distributed data management system was designed and an
initial test version built. A pilot project was run with several communities. Based on the success of this work, and on
strong interest from a number of Canadian based researchers, international partners, and northern and rural
communities who need to use this system for important research projects, we propose to make the system fully
operational and available for active applied research in a significantly expanded range of research areas. This entails
completing the implementation of a number of specific software functionalities and tools to support operational use, as
well as a robust server and data storage environment with sufficient dependability and high availability.

Ontario will benefit in several ways. New databases, storage techniques and networking solutions will be developed
and refined that will strengthen Ontario’s ICT agenda. The project also addresses the neglected area of digital media
content, as GCRC atlases will be populated with innovative rich media content including video and audio streams.
Students working on projects using the infrastructure will gain from a strong, rounded grounding in a broad range of ICT
related disciplines.

The infrastructure is designed to collect and preserve local and traditional knowledge and make that information
available directly to members of communities and community organizations, and the implications for societal benefits to
Ontario are wide. For example, a new Lake Huron Treaty Atlas is being developed in conjunction with Anishinaabe
communities which may act as a tool in an increasingly difficult and complex process of reconciliation. A
Cybercartographic Atlas of the Risk of Homelessness in Canada has been created with input from Canadian
Municipalities. Many other projects are in progress or planned. The potential applications for the health of Ontarians
are also considerable. The lab’s worldwide profile is growing, and it contributes significantly to Ontario’s profile in the
global scientific community in digital media and information and communication technologies.

The proposed infrastructure, and the research it enables, will enhance Ontario’s strengths in cybercartography and in
the management of geographical information, especially as it relates to indigenous and local knowledge. This is a major
contribution to Ontario’s increasing involvement with the digital economy. This project will consolidate the position of
the Geomatics and Cartographic Research centre at Carleton University.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Carleton University
Ms. Sandra Crocker, Associate Vice-President (Research Planning and Operations)
Phone: (613) 520-3570
E-Mail: sandra_crocker@carleton.ca

Lead Researcher(s): Stephen Fai
Laboratory for Architectural Rehabilitation and Conservation (LARC)
This proposal will enhance the technological infrastructure of the CFI/ORF funded Carleton Immersive Media Studio
(CIMS). Consistent with Ontario's leadership role in both environmental stewardship and heritage conservation, we
propose the development of Canada's first research facility dedicated to digital acquisition, computation, and fabrication
as they are related to architectural rehabilitation and conservation. The "Laboratory for Architectural Rehabilitation and
Conservation" (LARC) will employ state-of-the-art technologies to address pressing multi-scale environmental and
technical challenges related to the long term management of cultural landscapes, urban and suburban infrastructures,
significant buildings, and cultural artefacts, a high proportion of which are in Ontario.

CIMS is a Carleton University research centre, with labs funded from earlier investments from CFI/OIT/ORF, which is
dedicated to the advanced study of innovative, hybrid forms of representation and construction that can both reveal the
invisible measures of architecture and animate the visible world of building. As part of the Carleton University’s Azrieli
School of Architecture, we are committed to exploring and developing innovative symbiotic relationships between the
digital and the fabricated. Our mandate includes the advancement and development of the tools, processes and
techniques involved in the transformation of data into tangible and meaningful artefacts that impact the way we see,
think, and work in the world. Carleton is poised to be an international leader in the deployment of these technologies for
the architecture, engineering and construction industry, with worldwide visibility.

In keeping with our mandate, this proposal will:
1. improve our existing facilities and acquire new technologies for the expansion of our digital acquisition capacity. This
lab will be used to enhance our current research program that deals with the transformation of artefacts, structural
components, buildings, and urban landscapes into digital form. The expanded acquisition lab will employ a wide range
of laser-based scanning technology and high resolution digital photography/photogrammetry. Our intention is to create
Canada's premier research facility for digital acquisition.
2. improve our existing facilities and acquire leading-edge equipment for advanced research in the architectural
applications of current and near-future digital fabrication technologies. The development of this research laboratory is
the logical extension of our current research program at CIMS. When our facility was conceived in 2004, the idea of
"printing" a building component directly from a digital model was science fiction—today it is possible.

The benefit to Ontario will be realized on several fronts. Firstly, our ongoing research in building information modelling,
augmented by the technology for real-time fabrication, will place Carleton and Ontario at the forefront of both
architectural rehabilitation and conservation. Secondly, the research will provide valuable insights that will help to
conserve Ontario’s rapidly expanding portfolio of heritage building, and may help to reduce future costs associated with
the maintenance of these structures. Thirdly, a significant number of HQP will be trained using the infrastructure to
pursue research studies, and will become valuable contributors to the Ontario economy. These personnel will be of
particular value, since they will have skillsets much broader that the typical IT graduate, and much deeper than the
average architecture student.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Centre for Addiction and Mental Health
Ms. Jessica Bowslaugh, Manager, Pre-Award – Research Proposals
Phone: (416) 535-8501 x6151
E-Mail: Jessica_bowslaugh@camh.net

Lead Researcher(s): Bruce G. Pollock, Peter St George-Hyslop
Pathways to Progress in Brain Disease
Innovative research in Ontario and around the world has resulted in a paradigm shift in how researchers -- and soon,
clinicians -- understand mental illnesses. Tremendous technological innovations can now support a wide variety of
brain research methods. Detailed knowledge of disordered biology is revealing how multiple small changes contribute
to the range of symptoms observed in a diagnosed illness. Some disease mechanisms, such as genetic mutations, are
shared between previously disconnected psychiatric and even non-psychiatric disorders. Collaboration between
scientists in different fields and neuroscientists of many specialities has the power to reveal a wide variety of
mechanisms relevant to neurodevelopmental and neurodegenerative illnesses and finally position disorders of the mind
as illnesses of the brain.

One in five Ontarians suffer from debilitating mental illness in their lifetime and neurodegenerative diseases are a key
emerging public health problem associated with aging populations. Ontario has a critical mass of scientists, particularly
neuroscientists, researching these disorders at a number of institutions but a consortium approach is needed to keep
capacity on par with jurisdictions such as China. The infrastructure requested here will enable a core group of
researchers at the Centre for Addiction and Mental Health (CAMH), the University of Toronto, the Tanz Centre for
Research on Neurodegenerative Diseases (TCRND), and the University Health network to collaboratively investigate
the most strategic and promising pathways to progress in brain diseases.

The regional research consortium seeks to deliver four key outcomes for Ontarians:
● new diagnostic technologies,
● innovative treatments,
● improved care systems, and
● improved population health

Prior infrastructure investments were received by consortium members through requests made between 2002 and 2008
and proved extremely timely, leading to phenomenal success, commercialization of new technologies, global
recognition for Ontario in these fields, expansion of programs and recruitment of a number of scientists from around the
world. The decade after 2002 witnessed profound advances in understanding neuropsychiatric and neurodegenerative
disease mechanisms, including breakthroughs made at CAMH and TCRND with the support of the Ontario government.

In order to continue to capitalize on prior infrastructure investments, a modest re-investment is needed starting in 2013,
one which can expand capacity on par with increased operational revenue secured by the consortium to support the
creation of a large number of new jobs for highly qualified personnel. Investments in five functional clusters will
accommodate new hires with cutting-edge environments and bridge current gaps in infrastructure that reflect
technological possibilities essentially undreamed of five to ten years ago:
1. Neuroinformatics
2. Next generation molecular and cellular research technologies
3. Enhanced neuroimaging
4. Innovative behavioural testing interfaces
5. A major coordinated bio-bank initiative

Leveraging previously acquired infrastructure such as gene sequencers and imaging machines with enhanced
analytical tools and computing that can turn the massive amounts of data generated into useful results at an
accelerated pace is a logical investment to keep Ontario at the global forefront of innovation.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Health Sciences North
Dr. Francisco Diaz-Mitoma, VP Research
Phone: (705) 523-7100 ext. 3655
E-Mail: fdiazmitoma@hrsrh.on.ca

Lead Researcher(s): Francisco Diaz-Mitoma
Translational Vaccine Program
The Translational Vaccine Program will identify, evaluate and develop candidate vaccines for human application. Our
research focuses on the preclinical phase of vaccine development, evaluating candidates through each stage of
development, which will allow us to bridge the gap between research and industry with the preparation of products
ready for clinical trials.


The main objectives of our program are three-fold;

1. To identify novel candidates for vaccine development against infectious diseases.
To achieve this, we plan to establish a library of clinical samples of Helicobacter pylori (H. pylori) isolated from patients
in Northern Ontario. The evaluation of multiple clinical isolates will enable us to identify potential vaccine candidates
against this pathogen. The establishment of a library will require additional storage equipment and growth facilities
including -80 degree Celcius freezers, incubators, fermentors, and anaerobic chambers.

2. To evaluate the efficacy and safety of promising vaccines candidates in pre-clinical studies.
Using immunological methods, preclinical studies will involve both in vitro and in vivo models to evaluate vaccine
efficacy and safety, readying vaccines for human application. We are currently evaluating several promising candidates
against hepatitis C virus (HCV), influenza and Campylobacter jejuni (C. jejuni) infections using these methods, which
include confocal microscopy and flow cytometry. Our technologies will require testing in suitable animal models and
must comply with Health Canada GMP standards prior to use in humans, as such, we plan to build a dedicated animal
care facility and a clean room for these purposes.

3. To develop novel vaccine delivery systems to facilitate vaccine delivery and efficacy.
Our team is currently investigating novel mechanisms of vaccine delivery with the aim of improving efficacy of immune
stimulation and modes of vaccine administration. Consistency in vaccine formulation is critical for effective vaccine
delivery systems; as such we will require instrumentation to evaluate the purity and stability of our formulations such as
equipment that can determine the size and charge of formulations (e.g. nanosizer), and can freeze-dry formulations for
long-term storage (e.g. lyophilizer).


The funding of this proposal will have several beneficial outcomes for Ontario. There will be job creation and the
formation of a highly skilled work force in the vaccine industry, development of vaccine prototypes so that they can
progress into clinical trials, and cementing the position of Ontario as a leader in the biotechnology industry. The
development of a strong Translational Vaccine Program will not only benefit Ontarians, by focusing on local health
priorities, but will also have worldwide applications since these priorities are shared by other communities in Canada
and internationally. The state-of-the-art facilities will also be able to attract other research scientists to collaborate in
vaccine research and development. Furthermore, the economic benefits realized by developing this infrastructure
program will be a reduction in health care costs in Ontario, as well as private investment for vaccine research in the
province.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Lakehead University
Dr. Rui Wang, Vice-President (Research, Economic Development & Innovation)
Phone: (807) 343-8201
E-Mail: rui.wang@lakeheadu.ca

Lead Researcher(s): Aicheng Chen
Advanced Materials and Technologies Innovation Centre for the Sustainable
Development of Natural Resources
AMTIC will focus on the study and design of biomaterials, functional materials and nanostructured catalysts to enhance
the economic and ecological development of the enormous forestry, mining and water resources of Northern Ontario.
This region spans a land area that extends 740 km west, from the White River to the Manitoba border, and 850 km
north, from the U.S. border to the coastline of Hudson Bay, and is replete with an abundance of natural resources,
which include ~18 million hectares of productive boreal forest and significant mineral deposits that contain gold,
platinum, palladium, nickel, chromite, copper and zinc. In addition, there are approximately 100,000 freshwater lakes
that provide some of the world’s best fishing and recreational areas. The objectives of AMTIC are three-fold: (i)
enhancement of the new Ontario bio-economy with a focus on the generation of value-added products from Boreal
Forest biomass; (ii) development of green technologies for metal refining; and (iii) advancement of emerging innovative
approaches for wastewater remediation and water purification to protect the precious natural freshwater resources and
to improve the quality of drinking-water in rural communities.

This project builds on the impressive strength in multidisciplinary materials, environmental research and natural
resource management expertise at Lakehead University. The proposed infrastructure includes a transmission electron
microscope (TEM), an X-ray photoelectron spectrometer (XPS), time-resolved fluorescence spectroscopy, an advanced
gel permeation chromatography system, and facilities for the pre-treatment of forest biomass. It represents a unique
addition to the research capabilities at Lakehead University. The proposed AMTIC is essential for the design and
characterization of novel biomaterials, functional nanostructured materials and innovative value-added products. It will
also facilitate student training at the undergraduate and graduate levels. In particular, it will attract highly qualified
students to the two new multidisciplinary PhD programs at Lakehead University: PhD in Biotechnology and PhD in
Chemistry and Materials Science.

The traditional forestry-based economy that has served as the economic engine of growth for most communities in the
North is facing severe challenges, and experiencing rapid and far-reaching structural change. Northern Ontario, with its
wealth of natural renewable forest resources, has the potential to become a focal point for Ontario's rapidly emerging
bio-economy. The proposed AMTIC will serve as a dynamic and exceptional regional and national hub for the
sustainable development of forestry, mining and water resources for the benefit of both Northern Ontario communities
and Canada as a whole.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Laurentian University
Mr. Daniel Archambault, Research Activities Manager
Phone: (705) 675-1151 x3446
E-Mail: darchambault@laurentian.ca

Lead Researcher(s): Zhibin Ye
High-Resolution Transmission Electron Microscope Facility for Multidisciplinary
Research in Materials, Biomolecular, and Environmental Sciences
Ranked as the top Canadian university for research income growth for two years in a row, Laurentian University is
making solid strides towards Canada’s emerging research university. Over the past years, Laurentian has witnessed
the establishment and advancement of a large number of new leading-edge research programs (headed by the
principal users of the requested facility herein, see next section) in various multidisciplinary areas including materials,
polymers, nanomaterials/nanotechnology, mineral, biomolecular and environmental sciences. Since their
establishment, the numerous innovative research activities carried out in these programs have earned themselves
distinct national/international recognitions, and have tremendously enriched Laurentian’s research environment and
enhanced our institutional strengths in these areas. These research programs have now evolved to become the major
pillars supporting Laurentian’s Strategic Research Plan. Despite their stellar growth and significant developments
achieved, the further advancement and success of these research programs to achieve international excellence,
however, depend stringently on the establishment of state-of-the-art materials characterization infrastructure. Among
them, the establishment of a High-Resolution Transmission Electron Microscope (HRTEM) Facility is key and pressing.

This intended Leading Edge Fund (LEF) / Ontario Research Fund proposals aim at acquiring and establishing a state-
of-the-art HRTEM facility to enable and support researchers in our collective innovative programs to carry out world-
class research and technology development at Laurentian. As an essential research tool for basic research in materials
and biological sciences, this HRTEM facility will be extensively used in our research programs to characterize the
important morphology and microstructure details of materials and micro-organisms at an atomic-scale resolution.
Complementing our existing infrastructure acquired through past CFI and ORF support, the establishment of this facility
will tremendously enhance our institutional capacity and strengths in these research areas, and help build leading edge
research programs. Its availability will also help attract and retain top-calibre researchers and high-quality personnel
(HQP) in these areas at Laurentian, who are critically important for the further advancement of our programs in the
region of Northern Ontario.

The establishment of this facility will foster existing collaborative initiatives and create new ones, both internally at
Laurentian and externally with industry and other institutions. Though such a facility exists in all research distant
institutions in Southern Ontario (usually more than one in most of them), it currently does not exist in any of the
institutions in Northern Ontario. Not only serving Laurentian researchers, this facility will also be a regional facility
benefiting a broad-base of users from academia, hospitals, and industry in Northern Ontario.

By enabling and supporting the world-class research, training, and education in our multidisciplinary research
programs, the requested facility will have important impacts on the economic growth and the quality of life in Ontario, by
developing/generating new materials, technologies, pharmaceutical drugs and delivery systems, innovative cancer
treatment methods, and new health and environmental policies/regulations.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Laurentian University
Mr. Daniel Archambault, Research Activities Manager
Phone: (705) 675-1151 x3446
E-Mail: darchambault@laurentian.ca

Lead Researcher(s): Tammy R. Eger, Alison Godwin
Research Infrastructure in Ergonomics and Applied Biomechanics to support
Occupational Health and Safety Research in Resource Based Industries
Research/Technology Development
The requested infrastructure will be used to carry out basic and applied research aimed at understanding injury and
accident mechanisms associated with the operation of equipment in resource-based industries. Using advanced and
unique methods of analysis, the interplay between line-of-sight, working postures, and vibration exposure will be
investigated with the aim to develop, evaluate and implement solutions to prevent traumatic and musculoskeletal
injuries associated with equipment operation.

Major Equipment to be Purchased
Building on infrastructure obtained from a previous Ontario Research Fund and Canadian Foundation for Innovation
grant, equipment upgrades and new equipment items are requested including equipment required to measure vibration
(accelerometers, dataloggers and analysis software), human motion (10-camera system and portable motion sensors),
muscle activity (electromyography unit with amplifier and interface board) and point-of-regard (eyetracking unit). A
robotic simulator to replicate vibration is also requested. Minor renovations to the current laboratory will also be
undertaken in order to accommodate the new equipment (i.e. electrical and lighting upgrades). New data analysis
workstations, to enable highly qualified personnel to analyze and process data, will also be required.

Benefit to Ontario and Canada
According to Statistics Canada 630,000 Canadian workers experienced at least one activity-limiting occupational injury
in 2003, representing a 3.8 % injury rate across all workers. However, the injury percentage was significantly higher for
equipment operators (8.2%) and workers employed in occupations unique to forestry and mining (5.3%). Furthermore,
employment in transportation and working shift-work were also positively associated with occupational injury.

In 2010, the Ontario Workplace Safety and Insurance Board (WSIB) reported a total of 154,862 workplace
injuries/illnesses including 67 traumatic fatal injuries. Between 2005-2009, 45% of all traumatic fatalities were caused
by transportation vehicles, power industrial vehicles, or powered mobile industrial equipment. Further investigations
point to impaired line-of-sight (LOS) as a primary cause of mining equipment accidents underground and coroner’s
inquests continue to highlight the need to address LOS from mobile equipment.

In addition to being at risk for accidents caused by restricted LOS, seated operators of earth-moving machinery,
statistically experience much higher rates of neck and back injury. Many tasks within the mining environment of
Northern Ontario include postures that require prolonged static positions of the neck for vision and repetitious
movements of the arm that may lead to increased risk of musculoskeletal injury. The impact for improving health and
safety of these workers can be transferred to many of the other resource-based industries of Northern Ontario, as well
as extension to the mining centers of the world (Africa and Australia). Failure to address the accidents and injuries
discussed above not only have a moral cost to society but also the financial consequences are appreciable: lost work
time and income, medical expenses, compensation costs, possible long-term health problems or disability (post-
traumatic stress). The proposed project will benefit Ontario and Canada by targeting these areas of concern.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Laurentian University
Mr. Daniel Archambault, Research Activities Manager
Phone: (705) 675-1151 x3446
E-Mail: darchambault@laurentian.ca

Lead Researcher(s): John Gunn
Infrastructure to Assess and Mitigate the Impacts of Contaminants, Climate Change and
Industrial Development in Ontario’s Far North
This application builds on the success of an earlier $1.4 M investments by ORF/CFI in the newly opened (August 2011)
Vale Living with Lakes Centre. The new investments will be used to address the laboratory equipment needs in two
primary research programs.

First, it will be used to greatly expand our studies of Hg bioaccumulation in food fish species in Ontario’s Far North
lakes and rivers (conducted in cooperation with OMNR, OMOE and First Nation communities). This monitoring and
survey program is designed to assess the effectiveness of decades of Hg emission reduction programs in Ontario.
Through this program we will develop the information needed to be able to make recommendations about safe
consumption levels of fish for First Nation communities participating in subsistence fishing. Secondly, it will help
establish a new program in Environmental Microbiology (CRC Tier 2 position announced 11/2011) to address the
function and role of microbial communities in extreme environments ( e.g. tailing ponds effluent, melting permafrost
areas). This program will address both basic and applied science questions related to microbial systems within the
extensive peatlands of the Hudson Bay Lowlands (the world’s 2nd largest wetland), an area where massive industrial
developments (e.g. Ring of Fire mining region) are planned, and also an area where climate change effects are
expected to be most severe.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


McMaster University
Ms. Kathy Charters, Executive Director, Research Office for Administration, Development
& Support
Phone: (905) 525-9140 x23735
E-Mail: chartersk@mcmaster.ca

Lead Researcher(s): Joaquin Ortega, Gianluigi Botton
A High-Throughput Cryo-electron Microscopy Facility for Biomedical Research
This proposal builds on the success of the Canadian Centre for Electron Microscopy (CCEM) for materials research
which was established at McMaster University through the investment of CFI and the Province of Ontario. We will
expand the research scope and capacity of the CCEM though the establishment of the proposed high-throughput cryo-
electron microscopy facility for biomedical research. The requested infrastructure will enable a large number of
research programs in Ontario. At the core of this facility will be a cryo-electron microscope designed for atomic
resolution imaging of biological specimens and soft materials. Research groups from Ontario and across Canada will
travel to McMaster University or operate the instrument remotely to obtain ultrahigh resolution images that will provide
the raw data for transforming discoveries in the area of biomedical research and biomaterials.

The proposed facility is critical to enable research programs led by highly accomplished and internationally recognized
researchers who have an impressive track record in scientific achievement. These researchers will capitalize on the
requested infrastructure to make groundbreaking discoveries in their respective research programs, which seek to find
new treatments for antibiotic resistant infections, cancer, heart disease, osteoporosis, AIDS, and a vast range of other
acute and chronic diseases affecting Ontarians. The facility will provide outstanding tools for these researchers,
accelerating the discovery of new drugs and treatments for these diseases.

The impact of the requested infrastructure will be amplified through the collaborations that these cryo-electron
microscopy groups have with other non-structural biology researchers across Ontario, Canada and internationally. The
requested infrastructure will therefore also impact research areas in biomedical research outside the expertise of the
main users, including, for example, stem cell biology and studies on the human microbiome that are helping to
understand how normal flora contributes to health and disease. The requested infrastructure will also open the
possibility for the cryo-electron microscopists in Ontario to initiate new collaborative opportunities with other groups and
work in areas presently not explored by electron microscopy techniques because of the lack of appropriate instruments.
These areas include, for example, characterization of biomaterials and biointerfaces used in implantable devices,
biosensors for diagnosis or drug delivery.

The requested infrastructure will facilitate recruitment of additional world-class structural biologists to Ontario. Attracting
and retaining these leading scientists and training the next generation of structural biologists is key for Ontario to
remain at the forefront of scientific research and to maintain Ontario’s tradition for innovation. The proposed cryo-
electron microscopy facility will provide opportunities for Ontario trainees to acquire hands-on experience with the most
technically advanced equipment and will foster excellence in training and innovation. Ontario’s visibility and reputation
in committing to research excellence will be dramatically enhanced by establishment of this facility. Many electron
microscopists in Ontario and around the world will rely on the high-throughput cryo-electron microscope facility to
collect data and to move their research programs forward. This will transform McMaster University and in turn Ontario
into a ‘hub’ for structural biology research.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


McMaster University
Ms. Kathy Charters, Executive Director, Research Office for Administration, Development
& Support
Phone: (905) 525-9140 x23735
E-Mail: chartersk@mcmaster.ca

Lead Researcher(s): Bruce D. Gaulin, Maikel C. Rheinstadter
Small Angle Neutron Scattering for Advanced Characterization of Nanostructure in
Materials (SANS for Nanostructured Materials)
SANS for Nanostructured Materials will give Ontario materials scientists and manufacturers a unique and important tool
for the advanced characterization of materials on the nano-scale, from 0.2 nm to 20 nm length scales range. This
capability is essential for characterizing materials and establishing structure-property and structure-function
relationships that ultimately lead to the understanding of the physical, mechanical, and rheological properties of a broad
range of materials, from magnetic storage and superconducting materials to new polymeric materials, to biological
materials of relevance to, for example, Alzheimer’s disease.

SANS for Nanostructured Materials will utilize neutron beams produced at the McMaster Nuclear Reactor (MNR), the
only reactor on a university campus in Canada. The SANS consists of three major components: the neutron optics
required to select the proper neutron wavelength and tailored characteristics of the incident neutron beam; the sample-
environment stage, and the position-sensitive scattered neutron detection unit. Through its interaction with the sample,
the neutron beam deviates from its original direction at very small angles of the order of a few degrees. To be able
resolve the deflected beam, a position-sensitive neutron detector is placed at large distances of up to 10m behind the
sample. To avoid air scattering and absorption, the detector must be placed in an evacuated housing, a 10m long
detector tube with a diameter of about 1.5m.

In many materials the information obtained by SANS is unique and cannot be obtained by other techniques, such as
electron microscopy or atomic force microscopy. The neutron probe is non-invasive and deeply penetrating. Materials
can be exposed to a variety of relevant conditions, including strong magnetic fields, extremes in temperatures, high
pressures, external shear, controlled humidity, and conditions necessary to mimic physiology.

Only three university-based nuclear reactors exist in North America. Ontario and McMaster are in an exceptionally
strong position to exploit this source of neutrons. Canada’s largest centre for materials research, the Brockhouse
Institute for Materials Research (BIMR), is right next door to the MNR and will be a critical partner in this forefront
program of discovery and characterization of new materials using SANS for Nanostructured Materials. Furthermore,
SANS for Nanostructured Materials will be available to and used by materials researchers from neighbouring Ontario
universities, especially the Universities of Toronto, Waterloo, Guelph, UWO, and UOIT. SANS will be a hub to this
wheel of closely located universities to enable collaboration with faculty and students from these institutions. Ontario is
North America's 3rd largest regional concentration of high-tech and biotechnology firms, and McMaster is a prime
location to build this forefront and unique instrument.

Innovation and the development of new materials with new and improved properties are critical capabilities needed to
support Ontario’s emerging knowledge economy. Many of Ontario’s challenges related to energy, the environment,
communications and health, directly relate to inadequacies in the performance of present day materials which underlie
these sectors. New materials with improved physical characteristics will provide Ontario manufacturers and industries
with the means to better address these challenges.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


McMaster University
Ms. Kathy Charters, Executive Director, Research Office for Administration, Development
& Support
Phone: (905) 525-9140 x23735
E-Mail: chartersk@mcmaster.ca

Lead Researcher(s): Ali Emadi, Saeid Habibi
Virtual Electric and Hybrid Electric Vehicle Powertrain Integration and Axle-Mounted
Chassis Dynamometer Facility with Vehicle-to-Grid Capabilities
Due to the exceptional sophistication of advanced electrified vehicles including electric, hybrid-electric, and plug-in
hybrid electric vehicles (EVs, HEVs, and PHEVs), current vehicle powertrain integration and chassis dynamometer test
and validation systems and strategies are not sufficient. This has recently been highlighted by the now infamous Toyota
unintended acceleration problem. There is in fact a dire need to provide manufacturers with a comprehensive research,
development, and test platform for modern vehicles under a very wide range of conditions to ensure powertrains,
components, and control systems provide safe and efficient operation under any possible conditions the end user may
encounter. The construction of a complete vehicle powertrain integration and axle-mounted chassis dynamometer
facility with vehicle-to grid capabilities that can accurately simulate all road conditions and drive cycles as well as test
advanced control and systematically map the vehicle operation under such varied conditions will be both internationally
unique in the industry and an exceptionally valuable tool for state-of-the-art research, development, and training. Its
uniqueness in Ontario will also enable its sustainability by providing service to industry.

Currently, individual components are tested and the complete system is simulated. When the components are
integrated, the system and controls have to be optimized. In addition, the system must be tested to verify it runs
properly under all conditions. Much of the integration testing today is done using complete vehicles on test tracks. While
the test track has been an effective tool, it is very time consuming and expensive; furthermore, testing the system under
all possible conditions is not practical. Much work has been done to perform more of these integration tests in the lab.
While progress has been made, accurate simulation of the interface between the wheel and the road has been difficult
to achieve. With the latest advancements in dynamometers and powerful control and simulation hardware and
software, it is now possible to simulate a very accurate wheel/road interface and load distribution on each axle.

The proposed infrastructure will include: four axle dynamometers; a low inertia, high response input dynamometer; a
variable voltage supply; an smart grid enabled bi-directional vehicle-to-grid converter; the drive system for the
dynamometers and battery simulator; a tilt/turn platform; and an advanced control and simulation system.

The proposed facility will be of great benefit to Ontario, a jurisdiction with one of the highest levels of automotive output
in North America. Ontario’s historical strengths are currently facing unprecedented challenges and fierce global
competition that threaten thousands of Ontario jobs. However, we have an excellent opportunity to position Ontario as a
global leader with the increasing market penetration of electric and hybrid vehicles. In order to survive and thrive, the
Canadian automotive industry—mainly located in Ontario—must innovate and pursue sustainable, electrified powertrain
technologies that will help secure continued market share. The requested infrastructure will be critical to support these
aims.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


McMaster University
Ms. Kathy Charters, Executive Director, Research Office for Administration, Development
& Support
Phone: (905) 525-9140 x23735
E-Mail: chartersk@mcmaster.ca

Lead Researcher(s): Stephen C. Veldhuis
High Performance Coating Laboratory for Manufacturing Tooling
When touring a manufacturing facility people’s attention is typically drawn to the complex machinery used in production,
and rarely to the tools processing the parts. In fact tooling is often overlooked as an area for process improvement.
However, the impact that underperforming tooling has on productivity, final part quality and other cost drivers, such as
labour, far exceeds its nominal value.

Tooling selection is one of the critical elements in setting production parameters. Thus a relatively inexpensive tool can
determine the utilization of high value capital equipment and often limits the types of materials that are practical to
include in a final product. In addition, frequent tool changes and subsequent setup activities as well as process tuning,
lead to high levels of manual intervention. This is needed to maintain quality levels, process performance, and
throughput - precisely the areas of productivity that all manufacturing companies are struggling with. Solving these
problems in a systematic fashion will provide Ontario manufacturing companies with a key competitive advantage.

Based on previous McMaster research, a novel approach to selecting and developing coatings and then optimizing the
manufacturing process parameters to fully exploit their unique properties was developed. Unfortunately due to technical
limitations the coatings must currently be produced by foreign partners with the significant disadvantage of needing to
disclose details on our formulations to them. This also results in substantial delays associated with coordinating
research over large distances. Even with these challenges full scale production tests performed at an automotive parts
supplier in Ontario showed a tripling of tool life and a one third reduction in manufacturing tooling costs as well as
reduced levels of manual intervention. The objective of establishing the High Performance Coating Laboratory facility
at the McMaster Manufacturing Research Institute (MMRI) is to accelerate and enhance these tool development
activities.

To accomplish this objective an advanced physical vapor deposition (PVD) coating system, together with the
associated pre and post cleaning equipment as well as highly specialized characterization and validation equipment is
required. By adding these items to the existing manufacturing and characterization equipment currently at McMaster
the laboratory will be able to deliver very unique coatings together with optimized processing conditions to meet the
needs of the demanding manufacturing applications used in Ontario.

Once the proposed facility is fully integrated into the MMRI this facility will develop, characterize, validate and deliver
custom coating solutions to Ontario manufacturing companies faster than is currently done with a higher degree of
flexibility in terms of the coatings being developed. This will directly enhance their productivity and quality while
minimizing their tooling costs and the amount of low value added labour expended per part. It will also enhance the
range of materials the manufacturers can process while allowing them to reduce the environmental impact of their
manufacturing processes. Overall this will provide Ontario Industry with a much needed competitive advantage over
other manufacturing jurisdictions.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


McMaster University
Ms. Kathy Charters, Executive Director, Research Office for Administration, Development
& Support
Phone: (905) 525-9140 x23735
E-Mail: chartersk@mcmaster.ca

Lead Researcher(s): Adam Hitchcock, Peter Mascher, Peter Kruse, Harald Stover
Magnifying Canadian Leadership in X-ray Microscopy: Enhancing the
Spectromicroscopy Beamline and Endstations at the Canadian Light Source
The soft X-ray spectromicroscopy beamline (SM) at the Canadian Light Source (CLS) is a successful facility,
competitive with soft X-ray spectromicroscopy facilities at other synchrotrons. However there are aspects of current SM
that significantly limit its performance relative to planned research. The major components of the proposed upgrades
that are critical for planned research are:

Upgraded monochromator: Although SM works at the S 1s edge (2460 eV), the flux above 1800 eV is quite low and
there are significant limitations to its performance relative to its outstanding performance at lower photon energies. A
novel multilayer coated grating will give 2 orders of magnitude improvement above 1800 eV, which is essential for
many research programs from semiconductor strain metrology to biological and environmental applications. This new
optic will require a new vacuum housing, which will be built in Ontario.

Upgraded photoemission electron microscope (PEEM) branch focus optics: At present PEEM cannot achieve its
highest possible magnification because of mechanical vibrations and the low flux density, which is associated with
imperfections of an elliptical refocusing mirror. By replacing this device with a Kirkpatrick Baez focusing optic and
mounting it on the same table as the PEEM, mechanical instabilities will be minimized, the spot size significantly
reduced and the flux density improved.

Enhancements to PEEM: The energy filter (funded by a 2003 CFI/OIT grant) provides a very useful enhanced
capability. By implementing a switching system it will be possible to use both filtered and unfiltered operation without
major down time. This will allow the full capabilities of both the energy filtered PEEM and unfiltered operation to be
accessed.

Rebuild scanning transmission X-ray microscope (STXM): The present STXM uses mechanical stages that have
lubricants which contaminate samples and prevent cryo-operation due to poor vacuum. Replacing the present stages
with vacuum compatible, higher performance devices and replacing the vacuum tank will vastly reduce contamination
and enable true cryo operation.

These upgrades are critical for a number of research areas, many with benefit and strategic value to Ontario, including:
1. Optimization of automotive fuel cells is being carried out by Hitchcock in collaboration with the Automotive Fuel Cell
Cooperation (AFCC, a Ford, Daimler partnership), and with researchers from Queen’s and Waterloo, through a network
project funded by the NSERC-administered Automotive Partnership Canada (APC), a program designed to assist the
Canadian automobile industry during the great recession. As Ontario’s economy is quite dependent on the automotive
industry, helping Ford to optimize and ultimately implement automotive fuel cell technology will help Ontario meet its
societal, environmental and economic goals.
2. An NSERC strategic project to use the CLS-SM PEEM to image and quantify strain and chemistry at the nanoscale
will be able to achieve its goals with these improvements. This project is assisting optimization of a new light emitting
technology which is being developed in part by Peter Mascher’s group at McMaster University. If the development
proceeds as expected, a new industry for light emitting devices could be created in Ontario.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


McMaster University
Ms. Kathy Charters, Executive Director, Research Office for Administration, Development
& Support
Phone: (905) 525-9140 x23735
E-Mail: chartersk@mcmaster.ca

Lead Researcher(s): Brian E. McCarry
Centre for Biomolecule Analysis and Discovery
Project Vision: Our vision is to create an integrated research facility with instrumentation which chemists, biological
scientists and health scientists can use to identify chemical and biochemical markers that differentiate between healthy
and diseased states, and between control and treated populations of organisms.

Biochemical markers are invariably small molecules (i.e., molecules below 2000 atomic mass units) that are usually
cellular metabolites whose levels change in response to stresses or diseases. Sensitive instruments will quantify a wide
range of biomolecules; statistical analyses will help identify indicators of infections, disease states and stress
conditions. Bioassays and imaging methods will be used to detect and localize indicators in organisms, tissues and
humans.

Project Goals: Our goals are five-fold: (1) to identify and characterize unique biomarker(s) of diseases using state-of-
the-art analytical equipment; (2) to develop robust analytical methods for use in the research lab and the clinical lab; (3)
to validate these methods; (4) to develop biosensors and bioassay methods as reliable devices; and (5) to translate
these methods for routine use in the clinic and beyond.

This opportunity is extremely timely and exciting; the proposed centre will be the first in Canada to provide access to
the best analytical and structure determination facilities and will serve as the central node linking four biomedical
research institutes to two research enterprises at McMaster with direct links to commercialization through the materials
and biomedical corporate sectors. No research groups or research consortia in Canada have access to this range of
facilities at one site.

Infrastructure: We request state-of-the-art infrastructure for the analysis and detection of small molecules in biological
samples, including equipment for sample preparation, sample clean-up and analysis. Separation methods will include
liquid chromatography, gas chromatography and capillary electrophoresis as front-ends to different types of mass
spectrometers, ranging from robust time-of-flight and quadrupole systems to high-resolution mass spectrometers
capable of tandem MS experiments. The most innovative instrument will be a 12 Tesla Fourier transform mass
spectrometer capable of ultra-high resolution mass measurements with an imaging accessory for cells and tissues. The
equipment requested will not duplicate existing infrastructure and will fill a critical gap at McMaster.

Innovation: The innovation in this project lies in the ability (a) to perform both targeted and comprehensive chemical
analyses and molecular profiling of biological sample types and (b) to conduct in vivo imaging to localize large and
small molecules within cells and tissues. Research programs using this infrastructure will then be able to monitor
changes in healthy versus disease states, to examine the localization and roles of small molecules in cells and tissues,
and to translate methods into the clinic and beyond.

Benefits to Ontario: Biomarkers of disease will play an increasingly important role in health care management in the
future. Recently, certain ceramide lipids have been shown to be predictive biomarkers of heart disease in humans.
Reliable methods to determine indicators of disease will allow the identification of diseases at earlier stages and early
intervention. Benefits to Ontario include substantial health care cost savings, realized from early detection of diseases
and improved quality of life.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Mount Sinai Hospital
Dr. Gareth Taylor, Director, Government Research Infrastructure Program
Phone: (416) 586-3125
E-Mail: grtaylor@lunenfeld.ca

Lead Researcher(s): Stephen J. Lye
Developmental Trajectories to Improved Health, Learning and Social Functioning
Many of the most pressing problems our society is likely to face over the coming decades are ones that could be
prevented, or largely mitigated, by early intervention. Pregnancy and early childhood represent critical developmental
epochs that impact health, learning and well-being throughout our lives. Pregnancy complications such as preterm
birth, preeclampsia and fetal growth restriction result in significant perinatal death and disability. Furthermore, it is now
clear that suboptimal growth and development of the baby during pregnancy and adversity in early childhood contribute
major risk factors for the development of later-life disease (including obesity, diabetes, cardiovascular disease and
mental illness), learning disorders and anti-social behaviour, that threaten the sustainability of our health, social
services and educational systems.

Our goals are:
1) to identify informative biomarkers and define molecular mechanisms responsible for the major pregnancy
complications such as growth restriction, preeclampsia and preterm birth, 2) to determine how adversity during
pregnancy and early life impact the establishment of developmental trajectories to later life health, learning and social
functioning, and
3) through the promotion of interventions that seek to optimize individual developmental trajectories, enhance
developmental potential of our children and prevent or mitigate the impact of early adversity.

The proposed infrastructure will provide new capacity and capability to drive integration of investigations across the full
spectrum of transdisciplinary research towards improved outcomes and knowledge translation. Platform 1 will integrate
with existing infrastructure to enable an in depth, comprehensive, discriminatory phenotyping capability in areas of
maternal-fetal and neonatal health (including ultrasound and MRI imaging, cardiovascular and metabolic
instrumentation), as well as behavioural phenotyping of children / families and of translational capability aimed at
improved learning (through innovative behavioural and learning laboratories). Platform 2 will establish enhanced GLP
infrastructure for human biospecimen collection and archiving. Leveraging the high quality datasets generated from
platforms 1 and 2, Platform 3 will provide technologies (cell isolation, mass spectrometry, next generation sequencing
for epigenetics) to define the mechanistic pathways responsible for pregnancy complications and the establishment of
adverse developmental trajectories in early life, as well as the development of biomarkers that are predictive of these
conditions. Platform 4 (imaging, phenotyping and genetics) will enable the validation of these data, including those
related to gene-environment interactions generated from studies in animal models.

Training programs within this new multidisciplinary research model will equip HQP with valuable capabilities to move
seamlessly between previously isolated disciplinary silos thereby enhancing productivity and competitiveness. The
infrastructure will enable researchers to test novel interventions to enhance health, learning and well-being, create
opportunities to grow the economy through the commercialization of predictive, diagnostic and therapeutic tools across
health, learning and wellbeing and build programs and policies for children that are based on the best available
scientific knowledge. Through existing collaborations, new national / international research networks and partnerships
in low resource settings, we will contribute to global alliances focused on maternal – child health, well-being and
enhanced human potential.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Mount Sinai Hospital
Dr. Gareth Taylor, Director, Government Research Infrastructure Program
Phone: (416) 586-3125
E-Mail: grtaylor@lunenfeld.ca

Lead Researcher(s): Katherine Siminovitch, Rita Kandel, Jordan Lerner-Ellis
A Next Generation Framework for Personalized Healthcare
New knowledge and technologies related to molecular diagnostics are rapidly increasing opportunities for physicians to
individualize medical treatment so as to optimize health outcomes and improve quality of care. By connecting all
clinical, molecular and histopathologic patient data within an integrated electronic system, we will create a next
generation platform for medical decision-making, and enable the translational research required to expedite application
of genomic knowledge to medical benefit.

AIM I: To create and deliver a knowledge and operational framework for incorporation of genomic sequence data into
the practice of molecular diagnostics. We will use several single gene-inherited cancers, cardiac conditions, and other
adult onset genetic disorders with high morbidity and socioeconomic burden, as exemplars for creating a technical,
analytic and communications pipeline. We will build upon our access to massive collections of patient populations and
our collective expertise in next generation sequencing (NGS), bioinformatics, medical genetics, knowledge translation
and bioethics, to develop: optimized tools for discovery of disease gene variants; and efficient, ethical strategies for
communication of such information to physicians/patients. While it will take time to delineate clinical relevance of
genetic variants underpinning complex, polygenic diseases and incorporate such data into diagnostics, NGS has
immediate potential to transform molecular diagnostics of Mendelian (single-gene) disease.

AIM II: To develop/validate a novel, broadly applicable and intelligent digital pathology program, using selected cancers
(breast, colon, etc.) as proof-of-principal. Digital pathology and computer assisted image algorithms will be used to
devise intelligent quality assurance review based on tumour specific characteristics; i.e., “digital image signatures” for
specific cancers. We are a centre of excellence with clinical staff specialized in the diagnosis and/or treatment of these
cancers. Furthermore, we have >30 years of archived pathology and a clinical database with >4000 patients consented
for collection of clinical information. The research will integrate and leverage pathology specific data, genomic
signatures, and information available in clinical databases to uncover diagnostic discrepancies that would not otherwise
be detected.

AIM III: To build an informatics platform for integration of clinical, molecular, and imaging data. The seamless
integration of DNA sequence, clinical and histopathologic image data into a single IT framework will have profound
implication for health care, enabling informatics-guided discovery of disease-relevant molecular and cellular signatures
and application of such knowledge to predicting risk, prognosis and drug responsiveness so as to improve health
outcomes.

This project will combine clinical, genomic, and histopathologic data and will serve as a proof-of-principle for an
integrated personalized healthcare platform, which will ultimately include additional sources of clinically relevant data
such as radiologic and biochemical/biomarkers.

In order to effectively implement these technologies, a significant investment in infrastructure is required to support
sample processing, tracking, image analysis/data storage (robotics, microscopes, software, scanners, servers,
freezers, refrigerators, incubators); DNA sequencing (Illumina HiSeq), and genotyping (Sequenom Analyzer 4); and
bioinformatics and data analysis (software and hardware).

By bridging the gap between technological capability and medical benefit, this project will yield multiple socioeconomic
benefits as it accelerates introduction of the “personalized healthcare” paradigm into our province and nation.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Queen's University
Ms. Mary Purcell, Manager, eQUIP Task Force
Phone: (613) 533-2757
E-Mail: purcellm@queensu.ca

Lead Researcher(s): Art McDonald, Mark Boulay, Mark Chen,
Technical Upgrades to DEAP_3600 and SNO+ for significantly increased sensitivity
The DEAP-3600 and SNO+ experiments situated at the new SNOLAB laboratory 2 km underground in Vale’s Creighton
mine near Sudbury, Ontario are two of the most sensitive particle astrophysics experiments in the world. These
experiments were awarded CFI and Provincial co-funding in 2009, $10.5 M from CFI and $9 M from Ontario. Since then
it has become possible to increase their technical capability substantially by the addition of 4000 kg of very low
radioactivity argon (Ar) and 1700 kg of neodymium (Nd), respectively.

DEAP-3600, using liquid argon,will be over 100 times more sensitive than existing experiments for the detection of the
Dark Matter particles that make up about 25% of our Universe. These Dark Matter (DM) particles are thought to be left
over from the original Big Bang and their gravitational attraction keeps our Galaxy from spinning apart. A complicating
factor for the use of ordinary argon is the presence of radioactive 39Ar atoms produced in the atmosphere that could
provide competing background signals in the DEAP-3600 detector. However, argon with 100 times lower 39Ar (Low
Radioactivity Argon or LRA) has been located at an underground site in Colorado and would provide a significant
advantage for the experiment. A detailed engineering design has been developed to increase the present extraction
and purification capacity from 100 kg/yr to 5000 kg/yr and produce4,000 kg of LRA forthe DEAP-3600 experiment.

The original funding for the SNO+ experiment included funds for 850 kg of neodymium (Nd) compound to be added to
the light-producing scintillator at the center of the detector to study neutrino-less double beta decay. Since then,
improved simulations of the detector show that with the addition of an additional 1700 kg of Nd the sensitivity can be
improved by 70%, moving the experiment further to the forefront of the field. The observation of this rare radioactive
decay will provide new fundamental information about the basic laws of physics, the basic properties of neutrinos, and
can help to explain the processes that led to the creation of matter after the Big Bang.

The improvements to these experiments will guarantee that they are leaders in the fieldof particle physics and
astrophysics. The DEAP-3600 experiment seeks Dark Matter particles left from the Big Bang at the same time as the
largest accelerator in the world, the Large Hadron Collider in Geneva,seeks to produce them for the first time since the
Big Bang. These experiments place Ontario science on the world scene in a very big way, inspiring and training a new
generation of the best students and creating local economic benefits via the employment of staff at SNOLAB, the
construction of equipment at SNOLAB and the visits of international scientists who will participate in the experiment.

High performance computing infrastructure for the storage and manipulation of data is also requested to support both
the DEAP-3600 and SNO+ experiments, which will begin extensive data acquisition in 2013 with a large amount of data
being created.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Queen's University
Ms. Mary Purcell, Manager, eQUIP Task Force
Phone: (613) 533-2757
E-Mail: purcellm@queensu.ca

Lead Researcher(s): Randy Ellis
Image-Guided Surgery for Animal Care (IGS-AC) to Develop New Procedures for
Oncology, Trauma and Arthritis.
The infrastructure will facilitate research into how new image-guided surgical procedures can be developed for large
animals and translated to address human and veterinary clinical problems. This will be the world’s first known operating
room for animals with state-of-the-art ability to acquire high quality 3D imaging such as computed tomography (CAT)
scans, and digital X-ray images. These images can be used by human and veterinary surgeons to plan, in real time, the
optimal approach for complex surgical procedures. This will complement the existing image-guided surgical suite in
Kingston General Hospital, facilitating the direct translation of novel surgical procedures to human patients.

As an operating room it will be able to accept the largest animals currently under care in Kingston, and those projected
to be kept. The room will include 3D locating technology that provides GPS-like positioning with submillimeter accuracy.
Combining the plan and localization, the surgeons can navigate and achieve their plans quickly and efficiently.

After the surgery, the equipment can again be used to quantitatively assess the accuracy of the overall process.
Anticipated use is for cancer surgery, trauma such as seen after motor vehicle accidents, battle injuries or major falls,
and joint problems from arthritis. The facility is intended to address diseases that affect most Canadian families, with
applications to animal care and humanitarianism in battle zones or earthquake-prone regions.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Queen's University
Ms. Mary Purcell, Manager, eQUIP Task Force
Phone: (613) 533-2757
E-Mail: purcellm@queensu.ca

Lead Researcher(s): Amir Fam
Moving Load Facility for Assessment of Bridge Strength and Durability
Bridges are critical components of transportation networks. Failure of these structures can have a significant impact on
the economy and more importantly can result in the loss of human life as illustrated by the recent collapses of the de la
Concorde overpass in Laval, Quebec (2006) and the I-35W bridge in Minneapolis, US (2007). Both bridges collapsed
after years in service due to long-term loading and deterioration.

The proposed project targets the following areas, in the context of useful life span of bridges under usual weather and
moving load conditions: (i) assessing current construction and rehabilitation techniques for bridge components (e.g.
decks, columns, and expansion joints) and (ii) assessing emerging and novel materials and methods for rapid
construction and rehabilitation of bridges (e.g. fiber reinforced polymers (FRPs), stay-in-place-forms, and coating
materials for sealing concrete). The proposed infrastructure will allow for bridge components to be assessed far more
realistically and accurately than ever before, through the development of three facilities: (i) a moving load simulator for
testing bridge decks and girders, (ii) a high capacity testing frame for testing bridge columns, and (iii) environmental
chambers. The moving load simulator will be the only facility of its kind in Canada, and likely in the world. For the first
time, this will enable accurate simulation of the fatigue deterioration arising from vehicles passing over bridges, as well
as the dynamic effect of traffic on bridges. Indeed, studies have shown that current fatigue testing methods using
‘pulsating’ load cycles on a single spot are far less conservative and lead to exaggerated service lives of bridges, which
could not be achieved under realistic moving loads. The environmental chambers will allow large-scale bridge
components to be exposed to conditions that accurately simulate the Canadian climate, including extreme temperature
cycling and exposure to de-icing salts. Finally, the high capacity testing frame will allow for testing of columns to failure.

The requested infrastructure will allow the researchers to build on established expertise in the areas of: (i) applications
of novel materials and construction methods, and rehabilitation of existing structures (Fam), (ii) the impact of extreme
temperatures and environmental conditions on structural performance (Green), (iii) the effect of mechanical material
degradation and fatigue on structural capacity (MacDougall) and (iv) the use of structural health monitoring techniques
and remote sensing methods to assess infrastructure (Hoult).

Ontario, like the rest of Canada, is facing an infrastructure crisis with regard to deterioration of bridges. In a report
published after the collapse of the de la Concorde overpass in Laval, it was reported that at least 32% of Ontario's
15,000 bridges and 52% of Québec’s 12,000 bridges, need rehabilitation or replacement. As such, proper assessment
of novel rehabilitation techniques, design and construction practices for new bridges is essential to accurately establish
their service lives and effectively manage public investments in upgrading our bridge infrastructure. The timing of
decision making with regard to replacing or rehabilitating a bridge is critical for life safety. If too late, a catastrophe may
occur. On the other hand, a bridge replacement decision taken prematurely may cost the province, and indeed tax
payers, heavily.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Queen's University
Ms. Mary Purcell, Manager, eQUIP Task Force
Phone: (613) 533-2757
E-Mail: purcellm@queensu.ca

Lead Researcher(s): Praveen Jain, Alireza Bakhshai
A platform for discovery: engineering a fast, flexible, green power network for Ontario
Smart microgrids are expected to be the main building blocks of the power network of the future. They will enable local
integration and control of renewable energy resources and loads as a united entity capable of operating in both grid-
connected and autonomous modes. Microgrids will have numerous benefits, including integration of distributed
intelligence within the future smart power system.

New technologies that must be developed and verified in the frame of smart microgrid development are:
1) accommodation of various renewable energy sources with a wide range of power generation capacities;
2) provision of uninterruptable and reliable electric power to the loads within the boundaries of the smart microgrid;
3) realization of innovative energy-saving technologies e.g. using renewable energy sources located in the smart
microgrid to supply energy to electric vehicles; and
4) maintenance of frequency and voltage within the standard range under all operating conditions while also satisfying
standard power quality indices.

Due to the nature of the power system, the effectiveness of these methods cannot be verified unless tested
experimentally, and thus a small scale test platform is proposed in this research.
Major equipment can be divided into five categories:

1) renewable energy sources and emulators;
2) power network passive components;
3) loads and electric vehicles;
4) control and power electronic devices; and
5) smart sensing, measurement and laboratory facilities.

The microgrid test platform will provide researchers across Ontario with a comprehensive experimental setup that
accurately depicts the dynamics and behaviour of a smart power network. Advanced control and power electronics
solutions successfully applied to this test bed can be easily integrated into the existing power network, simplifying
process of migration from the existing power system to a smart grid.

The proposed research focuses on creating a fast, flexible and adaptive grid that can accommodate use of emerging
innovative energy-saving technologies and control systems, one of the three main focus areas for Ontario identified in
the Green Energy and Green Economy Act, 2009. This in turn can play a key role in achieving Ontario’s Long-Term
Energy Plan, which states that reliable energy transmission and modern energy distribution are crucial to support
Ontario’s evolving energy supply mix, including the closing of coal-fired plants by 2014 and the further expansion of
Ontario’s clean energy resources.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Queen's University
Ms. Mary Purcell, Manager, eQUIP Task Force
Phone: (613) 533-2757
E-Mail: purcellm@queensu.ca

Lead Researcher(s): Zongchao Jia
Therapeutic Targeting of Protease Systems Involved in Cell Invasion
Cancer and cardiovascular diseases are the leading causes of deaths in Ontario. A feature common to both of these
diseases is the change in a diseased cell’s ability to move or invade. Cell invasion is a normal process responsible for
developing and repairing tissues. It involves cells recognizing external stimuli and responding by interacting with,
migrating through, and modifying the structure of the extracellular environment in a regulated manner. These events
involve numerous intracellular and extracellular molecules called proteins that interact with their targets in a prescribed
way. However, in cancer and cardiovascular diseases, the proteins involved in the cell invasion do not move or interact
in this prescribed manner, which leads to cancer metastasis or atherosclerosis. Detailed characterization of these
proteins and their interactions at the molecular, cellular and tissue level is required to fully understand the mechanism
of cell invasion under normal conditions and in disease states. This understanding will provide critical information that
will influence the design of highly effective therapeutic agents for these disease states.

X-ray diffraction and NMR spectroscopy are the only two available methods that provide information about the three-
dimensional structure of a protein and its interactions at an atomic resolution. To carry out these types of structural
studies, very pure recombinant protein or protein fragments are required, and facilities to generate these proteins are
requested. Additional structural characterization of the proteins and their interactions will be sought through a variety of
complementary biophysical methodologies, and will require a multi-angle light scattering system, an isothermal titration
calorimeter, a MultiPep peptide array, and an Octet Platform. In addition, a state-of-the-art cell sorting unit and a super-
resolution fluorescence microscope is requested. All of the requested infrastructure will provide the structural biology,
biophysical and cell imaging capability to characterize the proteins involved in cell invasion, and study their structure,
their cellular location, and their interactions with other biomolecules.

Current technological advances in cell imaging are now closing the resolution gap between cell biology and structural
biology. The requested infrastructure will allow for the synthesis of detailed structural biology information to a cellular
milieu to discover the structure and function of proteins involved in cell invasion. The proposed research will not only
yield critical and detailed information about cell invasion and its role in cancer and cardiovascular disorders, but will
also initiate new opportunities for the development of targets for therapeutic intervention. This work will position
prominent Ontario researchers at the forefront of this field of research, and has significant potential to positively impact
the health of Ontarians.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Queen's University
Ms. Mary Purcell, Manager, eQUIP Task Force
Phone: (613) 533-2757
E-Mail: purcellm@queensu.ca

Lead Researcher(s): Ian Moore
Deterioration and long term performance of buried infrastructure
Buried pipes are essential components of water and wastewater infrastructure and for transporting oil, gas, and water
from their sources, and other buried infrastructure products like stormwater detention systems are also important. Past
CFI-Ontario investments have established the GeoEngineering Laboratory at Queen’s as the leading international
facility for testing shallow buried pipe and other infrastructure. This has brought important research projects to Queen’s,
and generated substantial knowledge of fundamental and practical value. Many cities, counties, Provinces, and other
infrastructure owners now require that buried infrastructure last 75 or 100 years to maximize returns on investments
currently underway, while maintaining appropriate public safety standards. In this context, studies are needed to
establish the nature of deterioration processes for concrete, steel and thermoplastic pipes, and the soil surrounding
them, and to evaluate the consequences of leaking pipes and colloids on water quality.

The objective of this infrastructure project is to:

1. develop accelerated deterioration facilities for reinforced concrete and corrugated steel pipes,
2. develop heated air supply to accelerate creep and other time effects in during buried pipe testing of polyethylene and
polypropylene products,
3. extend our existing facility to simulate very deep burial to assess the maximum burial limits of new and deteriorated
pipes (expanding on successes testing shallow buried structures),
4. develop facilities modeling soil erosion around leaking sewer and water pipes,
5. develop a pressurized pipe facility to examine long-term accumulation of colloids on pipe walls and their mobilization
due to system disturbances, and
6. acquire equipment to characterise the backfill soil and polymer structures being studied.

These new capabilities enhance the work by Drs Moore and Brachman to develop safe and economic design for sewer
and water pipes, stormwater detention systems, and highway culverts (work that has guided and will continue to guide
pipe design, assessment and repair practices in Canada, the US and elsewhere). This benefits public and private users
of these products, as well as the corporations that develop and manufacture them. The new facilities will substantially
strengthen recent collaborations between Drs Moore and Filion to establish how deteriorated and repaired water and
sewer pipes influence water quality inside or outside the pipes (seeking to minimize contamination of drinking water
from the soil or from colloids growing inside the pipe, and prevent contamination of groundwater by sewage or other
fluids being transported). The work will greatly enhance collaborations between Drs Moore and Hoult answering the
question ‘how much pipe deterioration is too much deterioration?’, establishing mechanisms and rates of pipe
deterioration, so pipes can be designed to have the desired lifespan.

Thirty five highly qualified personnel have benefited from projects using Queen’s Buried Infrastructure facilities since
2002. Over the next decade the upgraded facilities will bring many new projects to Ontario and lead to even more
training of the people needed by Ontario’s outstanding engineering consulting industry.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Queen's University
Ms. Mary Purcell, Manager, eQUIP Task Force
Phone: (613) 533-2757
E-Mail: purcellm@queensu.ca

Lead Researcher(s): Douglas Munoz
Enhancement and development of new assessment tools for evaluation of brain
function and dysfunction
In 2001, Queen’s University launched the Centre for Neuroscience Studies (CNS) with a stated goal of developing core
research facilities to promote transdisciplinary cutting-edge research. The CNS aims to increase understanding and
classification of sensory, motor, and cognitive dysfunctions of various neurological and psychiatric disorders. The
program has integrated clinician and basic scientists into a team immersed in the development of the tools,
technologies, and therapies that will be translated into development of new diagnostic and assessment tools to identify
specific neurological and psychiatric disorders.

This initiative was seeded with a modest CFI grant (Flanagan et al 2001, ~$1 million) to develop parallel human and
monkey behavioural assessment laboratories in eye-hand coordination. In 2006 a larger CFI was awarded (Munoz et
al. 2006, ~$17.5 million) to combine the technologies of behavioural neurophysiology, functional neuroimaging, and
clinical behavioural assessment.

The current proposal describes the next phase of this program, which has 6 components of focus:

1) We plan to enhance our technological core that is responsible for so many parts of the technology development
required to build new assessment tools. This core includes a design engineer, machinist, electronics fabrication, IT
support, and computer software development.

2) To further refine our work with non-human primates (NHPs), we will now focus specifically on the development of
unique and novel NHP models of human neurological and psychiatric disease conditions to allow for further
investigation of disease mechanisms and testing of potential therapies. To achieve this goal we require modest
upgrades to our NHP housing facilities to accommodate more animals.

3) We need enhancements to our data analysis core because of sheer size and importance of this activity in the
training of highly qualified personnel. The research team has now developed core expertise in neurocomputation and
there are many more trainees that need access to these valuable resources. There is former teaching space within
Botterell Hall adjacent to the existing data analysis area that has recently freed up that is ideal for this purpose.

4) We plan to further develop clinical assessment laboratories that are located within the area hospitals next to the
various patient groups. We started with small facilities in St Mary’s of the Lake Hospital (chronic care) and at the acute
outpatient hospital in Hotel Dieu Hospital. We now plan to enhance these labs and build an additional core lab in
Kingston General Hospital (acute care).

5) We plan to further elaborate on our ability to make laboratories portable to take the lab and experiment to the patient,
wherever they may be. The technical core will develop and maintain these portable labs as they move around the
country.

6)We require modest upgrades to our core imaging facility, which was first established in 2005.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Queen's University
Ms. Mary Purcell, Manager, eQUIP Task Force
Phone: (613) 533-2757
E-Mail: purcellm@queensu.ca

Lead Researcher(s): Stephen Vanner
Human Laboratory For The Study and Treatment of Gastrointestinal Disorders
Novel discoveries, such as our ‘synthetic’ stool for the treatment of C. difficile infection, have tremendous potential to
treat gastrointestinal (GI) disorders. Unfortunately, the full potential of such discoveries has yet to be realized because
facilities necessary to expeditiously evaluate these treatments in humans prior to proceeding to large-scale clinical trials
are lacking. Our vision is to create a cutting-edge facility to enable study of innovative treatments and diagnostic
techniques in humans, which will also be recognized internationally as the premier center for the performance of
Industry-sponsored human research in GI Disorders.

The GI Disease Research Unit is a cohesive, internationally renowned, multi-disciplinary group of basic and clinician
scientists, ideally positioned to establish and operate the proposed facility.

Our design is driven by:
1) key discoveries from our previous ORF/CFI investments, which are now ready for study in humans;
2) priorities of our established and emerging Industrial and Academic partners; and
3) the requirement for flexibility and accessibility to quickly exploit new discoveries.

Our proposed facility, which will be strategically embedded within our ambulatory and in-patient hospitals and
associated basic science facilities, will be comprised of two modules designed to efficiently enrol patients, house the
necessary equipment for their study at site of care, and allow these studies to occur without impeding everyday patient
care.

Module 1: Human Disease: Pathophysiology, Diagnosis and Treatment.

This module will have both ambulatory and inpatient components. The ambulatory site facility will consist of:
i) a research endoscopy suite that will enable study of endoscopic technology, provide access to intestinal samples and
allow targeted installation of microbiome treatments;
ii) a human pathophysiology unit, in which parallel studies to characterize alterations in human GI tract function will be
performed; and
iii) tissue processing/biobanking laboratory, where human specimens will be processed and stored for further
characterization in patients with digestive diseases, with a view of establishing biomarkers and evaluating treatment
effects.

At the inpatient site, a quality-controlled program to collect surgical specimens from the operating room will be
established and linked to a new human cellular physiology lab and existing basic science and transitional facility, where
fresh tissue can be studied using a variety of physiological recording techniques, or fixed tissue processed for drug
receptor analysis.

Module 2: Generation of microbial ecosystems for treatment of human disorders.

Module 2 will be created within our basic science facility and supported by our University of Guelph partners. It will
comprise a unique, scalable, continuous culture (‘chemostat’) facility. This unique, ‘first in the world’ facility will be able
to create tailored, complex microbial communities for use in gut microbiota replacement or augmentation therapy, an
emerging treatment option for a wide variety of GI disorders.

This unique facility and program will benefit Ontario by rapidly commercializing new treatments and diagnostic
modalities for patients. With our established Industrial partnerships, new products for patients, and thus new jobs in
Ontario, will be created. The basic science-clinical-private partnership environment created by this facility will also
provide a unique environment for training future Ontario innovators.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Queen's University
Ms. Mary Purcell, Manager, eQUIP Task Force
Phone: (613) 533-2757
E-Mail: purcellm@queensu.ca

Lead Researcher(s): Wolfgang Rau
Dark Matter Search with Cryogenic Detectors – Experimental Infrastructure for
SuperCDMS at SNOLAB
Numerous astronomical and cosmological observations show that most of the matter in the universe consists of an
unidentified type of elementary particle which does not absorb or emit light, giving rise to the term Dark Matter. The
Cryogenic Dark Matter Search (CDMS) experiment has dominated the efforts of finding evidence for direct interaction
of dark matter particles with ordinary matter during most of the past decade. The successor experiment SuperCDMS
presently operates cryogenic detectors with an improved sensor technology at an underground laboratory in Minnesota.
Eventually, however, the sensitivity of those measurements will be limited by the remaining cosmogenic radiation which
reaches the experimental site through ~700 m of rock overburden.

To further improve the experiment it will be necessary to move to a deeper site. The most suitable laboratory for such
experiments is the recently completed SNOLAB near Sudbury, Ontario. It is not only much better shielded against
cosmogenic radiation due to its depth of ~2000 m, but also operated as a dust-free laboratory, reducing potential
interference in the experiment from trace contamination with radioactive species found in essentially any dust particle.

The experimental infrastructure to house the next phase of SuperCDMS will be set up at SNOLAB. With the planned
100-150 kg of target material in SuperCDMS we expect to reach a so far unprecedented sensitivity for the detection of
dark matter particles, due to the advanced detector technology and extremely low rate of interaction from other
radiation.

The infrastructure to be installed includes a novel type of dilution refrigerator, the device generating the low
temperatures required to operate the detectors (~40 mK or 0.04 degrees above the lowest possible temperature, 0K or -
273°C). The novelty of this technology is the method of reaching first temperature steps down to 4 K (-269°C): a
mechanical cooler (Pulse Tube Refrigerator) rather than liquid helium. This reduces the operational costs as well as the
need for human interference and interruption of the measurement to refill the cryogenic liquids.

Further included is massive passive shielding against environmental radiation from radioactive trace contamination in
the rock surrounding the laboratory, and an active veto detector to identify external radiation which may penetrate the
passive shielding and generate signals in the experiment similar to those expected from the dark matter particles.

This project is only possible due to substantial earlier investment by the Province of Ontario through different programs,
as well as the Canada Foundation for Innovation and other funding organizations, which funded the construction,
outfitting and operation of SNOLAB. This laboratory has been constructed with the vision to build an international centre
for fundamental science and bring scientists and experiments from all over the world to Ontario.

The experimental infrastructure requested here will leverage a significantly larger investment by US funding agencies to
bring SuperCDMS, a ~$30M project, to SNOLAB. This experiment will contribute to the solution of one of the most
challenging scientific questions and will help cement Ontario’s position in the centre of the map of fundamental
research.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Ryerson University
Mr. Paul McArthur, Grants/Contracts Officer
Phone: (416) 979-5000 x4841
E-Mail: pmcarth@ryerson.ca

Lead Researcher(s): Chil-Hung Cheng
Fuel Cells for Electricity Generation, Storage, and Micro-Grid Reliability
The goals of this research are to:
(i) enhance electricity utilization in Ontario, which has been suffering Surplus Baseload Generation (SBG) of electricity
during overnights and weekends; and
(ii) reduce the province’s carbon footprint by developing the technology to generate electricity from biomasses.

To achieve the above objectives, we will develop rechargeable polymer electrolyte membrane fuel cells (PEMFCs) to
store and generate electricity under the following two initiatives:

INITIATIVE I
A prototype rechargeable PEMFC will be built to alleviate the SBG status in Ontario. Several hydrocarbons exhibiting
the attribute of a reversible dehydrogenation-hydrogenation cycle will be utilized as the hydrogen reservoir for the
PEMFC. This reversible cycle is the rechargeability feature of the PEMFC. The rechargeable PEMFC will be utilized to
store excess electricity during off-peak periods, and to supply electricity during surges of electricity demand. Several
design variables will be investigated through experiments, mathematical modeling, and computer simulation. The
variables will be optimized to maximize the fuel cell performance in its designated application.

INITIATIVE II
In this simultaneous initiative, we will assess the feasibility of generating biofuels from agricultural waste in Ontario.
Intended to generate auxiliary electricity used in the PEMFC, these biofuels will be produced from biomasses such as
agricultural residues and waste oils. A successful development of biofuel generation protocols will not only reduce our
dependence on fossil-fuel based energy but also strengthen our ability to exploit renewable energies.

The following major pieces of research infrastructure (RI) will be acquired to carry out the aforementioned research
activities:
1. Potentiostat: an electrochemical cell system to test the electrical performance of the PEMFC. The requested model is
Solartron Pstat 1MS/s potentiostat including software for all direct current (DC) techniques like galvanodynamic and 4-
slot chassis.
2. GC/MS: a gas chromatograph along with a mass spectrometer to characterize the liquid and gas phase composition
of the PEMFC. The requested model is Shimadzu GC-2010/QP-2010.
3. Fermentation Kit: a 14-L bio-reactor with cooling water jacket that will be utilized for bio-oil generation. The requested
model is New Brunswick Advanced Fermentation Kits.
4. Computation Device: 4 computers with Dual Six Core Intel® Xeon® Processor X5690, 3.46GHz,12M L3, 6.4GT/s,
24GB, DDR3 RDIMM Memory, 1333MHz, ECC (12 DIMMS). These high-performance computers will be used for
calculations in computational fluid dynamics (CFD), simulation, and optimization.
5. Thermomechanical fatigue (TMF) testing system and creep-/stress-rupture tester: equipments will be applied to
determine thermal and mechanical stress and strain characteristics, and the creep resistance of fuel cell components
under charging-discharging cycles.

Upon successful acquisition, the research team can enlighten our insights into the material science and power-grid
stability of rechargeable PEMFCs. In parallel, strategies of generating biofuels from waste biomass will evolve. The
research outcomes will benefit Ontario in three ways:
(i) establish enhanced stability and efficiency of electrical grid systems;
(ii) contribute advanced and leading technologies to the fuel cell industry; and
(iii) reduce carbon footprint by taking measures towards meeting environmental challenges.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Ryerson University
Mr. Paul McArthur, Grants/Contracts Officer
Phone: (416) 979-5000 x4841
E-Mail: pmcarth@ryerson.ca

Lead Researcher(s): Tony Hernandez
Cloud-based Analytics for the Commercial Sector
Prosperity in the new economy in both social and economic terms will be largely determined by the ability of
governments, organizations and communities to realize the potential offered by new technologies. These new
technologies centre on rapidly developing modes of mobile learning and communication. Within both the private and
public sector the forces of globalization, competition and concentration, along with the need for accountability,
transparency and risk management have led to an increased need to support and justify decisions with timely data,
analysis and insight.

Mobile technologies (such as smartphones, tablets, and netbooks/laptops), coupled with cloud computing that facilitate
“virtual” workspaces, are increasingly revolutionizing the way in which data is collected, shared, analyzed and utilized in
decision-making. Global positioning system (GPS)-enabled devices and associated location referencing within
Geographic Information Systems (GIS) now facilitate the creation of endless streams of data that are both spatial
(varying across space) and temporal (i.e., time-stamped static snapshots to real-time tracking). GIS functionality can
now be accessed in a multitude of ways to provide organizations with location-enhanced information. The GIS industry
is witnessing a seismic shift from traditional “back-office” desktop systems to mobile, internet-based cloud GIS (such as
Google Earth).

The proposed program of research at Ryerson University’s Centre for the Study of Commercial Activity (CSCA) aims to
enhance the adoption, use and impact of mobile learning and communication technology, through the development of a
mini-cloud geospatial platform within the consumer service sector. The research will also extend to impacts on
associative groups: in urban growth management, neighbourhood diversity, community health, small businesses, and
commercial real estate. The consumer service sector of the economy is highly competitive, contributing approximately
one-third of Canada’s GDP and accounting for more than 220,000 business establishments across Canada, and has
been one of the main contributors to growth in industrial productivity in Canada during the past two decades.

The research infrastructure, comprising high-speed network servers and switches, data storage and network security
along with software to develop cloud-based GIS analytics, will facilitate a research program that focuses on:
(i) improving the currency of location-based information through mobile-enabled data collection;
(ii) developing mini-cloud–based structures (that is, a “cloud” focused on the consumer service industry) to provide
stakeholders with more immediate access to this knowledge; and
(iii) enhancing analytical and decision-making capability with relevant mini-cloud–based tools. The research will
promote the use, adoption and development of enhanced “virtual” spatial decision-making support by organizations in
Ontario and across Canada, putting them at the leading edge of this capability in the world.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Ryerson University
Mr. Paul McArthur, Grants/Contracts Officer
Phone: (416) 979-5000 x4841
E-Mail: pmcarth@ryerson.ca

Lead Researcher(s): Jelena Mišić
AMTyCo – Advanced Machine-Type Communications Laboratory
Machine-type communications (MTC) is quickly becoming the main enabling technology for a number of emerging
applications such as electronic health, smart power/smart grids, safety and security, and city automation. We will
investigate and design architectures, protocols, and security solutions for mobile MTC communications using both LTE
(Long Term Evolution by 3rdGeneration Partnership Project), an advanced cellular communications technology, and
existing low-power communications technologies such as IEEE 802.15.4/ZigBee. Major telecom operators and
equipment manufacturers in Ontario, including Bell, Rogers, and Ericsson, as well as a number of smaller players in the
ITC industry, will benefit from MTC research.

Communications and security in the Smart Grid will leverage MTC technologies and solutions to enable different
players in the energy field to integrate their systems in order to monitor, control, and predict energy production and
usage in an accurate, efficient, and secure manner. This research is of particular importance to Ontario, which hosts a
number of major players in energy production, transmission, and distribution.

E-health solutions necessitate the use of small, lightweight devices on, in, and around the human body where they form
Wireless Body Area Networks (WBANs). We will investigate the impact of signal propagation through tissue or close to
the skin, energy harvesting from the environment, low-power communication protocols, and security solutions that
ensure confidentiality of sensitive personal health data. This research is particularly important in view of the increasing
number of elderly people in Ontario and throughout Canada who will require remote health monitoring and rapid
treatment in case of emergencies.

We will extend ongoing work on smart cars, smart road infrastructure, and smart vehicular networks, where we focus on
performance evaluation, security implications, and performance-based design of protocols, algorithms, and security
solutions. This research will enable Ontario’s auto industry to improve the safety of its products and remain competitive
in the market. Our research in the mobile cloud computing area will address the most important limitations of this novel
computing paradigm in order to enable cloud operators to develop novel applications on a number of distributed
cloudlets, or cloud servers, and then offer such applications to clients over a 3G/4G cellular network or wireless LAN.
We will also investigate security protocols and security solutions to protect user anonymity and privacy while not
impairing perceived performance, thus enabling such applications to achieve widespread acceptance.

To this end, we propose to purchase advanced computer and communication equipment, and set up a laboratory
dedicated to advanced research in machine-type communications that will support a number of emerging application
areas, all of which are of crucial importance to Ontario’s industry and government. Ryerson researchers will be able to
continue the high-quality research they are known for, strengthening their existing ties with Ontario industry and forging
new ones. Ryerson will be able to recruit the best and the brightest among recent graduates, and train them to
contribute to the industry in Ontario. Thus, the proposed infrastructure will allow Ryerson University to foster research
as well as commercial innovations that will provide long-term benefits for the industry and society of Ontario.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Ryerson University
Mr. Paul McArthur, Grants/Contracts Officer
Phone: (416) 979-5000 x4841
E-Mail: pmcarth@ryerson.ca

Lead Researcher(s): K.Venkatakrishnan
Ultrafast Laser Nanofabrication Facility (ULANO-Facility)
This project proposes to establish a nanofabrication facility where nanomaterials and nanostructures will be fabricated
and characterized for the advancement of bio-nanotechnology, water quality monitoring and solar cell fabrication. The
main components of this facility are:
1) Advanced Mega Hertz (MHz) repetition rate femtosecond (fs) laser workstation will provide 100w at a 50 MHz
repetition rate and 200fs pulse width and be the first of its kind in the world, enabling us to generate nanostructures less
than 5 nm.
2) NanoRaman spectroscopy: Created nanostructured materials must be characterized to better understand their
properties; the optical method is important for biological applications and photovoltaic energy conversion. The
proposed equipment, a tip-enhanced Raman/fluorescence Spectroscopy (TERS) using a special Nano-antenna, can
break the diffraction limit of the light and enhance resolution to 10nm, many times that of any optical tool available in
the GTA. Integrating AFM/RAMAN/Con-focal microscopy in a single tool will enable nano characterization of samples in
a single scan and allow us to render a full 3-D confocal image.

MHz pulse frequency fs laser processing provides a new range of laser parameters and its application in
nanofabrication is unexplored. Using the proposed facility, we will carry out fundamental studies and applied research
based on recent discoveries by Ryerson researchers; most significant is that various types of nano-structured materials
can be generated. This process is unique: it is a single-step synthesis; a wide range of materials can be used as
precursors, including semiconductors, metals, alloys, ceramics, glasses, polymers and natural materials; and the
generated nano-structured materials are novel in terms of structures and chemical compositions. With assist gases and
catalysts, the method was also used to synthesize attractive nano-structured materials, such as nanoplatelets,
nanorods and nanotips. Unlike conventional nanostructure material synthesis, this method does not demand
sophisticated equipment or long processing. In fact, all syntheses were demonstrated under industrial-applicable
conditions. Equally interesting is that novel nano-structured materials were generated, specifically nanoalloys of
immiscible metals and hybrid nano-structured materials, and nano-structured ceramics generated from natural
materials (e.g., rice husks, wheat straw, egg shells). The unique structure of the nanoparticle network demonstrated
enhanced optical properties and biocharacteristics. The proposed facility would maintain our lead in this research
frontier.

We will focus on exploiting the theories of 3D nanofabrication by ultra-short pulsed laser ablation under ambient
conditions to provide us with greater control of nanostructure morphology. Its cost efficiency and non-toxic nature make
it an attractive alternative to conventional vapour condensation-based nanomaterial synthesis.

The synthesized nanostructured materials will be used to advance nano-biotechnology, regenerative medicine and thin-
film solar cells. The nanonetwork is particularly favorable for cell growth and can be used for building tissue scaffold.
With its increased surface area, the nanonetwork can be used to enhance biochemical sensing, applicable to DNA
sensing, MRI sensing and clean water detection. We observed a significant drop in reflectance of the irradiated
surfaces in the visible range — attributed to the increase in surface area of the laser-irradiated surfaces which in turn
increases the absorption of incident light — making them applicable to photovoltaic and other light-energy conversion.

The nanotech, bio-based and solar energy industries, the fastest-growing sectors of the Ontario economy, would
benefit from the establishment of such a facility through technology transfers and talent training.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Ryerson University
Mr. Paul McArthur, Grants/Contracts Officer
Phone: (416) 979-5000 x4841
E-Mail: pmcarth@ryerson.ca

Lead Researcher(s): Victor X.D. Yang
Optical Coherence Tomography (JTOCT) facility: supporting preclinical and clinical
research
Optical coherence tomography (OCT) is an emerging imaging technology that features near-histological resolution with
non-invasive or minimally invasive imaging, potentially applicable to a wide range of disease detection and therapeutic
monitoring processes. Outside of ophthalmology and cardiology, suitable integration of FDA-approved commercial OCT
engines with relevant preclinical or clinical target applications is lacking. With a clear vision to streamline translation of
OCT technology in an efficient manner to preclinical research and clinical applications, the research team from both
Ryerson University and St. Michael’s Hospital (SMH) propose to establish a Joint Translational Optical Coherence
Tomography (JTOCT) facility, located at the newly constructed Li Ka Shing Knowledge Institute, with participating OCT
engineers, scientists, and clinicians. Instead of targeting application areas by clinical specialty or discipline, which has
been the traditional pattern of OCT technology translation, the JTOCT adopts a cross-disciplinary approach, addressing
multiple clinical problems based on similarity of required OCT technical platform. The inclusion of collaborators from St.
Michael’s Hospital will enhance the JTOCT with research subprograms to meet the desired cross-disciplinary objectives.

The facility will house three FDA-approved OCT engines suitable for on-/off-label clinical research involving human
subjects, and two open-concept OCT engines suitable for application-specific modifications typically required for
preclinical animal experiments. All of these OCT engines are to be purchased as full systems or modular subsystems.
The JTOCT will be staffed by trained OCT imaging technicians. The imaging data generated by the facility will be
viewable on hospital medical imaging systems, thus further paving the way for translating OCT technology into
preclinical animal research and future clinical practice.

Ontario is a leader in biomedical research in North America, with education and hospital institutions investing $1.7
billion yearly. The JTOCT will not only complement the existing establishments, but also progress the research in
advanced health technologies to new levels that complement Ontario’s research excellence, and provide direct health
benefits through improved methods of medical imaging and diagnosis. The JTOCT will meet this outcome through the
creation of knowledge, commercialization of devices via collaborations, and the training of highly qualified, globally
competitive academic leaders. The installation, testing, and characterization of the OCT systems at the JTOCT will
support research collaborations at St. Michael’s Hospital, and potential research and industrial employment
opportunities with Ontario companies that will impact the global market.

OCT is a powerful adaptation to existing clinical imaging technologies and enhances the discovery and diagnosis of
many prevalent health issues prevalent. By utilizing OCT in pre-clinical and clinical settings, the JTOCT will yield
significant benefits in advanced health technologies for Ontario residents, and provide better services, improved
outcomes, and lower costs to the healthcare sector. The JTOCT will reap benefits of global market opportunities for
advanced health technologies by extending Ontario’s research excellence in medicine, medical devices, and disease
prevention and control. The proposed research group has the capacity to meet these objectives. The Ontario and
federal governments support a cross-disciplinary approach within a range of research fields, and the new knowledge
generated by our basic and applied research will stimulate industry-academia investment with the common goal of
promoting Ontario and Canada as global leaders in biomedical optics.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Ryerson University
Mr. Paul McArthur, Grants/Contracts Officer
Phone: (416) 979-5000 x4841
E-Mail: pmcarth@ryerson.ca

Lead Researcher(s): Michael Kolios
Laboratory for ultrafast ultrasound and optical methods used to probe cell and tissue
structure and function
In this project, novel ultrasound, photoacoustic and optical coherence tomography (OCT) technologies and algorithms
will be developed, as well as molecular theragnostic probes that will be used with these technologies (i.e., to be used
both as contrast agents for imaging but also in a therapeutic capacity). While the biomedical applications of these
proposed non-invasive imaging technologies are broad, the particular focus will be on cancer imaging and therapy, as
well as imaging the treatment response to therapy. The hardware requested for the imaging portion of the project
includes a photoacoustic imaging technology based on a high-frequency linear array (the VEVO LAZR system), a
custom-made ultrafast OCT device (based on components from THORLABS Inc.) and a clinical custom-made
photoacoustic imaging system based on the Ultrasonix Sonix-Touch platform coupled with the appropriate laser
system. Key to the proposed imaging technologies is the rapid acquisition of the ultrasound and optical data that enable
the specialized cell death detection techniques the group has developed over the years, which are based on how the
signals change due to therapy, but are also a function of very short timescales to assess cellular activity. The
theragnostic probes will be based on microbubbles and nanoemulsions that are loaded with optically absorbing
nanoparticles, primarily based on gold nanorod technologies. To characterize the microbubbles and their oscillations
when exposed to ultrasound, an optical microscopy system linked with a high-speed camera is requested. This camera,
in conjunction with the appropriate computational infrastructure that will be used to solve the unique theoretical models
of microbubble oscillation that we have developed, will allow testing of the theoretical model predictions. The models
have already provided rich insights into how to optimize these microbubbles for clinical imaging (increasing contrast)
and therapy applications (increasing cell permeability and drug delivery). To characterize interactions of nanoemulsions
with cells and tissues, a CytoViva 150 microscopy unit is requested to better understand the uptake and distribution of
the nanoemulsions and nanoparticulates, as well as a high-end Perkin-Elmer Spectrophotometer to provide accurate
measurements of the optical properties of these preparations. The group assembled to develop these technologies are
world leaders in their fields and have commercialized several of their inventions on ultrasound, photoacoustic and OCT
technologies. The infrastructure requested to support this work will enable the group to retain its leadership position in
the development of these technologies for cancer therapy and imaging, and allow them to expand into new biomedical
applications. The facility will permit the development of novel photoacoustic technologies and next-generation
ultrasound and OCT technologies based on the very rapid acquisition of data that allow the detection of cancer
treatment effects. Moreover, it will enable the scientific work required to design next-generation ultrasound, optical and
photoacoustic molecular theragnostic probes based on microbubbles and nanoemulsions loaded with nanoparticles,
with an emphasis on the interactions of probes with cells and tissues. A better understanding of the interface between
nanotechnology and biology would accelerate development of clinical-based applications.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


South Lake Regional Health Centre
Dr. Sharifa Himidan,
Phone: (416) 558-9070
E-Mail: Sharifa17@rogers.com

Lead Researcher(s): Dafydd “Dave” Williams, Sharifa Himidan, Peter C W Kim, John
                    Lymer
Development of Novel Hybrid Technology for fetal and oncologic Therapies
Semi-Automated MRI Guided High Intensity Ultrasound for Targeted Fetal Therapy
Some fetal oncological and nononcological conditions are associated with high rate of fetal loss and maternal
morbidity. Among them are sacrococcygeal teratomas and twin-twin transfusion.

The most advanced fetal therapeutic technique today is Radio Frequency Ablation ( RFA) which in itself is invasive ,
lacks precision and carries high risk of fetal loss, premature labor, and maternal morbidity.

This proposal stems from the critical need to reduce significant complications to both the mother and the baby caused
by current invasive mechanical paradigm of surgical intervention despite these most recent successes. We propose to
develop a magnetic resonance (MR)-guided semi-autonomous dexterous robotic high intensity focused ultrasound
(HIFU) technology for fetal intervention (a broader term ‘intervention’ is used instead of ‘surgery’). With this proposal,
we plan to change the paradigm of how future fetal interventions will be performed while creating a new technology and
techniques and generating new translational knowledge about fetal development, physiology, anatomy and pathology.

These applications will fully mitigate against the two Achilles’ heel of current fetal intervention that is injury and trauma
to a healthy mother and premature birth of fetus;

The purpose of the system is to deliver treatment to targeted fetal tissue in the womb. The system will advance the
state of current technology by automating the treatment procedure to improve efficacy and reduce surrounding tissue
damage by combining high intensity focused ultrasound beams that heat and ablate targeted tissue non-invasively, and
Magnetic Resonance Imaging (MRI) which visualizes patient anatomy, determines the location of targeted tissue and
permits control of the treatment by continuously monitoring the ultrasound beam focal point by MR-thermography.
Focused ultrasound therapies also include hyperthermic treatments to activate, attract or enhance the delivery of drugs .

A unique collaboration formed from a cluster of Canadian innovators lead by members of this team is poised to push
forwards Ontario’s agenda of becoming a capital of technology and medical innovation. The collaboration includes
world renowned scientists and clinical faculties with track Records from The universities of Toronto, Waterloo, Guelph,
and western Ontario in addition to international collaborators from the United States, Korea and Switzerland.

This initiative will bring into play, for the first time, a large community health care center as a lead institute, and in a
strong show of support, industry partners as co investigators and capital contributors rather than the traditional in kind
participation, a step that is necessary to bridge current gaps between translational research and commercialization and
to bring technology products closer to the end users.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


St. Joseph's Health Care
Ms. Stephanie Bowman, Manager, Grant Facilitation and Development
Phone: (519) 646-6100 ext. 65575
E-Mail: stephanie.bowman@sjhc.london.on.ca

Lead Researcher(s): Ting-Yim Lee, Glenn Bauman, James White
A large Area Detector Dual Energy CT Scanner for Low Radiation Dose Functional
Imaging Research in Oncology and Cardiology
Cardiovascular disease and cancer affect two out of every three Ontarians and cost the Ontario health sector 15 billion
dollars annually. With the proposed research infrastructure project, we will develop new CT imaging methods to more
accurately diagnose both diseases, which will lead to better therapeutic treatments and reduced cost for Ontarians.
Currently CT suffers from radiation risks by the use of x-rays and low sensitivity because it can only image anatomical
features of diseases but not the underlying mechanisms of diseases. Our research will add the missing functional
information to this high throughput and low cost imaging modality while greatly reducing x-ray dose. We are requesting
a large area detector dual energy CT scanner, which will be the first in Canada, to develop low x-ray dose dynamic
scanning methods with x-ray dye injection (functional CT) to derive objective measures of tissue perfusion (rate of
blood flowing into a tissue volume), blood volume and leakage rate of dye from blood to the interstitial space within
individual regions in tumors and the whole heart. In cancer, a greater leakage rate of x-ray dye may indicate a more
invasive tumor. In heart attacks, the leakage rate may indicate the extent of the damage to micro-sized blood vessels
that are nourishing the heart to maintain its function. As such, these blood flow measuring methods will have broad
clinical applications in cancer for predicting and monitoring response to anti-angiogenesis therapy and in ischemic heart
disease for identifying patients who would benefit from re-opening of occluded coronary arteries rather than medical
treatment. There are technological developments required to achieve the above applications. First, inaccuracies (beam
hardening artifacts) in CT images of the heart from presence of dye at high concentrations in the heart chambers need
to be corrected as they will affect the accuracy of perfusion calculated from the images. To address this we will combine
two approaches – CT scanning using two different x-ray energies and iterative image correction to minimize these
artifacts. Second, we will develop both hardware and software techniques to minimize the x-ray dose delivered by the
developed CT scanning studies to allow monitoring of disease progress/regression and treatment response at multiple
time points without concern that the x-ray risk will be excessive.

 In Ontario, the economic burden of cancer and cardiovascular disease is rapidly increasing as the population ages.
The proposed research infrastructure will help reduce these costs through development of low cost, low x-ray dose CT
imaging technologies that will allow for appropriate treatments that are tailored for a patient’s condition, thus avoiding
expensive unnecessary procedures. Additionally, this research will result in new job opportunities within the developing
field of functional imaging in Ontario and Canada. By retention of highly qualified functional imaging personnel, our
research may also foster collaboration with pharmaceutical and medical device companies at preclinical or clinical
testing stages of new drugs and devices. These new collaborations/contracts would further strengthen Ontario’s
pharmaceutical and medical device R & D and industrial sectors.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


St. Michael's Hospital
Mr. Dalton Charters, Director, Research Operations
Phone: (416) 864-6060 ext 2558
E-Mail: chartersd@smh.ca

Lead Researcher(s): Michael Cusimano, Howard Ginsberg, RJ Dwayne Miller, Francis
                    Talbot, Arash Zarrine-Afsar
Centre for Advanced Laser Applications in Surgery
Collateral damage to tissues surrounding the surgery site is a complicating factor that often reduces the patients’
recovery times, placing a burden on the healthcare system. In this regard, a technology that minimizes this damage and
offers accelerated healing is extremely beneficial to reducing the costs associated with patient care. Recurrence of
diseased tissue, such as tumors, because of incomplete removal also places tremendous strain on the health care
system as it necessitates further corrective procedures to ensure complete removal.

Picosecond InfraRed Laser (PIRL) scalpel developed by the applicants is a novel laser scalpel capable of cutting
through biological material without significant thermal or mechanical damage to surrounding sites. PIRL scalpel has
been shown to offer accelerated healing at the cut site with minimal scar tissue formation, compared to other methods.
In addition, cutting with PIRL releases molecular constituents of the diseased tissues allowing real time identification of
tissue types during laser surgery by capturing and further analyzing these molecules. Molecular fingerprint information
is far superior to other methods of identifying diseased tissues, and dramatically improves the chance of complete
removal of these tissues. In the quest to reduce the overall cost of the healthcare system, the proposed center aims at
developing specific surgical applications for this novel technology, and is expected to generate significant amount of
intellectual property with successful evaluation of each application. Given the current realization of Canada’s lagging
record in knowledge translation, the Centre will serve as a hub contributing to boosting innovation in Ontario. The
commercial objectives of the center are two-fold. (I) Development of an intraoperative PIRL scalpel for surgical
applications, and (II) demonstrate the utility of molecular information in guiding surgical diagnosis, treatment and
recovery. With each successful demonstration of an application, both of these objectives will generate tremendous
amount of intellectual property with possibility of licensing to generate further revenue.

In this proposal we have requested funding to assemble the necessary infrastructure including the laser system and
units required for molecular identification. This infrastructure will include two PIRL laser systems as well as
spectrometers for performing the molecular analysis. The first PIRL system will be dedicated to surgical testings and
will be interfaced with a robotic arm for improved accuracy. The second PIRL system will be combined to the various
mass spectrometers for molecular identification. The proposed centre will allow direct access to this novel technology to
surgeons in Ontario, attracting national early adaptors to evaluate and subsequently promote the PIRL system. This
interaction will be essential for the rapid adoption of this new technology in the rest of Canada and abroad.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


St. Michael's Hospital
Mr. Dalton Charters, Director, Research Operations
Phone: (416) 864-6060 ext 2558
E-Mail: chartersd@smh.ca

Lead Researcher(s): Xiao-Yan Wen
Toronto Zebrafish Gene Trap Facility
The use of model organisms has been vital to gaining an understanding of the function of dynamic genomes. Zebrafish
provide a unique vertebrate model system for functional genomic and developmental studies due to its embryonic
transparency, rapid and external embryonic development and fecundity. Furthermore, due to their physiological
similarity to humans and relative ease of genetic manipulation, they provide an rapid, inexpensive yet, powerful system
for disease modelling and high throughput drug screens.

Earlier this year, we organized a Zebrafish Functional Genomics Workshop at St. Michael’s Hospital (SMH). At this
workshop, we launched the International Zebrafish Protein Trap Consortium (IZPTC, chaired by Dr. Stephen Ekker)
involving four countries: USA, Canada, India and Singapore (http://www.ontariogenomics.ca/event/2010-12-07/607).
The goal of this consortium is, within the next five years, to generate 5,000 mutant zebrafish gene-trap lines with
characterized, RFP-tagged loci. NIH has already committed to funding the generation of 1,000 lines at Mayo Clinic,
USA. We proposed to generate 1000 fish lines in Canada to fulfill our contribution to the consortium. A CFI/ORF grant
is critical for us to build the infrastructure for the gene trap facility in Toronto that will foster and strengthen local,
national and international collaboration and partnership, leading to world-class scientific discoveries.

Our strategy is based on leading-edge technologies for zebrafish mutagenesis and transgenesis. Mutagenic transgene
will tag the gene with fluorescent markers (GFP and RFP). The fluorescently labeled fish strains will be amenable not
only to studies addressing gene function and disease mechanism, but also to high throughput drug screens. As this
screen is genome-wide and random, zebrafish mutants, corresponding to numerous and varied developmental
processes and disease models, will be generated and as a result, this project has already attracted over 20
investigators across Canada in many different research disciplines.

For this project, we propose to build an advanced zebrafish housing facility in Toronto with centralized filtration system
that would give us the necessary tank space for housing the thousand mutant gene-trap fish lines. Multiple embryo
microinjection stations and equipment for zebrafish phenotypic characterization are planned. A data management,
strain cryopreservation and distribution unit will be included in this facility. Funding for building renovation will also be
requested (~1,000 sq ft) with the estimated total budget approaching $2.25 million.

Synergising with the current Advanced Drug Discovery Facility and owing to the scientific merit of the proposed
research, this infrastructure will create resources that are academically invaluable and a centre that will train highly
qualified personnel (HQP) and nucleate visiting scientists and trainees from Canada and around the world. A
commercialization committee will be set up to direct the technology translation processes. Due to the integration of
innovative science, strong international partnership and broad participation from diverse scientific communities, this
initiative promises to transform SMH and Toronto into a hub for leading zebrafish research and discoveries in
translational medicine, ultimately promising advances in human healthcare.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Sunnybrook Health Sciences Centre
Mr. Kevin Hamilton, Director, Strategic Research Programs
Phone: (416) 480 6125
E-Mail: khamilton@sri.utoronto.ca

Lead Researcher(s): David Andrews
Identification and Validation of Novel Drug Targets in Cells, Animals and Humans
The infrastructure will be used to identify new drug targets for the treatment of human diseases. To identify these
targets we will use a technique called RNA inhibition (RNAi) to selectively shut off the expression of selected genes or
gene families in tissue culture models. Genes that when shut off provide a beneficial outcome, such as the selective
killing of cancer cells or survival of cells after a stroke, will be further investigated as potential drug targets. For each
disease model we propose to use published data and bioinformatics to select candidate genes to be investigated.
However, to identify genes not previously linked with the specific disease being studied and to permit us to investigate
multiple different diseases we must be able to comprehensively and systematically examine all of the potentially
druggable genes in the human genome. Furthermore, because of errors inherent in the RNAi process each gene will be
interrogated with 5 different inhibitory molecules.

To make it possible to assemble sets of RNAi molecules relevant for the disease model being examined and perform
the large numbers of assays required (up to 50,000 assays for each disease model) we will purchase a large collection
of DNA molecules that can be used to produce the RNAi reagents. For this approach to be practical requires advanced
robotics for storing and retrieval as well as copying specific subsets of these DNA molecules. The RNAi reagent (a
short hairpin RNA called a shRNA) will be delivered into cells using a virus. Thus, to inhibit each gene we will need to
assemble a virus carrying the shRNA. The assembly and storage of these viruses will be automated using robotics and
automated ultra-low temperature (-80 degree) storage systems. To determine the role(s) of specific genes in different
diseases we will examine the effect of inhibiting individual genes using automated imaging, image analysis and
machine learning technologies.

Genes that are identified as potential drug targets will be further validated using animal models and studies in human
patients. To study the effect of inhibiting specific genes in animal models of disease a virus carrying the appropriate
shRNA will be introduced into human cells grown in immune compromised mice. In other studies shRNA specific for
the corresponding gene in a mouse will be released from the blood stream of animals using recently developed
ultrasound techniques. Using ultrasound it is possible to deliver shRNAs to specific tissues including across the blood
brain barrier. This latter approach provides new avenues to use RNAi to study neurodegenerative diseases associated
with an aging population, stroke and brain cancers. Those shRNAs with therapeutic potential in the treatment of brain
cancers will be further assessed in human patients. The effect of inhibiting specific genes will be examined using MRI,
functional MRI, ultrasound and positron emission tomography.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The Hospital for Sick Children
Dr. Ramune Pleinys, Director, Research Opperations
Phone: (416) 813-5997
E-Mail: ramune.pleinys@sickkids.ca

Lead Researcher(s): Mark Henkelman
Imaging the Mouse
The completion of the human genome sequence, the sequencing of a number of other mammalian species (particularly
the mouse as a model system for human diseases) and the imminent availability of individualized human sequencing at
a reasonable cost (< $1,000 per individual), all converge to generate a tremendous opportunity and challenge to
understand the genetic basis of human diseases and to trace the molecular pathways and mechanisms involved in
these diseases.

Ontario has already made major research investments into genetics research and into mouse models of human
disease and is now recognized as a major contributor to the coordinated international effort on understanding how
genetic variability leads to human disease, and how specifically engineered mice manifest the changes of their
individual genes.

In its Life Sciences Strategy, Ontario acknowledges that it holds international leadership in making discoveries in
several areas, one of them being imaging, and is particularly well known for its unique contribution to imaging of mice
(see Ontario’s Visibility in the Scientific Community). Investments to date include funding through Ontario Innovation
Trust (OIT) contributions to several CFI grants, Ontario Research Development Challenge Fund (ORDCF), Genome
Canada programs, a couple of Ontario Research Fund and Ontario Brain Institute (OBI) grants.

This infrastructure application brings the nine-year old mouse imaging facility at the Toronto Centre for Phenogenomics
(TCP) up to date and extends its range of capability particularly into neuroscience and embryonic development, through
the acquisition of a high field and high throughput Magnetic Resonance Imaging (MRI) for longitudinal mapping of brain
changes along with behavioural testing to evaluate these changes; X-ray Computer Tomography (CT) and optical
imaging (OPT) for high throughput and automated three-dimensional imaging of mouse embryos, and a new kind of
computer-controlled 3D microscope to visualize the microscopic cellular basis of discovered changes.

The additional infrastructure investments will keep Ontario leading the world in mouse imaging; provide HQP’s with
unique skills that bridge imaging, genetics, mental health and development; preserve Ontario’s reputation within the
international enterprise that is understanding the relation of genes and diseases; and will ultimately transform health
care for all Ontarians.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The Hospital for Sick Children
Dr. Ramune Pleinys, Director, Research Opperations
Phone: (416) 813-5997
E-Mail: ramune.pleinys@sickkids.ca

Lead Researcher(s): Martin Post
Research Centre of Childhood Obesity and Brain Injury
We must study diseases such as obesity and brain injury in children in order to develop earlier intervention and
prevention strategies that will translate into reductions in health care costs across the lifespan. To perform these
investigations we need to strengthen our existing ORF-funded imaging, analytical and exercise research facilities.

Childhood obesity is one of the most alarming trends in public health due to its increased prevalence, the tendency for
obese children to remain obese as adults, and the increased risk of cardiovascular disease. The requested
infrastructure will allow us to apply the newest imaging technology and cardiovascular modeling techniques to
investigate the impact of childhood obesity on vessel structure and cardiac mechanics. It includes new 3-D
representation and printing techniques, fusion imaging (integration of ultrasound and MRI) technology, new MRI
sequences for our current 3T MRI and advanced ultrasound technology. This integrated imaging approach allows us to
develop targeted treatment strategies for identified children at risk for early development of cardiovascular disease.
Currently, we are investigating the pathophysiology of exercise intolerance in obese children. The next step is to
evaluate physical activity interventions to improve physiological function, disease status and quality of life in the
populations. To perform research studies on physical activity in field settings, or research studies on training greater
capacity (accelerometers, ergometers, treadmills) is needed. For exploratory lipidomics and metabolite analysis we
require new investment in analytical mass spectrometry. Furthermore, the exponential increase in requests for
singleplex- and multiplex-based analyte measurements requires investments in automation of both platforms.

Traumatic brain injury (TBI) is a leading cause of long term disability, and is especially devastating when it involves
infants and young children. The neuroimaging infrastructure that we are requesting will be dedicated to understanding
the effects of TBI and early brain damage on the developing brain, and monitoring interventions. This builds on our
previous and ongoing work with neuroplasticity -processes that allow brain recovery from injury- and is particularly
critical in the undeveloped brain. Infants and toddlers with brain injury, either acquired or due to accidents or birth
trauma, are in a very fragile medical condition. Thus, to study the brain structure and function of these infants, we need
an MRI very close to the intensive care wards, where they can be scanned with the least disturbance of ongoing critical
medical care. This infrastructure will also facilitate monitoring and follow-up brain imaging studies. The equipment
includes an MRI bassinet, which will help hold toddlers still during the scanning without sedation, with a child-sized MRI
coil which greatly increases sensitivity in the brain scans. The EEG systems will allow more continuous monitoring of
brain function during the critical stages following injury. We will be able to examine injury and recovery in infants and
children at a level that we have not been able to do before.

A focus on Childhood Obesity and Brain Injury will allow us to better understand the pathophysiology of these diseases
and develop therapies that will be translated into improved health outcomes for children across Ontario, Canada and
throughout the world.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The Hospital for Sick Children
Dr. Ramune Pleinys, Director, Research Opperations
Phone: (416) 813-5997
E-Mail: ramune.pleinys@sickkids.ca

Lead Researcher(s): Sergio Grinstein, Peter K. Kim
A multi-user facility for super-resolution microscopy
This is an application for the purchase of equipment that will constitute the core of a multi-user facility for advanced
imaging of biological samples by fluorescence microscopy methods developed in the last few years. The new
technology, called “super-resolution microscopy”, represents a quantum leap in the field of biomedical microscopy and
is now an essential tool in research. Just as importantly, the methodology is moving towards becoming the standard in
clinical diagnostic laboratories in the near future. For these reasons, it is imperative to make super-resolution
microscopy available to Ontario scientists and doctors as soon as possible. Remarkably, no such equipment is
currently available for use by the Ontario biomedical community.

The Imaging Facility operated by the Hospital for Sick Children, established over 10 years ago in part with CFI and
provincial funds, currently offers a range of modern optical techniques to any and all members of the local biomedical
community and also to industrial concerns and to researchers from universities elsewhere in the province and from
other provinces as well. The Facility currently serves over 600 users from over 140 different laboratories. It therefore
seems like the ideal venue to house new super-resolution microscopy equipment and would be a valuable ongoing
investment for the Province.

For over 100 years, optical microscopy was limited by the diffraction of light caused by lenses and prisms. This
inherent property of light passing through media of different refraction index causes dispersion of photons with the
inevitable loss of sharpness and definition of images. The resolution of the images becomes limited by what is known
as the “point-spread” of light. As a result, structures with diameters lower than half a micron cannot be resolved.
Because virtually all molecules and macromolecular assemblies are smaller than half a micron, conventional optical
microscopy has thus far been unable to visualize them in isolation, especially in live cells.

The limitation imposed by the point spread of light was recently overcome by several striking developments in the areas
of photophysics, photochemistry and computational biology. Five cutting-edge techniques, collectively known as super-
resolution microscopy, now offer the ability to visualize biological (and other) structures with up to 10-fold greater
resolution. These are photo-activated localization microscopy (PALM) and the related stochastic optical reconstruction
microscopy (STORM), stimulated emission depletion (STED), ground-state depletion illumination microscopy (GSDIM)
and structured illumination microscopy (SIM). Each one of these has unique advantages and limitations that must be
considered when assembling a facility intending to service a large community of scientists and doctors. To this end,
personnel managing the Sick Kids Imaging Facility have, during the course of the past 16 months, traveled to five
different locations across North America to personally test and assess the different technologies and suppliers. Based
on this thorough assessment and after extensive consultation with the prospective users, we have chosen to combine
PALM and SIM to acquire maximum resolution and flexibility.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The Hospital for Sick Children
Dr. Ramune Pleinys, Director, Research Opperations
Phone: (416) 813-5997
E-Mail: ramune.pleinys@sickkids.ca

Lead Researcher(s): Stephen W. Scherer
The Centre for Applied Genomics: Paediatric Genomes to Outcomes
The infrastructure requested here will build on capacity in the established Science and Technology Innovation Centre at
The Centre for Applied Genomics, located within The Hospital for Sick Children (SickKids) in Toronto. TCAG
(www.tcag.ca) has grown into a multi-million dollar Genome Centre (Figure 1 below) and has been continuously funded
as the Ontario Genomics Institute centralized infrastructure platform since Genome Canada’s inception in 2001. Adding
to this base, TCAG has also been funded by other partners including both CFI and Ontario initiatives such as the
Ontario Research and Development Challenge Fund (ORDCF), Ontario Innovation Trust awards, and investments from
the Ontario Research Fund. The centre is broadly enabling to Ontario-funded researchers, including for example eight
ORF-GL2 projects currently running that requested TCAG support and services, and two Ontario Brain Institute grants.
This proposal builds directly on two CFI projects that are co-funded by the Province of Ontario, namely the LEF project
#20564 (Integrative Genomics for Health Research – Phase II) to Dr. Steve Scherer, and the Research Hospital Fund
project #15939 (The SickKids Child Health Research Institute) to Janet Rossant/The Hospital for Sick Children
Research Institute. In August of 2011, the Government of Ontario announced a $75 million investment towards this
latter initiative. TCAG will be a cornerstone of the new institute. With this project, we seek to increase TCAG’s capacity
for genome sequencing, supporting a new, large-scale sequencing project in paediatric genomics, and numerous other
related initiatives. The large-scale project proposed here that will use the infrastructure will be a clinical research project
comprised of sequencing paediatric DNA samples primarily ascertained at SickKids and at Holland Bloorview Kids
Rehabilitation Hospital, as well as from other collaborators. This research will broadly focus on identifying genetic
contributions to disorders such as the epilepsies, autism, intellectual disability, ADHD, bipolar disorder, and other
paediatric mental health and neurodevelopmental conditions. The project represents collaboration spearheaded by a
new hospital-based Genetics Centre at SickKids, the University of Toronto based McLaughlin Centre, and international
collaborators such as the National Institutes of Health Autism Sequencing Consortium, the Wellcome Trust Sanger
Institute, the Beijing Genomics Institute, and others. The infrastructure enhancements proposed here will also be critical
for the ongoing success of large-scale Ontario-funded projects such as the ORF-GL2 project Autism Spectrum and
Associated Neurodevelopmental Disorders: Genomes to Outcomes, and the Ontario Brain Institute’s Province of
Ontario Neurodevelopmental Disorder (POND) Network, both of which are ongoing at TCAG.

Specifically, we are requesting here two next-generation DNA sequencers for whole-genome discovery research, a
smaller next-generation sequencer for targeted discovery and translational diagnostic test development, and a
genotyping system for high-throughput validation across large patient and control cohorts. Data emanating from these
studies will allow for better diagnostic stratification of patients, and will thus feed forward into clinical trials design and
implementation beyond the lifetime of this project. Concomitant with these activities will be research into potential
impacts of whole genome sequencing, and the ethical issues surrounding the use of these data.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The New Women's College Hospital
Dr. Terri Myhr, Director, Research Operations
Phone: 416-351-3780
E-Mail: Terri.myhr@wchospital.ca

Lead Researcher(s): Steven A. Narod
Center for Molecular and Epidemiologic Studies of Hereditary Cancers in Women
The mission of the Center for Molecular and Epidemiologic Studies of Hereditary Cancers in Women (MESH) is to
generate a comprehensive knowledgebase of hereditary cancers to further our understanding of the means to identify,
prevent, manage and treat women at-risk using a rapid, efficacious, and personalized approach. Ultimately, our goal is
to reduce hereditary cancer cases in women in Ontario, Canada and the world. For this, the WCRI has assembled a
multidisciplinary team of talented and motivated researchers with exceptional expertise in epidemiology, cancer biology,
molecular and population genetics. Led by Dr. Steven Narod, this team of distinguished scientists will carry out the
objectives of this proposal aimed at expanding and intensifying our current program of research which includes one of
the world’s largest databases of more than 55,000 biological specimens (including over 12,000 BRCA1/2 mutation
carriers) from more than 70 centres worldwide. It consists of DNA samples, tissue specimens, family pedigrees, clinical
details and epidemiologic data and has resulted in over 500 peer-reviewed publications. The requested infrastructure
will enable us to increase and enhance the capacity of our current program to perform more comprehensive analyses of
our current and future biological samples. Moreover, we will be in a superior position to identify at-risk individuals,
understand the etiology of their respective cancers, and to provide personalized cancer prevention and treatment
strategies.

The MESH team has over 15 years of experience in studies of hereditary cancers. With this proposal, we plan to
intensify and expand the capacity of our current genetic testing platforms, to allow for large-scale population-based and
genome-wide genetic and epigenetic studies. For this, we intend to acquire high-throughput genotyping and
sequencing instruments, and automate many of our routine and labour intensive laboratory procedures. We also aim to
complement our program by investigating the cellular and molecular consequences of newly discovered hereditary
mutations. An upgraded research laboratory will allow us to provide rapid turnaround of genetic test results which will
enable us to do interventional studies using genetic information. Importantly, we will also be able to attract more
international collaborations, including many developing countries, to further expand our already ethnically diverse bio-
repository. Such an expansive and genetically diverse bio-repository of biological specimens will allow us to conduct
unique large-scale studies that can inform and reflect the ethnically diverse population in Ontario.

In summary, with the infrastructure proposed, in addition to the world-leading achievements of our current team in the
field of hereditary cancer, a continuously expanding bio-repository of over 55,000 biological samples, and a network of
national and international collaborators, we will have an excellent setting to conduct our unique and ambitious research
program. Acquisition of new instruments and the launching of new endeavours will increase our already proven
leadership in this field. As a result, our efforts will help us to decrease the incidence and mortality associated with
hereditary cancers among women worldwide.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Blaine A. Chronik
Centre for the development and testing of MR-compatible medical devices and
technology
We are proposing to establish a comprehensive facility in Ontario for the research and development of Magnetic
Resonance (MR)-compatible medical devices. Examples of devices which are of major interest are: pacemakers,
neurostimulators, cochlear implants, surgical robotic systems, orthopaedic implants, and patient monitoring devices.
We have a comprehensive installation of MR scanners, across all relevant field strengths (from the dominant clinical
field strengths of 1.5T and 3T, to the emerging 7T systems for human use, of which we have the only installation in the
country). However, in order for us to understand and develop MR-compatible medical devices, we must have the
capacity to:
(1) recreate aspects of the MRI system which affect medical devices, but in the controlled environment of our
laboratory;
(2) conduct careful measurements of device operation and reaction to these environments;
(3) develop and demonstrate a complete understanding of these interactions and how to manage them. The creation of
this first-in-Canada testing and development laboratory, taken in combination with the full range of MR systems already
installed and available at our site because of past CFI and ORF investments, will result in an unrivalled capacity for
medical device development. Our vision is to be the partner of choice for researchers and companies anywhere in the
world for MR-compatible device development and testing.

Our specific objectives are:
• create a comprehensive laboratory testing facility (including radiofrequency exposure, audiofrequency (i.e. gradient)
field exposure, mechanical vibration and force testing, and tissue-mimicking materials characterization and testing)
within Ontario for the research and development of medical devices for use within MR systems;
• to encourage and support academic research in the development of MR-compatible medical devices;
• to development and expand existing industrial collaborations in MR-compatible medical device development at
Western;
• to establish “The Centre for the Development and Testing of MR-compatible Medical Devices and Technology” as a
Western centre for attracting and supporting increased industrial collaboration in MR device testing, for companies
developing MR-compatible medical devices.

The major equipment to be purchased are:
• Electromagnetic (RF and gradient field) exposure and measurement system ($1,170,000). This consists of: (1) a 63
MHz radiofrequency exposure system (amplifier, control, and resonant coil) which mimics a 1.5T MR environment; (2) a
127 MHz radiofrequency exposure system which mimics a 3.0T MR environment; (3) a gradient-field exposure system
which can reproduce the audiofrequency (kHz) fields produced in any MR environment from 1.5T to 7.0T; (4) a highly
accurate robotic positioning system (the DASY52 NEO scanning system) for semi-automated measurement and
mapping of all fields during testing.
• Biomaterials test and measurement system ($180,000). This rheometer platform will provide accurate measurements
of the viscous and elastic moduli and the yield stress of the tissue-mimicking gels as functions of sample age,
temperature, and preparation method.
• Mechanical vibration and force measurement system ($120,000). This dynamic signal analyzer will allow
comprehensive measurements of potentially damaging MR-induced vibrations and forces on medical devices within
existing MR scanners (from 1.5T to 7.0T).
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Stephen Ferguson
Super-resolution and intra-vital imaging of cell signalling complexes in Multiple
Sclerosis and Alzheimer's disease
Research/Technology Development: Ontario is a long established leader in the field of Neuroscience, and our research
team will integrate nationally unique expertise in molecular imaging, cell biology, immunology, surface science
technology and mouse models of Multiple Sclerosis (MS) and Alzheimer’s disease (AD). We propose to develop super-
resolution and state-of-the-art deep tissue (intra-vital) multiphoton imaging technologies to perform discovery-based
research that permits the visualization of perturbed cell signalling events and cell interactions that underlie MS and AD
pathophysiology. These innovative imaging technologies will build upon previous CFI/ORF funding in molecular
imaging at Western/Robarts and will permit our research team to translate what we learn about altered cell signalling at
super-resolution (a microscopic resolution that will exceed existing light microscopic technologies by 10 fold) to cell-cell
interactions in MS and AD mouse models. The requested infrastructure will allow:
1) the discovery of novel mechanisms contributing to the pathology of neurodegenerative disease at a resolution that
was not previously imagined and
2) the ability to assess the outcomes of experimental manipulations and clinical interventions at molecular, cellular, and
tissue-levels instead of relying on traditional conventional clinical measures. This will position Ontario as a world leader
in molecular neuroscience discovery research, and neurodegenerative pharmaceutical research that directly assesses
the impact of therapeutic interventions on disease affected tissues. Furthermore, this will significantly enhance our
capacity to screen, develop and validate novel therapeutic modalities for the treatment of MS and AD.

Requested Infrastructure:
The requested infrastructure includes the following:
1) A super-resolution microscope providing sub-light optical resolution (20-80 nm) and the simultaneous detection of six
distinct proteins.
2) An upright multiphoton confocal microscope specifically adapted/dedicated for intra-vital microscopy.
3) A microscope (e.g. Leica TCS SP5 II VIS/STED) integrating super-resolution with multiphoton imaging.
4) A super-resolution confocal microscope (e.g., Zeiss LSM780 Elyra PS1) permitting both user-friendly confocal and
super-resolution imaging of protein-protein interactions in living cells.

The microscopes will be supported by a viral vector facility (allowing the development of fluorescently-tagged proteins
for viral infection of neurons, brain slices and mice), as well as computational and data storage backup.

Benefits to Ontario: AD and MS currently cost the Canadian economy $16 billion per year and for AD alone this cost is
estimated to rise to $153 billion by 2038 (40% of this cost will be realized in Ontario). The requested infrastructure will
facilitate our research team’s investigation of cell signalling mechanisms that are changed in MS and AD at the cellular
level. This research will ultimately utilize ORF-funded drug discovery platforms to screen for small molecule inhibitors to
block pathological protein and cellular interactions in MS and AD. The proposed infrastructure, combined with the
unique expertise of the applicants, will facilitate the training and retention of the next generation of highly-qualified
personnel (HQP) who will enhance the research profile and identify Ontario as the world leader in molecular imaging
and neurodegenerative research. Our goal is to reduce the burden of neurodegenerative disease on Ontario’s
economy, society and health care system through research.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Amit Garg
ICES@Western: Enhancing Innovation for a Provincial Health Services Research
Network
World Class Research Innovation

Through a previous ORF investment in 2000, ICES has become Canada’s premier institute for health services research
and clinical evaluative studies. ICES's anonymous linkage of vital statistics, physician billings, and health services data
for all Ontario citizens provides an unprecedented international resource to study health care. ICES created a strong
core in Toronto that permitted support of ICES satellites in neighbouring cities. ICES@Western satellite is being
pursued through this ORF-LIF to be developed in London.

ICES@Western will be unique among existing satellite units and will significantly advance ICES research through the
following initiatives:
1) ICES’s 6th pan-Ontario research program (Kidney, Dialysis and Transplantation) will be launched at ICES@Western.
Additional kidney function data will be linked to the ICES data to support this program and to pursue research in priority
areas: to prevent transplant waiting list deaths, increase the life span of patients with kidney failure (currently worse
than most cancers), and keeping populations healthy by preventing kidney failure.
2) ICES@Western will be the first and only ICES site to have an adjacent biorepository for storage of patient DNA,
blood, and urine samples linked to ICES health care databases.
3) ICES@Western will significantly expand ICES capabilities and data holdings. Expansions of existing linkages include
hospital drug use, pathology, imaging, and medications for all ages. New data linkages will be established including an
electronic medical record database for diabetic patients and a mental health database focusing on homeless
individuals. 4) A partnership between “CSTAR” (Canadian Surgical Technologies and Advanced Robotics) and
ICES@Western will allow novel research studies to be conducted on patient outcomes of new health technologies.
5) World-class biostatisticians at The University of Western Ontario are advancing research methodology that can be
applied to, and advanced by, ICES@Western research.

Equipment Required for Secure & Privacy Compliant Facility
The ability to conduct ICES@Western research is dependent upon a secure and privacy compliant facility.
ICES@Western will require high performance computational and security-specific equipment to provide secure access
to ICES data. ICES@Western is a cross-faculty initiative that will empower research across 7 locations at the university
and teaching hospitals by creating computer nodes across these sites where investigators and trainees can work with
aggregated, anonymous data. The nodes will provide dedicated workstations (with necessary computational
equipment, software, and network printers) to connect researchers and trainees with ICES@Western. Additional
equipment is also required for the adjacent biorepository to increase storage capacity.

Exceptional Benefits for Ontario Innovation
ICES@Western will accelerate Ontario’s goals of becoming a global leader through the following priority areas:
Economy:
1) Implementing a cost-effective health care system
2) Creating a whole new level of research and design
3) Shaping worldly researchers through training and introducing job opportunities
Health:
1) Optimizing patient care
2) Accelerating health care advancements
3) Validating state-of-the-art health technologies
Research & Design:
1) Being a global leader in health services research
2) Strengthening an existing high profile network
3) Performing novel evaluations of health technologies
4) Pharmaceutical advances for drug safety and policy
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Christopher G. Guglielmo
AFAR takes flight: new field technologies to study global-, regional-, and local-scale
movement ecology of free-living birds
The research will capitalize on recent technological advancements to completely transform the way we study highly
mobile animals. Movement is a fundamental ecological process, and movement behaviour varies from small changes in
position within a home range to awe-inspiring migrations across the face of the Earth. Our team will use space and
ground-based telemetry, stable isotope markers in feathers, and innovative radar systems to study the mechanisms
underlying movement decisions of birds at all spatial scales, and the population genetic, demographic and
epidemiological effects of different movement phenomena. We will also conduct fundamental experiments addressing
inter-seasonal (‘carry-over’) effects of stressful migration on reproduction and of stressful reproduction on migration.

The major equipment purchased will include: (1) ICARUS International Space Station global tracking transmitters, (2)
two state-of-the-art mass spectrometers devoted to analyzing stable- H, O, C, N and S isotopes in migratory birds, (3)
digital telemetry arrays of 50 – 100 automated receivers for local-scale tracking of radio-tagged birds to within meters
and regional-scale tracking over hundreds of kilometers, (4) digital radars for measuring numbers and flight
characteristics (altitude, speed, bearings) of unmarked birds in the atmosphere, (5) harmonic radars to measure
detailed flight characteristics of individual birds marked with $1 transponder tags, (6) large outdoor aviaries for studies
of birds under semi-natural conditions, (7) a quantitative magnetic resonance body composition analyzer for non-
invasive physiological studies, (8) two vehicles for radio tracking, and (9) minor renovations to animal care and
research space.

The infrastructure will firmly establish Ontario Universities and Canada as global leaders in migratory bird research with
(1) the North American hub for tracking small individual birds across the globe with the new ICARUS system based on
the International Space Station, (2) the first stable isotope facility in the world dedicated solely to documenting the
movements of migratory birds across international borders, and (3) innovative local- and regional-scale automated
telemetry arrays to track movements of birds with unprecedented detail. The infrastructure will allow us to achieve our
primary goal of understanding the demographic connections between breeding, migrating and wintering locations for all
of Ontario’s and Canada’s birds by 2030.

The project will provide many important benefits to Ontario and Canada in the areas of biodiversity conservation,
environmental quality, arctic and boreal studies, economic development in the energy sector, social values, human
health, and training of highly qualified personnel. Approximately eighty percent of Canada’s bird fauna is migratory.
Many species have been declining for decades, yet we still do not understand the causes and mechanisms of these
declines. The new infrastructure will make it possible to track movements of birds in great detail. The baseline data
created will be critical to understanding how changes in climate will affect movements of animals and the associated
impacts to ecosystems and biodiversity. Detailed tracking of birds (and bats) across the landscape and in the
atmosphere will facilitate the safe and cost-effective development of wind energy. Understanding of bird dispersal and
migration will enhance models and planning for the spread of bird-borne zoonotic diseases.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): David W. Holdsworth, Trevor B. Birmingham, Cynthia E. Dunning
Facility for load-bearing imaging, biomechanics and clinical orthopaedics research
Introduction: Bone and joint disorders are the leading cause of disability in Canada, affecting over 1.6 million
Ontarians and costing the Ontario economy over $2 billion annually. Bone and joint disorders include arthritis,
osteoporosis, trauma, sport- and work-related injuries, among others. Although these disorders vary considerably in
their manifestation and proposed treatments, they all affect specific anatomical structures, leading to painful limitations
in the way we load and move our bones and joints. Advanced imaging techniques provide the capability to study and
quantify specific, detailed anatomical structures, but until recently, have been limited to non-weightbearing, static
positions that do not represent how bones and joints function. Recent developments in imaging technologies now
provide the opportunity to overcome those shortcomings.

Research Plan: We propose to develop a facility to obtain and apply different modes of imaging bones and joints
during functional conditions of loading and movement. We will develop methods to efficiently combine data from
Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and Dynamic Radiostereometric Analysis (RSA) to
obtain highly accurate and functionally relevant images of multiple anatomical structures. The unique feature of the
proposed infrastructure is the ability to obtain quantitative images of the skeleton under weight-bearing conditions
(using open MRI and standing CT), and during normal movements (using dynamic RSA). Importantly, we will develop
methods for routine use of these multi-modal images by a team of interdisciplinary researchers to answer
biomechanical questions and evaluate clinical interventions. These images will prove to provide more valid inputs in
biomechanical models and more sensitive outcome measures in clinical trials.

Infrastructure: Our facility will incorporate state-of-the-art equipment for load-bearing imaging of joints, combining an
open upright MRI scanner to image soft tissues (such as ligaments, tendons, and cartilage) with a new type of cone-
beam CT scanner, which can produce images of the bones in the upper and lower limbs while under load. This
equipment will be integrated with the latest digital x-ray imaging technology and optical image tracking to produce
dynamic images of joints moving under load, allowing us to measure the functional anatomy, motion patterns and
internal stresses of healthy and diseased joints.

Benefits to Ontario: A focus of the research will be the development of complex biomechanical models to better
understand bone and joint disorders and their treatments. Another focus will be the incorporation of imaging measures
as additional outcomes in rigorous clinical research designs that directly compare the effects of different surgical,
medical, rehabilitative and exercise interventions. The infrastructure will form a core facility in one central location on
the main campus of The University of Western Ontario. The facility will be readily accessed by several scientists and
clinical researchers – including their students and clinical trainees – in the Faculties of Medicine (including Robarts
Imaging), Health Sciences and Engineering. The Facility will be in very close proximity to the internationally renowned
Fowler Kennedy Sport Medicine Clinic, Hand and Upper Limb Centre, and London Health Sciences Centre – serving
tens of thousands of Ontarians with bone and joint disorders yearly.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): François Lagugné-Labarthet
Facility for Nanoscale Surface Patterning: Tuning the Optical and the Electronic
Properties of Materials.
Research/Technology development: Rapid developments in the application of nanosized materials to devices such as
biological sensors, light emitters, or flexible photovoltaic will drastically change tomorrow’s technology with smaller,
faster and more energy efficient devices. Nanotechnology is revolutionizing the conception of functional devices by
assembling nanomaterials with extreme precision and exploiting the unique properties of these materials in response to
mechanical, electrical or optical stimuli. By providing a coherent ensemble of nanotechnologies that will offer new
solutions for the specific fabrication of complex functional devices for renewable energy and biosensing applications,
the requested infrastructure will position Ontario among the world leaders in these two competitive fields building on an
established expertise in nanofabrication.

Requested infrastructure: New instruments include: (i) a nanoimprint lithography technology for the rapid and precise
positioning of nanomaterials over ensemble of electrodes, the fabrication of microfluidic chips using glass technology
as well as for the creation of plasmonic metallic nanostructures over large surface areas. Nanoimprinting will also
increase the throughput of the fabrication of arrays which is necessary for biosensing applications; (ii) a reactive ion
etching system which is required to produce three-dimensional structures with high aspect ratios and will complement
the nanoimprint lithography for the etching of residual organic materials, oxides and nitrides, (iii) a metal evaporator for
the production of pristine thin layers of a large variety of materials to fabricate micro-electrodes with controlled shapes
or optical nanoantennae made by ebeam lithography with the possibility to deposit such metals at variable incidence.
Upgrades (iv) to our existing facility are required to maintain our state-of-the-art presence in nanofabrication: new
control electronics and detectors for our crossed-beam focussed ion beam and scanning electron microscope (first one
operational in Canada in 2001) and upgrade for the sample stage of our electron beam lithography system to support
the nanoimprint lithography.

Benefits to Ontario: In an economically uncertain world, two key factors can be used to judge the visionary capacity of a
country to be a global leader: its healthcare and its energy independency. Canada currently ranks among the top
countries in both of these aspects, yet it will be challenging to maintain this position in a fiercely competitive global
environment. Clean and/or renewable energies as well as healthcare monitoring using personalized medical portable
devices are emerging fields that require significant investment. Much research is still needed to develop highly efficient
sources of energy and high signal-to-noise detection in specialized handheld health monitoring units and the requested
infrastructure will have a significant impact on our ability to make progress in these areas. The requested infrastructure
combined with an exceptional group of physicist, chemists and engineers working in nanosciences and
nanotechnologies will create a state–of-the art training facility for highly qualified personnel working in a
multidisciplinary environment. These researchers will enter the Ontario economy and will be a key source of knowledge
and experience that will drive the evolution and growth of nanotechnology in the private and public sectors for many
years in the future. They will help to identify Ontario as the world leader in Nanotechnology.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Mellissa Mann, Victor Han, Robert Hegel
Epigenetic Determinants of Children's Health: From Bench to Playground
Following mapping of the 25,000 genes in our human genome, it became apparent that differences in genomic
sequences cannot explain the causes of many common diseases. It is now clear that genes are finely choreographed
to turn “on” and “off” in specific cells at specific times in the body. This is achieved through naturally occurring marks on
the DNA called “epigenetic” information. Different epigenetic patterns dictate whether a gene is active or silent, making
genetically identical cells different from one another. Epigenetic marks are involved in every stage of the life cycle from
eggs and sperm, embryo and fetus, to childhood and adulthood. They are particularly important for child health, since
changes in the environment can cause epigenetic errors in vulnerable populations (embryo, fetus and children). During
critical times in development, cells use epigenetic information to ‘memorize’ their exposures to environmental
pollutants, stress, or nutrients, which may then lead to paediatric physical and mental disorders as well as diseases
such as diabetes, hypertension and cancer in childhood and adulthood. Furthermore, complex behaviours such as
depression, drug addiction and suicide may have epigenetic origins, as changes in the social environment (e.g. abuse)
or physical environment (e.g. pollution) may epigenetically alter brain development in infants and children. Therefore,
defining these epigenetic patterns will explain how the environment impacts human health and disease. Our proposal
involves a team of high-achieving researchers with expertise in epigenetics, who have made a global impact through
their leading edge research in epigenetics, environment and health. We will investigate the effects of environment on
epigenetic gene regulation during vulnerable periods of embryonic and childhood development. To this end, we require
the following state-of-the art infrastructure:

(1) The OMX V4 Blaze super-high resolution imaging system, a ground-breaking, technological advancement in cellular
imaging, which will be unique to Ontario and Canada. This tool offers a critical resource for super high-resolution
imaging, beyond conventional microscopy, of chromatin and epigenetic marks at a nanoscale level;
(2) the Diagenode Bioruptor and real-time PCR with CFX robotic system for high throughput gene expression studies
and mapping of epigenetic marks on specific genes, and the dual microinjection workstations to precisely introduce
reporter constructs and environmental stressors into animal embryos to define how environmental contaminants alter
gene activity and biological pathways;
(3) the Illumina next generation DNA sequencing system to obtain detailed and comprehensive profiles of genome-wide
gene activity and epigenetic modifications; and
(4) the Geographic Information System server and workstations to identify environmental hotspots in Southwestern
Ontario that affect children’s health which can then be tested in our animal models for environment-induced epigenetic
changes. This infrastructure will provide innovative training for 45 graduate students, 5 postdoctoral fellows, and 10 full-
time technicians, producing the next generation of excellent researchers and innovators in one of the most exciting and
impactful fields of biomedical research. It will also generate world-class research that will lead to new strategies to
reduce disease risks in Ontario’s children and minimize life-long health care costs.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Ravi Menon
Centre for Functional and Metabolic Mapping
The 3 Tesla (T) Siemens Tim Trio and the 7T Agilent/Siemens MRI systems in the Centre for Functional and Metabolic
Mapping (CFMM, http://cfmm.robarts.ca/) have a distinguished lineage that extends back to the successful 2001
CFI/OIT grant, “Centre for Brain and Mind: A Facility for Primate Neurophysiology and Neuroimaging”, which provided
major upgrades to Canada’s first high-field MRI (est. 1996) and the establishment of a non-human primate (NHP)
facility in proximity to the MRI systems. These 3T and 7T human MRI systems are part of an internationally renowned
facility that has served the neuroimaging needs of over 100 principal investigators across southern Ontario as well as
those of many provincial, national and international researchers and companies. The CFMM put Ontario and Canada
on the map for high field functional MRI (fMRI) and remains the only such MRI cluster in Canada. Although the current
MRI field strengths in the CFMM will remain cutting-edge for much of this decade, the electronics that control the data
acquisition and processing (“the MRI console”) are constantly evolving. Upgrading to the next generation of MRI
consoles will allow for faster image acquisition with higher signal-to-noise, permitting us to translate our past research
successes to challenging patient and subject groups that could not otherwise be studied (see next section).

Additionally, our work in the development and testing of new MRI-compatible medical devices requires that we maintain
access to the most state-of-the-art high-field MRI systems available. Our industry partners in Ontario and elsewhere
need to demonstrate the safety of their devices on the newest clinical-calibre MRI systems (3T) as well as future clinical
platforms (7T). For example, the development of MRI-compatible Deep-Brain Stimulation (DBS) is of major importance
to understanding and optimizing the underlying physiological processes for the alleviation of Parkinson’s tremor. With
the proposed upgrades, we will be uniquely equipped to address the relevant neuroscience, device validation and
application in patient groups of devices such as DBS. Currently there are no other MRI device testing facilities in
Canada, and less than a handful worldwide, making the CFMM a preferred site for such testing by multinational medical
device companies. Similarly, we have the only human 7T MRI system in Canada. As a result many Ontario companies,
such as Northern Digital Inc. (Waterloo), Trudell Medical (London) and Profound Medical (Toronto), as well as
international corporations such as Siemens (Germany) and Boston Scientific (USA) partner with us. This allows first-in-
human applications for Ontario patients and the potential for MOHLTC to evaluate technology and therapeutic efficacy
ahead of other jurisdictions. Such factors are strong drivers of private sector investment in the province.

The requested infrastructure is organized as follows: 3T suite ($2.4M)
(a) 128 receive channel Tim 4G upgrade to Siemens 3T Tim Trio: $1,000,000
(b) 3 years service contract/software upgrades on 3T: $600,000
(c) Pediatric incubator and monitoring equipment: $400,000
(d) Adult and pediatric Radio Frequency (RF) coils: $400,000

7T suite ($2.73M)
(a) 128 receive channel, 16 transmit channel Agilent/Siemens 7T upgrade: $2,100,000
(b) 4 years service contract/software upgrades on 7T: $630,000
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Tim Newson
A Scaled Physical Modeling Facility for Energy Geotechnics
The proposed infrastructure will create a unique, world-leading scaled physical modeling facility for energy geotechnics
research. The state-of-the-art facility will consist of a geotechnical drum centrifuge and a large wind-wave sediment
flume located in the Boundary Layer Wind Tunnel laboratories of the University of Western Ontario. The requested
infrastructure has been divided into six inter-related items: modular centrifuge, wind-wave flume, data acquisition and
analysis system, project coordinator, analytical software and laboratory renovation. The state-of-the-art facilities will be
located in a dedicated research space for the centrifuge and wave-wind flume, with a control room and zones for model
and equipment preparation, testing, storage, image analysis and data processing.

The drum centrifuge consists of a 360 degree drum channel that is 0.4 m deep by 6.9 m long and 0.7 m wide with a
diameter of 2.2 m. The drum is mounted via a central shaft on a base-slab mounted pedestal, which is powered by a 55
kW motor to create horizontal rotation and a ‘hypergravity’ environment up to 200 times normal gravity. This
infrastructure will enable researchers to create small, scaled physical models of real geotechnical structures and
systems, such as deep and shallow foundations, buried structures, slopes and pipelines. The rotation of the drum
creates greater material self-weight forces in the models enabling researchers to accurately reproduce full-scale
structures and processes at reduced scale. Novel actuator systems will be designed to allow simulation of shallow fluid
waves, wind forces and earthquake loading on energy structures and soils.

An existing coupled wave flume and wind tunnel system in the Boundary Layer Wind Tunnel laboratories giving
combined random wind and wave loadings will be refurbished. The wave tank is 2m deep, 5m wide and 50m long, and
has a beach to minimize the reflection of waves. The wind-wave sediment flume would enable scaled structures and
foundations to be subjected to combined wind-wave loading (scaled wave heights of 15m and wind speeds of 30m/s)
and wind-fluid-soil-structure interaction to be investigated. This facility would suit deeper water models (with scaled
depths of 40-200m) and would enable models of the behaviour of floating and fixed offshore infrastructure, such as
tension leg platforms, SPAR buoys and wind turbines, deeper water gravity platforms and jackup rigs, and larger scale
buried pipelines to be investigated. Both the centrifuge and wind-wave flume will be equipped with state-of-the-art
instrumentation systems and digital cameras to measure stresses, pressures, and displacements in the models and to
permit soil and fluid velocity/deformation analysis.

During the first 5 years of the proposal, the new infrastructure will enable work on unique geotechnical energy research
projects, which are not able to be undertaken elsewhere in the world. Unfortunately, there is a lack of knowledge of
many of the underlying scientific processes involved in these problems, and of the engineering design and construction
techniques required to mitigate their effects. These projects are needed to sustain vital energy infrastructure in Ontario,
enable full development of Ontario’s green power generating capacity and to mitigate the effects of natural disasters on
energy infrastructure. Ontario society is currently facing enormous challenges dealing with the combined effects of
aging structures, climate change and natural hazards on the critical infrastructure that supply our basic services and
deal with the procurement of sufficient energy sources.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Dugan O'Neil
Compute Canada: Secure Computing, Data Intensive Computing & Cloud Services
Currently, Compute Canada manages several large data centers that provide access to a variety of computational
services and infrastructure. Since installation of NPF funded systems, needs of non-traditional High Performance
Computing (HPC) clients have grown dramatically. In many respects these needs are best served by computing
methodologies that are either insufficient within the current stable of Compute Canada resources or are not represented
at all. The proposal extends the capabilities of the platform in three principal dimensions: secure computing; data-
intensive computing and cloud services. Each of these components, together with the principal research areas to be
enabled, will be described below. As with all almost all infrastructure in the platform, the resources support a huge
number of users and disciplines – this sharing is, of course, a key benefit and efficiency of the platform – and some of
these other activities will be noted as appropriate.

Secure Computing: There are several emerging HPC client communities that require a secure computing environment.
They are typically required to work within security guidelines imposed by their data providers. These guidelines can
vary substantially from provider to provider. Examples include: health data provided by hospitals or provincial health
ministries, crime data provided by the RCMP or other police forces, and proprietary commercial data from a number of
sources. Each of these examples is taken directly from Canadian university researchers as part of our LEF
consultations. Compute Canada provides the most cost-effective way to serve the secure computation need for a
diverse array of research projects. Addressing these needs may require dedicated standalone equipment in a
physically secure environment with severely controlled network connectivity to levels of security that meet regulatory
standards for the health sector: standards much higher than is usual practice in most academic research. In Ontario it is
proposed to extend capabilities for secure health data and medical records.

Data-Intensive Computing: The exponential growth in data, driven by next-generation DNA sequencers, MRIs, CCD
cameras and other detectors promises to revolutionize our knowledge across a wide range of disciplines including
genetics, bioinformatics, medical imaging, business analytics, astronomy and more. These applications typically
demand very large storage systems directly connected to a large computational resource if the vast amount of data is to
be effectively analysed. Recent dramatic growth in computationally-intensive health research in many areas (e.g.
bioinformatics, DNA sequencing and processing of high resolution medical images) has already placed severe
demands on Compute Canada resources to the extent that this general area is rapidly becoming poorly served. The
problem only worsens with time. The absence of the appropriate resources within Compute Canada is a significant
disincentive for these Big Data communities to connect closely to the national platform. However, it is clear that
Compute Canada has the HPC expertise in terms of hardware and software to be able to develop, install, promote and
efficiently utilize new platforms specifically designed for data-intensive research. The proposal will increase the storage
attached to Ontario’s largest HPC system by 3-5Pb.

Cloud Services: Integrating non-traditional HPC researchers from the health and social sciences requires investing in a
better way to support these clients. The proposed Compute Canada cloud would provide a variety of new resources
and services, with particular benefit to those who may require specialized operating environments or software
interfaces which abstract the user from the underlying hardware. The infrastructure would enable/accelerate research in
bioinformatics, by the medical community, in some engineering disciplines, in the social sciences, and in the digital
humanities. We propose a hardware solution that will provide a scalable cloud with an initial size of approximately
15,000 cores.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Gordon R. Osinski
EXPLORE: The Laboratory for Earth and Space Exploration
The goal of this proposal is to establish a new facility – EXPLORE – dedicated to the development and application of
technologies and techniques for Earth and space exploration and the analysis of Earth and planetary materials.
EXPLORE will be the first of its kind in Canada. It represents a collective effort to form a strategic partnership between
industry, academia, and government centred around the themes of Earth and planetary exploration, mining technology,
and robotics. This focus on the exploration of remote, extreme environments – whether they be in the Canadian Arctic,
in deep underground mines, or on other planetary bodies – is science-driven but technology-enabled and requires, as
never before, the increased collaboration between scientists and engineers, academia, industry and government.

The EXPLORE facility will support four core areas (themes) of research– these themes are all interlinked, interactive
and iteratively feed into one another:
1. Earth and planetary materials research.
2. Mechatronic tools for materials handling.
3. Imaging and analysis instrumentation.
4. Exploration surface systems.

EXPLORE will feature 5 integral suites of instrumentation and technologies:
1. Mobile Geological Laboratory Suite – This suite of field portable instruments will revolutionize the research programs
of this research team by allowing analyses to be conducted in situ in the field, thus maximizing the scientific return from
fieldwork, particularly in remote environments.
2. Imaging and Analysis Laboratory Suite – This suite of instruments will provide a range of non-destructive
characterization analyses (mineralogy, chemical composition, 3D imaging, etc.) of Earth and planetary materials.
Research in the Robotic Engineering Facility (below) will seek to integrate these instruments with the robotics.
3. Robotic Engineering Facility – For telerobotic development, telerobotic training, and teleoperation of sample handling
and analysis of planetary and terrestrial samples. The teleoperation suite will be designed to be interfaced through
Sharcnet to enable scientists from across Canada to access the facility.
4. Field Robots for Terrestrial Exploration and Planetary Analogue Testing Facility – This proposal will see the
establishment of state-of-the-art field robot prototypes for roving long distances and exploring vertical surfaces. These
prototypes will enable new science to be conducted by providing safe field access to sites that are too risky for humans
to explore (e.g., gathering samples from loose cliff/mine faces).
5. Teleoperation and 3D Visualization Suite – The 3D visualization of data forms the core of the interpretation of
satellite imagery of remote field terrains. In addition, the ability to visualize data in 3D from the analysis of Earth and
planetary materials is increasingly being applied. This suite will allow the telerobotic manipulation of laboratory-housed
and field robot-mounted instrumentation.

The EXPLORE facility will benefit Ontario by strengthening Ontario’s economy by increasing existing research and
development, increasing industrial strength through partnerships and collaborations, and by developing new
technologies and techniques for exploration. In particular, the technology for exploration in extreme environments is
directly transferable to the mineral exploration industry. In addition, the acquisition of the requested infrastructure will
also provide significant scientific leadership opportunities, training of HQP in Ontario, and international participation in
emerging geochemical techniques.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Paul J. Ragogna
Enhancement of the Infrastructure for Characterization of Advanced Molecular
Architectures
Research and Technology Development:
The proposed infrastructure is intended to enable the advancement of research currently being conducted in two
related areas of materials science by a large number of scientists throughout the University. Research being
undertaken by the applicants not only involves fundamental chemical transformations but also a large number of cross-
disciplinary efforts - all in areas central to the strategic mission of the University. The focus of this proposal is on the
synthesis of new functional materials with applications in the energy and health sectors.

Major Equipment Acquisition:
We are seeking funds to purchase a mass spectrometer (MS), specifically a high resolution magnetic sector instrument.
The research programs described below are predicated on the synthesis of the advanced molecular architectures
which absolutely require high resolution mass spectrometry to elucidate the identity of intermediates and products and
to confirm the elemental composition of all new molecules.

The acquisition of this infrastructure will elevate our globally-recognized research in two identified signature areas:
1) new materials for clean energy production and
2) health diagnostics and biomaterials. The acquisition of this instrumentation will enable us to become pioneers in
these two areas of critical importance to Ontario.

Benefits to Ontario:
This team of researchers have an exceptional track record in scientific discovery and also in working with Ontario-
based companies. This is exemplified by their collective track record of technology transfer. Several patents and patent
applications have already been generated (11 from the groups of Ragogna, Gillies, Workentin, Charpentier and Wisner)
and have the potential to directly benefit society, particularly within Ontario, but also as a whole. More patents are
expected to arise as a result of the research described herein. The proposed infrastructure will also have important
benefits toward the training of Highly Qualified Personnel (HQP) - an immediate and tangible benefit to the province.
The co-applicants currently supervise a total of 16 undergraduate students, 56 graduate students and 11 postdoctoral
researchers as part of their ongoing research programs. Each and every HQP relies on access to the type of analysis
that the proposed infrastructure will provide. These researchers will become the next generation of highly educated
scientists for employment in the pharmaceutical, polymer, contract research, mining, analytical and medical sectors in
Ontario resulting in significant knowledge and skill transfer to the workforce for the benefit of all Ontarians. Some HQP
can be expected to join spin-off companies or start-up companies derived from the results of the innovative research
produced by the co-applicants.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Xianbin Wang, Michael Baue
Situation-Aware Adaptive Communication Technologies for Distributed IT Services
The unprecedented deployment of the massive amounts of computing and storage facilities in the last few decades, in
conjunction with the powerful and low cost broadband communications infrastructure, have led to a vast network of
geographically distributed information technology (IT) resources, which often features very low utilization of many in-
house computing facilities. On the other hand, escalating capital costs of centralized/co-located IT infrastructure, and
the associated increasing challenge for operation and maintenance, prevent many smaller organizations and
individuals from owning high end IT facilities and services.

As a result, emerging approaches to take advantage of distributed IT resources based on virtualization of computing
systems, including data center and cloud computing technologies, are currently under intensive research and
development to provide more cost-effective IT services by closely aligning of distributed IT resources with business
needs. However, the much needed technical capability to effectively explore the distributed IT facilities relies heavily on
the situation-aware coordination and reliable data exchange among such IT resources through customized
communication technologies. Unfortunately, current communications solutions involved in distributed IT services are
developed based on legacy technologies, which had evolved completely independent from these emerging applications
without considering any application specific requirements of the distributed IT services.

The fundamental goal of the proposed ORF infrastructure is to enable the leading-edge research on situation-aware
adaptive communications technologies and address the specific challenges associated with efficient utilization of
distributed IT resources. New adaptive communication paradigms with dramatically improved capability of handling
delay-sensitive and bursty traffic from distributed computing will be developed through the proposed differentiation and
prioritization of the user requests and communications resources. Communications reliability and data confidentiality of
the distributed IT networks will be enhanced through situation and user specific processing to address the security
requirements of distributed IT services. In addition, new dimensions of communication systems and network design will
be explored by improving situational awareness in coordinating the distributed computing resources for reduced
interaction delay and improved computational efficiency.

The proposed ORF infrastructure consists of facilities that fall in the following categories for new communication
technology development, prototype implementation and performance evaluation of the proposed distributed
IT/communication network, and technology demonstration in realistic application environments.

o Communications system and network design & development tools;
o Communications system testing equipment;
o Experimental communication network for distributed IT services;
o Facilities related to the realistic application environments including health applications.

The proposed ORF infrastructure will allow the researchers at Western embark on a very promising research area of
enabling the creation of customized communications technologies for distributed IT services. New communication
paradigms based on both novel architecture and standard compatible platforms for distributed IT services are to be
developed with the support of the ORF infrastructure. Technology innovations and expected transfer processes to
computing and communications equipment manufacturers and IT service providers will be accelerated with the
proposed demonstration network of distributed IT services to showcase the technologies to the potential industrial
partners. The research findings, IP creation, HQP training, and prototype development activities are expected to bring
long-term technological, economical and societal benefits to Ontario.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


The University of Western Ontario
Mr. Derek Newton, (A) Director, Research Development & Services and Ethics
Phone: 519-661-2111 x 85313
E-Mail: dnewton2@uwo.ca

Lead Researcher(s): Prudence Allen
National Centre for Audiology
The National Centre for Audiology (NCA) is an internationally recognized centre for excellence in advanced hearing
health research. Researchers lead in the development and fitting of assistive listening technologies for hearing
impaired persons, the design of better tools for evaluating hearing abilities, and advances in the science of hearing and
hearing loss.

The proposed infrastructure enhancement will allow for advances in our 3D simulation laboratories with new
multichannel sound delivery systems in our anechoic chamber. This will provide a more accurate simulation of real
listening environments. We will also develop the capacity for measuring performance in field listening environments
(e.g. classrooms and in vehicles).

Our ability to measure and understand the impact of technology on hearing and communication development will be
expanded. We will develop capacity for studying brain plasticity in both humans and animal models including cats and
non-human primates. We will develop laboratories to study cortical responses not only in anaesthetized, but in awake
animals allowing us to measure brain responses while animals are actively listening. We will establish a new
laboratory for studying children’s listening environments allowing us to better describe the hearing world of an active
child including time spent in conversation, quiet, and noise. We will develop a listening lab allowing us to observe
children’s responses to sound in real life settings. This work collectively will enable us to better understand how sound
is heard, transmitted in the brain, and used for communication thus enhancing our ability to determine intervention
needs and their efficacy.

Our work in understanding the biomechanics of the middle ear will be greatly enhanced with the addition of hearing
laser Doppler vibrometers that allow 3-D measures of middle ear movement in live, human patients. This will be a
significant improvement over our previous ability to make only 1D measurement and only in cadaveric specimens or
with synthetic material. This new capacity will improve our understanding of the very complex movement of the middle
ear, facilitate the diagnosis of hearing problems, allow testing of new models, and improve surgical outcomes for
patients with middle ear disease requiring medical intervention.

The NCA is one of the most well respected centres for hearing science and audiologic research in the world attracting
and retaining some of today’s most impressive researchers and engineers and training outstanding students in hearing
science. We work with over a dozen private sector companies in the hearing health care, communications, sound
measurement, and clinical service delivery sectors¸ many in Ontario. The NCA places Ontario in a leading position in
hearing science and audiologic research. These enhancements to our research infrastructure will ensure the NCA
continues to be on the cutting edge of hearing health care technology research, development and education.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Trent University
Mr. John Knight, Manager, Corporate Research Partnerships
Phone: 705-748-1011 Ext. 7374
E-Mail: johnknight@trentu.ca

Lead Researcher(s): Holger Hintelmann
New Horizons for Research at the Trent University Water Quality Centre and Isotope
Ratio Facility using High Resolution Mass Spectronomy
Trent University’s Water Quality Centre (WQC) is recognized internationally as a top water research laboratory in the
world. The WQC is dedicated to the development and application of innovative techniques for the study of water quality
and analysis of organic and inorganic contaminants in aquatic environments. The WQC is unique because of its range
of analytical capabilities. State-of-the-science instrumentation suitable for trace metal, trace organic, and major element
analyses equips WQC researchers for addressing virtually any water quality issue related to contaminants. A key
strength of the Centre is its expertise in using a diversity of advanced mass spectrometric equipment for addressing
complex environmental problems. The complementary array of equipment within the Centre attracts researchers from
other universities and colleges, as well as government and industry partners.
The unique facilities in the WQC place Trent as a global leader in research in the areas of environmental impacts of
pharmaceuticals and nanomaterials, tracing of metal pollution in the environment, developing new technologies to
measure radioactive elements in real-time, and estimating the efficacy of emission reduction technology. The Centre’s
impact on research and development has expanded beyond the province of Ontario to include national and
international recognition for research and innovation, as evidenced by the many collaborations with national and
international partners. With the proposed acquisition of newly-developed mass spectrometry equipment, Trent will take
another leap forward in accelerating the research capacity of current WQC users, as well as bringing in new users both
from within Trent and from beyond the institution to use the unique research tools. For example, Trent was the first
university in Canada receiving multicollector ICP/MS equipment, and we are now seeking to maintain our research
edge by acquiring even more versatile high-resolution multicollector ICP/MS, which will be entirely devoted to
environmental research.

The project is consistent with the Strategic Research Plan of Trent University, which includes a commitment to support
research in the Environmental and Natural Sciences, Aquatic Sciences and Biogeochemistry. The facilities will
complement the work currently being conducted by researchers within the Institute for Watershed Science, the
Canadian Environmental Modeling Centre, the Water Quality Centre and the academic departments of Environmental
and Resource Studies, Chemistry, Geography, Forensics and Biology. Graduate students using the facilities will be
enrolled as MSc or PhD students in the Environmental and Life Science Graduate Program. Trent collaborators and
principle users include 2 Canada Research Chairs (Tier II), 2 current or former holders of NSERC University Faculty
Awards, 2 current or former holders of Premier’s Research Excellence Awards (Ontario) and one institutional Research
Chair. In addition, three associate faculty, who are included here from other institutions are Dr. Brent Wootton, the
Director of the Centre for Alternative Water Treatment at Sir Sandford Fleming College, Dr. Doug Holdway, Professor
and holder of the Canada Research Chair in Aquatic Toxicology at the University of Ontario Institute of Technology, and
Dr. Jack Cornett, Professor and holder of the Canada Research Chair in Radiochemistry and Environmental Health
(Tier I) at the University of Ottawa
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Trent University
Mr. John Knight, Manager, Corporate Research Partnerships
Phone: 705-748-1011 Ext. 7374
E-Mail: johnknight@trentu.ca

Lead Researcher(s): Dennis Murray, Paul Wilson, Chris Kyle, Brad White
Conservation and Natural Resource Genomics: Next Generation DNA Sequencing
Trent University is recognized as a world leader in wildlife research, specifically in the realm of population and
landscape genetics and ecology and conservation biology. The next decade will oversee rapid and profound changes
in the capacity of genetics research, as it moves into the realm of functional genomics adaptation, evolutionary
responses, and speciation. Although such a research revolution is ongoing in the human medical and
domestic/livestock fields, wildlife-related research is just now starting to experience the full benefits of genomics tools
and next generation sequencing technologies. With the requested sequencing equipment, Trent University will become
the National leader in fish and wildlife genomics research and application, which is a field of investigation with extensive
implications to the welfare of society and the planet. Indeed, through rapid and ongoing changes in natural and
managed landscapes due to habitat loss, species extinctions, emerging pathogens, and climate change, it is arguable
that perhaps the most dramatic changes in the next decades will occur among natural populations including fish and
wildlife, and it is therefore imperative for researchers to understand and convey to society the coming wave of changes
and to assess the buffering potential of rapid adaptive change and the evolutionary processes by which such change is
driven.

Enhanced genomics capacity is necessary to provide a mechanistic explanation for ongoing and future patterns of
genetic change. Third Generation sequencing, through acquisition of a PacBioRS 3rd Generation Sequencer, SNP
detector, and High Performance Computational Cluster (HPPC), will provide the ability to go beyond neutral genetic
markers and allow fish and wildlife researchers to infer adaptive processes, even at the scale of molecules.
Accordingly, with the requested infrastructure the proponents will lead basic and applied research in understanding and
predicting adaptive change in natural populations in the face of climate change or population decline; this area of
investigation surpasses the development of a biodiversity catalogue, which is the current emphasis in fish and wildlife
genomics. Thus, the proposed infrastructure will provide a unique and world-class contribution to our understanding of
functionality, adaptation, speciation, and evolutionary change in fish and wildlife. For example, the equipment will be
used immediately towards understanding fundamental mechanisms underlying selection and adaptation in rapidly-
changing environments among populations of endangered caribou, wolves, lynx and whales, or selection processes in
harvested fish and moose populations. The flagship raccoon rabies program conducted by the Ontario Ministry of
Natural Resources and Trent University will be extended into the realm of adaptive change of the virus and host, as
well as similar change associated with emerging pathogens affecting fish and amphibians. Ongoing research in
fisheries stock assessment and livestock breeding also will assume a more mechanistic flavour through Third
Generation sequencing. The infrastructure also will allow more extensive tracking of individual populations for wildlife
forensics. Collectively, these and new initiatives will develop a detailed understanding of how and why fish and wildlife
populations are changing, and how they will continue to change in the decades to come.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University Health Network
Dr. Helen Chan, Research Communications Officer
Phone: (416) 946-2085
E-Mail: hchan@uhnresearch.ca

Lead Researcher(s): Shaf Keshavjee
The Organ Repair and Regeneration Centre
Organ transplantation is recognized as the most effective therapy for patients suffering from a wide range of diseases.
However, thereare many significant impediments which prevent the full utilization oforgans available for transplant.
While thenumber of patients in need of organ transplantation is increasing, thenumber of donors remains static. The
shortage is further aggravated by the very lowutilization rates of donor organs. For example, only 15% of lungs and
25% of livers, kidneys and hearts frommulti-organ donors are used for transplantation; the rest are considered
unsuitable dueto injury that develops following brain death. In addition, diabetes, which affects approximately 10% of
Ontarians, is a chronic and incurable disease that often underlies chronic cardiac and kidney failure, accounting for the
expenditure of one in seven health care dollars. University Health Network (UHN) has been the site of many exciting
advances in the development of new approaches to repair damaged organs anddevelop stem cell therapies, such as
the creation of insulin-producing cells for diabetes. The Organ Repair and Regeneration Centre (ORRC) proposes to
build upon existing innovative research programs in regenerative medicine, stem cell technologies and organ
transplantation, focusing on the regeneration and repair of damaged organs by establishing the following two
infrastructure suites:

Organ Repair Suite: UHN has developed a world-class research program based on the regeneration of lungs through
the development of the Human Ex-Vivo Lung Perfusion (HELP) system. This system maintains lungs at normal
physiological conditions to restore normal lung function, while preventing damage associated with cold storage.
Furthermore, the HELP system allows researchers the opportunity to maintain and assess the function of donor lungs
prior to transplantation. The successful development of this system has expanded the pool of available donor lungs. To
build on this achievement, the current proposal focuses on the expansion of the lung program towards the development
of innovative organ regeneration systems for the kidney, liver and heart by building a dedicated infrastructure suite—the
Organ Repair Laboratory—that will house specialized ex-vivo perfusion systems for organs.

Organ Regeneration Suite: This suite will build on UHN and the University of Toronto’s cutting-edge stem cell,
regenerative medicine and tissue engineering research towards the clinical application of novel approaches for organ
repair. These protocols will be based on the recent discoveries related to embryonic and induced pluripotent stem cell
technologies. For example, the laboratory will develop cardiac cells and patches to repair damaged hearts and
functional islet cells for the treatment of diabetes. The suite will employ cell culture, expansion and assessment
equipment to enable clinical translation of these approaches.

The development of innovative stem cell-based repair approaches in the Organ Regeneration Suite will be tested not
only in damaged organs but also in organs being repaired by ex-vivo perfusion systems in the Organ Repair Suite. The
successful implementation of the ORRC will expand the pool of donor organs and provide unique approaches to
regenerate damaged organs, both ex vivo and directly within the patient.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University Health Network
Dr. Helen Chan, Research Communications Officer
Phone: (416) 946-2085
E-Mail: hchan@uhnresearch.ca

Lead Researcher(s): Gunther Eysenbach
The mHealth Institute: Creation of an information and communication ecosystem for
web-based and mobile health service delivery
As the population ages, the increased incidence of chronic disease is placing an unprecedented strain on our
healthcare system. Moving certain healthcare services from the hospital to the community and home settingswillhelp
reduce this burden, while improving patient health outcomes. However,effective management of chronic conditions
presents enormous challenges. Foremost, it requires the developmentof new strategies to engage patients and
consumers and new models of care delivery to overcome the shortcomings and barriers of the present system.

Internet-based and mobile health (iHealth and mHealth) applications provide a mechanism to effectively engage
consumers, enhance clinical interventions and improve health outcomes. Despite the rapid shift towards mobile
technologies for healthcare delivery, it has been difficult for researchers to develop, deploy and evaluate innovative
web-based and mobile health technologies in a secure environment that engages patients and connects them to
providers.

This project will build research capacity and infrastructure to design, develop and evaluate the concept, feasibility and
effectiveness of mHealth applications focused on new models of prevention and care for chronic disease self-
management. The ability to formally cultivate amHealth ecosystem of technologies will build on already established
networks, creating partnerships and strengthening infrastructure to create an innovative and leading-edge approach for
the management of chronic disease and health care utilization in Ontario. Thisproject requires the building of the
following infrastructure:

Secure Research Network Platform

The creation of a secure network platform that allows researchers to reach beyond the walls of an acute care facility is
crucial for patient engagement and deployment of innovative mobile technologies. This secure infrastructure will
provide a mechanism for:
• Virtual communities to test technologies and conduct research
• The development of new models of care to engage patients and connect them to providers
• Ensuring security and patient privacy

Centre for Global eHealth Innovation
The eHealthCentre, housed at UHN, was built through a previous CFI investment. Additional funds will build upon the
Centre’s success andfurther update infrastructure and equipment to successfully integrate new mHealth and iHealth
initiatives.

Pediatric mHealth Institute
New research space at The Hospital for Sick Children will expand the capabilities of this Centre as a distinct facility
focusing on the burgeoning area of pediatric mHealth. It will consist of furnished laboratory space in the new Research
and LearningTowerand facilities for interviewing families and children to analyze user needs. The space will include
areas for focus groupsand brainstorming, a design studio, interview rooms and observational areas, with embedded
equipment to allow staff to collect data and study interactions.

Centre for Innovation in Complex Care (CICC)
UHN’s CICC brings together leaders from diverse backgrounds (medicine, nursing, allied health, design, engineering,
research and others) to study healthcare problems todesign, implement and evaluate innovation solutions, including
mobile technology, from bench to bedside. Funds from ORF and CFI would enable the growth of the Centre in this
proposed innovative direction.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University Health Network
Dr. Helen Chan, Research Communications Officer
Phone: (416) 946-2085
E-Mail: hchan@uhnresearch.ca

Lead Researcher(s): John Dick
The Centre for Cancer Epigenomics (CCE): Advancing Personalized Medicine Through
Epigenomics and Genomics
The epigenome has garnered substantial attention in the field of cancer research due to the fact that, unlike the
genome, it can be modulated through both lifestyle changes and pharmaceutical intervention, making it an ideal target
for disease prevention and therapy. The field of epigenomics includes such phenomena as DNA methylation, signals
that tell cells which part of the genome should be silent or expressed; histone modification, alterations to proteins that
bundle DNA into tight packages that can either make it more or less accessible for expression; and the effects of non-
coding RNA molecules, a unique class of molecules that can control the conversion of RNA messages into proteins,
such as short non-coding RNA (microRNA) and long non-coding RNA (lncRNA).

The primary goal of CCE is to understand the role and regulation of the cancer epigenome in order to advance patient
diagnosis and treatment. Recent advances show that the epigenomic state of the human genome is altered in disease,
including cancer, and this can be exploited to advance diagnostics and develop new therapies to impact patient care.
We will conduct fundamental cutting-edge epigenetics research to explore fresh and archival patient tissue toidentify
unique tumour vulnerabilities and therapeutic opportunities. We will integrate existing data on prognostic/predictive
signatures with diverse annotation databases to interpret results and prioritize experiments. To further study cancer at a
systems level, we will examine other genomic/proteomic/non-coding RNA datasets, protein interactions,and
transcriptional networks

This Centre will utilize many state-of-the-art technologies to characterize the epigenome of clinical cancer samples. Key
to the success of this program will be the installation of the latest generation of whole genome, deep sequencers;
advanced validation platforms for multiplexed quantitative detection of gene expression or genome modification; and
computational resources to allow for the processing, storage and distribution of the unprecedented amounts of data
produced by these advanced analysis systems. We plan to use these tools to assess the methylation state of DNA,
specific histone modifications,and non-coding RNA expression.

A major focus of our group is the study of cancer stem cells. Stem cells were first identified at the Ontario Cancer
Institute (OCI) and we have maintained a strong tradition of world-class research in this critical field, with many of the
world’s top stem cell researchers working as part of this research program.While we will not restrict the types of cancers
to be profiled in the case of users and collaborators, our own focus will be directed to the most common solid cancers
(lung, colorectal, breast and prostate) as well as the most common blood-based cancers (leukemia, lymphoma and
myeloma). OCI has strong programs for each of these cancer types and large clinical tissue databases to provide the
critical samples for analysis. Furthermore, these cancers have all been shown to have epigenomic components to their
development and, in many cases (particularly in the case of leukemia), therapeutics targeting the epigenomehave
proven to be beneficial.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Guelph
Dr. Jane Colwell, Manager, Strategic Programs and Infrastructure Grants
Phone: (519) 824-4120 x 58418
E-Mail: jcolwell@uoguelph.ca

Lead Researcher(s): Jim Petrik
Institute for Comparative Cancer Investigation: Facilities for Transformative Cancer
Research
This application is about cancer. We are requesting funds to create research facilities that will synergize with our
existing and growing strengths in cancer research and discovery. At the University of Guelph, we use rodent models of
cancer in our studies, but also use companion and domestic animals which naturally develop cancer and are therefore
excellent models of human disease. The infrastructure will provide us with opportunities for new discoveries about this
disease that are unmatched anywhere. Within our University, we have a unique team of basic cancer scientists, clinical
researchers, and practicing oncologists who will utilize this new infrastructure to discover, develop, and test new cancer
therapies, generate new early detection tools, and strengthen cancer prevention in a “molecules to bedside” approach.
In this proposal, we are requesting funds to support the development of state of the art translational cancer
infrastructure that utilizes the unique expertise, capabilities, and collaborations that we have at the University of
Guelph. With the addition of high-resolution scanning equipment and the development of a tissue bank of naturally
occurring tumours in animals, we will have an unprecedented opportunity to identify, validate, and implement novel
cancer diagnostic, therapeutic, and prevention modalities using an iterative “bench to patient and back to bench”
translational approach.

The focus of this request, translational cancer research, is an area in which Ontario can be a world leader. It is an
opportunity to turn Ontario’s strengths in this field into global leadership. We have established collaborative links with
numerous health related biotechnology companies eager to evaluate their diagnostic and therapeutic agents in animal
models of cancer. Collaborations with our private sector partners will lead to knowledge transfer to the bio- and
pharmaceutical industry. We are also part of the Comparative Oncology Trials Consortium (COTC) of the National
Cancer Institute. This network links industry and 19 North American veterinary schools conducting clinical trials of anti-
cancer therapies on naturally occurring disease in companion animals (dogs and cats). Guelph is the only non-USA
member, which puts us in an excellent position to generate translational discoveries in both companion animal and
human health, in a way that is unique in Canada. Innovative technology for cancer diagnosis and treatment developed
here will improve the return on venture capital for investors. Society as a whole will benefit from the discoveries related
to this infrastructure. Better understanding of the causes and consequences of cancer can lead to improved human
health and well being. Translational cancer research using robust preclinical models for early detection and therapy will
transform our understanding of this disease, leading to improved efficiency in cancer treatment for people, resulting in
savings of both lives and health care dollars.

Over 75,000 Canadians will die of cancer this year and it is now the leading cause of death in Canada. In Ontario
67,000 new cases will be diagnosed, and costs for cancer care in Ontario already exceeds $1.22B. The impacts and
potential benefits of this research are substantial.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Guelph
Dr. Jane Colwell, Manager, Strategic Programs and Infrastructure Grants
Phone: (519) 824-4120 x 58418
E-Mail: jcolwell@uoguelph.ca

Lead Researcher(s): Rickey Yada
Designing food structures for improved life
Consumers are becoming increasingly aware of the connection between diet and health, and are actively seeking out
nutrition-based strategies that have the potential to prevent disease while improving physical and mental/cognitive
health. Capitalising on this increased interest as well as the University of Guelph’s strengths in the agri-food sector,
this project will investigate the linkage between food composition, design, metabolism, function and behaviour. By
understanding the structure-function relationships of food-related bioactives and the importance of the design of food
matrices, the metabolism of these compounds will be optimised and tailored. Identifying bioactive compounds and
enhancing their biological activities using food as a delivery system has the potential to treat and/or prevent various
chronic diseases (e.g., Type II diabetes, cardiovascular disease) as well as to improve immune functions and prevent
bacterial infections. A novel aspect of this project will be the study of the relationships between food composition,
structure, digestion and cognitive function/behaviour.

A team of pre-eminent researchers from far ranging disciplines has been assembled with the capacity to generate data
which will underpin innovative solutions to the food, gut, health, brain and behaviour nexus. The group will focus on five
areas of research:
1. Isolation and characterisation of bioactive compounds/ingredients
2. Assemblies and breakdown of food ingredients
3. Studies of cellular and molecular processes affecting food additive bioavailability
4. Use of animal models to investigate the impact of food bioactives
5. Studies of the human interface examining sensory science, consumer acceptance, and cognitive function

Food ingredient/compound structure, breakdown and interactions that occur during digestion, uptake and metabolism
are challenging topics. Even more challenging is the science required to understand how single molecules/components
ultimately affect physiological and cognitive responses. The approach proposed is novel in examining the relationships
between food and health at the molecular level for which advanced tools are required. Amongst the infrastructure
requested are tools to better understand structure at various length scales, and to identify structural changes,
interactions and products during digestion. Advanced imaging facilities are requested including a scanning electron
microscope, atomic force microscope, super-resolution light microscope, and tools required for remote access to high
throughput cryo-electron microscopy facilities at McMaster University. These will be used to study prepared
supramolecular assemblies and their fate during digestion. Advanced mass spectrometry (matrix-assisted laser
desorption/ionisation (MALDI) time-of-flight (TOF)/TOF), and molecular characterisation tools (Fourier transform
infrared spectroscopy (FTIR), Raman spectroscopy, and isothermal titration calorimetry (ITC)) will be required to
identify compounds such as products of digestion in complex systems.

The relationship between food and health is undeniable and has recently been the focus of much research; however
fundamental mechanistic research is still lacking. In support of the proposed research, the requested infrastructure will
lead to a better understanding of the relationship between food and health using a multidisciplinary approach, the
breadth of which is unique domestically and globally. The research conducted will not only evaluate food based
strategies for efficacy against physical diseases, but will investigate the relationship between food and cognitive health
and behaviour, an emerging area of research.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Guelph
Dr. Jane Colwell, Manager, Strategic Programs and Infrastructure Grants
Phone: (519) 824-4120 x 58418
E-Mail: jcolwell@uoguelph.ca

Lead Researcher(s): Paul Hebert
Digital Biodiversity-Informatics to Applications
This proposal seeks support for two infrastructure modules. The first will develop a DNA-based identification system for
species which occur within Canada, while the second will apply this knowledge for targeted bio-surveillance programs.

Most of our work will be directed toward production of the Canadian Biodiversity Module (CBM), a DNA-based
identification system for species that occur in Canada together with information on their biological attributes and
management status. Most of our work on the CBM will involve capturing information from specimens that are held in
our nation’s major natural history collections, especially those at the Canadian National Collection and the Royal
Ontario Museum. Although these specimens were collected at great cost, their full value has never been realized. We
will gather a DNA barcode record from each of 200,000 specimens representing at least 20,000 different species and
connect the barcode sequence from each specimen with its image and a digital record of all collateral information. The
development of this DNA-based identification system will represent a major advance in our capacity to monitor
biodiversity.

Our application also requests support to construct an Advanced Bio-surveillance Module (ABM) which will make it
possible to take advantage of the remarkable opportunities presented by next generation sequencers to analyze bulk
samples. Their capacity to simultaneously examine many thousands of specimens will have a transformative impact on
the usage of DNA barcoding for ecosystem monitoring. The need for this module arises from the fact that this analytical
approach generates a massive number of sequences which require specialized informatics support to allow their
storage and analysis.

Our overall project will extend the BOLD informatics platform in ways that are critical to better manage biodiversity, an
advance with major economic and policy implications at provincial, national and international levels. It will reinforce the
digital transformation of biodiversity science that was initiated by our earlier awards, providing a ‘green edge’ to both
our governmental agencies and private sector. The need for action is clear – other nations are already developing
regulatory programs based on DNA barcodes that could serve as a barrier to trade in commodities produced by
Ontario. For example, Ontario has the second-largest greenhouse industry in North America, but access to our export
markets could be curbed by the detection of a new pest species. Aside from marketplace applications, DNA barcoding
will help to protect Ontario’s ecosystems from invasive species and it will help to ensure that our agricultural and
forestry activities are protected from pest species.

Our global leadership in this area of science places our province in a strong position to provide analytical services to
other jurisdictions, creating new jobs for Ontario. Although the marketplace for DNA barcode analysis is currently small,
it is growing. For example, the Zoological Museum in Munich will contribute $1.2M to the Canadian Centre for DNA
Barcoding over the next three years to enable the barcode analysis of 70,000 specimens from their collections. These
funds will create employment for two new staff members at BIO. We are determined that this will be the first of many
similar cases where we provide analytical services.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Guelph
Dr. Jane Colwell, Manager, Strategic Programs and Infrastructure Grants
Phone: (519) 824-4120 x 58418
E-Mail: jcolwell@uoguelph.ca

Lead Researcher(s): K. Peter Pauls
Centre for Agricultural Genomics, Metabolomics and Biotechnology
Advances in scientific instrumentation make it possible to assess the molecular and cellular compositions of crop plants
at unprecedented levels of complexity, specificity and throughput. The current proposal is to acquire critical advanced
analytical equipment for researchers in several departments and two colleges at the University of Guelph and at the
Vineland Research and Innovation Centre. The state-of-the-art equipment will allow scientists to conduct internationally
competitive studies in plant molecular genetics, breeding, biochemistry, biotechnology, bioproducts, and
metabolomics by providing the capacity to comprehensively profile the cellular and molecular (ion, DNA, RNA, protein,
metabolite) compositions of large numbers of samples. Guelph is one of the top-10 agricultural universities in the world,
and the top agricultural university in Canada. This equipment is critical to allow high-level plant genetics and
biotechnology-related research to be conducted and will enhance our ability to continue to make new discoveries in
“omics” scale research,

To maintain the leadership in these fields of research, the equipment in the proposal is crucial for identifying genes that
control complex plant traits, analysing crops for novel sets of agronomically-important quantitative trait loci,
constructing plants optimized for bioproduct production and efficiently selecting plants on the basis of their genomes
and metabolomes.

Specifically, the equipment will enable us to:
• genotype large numbers of plants in breeding populations to identify genetic polymorphisms related to disease
resistance, quality, stress tolerance and productivity;
• analyze global RNA expression profiles, the metabolomes of plant tissues and and single cells during development
and environmental challenges; and
• test biocomposite materials, including plant proteins and fibres extracted from crop residues.

The advanced equipment that is being requested will enable our researchers to take leadership positions in providing
biotechnological applications that will shape agriculture in the 21st century and feed the world and includes a: sample
processing robot, next generation DNA sequencer, SNP analyser, flow cytometer, Real Time PCR machine, GCT mass
spectrometer, LTQ-Orbitrap MS instrument, spectrophotometer, Fast Protein Liquid Chromatography system, research
combine and biocomposite analysis equipment.

This infrastructure builds on research and technology development capabilities established through several Leaders
Opportunities or New Opportunities grants to faculty and successes in numerous Institutional Innovation Fund over
$350,000 grants that allowed us to establish an “Agricultural Plant Biotechnology Centre” in the Department of Plant
Agriculture and a Mass Spectrometry Facility in a large inter-college initiative called the “Advanced Analysis Centre”
in the new Science Complex building. The current initiative will also directly enhance the research of four programs
funded by ORF grants including “the Ontario BioCar” Initiative”, “Phaseolus Genomics for Improved Bio-Product
Development”,” Genomics for Agricultural Sustainability” and “Improved Utilization of Co-products from Second
Generation Biofuel Industries for the Production of New Industrial Bioproducts”.

This infrastructure is critical to allow us to attract the very best faculty, post doctoral researchers and graduate
students. The current proposal builds on the previous successes by providing funds to replace well used equipment
and expand our capabilities by purchasing the latest state-of- the-art equipment.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Guelph
Dr. Jane Colwell, Manager, Strategic Programs and Infrastructure Grants
Phone: (519) 824-4120 x 58418
E-Mail: jcolwell@uoguelph.ca

Lead Researcher(s): Claudia Wagner-Riddle, Hafiz Maherall
Predicting and Managing Impacts of Climate Change in Natural and Agricultural
ecosystems of Canada
Every society needs clean water, clean air and secure food supply to thrive. Natural and agro-ecosystems play an
important role in provision of these ecosystem services. However, climate change and intensification of agriculture, as
demanded by population growth, are threatening the ability of ecosystems to provide these services, as well as new
products such as bioenergy. Further, the response of northern ecosystems to climate change is not understood.
Multifaceted interactions can result in unexpected responses to climate change, which can result in positive or negative
feedbacks on climate change. For instance, warmer temperature and altered precipitation patterns will induce
feedbacks in ecosystems that could enhance warming through the release of additional greenhouse gases (GHG), and
deteriorate water quality due to enhanced nutrient loading. Unfortunately, our ability to model these feedbacks is
severely limited by lack of comprehensive ecosystem data under future climate change scenarios. Without such data,
Ontario is presently regulating environmental, agricultural and land-use practices in a vacuum.

To address this knowledge gap, integrated studies of aquatic and terrestrial systems, including managed or agricultural
ecosystems, and holistic approaches that span effects on biodiversity and ecosystem services are needed. We
propose a unique multi-disciplinary approach where ecologists and agricultural scientists will collaborate to develop
mitigation practices based on an improved understanding of ecosystems and feedback mechanisms induced by climate
change. To meet these goals, we request support for infrastructure to study terrestrial (soil, plant) and aquatic systems
at the ecosystem scale. This scale of study is important as it allows manipulation of environmental variables and
management strategies at a realistic scale (i.e. close to field scale), while still providing opportunity to investigate cause-
effect relationships. We will conduct experimental manipulations of environmental conditions (CO2 levels, temperature
and nutrient loading) to evaluate the effect of climate change on the biodiversity of soil microbe, terrestrial plant, and
freshwater microbial and plankton communities. The ability of these modified communities to provide essential
ecosystem services will be measured and best practices to mitigate climate change impacts on Ontario biodiversity will
be identified.

The requested infrastructure is comprised of mesocosm facilities for coordinated ecosystem studies, and instruments
for characterizing biodiversity and ecosystem services in an Ontario context. Existing mesocosms will be enhanced to
enable studies of terrestrial and aquatic ecosystems under winter conditions, yielding crucial knowledge on response of
northern ecosystems to climate change. New field-scale soil mesocosms fully-instrumented for water quality and GHG
emissions will be used to compare processes in natural and agricultural ecosystems. Novel approaches such as
metagenomics, tunable diode laser and cavity ring-down trace gas analyses are proposed to elucidate the fundamental
processes generating clean air and clean water. An integrated approach will be taken to address soil-plant, soil-water,
and soil-plant-water interactions as affected by management practices and climate change.

This infrastructure will benefit Ontario by providing data and models that support the development of environmental
management systems, and improving our ability to predict and mitigate human impacts on ecosystem function,
ensuring the sustainability of food and bioenergy resources into the future.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Guelph
Dr. Jane Colwell, Manager, Strategic Programs and Infrastructure Grants
Phone: (519) 824-4120 x 58418
E-Mail: jcolwell@uoguelph.ca

Lead Researcher(s): Beth Parker
Bedrock Aquifer Field Facility
Water, food and energy are three major resource issues being dealt with in the world today and water is key for the
other two resources. Groundwater represents 96% of the available fresh water on the planet and more than 50% of the
world’s population is dependent on groundwater as their source of drinking water. Fractured rock aquifers represent the
most vulnerable, yet most highly utilized groundwater source in many urban environments, yet they are poorly
understood. Urbanization is affecting the groundwater quality and flow, and influences seepage to rivers and streams.
Contamination from industrial, municipal and agricultural sources is becoming a major limiting factor in expanding and
sustaining water production from the bedrock aquifers in Ontario and globally. Problems will continue to increase with
population and economic growth and needs for agricultural productivity. The greatest immediate risks for adverse
impacts on drinking water, are in those communities drawing their water from aquifers. In Canada, these “groundwater
communities”, like the City of Guelph, serve over 3 million residents. Sustainable supplies of safe drinking water
depend on the assessment of the subsurface contaminant pathways and development of reliable bedrock aquifer
contaminant monitoring systems. Research devoted to fractured aquifers has been minimal; thus there is a great need
for a research facility focused on these aquifers. This proposal enhances and expands the research capacity of the
Bedrock Aquifer Field Facility (the Facility), a unique and vital research centre on the University of Guelph campus.

The Facility is composed of 1) a barn-type building which will house all aspects of the research centre including
laboratory and workshop space, staging for the advanced groundwater technologies, cold rooms, etc., and 2) a high-
density network of boreholes instrumented with state-of-the-science research devices. MRI/CFI funds supported Phase
1 (the structure and drilled subset of research boreholes). The requested CFI funding will be used to complete Phase
Two renovations and installation requirements for field equipment infrastructure, enhanced HQP training and field
sample processing prior to lab analysis. MRI/CFI investment in the facility will enable studies of the Guelph bedrock
aquifer at an unprecedented resolution and scale, such that the City of Guelph aquifer will become one of the most well-
studied, actively used bedrock aquifers in the world. To our knowledge, there is no other facility like this that exists
world-wide. We envision the bedrock aquifer field facility to be the place for researchers from all over the globe to come
and test their new groundwater technologies and ideas. This facility will enhance the training of the next generation of
highly skilled contaminant hydrogeologists, will create new jobs for Ontarians, will enhance existing research programs
and infrastructure at the University of Guelph, and will attract substantial additional research funds over the long term,
solidifying Ontario as a research and innovation leader in this important field.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Guelph
Dr. Jane Colwell, Manager, Strategic Programs and Infrastructure Grants
Phone: (519) 824-4120 x 58418
E-Mail: jcolwell@uoguelph.ca

Lead Researcher(s): Edward McBean
Construction of an Energy Recovery Platform fro Wasterwater
Society recognized many years ago that wastewater must be treated to protect receiving waters, but the capital and
energy costs are substantial, About 20% of the electricity used by a municipality is for wastewater treatment. On the
positive side, we are now recognizing significant opportunities to improve energy recovery from the wastewater. The
dimensions by which we can create these improvements through pilotscale testing include:
(i) by changing the design of anaerobic digesters, we expect to more rapidly generate the biogases and to more
efficiently deliver reject heat to the digesters to facilitate rapid production of the biogas and improve the potential for
electricity generation;
(ii) as urban populations grow, the need exists to expand our wastewater treatment systems. More than forty percent of
the capital costs of wastewater treatment systems are related to sludge digestion. By accelerating the rate of digestion
we capture biogas components and, simultaneously, reduce the necessary ‘footprint’ of the digesters, and achieve cost
savings going forward; and,
(iii) by identifying improved technologies for removal of harmful constituents contained within the biogas, we decrease
parasitic losses (typically around 5 percent) using current technologies (e.g., refrigeration and drying). By identifying
improvements for removal of the harmful constituents, we improve the economics and the efficiency of use of the
energy which is available in the biogas.

There is growing interest throughout the world regarding the potential to decrease energy needs associated with
wastewater treatment. The potential exists for dramatic improvements in both energy efficiency (accomplish more, while
using less energy) and production (move from the wastewater treatment system being a net importer of energy to
exporting energy back to the grid) associated with the wastewater treatment. As well, we can improve pathogen and
emerging contaminant destruction by improving digester design which will make easier, the disposal of digested sludge.

At Guelph, we are extremely well positioned to construct this proposed platform and to establish Ontario as a centre of
expertise. With the ongoing design and construction of the wastewater treatment platform at the City’s wastewater
treatment plant as part of the Southern Ontario Water Consortium (SOWC), we have access to wastewater at a
platform that can be augmented, to expand the research and ‘close the loop’ by investigating energy sector issues.
With the immediate proximity of the SOWC platform, and with the capabilities of the energy platform, we can operate an
energy recovery pilotscale facility and study the performance of alternative technologies to improve the digester
efficiencies, improve the energy recovery efficiencies and remove the harmful contaminants (e.g., siloxanes and sulfur)
that are in the biogas that are causing significant issues with performance of alternative electricity generation facilities.

 Success at identifying innovative technologies and approaches will require a research platform which allows pilotscale
testing. The potential we have to expand the capabilities and operational features via this energy recovery platform will
be unique in Canada and will open up venues to significant opportunities to develop and test innovative and
commercializable technologies for marketing to the world.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Ontario Institute of Technology
Ms. Jennifer Freeman, Manager, Research Services
Phone: 905-721-8668 x3176
E-Mail: jennifer.freeman@uoit.ca

Lead Researcher(s): Ayush Kumar, Julia Green-Johnson
Cellular microbiology laboratory to study microbial pathogenicity and interactions with
human epithelial cells
Multidrug resistance in bacteria was recently identified by the World Health Organization as ‘one of the three greatest
threats to human health’. While in the last few decades there has been an alarmingly rapid increase in multidrug
resistance in bacterial pathogens, paradoxically, our search for novel and effective antibiotics has almost come to a
standstill. This suggests that there is an urgent need to find novel therapeutic options to treat such infections. One such
bacterial species, Acinetobacter baumannii, is a key pathogen that has evolved from being an innocuous bacterium to a
dangerous multidrug resistant organism within the last decade or so. Infections caused by A. baumannii include
pneumonia, bacteremia, and urinary tract infections that are characterized by high mortality rates. A recent study
identified A. baumannii as a major Gram-negative bacterial pathogen in Canadian Intensive Care Units (ICUs) with the
largest number of isolates from Ontario. In spite of A. baumannii’s high resistance and virulence, the underlying
mechanisms remain largely unknown. Importantly, it is also not known if and how multidrug resistance impacts its
virulence. The existing knowledge gaps in the mechanisms of antibiotic resistance and virulence are a major hindrance
in finding effective therapy for A. baumannii infections. In this application, we request state-of-the-art imaging and cell
analysis systems to study mechanisms of antibiotic resistance, virulence, and human host cell interactions of A.
baumannii.

The requested infrastructure will provide us with necessary tools to perform our innovative research, novel opportunities
for expanding collaborative research into antibiotic resistance, and for unique Highly Qualified Personal (HQP) training
opportunities.

1. Fluorescent live cell imaging facility: This facility will greatly assist investigation of A. baumannii virulence factors,
including biofilm formation. Using the confocal microscope, we will study our collection of multidrug resistant A.
baumannii isolates from Canadian hospitals for biofilm formation and thus virulence. This facility will also contain an
epifluorescent microscope allowing us to study the interaction of A. baumannii with key human cell types involved in
infection and host responses. This imaging facility will provide us with novel knowledge about virulence of this
bacterium and its association with antibiotic resistance and pathogenic interactions with human respiratory epithelium.
2. Flow cytometer: This benchtop flow cytometer will allow for precise and rapid quantification of A. baumannii’s effects
on host cell surface molecule expression involved in virulence and host defense mechanisms. This instrument will also
allow us to accurately assess induction of key innate immune parameters induced by different A. baumannii isolates
and phenotypes. The flow cytometry applications will synergize with the live cell imaging work, providing a unique
system for study of A. baumannii–host interactions.

The infrastructure will therefore allow us to carry out highly innovative research providing critical insight into factors
responsible for antibiotic resistance, virulence, and biofilm formation by A. baumannii. The pioneering work proposed in
this application will not only enhance Ontario’s R&D visibility in a global stage but will also be useful for the
pharmaceutical companies in Ontario exploring newer therapy options for antibiotic resistant infections.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Ontario Institute of Technology
Ms. Jennifer Freeman, Manager, Research Services
Phone: 905-721-8668 x3176
E-Mail: jennifer.freeman@uoit.ca

Lead Researcher(s): V.K. Sood
Smart Grid Laboratory (SGL)
Today’s aging and over-stressed electrical grid faces many challenges and must integrate renewable energy sources,
and cope with environmental, power quality and security concerns to morph into the future Smart Grid (SG). This will
only occur due to the convergence of information, communications and power electronics technologies. The proposed
SGL will enable research and technology developments and lead to innovative strategies for the control, protection and
operation of the SG with embedded generation in a rapid, efficient, secure and reliable way.

The SGL is comprised of three simulators and supporting infrastructure. The centre piece is the Real Time Digital
Simulator (RTDS) for modelling the power grid in real-time. This is supported by off-line power system simulation
software (i.e. EMTP-RV and CYMEDIST). Since the SG requires fast, secure communications for operational needs,
the SGL will integrate a Real Time Communications Simulator (EXATA) for modelling communications networks (i.e.
fiber optic, WiMAX, Wi-Fi etc.). This infra-structure has monitoring equipment (from SIEMENS) for power quality
sensing. Since the SGL will generate large amounts of data, fast Servers (from IBM) will be needed for data
processing. The SGL incorporates real-time protection digital relays (from ABB) so that innovative operating strategies
for the SG can be tested. The SGL will use desk-top computers (from DELL) for interfacing to the real-time equipment.
The facility will be completed with small-scale replicas of newly developed equipment for experimental validation in the
future.

The SGL will provide a unique state-of-the-art simulation facility manned by a strong multi-disciplinary and multi-sector
research team enabling research in the Smart Grid (SG) area that is of vital interest to the Ontario economy in the Bio-
energy and Clean Technologies, and Digital Media and Information and Communication Technologies (ICT). Industry
demands for highly qualified personnel (HQP) is growing as aging power engineers retire in large numbers due to
decades of neglect in this sector. The collaborations through this proposal will extend knowledge creation and HQP
training into multiple disciplines i.e. power, communications, controls and protection, software and information, science,
and business. Within the Durham Region of Ontario, the SGL will act as a support and research facility for local
distribution companies (LDCs) i.e. Oshawa PUC, Whitby Hydro and Veridian. There are many other small original
equipment manufacturers (OEMs) i.e. Intellimeter and WireIE, which are partnering together for the Durham Strategic
Energy Alliance (DSEA) led Electric Vehicle (EV) charging stations integration project. These companies lack in-house
research facilities, and look to UOIT for providing much needed HQP and technical leadership.

Furthermore, collaborations with other academic institutions will be encouraged. Dr B. Venkatesh (Director of Centre of
Urban Energy) of Ryerson University, Dr. M. Salama (a leading expert in Distribution systems) from University of
Waterloo and Dr. J. Mahseredjian (a leading expert in simulation of power systems and developer of the EMTP-RV
simulator) of Ecole Polytechnique have all agreed to collaborate. Dr. T. Sidhu (a leading expert in the field of Digital
Protection of Power Systems of University of Western Ontario will be joining UOIT in Jan. 2012.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Ontario Institute of Technology
Ms. Jennifer Freeman, Manager, Research Services
Phone: 905-721-8668 x3176
E-Mail: jennifer.freeman@uoit.ca

Lead Researcher(s): Brad Easton
Energy Materials Characterization Centre (EMC2)
The sustainable production of energy is one of the most critical problems facing our global society. This problem
requires new sources of energy to be both clean and efficient. There are many promising technologies with the
potential to meet these demands. However significant scientific challenges must be overcome before these
technologies can become viable. Common to nearly all these technologies is the need for the development of
advanced materials that lead to improved performance and/or reduced cost such that it is economically feasible for
wide spread adoption of the technologies of solar and hydrogen technologies can become a reality for Ontario.

The 5 applicants have a long-standing collaboration in diverse aspects of materials for energy system, including fuel
cells, hydrogen production, solar cells and nuclear energy. Despite the diversity of fields, these researchers share many
of the same materials characterization needs. Advanced instrumentation is needed to characterize new and emerging
materials. As such, this proposal is for the creation of the Energy Materials Characterization Centre (EMC2) which will
be outfitted with instrumentation that allow for the determination chemical composition and nano-scale properties of
new materials. This information will be invaluable in understanding the relationship between structure and performance
of advanced energy materials leading to the development of higher performing & lower cost energy sources.

The EMC2 will be comprised of the following equipment:
1: Field emission gun – scanning electron microscopy (FEG-SEM) with EDS capabilities
This equipment will enable nanoscale imaging of a wide variety of samples, ranging from new electrocatalysts to
nuclear reactor materials. In addition, the modern EDS detectors will enable rapid determination of chemical
composition. This instrument will be used by all researchers to reveal information about how the structure, composition
and morphology impact performance in the desired energy device.
2: Atomic Force Microscope
A highly versatile scanning probe instrument that allows surface topography to be determined at near atomic resolution.
AFM will be used to determine properties such as surface topographical maps of reactor materials, electrode surfaces,
membrane morphology and catalysts nanostructure.
3: Ellipsometer
Ellipsometry is an indispensable technique capable of determining many materials properties relevant to the research
of all 5 researchers, such as: thin film thickness (single and multilayer), pore volume fraction, depth profile of materials
properties, surface and interfacial roughness.
4: BET Analyzer w/ Micro pore capabilities
This instrument enables the measurement of surface area and pore size/volume distribution, which are key parameters
that impact catalytic activity and efficiency.
5: Atmospheric Sampling Mass Spectrometer (MS) - Upgrade for Thermal Analyzer
This piece of equipment will be added to a Thermogravimetric Analyzer (TGA) unit in Dr. Easton’s lab. The combination
of TGA-MS allows enables evaluation of thermal stability of a materials and quantitatively determination of thermal
decomposition products, which will enable the determination of decomposition mechanisms of new materials.
6: Instrument Technician
A technician will be required to ensure the smooth deployment/operation of all instruments.

Together, this collection of instruments represents an entirely new and unique facility to support the innovative energy
research in Ontario.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Ottawa
Dr. Christian Detellier, Associate Vice-President, Research Office
Phone: (613) 562-5270
E-Mail: Christian.detellier@uottawa.ca

Lead Researcher(s): R. Tom Baker
Sustainable Chemical Synthesis From Renewable Feedstocks
Catalysis plays a ubiquitous role in nearly all chemical manufacturing and important biochemical processes and has
recently been recognized as a primary enabler of clean technology and ‘green’ chemistry. The centrally located,
multidisciplinary Centre for Catalysis Research and Innovation (CCRI) at the University of Ottawa includes 3 managed
facilities and 35 faculty participants from Science, Engineering and Medicine. In addition to its roles in catalysis science
education and collaborative research, the CCRI serves as a resource for government, industry and other university
scientists in Ontario, Canada, and beyond. In this project, unique-in-Canada flow chemistry tools will be used to
combine supported biocatalysts, molecular catalysts and nanostructured heterogeneous catalysts to convert renewable
resources such as wood waste, wheat straw and carbon dioxide into valuable chemicals. The suite for biocatalyst
engineering will enable the generation and screening of large libraries of mutant enzymes and the optimization of their
stability and function, in addition to the high-scale production of lead-engineered enzymes for subsequent catalytic
applications. The platform for high throughput catalyst structure and mechanism characterization serves two critical
roles. It allows for the acquisition of high-resolution structural information on enzymatic and non-enzymatic catalysts in
solution and in their crystalline state, and for screening and discovery of the biological mechanisms of novel
biocatalysts. The requested flow platform will serve as an enabling technology for exploiting the interface between
biocatalysts and nanostructured and transition metal complex catalysts, physically linking multiple modes of catalysis
that would otherwise be incompatible in a single reaction vessel. Finally, lab space renovations to site the
instrumentation and upgrades to some of the existing CCRI equipment are necessary to maintain its world-class stature
and to add essential capabilities in photochemistry and -catalysis. The requested infrastructure will allow the CCRI to
provide Ontario’s chemical industry, other universities, and government labs with an integrated experimental approach
to conversion of renewable feedstocks to value-added chemicals. The CCRI facilities will serve as a resource for
GreenCentre Canada in Kingston, ICFAR at Western, the Bioproducts Centre in Guelph, CRIBE in Thunder Bay and
the Sustainable Chemistry Alliance in Sarnia, enabling process and catalyst optimization for new chemical
manufacturing processes. These groups are allied with all major chemical manufacturers in Canada including Lanxess,
Syngenta, Digital, Greenfield Ethanol, Vive Nano, Toronto Research Chemicals, Dow Canada, DuPont Canada, 3M
Canada, Arkema Canada, BASF Canada, Cabot Canada, etc. Development of efficient tandem catalysis routes to
value-added chemicals from renewable feedstocks will allow these companies to develop new manufacturing
processes that are less dependent on the volatile and long-term unsustainable petroleum market.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Ottawa
Dr. Christian Detellier, Associate Vice-President, Research Office
Phone: (613) 562-5270
E-Mail: Christian.detellier@uottawa.ca

Lead Researcher(s): Robert Boyd, Hanan Ani, Pierre Berini, Steacie Fellow, Ravi
                    Bhardwaj-Vedula, Paul Corkum, Trevor Hall, Karin Hinzer,Jianping
                    Yao, Henry Schriemer, Winnie Ye
Centre for Advanced Potonics: translating discovery to innovation
Nanophotonics, the nexus of nanoscience and photonics, offers ample opportunities for cutting-edge fundamental
research, as well as for transformative technological development. Infrastructure is requested for a Sustainable Access
Network Experimentation Suite; a 3rd Generation Photovoltaic Materials, Devices and Systems Suite; a Nanophotonics
Suite; and a Modeling, Simulation, and Data Analysis Suite to enable research into nanophotonic and nanoplasmonics.
The infrastructure will be housed in a purpose-built Centre for Advanced Photonics that will bring together the photonics
teams to translate discovery in science to innovation in engineering with an applications focus on information and
communications technology (ICT), biomedical sensing, and renewable energy guided by a vision of a ‘sustainable
digital city’ use scenario.

Cities are the dynamo of the global economy and the fountain of innovation. Urban planners envisage a "Digital City" in
which Information and Communications Technology (ICT) infrastructure enables operations to be more efficient and
effective. One imagines an instrumented world that provides ambient intelligence; ubiquitous access to broadband
communication and computing; intelligent energy management that integrates buildings, electric transportation, and
harvesting of renewable energy; and much more.

However, the increased use of ICT is outstripping energy efficiency improvements leading to unsustainable growth in
energy consumption; ICT greenhouse gas emissions are currently doubling every 4 years. It is imperative therefore to
ensure that ICT infrastructure is environmentally sustainable. Whilst there is scope for significant reductions in ICT
energy consumption through incremental research, to achieve sustainability, a breakthrough in component technology
is necessary that nanophotonics has the potential to deliver. In current ICT systems, information is transmitted optically
(fibres) and processed electronically (chips). The interface between optics and electronics and the metal
interconnections on chips have become serious bottlenecks in terms of speed and energy consumption. Nanophotonics
provide prospects for ultra-fast, ultra-small optoelectronic components offering energy consumption that can reach
fundamental limits. Nanoplasmonic devices provide prospects for bridging the size gap between nanometre-scale
electronics and micrometer-scale photonics.

A digital city is also envisaged to be a ‘liveable city’, where the quality of the environment and the health of citizens are
monitored by a multitude of sensors. As with other photonic devices, there are several advantages to shrinking down
optical biosensors and integrating them for use in high throughput lab-on-a-chip applications. Further, laser illuminated
metal tips are used for near-field microscopy, yielding a sub-wavelength resolution in the nanometre range which
promise to provide fundamentally new insight into biological cell function. Finally, new generations of solar cells exploit
nano-engineering promising lower manufacturing costs and enhanced efficiencies.

The research aligns with the focus of ‘Ontario’s Innovation Agenda’ on clean technology and information and
communications technology; to attract the best and brightest talent; and to attract local, national and international
investment. With 85% of the population of Ontario already living in urban areas, Ontario can be in the vanguard to reap
the economic and social benefits of the emergence of digital cities and Ontario enterprises that grasp
commercialisation opportunities generated may reap the benefits of being early to market.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Ottawa
Dr. Christian Detellier, Associate Vice-President, Research Office
Phone: (613) 562-5270
E-Mail: Christian.detellier@uottawa.ca

Lead Researcher(s): B. Jodoin
Advanced Coatings and Bulk Materials Centre: Advanced Powder Production Facility
Major equipment requested

The major infrastructure requested is a Vacuum Inert Gas Atomization facility. It comprises: a vacuum induction melting
furnace in which alloys are melted, refined and degassed; a preheated tundish system; a gas nozzle with which the
melt stream is atomized; an atomization tower and a cyclone. These systems are applicable from laboratory scale up to
large-scale, ensuring commercial scalability of the proposed research/development work.

Research/technology development and benefits to Ontario
State-of-the-art infrastructure will be used to engage in world-leading research and technology development. Three
major programs (see below) will be carried out. They involve the manufacturing of goods (Ontario’s main economical
driving sector) and are directly related to achieving Ontario’s energy conservation objectives and support the objectives
of the Green Energy Act (GEA), intended to boost investment in renewable energy projects and increase conservation,
creating green jobs and economic growth in Ontario.
1. Nanocrystalline (Nc) materials present enhanced strength,and wear and corrosion/oxidation resistance.
Currently, the manufacturing of such materials includes a necessary cryogenic milling step to produce the required Nc
feedstock powder that is then consolidated or sprayed into a protective coating. However, the economics of cryogenic
milling prevent the use of Nc parts or coatings in the industry. Recent developments have shown that it is possible to
produce Nc powders using the requested infrastructure, at a fraction of the cryogenic milling cost; thus, facilitating
future commercialization of newly engineered Nc materials. We aim to produce Nc alloys to manufacture enhanced
aerospace parts, which are currently made using non-environmentally friendly processes. This innovative
technology will position Ontario favourably in the green manufacturing/repair of aerospace parts.
2. Generation IV nuclear reactors are high energy efficiency reactor designs that are expected to be commercially
available by 2030. Goals related to these reactors include improving nuclear safety and minimizing waste and natural
resource use. One important technical issue facing their development is to find/develop suitable materials for their
components. Under reactor operating conditions, most of the structural components suffer severe corrosion or stress
corrosion cracking. As such, newly developed advanced coatings that can be applied to the critical components are
needed. The requested infrastructure will allow the engineering/production of alloyed powder compositions
developed for nuclear reactor application to be sprayed as protective coatings. This technology will position Ontario
favourably in the development of the next generation of nuclear power plants.
3. A large portion of the energy of the fuel burned in heat engines and high temperature municipal waste facilities
escapes with hot exhaust gases. Heat exchangers used to recover this energy must withstand the heat and corrosion
of the combustion gases. We aim to develop a novel technology for manufacturing light weight, low cost, high
efficiency heat exchangers that can withstand high temperatures, for heat recovery. This requires new alloy powders,
capable of withstanding prolonged exposure to high temperatures, that can be deposited by thermal technologies as
skins on new high performance heat exchangers. This technology will position Ontario favourably in the development of
the energy conservation.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Ottawa
Dr. Christian Detellier, Associate Vice-President, Research Office
Phone: (613) 562-5270
E-Mail: Christian.detellier@uottawa.ca

Lead Researcher(s): Michael Rudnicki, Duncan Stewart
The Ontario Regenerative Medicine Cluster
Regenerative medicine is an emerging field of medical therapeutics focused on repairing and replacing damaged cells
and tissues. Ontario is rapidly establishing itself as a leader in this area. This proposal from an internationally respected
group of scientists will build upon a translational pipeline that is successfully developing basic discoveries and bringing
them into the clinic. We have established a multidisciplinary team of basic and clinical scientists that uniquely positions
us to pursue our objectives. The first priority is to accelerate research leading to clinical application of promising
therapeutic approaches for cardiac, muscle, pancreas and brain repair – with an expected impact in the treatment of
cardiac infarcts, degenerative neuromuscular diseases, Type 1 Diabetes, stroke and neurodegenerative disease.
Laboratory and preclinical results with these regenerative therapies have been extremely promising, enabling the
institutions to establish relationships with private sector partners for the purpose of bringing these therapies to the clinic.
We will also utilize the new highly promising induced Pluripotent Stem Cells to further our understanding of patient-
specific mechanisms of vascular disease and to identify drugs to ameliorate vascular disease. Our overarching goal is
that several lead discoveries from the research will lead to clinical trials by the end of the grant period. In fact, clinical
trials are already underway for cardiovascular applications. This project builds on several earlier successful initiatives
that have not only provided new basic research insights but also have had significant clinical impact.

The growing economic and social burden of chronic and degenerative disease resulting from Ontario’s aging population
has accelerated the need to identify new therapeutic approaches. Globally, there is a consensus that stem cells and
regenerative medicine present an opportunity to transform medical practice by offering the potential to cure or alleviate
many of today’s most devastating and costly diseases. The application of regenerative medicine to stimulate tissue
repair has the potential to transform not just clinical practice, but also change the paradigm of health care and the
pharmaceutical industry. The Ontario Regenerative Medicine Cluster will facilitate continued development of Ottawa as
a world-class translational health research centre and ensure Ontario stays at the forefront of the regenerative medicine
healthcare revolution.

The major infrastructure requested consists of: New leading-edge technologies and the modernization/augmentation of
several previously funded systems for the genomics and proteomics core facilities in the OHRI's Sprott Centre for Stem
Cell Research; An equipment suite for the University of Ottawa's Brain and Mind Institute and the University of Toronto
that will support the combination of behavioral analysis, cellular and molecular imaging, in vivo electrophysiology, and
cell biological work necessary for their innovative stroke research program; New flow cytometry and in vivo imaging and
support equipment for the partnered OHRI and St. Michael's Hospital cardiac repair investigations; An Acumen X3
system for CHEO for total cell analysis, that will assist in their pancreatic investigations in conjunction with OHRI; and
Expanded animal housing in the University of Ottawa's Animal Care and Veterinary Services for direct support of all
Ottawa-based programs.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Ottawa
Dr. Christian Detellier, Associate Vice-President, Research Office
Phone: (613) 562-5270
E-Mail: Christian.detellier@uottawa.ca

Lead Researcher(s): Robert Beanlands, Rob deKemp, Mark Schweitzer, Alexander J
                    Dick, Ben J Chow, Frank S Prato, J DaSilva, Kevin Burns, Phil
                    Wells, Marc Ruel, Cheemum Lum
Canadian Cardiac and Vascular Imaging (CanCVIR) Research Centre: Imaging Core of
the University of Ottawa's Cardiovascular Centre of Excellence
There is a pressing need for innovative ways to improve our understanding of cardiovascular disease (CVD) and its
therapeutic strategies. Building on the international success of our imaging facilities at the UOHI, we will develop a
unique research program whose Overarching Theme is the application of innovative advanced imaging technologies:
Positron emission tomography (PET), magnetic resonance imaging (MRI), dual energy computed tomography (CT),
INTEGRATED PET/MRI and other vascular diagnostics, to investigate CVD and its therapies as part of the CanCVIR.

Our Research Objectives are to investigate the molecular and cellular mechanisms underlying CVD and responses to
therapy in the following research areas:
1) dysfunctional myocardium, addressing pathogenesis and regulation;
2) diseases of the vasculature-atherosclerosis and microvascular function;
3) tracking therapeutics with focus on regenerative therapies; and
4) physics and analysis of high spatio-temporal resolution PET-MR using sequential and simultaneous data integration.
New knowledge from each research area will be integrated to better characterize disease and direct therapy.
Advanced imaging technologies are expected to provide a powerful tool for precise anatomical location and functional
imaging of impaired molecular function underlying CVD, ultimately leading to improved patient care.

While there are other PET-MRI initiatives underway in Canada, US and Germany (including an ORF application from
Carleton University pertaining to PET-MRI of Mental Health), the CanCVIR Centre is distinct due to its focus on CVD
and in a unique and innovative development in the field. This application envisions a one-of-a-kind multi-modality
imaging facility designed to accelerate disease understanding and translation to therapies. This complex process
requires a stepwise transition to the ultimate, integrated PET-MRI. The first step requires acquisition of a dedicated
cardiac MRI with multi-modality transport bed (to transfer patients from adjacent modalities without repositioning
between scans). These will be installed in close proximity to new PET-CT creating a Trimodality PET-CT+MRI
complex. During this phase, research will be applied using PET/CT+MRI. The 2nd phase will include purchase of top
of the line dual-energy, Multi-Slice CT (enabling increased image detail, more precise tissue characterization and
quantification, necessary for the development of focused therapies), vascular equipment (for impact assessment of
sympathetic nervous system activity on vascular function), including 3D ultrasound probe for carotid plaque imaging,
and radiochemistry equipment to enable production of probes to be used in the proposed research. In the 3rd phase, a
new integrated PET-MR system will be installed to enable more precise localization of molecular processes with PET
and a polarizer, to be used with MRI to measure cardiac metabolism in real time complimenting different metabolic
measurements with PET.

Ontario is well-positioned to play a major role in the development, implementation, and evaluation of imaging for
cardiovascular diagnostics and therapeutics. Our high calibre team is well established as international leaders in
innovative cardiac and vascular imaging research. Our Program will have a positive impact on Ontario’s
competitiveness through developments in PET/MRI technology and potential therapeutic target identification resulting
from improved understanding of cardiac molecular biology. The state-of-the-art imaging facility will become a unique
international resource for scientists and industry, attracting and retaining the world’s top research talent to Ontario.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Ottawa
Dr. Christian Detellier, Associate Vice-President, Research Office
Phone: (613) 562-5270
E-Mail: Christian.detellier@uottawa.ca

Lead Researcher(s): Laurie H. M. Chan
Collaborative Research for Arctic and Northern Ecosystems (CRANE)
Northern Canada is experiencing significant environmental changes ranging from the melt of glaciers, the production of
new landslides from the thawing of permafrost with the associated disturbance of infrastructure to influences on wildlife
and vegetation. The cutting-edge field and laboratory equipment will enable the measurement and monitoring of ice
melt and thawing permafrost to predict and adapt the northern infrastructure.

We will conduct paleo-studies to provide the appropriate, long-term perspective on how northern ecosystems are
affected by future climate change. The new facility will increase the temporal resolution of our paleoenvironmental data
analysis by an order of magnitude, thereby resolving variability on sub-decadal to century scales which will enable us to
characterize past biodiversity and how it responded to climate variability.

The proposed infrastructure will enable us to define microbial communities of Northern ecosystems and to assess the
impact of environmental perturbations on microbial composition and function. In addition, the contribution of the
gastrointestinal microbiota of Northern population to human health will be studied.

We will also study the effects of chemical pollution caused by the rapid expansion of mining operations across the
North, the extraction of oil sands and the oil and gas development at the Mackenzie Delta and off-shore in the Arctic
Ocean. The new infrastructure will permit estimation of ultralow-level concentrations of metals and organic
contaminants to identify particular effects associated with long-term chronic exposure to low-level contaminant levels.

We will develop comprehensive benefit-risk models for traditional food use in northern communities. With the increased
field capacity, we can use state-of-the-art technology to collect data on nutrition, physiology and ethnology in remote
northern communities and establish associations between determinants of health including food security and
community well-being.

Fundamental to all research conducted is the interaction and engagement among research networks and partners,
northerners, policy makers, and civic groups. Participatory approaches are essential in addressing socio-economic and
health-related issues, enabling two-way exchanges of information, and in facilitating the co-production of knowledge. At
the core of the knowledge translation and communications infrastructure will be a video communications hub operated
in Ottawa that will be linked to six regional centers in the North. The goal of the new infrastructure is to enable effective
knowledge generation and translation of research originating from the interdisciplinary members, groups and networks
involved with CRANE.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Cheryl Arrowsmith
Development of open-access research tools for epigenetics
Research and infrastructure :
The requested infrastructure will support the research activities of the Toronto node of the Structural Genomics
Consortium (SGC), a not-for-profit, international, public-private partnership focusing on the structural and chemical
biology of human proteins, and proteins from pathogenic human parasites. All of the SGC structures, reagents are
publicly available without restriction on use.

To facilitate human health research and drug discovery, the SGC-Toronto will (A) further develop its program in
structural genomics, and (B) expand a novel program in development of “chemical probes” to proteins involved in
epigenetic cellular mechanisms of disease.

(A) Structural Genomics: The SGC will determine 120 new 3D structures within human protein families involved in
cellular signaling systems that are relevant to human disease as well from human parasites such as P. falciparum
which causes malaria. The molecular coordinates of the protein 3D structure are important for the smart design of the
chemical probes described in project (B). In addition, the SGC will develop specialized methods and technologies for
large scale production and purification of the proteins to be crystalized in project (A). These proteins will also be
necessary for the development of the in vitro screening assays used to test the chemical probes. The requested
infrastructure will include replacement and/or upgrades for the key heavily used pieces of equipment required for
protein expression and purification, such as centrifuges, chromatography systems, liquid handling robots and the
NMR.

(B) Epigenetics Chemical Probes: The SGC will also carry out a chemical biology project on proteins that are involved
in epigenetic regulation of gene expression. The ultimate objective is the development of 15 small molecules, or
chemical probes, that can inhibit a specific epigenetic protein and provide information on the protein’s prospects as a
drug target for chronic diseases such as cancer, inflammation, and neuropsychiatric disorders. The SGC will first
develop biochemical assays to screen large collections of chemical compounds provided by our academic collaborators
and industry partners for activity on the epigenetic proteins. The 3D structure of promising compounds will be
determined while bound to the protein, and their chemical structure modified to improve potency and selectivity. To test
for the compounds activity in an intact human cell, different cellular-based assays will also be developed. The optimized
“chemical probes” will then be placed in the public domain to allow the wider biomedical community to research the link
between the protein’s activity and different diseases. The infrastructure requested to develop and perform medium
throughput screening of small molecule libraries include 384-well format scintillation counter, liquid handling robots,
plate readers, surface plasmon resonance instrument and an upgrade of our NMR spectrometer magnet console to one
that can efficiently perform fragment-based chemical screens.

Benefits to Ontario:
1. Development of local research talent and training of HQPs
2. Enhance Ontario’s profile in the global scientific community
3. Stronger collaborations between researchers in Ontario and the global community
4. Potential economic benefits through (i) commercialization of the research tools, (ii) job creation, and (iii) development
of new medicines for important diseases.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Jörg Bollmann
A Field Emission Electron Microprobe for Exploring Environmental Change Through
Time
Over the past decade, a research strength has emerged at the U of T that explores the response of the biological world
to large-scale changes in Earth’s surface environment. The work addresses some of the most important scientific
questions engaging society by developing and interpreting the long-term record of past surface conditions; such
information serves as the essential baseline for predicting the amplitude and frequency of future global environmental
change and the effects of human-related activities. This research has an influence on public policy at the national and
international levels, in terms of formulating a societal response to climate change, finding strategies for climate-change
mitigation, and monitoring the nature and scale of anthropogenic pollution. This is an interdisciplinary research effort
involved in the discovery of high resolution chemical and isotopic proxies for the past temperature and composition of
the oceans, detailed records of the biotic response to climate change, and methods to trace the human-induced impact
on global geochemical cycles. CFI/OFR-supported infrastructure has been essential to the success of this work, with
~$6 million invested in U of T laboratories involved in high resolution mass spectrometry, detailed textural and chemical
analysis of biomineralization and the stratigraphic paleoecology record. An important outcome of this work is the
recognition that a major portion of the paleo-environment and geochemical cycling record has yet to be accessed. This
shortcoming is owing to limitations on the spatial resolution and sensitivity of available methods for in situ chemical
analyses of the bio-mineralized materials (e.g., foraminifera, calcareous dinoflagellates, diatoms, coccoliths, and
ostracodes), inorganic precipitates (e.g., seawater barite), and anthroprogenic carrier phases used to construct these
records. If quantitative chemical analyses of these phases could be done, then U of T researchers could significantly
expand the paleo-environment record to as yet unexplored environments, use new environment proxies, and achieve
fresh insight into the isotopic signals of global chemical cycles. The essential infrastructure required to facilitate this
transformative research employs a new application of field emission electron guns used in a microanalysis
environment, or so-called Field Emission Electron Microprobe (FE-EMP). The FE-EMP provides nanometer-scale
spatial resolution, allowing for non-destructive chemical analyses to be performed on the ultrasmall mineral domains
which characterize many of the phases precipitated in the low temperature surface environment. Combined with
wavelength-dispersive elemental analysis allows elements from Be to U to be measured with sensitivity of less than
100 ppm. As chemical analysis at the nanoscale is an emerging technique for materials produced in the surface
environment, HQP with very diverse research interests will be exposed to a unique training experience. Whereas the
existing CFI-funded laboratory facilities can separately provide isotopic analyses, high resolution imaging and detailed
paleo-ecological constraints, the proposed infrastructure would provide an innovative and effective link between the
chemical and textural records, unique worldwide. As such, the FE-EMP would be a focal point for high resolution
temporal studies of past environmental conditions and coalesce the existing research programs into the establishment
of a globally-leading facility for studies of Earth’s surface environment.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Eyal de Lara
Experimental Next Generation Cloud Computing Lab
Cloud computing is transforming the information technology landscape by shifting the hardware and staffing costs of
managing computational infrastructure to third parties, such as Amazon or Canadian Cloud. The pay-per-use model of
cloud computing makes it possible for organizations and individuals to deploy global-scale services or execute high
performance jobs, while only paying for the marginal cost of the actual resources used.

Unfortunately, existing clouds fall short of the performance, reliability, and security required by a broad range of
applications. In addition, current cloud datacenters make inefficient use of electricity and cooling resulting in a sizable
and growing environmental footprint. The proposed infrastructure will make possible world-class research into next
generation cloud computing technology that will expand the range of applications and services that can make effective
use of cloud computing, while reducing the environmental impact of cloud datacenters. The infrastructure will support
research that: (i) enables the efficient execution of data-intensive high performance applications, (ii) reduces the effort
required to deploy commercial applications that resize their resource allocation to track variations in load, (iii) lowers the
environmental impact of cloud datacenters by developing more efficient cooling strategies, (iv) leverages
heterogeneous hardware to speedup application execution and reduce energy consumption, and (v) improves cloud
security.

Ontario’s strength as a source of cloud computing technology is widely recognized. For example, Toronto-based Novell-
Platespin and Platform Computing are world leaders in the development of cloud management software. Ontario also
has a growing number of startup companies that develop cloud technology, such as GridCentric, Tucows, and
Synaptop. The proposed lab will make possible transformative research that will enhance Ontario’s leadership position
in this field, providing Ontarian companies innovative technology that gives them vital competitive advantages.

The infrastructure will support research on a broad range of subdisciplines in the area of computer systems that are
fundamental to cloud computing including virtualization, networks, operating systems, database systems, file systems
and storage, performance tuning/monitoring, fault tolerance, and web services. The PIs have conducted award-winning
research in these areas, and have a proven track record of successful industry collaboration and technology transfer. In
addition, the infrastructure will make it possible to train the next generation of highly qualified personnel that are in
urgent demand to support the continued success and rapid growth of the Ontario cloud computing industry.

The proposed infrastructure has four main components: (i) customizable compute nodes with specialized hardware
components such as FPGAs, GPUs, and ARM-based processors, (ii) a customizable network testbed of
reprogrammable hardware and software components, (iii) a storage and sensing infrastructure to measure power and
heat, and (iv) space renovation to refit a machine room to house the infrastructure.

The proposed lab will make possible research that cannot be pursued on production clusters, such as SciNet, due to
the requirement for access to the privileged levels of the hardware and software stack, namely: modifications to
topology, hardware, and operating system; exploration of specialized hardware support; deep analysis using custom
sensors and instrumentation; and widespread failure injection.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Ömer L. Gülder
High pressure blow-down facility for gas turbine combustion research
The requested infrastructure will provide the means to advance combustion science and facilitate the development of
technologies that can revolutionize the future design of gas turbines. The anticipated advancement of gas turbine
technology will directly benefit aircraft propulsion systems as well as industrial energy production.

Combustion science and technology remain one of the most challenging technological fields. These challenges
become even more formidable at the elevated pressures at which gas turbines operate. Future gas turbine combustors
will be operating at even higher pressures, approaching 4 MPa (600 psi), so as to maintain and improve system
efficiency while reducing pollutants. Combustion phenomena at these high pressures are highly coupled, and many
fundamental questions currently exist with respect to phenomenologically correct characterization of various
combustion processes.

The current proposal will enable improved understanding and control of high-pressure combustion, which is crucial for
the design of next generation gas turbines and other high-pressure combustion devices. There is currently no
satisfactory design approach other than trial and error, and there is a fundamental lack of experimental data and
complementary predictive models. The proposed high-pressure and high-temperature blow-down tunnel combustion
research facility will address these deficiencies by enabling high-fidelity diagnostic experiments, which will be
accompanied by high-fidelity simulations.

This state-of-the-art infrastructure is required at both the Canadian and the international levels to advance our
understanding of high-pressure combustion, pursue transformative research and attain international leadership. The
proposed facility will provide a unique opportunity to create a strong and vibrant research environment that will attract
excellent young researchers. The resulting knowledge and technologies will improve the quality of life through reduced
pollutant emissions and fuel consumption, and will enhance the global competitiveness of Canadian gas turbine
industries.

The key challenges of engine R&D include emission reduction, improved fuel efficiency, noise reduction, materials, and
design optimization. The multifaceted aspects of the proposed research program will provide a unique educational
experience for the engineers, scientists, technologists, and students involved in projects utilizing the new combustion
research facility. Our current collaboration with the National Research Council Canada (NRC) and Pratt and Whitney
Canada (P&WC) will lead to new opportunities for interactions, including exchanges of researchers and engineers from
our respective organizations. Joint experiments and shared facilities will broaden the learning experience of the
students and other research personnel.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): David S. Guttman
Translational Genomics of Plant & Microbial Diversity
Genetic diversity, whether segregating in natural populations, agricultural cultivars, or mutagenesis lines, is the
foundation of adaptation and innovation. Recent breakthroughs in biological sciences, information theory and analytical
instrumentation have revolutionized our ability to collect, analyze and apply genetic information, and thereby harness
the incredibly rich information patterned in the genetic variation segregating among populations. For example, instead
of simply asking what genes are encoded in a species genome (with the underlying simplifying assumption that all
members of a species are genetically homogeneous), we can now ask questions about the association between
genetic variants and an individual’s fitness (e.g. predisposition to a specific diseases). Genetic variation is the currency
of evolution, and underlies susceptibility and resistance to disease, the expression and transmission of deleterious or
beneficial traits, and the very foundation of our perception of self, family and community. Major efforts are currently
underway to harness the incredibly rich information encoded in our gene pool. Examples include personalized
genomics, which uses an individual’s genomic information to tailor preventative measures and treatments, and marker
assisted breading, which uses genome information to more effectively select for or against specific traits in plant and
animal breeding.

This proposal supports state-of-the-art research platforms that will allow us to systematically mine this rich resource and
identify genetic variants underlying new traits with untapped potential for translating the fundamental to the applied. The
goal of our group is to find these variants to answer a variety of basic and applied questions in plant and microbiological
research.

This proposal builds upon a 2007 CFI/ORF proposal, Centre for Plant Phenogenomics, which provided funds to
purchase genomic equipment, which has been managed by the Centre for the Analysis of Genome Evolution &
Function (CAGEF). CAGEF’s mission is to promote research and education in genome biology. It is the technical core
for numerous research projects focused on translational genomics for sustainable agriculture and microbiome analysis
for healthy plants and people. CAGEF-supported research goals include:
• Identify genes that enhance resistance to plant pathogens, modulate response to drought, temperature, nutrient and
light stress, and change plant cell wall structure.
• Develop reference genome sequences to support the development of bioenergy crops.
• Study adaptation among agricultural cultivars and natural populations to identify the genetic basis of adaptive traits
and promote their translation into agronomically viable bioproducts.
• Characterize the dynamics of microbial communities to promote sustainable agriculture, study pathogen persistence,
and track epidemic strains.

This proposal is focused on supporting these research programs by sustaining and upgrading CAGEF’s critical
resources purchased through prior CFI/ORF support. Specifically, we request support to:
• Upgrade our genome sequencers.
• Purchase service contracts to ensure the continued support of CFI/ORF-funded research platforms.

Funding of this proposal is absolutely essential to ensure the continued viability of the previously purchased CFI/ ORF
platforms, the research and education programs of CAGEF, and the numerous associated research programs aimed at
translating fundamental plant and microbiological research into economically and environmentally sustainable
bioproducts and resources.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Murray Krahn
Center for the Evaluation of Technological Innovation (CETI)
The most fundamental challenge facing the Canadian health care system in the next few decades is sustainability.
Canada faces slow growth and ongoing deficits in the face of increasing health care costs. Technology clearly drives
health care costs upward, accounting for 50% of the growth in health care costs over the past 50 years. But innovations
also save lives, as well as driving growth and employment.

Health Technology Assessment (HTA) draws from evidence based medicine, health economics, and bioethics. Its
traditional role has been controlling inappropriate diffusion of health technology and constraining costs. The private
sector, however, considers HTA to be just another barrier to innovation.

Building on the success of existing collaborations, the Centre for the Evaluation of Technological Innovation (CETI) will
draw together the very substantial resources at the U of T to become a leading international HTA methods and policy
center. We will break new ground by addressing the challenges of both innovation and sustainability together. We will
work with government and industry to bring the process of HTA upstream, much earlier in the technology development
process. This is potentially transformative- new product decisions can be made much earlier in the technology
development cycle. We will also expand current innovative efforts in use of administrative data, large-scale policy
models, and field trials. This new partnership will establish Ontario as a premier location for technology development.
i) Optimal use of infrastructure- CETI will draw together existing staff including more than 25 investigators, 20 staff, and
more than 20 PhD students. We expect the number of scientists and students to grow quickly. The centre will provide
methods support, space, and infrastructure to a wide array of investigators and trainees.
ii) Promotes networking, collaboration and partnership- Our existing network includes the Faculties of Pharmacy and
Medicine, Cancer Care Ontario, and the University Health Network. We work closely with the provincial government,
and collaborate with investigators in Canada, the US, Europe, and China. Our multidisciplinary research includes health
services and clinical research, health economics and bioethics research relevant to HTA. CETI will expand this to
include new industrial and government partners.
iii) Stimulates the training of highly qualified personnel- CETI will build on existing efforts. The Toronto Health
Economics and Technology Assessment (THETA) investigators train many PhD and MSc students through Pharmacy
and IHPME. THETA offers research internships and fellowships, teaches an annual summer institute on HTA for
decision makers, and plays a vital role in the CIHR Health Care Technology and Place strategic training program.
Nearly all of current employees either possess a PhD or are currently in a PhD program.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Alberto Leon-Garcia
Future Internet and Applications Testbed
The Future Internet and Applications (FIA) testbed will provide a distributed facility for experimental research on novel
applications and smart infrastructures, extended cloud computing and Future Internet protocols. The testbed will consist
of a flexible, programmable, virtualized converged computing and communications infrastructure that gives Ontario
researchers dedicated high-performance network and processing resources to experiment with new paradigms for
cloud computing, new ICT infrastructures to enable smart transportation and smart grids, and novel Future Internet
protocol stacks that are secure, reliable, and scalable. The FIA testbed design includes virtualized programmable
hardware that allows researchers to test protocols at scale, in realistic scenarios, thus minimizing the time to
implementation and commercial deployment. The testbed will consist of a network of Smart Edge clusters and Core
datacenters interconnected by CANARIE and ORION.

The FIA testbed will also provide a platform to support experimentation in applications built on advanced services that
anticipate future very-high bandwidth wireless access networks. The FIA platform will offer frameworks for creating
large-scale data-intensive applications, user-centric applications on smart mobile devices, and real-time collaborative
virtual reality applications. The FIA testbed will nurture an ecosystem for open source projects and it will offer
developers tools for building applications by composition and mashup of the above frameworks. These applications will
be deployed in an operational part of the testbed and the academic community will be invited to opt-in as users. This
approach accelerates the rate at which applications can be deployed to full scale.

The design of the FIA testbed is supported by research from the NSERC Strategic Network for Smart Applications on
Virtual Infrastructures (SAVI). SAVI is a collaboration of 9 Canadian universities and 20 industry, research and
education networks, and high-performance computing centres with the goal to design future application platforms built
on flexible, versatile and evolvable infrastructure that can readily deploy, maintain, and retire the large-scale, possibly
short-lived, distributed applications that will be typical in the future application marketplace. Another major use of the
FIA testbed will be to support at-scale experimentation by an ORF Research Excellence project that is designing a data
management platform for gathering street and highway traffic state information and distributing it in real-time to private
and public transportation application providers.

The FIA testbed and its partner research projects help advance Ontario’s Innovation Agenda by strengthening the
industrial base in information and communications technology (ICT) through the active participation of its partners in the
research program and in the preparation of highly qualified manpower with expertise in the design and operation of
globally competitive ICT infrastructure and the creation of innovative and disruptive products, services, and
applications. The SAVI Network supports 50 graduate students per year working on longer-term research issues as
well as shorter-term industry-partner defined projects. This approach bridges the gap between the time horizons of the
universities and the companies, and it speeds up the transfer technology and know-how, helps identify new product and
service opportunities, and prepares students for working in industry.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Charles A. Mims, Doug D. Perovic, Paul Santerre, Geoff A. Ozin,
                    Roger Newman, Steven Scott, Uwe Erb, Yu Sun, Zheng-Hong Lu,
                    Christopher Yip
Ontario Centre for Characterisation of Advanced Materials
The Ontario Centre for Characterization of Advanced Materials (OCCAM) will be created with this proposal by enlarging
an existing centre for the study of the surfaces of materials. Ontario has a powerful concentration of advanced research
and development activities that are trying to create and use new materials for a wide variety of uses. These programs
are trying to create biomaterials for use in surgery and tissue repair and “nano-scale” (on billionth of a meter) materials
which have very special properties for use in solar energy, energy storage, electronics and communications. Others are
investigating catalysts for renewable energy technology and new metals that resist corrosion. Still others are studying
the aerosol particles in the air and their health effects while others are studying rocks under the ocean to understand
where we might find new geological resources. All of these researchers need to study their materials, how they are
structured at the atomic level both at their surfaces and in the bulk. Surface structure and reactivity is important for
many of the applications: it is the surface of biomaterials that interact with the human body and it is surface chemistry
that governs whether paint will stick to something or whether it will rust or corrode. The bulk chemical structure governs
other properties (electronic properties for and the strength of alloys). The surface and bulk structures of materials are
connected and together they can influence how well a material performs.

It is easy to see that all of these programs have great possibilities to make our lives healthier and more productive. It is
also easy to see that all of these programs need the best information that can be obtained about the structures of their
materials in order to compete with the best in the world and move these important research areas forward. The tools for
obtaining this information are more expensive and specialized than the individual researchers can support. This creates
a need for central facilities that are maintained by specialists where the researchers can flock. This proposal will
expand an established and productive centre, complementary to other Ontario facilities, for the study of surfaces and
interfaces (Surface Interface Ontario – www.si-ontario.utoronto.ca) to include newly available techniques for the study
of surfaces and bulk properties. These new capabilities will include electron microscopes capable of operating at a
controlled sample temperature and gas environment. It will also include scanning probe techniques capable of
resolving structures at the nanometre level. This centre, staffed with research scientists and offering
advanced/specialized sample handling/preparation capabilities is already a leader in the analysis of difficult materials.
The enhanced facility will offer world-class “one stop shopping” for Ontario’s leaders in materials research and
development.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Dae-Sik Moon
Technology and Instrument Developments for Space and Ground-Based Astronomy
We propose to develop the next generation of astronomical spectrographs for observations in the optical and near-
infrared wavebands based on the newly emergent technologies of “polarization gratings” and micro-slit arrays (MSAs).
These technologies can significantly improve the sensitivity and efficiency of astronomical spectrographs. New
spectrographs, based on the new technologies, will be used to explore some of the most fundamental questions in
astrophysics, such as extra-solar planets and the origin of the universe, in unprecedented ways.

Astronomy, by its nature, is a science of phenomenology, interpreting the cause of the observed phenomena, which is
ever dependent on the powers of observational instruments and facilities. As such, most of groundbreaking new
discoveries in astronomy result from new observational facilities or experiments based on cutting-edge technologies
developed in relevant engineering fields. (In fact, sometimes it is astronomical requirements that drive fundamental
technology development, e.g., CCD sensors and WiFi.) Recent developments in the fields of telecommunications and
optical engineering now make it possible to develop highly efficient, achromatic “polarization” gratings, which are based
on the vector wave nature of light. Also rapid developments in the field of micro-electro-mechanical systems have
brought the advent of addressable MSAs with large number of shutters suitable for astronomical applications. These
technologies can be used to overcome the two critical limits of conventional spectroscopy: 1) the low efficiency of ruled
gratings; 2) the lack of multi-object spectroscopic capability in the near-infrared wavebands. We will conduct very
sensitive and efficient spectroscopic observations using new spectrographs based on the developed technologies that
are designed to maximize the potential for important scientific discoveries.

The proposed technology will be developed through strong domestic and international collaborations with research
institutions and commercial companies. For the polarization gratings, after the initial design work by researchers and
students at the University of Toronto (UofT), we plan to fabricate them in partnership with Canadian photonics
companies. For the MSAs, we are collaborating with the scientists at NASA/Goddard for their characterizations and
future improvements. The construction of astronomical spectrographs based on the developed technologies and final
telescopic observations with these instruments will be conducted in collaborations with other universities and
institutions in Canada and the US. The major equipment to be purchased in this project includes the polarization
gratings, opto-mechanical components of the spectrographs, and detector and electronics.

The proposed research will benefit Ontario in various ways. The development of the proposed technologies/instruments
will certainly elevate Ontario’s manufacturing capabilities in the fields of optical fabrication, telecommunication, nano-
fabrication, space technologies, etc. Success of the proposed development plan will place Ontario as one of the world’s
leading places in the field of experimental astrophysics and astronomical instrumentation. This will certainly create
opportunities for Ontario to participate in the present and future construction projects of large-scale astronomical
observational facilities such as the Thirty Meter Telescope of which total construction cost is greater than 1 billion
dollars. It will also attract many young, talented researchers and students from across Canada and abroad, providing
unique opportunities for training highly qualified personnel.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Dana Philpott
The Host-Microbiome Research Network
Description:
Our intestines contain a complex universe of microorganisms that out-number our own human cells by a factor of ten.
These commensal microorganisms can significantly affect diverse health outcomes, including cancer, obesity and
autoimmune disease. Strikingly, little is known about what constitutes a “healthy” microbiota and how microbes might
promote health or disease. The overall goal of this application is to create a network of basic and clinical scientists that
will investigate the impact of commensal microorganisms in animals models of human disease with the aim to identify
how these microorganisms either promote or prevent disease. With our clinical partners, we can perform primary
investigations into the characterization of the microbiome in different human diseases and translate our basic findings
into meaningful recommendations for preventative and therapeutic strategies based on pre- and pro-biotic intervention.
The Host-Microbiome Research Network will integrate three inter-related state-of-the-art centres, focusing on
manipulation of host-microbiota interactions using mouse models and humanized mouse models (ie mice with human
stem-cells) of human disease, visualization of host-microbiota interactions using high-resolution microscopy and
analytical equipment and, finally, studying these events in humans will aid in translation of host-microbiota
technology/biology to human disease.

Major Equipment:
Microbiota manipulation: In order to assess the contribution of the microbiota to a certain disease, the gold standard in
the field is to render mice germ-free (GF) and either maintain them in this state to determine how microbes in general
affect disease outcome or give mice a defined microbiota to ask how specific microbes contribute to disease. This
approach necessitates the implementation of GF isolation units for animals as well as specialized handling and
processing equipment to maintain GF status. Microbiota visualization: We plan to acquire state-of-the-art imaging and
analysis equipment that will sample cells directly from the lining of the intestine and ask how specific microbes interact
with these cells at the molecular level. We will also acquire microscopes with intra-vital technology to assess in real-
time the cross-talk between microbes and host cells. Microbiota translation. We will determine how the microbiota
influences human disease, and in particular gastrointestinal diseases like inflammatory bowel disease and colon
cancer. These investigations will require cataloguing and bio-sampling patients, microbiota analyses and correlation
with disease severity and response to therapy. A magnetic resonance imager, specifically dedicated to intestinal
inflammation and cancer research, will be requested in order to address these questions.

Benefit for Ontario:
The creation of the Host-Microbiome Research Network will benefit Ontarians, both in terms of improved health care
and economic growth. In terms of health care, The Network will increase our understanding of the relationships
between the microbiota and the development of chronic disease and, ultimately, will help to
(a) shape meaningful change in health policy (i.e. nutritional guidelines based on our research);
(b) enable early disease detection and prediction; and
(c) identify interventions that prevent, slow the progression, or reduce the severity of chronic diseases.

As for economic benefit, biological and technological breakthroughs stemming from the implementation of this
infrastructure has potential in terms of commercialization. Moreover, the development of new technology will foster the
recruitment of new individuals to this field and contribute to the training of highly qualified personnel.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Milos R. Popovic
Centre for Research in Advanced Neural Implant Applications – CRANIA
In Canada, more than $105 billion are spent annually to treat diseases and injuries of the brain. Such disorders include
epilepsy, depression, Alzheimer’s disease, Parkinson’s disease, stroke and spinal cord injury, and will affect one in four
people at some point during their lifetime. The purpose of the Centre for Research in Advanced Neural Implant
Applications (CRANIA) is to create facilities that will enable a multidisciplinary team to develop advanced implantable
devices for the treatment of neurological disorders. The CRANIA project is designed to capitalize on the Toronto area’s
world-leading expertise in neurosurgery, neurology, neuroscience and biomedical engineering, in order to create a
team that will be unique in the world in its ability to develop, manufacture and provide clinical support for next-
generation neural implants.

The unique CRANIA infrastructure will consist of:
a) clinical, research and design facilities where neural implants will be designed, assembled, tested, sterilized,
customized for individual patients and maintained across a patient’s life span (University of Toronto, Toronto Rehab
and Toronto Western Hospital); and
b) clean room facilities where components of the neural implants will be manufactured (University of Toronto).

These will allow us to develop:
1) implantable diagnostic systems for patients with Parkinson’s disease, epilepsy, dystonia and essential tremor that
will monitor patients’ neuronal activity continuously for days and weeks while the patient performs activities of everyday
life. These monitoring devices will be wirelessly connected to external sensor systems to help identify which events
trigger unwanted behaviors such as seizures.
2) a new generation of deep brain stimulators (DBS) that will minimize or eradicate motor symptoms caused by
Parkinson’s disease by selecting, in real-time: i) the brain sites to target for stimulation using an array of implanted
electrodes, and ii) the most appropriate stimulation patterns.
3) brain-machine interfaces (BMI) that will determine patients’ intentions in real-time and use that information to control
neuroprosthetic or other assistive devices.

CRANIA will serve as the catalyst for a new segment in Ontario’s medical device industry. Technology developed
through CRANIA efforts will be commercialized through the use of Ontario start-up companies (including Functional
Neuromodulation, Neurochip and Simple Systems) as well as through existing industrial partnerships with market
leaders (including Medtronic, Boston Scientific, St. Jude Medical, Fatronik, Neurostream Technologies). CRANIA-led
research is expected to markedly improve the treatment of neurological disorders in Ontario and across the world,
improving the quality of life of patients and easing the economic impact on the health care system.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Gregory Scholes
Solar energy circuits
Solar fuel production often starts with the energy from light being absorbed by an assembly of molecules that transmit it
to a reactive site that uses the energy to power chemical processes. For example, in photosynthesis, antenna
complexes capture sunlight and direct the energy to special proteins called reaction centers that then, powered by this
energy, carry out biochemistry. A key challenge is that the energy from sunlight, once captured by a molecule, is only
stored for a billionth of a second. This leaves little time to route the energy from pigments to molecular machinery that
produces fuel or electricity, or performs another function like a sensor. In a recent review published in Nature
Chemistry, Scholes and co-workers described the principles learned from studies of various natural antenna complexes
and suggested how to elucidate strategies for designing light-harvesting systems. We forecast the need to develop
ways to direct and regulate excitation energy flow using molecular organizations that facilitate engineering principles
such as feedback and control. These and other insights inspired by the natural world promise to revolutionize our ability
to harness the power of the sun. The requested infrastruture will enable us to study both natural systems as well as
specially designed assemblies of molecules to determine how these solar energy ‘circuits’ operate—and hence how we
can design new circuits and materials for capturing and using energy from light.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Sachdev Sidhu
The Toronto Recombinant Antibody Centre
Human antibodies have emerged as major therapeutic agents for the treatment of cancer and other devastating
diseases, and the market for antibody therapeutics currently stands at more than $30B annually. Our major goal is to
establish a program for efficient development and large-scale production of synthetic antibodies, which will be achieved
through the Toronto Recombinant Antibody Centre (TRAC) at the Donnelly Centre for Cellular and Biomolecular
Research (DCCBR). The TRAC is based on state-of-the-art synthetic antibody technologies developed by DCCBR
investigators, which can be applied to the generation of candidate therapeutic antibodies against a wide variety of
antigens in a high-throughput pipeline. Our ultimate aim is to produce highly valuable resources for drug discovery with
substantial commercial opportunities through development of a panel of diagnostic and candidate therapeutic
antibodies suitable for clinical testing in patients. Toward achieving this goal, we have assembled a consortium of
leading cancer biologists and drug discovery experts from the Canadian research community, and together, we have
compiled a panel of cancer-related surface proteins representing high-value targets for developing next-generation
targeted cancer therapeutics. The TRAC represents a unique and complete program for the development of antibody
therapeutics in a Canadian academic environment. Antibodies emerging from this program will be powerful tools for
discovery research and we anticipate a significant subset will be candidates for new therapeutic entities. In sum, the
TRAC program will have a major impact on basic research, on therapeutic options for treatment of multiple human
diseases including cancer, inflammatory and immune diseases, and on the development of commercial biotechnology
in Canada.

We are requesting funds to acquire infrastructure (customized robotics and liquid handlers for phage display selections,
a next generation sequencer, flow cytometer, high content imaging instrument, shaker/incubator system and large-
scale FPLC for protein purification and computer servers for data storage) to establish an automated pipeline for
discovery and development of novel candidate antibody therapeutics. The TRAC pipeline is based on three fully
integrated platforms designed to develop and produce high quality antibodies, allow for systematic validation of
antibody leads and rapid translation of these antibodies into therapeutic candidates.
1) Antibody development platform: The automated systems will support high-throughput generation of synthetic
antibodies against an extensive panel of secreted and surface proteins associated with cancer and immune diseases.
These systems are based on well-established phage-display methodology using purified recombinant antigens as well
as a new innovative methodology, termed ‘CellectSeq’, which enables selection and identification of antibodies against
antigens displayed on mammalian cell lines.
2) Antibody validation and characterization platform: This platform enables rapid identification of antibody leads with
desirable biophysical and functional properties to ultimately uncover their potential research and therapeutic utilities.
3) Antibody production platform: A highly efficient platform enabling production of antibodies generated in Platform 1
and validation of their binding and functional properties in Platform 2. Based on our established methodologies, this
platform will enable antibody expression and production directly from bacteria as well as production of full-length,
bivalent antibodies (the preferred format for antibody therapeutics) in mammalian cells. More importantly, this capability
will also enable production of high quality antibodies in quantities sufficient for in vivo efficacy and safety studies in
rodents enabling a better understanding their therapeutic potential.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Gilbert Walker
Centre for Biofouling Control
Biofouling is the undesirable accumulation of microorganisms, plants, and animals on wetted surfaces. For marine
applications, the Centre for Biofouling Control will focus on developing materials that prevent biofouling without bringing
environmental risks, in the applications for ship hull and aquaculture net engineering. Furthermore, the infrastructure
will enable the development of materials that are no more expensive than current toxic heavy metal approaches. The
currently used copper based system is becoming restricted across the world, but no useful alternative exists yet. For
biomedical applications, the Centre will focus on creating low biofouling biomaterials for healthcare that reduce the
development of undesired biofilms. This will lead to better dental, cardiac, and orthopedic care, as well as better
molecular diagnostics platforms.

Several pieces of technology to monitor biofouling growth will be bought: an imaging surface plasmon resonance
instrument to quantify protein deposition, a video system to observe settlement of organisms on marine fouling
surfaces, an environmental atomic force microscope to characterize the morphology and mechanical properties of the
fouliant, and a nanoscale IR imaging system to evaluate chemical composition and structure
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Melanie A. Woodin
Multiphoton Microscopy for Live-Cell High-Resolution Imaging
The molecular biology revolution of the last century accelerated cell biology discoveries at an unprecedented rate. But
if we want to understand how living organisms develop and function, we need to move beyond the level of the individual
cell, and discover how cells communicate. Neurobiology is a prime example; many of the individual components of the
synapses have been identified, but the role these molecules play within brain circuits is not clear. In the same way that
the molecular biology revolution was driven by the development of techniques to study genetic material, the
development of advanced microscopy methods, which allows the 3- and 4-dimensional imaging of living cells, is set to
revolutionize our understanding of how cells communicate.

We are requesting funds for the purchase of a multiphoton microscope dedicated to the translation of cell biology
research to living organism function; the requested microscope would represent a new technological platform for a multi-
user facility at the University of Toronto. Specifically, the requested equipment includes a microscope and its optics,
ultrafast titanium-sapphire lasers, and electrophysiological recording equipment.

To ensure optimal use of the requested infrastructure it will be located in the Cell & Systems Biology (CSB) Imaging
Facility, which is a multi-user facility available to researchers within the Department and across the University of
Toronto campus. This facility has the human capital required to supervise, maintain and make efficient use of the new
imaging equipment.

The primary Research Team requesting this imaging platform is a multi-disciplinary group of researchers who
established their laboratories with previous CFI- and Ontario- funded awards (Drs. Woodin, Tropepe, Tepass, Harris,
Bruce, and Winklbauer). Through their existing collaborations with researchers across the University of Toronto
campus, and their industrial ties, this Team is poised to address the fundamental research question: how does cell-to-
cell communication coordinate tissue formation and organ function?

The Research Programs that will be advanced by this multiphoton microscope are directly aligned under The University
of Toronto Strategic Research, which states that “The key to success of this strategy is to support the excellence of the
basic research within disciplines so that it can inform and in turn support thematic and problem-based interdisciplinary
research, as well as remain responsive to new areas of priority as they arise.” The core programs of the Research
Team are focused on basic research that will answer fundamental cell biology questions. These discoveries are
needed in order to direct targeted research in the applied health sciences and fulfill the goal of the Ontario’s Innovation
Agenda to provide Strategic Support for Knowledge Creation.

The output of this investment will be a significant increase in the quality and quantity of peer-reviewed research, which
will have both immediate and longer-term impacts on Ontarians. Immediately it will lead to job creation and enhanced
training of existing HQP, and in the longer term, the discoveries made will form the basis of improved health and
commercialization in the health-care industries.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): Mark Lautens
Centre for Chemical Analysis
Chemistry stands at the crossroads of many branches of science, engineering and medicine and both touches and is
touched by the key issues facing mankind. The Chemistry Department at the University of Toronto is one of its flagship
units and the work done in the Department is internationally recognized as being of the highest calibre. Our faculty
members are tackling the pressing problems in environmental and biological chemistry, catalysis, materials science
and energy, while employing a diverse range of tools and methods. Addressing the most important questions in science
and technology requires tremendous infrastructure investment. The CFI has been a linchpin in helping us achieve our
lofty goals. Construction of the Davenport Wing, the cornerstone of infrastructure improvements, was enabled by
matching funds from the CFI. Subsequently (in 2009), with funding from the CFI, we were able to upgrade our Nuclear
Magnetic Resonance (NMR) equipment with the creation of CSICOMP (Centre for Spectroscopic Investigation for
Complex Organic Molecules and Polymers).

While NMR is a core technology, it remains only one part of our daily molecular characterization efforts. ANALEST is
our go-to facility for day-to-day characterization using methods other than NMR. More than 15 years ago ANALEST
was created to assist researchers in environmental science but the user pool currently includes many key players in
chemistry, forestry, engineering, and dentistry. The current facility, while once cutting edge, has become outdated and
can no longer support frontier areas from a pool of users that has considerably expanded and broadened in scope. We
must dramatically expand this facility with new equipment that allows interdisciplinary studies in chemistry, engineering,
forestry, dentistry and biomedical research.

This request is for a suite of equipment that in total will address the most pressing scientific issues in Chemistry as well
as in many other departments across campus. The Chemistry PI's, their students, as well as a number of other
researchers from Departments in Engineering, Medicine, Pharmacy, Forestry and Dentistry, use ANALEST and require
a central facility for the latest technology in analytical instrumentation. We are requesting chemical separation and
analysis instrumentation composed of a GC-MS system, an FTIR, a TOC-TN analyzer, an SFC system, a UV-VIS-NIR,
an ICP-MS system, and a Raman microscope. This center will be instrumental in our ability to attract private sector
funding to support our ambitious research commercialization initiatives. MaRS Innovations, Ontario Institute for Cancer
Research, and Ontario Genomics Institute have already made large investments in our recent research. Our ability to
sustain this momentum hinges on access to world-class chemical analysis infrastructure, which is currently lacking.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Toronto
Ms. Mayliza Baak, Director, Institutional Initiatives
Phone: (416) 978-7605
E-Mail: m.baak@utoronto.ca

Lead Researcher(s): George Eleftheriades
TeraLab: Centre for Energy-Efficient Terascale Communications Platforms
Computing and communications are on the cusp of a revolution. Today, computing is agile, mobile, and always-on,
carried out by ultra-portable devices such as smart phones, tablets, and laptops that communicate with each other and
with the Internet. This is driving myriads of applications, from social networks to on-demand entertainment, that are
transforming societal productivity and human interactions. This proliferation of mobile computing is ushering the cloud
computing paradigm, where devices access data and services in the “cloud” via the Internet. Examples of the cloud
computing model are Google, iCloud, and enterprise services. In addition to changing the way we live, cloud
computing also offers an unparalleled potential to enhance our quality of life. Data collected by mobile devices can be
sent to the cloud and analyzed to optimize complex systems, such as traffic flows and power distribution in real-time.
This can dramatically improve the efficiency of cities, organizations, and the use of resources.

Despite the transformative opportunities of cloud computing and interconnectivity, the information and communications
technology (ICT) sector is on a collision course with unsustainable power consumption. Physically, the cloud consists of
large-scale computing systems known as datacenters where the computing needs of millions of people are
consolidated and shared. Datacenters consume more than 220 billion kWh of energy per year, and this consumption is
growing by more than 10% annually. Simultaneously, Internet data traffic is growing at 34% per year, corresponding to
an exponential increase in the volume of data that must be processed and communicated in and between datacenters.
New technologies are required to curb this energy consumption while supporting unprecedentedly large data
communication rates.

The proposed facility, TeraLab, addresses these critical challenges in ICT by bringing together researchers across
multiple disciplines to investigate technologies for energy-efficient terahertz and terabit per second communications
(tera = 1012, i.e. 1 trillion). TeraLab will renew 25% of the existing CFI and Ontario-funded facilities in the Department
of Electrical and Computer Engineering at the University of Toronto to create a world-class facility for energy-efficient
ICT research. The facility will enable electronics, electromagnetic, photonics, and communications researchers to
collaborate and develop the next generation of electronics, wireless links, optical devices, information processing
techniques, and networks necessary to overcome the energy and data grand challenge of ICT. The timing is urgent for
TeraLab because fundamental advances in nanoscale electronic devices, integrated photonics, material composites,
and the control of electromagnetic radiation are prime for convergence to create innovative solutions for the
environmental and fiscal sustainability of ICT.

TeraLab will benefit Ontario and Canada by training highly qualified personnel (HQP) and developing energy-efficient
technologies for ICT. TeraLab will support the training of > 100 HQP annually for a sector that has an internationally
renowned record of strength, wealth generation, and innovation in Ontario. In addition to stellar research
achievements, the team has a strong record in intellectual property and commercialization. TeraLab will leverage from
the many existing domestic and international partnerships with industry, consortia, universities, and research institutes
established by the research team. It will also generate new partnerships and alliances to facilitate technology transfer,
enhance training opportunities, and elevate the international scientific profile of the University, province, and country
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Waterloo
Mr. Andrew Barker, Director, Institutional Programs
Phone: (519) 888-4567 x 36004
E-Mail: andrew.barker@uwaterloo.ca

Lead Researcher(s): Chris Eliasmith
Theoretical and experimental investigation of the biological basis of cognition
Changes in the brain take place over a multitude of spatial and temporal scales: single ion channels in neurons open
and close in nanoseconds; electrical waves constantly traverse the complex neural networks that make up the brain in
milliseconds; and the brain literally rewires itself over minutes, days and years.

Unfortunately, modern experimental methods used to probe the neural mechanisms underlying cognition trade off
information about precise timing for information across spatial scales. Functional magnetic resonance imaging (fMRI)
is notoriously slow, but can localize sub-millimeter activity throughout the entire brain. Single or multi-neuron physiology
provides sub-millisecond and highly localized information, but does not address large network activity as directly as
fMRI. Major advances in understanding brain function, especially at the level of human cognition, require improved
resolution of experimental methods and, critically, a means of integrating results across new and existing methods.

Leading edge research at Waterloo’s Centre for Theoretical Neuroscience (CTN) has resulted in a unique set of
theoretical methods permitting construction of the largest and most detailed neural models of cognitive behaviour
currently available. In the proposed project, these methods will be leveraged to construct a single, unified model that
can be simulated at many levels of biological detail, while performing a wide variety of behaviourally well-characterized
functions. To construct such a model, constrain it with appropriate neural data, and test it rigorously, our team will focus
on three main objectives:
1) employ state-of-the-art modeling methods and specialized computing hardware to build extremely large-scale (~10
million neuron) models at the level of single neurons and below;
2) implement a unique-in-Canada high-density single cell recording system to develop and test the model with large-
scale single cell data; and
3) exploit industry support to develop and use an as-yet-unavailable high-resolution fMRI system for functional and
structural research on human subjects, to develop and test the model on cognitive tasks.

The proposed includes a specialized computing platform (10,000 ARM9 processors, $200,000), a high-density 512
channel single cell recording system ($250,000), and an fMRI scanner with custom Tornado digital sensors
($2,595,000). Expected renovation costs to house the infrastructure are $500,000. Each of these systems will be
unique in Ontario and Canada.

This facility and the research that it supports will benefit the development of novel medical technologies and medical
interventions in Ontario. The methods developed to inform the model will significantly speed up acquisition of MRI
signals for structure-related brain scans. In addition, the model itself will be tested on interventions for diseases such as
Parkinson’s (e.g. deep brain stimulation), hemineglect (e.g. visual prisms), and addiction (e.g., dopamine regulation).
Together, these diseases affect over 1.2 million Ontarians.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Waterloo
Mr. Andrew Barker, Director, Institutional Programs
Phone: (519) 888-4567 x 36004
E-Mail: andrew.barker@uwaterloo.ca

Lead Researcher(s): Ian Goldberg
Privacy Enhancing Technologies at a Global Scale
This project seeks to acquire leading-edge equipment to develop large-scale testbeds for experimentation on the next
generation of privacy-enhancing technologies (PETs). The three technologies we focus on are: private information
retrieval (PIR), which facilitates privacy-preserving queries over online databases; anonymous communications
networks, which enable Internet users to browse the web and communicate privately; and censorship-resistant
communications infrastructures, which promote free speech and access to information for all citizens worldwide. These
technologies are of growing importance in a world where governments, companies, and Internet service providers
routinely profile people's behaviour, and even explicitly block access to certain parts of the Internet — they provide a
way for people to protect their freedoms in an increasingly online world. This in turn fosters an environment in which
users feel more secure with an online presence, leading to valuable promotion of and support for e-business and e-
government in our province.

Significant improvements to these technologies will emerge as a result of this project. PIR has only recently been
shown to be feasible for real-world use, and significant work remains to make Internet-scale deployment practical.
Anonymous communications systems, conversely, are widely deployed, but their current designs suffer from scalability
and performance problems. Fixing these problems is difficult, because experimentation on a live network jeopardizes
the safety of its users, and no large-scale testbed exists for running realistic simulations in a safe environment.
Additionally, recently proposed approaches to censorship resistance have not been evaluated on the Internet at a
meaningful scale. With access to large-scale testbeds for these technologies, we expect to significantly advance the
state of the art in PETs, and thus greatly improve the privacy landscape for Internet users in Canada and abroad.

Each respective testbed requires highly specialized equipment, summarized as follows.
1. Private Information Retrieval: PIR experimentation requires much processing power and fast secondary storage. Our
testbed will require a cluster of PIR servers composed of many CPUs and GPUs with diverse architectures. Together
with fast, solid-state storage devices, the testbed will achieve unprecedented performance and deployment scales.
2. Anonymous Communications: Replicating the scale and traffic composition of global-scale anonymity networks
requires a cluster of commodity servers with high-performance reconfigurable networking, multicore CPUs, and large
amounts of memory.
3. Censorship Resistance: Recent approaches leverage deep packet inspection (DPI) techniques, which necessitate
specialized networking devices with DPI and cryptographic capabilities that can manipulate and perform cryptographic
operations on massive volumes of Internet traffic.

The proposed facility and research developed therein will provide many benefits to Ontario, and will re-enforce the
University of Waterloo and the Province of Ontario as leaders in Internet privacy by helping shape the next generation
of PETs. Cutting-edge testbeds for tomorrow's PETs will attract top students, postdocs, and faculty, and will equip them
with a unique skill set needed to build and operate these and related technologies. Our project is well positioned to lead
to commercialization, with applications to Ontario-based companies like Sandvine, RIM, and Certicom that create the
technologies underlying the global communications infrastructure.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Waterloo
Mr. Andrew Barker, Director, Institutional Programs
Phone: (519) 888-4567 x 36004
E-Mail: andrew.barker@uwaterloo.ca

Lead Researcher(s): J. Honek
Materials Bioprospecting Facility
Nature is a primary source of substances and designs, and has been the inspiration for many innovative materials.
From Velcro fasteners (modeled on the attachment mechanism of burrs) to low drag fabrics used by Olympic swimmers
(modeled on shark skin), novel materials have been developed based on mimicking or directly utilizing biomaterials.
Other examples include adhesive surfaces, anti-reflection coatings, biobatteries, and biophotovoltaics, all modeled on
naturally occurring systems. Advances in nanotechnology and green chemistry have increased demand for
development and application of novel biomaterials.

Natural systems have had billions of years of evolutionary pressure to become highly optimized and efficient, often
produce minimal waste, and do not require high temperatures or the use of toxic solvents for their synthesis. Given the
multitude of species in existence there is vast potential for further discovery of naturally occurring materials and designs
critical to Ontario industry. We propose to establish a Materials Bioprospecting Facility (MBF) at the University of
Waterloo for the exploration and development of novel biomaterials, aided by state-of-the-art technology for biomaterial
analysis and high-throughput data collection. This facility would build upon current strengths in nanotechnology and
materials science at the University of Waterloo, and would establish Waterloo as an international centre for
bioprospecting research.

The core requested infrastructure includes mass spectrometry equipment for analysis of biomaterials including
metabolites, proteins, and biomolecular complexes, a system for fluorescence assisted cell sorting, and a DNA
sequencer for obtaining high-throughput genome and gene expression data. Two mass spectrometers are requested:
the first is a high-sensitivity system equipped with multi-dimensional (2D) nanoLC for separation of sample limited,
complex mixtures and a high flow rate HPLC system for high throughput applications (e.g. Thermo Scientific Orbitrap
Elite). The second is a MALDI TOF/TOF for two-dimensional imaging of biomolecular distributions (e.g. ABSciex 5800).
These systems would provide a versatile platform for analysis of biomaterials and characterization of complex
biomolecular structures including peptides, proteins, carbohydrates, metabolites, and other (bio)chemical species. For
collection of genomic sequence data, a high-throughput, high accuracy DNA sequencer is requested (e.g. Illumina
MiSeq). To complement the above systems, a Fluorescence Activated Cell Sorter (e.g. BD Biosciences FACSAria III) is
requested to facilitate cell and materials isolation via fluorescent labeling of molecules and cell surfaces prior to mass
spectrometry and sequence analysis.

The identification of the fundamental structure of biomaterials such as bioadhesives, biofibers applicable in the creation
of new “smart” textiles, and multiprotein complexes capable of serving as molecular frameworks for biobatteries and
biophotovoltaics will contribute to high-end manufacturing industries in Ontario, including textiles, adhesives, low-
friction surface materials and energy industries. Identified components may also be applied to replace environmentally
harmful materials, such as fossil-fuel based synthetic materials that rely on toxic organic solvents for processing. MBF-
based research will also provide molecular blueprints for bottom-up creation of leading-edge manufacturing materials
such as electronics and material composites. These areas currently lag in the application of ecofriendly biomaterials as
structural components and will provide a transformative change in the way we fabricate these materials.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Waterloo
Mr. Andrew Barker, Director, Institutional Programs
Phone: (519) 888-4567 x 36004
E-Mail: andrew.barker@uwaterloo.ca

Lead Researcher(s): Thomas Jennewein
Facility for Global Quantum Communication and Security Certification
The emerging technologies of quantum information have the potential to change our methods of processing and
communicating information. One of the nearest term – and therefore most important –applications is to implement a
highly secure quantum key distribution (QKD) system by sending individual particles of light, called photons, between
two user locations.

The requested infrastructure consists of a specialised laboratory for research on the operation, security testing and
certification of various types of QKD systems. This research will tackle some of the most crucial and interesting
challenges for quantum photonics technologies, and bring them closer to real-world applications. We will advance
attainable point-to-point distances for quantum communication far beyond the current limit of 150 km, to global scales –
by using satellites. The design and concept of a Canadian quantum satellite mission is currently pursued by the
Canadian Space Agency under the lead of the Institute for Quantum Computing at the University of Waterloo in
collaboration with our industry partner COMDEV. The requested infrastructure provides an optical ground station
capable of quantum communications with satellites and will enable the team to develop and operate prototype systems
for the satellite payload and demonstrate their viability. Once the satellite mission is launched, the infrastructure will be
utilized as a ground station for performing experiments with the satellite. The infrastructure will also be compatible for
quantum communication experiments with possible other quantum satellites from partnering nations, including
ESA/Europe or Japan, or even future commercial satellite systems.

We will address the physical behaviour and weaknesses of QKD implementations due to real-world imperfections in
actual devices, in particular photon detectors. These intense studies will employ state-of-the-art methods for proofing
against any possible practical attacks on the communication channel and other weaknesses, and introduce certification
standards for QKD systems. The requested infrastructure will test and characterize all optical and electrical signals
entering or leaving any practical QKD device with very high speed and precision. This data will then be analyzed to
determine the security of the QKD system.

The team of principal users is a collaboration of Dr. Thomas Jennewein, an expert in long-distance quantum
communications and Principal Investigator for the Canadian satellite mission; Dr. Vadim Makarov, a world-renowned
expert in the practical security of QKD systems, Dr. Norbert Lütkenhaus, a world authority on the security of practical
QKD devices, and Dr. Michele Mosca, a pioneer in the testing of untrusted quantum apparatus.

The infrastructure will benefit Ontario, through the unique opportunity to lead the world in this technology. Significant
interest exists from industrial partners, in particular COMDEV in Ontario, and active partnerships are established.
Deploying the technologies for satellite quantum communications and security certification in Ontario will provide a
leading edge to the industry because of the high potential for market application of these technologies as well as the
training of personnel in quantum communication skills, including photonics, laser and satellite technologies. This project
will propel Ontario’s high-tech industry into the information age of the 21st century.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Waterloo
Mr. Andrew Barker, Director, Institutional Programs
Phone: (519) 888-4567 x 36004
E-Mail: andrew.barker@uwaterloo.ca

Lead Researcher(s): Richard . Hughson
Research Institute for Aging: Program in Brain Health and Successful Aging
The proposed infrastructure project will provide an opportunity to advance several interconnected themes with a
primary focus to enhance brain health and improve the quality of life in the elderly.

In Theme 1, the physiological (vascular and neurophysiological), nutritional and pharmacological factors that
collectively impact “Determinants of brain health” will be quantified by high precision, non-invasive technologies
including ultrasound of brain blood vessels (real time, portable, and ambulatory monitoring), measurement of arterial
properties (ambulatory and clinical blood pressure, and arterial stiffness), heart rate (ambulatory Holter monitoring),
transcutaneous blood gases, and near infrared spectroscopy investigations of tissue oxygenation (multi-lead and
ambulatory). Functional neurophysiological assessments of motor control will be made with state of the art motion
sensing devices and force plates. A metabolic kitchen will allow for nutrition intervention studies while the impact on
metabolites, blood nutrients and biomarkers of vascular and brain health will be quantified by highly specific, targeted
analyses using tandem mass spectrometry coupled to high performance liquid chromatography. Body composition will
be measured using non-invasive impedance technologies and dual energy x-ray absorptiometry

In Theme 2, new “Health sensor technologies” will be developed to enhance the studies of Theme 1 by enabling
creation of a ‘movie’ of everyday health rather than the ‘snapshot’ from a usual clinical visit. Researchers will design
and implement novel wearable, implantable and built environment sensors incorporating wireless technology to monitor
individual physical contributors to daily life. The high precision measurements of multiple biomarkers of vascular and
brain health outlined in Theme 1 will be complemented by new ‘lab-on-chip’ technologies that will permit low-cost,
widespread access to key markers of health.

In Theme 3 “Models of time-varying health”, the fundamental understanding and sensor technology developed in
themes 1 and 2 will be used to develop new models to predict onset and progression of brain disease within individual
people. These models can be the foundation for personal health decisions as well as inform population health decisions
and policies.

In Theme 4 “New therapies and assistive technologies”, the models developed in theme 3 will guide development of
novel therapeutic and assistive technologies to facilitate personal independence and reduce the burden on
conventional health care components. Prototypes will be tested in long-term care and retirement facilities that are part
of the Research Institute for Aging.

The proposed infrastructure will support the unique convergence of expertise in biology, engineering and computing
with allied health partnerships to permit a new opportunity to rapidly translate and implement new diagnostics,
technologies and therapies. The hub for research and development and on-site testing with a ‘living lab’ at the
University of Waterloo will link highly sensitive diagnostic and therapeutic models to our research colleagues at
neighboring institutions and to Family Health Teams in satellite locations serving communities of older adults across
Southern Ontario as a proof of concept before nationwide implementation.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Waterloo
Mr. Andrew Barker, Director, Institutional Programs
Phone: (519) 888-4567 x 36004
E-Mail: andrew.barker@uwaterloo.ca

Lead Researcher(s): Tong Leung
Ontario Materials Technology: Harnessing the power of strategic multifunctional
materials in their natural state for emerging technologies
The Ontario Materials Technology (OMT) centre is based at the University of Waterloo, with participating researchers
from Wilfrid Laurier University, University of Guelph, University of Toronto, Queen’s University, and University of
Ottawa. OMT seeks to establish a high-impact technology hub to accelerate multidisciplinary research in materials
technology. OMT will concentrate on three of the four Ontario focus areas, with the goal to construct new materials and
prototype devices in three dimensions and to conduct rapid screening of new materials in their natural state and under
stimuli (light, electrons, ions, pH, humidity, local environmental conditions).

• Clean technologies: Low-cost solar-cell devices based on transparent conductive oxides on plastics to provide a
clean-energy alternative to Ontario; new battery materials for integrating into Ontario’s automobile and other
manufacturing industries; advanced geomaterials to protect Ontario’s groundwater resources and to remediate
contaminated sites; new photocatalysts for removing CO2 and other greenhouse gases to assist Ontario industries with
reducing their carbon footprint.
• Advanced health technologies: Ultrafast-response biosensors (based on transparent conductive oxide nanomaterials)
for monitoring blood sugar (for diabetes patients) and cholesterol levels; microfluidic devices for advancing drug
delivery and health monitoring technologies in Ontario; advanced ocular materials for extra-comfort contact lenses for
Ontario’s over-one-million contact lens wearers; novel carbon-nanotube-based sensor systems for real-time monitoring
of air-borne and water-based pathogens to protect Ontario’s public places (schools, hospitals, transit systems, airports,
shopping malls, sport arenas).
• Information and communications technologies: Low-cost spintronics materials (to facilitate information manipulation
based on not just the electron charge but also the electron spin); three-dimensional flexible electronics to advance
Ontario’s next-generation start-ups in communications and information technologies.

In addition, OMT researchers will also be developing photonic crystals and chiral composite materials for optics,
forensic and chemical-sensor applications; hybrid nanoparticles for use in paints and cosmetic industries; and new
smart coating technology and hybrid catalysts for Ontario’s diverse manufacturing sector.

In order to achieve its goal, OMT requires three tools:
(1) an Ion Beam Lithography system for precise three-dimensional nanopatterning and nanofabrication of novel devices
using advanced ion beam technology;
(2) an Atmospheric Scanning Electron Microscope for high-resolution imaging of materials and cells in air or liquid,
and/or under external stimuli in real time, and (3) an Environmental Correlative Light and Electron Microscope with the
new “shuttle & find” technology for structural and compositional analysis to enable rapid screening of new materials in
their natural state.

All of the proposed tools are unique in Canada and will offer Ontario researchers unprecedented opportunities to make
new discoveries in multifunctional materials research not possible before. Together with the research tools previously
supported by the Province of Ontario and CFI (Projects #747 and #4808), these new tools will also provide a hands-on
training environment for Ontario students in a wide range of state-of-the-art instrumentation technologies second to
none in Canada. With Waterloo serving as the technology hub, the established interactions among the six participating
Ontario institutions will provide an excellent network of state-of-the-art resources for multidisciplinary materials research
to support the diverse manufacturing and high-tech industries in Ontario.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Waterloo
Mr. Andrew Barker, Director, Institutional Programs
Phone: (519) 888-4567 x 36004
E-Mail: andrew.barker@uwaterloo.ca

Lead Researcher(s): John McPhee
Smart Powertrain Research Facility
Research:
Technological innovation in today’s automotive industry is largely driven by the need to meet strict fuel efficiency and
emissions targets. Greater market penetration of vehicles with advanced electric, hybrid-electric, and optimized internal
combustion engine powertrain systems can accelerate achievement of these goals. There is a unique opportunity for
the University of Waterloo (Waterloo) to undertake world-class research in this area through establishment of an
industry-grade Smart Powertrain Research Facility (SPRF) for large-scale vehicle testing, with support from Toyota.
The requested infrastructure will help establish a Centre of Excellence where automotive and parts manufacturers can
access state-of-the-art equipment and research expertise to further advance their conventional, electric-, hybrid-electric
and plug-in hybrid electric vehicle (EV, HEV and PHEV) technologies. The new infrastructure will be used as a test
platform to collect experimental data needed for verification and fine-tuning of new system designs, where physical
hardware for the engine, transmission and their electronic control units (ECUs), electric motors, super-capacitor or
battery are integrated with simulation models for the driveline, wheels, vehicle body dynamics, traffic flow, driver, and
wireless sensors. It will also enable implementation of new wireless communication systems for route-based predictive
control strategies for EVs and PHEVs. New testing capacity will be extended to the evaluation of on-board sensors,
batteries and power electronics systems, as well as smart control strategies for both conventional vehicles and the full
range of HEV architectures.

Equipment:
The proposed SPRF will provide the flexibility and modularity needed for world-class powertrain testing to industry-level
quality. Three core systems will be integrated to enable a comprehensive vehicle testing capability:
1) powertrain test cell,
2) full vehicle test cell, and
3) battery test platform.
The powertrain test cell will consist of a three dynamometer setup, battery simulator, real-time simulation system, data
acquisition and test control systems, and accurate emission and fuel measurement systems. It will also include
complete environmental control and cooling systems for test specimens. The full vehicle test cell will include an electric
four-wheel drive chassis dynamometer and wheel force sensor systems. The battery testing platform will include a
programmable power supply, air and coolant conditioners, a single cell battery cycler, an environmental chamber, a
potentiostat and a thermal camera.

Benefit to Ontario:
The requested infrastructure will support new breakthroughs in powertrain efficiency through optimized components,
configurations and control systems that make intelligent decisions based on information received from in-vehicle and
infrastructure-based sensors. These technologies will yield significant improvements in fuel, power and transportation
efficiencies, as well as optimized battery life, comfort, safety and travel-times, which will in turn reduce harmful
emissions. Research results will pave the way for new automotive technology development, and will enhance Ontario’s
academic profile through advances in model-based design, optimization and control strategies, and wireless
communication systems. It is expected that close proximity to major testing and evaluation infrastructure will strengthen
existing partnerships and facilitate new collaborative opportunities with Ontario automotive companies, opening direct
channels for technology transfer and commercialization in Canada.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Waterloo
Mr. Andrew Barker, Director, Institutional Programs
Phone: (519) 888-4567 x 36004
E-Mail: andrew.barker@uwaterloo.ca

Lead Researcher(s): Stephen Murphy
Long Term Ecosystem Change and Resilience Living Laboratory
Using the infrastructure, we will conduct comprehensive, long term studies that assess ecosystem change in an area
that is still relatively pristine yet is being affected by such issues as regional climate change, logging, and rapid
population change that is leading to increased urbanization and tourism impacts.

We will design and build a fleet of remote thermal cameras. They will be used to assess thermodynamic based
differences that assess ecosystem states and functions. This technology is based on advanced theories from the fields
of ecology, geography, physics, environmental and mechanical engineering. The new camera technology will
revolutionize ecosystem assessment and is one outcome of the work – new technology capable of large scale
assessment and action on land use management under the rubric of examining long term ecosystem changes and
resilience. The requested cameras can be mounted on full sized airplanes or small drone airships to assess landscape
scale ecosystem change across areas up to 1,000,000 km

2. We also request funds for ground based environmental stations to be established throughout the region to ground-
truth the remote data, i.e. provide detailed, long-term data on key parameters associated with long-term ecosystem
change in terrestrial, aquatic, and riparian zones (measuring light attenuation, nutrient flows, water dynamics). We also
are requesting 2-4 small vehicles secured to access remote locales for data collection and maintenance. We also
request infrastructure to examine fine-scale ecosystem responses (e.g. nutrient flows and water quality) in more
controlled and mass-processed conditions include high performance liquid chromatography, gas chromatograph-mass
spectrometer growth chambers, and nuclear magnetic resonance. The equipment will be located at the new $16.2
million U Waterloo Centre for the Environment at Huntsville ON.

Ontario’s Innovation Agenda demands “the creation of innovation and private sector partnerships”. With the private
sector, we wish to build the cameras and then market and mine the data for public and private sector demands -
planning for climate change adaptation, best practices to mitigate damage from resource extraction, protecting source
water and optimizing the combination of land development and greenspace. This further dovetails with Ontario
Innovation Agenda goal to “create green sources of energy, and development compatible with environmental goals”.
The proposed infrastructure will require (per the Agenda) “community partnerships and economic cooperation” in areas
that have been harmed by recent recessions and by declines in traditional manufacturing and resource extraction
industries. Specifically, we will need local manufacturing for the technology and highly qualified personnel in the
industries and communities to build and properly use the technology and the data to their benefit. By spurring
“development in a socially and environmentally responsible manner” (again, per the Agenda), a process and technology
set will be established for assessing and adapting to long term ecosystem changes that can be adopted in other
regions. Congruent with the Agenda, there is demand in the tens of thousands for highly qualified personnel who can
identify, evaluate and monitor long term ecosystem changes as this relates to promoting development of resources in
an environmentally sensitive manner.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Waterloo
Mr. Andrew Barker, Director, Institutional Programs
Phone: (519) 888-4567 x 36004
E-Mail: andrew.barker@uwaterloo.ca

Lead Researcher(s): Linda F. Nazar
Energy Materials Centre
As the world strives towards a new energy economy based on sustainable resources, the necessity to develop efficient
materials to generate renewable energy - to store that intermittent energy energy in low-cost, high energy density
systems built from environmentally friendly elements - and to sustain efficient energy consumption - are all needs that
are bound to increase in demand. The consumer adoption of market-competitive hybrid electric vehicles is completely
reliant on the development of advanced energy storage batteries to power them. On a widespread level, this would
minimize the impact of urban pollution and diminish petroleum consumption. Any platform for such energy management
described above fundamentally relies on materials to enable the advancement of the technology, and engineering to
integrate them into next-generation devices. The research in this project is devoted to that aim. Our application is in
support of infrastructure to establish an Energy Materials Centre (EMC) at UW. The centre will promote a broad-
spectrum project devoted to materials for energy storage, conversion and efficiency, and the development of prototype
devices that rely upon them. It would set Ontario apart as having one of the world’s leading facilities devoted to energy
materials science and engineering, which will offer researchers an unprecedented breadth of study in this emerging
field that will shape the future. This would place us in a unique and timely position. To our knowledge, there is no other
program in Ontario with this broad mandate, although many endeavours are quickly arising in the USA and Europe, as
the importance of becomes apparent worldwide. The resources within the facility will establish a centre of innovation in
this area in Ontario. It would attract outstanding young scientists and industrial contracts, act as a catalyst for
commercialization and generate IP that can contribute to spin-off companies - all outlined priorities in the Ontario
Innovation Agenda. The peer-reviewed research/technology excellence that would be its outcome is in full keeping with
creating a cleaner environment and ensuring a global competitive advantage.

The Centre’s research will broadly encompass energy materials technologies that include next-generation devices for
energy storage batteries, energy conversion (thermoelectrics and photovoltaic), and energy efficient solid state lighting.
These high performance systems require the design and fabrication of highly advanced materials/nanomaterials for
their components and the interfacing of many disparate chemistries ranging from inorganic to polymers to
semiconductors. The interdisciplinary nature of the projects will allow us to learn how to harness and manipulate
chemistry in accord with materials science and engineering and develop new materials unrivalled in the present day.
The proposed infrastructure will combine tools for advanced materials processing; computational modeling to guide the
search for new materials and advanced microscopy and diffraction facilities to unravel their structures, and the
development of new engineering device architectures for next-generation rechargeable energy storage batteries and
electrochemical cells, solid state lighting, thermoelectric devices, printed organic electronics, and supercapacitors for
high-power energy delivery. It will enable characterization of both the microstructural and optoelectronic properties of
these nanomaterials, and device fabrication and testing.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Waterloo
Mr. Andrew Barker, Director, Institutional Programs
Phone: (519) 888-4567 x 36004
E-Mail: andrew.barker@uwaterloo.ca

Lead Researcher(s): João B. P. Soares
Soft Materials Synthesis, Characterization, and Testing Facility
Soft materials such as advanced polymers and elastomers are essential to several of Ontario’s most vital economic
sectors. For example, Ontario’s automotive and aeronautical industries are experiencing an increasing demand for
these materials because they directly contribute to vehicle weight reduction, allowing companies to address aggressive
fuel efficiency and green house gas emission targets in the near term. The fact that, when properly designed, soft
materials can be easily recycled and have minimal environmental impact adds to their attractiveness in these markets.
The proposed world-class facility will enable world-class synthesis, characterization, and testing capabilities required to
produce and understand soft materials. Ultimately, this work will help keep Ontario and Canada at the leading edge of
soft material development for engineering applications. Our central location in Canada will make this facility easily
accessible not only to researchers from the University of Waterloo, but also to external academic and industrial
collaborators with complementary interests, both in Canada and internationally. For example, planned academic
collaborators include CNRS-Lyon (France), University of Stellenbosch (South Africa), Federal University of Rio Grande
do Sul (Brazil), Concordia University and McMaster University. Industrial collaborators include Total Petrochemicals,
ExxonMobil, Dow Chemical, Chevron-Phillips and Sud-Chemie.

The new research infrastructure will combine equipment ranging from reactors for the synthesis of advanced new
polymers and composites, instruments for molecular architecture and morphology characterization, physical property
testing and compounding. All these elements are essential for the development of new soft materials. Availability of the
proposed state-of-the-art facility will permit the integrated and multidisciplinary development of new materials and
facilitate their commercialization by attracting industrial partners in Ontario and elsewhere to benefit from this wide
array of soft material development synthesis and characterization equipment. Building on existing capacity for polymer
synthesis and characterization funded by our previous CFI grant, the requested infrastructure will enable us to extend
our leading research on polymers and other soft materials with the acquisition of new state-of-the art equipment, such
as a reactor calorimeter set-up, polymer cross-fractionation infrastructure for detailed molecular characterization, and
compounding equipment. This will add a new dimension to our existing facilities, by extending it polymer synthesis
capabilities to include other reactor types and permitting their detailed molecular characterization, as explained in the
next section. It will also allow us to attract top graduate students that in the future will contribute to the industrial
development of Ontario and Canada. The requested infrastructure is critically important to maintaining Ontario’s
reputation as a leader in the highly competitive area of polymer research.

The main pieces of equipment required for the proposed infrastructure are grouped into the following major classes: 1)
Synthesis: modern chemical and polymerization reactors for the production of novel soft materials; 2) Characterization:
thermal, structural, imaging and microstructural characterization techniques equipment; and 3) Mechanical property
testing and compounding equipment.

In summary, the primary objective of this facility is to support the development of novel materials at both the laboratory
and industrial scales, by providing the applicants and their Canadian and international collaborators with the tools
needed to make them (Synthesis), understand their chemical structure and morphology (Characterization), and
determine and enhance their performance properties and final applications (Testing and Compounding).
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


University of Windsor
Dr. Ranjana Bird, Vice-President Research
Phone: (519) 253-3000 x3925
E-Mail: rpbird@uwindsor.ca

Lead Researcher(s): Daniel Heath
Environmental stressors in the Great Lakes: Assessment, functional analysis and
remediation
The Great Lakes hold >80% of North America’s fresh water, making these ecosystems critical for Ontario’s future.
However, many environmental issues impact the lakes and affect our ability to manage these lakes effectively. In the
past, we have managed lakes using issue-specific approaches addressing individual stressors as independent
processes. Because large lake ecosystems are facing multiple stressors (e.g., pollution, climate change, invasive
species, overexploitation, etc.) with complex interactions, it is critical to develop a novel multidisciplinary research
approach that capitalizes on the strengths and existing expertise at UWindsor and the Great Lakes Institute for
Environmental Research (GLIER-UW). This proposal enables researchers to assess, analyze and remediate stressors
threatening Ontario’s freshwater resources through integrated and innovative research.

Infrastructure Description:
Genomics/Proteomics: To build on the existing CFI/OIT Environmental Genomics Facility infrastructure through
expansion and development of proteomic and genomic capabilities, we are requesting;
1) a nano-ultra pressure liquid chromatography with quadrupole TOF mass-spectrometer to provide quantitative
identification of proteins and small environmental molecules.
2) a microarray printer and scanner designed for DNA-, protein- and tissue-based arrays,
3) a high-throughput nano-volume qRT-PCR thermalcycler,
4) a high-resolution, 5-laser cell sorting flow cytometer. This infrastructure will allow researchers to quantify the
functional role of aquatic stressors via gene-expression response, assess biomarker responses and toxicity implications
of emerging contaminants and diseases, and will provide novel tools for identification of, risk assessment, and control
of invasive species.

Ecosystem Tracers: The requested equipment will provide a cutting edge integrated system for quantifying
physiological and ecological characteristics of aquatic organisms and environmental conditions. Instruments include
those housed in the laboratory (stable isotope mass spectrometer for 34S and aquatic mesocosms) and in the field
(portable MRI, remotely operated aquatic glider, fish telemetry receivers and echosounder). The requested stable
isotope MS is a critical extension of existing stable isotope capacity used for biological samples, while the proposed
mesocosms (artificial streams & pools) will support functional trophic interaction and physiological analyses. The field-
based equipment will allow the assessment of organism movement, abundance, and biomass that will extend
biomarker data to trophic level impacts occurring at the population and community levels.

Biogeochemical Function Analysis: The requested equipment will augment the existing metals and biomaterials
laboratories with instrumentation upgrades, including a new solid state detector for the Environmental SEM, upgrades
to the laser ablation and elemental mass spectrometer, microelectrode array modular lander (lake sediment interface
studies) and an AFM/Raman microscope. This infrastructure will develop and enhance our capacity for assessing
ecosystem function and element cycling from the nano to organism scale, which will facilitate management and
remediation approaches using microbial community manipulation, provide decision support tools for sediment
remediation strategies and link genomic and ecosystem level research.

The multidisciplinary nature of this proposal, coupled with the breadth of expertise and history of collaboration of the
research team, will develop novel research approaches that will lead to an understanding of how aquatic stressors
interact on different temporal and spatial scales, and thus facilitate appropriate management approaches to mitigate
impacts from a variety of aquatic stressors.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Wilfrid Laurier University
Ms. Sally Gray, Manager Research Services
Phone: (519) 884-0710 ext 3528
E-Mail: sgray@wlu.ca

Lead Researcher(s): Masoud Jelokhani-Niaraki
Investigations on Biomolecular Structure, Function and Interaction
Studying cellular systems at the molecular level is fundamental for understanding life. The group of researchers
applying for this infrastructure grant share a common interest in understanding the molecular basis of biological
processes in bacteria, plants, and animals. The range of interests of these researchers encompasses areas such as
chemical synthesis of proteins, protein structure and function, neurodegenerative diseases (such as MS and prion
diseases), microbial genetic information and its protein and metabolite content, molecular aspects of environmental
inorganic matter contamination, mechanisms of biofilm formation, information processing in plants, intracellular protein
trafficking, and understanding the molecular mechanisms of the immune system in living organisms. Many of these
research areas at the molecular level share common concepts, methodologies and instrumentation that bind these
apparently distant disciplines together. The nature of biomolecular research is interdisciplinary and collaborative, and
sharing of knowledge, methods and instruments is already common practice within the Faculty of Science at Wilfrid
Laurier University.

The requested equipment, listed below, will complement and strengthen the existing infrastructure in the areas of
biochemistry, biophysics, molecular and cellular biology, and will provide the groundwork for establishing an
interdisciplinary “biomolecular research centre” at Wilfrid Laurier University. Acquiring the requested infrastructure will
significantly support and enhance the existing collaborations among the group of investigators who will be the main
users of the requested equipment and initiate new research collaborations within and outside the university. A strong
infrastructure for biomolecular research will also provide an invaluable opportunity for attracting high quality Canadian
and International graduate students and researchers to Wilfrid Laurier University. Currently, the Faculty of Science is in
the process of establishing a new Ph.D. program in the Biological and Chemical Sciences and the requested
infrastructure will be instrumental in developing and attracting students to this program. The wide range of expertise of
the user group of researchers (from biochemistry and biophysics to cellular biology and immunology) and the goal of
establishing a “biomolecular research centre” on the basis of the existing and requested infrastructure in the near future
will be in support of the priorities of the Government of Ontario in encouraging research and development in the areas
of health and environmental sciences. It is anticipated that the enhanced infrastructure at Wilfrid Laurier University will
significantly strengthen the research status of the Faculty of Science in the biological, chemical and health sciences.
The list of the infrastructure equipment and their estimated cost is as follows:

1) High speed preparative centrifuge for isolation and purification of biological samples
2) Refrigerated and temperature-controlled shaker/incubators
3) Flow cytometer for measuring proteins and their interactions within cells and organelles
4) MALDI-TOF mass spectrometer for complex biomolecular mass analysis
5) Dynamic light scattering instrument for size estimation of biomolecular complexes
6) Surface plasmon resonance instrument for detecting biomolecular interactions
7) Fluorescence spectrometer for studying biomolecular conformations and interactions
8) Differential scanning calorimeter for studying phase transition and thermal stability of biomolecules
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Wilfrid Laurier University
Ms. Sally Gray, Manager Research Services
Phone: (519) 884-0710 ext 3528
E-Mail: sgray@wlu.ca

Lead Researcher(s): Stephen Perry
Multidimensional research approach to promote healthy aging and mobility
With an increasing population of older adults the demand on the Canadian health care system will continually increase
unless appropriate methods to identify age-related disability are developed and specifically designed preventative and
rehabilitative strategies are put into action. The specific areas of research development that will take place under this
infrastructure project will involve understanding the age-related changes in dynamic balance control, degenerative disc
disease, health correlates with motor control related to laterality, neuromuscular fatigue and physiological efficiency.
Three-dimensional motion analysis systems will be essential to clearly establish and identify the subtle age-related
changes in dynamic balance control, movements indicative of degenerative disc disease, neuromuscular fatigue and
the affect of aging on laterality and motor control. Equipment capable of measuring muscle activity will be necessary to
understand the age-related changes in muscle activation patterns when degenerative disc disease is present.
Specialized muscle strength testing equipment will be used in conjunction with existing indwelling motor unit recording
equipment and a transcranial magnetic stimulation system to further the understanding of age-related neuromuscular
fatigue. Additionally, portable metabolic and motion sensors will enable evaluation of physiological efficiency with
respect to the activity performed. These measurement systems will all be utilized to develop and evaluate potential
interventions (preventative or rehabilitative) that could slow or prevent age-related decline in the research foci
presented here. The benefit to Ontario would be found in reduction in fall related injuries (through dynamic balance
control interventions), improvements in quality of life and worker performance (interventions to reduce lower back pain
or reduce susceptibility to neuromuscular fatigue or optimize physiological efficiency) that would reduce the need for
hospitalization and reduce the direct health care costs as a result of preventing injuries.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


Wilfrid Laurier University
Ms. Sally Gray, Manager Research Services
Phone: (519) 884-0710 ext 3528
E-Mail: sgray@wlu.ca

Lead Researcher(s): Matthew Smith
From Protein to Ecosystem: Infrastructure for the Examination of Biotic Interactions
Across Multiple Scales
Biotic interactions are interactions between biological molecules, organisms, populations, and ecosystems. Not only are
they fundamental to the survival and fitness of organisms themselves, biotic interactions determine ecosystem health
and ultimately govern ecosystem function. Plants are integral to the provisioning of key ecosystem services ranging
from carbon sequestration and biomass production to nutrient cycling and air and water purification. Maintaining and
enhancing these services requires an understanding of plant biotic interactions across scales. For example, alterations
in key physiological processes can scale up to reduced ecosystem capacity to provide valued ecosystem services.
Similarly, differences in metabolic pathways that function at the molecular level may underlie differential responses of
plants to biotic and abiotic stress. Through a series of recent targeted hirings emphasizing biotic interactions, Plant
Biology at Wilfrid Laurier has grown considerably and is currently comprised of six core faculty members.

With dynamic research programs ranging from metabolic processes (respiration, photosynthesis and nitrogen fixation),
to symbiotic associations, and determinants of plant community structure to the drivers of ecosystem functioning,
Laurier researchers are poised to examine biotic interactions at multiple scales. While we possess the majority of the
equipment to conduct key field and laboratory studies, we lack the necessary plant growth facilities to conduct critical
controlled environment studies that would better link these research areas and integrate our diverse research
programs. The requested infrastructure will facilitate this integration and lead to further collaborations aimed at
addressing important issues relating to biotic interactions across scales.

The centerpiece of the proposal is a 3600 ft2 glasshouse. This facility will consist of five compartments and a central
plant processing area. Above and beyond the typical environmental controls (light, temperature, humidity) each
compartment will combine a range of features necessary for addressing questions regarding biotic interactions such as
light quality (competition processes), flooding benches (differential stress tolerance), and CO2 control (alteration of
biotic interactions in the face of climate change). The plant growth infrastructure will be paired with field and lab
instrumentation necessary to carry out the corresponding large- and small-scale examinations of impact of these biotic
interactions on processes across scales. Supporting equipment for greenhouse studies that is required includes
equipment to quantify plant responses to stress such as plant imaging and image processing equipment, balances, and
laboratory equipment for tissue processing (tissue homogenizers, autoclave and centrifuge). Requirements for the field
infrastructure necessary for scaling up the controlled work conducted in the glasshouse include equipment for
quantifying biotic interactions (minirhizotrons; ground penetrating radar), abiotic factors (dataloggers for temperature,
humidity, water quality and quantity), and a vehicle for transportation among field sites and for transport of plant
material from field sites to the glasshouse facility for further investigation.

Benefits to Ontario include
1) Development of linkages with industry to address environmental issues relating to global change and increased
population growth;
2) Training of highly qualified personnel that will become the driving force behind the future economic success of
Ontario through innovation and knowledge translation;
3) Enhancement of Ontario’s position in the global knowledge-based arena.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


York University
Mr. Steven Mataija, Manager, Government Research Initiative Programs
Phone: (416) 736-2100 x 22507
E-Mail: smataija@yorku.ca

Lead Researcher(s): Laurence Harris,Michael Jenkin,Robert Allison
Full field vision and spatial orientation
How do humans know “which way is up” or “how much we have moved”? Answering these fundamental questions not
only provides insights into the foundations of human perception and visually-guided behaviour, but also provides
practical solutions to a diverse range of applications related to human performance in normal and unusual
environments. Such applications include human performance in outer space, the role of wide field-of-view displays in
enhancing the sensation of immersion in virtual environments, and understanding and treating disorientation-related
illnesses and deficits in older adult and clinical populations. This research will have wide application and benefits for
Ontarians by providing information that will inform policy with respect to a range of issues from the design of residences
for the elderly to the deployment of advanced driver aids on Ontario’s roads. The research will provide essential data
and perceptual models that will inform the development of advanced training technology, teleoperational systems, and
other display technology. It will also support interdisciplinary training for the next generation of highly qualified
personnel, contributing to Ontario’s growing knowledge economy.

One often overlooked sensory component in self-orientation and self-motion research is the effect of our wide visual
field, including the far periphery. Experimental apparatuses often fail to provide a wide-field visual stimulus and
teleoperational systems typically concentrate on task-related sensing. Yet the role of peripheral vision in controlling
posture and determining perceived orientation and motion is thought to be paramount. Furthermore, diseases
associated with age and their treatment (even the wearing of prescription glasses) often impact peripheral vision. This
project will develop and then use novel infrastructure to present controlled visual stimuli reaching out into the far
periphery to assess the contributions of peripheral vision to proprioceptive functions, specifically self-orientation and
self-motion perception. Research conducted within this project will investigate the role of the far periphery in isolation, in
conflict with other parts of the visual field, and as part of a coherent whole.

The requested funds will enable us to create full-field vision through three related custom-built installations. First, we
will build a cubic room eight feet on a side that can be placed in different orientations around a subject seated on a
chair that can itself be oriented about two axes relative to gravity. This room will be decorated with real objects to
provide high fidelity visual cues to the direction of up. The room module will be designed so that it can be removed to
provide an infinite walking surface on the inside of the roller to support experimental work in self-motion perception. A
second environment will be constructed to provide optic flow only (that is with no visual orientation cues) around the
subject. This Sphere Environment will be configured so that it can be rotated around an independently rotated subject.
Finally, we will build a very large screen computer driven display system that can present compelling three-dimensional
virtual environments over the entire field of regard.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


York University
Mr. Steven Mataija, Manager, Government Research Initiative Programs
Phone: (416) 736-2100 x 22507
E-Mail: smataija@yorku.ca

Lead Researcher(s): Demian Ifa
Mass Spectrometry-based tissue imaging: Improving diagnostics and heath care
This multi-institutional proposal brings together leading experts in the field of mass spectrometry (MS), pathology,
biochemistry, and cancer research to establish a unique consortium on imaging MS for the Canadian research
community. This consortium will be primarily focused on molecular profiling and imaging from thin sections of biological
tissues from several types of cancers including prostate, pancreatic and gastrointestinal malignancies. The presence of
specific molecules such as certain proteins or lipids in tissues can be used as an indicator of a disease state. These
molecules, called biomarkers, will be investigated using MS equipment and novel methodologies. This approach will
provide unprecedented details on cancer biomarkers in perfect alignment with standard techniques to assist clinicians
and pathologists in the diagnosis, prognosis of diseases and to select the most appropriate choice of treatment.

Imaging MS has become a powerful way to profile and characterize the spatial distribution of molecules in biological
tissues, in perfect alignment with histology and has been used to localize peptides and proteins through the direct
analysis of thin sections of fresh frozen tissues. This technique is distinctive by its capability to preserve the spatial
localization of diagnostic molecules – information that is typically lost when tissue extracts or homogenates are used.
Imaging MS has been used to study a wide range of biological systems. In particular, it has been used to determine the
abundance and distribution of compounds in numerous diseases, including cancer and neurologic disorders, and to find
biomarkers of disease from biopsy specimens. Subsets of biomarkers in tissues correlate well with disease diagnosis,
prognosis and response to therapy. Imaging MS can therefore be of enormous benefit to develop better diagnostics
through the analysis of biomarker distributions.

The proposed consortium aims to create a unique infrastructure in Canada and it will allow for Ontario research
community to be part of a network of researchers working on the forefront of the technology by linking biomarkers
analysis to patient care through imaging. The same biological sample can be analyzed in different nodes across the
country and the data compared and validated. This approach increases significantly the reliability in the results and
accelerates the discovery and standardization of biomarkers.

This proposal would allow the purchase of new equipment to set up laboratories specifically designed for state-of-the-
art imaging MS. One imaging system composed by a mass spectrometer, an automated matrix deposition device, a
microscope slide scanner, and a computer is requested for the York University node.

In addition, these new technologies and infrastructure have the potential to be applied to many important sectors for
Canada and generate important discoveries and impacts in forestry, environment, pharmaceutical research and many
others strategic biological systems.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


York University
Mr. Steven Mataija, Manager, Government Research Initiative Programs
Phone: (416) 736-2100 x 22507
E-Mail: smataija@yorku.ca

Lead Researcher(s): A. Kumarakrishnan
Ultrasensitive Measurements of Forces Using Laser-cooled Atoms
The accurate determination of the basic forces of nature is of the utmost scientific importance both for its impact on
fundamental research as well as for its significance in technological and commercial applications. Atoms cooled by
lasers constitute an intrinsically simple system that can be used as a sensitive probe of external forces. This proposal
seeks funding for infrastructure to support an experimental facility dedicated to utilizing cold atoms for ultrasensitive
measurements of a variety of basic forces. Specifically, the research program’s principal goal is to achieve high
precision measurements of electromagnetic and gravitational forces that govern the dynamics of cold atoms using
sophisticated tabletop experimental setups.

The cold atoms will be manipulated and controlled through the application of lasers and external electromagnetic fields.
Since the effects due to the different forces must be clearly separated, some variations on the basic experimental setup
are required, each targeting a different part of the problem. The infrastructure will support a range of precision
experiments measuring gravitational acceleration, gravity gradients, magnetic interactions, the atomic fine structure
constant, and atomic clock transitions. Prominent developments will include: a new generation of atomic clocks in
Canada that rely on rubidium atoms; new experiments in the field of Bose-Einstein condensation; construction of auto-
locking laser systems for gravimetric and LIDAR applications; and accurate techniques for calibrating commercial
gravimeters.

The main elements of the infrastructure include a variety of high power laser systems, sensitive instruments such as
gravimeters, magnetometers, frequency standards, microwave cavities, tilt sensors, seismometers, magnetic shields,
vacuum chambers and vacuum pumps and vibration isolation platforms. Experiments will also require optical detectors,
radio frequency and digital electronics, optoelectronics, optical elements, computer interfaces, software for data
analysis, low noise power supplies and specialized analog circuits.

The project carries with it significant prospects for economic impact through the fabrication and commercialization of
instruments related to gravimetric applications including oil and mineral exploration, and seismic monitoring. This
aspect of the research program will be pursued through an industrial partnership with an Ontario based company that is
the leading manufacturer of industrial gravimeters. Another significant benefit is the large number of highly qualified
personnel in the area of photonics who will be trained through this project. Photonics is one of the most dynamic
sectors of Ontario’s economy that has also traditionally benefited from applied laser physics. The collaborative nature of
the research program, including four research institutions, a national laboratory, and industry, ensures that the skills
and expertise acquired by personnel will be highly specialized in diverse areas. Applications will be related to the
development of a new time standard associated with the GPS network that can potentially impact provincial industry
related to photonics and play an important role in the pursuit of national and strategic goals. Additional impact will be
related to the development of LIDAR-based instrumentation that can impact the competitiveness of specialized
segments of industrial activity within Ontario that are linked to environmental monitoring and the national space
program.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


York University
Mr. Steven Mataija, Manager, Government Research Initiative Programs
Phone: (416) 736-2100 x 22507
E-Mail: smataija@yorku.ca

Lead Researcher(s): Michael Longford
Sensorium 3D: Institute for Stereoscopic 3D and Advanced Information Visualization
Significant industrial, scientific and government investments in state-of-the-art stereoscopic 3D (S3D) cinema and
media, 3D visualization and simulation, and flexible digital tools have set the stage for an historic shift in 3D visual
technologies. With this paradigm shift in our substantive capacity to manipulate and display large multi-dimensional
data sets in real-time, there is an urgent need to understand the cognitive impacts and the design potential of our
situated experience of these technologies. To address this need we will establish two complementary interdisciplinary
research centres under the umbrella, Sensorium 3D, bringing together researchers from the Fine Arts, Science and
Engineering, Education, and Health faculties. Co-located at York and OCAD Universities, the institute will serve as a
catalyst for building research capacity across disciplinary boundaries to answer questions such as: What new forms of
visualization, interface, and delivery are suitable for new 3D platforms? How does 3D imaging transform how we
navigate the world? How will these advanced 3D imaging systems change the ways we perceive, analyze, educate,
and represent the world around us in the 21st century?

Advances in 3D applications in the diverse areas of film, gaming, physical computing, architecture, data visualization,
augmented reality, and training all rely on:
1) advances in and application of a set of core technologies;
2) grammars, techniques, metaphors and conventions for their implementation and understanding; and
3) understanding of the underlying perceptual and cognitive processes supporting effective and/or appropriate use of
these technologies.
The proposed equipment builds a set of core technologies including 3D tracking and display systems for immersive
environments, 3D architectural projection, S3D cinema, 3D scanning, digital form-finding and rapid-prototyping. These
facilities will support the development of new grammars appropriate to emerging 3D platforms and delivery systems,
cutting across traditional disciplinary boundaries and building on new methods from art and design, science, and digital
media. In the Burton Auditorium at York, we will create a uniquely flexible, multi-modal and modular space that will
function as a theatre, gallery, laboratory, and a site for large-scale testing and prototyping—a platform for
interdisciplinary collaboration. No other facility currently exists in Ontario that enables comparative cross-platform
research in the area of 3D visualization. At OCAD, a visualization laboratory will be created consisting of a variety of
display environments and a collaborative cluster of mobile visualization design systems, providing researchers with the
capacity to develop rich graphic visualizations. Though physically separated, these facilities will not be isolated but will
be virtually linked so as to provide a unified virtual space for the exploration of 3D telepresence, collaborative
performance and mediated realities. These explorations will be grounded in research on how human perception,
cognition, interaction and health are affected or enhanced by these 3D systems and environments.

Sensorium 3D will benefit from and contribute to Ontario’s ongoing record of innovation in digital media and information
& communication technologies by enabling vital research in the ways we engage and interact with new 3D capture and
delivery systems, which are defining audio-visual media.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


York University
Mr. Steven Mataija, Manager, Government Research Initiative Programs
Phone: (416) 736-2100 x 22507
E-Mail: smataija@yorku.ca

Lead Researcher(s): James Whiteway
Airborne Laboratory for Planetary Science
   The proposal aims to advance the capacity at York University to build upon world leading research in planetary
science. This includes studies on earth as well as the exploration of other planets and asteroids. The basic model is
that advanced measurement techniques developed for earth-based research are applied for space exploration, and
vice-versa.

The main platform for the earth-based research will be an aircraft that will carry instruments for studies of atmospheric
pollution, Arctic sea ice, and climate change processes. Atmospheric measurement campaigns will focus on air
pollution that is generated within Ontario and by the oil sands industry. The aircraft will be equipped with instruments for
measurements of pollutants based on in situ sampling as well as laser remote sensing (LIDAR).

Aircraft flights above Hudson Bay and the Arctic Ocean will carry instruments to measure the thickness of sea ice.
Surveys over large areas will be vital for the assessment of the impact of climate change on the declining Arctic sea ice,
and to contribute key information for safe and efficient shipping and offshore operations. These flights will also include
equipment to measure the exchange of heat and humidity with the atmosphere in order to study the feedback between
changes in sea ice coverage, the atmosphere, and climate.

Research on planet Mars will follow from the accomplishments of the NASA Phoenix mission. Planetary exploration is
driven by assessment of habitability and water is the main factor. The LIDAR instrument on the Phoenix mission was
designed, constructed, and operated on Mars by the authors of this proposal. It was used to discover that it snows on
Mars, and this is an important factor in the hydrological cycle with exchange of water between the surface and
atmosphere. This proposal includes equipment for the development of instruments to measure atmospheric water
vapour for future missions to Mars. The new measurement techniques will also be applied for measurements of
atmospheric pollution on earth.

A LIDAR instrument for mapping the surface of an asteroid is being developed at York University for the NASA OSIRIS-
Rex mission. Testing and characterization will be carried out with equipment that is included in this proposal. The
prototype instrument will also be applied for the bathymetric measurement of melt pond depth in the sea ice studies.
Summary of Applications by Institution
This report provides a summary of information currently provided to MEDI concerning applications for large
infrastructure projects under the Ontario Research Fund - Research Infrastructure program.


York University
Mr. Steven Mataija, Manager, Government Research Initiative Programs
Phone: (416) 736-2100 x 22507
E-Mail: smataija@yorku.ca

Lead Researcher(s): Huaiping Zhu
Modeling Climate Change Impacts on Ecology of Vector-borne Diseases
We propose to build an Early Warning and Response System (EWARS) for vector-borne diseases. We have configured
a Decision Theater for this system, a visualization environment consisting of a four-sided room approximately 65 feet in
diameter with a 16-foot ceiling. On the main front wall (252 degrees of 360) will be rear-projection high-definition 10- by
8-foot display screens. Onto these screens are projected computer displays rendered in stereo, such that they appear
three-dimensional when viewed through polarized glasses (one image appears in one eye, the other, slightly offset
image is shown in the other). Soft swivel chairs with casters are positioned around the carpeted floor, and tables can be
brought in if the application warrants. Presentations in the Decision Theater are produced by the Departmental
Technical Support Team, visualization specialists and graphic designers. The Decision Theater will be “a learning and
decision space in which the latest understanding of complex social, economic, and natural processes and their
interactions are visualized.” Several features of the Decision Theater make it appealing for decision-making
applications, particularly concerning climate-change related to Vector-borne diseases, environmental and geographical
issues. As a virtual environment, the Decision Theater allows for the exploitation of depth cues in its three-dimensional
representations, including motion, immersion, and stereo vision. In addition, the size, set up, and furnishings of the
Decision Theater are designed for comfort and to facilitate interaction among participants. The potential of the Decision
Theater to engage decision makers, experts, and the broader public through dazzling and informative graphics that
literally surround them is considerable. Using a 260-degree rear projection comprising three screens and three
projectors that can display panoramic computer graphics or 3D screen video content, The Decision Theater creates a
truly immersive experience for its guests, which often include federal, provincial and municipal government, research
organizations and developers.

The York University Decision Theatre will be a world-class research facility for exploring and understanding the
mechanism of the spreading of vector-borne diseases in the context of a warming climate. Use of mathematical and
statistical modeling, the state-of-the-art visualisation, simulation and solutions tools, will enable decision-makers (such
as government officials, business leaders and policy makers) to address complicated issues in a dynamic, collaborative
and interactive environment. The Decision Theatre will be used to gather and present all relevant information and
visualise complex concepts for better-informed decision making. The proposed research will allow York University to
establish a state-of-the-art visualization system for Ontario. This facility will be unique in Ontario and the first of its kind
nationally, to use an integrated visualization approach for diseases prediction, control and prevention. York’s Decision
Theatre will focus on real-world issues relevant to today’s society and has the potential to serve as a global forum in
providing solutions to these issues.

				
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