Manuscript Writing 101: Essentials for Journal Acceptance

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					November 8, 2008
Early Career and FIT Program: Track A for the Basic Scientist
Scientific Sessions 2008
New Orleans

            Manuscript Writing 101:
        Essentials for Journal Acceptance

                                     Junichi Sadoshima
        Department of Cell Biology and Molecular Medicine,
         Cardiovascular Research Institute, UMDNJ, NJMS
                            Newark, NJ

                               DISCLOSURE INFORMATION
                                  Vasade Bioscience Inc.
                                         All papers co-authored by a No papers co-authored by a
Number of publications   15                    previous mentor            previous mentor

                                               Junior faculty position
     per year


                                                                                                     NIH funding
                          5                                                                          9/00 -present

                          0   86 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08

                               Pre-doc          Post-doc                  Independent Lab

                 Morisco C, Zebrowski DC, Vatner SF, Sadoshima J. The Akt-GSK3b pathway regulates
                       transcription of ANF induced by b adrenergic receptor stimulation in cardiac
                          myocytes. J. Biol. Chem.: 275, 14466-14475, 2000. (accepted in January)

• How can we successfully prepare
• How can we improve our productivity?
• Suitable Quality?

• Sufficient General Interest?

• Conclusions Justified?

• Clearly Written?

• Procedures Described?
• Clarify a central message before you
  start writing. Use PowerPoint
  presentations. Describe your work to a
  colleague in one or two sentences.
• A paper should address one main
• Irrelevant experimental data should be
• Write in your own voice.
• Eliminate the possibility of being
• Putting oneself in the reader’s position.

        Identify readers
        Keep to the word limit (Short papers are
              not equal to short manuscripts)
        Be consistent
        Present Figures and Tables clearly
        Avoid excessive abbreviations
        Use English editing services

Assist reviewers in understanding your work, and get constructive criticisms
     Assist readers in understanding your paper, and get more citations
• Seek opinions from non-experts. Find
  out which part of your manuscript is
  difficult to follow.
                 Circ Res
• Degree of Novelty (Excellent, Good,
  Satisfactory, Fair, Poor)
• Strength of Mechanistic Insights
• Technical Excellence
• Priority (Top 5%, Top 20%, Satisfactory, Fair,
• Recommendation (Accept, Reconsider after
  moderate revision, Reconsider after major
  revision, Reject)
  When should we submit?
• Manuscript with novel findings cannot
  be rejected easily.

      Mechanistic insights
• Find the underlying mechanism of the
  biological response.
• Study the functional significance of the
  biological response.
• Find the relevance of the biological response
  to pathophysiology.
• Study the properties of the endogenous
  molecule, using loss of function approaches.
• Study the in vivo significance of the biological
  response studied in vitro.
• Plan these experiments in the early stages
  of your study.
       How to increase your
• Assemble Figures and Tables in the early
  stages of your work.
• Prepare a folder for data and references.
• Start writing wherever you can. Write the
  paper in parts.
• Prepare outlines and headings and write the
  first sentence.
• Write quickly and put the draft aside for at
  least one day before revising
• Prepare for the revision in advance. Don’t be
  afraid of receiving criticisms.
• Always make a wish list for improvement.
       Manuscript Review
• The best opportunity to learn what is
  necessary for acceptance of the journal.
• It is not a waste of time. A good way to
  practice time management.
• The best exercise to improve the quality
  of your science.
• Making constructive comments benefits
  your experimental design as well.
    Meeting presentations
• The best opportunity to understand the
  quality of your data objectively.
• A good opportunity to make your wish
  list for future presentations.
• Always include new data.
• Accept criticism, assess the response of
  the audience, and improve the clarity of
  your presentation.
• Bring your manuscript to meetings.
         Yamamoto M, Yang G, Hong C, Liu J, Holle E, Yu X, Wagner T,
              Vatner SF, Sadoshima J. Inhibition of thioredoxin in the
            heart increases oxidative stress and cardiac hypertrophy. J
                         Clin Invest:112, 1395-1406, 2003.

                   2003 Microarray analyses, Bioinformatics

                         2004 AHA summer conference               Information regarding Mrj
                            Initial interest in DnaJb5                 (Dr. Molkentin)

                                                                                              Wish list-1
                                                                                          (to elucidate the
                        2005 AHA Scientific Sessions                                         mechanism
     The role of DnaJb5 in mediating the anti-hypertrophic actions of Trx1                by which Dnajb5
                                                                                        inhibits hypertrophy)
                                                                                  Wish list-2
              2006 AHA summer conferences, Scientific Sessions                (to elucidate the
               Trx1, TBP-2, DnaJb5, and HDAC4 form a complex                Cysteine modification
                                                                               of DnaJb5 and
                                                                           HDAC4, using proteomics)
                                                                                          Wish list-3
                         2007 AHA Scientific Sessions                            (to elucidate the Cysteine
          Trx1 regulates cysteine modification of DnaJb5 and HDAC4             modification or proteins in situ )
                                                Extensive proteomic analysis of proteins in situ

Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, Vatner SF, Sadoshima J. A redox
 dependent pathway for regulating class II HDAC and cardiac hypertrophy. Cell:
                                133, 978-993, 2008.
Bottomley, M. J. et al. J. Biol. Chem.
     283,26694-26704, 2008
          Sadoshima Lab
• Weekly report
• Submit abstracts to AHA Summer
  Conference and Scientific Sessions (a good
  indicator of the impact of your work)
• Abstract grading
• Critical reading at Journal Club
• Preparation of reviews, editorials, book
      Concluding remarks
• Nothing happens in one day. One
  publication helps your next publication.
  A publication could open up invaluable
• If your observation is really true, even
  very difficult criticisms can be
• Sadoshima Lab members
• Supports from NIH and AHA
• Dr. Stephen F Vatner

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