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					Quote ref: MHS/91124

Internal ref: LR/JE

                          THE UNIVERSITY OF MANCHESTER

                           PARTICULARS OF APPOINTMENT



                            PROJECT ASSISTANT (BADBIR)
                                 (Ref: MHS/91124)

1    The University invites applications for the above post which is tenable for a period of 12
     months in the first instance.

2    Salary will be within the range £15,216 – £18,027 per annum according to relevant
     experience. The University of Manchester will implement a new pay and grading
     structure in line with the national framework agreement, therefore all grades and
     salaries are currently under review and may change.

3    Informal enquiries may be made to Mrs Pat Creighton, Tel: 0161 275 1651, Email:

4    Applications should be returned by 21 September 2009 to:

                             Mrs Pat Creighton
                             ARC Epidemiology Unit
                             The University of Manchester
                             Rutherford house
                             Unit 4
                             40 Pencroft Way
                             Manchester Science Park
                             M15 6SZ

                             Email: pat.creighton@manchester.ac.uk

5    The University does not acknowledge applications or contact all unsuccessful
     applicants. If you have not been contacted within four weeks of the closing date you
     should assume that, on this occasion, your application has not been successful. We
     would, however, like to take this opportunity to thank you for your interest in The
     University of Manchester.

                            THE UNIVERSITY OF MANCHESTER


                                 ARC EPIDEMIOLOGY UNIT


                             PARTICULARS OF APPOINTMENT

                               BADBIR PROJECT ASSISTANT


The British Association of Dermatologists set up a Register to prospectively follow patients
with psoriasis who have started new biologic treatments. The aim of this register is to monitor
for possible serious adverse events, including important co-morbidity, malignancies, and
serious infections. This important national database is located at the arc Epidemiology Unit in
Manchester. It is proposed that the Register will monitor these events over at least a five-
year period with recruitment having started in October 2008 and to complete all follow-up by

Role of the Project Assistant

The project assistant who works on the register is the first point of contact for both health
professionals and patients and, therefore must always display a professional and efficient
manner. Awareness of good clinical practice (GCP) is essential to this role, particularly with
regard to data handling and record keeping and training will be provided where required. The
role requires initiative, sound judgement and the ability to relate to consultant dermatologists,
nurses and patients contacting the register, whilst fully respecting data confidentiality issues
at all times.

A good educational background is essential for this role as well as organisational skills,
excellent written and verbal communication skills and the demonstrable ability to multi-task.
In addition to this, experience of data entry (demonstrating both accuracy and an eye for
detail with a methodical and conscientious approach to work), experience of working with
complex computer databases (preferably experience of Microsoft Access), previous
experience of working with confidential data and familiarity with the 1998 Data Protection Act,
and the ability to work as part of a team are essential requisites.

Other desirable skills include previous experience of working on large-scale research studies
and the ability to meet tight deadlines.
List of responsibilities:

   •   Preparing Investigator Site Files prior to each set-up meeting.
   •   Preparing initial investigator baseline packs.
   •   Preparation of Site Specific Information forms for local Ethics and R&D submission.
   •   Collection of post from reception.
   •   Opening post, date stamping, prioritising and checking accuracy of data.
   •   Entering data into database.
   •   Mailing out questionnaires (including reminders for those not returned previously) to
       study participants and recording returns.
   •   Liaising with health professionals at participating dermatology centres across the UK
       (n=200+) who have registered patients, via phone, fax and email.
   •   Adding details of new dermatologists to the database as necessary.
   •   Generating and printing out reports for consultants showing details of patients
       registered and which stage of follow up they have reached.
   •   Performing some simple data quality checks.
   •   Generate simple recruitment reports.
   •   Filing of questionnaires.
   •   Ordering stationery in accordance with the budget and ensuring that supplies are
   •   Photocopying of documentation.
   •   Adding details of patients to a tracking database for budgetary payment purposes.
   •   Recording serious adverse event data using medical terms in a form ready for the
       drug safety assistants to report to the drug companies.
   •   Sending out appropriate letters, for example to request further essential clinical
       information from dermatology nurses/consultant dermatologists.
   •   Extracting relevant data from the database to answer specific queries from
       dermatologists, nurse specialists and patients.
   •   Speaking to patients on the telephone, which requires a sensitive manner and a full
       understanding of data confidentiality and familiarity with the 1998 Data Protection Act.
   •   Answering queries from patients, whilst bearing in mind the most important
       considerations of rights, safety and well-being of register participants.
   •   Using Powerpoint, Excel and Word to produce materials for oral presentations
   •   Helping the Register team in the organisation of dermatology nurses forums,
       European registries meetings, and other meetings.
   •   Attend dermatology meeting as required to promote the Register.
   •   Any other duties as required by the Register team.
Person Specification:


   •   A good educational background

   •   Previous experience of working with confidential data and familiarity with the 1998
       Data Protection Act.

   •   Awareness of good clinical practice

   •   Experience of data entry, demonstrating both accuracy and an eye for detail with a
       methodical and conscientious approach to work

   •   Experience working with computer databases (preferably experience of Microsoft

   •   Excellent written and verbal communication skills

   •   Good organisational skills

   •   Enjoy working as part of a team

   •   Demonstrable ability to multi-task


   •   Experience of working on large-scale research studies

   •   Ability to meet tight deadlines

Faculty of Medical and Human Sciences

The Faculty of Medical and Human Sciences comprising five Schools (Medicine; Dentistry;
Nursing, Midwifery and Social Work; Pharmacy and Pharmaceutical Sciences; Psychological
Sciences) is a major force within the University and one of the largest faculties of clinical and
health sciences in Europe. The Faculty boasts an annual research income that is almost half
that of the total research income of the institution and has strong interdisciplinary links with
other Schools and Faculties.

There are excellent new facilities across the broad range of our research including The
Wellcome Trust Clinical Research facility, The National Primary Care Research and
Development Centre, The Centre for Integrated Genomics in Medical Research, The North
West Genetics Knowledge Park, state of the art, research-only MRI scanners (1.5 and 3T)
and the Wolfson Molecular Imaging Centre (PET: both neuroPET and full-body scanners).
There are plans to further strengthen our key priority areas to deliver world-class multi-
disciplinary research with high impact in many areas including; Health Sciences,
Genetics/Genomics/Molecular Medicine, Pharmacy and Cancer Studies. The Faculty has a
student population comprising approximately 8,000 students registered for undergraduate
degree and diploma programmes and over 1,000 postgraduates on award-bearing
programmes. The Faculty shares research and teaching with the Faculty of Life Sciences
which provides some teaching for a wide range of its undergraduates.

School of Translational Medicine

The School of Translational Medicine is the largest of the four Research Schools in The
School of Medicine. Seven Research Groups (Clinical Neurosciences; Dermatological
Sciences; Epidemiology; Gastrointestinal Sciences; Genomic Epidemiology; Occupational
and Environmental Health; Respiratory Medicine) are bought together under the leadership
of Professor Chris Griffiths. The research interests of the groups range from basic science
through to applied and population based medicine across a range of clinical specialties.
Strong research links between these groups will ensure that the research carried out is truly

Epidemiology Research Group:

Research Group Leads: Professors Deborah Symmons and Jane Worthington This research
group is based at The University’s central campus and comprises of the arc Epidemiology
Unit (Professors Deborah Symmons and Jane Worthington), the Centre for Rehabilitation
Science (Professor Jackie Oldham) and the Cochrane Review Group (Professor Rajan

ARC Epidemiology Unit

Current research structure

The Unit is organised in three research divisions although a feature of the current
programme, that was particularly commended and encouraged by the recent Scientific
Advisory Board Meeting in January 2007, is the integration across research areas as projects
become increasingly multidisciplinary encompassing traditional epidemiological techniques,
health economics, genetic epidemiology and functional genomics.

Genetics and Genomics Division (Professor Jane Worthington)

A major research programme focused on the identification and characterisation of genetic
polymorphisms that influence susceptibility to and outcome of arthritic diseases. The group is
established as the national leader, with a strong international profile in genetic investigation
of rheumatoid arthritis (Jane Worthington, Anne Barton and Wendy Thomson). The benefits
of being based in an epidemiological environment are considerable with the establishment of
large well-characterised cohorts of cases underpinning high quality genetics studies. A
nationwide study of RA twins, a National Repository of RA affected sibling pair families, the
NOAR prospective study of inflammatory arthritis and the UK Biologics Register provide
unrivalled resources. Industrial collaborations (eg Astrazeneca and Affymetrix) have been
key in facilitating “state of the art” studies such as one of the first SNP-based whole genome
linkage studies. Jane Worthington is PI for RA, one of the seven diseases being investigated
by the Wellcome Trust Case Control Consortium. The group is also a major contributor to the
EU Autocure programme (JW principle investigator).
The group also has a national and international profile of research into the genetics of
juvenile arthritis (Wendy Thomson and Rachelle Donn), with the one of the worlds largest
cross-sectional collections of cases and the only prospective study of JIA (CAPS) being
based here. Through multiple collaborations the group is involved in further genetic
investigations of other arthritic conditions, in particular there a strong programme of research
into the genetic basis of psoriatic arthritis (Anne Barton). In addition the group has an
expanding pharmacogenetics programme (Anne Barton, WendyThomson). During the last
programme we have begun to establish a programme of functional genomics (Rachelle
Donn) focussed on steroid responsiveness, with a number of high calibre publications
already produced.

Clinical Studies Divisions (Professor Deborah Symmons)

These divisions comprise:

Inflammatory Musculoskeletal Conditions (IMC) Division (Dr Ian Bruce & Dr Kimme

Work in this division is focused on studying clinical cohorts of patients and identifying risk
factors for disease onset and outcome. This includes studies of the influence of treatment on
disease outcome using observational studies and clinical trials. The division includes a
pharmacoepidemiology group (Dr Kimme Hyrich) which comprises the British Society for
Rheumatology Biologics Register (the largest prospective observational study of the safety
and clinical effectiveness of biologic agents), and a number of large randomised controlled
clinical trials in IMC; a cardiovascular group (Dr Ian Bruce) which is studying the causes and
consequences of accelerated atherosclerosis in IMC; the Norfolk Arthritis Register (Professor
Deborah Symmons) which is the largest primary care derived cohort of early inflammatory
arthritis in adults; and the Childhood Arthritis Prospective study (Dr Wendy Thomson) which
is a large five centre prospective study of juvenile arthritis. The division also includes
outcome studies in SLE (Dr Ian Bruce) and scleroderma (Dr Ariane Herrick). There is also a
small health services research group which is carrying out work on evaluating the cost utility
of treatments and the provision of rheumatology manpower.

Non-Inflammatory Musculoskeletal Conditions Division (Dr Terry O’Neill & Dr John

The work of this division focuses on identifying risk factors for the onset and outcome of
common non-inflammatory musculoskeletal conditions. Many of the studies are conducted
using cohorts recruited from the general population. This division comprises the
musculoskeletal pain group (Dr John McBeth) which aims to identify the role of
psychological, genetic, constitutional (including hormonal) and environmental (including
mechanical) factors on the development of chronic musculoskeletal pain syndromes and
their persistence; and the osteoporosis group (Dr Terry O’Neill) which was initially based on
the European Prospective Osteoporosis Studies but now is focusing on osteoporosis in
males through the Unit’s joint leadership of European Male Aging Study and bone health in

Statistics and Information Division

There is a fourth division within the Unit which comprises the statistical and information
services necessary to underpin the research work. The division covers computer support,
database design and support, statistical support together with web site and information
services. The Unit has its own librarian and provides data on the occurrence and burden of
musculoskeletal conditions to a wide range of enquirers including the general public and the

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