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      INCREASED PLACENTAL VASCULARITY IN WOMEN WITH PRE-GESTATIONAL DIABETES USING 3D
                               POWER DOPPLER ANGIOGRAPHY
                                 1            2           1           1          1             1
                         N. Jones , N. Fenning , H. Mousa , E. Bradley , P. Clarke , G. Bugg
  1                                                                          2
      Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, Nottingham University, Nottingham,
                                                   United Kingdom
The signal intensity of the power Doppler information, Flow Index (FI), can be used as a measurement of vascularity
with in a 3D ultrasound volume of a placenta. This index is thought to be independent of the size of the volume. We
hypothesised that pre-gestational diabetes causes an increase in placental Flow index.
Method: Power Doppler ultrasound was applied and 3D ultrasound data sets of the placenta were obtained at 12
weeks, 16 weeks and 20 weeks in women with pre-gestational diabetes and women with otherwise uncomplicated
pregnancies. The FI was measured within the 3D volumes and comparisons were made between the two groups at
each gestation.
Results: At 12 weeks the mean FI (50.46; (SD) 4.82) of diabetic pregnancies (n=24) were significantly greater than
the mean FI of the controls (n= 20) (45.64; 4.68) (p< 0.001 ). This difference in FI was also seen at 16 weeks,
diabetic pregnancies ( n=19) (53.62; (SD) 3.34 ) versus controls (n= 26) (53.62; (SD) 3.34 ; p< 0.001 ) and 20 weeks,
diabetic pregnancies ( n= 16) (53.34; (SD) 3.04) versus controls (n=28) (48.40;(SD) 4.04; p= 0.002).
The mean placental volume at 12 weeks was greater in the diabetic group (p< 0.001). There was no difference in the
mean volumes at 16 weeks or 20 weeks between the two groups.
Conclusion: Histological examination of placenta shows that pre-gestational diabetes causes increased
angiogenesis and villous vascularity. Our study suggests that this increase in vascularity is already present in the
second trimester.

				
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posted:2/15/2012
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