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									Checkpoints in B cell Development:

B cell lineages
Kikuchi K, Kondo M. Developmental switch of mouse hematopoietic stem cells from fetal to adult type
occurs in bone marrow after birth. Proc Natl Acad Sci USA 103, 17852-17857, 2006.

Montecino-Rodriguez E, Leathers H, Dorshkind K. Identification of a B-1 B cell–specified progenitor. Nat
Immunol 7, 293-301 (2006).

Pre-B cell receptor
Kitamura D, Kudo A, Schaal S, et al. A critical role of lambda 5 protein in B cell development. Cell 69,
823, 1992.

Bankovich AJ,Raunser S, Juo ZS, et al. Structural insight into pre-B cell receptor function. Science 316,
291, 2007.
Immature B cell
Wardemann H, Yrasov S, Schaefer A, et al. Predominant autoantibody production by early human B cell
precursors. Science 5, 301 (2003)

Repertoire development
Ippolito GC, Schelonka RL, Zemlin M, et al. Forced usage of positively charged amino acids in
immunoglobulin CDR-H3 impairs B cell development and antibody production. J Exp Med 203, 1567,

Somatic Hypermutation and Class Switching
Nacionales DC, Weinstein JS, Yan X-J, et al. B cell proliferation, somatic hypermutation, class switch
recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus. J Immunol
182, 4226, 2009.

Long lived plasma cells
Luger EO, Fokuhl V, Wegmann M, et al. Induction of long-lived allergen-specific plasma cells by mucosal
allergen challenge. J Allergy Clin Immunol 124, 819, 2009.

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