UNIVERSITY COLLEGE LONDON Department of Pharmacology

UNIVERSITY COLLEGE LONDON Department of Pharmacology PHAR2002: General and Systematic Pharmacology (1 unit), 2008-2009 Course organiser: Dr. Talvinder S. Sihra A. PRE-REQUISITES FOR TAKING THE COURSE This lecture course is designed for students of pharmacology, physiology/pharmacology (joint honours) and medicinal chemistry. It will be assumed that students have an adequate background in mammalian physiology and biochemistry (e.g. PHOL1001, BIOC1001). B. AIMS: 1. To provide a sound knowledge of the actions of many of the important groups of drugs used in medicine. In particular, to emphasise, insofar as is known, the detailed mechanism of action of drugs at the molecular, cellular or tissue level, citing wherever possible experimental evidence. To show how drugs (and toxins) may be of use in elucidating physiological processes. To provide an understanding of how the time-course of drug action may depend on the processes of drug absorption, distribution, metabolism and excretion, and how changes in the concentrations of drugs in the body can be described quantitatively (pharmacokinetics). To show how the activity of a drug is related to its chemical structure and how structural changes can modify therapeutic efficacy or toxicity. To consider the problems of designing, developing and conducting clinical trials of new drugs. 2. 3. 4. 5. 6. C. OBJECTIVES On completion of the course, students will be able to give thorough written and brief verbal accounts of the following topics. 1. Receptor / transduction mechanisms. 2. Drug action in the peripheral nervous system (pns) and on tissues innervated by the pns. 3. Drug action in the cardiovascular, renal & respiratory systems. 4. Chemotherapy: drugs used in cancer & in viral, bacterial or fungal infection. 5. Drug action in inflammation; diabetes; the control of fertility. 6. Drug action on neurotransmission in the central nervous system (CNS). PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 1 7. Drugs in schizophrenia, Parkinson’s disease, epilepsy, anxiety, depression, general anaesthesia, analgesia and obesity. Drug dependence. 8. Design, & development of new drugs; relation of drug structure to pharmacological activity. Drug toxicity; clinical trials of new drugs. 9. The time course of drug action and the factors determining the plasma concentration-time relationships of clinically important drugs. 10. The solution of elementary problems in pharmacokinetics given the appropriate physicochemical, distribution and clearance data of example drugs. D. ABBREVIATED SYLLABUS General pharmacology: Drug targets. Mechanisms of drug action. Receptor structure, mechanisms and transduction processes. Pharmacokinetics. Structure-activity relationships. Development of new drugs and clinical trials. Drug toxicity. Systematic pharmacology: Peripheral nervous system, with emphasis on cholinergic and adrenergic mechanisms. Cardiovascular and renal pharmacology with specific consideration of drug use in hypertension, angina and dysrhythmias. Anticoagulants and lipid lowering drugs. Chemotherapy of infectious diseases and cancer. Mediators of inflammation, anti-inflammatory drugs and drugs affecting the immune response. Drug control of fertility and diabetes. Neuropharmacology, with specific consideration of drug use in Parkinson’s, schizophrenia, anxiety, depression and epilepsy. Analgesia and anaesthesia. Anti-obesity drugs. Drug dependence. E. TEACHING: Lectures run throughout terms 1 & 2. A comprehensive set of “handouts” will be provided. Students are expected to attend all lectures. Some (but not all) lecturers will also make their lecture slides available on the Course web page: (http://www.ucl.ac.uk/pharmacology/phar2002_b015/pharb015.html). Note however, that although these will indicate the important learning objectives, they will not in themselves provide sufficient information for a good examination performance. To ensure a good grade you will need to take notes from the lectures and to consult recommended textbooks (see later). It is estimated that students will need to spend 1-2 hours consolidating each lecture. There are computer-based exercises and suggested additional study associated with some of the lectures. Tutorials. Part of the “Coursework” requirements for this module includes compulsory attendance at ten tutorials. Each student will be assigned to a group (groups and venues will be arranged after enrolment) and will have a different tutor for each term. Students are expected to attend all tutorials. Attendance will be monitored and if this falls below 80%, students will be considered “Incomplete” for the module. This means that, whatever the performance with other coursework and the exam, students will have to re-enter the module the following year to attend the tutorials in full before being considered complete for the module. Student should therefore avoid missing any tutorials, and even in cases when this is unavoidable because of illness for instance, supporting documentation needs to be provided to the tutor confirming this. Coursework. Students are required to submit two essays, one from each section of the list (see later), which will be allocated after enrolment. In addition, there are some problem sheets PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 2 associated with the pharmacokinetics lectures. Deadlines are set for the submission of coursework. If you have sufficient grounds to request an extension to the deadline, you should complete the request form which can be obtained from the Departmental Teaching office or by download from the Department’s web site. Coursework record sheet: Students will be issued with a coursework record sheet and should ensure that this is signed by a member of staff when work is submitted. This will provide evidence, if needed, that they have indeed submitted coursework. The record sheet contains details of deadlines and penalties applied for late submission. Key skills taught &/or assumed. It is expected that students will be familiar with the College computer network and will be able to access and use any programs they are directed to by course tutors. It is also assumed that students have essay writing skills and can write coherently and legibly. (The assessment of essays will contain a component for presentation.) Recommended Textbooks: Pharmacology, 5th ed., 2003, Rang, Dale, Ritter & Moore Basic and Clinical Pharmacology, 9th ed., 2004, Katzung. Principles of Drug Action, 3rd ed., 1990, Pratt & Taylor. Goodman & Gilman's “The Pharmacological Basis of Therapeutics” 10th ed. 2001 Hardman et al. Pharmacology Condensed, 2004, Dale & Haylett (Revision aid) Lecturers may indicate additional, useful references. F. ASSESSMENTS: One essay from section A 5% One essay from section B 5% *Pharmacokinetics problems paper (50min) (3rd Dec) 10% In-course test (50min)(14th Jan.) 5% Final course examination (April/May) 75% (The exam will comprise MCQs, short answer and essay questions.) * Important: Please note that beginning 2008-2009, the Pharmacokinetics problems will be examined by an invigilated test on 3rd December. Students will be given all the potential test questions in the handouts of the first, second and third Pharmacokinetics lectures for practice. A selection of these (obviously with different numbers!) will be set in the test, which will be invigilated and timed for 50min. PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 3 Course Lecturers/Tutors: Staff e-mail Dr. D. Benton Dr. R. Burt Prof. A. H. Dickenson ACD Prof. A. C. Dolphin MF Dr. M. Farrant AJG Dr. A. J. Gibb AH Dr. A. Hobbs NSM Prof. N. S. Millar GWJM Dr. G.W.J. Moss JAP AGR DCHB RB AHD d.benton@ucl.ac.uk r.burt@ucl.ac.uk anthony.dickenson@ucl.ac.uk a.dolphin@ucl.ac.uk m.farrant@ucl.ac.uk a.gibb@ucl.ac.uk a.hobbs@ucl.ac.uk n.millar@ucl.ac.uk g.moss@ucl.ac.uk Lecturer (L) /Tutor (T) L L L L L L T T T T T T T T T T T T T T T (r) T T Dr. J. A. Pitcher julie.pitcher@ucl.ac.uk a.ramage@ucl.ac.uk Dr. A. G. Ramage t.sihra@ucl.ac.uk TSS Dr. T. S. Sihra l.sivilotti@ucl.ac.uk LGS Dr. L. G. Sivilotti SCS Dr. S.C. Stanford c.stanford@ucl.ac.uk m.stocker@ucl.ac.uk MS Dr. M. Stocker phil.thomas@ucl.ac.uk PT Dr. P. Thomas p.vergani@ucl.ac.uk PAV Dr. P. Vergani p.viard@ucl.ac.uk PV Dr. P. Viard dean.willis@ucl.ac.uk DW Dr. D. Willis From National Institute for Medical Research: tcarter@nimr.mrc.ac.uk TDC Dr. T. D. Carter L = Lecturer; T = Tutor; (r) Reserve Tutorial Groups A B C D E F G H I J Term 1 TSS GWJM LGS DW NSM JAP AGR RB DCHB AH L L L L L L L Tutors Term 2 AJG AHD SCS MF AGR PV PT TSS RB DCHB PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 4 ESSAYS (Essays will be allocated to each student by the course organiser at the start of the first term) Students must submit two essays, one from section A and one from section B. Students will be allocated the essays they have to do at the start of the course. The essay from section A must be submitted by 14th January (by 4.00pm), the first Wednesday of Term 2. The essay from section B must be submitted by 25th March (by 4.00pm), the last Wednesday of Term 2. For both submissions, a hardcopy and on-line submission to Turnitin is required. The staff member whose initials appear in brackets alongside each title may provide a lead reference or advice if necessary. Essays can include diagrams, tables etc. and may well benefit from headings. They should, however, retain a proper grammatical construction. (Guidance on essay writing is provided on the Department’s course web-site and on the UCL Key skills web pages: http://www.ucl.ac.uk/keyskills/resources/writlink.html). Each essay contributes 5% to the overall mark for the course. Essays should be approximately 1200 words long. (A modest over-run is permissible and penalties will be applied only for essays which exceed 1500 words at the rate of 1% per 100 words (or fraction of 100 words). Students must complete the essays specifically allocated to them. Submission of any other essays on the list will result in the work not being marked. Section A: Discuss the importance of HERG potassium channel pharmacology in relation to cardiotoxicity. 1. 2. 3. 4. Smooth muscle relaxation: An essential physiological necessity and important pharmacological target. Discuss. Describe the pathogenesis of atherosclerosis highlighting endothelial mediators and therapeutics that slow its progression. Describe the main characteristics of competitive antagonism and using suitable examples from either the adrenoceptor or histamine receptor fields, discuss how the development of selective antagonists has led to advances in therapeutics. Discuss the extent to which nicotinic acetylcholine receptors are considered important targets for drug therapy and drug discovery. Is gene or drug therapy more likely to produce an effective treatment for cystic fibrosis? Discuss the potential of heterotrimeric and monomeric G proteins as drug targets. Discuss the mechanisms by which drugs can interfere with transmission at the sympathetic neuroeffector junction. Discuss the mechanisms by which drugs may lower blood pressure by acting within the CNS. How may drugs modify micturition. Non-adrenergic-non-cholinergic transmitters in the autonomic nervous system. (DCHB) (RB) (AH) (AJG) 5. 6. 7. 8. 9. 10. 11. (NSM) (GWJM) (JAP) (AGR) (AGR) (AGR) (LGS) Section B: 12. Pharmacological importance of ATP binding cassette (ABC) multidrug transporters for drug bioavailability and tissue distribution. 13. The roles of sodium channels in pain messages. 14. Long term changes in the activity of neurones in the brain - implications for health and disease. 15. Compare and contrast the mechanism(s) of action of currently used general anaesthetics with that of ethanol. 16. Describe the mechanisms of action of the newer antiepileptic drugs, lamotrigine and tiagabine. 17. The Sonic Hedgehog-GLI pathway as a target for prostate cancer chemotherapy. 18. Outline the different forms of phosphodiesterase (PDE). Describe the consequences of PDE inhibition and suggest how these may be of therapeutic benefit. 19. "MRSA" refers to bacterial pathogens resistant to a particular class of bactericidal antibiotic. Discuss the mechanism of action of this group of antibiotics and the nature and development of resistance. What alternative bactericidal antibiotics, with different mechanisms of action, might be useful with MRSA? 20. Risk and benefits of post-menopausal hormone replacement therapy: a critical assessment of the evidence. 21. Discuss the pharmacology of amphetamines, focusing especially on methamphetamine and damphetamine. 22. Monoamine transporters as a target for drug action. 23. Write an essay on recent developments in drug therapies that modify the actions of peptides in the brain. 24. Why is NF-kappa B a therapeutic target for cancer? 25. Discuss the advantages and disadvantages in using antibodies to treat human disease. (PAV) (AHD) (AHD) (ACD) (MF) (GWJM) (TSS) (TSS) (LGS) (SCS) (SCS) (SCS) (DW) (DW) PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 5 Department of Pharmacology PHAR2002: General and systematic Pharmacology 2008/2009 Lectures/Tutorials are on Mondays at 11.00 a.m. and selected Wednesdays at 10.00 a.m. and on Fridays at 11.00 a.m. Lectures will be held in the AV Hill Lecture Theatre unless indicated otherwise. TERM 1 Sep 26 Fri Introduction. Drug targets, selective toxicity, therapeutic index. TSS Sep 29 Mon Receptor structure. NSM Oct 1 Wed Basic principles of pharmacokinetics. Drug absorption. MS Note: Lecture will be in the Darwin Lecture Theatre Oct 3 Fri Transduction mechanisms. TDC Oct 6 Mon The peripheral nervous system. AHD Oct 8 Wed Tutorial (1) TSS, GWJM, LGS, DW, NSM, JAP, AGR, RB, DCHB, AH Oct 10 Fri Dose-response curves. Affinity and efficacy. AJG Oct 13 Mon Drug antagonism. AJG Oct 15 Wed Drug distribution. MS Note: Lecture will be in the Darwin Lecture Theatre Oct 17 Fri Cholinergic pharmacology I. LGS Oct 20 Mon Cholinergic pharmacology II. LGS Oct 22 Wed Tutorial (2) TSS, GWJM, LGS, DW, NSM, JAP, AGR, RB, DCHB, AH Oct 24 Fri Adrenergic pharmacology I. SCS Oct 27 Mon Adrenergic pharmacology II. SCS Oct 29 Wed Drug excretion. MS Note: Lecture will be in the Darwin Lecture Theatre Oct 31 Fri Smooth muscle pharmacology. TDC Nov 3 Mon Local anaesthetics. Antidysrhythmic drugs. MF Nov 5 Wed Tutorial (3) TSS, GWJM, LGS, DW, NSM, JAP, AGR, RB, DCHB, AH Nov 7 Fri Antianginal drugs. Cardiac glycosides. AGR Nov 10 Mon Diuretics. AGR Nov 12 Wed The metabolism of drugs. MS Note: Lecture will be in the Darwin Lecture Theatre Nov 14 Fri Antihypertensive drugs. AGR Nov 17 Mon Atherosclerosis and lipid lowering drugs. AH Nov 19 Wed Kinetics of drug absorption and elimination. MS Note: Lecture will be in Bentham House (Bentham MLT) Nov 21 Fri Histamine and other mediators of inflammation. DW Nov 24 Mon Anticoagulants. Fibrinolytics SCS Nov 26 Wed Tutorial (4) TSS, GWJM, LGS, DW, NSM, JAP, AGR, RB, DCHB, AH Nov 28 Fri Antihistamines. Treatment of peptic ulcers. DW Dec 1 Mon Eicosanoids. DW Dec 3 Wed Pharmacokinetics Test TSS Note: Test will be held in Bentham House (Bentham MLT) Dec 5 Fri Anti-inflammatory drugs. DW Dec 8 Mon Drugs used to treat asthma. DW Dec 10 Wed Tutorial (5) TSS, GWJM, LGS, DW, NSM, JAP, AGR, RB, DCHB, AH Dec 12 Fri Free End of term I PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 6 TERM 2 Jan 12 Jan 14 Mon Wed Free TEST Note: Test will be held in Bedford Way G03 (26, Bedford Way) Pharmacological control of fertility. Insulin and oral antidiabetic agents. Clinical trials. Note: Lecture will be in Bedford Way G03 (26, Bedford Way) Chemotherapy: anti-bacterial drugs, I. Chemotherapy: anti-bacterial drugs II, anti-fungal drugs. Tutorial (6) AJG, AHD, SCS, MF, AGR, PV, PT, TSS, RB, DCHB (Test follow-up) Chemotherapy: anti-viral drugs Chemotherapy: anti-cancer drugs. Free Introduction to neuropharmacology. Aminoacid neurotransmitters. Benzodiazepines. Tutorial (7) AJG, AHD, SCS, MF, AGR, PV, PT, TSS, RB, DCHB Parkinson’s disease and other motor disorders. Schizophrenia. Anti-emetics. Free Anxiolytics. Drugs used in affective disorders. Tutorial (8) AJG, AHD, SCS, MF, AGR, PV, PT, TSS, RB, DCHB Anti-epileptics. Analgesics. Free General anaesthetics. Mechanism of action of ethanol. Non-medical use of drugs, dependence. Tutorial (9) AJG, AHD, SCS, MF, AGR, PV, PT, TSS, RB, DCHB Anti-obesity drugs. Drug toxicity. Free Relationship between chemical structure and pharmacological activity. Free Tutorial (10) AJG, AHD, SCS, MF, AGR, PV, PT, TSS, RB, DCHB End of Lectures Revision Workshop 1 – General Pharmacology and Autonomic Revision Workshop 2 – Inflammation and Chemotherapy Revision Workshop 3 – Neuropharmacology TSS Jan 16 Jan 19 Jan 21 Jan 23 Jan 26 Jan 28 Jan 30 Feb 2 Feb 4 Feb 6 Feb 9 Feb 11 Feb 13 Feb 16 Feb 18 Feb 20 Feb 23 Feb 25 Feb 27 Mar 2 Mar 4 Mar 6 Mar 9 Mar 11 Mar 13 Mar 16 Mar 18 Mar 20 Mar 23 Mar 25 May 1 May 1 May 1 Fri Mon Wed Fri Mon Wed Fri Mon Wed Fri Mon Wed Fri Mon Wed Fri Mon Wed Fri Mon Wed Fri Mon Wed Fri Mon Wed Fri Mon Wed Fri 12.00 Fri 14.00 Fri 16.00 PAV TSS AHD TSS TSS DW DW AHD MF AHD SCS SCS SCS MF AHD ACD SCS SCS TSS TSS TSS AJG DW TSS PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 7 Pharmacology PHAR2002 and PHAR2005 Tutorial Groups Numbers indicate essays allocated to you for term 1 and 2 respectively. TUTORIAL GROUPS A Term 1 - TSS Term 2 - AJG ADAMS-MOGAJI ADISA AKANOVA ALAM AMAN AMAR ASHRAF BARUCH BEEBEEJAUN BUDNIK CAO CHAN COLLINS CONSTANTINOU CROSBY CRUISE THAKUR USHAKOV WANIGARATNE Mojeed Theodora Assiya Rafeah Yahyah Ruth Azhaar Ahmad Neta Bat-el Mohammad Kazim Sabina Yu Lai Hing Catherine Sophie Marie James Anthony Thomas David Divya Kathy Dinusha Chathurangi B Term 1 - GWJM Term 2 - AHD 2 3 1 5 2 5 2 1 6 1 7 2 1 2 5 5 6 8 7 15 16 25 19 14 19 15 12 20 12 22 15 25 14 19 19 20 24 23 DALGLEISH DAURENBEKOV A DEHGHANITAFTI ECONOMIDES GAMAGE GORDON GUNATUNGA HARVEY HEADLEY HER HOLLOWAY HUGHES HUGHES IONESCU JOLLY JOSHI Nicole Zhaniya Ebrahim Marcos William Rashmi Vasundhara Matthew Robert Nadika Tom Sarah Charles-henry Maximilian Joshua Sam William Michael Anne Marie Komal Sanjay C Term 1 - LGS Term 2 - SCS 1 1 1 4 1 7 3 6 1 1 3 5 7 7 3 1 4 25 25 17 12 23 17 20 12 25 16 19 24 24 16 12 17 KANDAWASVIKA KEASBERRY KHATRI KROL KU KUO LALY LAM LAM LAU LAU LAU LEE LEE LI LI Michael T Vanessa Nicolle Hetal Karolina Anna Chih Hung Jih Sen Masoud Phu Minh Man Hin Jade Yan Shin Dawn Hay Wun Sophia Pik Ka Yin Ho Kar Yan Patrizia Chun-yiu Sucillna 4 4 2 1 3 5 7 4 10 3 4 5 1 6 4 11 17 18 14 13 17 19 24 17 25 16 18 19 13 21 17 25 CONTINUED PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 8 Pharmacology PHAR2002 and PHAR2005 Tutorial Groups Numbers indicate essays allocated to you for term 1 and 2 respectively. TUTORIAL GROUPS D Term 1 - DW Term 2 - MF LIM LING MA NAGINGO NEVIES NWANKPA NWUBA OKYERE BOAKYE OSMAN PANAGUITON PATEL QURESHI RIAZ SALIM SETH SHIN Kian Lung Derek Kelvin Wai Kit Chris Kudra Neil Ugonna Chinyelum Emmanuel Janina Jon Isaac Keenal Mohammed Omar Usama Saba Saira Mrinal Yongwha E Term 1 - NSM Term 2 - AGR 2 2 3 1 7 2 3 8 8 8 3 9 7 1 4 5 15 15 16 12 24 15 16 24 24 24 17 25 24 13 17 19 SHRAGER SMITH SMITH SNELL SONG TEBBS-WARNER TILLO TOWNSON TRAN TSE VASAVAN VELURAJAH SHRAGER Edward Alex Brett Churchill Catherine Daniel Mark James Joseph Thomas Miguel Louisa Trang Minh Iris Tharnitha Arunganesh Edward F Term 1 - JAP Term 2 - PV 1 5 7 7 9 3 9 4 2 4 5 6 1 12 19 22 22 25 16 24 18 15 17 19 21 12 AGBAKOBA ANDERSON ASLAM BABATUNDE BADRU BALKIN BELESSIOTIS BEOKU-BETTS BISHAR ABDIRAHMAN BOURGINE BOZNAKOVA BUTT CARTER CASSIDY CHAN CHO CHO Ify Rosie Samihah Erika Oluwakemi Ayinke Rukayat Joshua Nathan Katherine Phoebe Candace Faiza Barbara Maria Faisal Lucas Lisa Louise Claire Louise Eva Yi Fung Tsz fan Tsz fong 5 1 5 1 3 2 1 4 10 11 7 6 3 6 3 1 1 16 12 16 12 14 13 12 15 22 12 20 16 14 16 15 12 12 CONTINUED PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 9 Pharmacology PHAR2002 and PHAR2005 Tutorial Groups Numbers indicate essays allocated to you for term 1 and 2 respectively. TUTORIAL GROUPS G Term 1 - AGR Term 2 - PT CHUN CLOSTRE CORDIER CRITCHLEY DAGLESS DEMETRIOU DEO EAGLE FAHY FARAM FERNANDO FIDDIAN FINCH FLETCHER GAIFULINA GAMI GEE FARGEN LEIGH Hyein Nourane Laura Fenton Kate Selina Louise Amanda Shuchita Zara Khadija Vivienne Liam Kate Helen Mariyanu Hettige Thimira Guy Nicola Jane Thomas Riana Priya Davina Michelle Benjamin Priscilla H Term 1 - RB Term 2 - TSS 6 5 4 4 9 9 2 2 4 5 5 3 7 1 7 6 1 8 8 18 16 15 15 21 21 13 15 15 16 16 14 18 12 20 16 13 18 18 GILANI GRIMME GUINARD HASSAN HIGO HOUDMONT HSU HYDER JANES JEYARAJAH JIN JOEL KEIGHTLEY KHAN KOHLI LATHAM LAU IYER Mehwish Ashley-james Charlotte Mohammed Badrul Tolani Marie Shu-wen Judith Usman Robert Jasmine Janany Yunhee Zelah Christopher Mark Shabana Pashmina Kaur Jonathan Tina Shreyas Mahadeva I Term 1 - DCHB Term 2 - RB 7 2 1 2 11 3 3 11 2 8 3 1 6 2 1 4 11 8 20 13 12 12 23 14 14 23 12 20 15 12 18 12 12 15 23 18 LEUNG LIM LIU LORT LOZANOWILHELMI LU LUI MEHTA MIRZA NAZIR NDUWAYO NICHOLAS NORBERT PALIPANE PALMERBROWN PATEL PATEL PHOON WOLFES Siu Tim Chrissie Su Run William Michael Edward Marta Mengyan Beverly Pankti Rabiah Hassan Ali Natasha Leo Alexander Anne Tharmini Natasha Guy Nikki Priyesh Yuan Anne Christine 3 1 2 1 4 5 7 7 5 5 7 1 7 2 4 5 8 4 8 14 22 13 12 15 16 20 18 16 21 18 22 18 13 18 16 21 15 18 CONTINUED PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 10 Pharmacology PHAR2002 and PHAR2005 Tutorial Groups Numbers indicate essays allocated to you for term 1 and 2 respectively. TUTORIAL GROUPS J Term 1 - AH Term 2 - DCHB PROBERT RICHARDSHAMILTON ROMAINE SAVLANI SHALAGANOVA SIDDEEK SOLANKI SORRENTINO TAHIR TURNER VASANTHAKUMA R VUONG WAN WESTACOTT WONG YOGARATNAM YOUNG ZARRINDEJ Lucy Harriet Lucy Alex Karishma Aiman Omar Sanoos Mohamed Shyam Alessandra Sophia Natalie Jesika Lynda Ka Yan Thomas George Alexander Kylie Amy Leanne Kianoush 3 4 9 5 6 9 7 5 4 8 3 4 7 11 11 3 2 2 15 15 21 16 22 21 18 16 15 20 16 15 20 23 22 14 13 13 PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 11 TUTORIAL VENUES TUTORS Tutorial 2 22nd Oct. 2008 Term 1 Tutorial 4 26th Nov. 2008 Tutorial 5 10th Dec. 2008 Tutorial 7 11th Feb. 2009 Tutorial 6 28th Jan. 2009 Term 2 Tutorial 9 11th Mar. 2009 Tutorial 10 25th Mar. 2009 Tutorial 8 25th Feb. 2009 A B TSS GWJM AJG AHD Cruciform Foyer Seminar Room 2 Rockefeller Room 339 Malet Place Eng 1.13 Tutorial 3 5th Nov. 2008 Tutorial 1 8th Oct. 2008 GROUPS Term 1 Term 2 Rockefeller Room G14 Rockefeller Room G15 C D E F G LGS DW NSM JAP AGR SCS MF AGR PV PT H I RB DCHB TSS RB J AH DCHB Rockefeller B14 Rockefeller B15 Gordon Square (16-18) G06 Drayton B19 Medical Science Anatomy B15 Roberts 110 RockeSouth Wing Committee Malet Medical Sciences Pharmacology feller 333 Room Place Seminar Room G40 Eng 1.13 Tottenham Ct Rd (188) SB4 Pearson G23 NE entrance Drayton House B05 Physiology Drayton Tottenha Physiology South Seminar B05 m Ct Rd Seminar Wing Room 249 SB4 Room 249 Council Room Medical Sciences Pharmacology Seminar Room G40 Drayton Edgeworth Gustave Cruciform Cruciform Room Tuck LT LT 2 Foyer Seminar room 1 PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 12 Venues: Tutorial Groups: Locations Tutorial rooms – Term 1 Cruciform Foyer Seminar Room 2 Rockefeller Room 339 Rockefeller B14 Rockefeller B15 Gordon Square (16-18) G06 Drayton B19 Roberts 110 Rockefeller 333 South Wing Committee Room Tottenham Ct Rd (188) SB4 Pearson G23 NE entrance Drayton House B05 Medical Sciences Pharmacology Seminar Room G40 Tutorial Groups A (Tutorial 1-5) B (Tutorial 1-5) C (Tutorial 1-5) D (Tutorial 1-5) E (Tutorial 1-5) F (Tutorial 1-5) G (Tutorials 1-3) G (Tutorial 4) G (Tutorial 5) H (Tutorials 1-4) H (Tutorial 5) I (Tutorial 1-5) J (Tutorial 1-5) Tutorial rooms – Term 2 Rockefeller Room G14 Malet Place Eng 1.13 Rockefeller Room G15 Rockefeller B14 Rockefeller B15 Gordon Square (16-18) G06 Medical Science Anatomy B15 South Wing Committee Room Malet Place Eng 1.13 Medical Sciences Pharmacology Seminar Room G40 Pearson G23 NE entrance Physiology Seminar Room 249 Drayton B05 Tottenham Ct Rd SB4 Physiology Seminar Room 249 South Wing Council Room Drayton Edgeworth Room Gustave Tuck LT Cruciform LT 2 Cruciform Foyer Seminar room 1 Tutorial Groups A B (Tutorial 6) B (Tutorials 7-10) C (Tutorials 6-10) D (Tutorials 6-10) E (Tutorials 6-10) F (Tutorials 6-10) G (Tutorial 6) G (Tutorials 7) G (Tutorials 8-10) H (Tutorials 6-10) I (Tutorials 6) I (Tutorials 7) I (Tutorials 8) I (Tutorials 9) I (Tutorials 10) J (Tutorials 6-7) J (Tutorials 8) J (Tutorials 9) J (Tutorials 10) PHAR2002_B15-08-09_w_notes_f.doc (22/10/2008) 13