CV Montero UM format revised 1 09

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					                                                            A. J. Montero - Curriculum Vitae - 1
                                                                        Updated 1/06/09

                                CURRICULUM VITAE


       Name               Alberto José Montero
       Date of Birth             October 11, 1971
       Current position          Assistant Professor of Medicine

       Current work address      University of Miami
                                 Sylvester Comprehensive Cancer Center
                                 1550 NW 10th Avenue
                                 Fox Building #305
                                 Miami, FL 33136

       Languages          Spanish and English
       Citizenship        U.S.


August, 1990 – December, 1995    Bachelor of Arts
                                 Major, Philosophy and Psychology
                                 University of Texas
                                 Austin, TX

May, 1995 – May, 1999            Doctor of Medicine
                                 University of Texas Medical Branch
                                        Galveston, TX

June, 1999 – June, 2002          Internal Medicine Residency
                                 Physician Scientist Pathway
                                 University of Texas Health Science Center
                                 Houston, TX

June, 2002 – June, 2005          Hematology-Oncology Fellowship
                                 University of Texas M. D. Anderson Cancer Center
                                 Houston, TX

Present Position

July, 2008-Present               Assistant Professor of Medicine
                                 Division of Hematology-Oncology
                                                                  A. J. Montero - Curriculum Vitae - 2
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                                     University of Miami, Miller School of Medicine

Specialty/Board Certification:

       2002                   Internal Medicine

       2005                   Hematology/Oncology


       2002-2005              Texas
       2005-2009              South Carolina
       May, 2008-Present      Florida


July, 2005 – July, 2008       Assistant Professor of Medicine
                              Division of Hematology-Oncology
                              Medical University of South Carolina
                              Charleston, SC

Other Appointments
January, 2006-July, 2008      Associate Fellowship Director for Hematology/Oncology


Peer Reviewed Journal Articles:
Crump WJ, Tessen RJ, and Montero AJ. “The department without walls. Acceptability, cost,
and utilization of interactive video technology.” Archives of Family Medicine. 6(3): 273-8,
May-June 1997.

Montero AJ, Díaz-Montero CM, Malpica A, and Kavanagh JK. Langerhans cell histiocytosis
of the female genital tract: a literature review. International Journal of Gynecologic Cancer 13:
1-8, 2003.

Deng Wu-Guo, Zhu Ying, Montero A, and Wu KK. Quantitative Analysis of Binding of
Transcription Factor Complex to Biotinylated DNA Probe By a Streptavadin-Agarose Pulldown
Assay. Analytical Biochemistry. 2003 Dec 1;323(1):12-8.
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Montero AJ, Fossella F, Valero V, and Hortobagyi G. Docetaxel in Solid Tumors: A
Systematic Review of the Clinical Data. Lancet Oncology. 2005 Apr;6(4):229-39.

Montero AJ, Rouzier R, Lluch A, Buzdar A, et al. Long-Term Survival Benefit of
Anthracycline- Based Adjuvant Chemotherapy in Breast Cancer Patients with Ten or More
Metastatic Axillary Lymph Nodes: a Multi-Institutional Retrospective Study. Cancer. 2005 Jul

Montero AJ, Esparza-Guerra L, Murray J, Rosales M, et al. Phase I Study of Dose-Dense
Docetaxel and Doxorubicin Every 14 Days with or without GM-CSF in Patients Metastatic
Breast Cancer. Drugs R D. 2005;6(5):299-305.

Montero AJ, McCarthy JJ, Chen G, Rice L. Acute Respiratory Distress Syndrome After
Rituximab Infusion. Int J Hematol. 2005 Nov;82(4):324-6.

Hayslip J, Montero A. Tumor suppressor gene methylation in follicular lymphoma: a
comprehensive review. Mol Cancer. 2006 Oct 6;5:44.

Montero AJ, Estrov Z, Freireich EJ, Khouri IF, Koller CA, and Kurzrock R. Phase II Study of
Low-Dose Interleukin-11 in Patients with Myelodysplastic Syndrome. Leuk Lymphoma. 2006

Montero AJ, Diaz-Montero CM, Mao L,Youssef EM, Estecio M, Shen L, and Issa JP.
Epigenetic Inactivation of EGFR by CpG Island Hypermethylation in Cancer. Cancer Biol Ther.
2006 Nov;5(11):1494-501. Epub 2006 Nov 19.

Skorupa A, Beldner M, Kraft A, Montero AJ. Fatal Rhabdomyolysis as a complication of Et-
743 (Yondelis) Chemotherapy for Sarcoma: Case Report and Literature Review. Cancer Biol
Ther. 2007 Apr 24;6(7) [Epub ahead of print].

Deng WG, Montero AJ, Wu, KK. Interferon-γ suppresses cyclooxygenase-2 promoter activity
by inhibiting C-Jun and C/EBPβ binding. Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1752-
9. Epub 2007 Jun 7.

Diaz-Montero CM, El Naggar S, El Naggar R, Al Khami A, Montero AJ, Cole DJ, Salem ML.
Priming of naive cells in the presence of IL-12 selectively enhances the survival of
CD8+CD62Lhi cells and results in superior anti-tumor activity Cancer Immunol Immunother.
2008 Apr;57(4):563-72. Epub 2007 Aug 28.

Beldner MA, Green MR, Meyer M, Shannon S, Kraft AS, Sherman C, Montero AJ. Phase I
dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with
recurrent lung cancer. BMC Cancer. 2007 Dec 20;7(1):231.

Hayslip J, Chaudhary U, Green MR, Meyer M, Dunder S, Sherman S, Salzer S, Kraft A,
Montero AJ. Bortezomib in combination with celecoxib in patients with advanced solid tumors:
a phase I trial. BMC Cancer. 2007 Dec 3;7(1):221.
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Gudena V, Verma N, Post G, Kizziah M, Fenning R, Montero AJ. Metastatic Chest Wall
Malignant Peripheral Nerve Sheath Tumor Responding to Sorafenib: Case Report and Literature
Review. Cancer Biol Ther. 2008 Mar 19;7(6) [Epub ahead of print]

Marcela Diaz-Montero C, Salem ML, Garrett-Mayer E, Cole DJ, Montero AJ. Increased Levels
of Circulating Myeloid-Derived Suppressor Cells in Solid Tumor Patients Correlate With
Advanced Clinical Cancer Stage, Increased Tumor Burden, and Cyclophosphamide Containing
Chemotherapy. Cancer Immunol Immunother. 2008 Apr 30. [Epub ahead of print]

Jiang Y, Kimchi ET, Montero AJ, Staveley-O'Carroll KF, Ajani JA. Upper gastrointestinal
tumors: current status and future perspectives. Expert Rev Anticancer Ther. 2008 Jun;8(6):975-

Salem ML, Diaz-Montero C, Alkhami, A, Montero AJ, Cole DJ Recovery from
cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which
can mediate enhanced prime-boost vaccination anti-tumor responses in vivo when stimulated
with the TLR3 agonist poly(I:C). J Immunol. (Manuscript Accepted).

Invited Articles:
Montero AJ, Valero Vicente. Treatment of a Patient with Locally Advanced Breast Cancer
Treated with Epirubicin-Containing Primary Chemotherapy. Case Studies in Breast Cancer.
June 2003.

Montero A, Hortobagyi G. The Evolving Role of Taxanes in the Management of Early Stage
And Locally Advanced Breast Cancer. Oncology Exchange. 2004 April: Vol 3 (Suppl 1): 5s-7s.

Zhu Y, Montero AJ, Cornett WR. Genomics in breast cancer; what the surgeon must know.
Contemporary Surgery. 2007 May: Vol 63, Issue 5: 299-304.

Jiang Y, Montero AJ, and Staveley-O’Carroll KF. Adjuvant and Preoperative Therapy for
Localized Gastric Cancer. Gastrointestinal Cancer Research: Vol 1, Issue 4.

Milling DL, Montero AJ, Jiang Y, Gastrointestinal Stromal Tumors: Review of Molecular
Biology and Clinical Implications. Gastrointestinal Cancer Research (Manuscript Accepted).

Book Chapters:
Montero AJ, Varadhachary G, and Abbruzzese, JL. Unknown Primary Cancer: Diagnosis and
Management. Medical Oncology: A Comprehensive Review. 3rd Edition.

Submitted Manuscripts
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Montero AJ, Diaz-Montero CM, Liu, J, McIntyre BW, Logothetis C, Tannir N. Decreases in
IL-6 and IL-8 in Serum of Patients with Metastatic Renal Cell Carcinoma Treated with
Interferon Alpha-2b are Strong Independent Predictors of Clinical Benefit.

Seminar Invitations
Breast Cancer Update: Looking Back At 2005. Department of Internal Medicine Grand Rounds,
January 2006 Medical University of South Carolina

Breast Cancer Update 2007. South Carolina Medical Association Annual Meeting. May 5, 2007

Medical Issues in Cancer Patients: The Important Role of Primary Care Physicians. South
Carolina Medical Association Annual Meeting. May 5, 2007

Presentations At National Meetings
Montero AJ, Shen L, Valero V, and Issa JP. CHFR methylation as a marker of taxane
sensitivity in breast cancer. Poster presentation. American Society of Clinical Oncology Annual
Meeting. New Orleans, LA. June 4-8, 2004.

Montero AJ, Rouzier R, Lluch-Hernandez A, Kau SW, et al. Long-term survival benefit of
anthracycline-containing adjuvant chemotherapy in breast cancer patients with ten or more
positive lymph nodes: a multi-institutional retrospective study. Poster presentation. 27th Annual
San Antonio Breast Cancer Symposium. December 8-11, 2004.

Montero AJ, Diaz-Montero CM, Mao L, Youssef EM, et al. Epigenetic Inactivation of EGFR-1
by Aberrant Promoter Methylation: Implications for Combining Hypomethylating Drugs and
EGFR Inhibitors. Poster Presentation. American Association of Cancer Research meeting
Anaheim, CA 2005.

Montero AJ, Diaz-Montero CM, Wang X, McIntyre BW, Tannir N. Predictive Utility of Serum
Cytokine Levels in Patients with Metastatic Renal Cell Carcinoma (MRCC) Treated with
Interferon Alfa (IFNa). Poster presentation. American Society of Clinical Oncology Annual
Meeting. Atlanta, GA 2006.

Beldner MA, Sherman CA, Meyer M, Green MR, Shannon S, Montero AJ, Kraft AS. A Phase I
Study of Weekly Topotecan and Vinorelbine in Recurrent Lung Cancer. Abstract. American
Society of Clinical Oncology Annual Meeting. Atlanta, GA 2006.

Dunder S, Chaudhary U, Green M, Meyer M, Brescia F, Kraft A, Salzer S, Montero AJ. A
Phase I trial of bortezomib and celecoxib in patients with advanced solid tumors. Abstract.
American Society of Clinical Oncology Annual Meeting. Atlanta, GA 2006.

N. K. Ibrahim, G. Nguyen, D. Suki, B. Hennessy, A. Montero, J. E. Sarriera, F. Symmans, V.
Valero, R. Sawaya, K. Aldape. Clinicopathological correlation (CC) and outcome of breast
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cancer patients (pts) with resected brain metastasis (BM). Poster Presentation. American Society
of Clinical Oncology Annual Meeting. Atlanta, GA 2006.

M. Mitas, A. Graham, A. Khoors, Y. Chen, D. Lewin, P. Davoodi, K. Mikhitarian, A. Montero,
D. Cole, M. Wallace. The Ets transcription factor Esx regulates expression of metastasis-
associated genes in non-small cell lung cancer (NSCLC). Poster Presentation. American Society
of Clinical Oncology Annual Meeting. Atlanta, GA 2006.

A AlKhami, AJ Montero , M Salem, K Vissage, DJ Cole, Marcela Diaz-Montero. Circulating
Levels of CD4+ CD25+ T cells Correlate with Clinical Cancer Stage And Inversely Correlate with
CD8+ T cells. Poster Presentation. American Association of Immunologists Annual Meeting.
Miami, FL 2007.

AJ Montero , M Salem, K Vissage, A AlKhami, DJ Cole, Marcela Diaz-Montero. Circulating
Immature Myeloid Cells (ImC) Levels Correlate with Clinical Cancer Stage and
Cyclophosphamide (CTX) Treatment. Poster Presentation. American Association of
Immunologists Annual Meeting. Miami, FL 2007.

J Brashears, A J Brisendine, U B Chaudhary, N F Esnaola, A J Montero, DT Marshall.
Preliminary Results of a Phase II Study of Induction Gemcitabine/Oxaliplatin (GEMOX) and
Cetuximab Followed by Surgery or Concurrent Intensity Modulated Radiation Therapy (IMRT)
and Capecitabine for Locally Advanced Pancreatic Cancer. Poster Presentation. Radiological
Society North America Annual Meeting. Chicago, IL 2007.

U. B. Chaudhary, V. Gudena, D. L. Milling, P. O'Brien, A. J. Montero, J. Brashears, D.
Marshall, B. Hoffman, E. Garrett-Mayer, N. Esnaola. Preliminary results of a Phase II
neoadjuvant trial with gemcitabine/oxaliplatin and cetuximab followed by surgery or concurrent
intensity modulated radiation therapy (IMRT) with capecitabine for patients with borderline
resectable and unresectable nonmetastatic pancreatic cancer. Poster Presentation. American
Society of Clinical Oncology. Gastrointestinal Cancers Symposium. Orlando, FL 2008.

Montero AJ, Dewaay DJ, Salem M, Cole DJ, Diaz-Montero CM. Circulating immature myeloid
cells in breast cancer patients correlate with clinical cancer stage and cyclophosphamide
treatment: implications for cancer immunotherapy. Poster Discussion. San Antonio Breast
Cancer Symposium. San Antonio, TX 2007.


Extramural and Intramural Grants
       2008           Urbieta Colon Cancer Foundation Grant ($48,000)

       2006-2007      Research Centers for Minority Aging Research (RCMAR) Scholar
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       2005-2006     American cancer Society Institutional Research Grant ($19,500)
       2005-2006     Chain Reaction for a Cure Foundation ($20,000)
       2004-2006     NIH Clinical Research Loan Repayment Program Grant ($55,000)

Current Clinical Protocols as Principal Investigator

Investigator Initiated Studies
Phase II Study of Neoadjuvant Treatment with NOV-002 in Combination with Doxorubicin and
Cyclophosphamide Followed by Docetaxel in Patients with Stages IIB-IIIC Breast Cancer
(CTO#101072/Novelos; 1/07 $205,325 direct/total; IND 76,582).

Myeloid Suppressor Cells in Breast Cancer (CTO#100953/Chain reaction for a Cure; $20,000

Phase I/II Study of BZL-101 and Weekly Gemcitabine in Patients With Metastatic Pancreatic
Adenocarcinoma or Locally Unresectable or Metastatic Biliary Tract Cancers (Pending IND

Peripheral Blood Molecular Staging of Breast Cancer: A Prospective Cohort Study Designed to
Determine the Clinical Significance of Molecular Detection of Breast Cancer in the Peripheral
Blood of Stage IV Breast Cancer Patients (CTO#101039/Sponsor: WI Gillanders Washington

Industry Sponsored Studies
A Phase I Study to Evaluate the Safety/Tolerability and Immunogenecity of V-930 in Patients
with Cancers Expressing CEA and/or HER-2 (CTO#100973/Merck).

Phase I/II, Open-Label, Dose Escalation Study to Assess the Safety, Tolerability, and
Pharmacokinetics of INCB007839 Following Multiple Oral Doses in Patients with Solid Tumors
(CTO#100872/Incyte Corporation).

An Open-Label Study of Capecitabine and Docetaxel as Neoadjuvant Treatment for Patients with
Recently Diagnosed HER2-neu Negative Breast Cancer Plus Trastuzumab for HER2-neu
Positive Breast Cancer (CTO #100921/Roche).

A Phase III Randomized, Controlled Trial of Myocet, Trastuzumab and Paclitaxel versus
Trastuzumab and Paclitaxel for First Line Therapy of Metastatic Breast Cancer
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A Phase I Study to Evaluate the Safety/Tolerability and Immunogenicity of V930/V932 in
Patients with Cancers Expressing HER-2 and/or CEA (CTO#10184/Merck)

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase III Study in Patients with
Advanced Carcinoid Tumor Receiving Sandostatin LAR and RAD001 10mg/d or Sandostatin
LAR and Placebo (CTO#101071/Novartis)

A Phase I/II Clinical Trial Assessing Safety and Efficacy of BZLl0l for Metastatic Breast Cancer
(CTO# 101105/Bionovo).

A Randomized Phase 2 Study of the Ant-Angiogenesis Agent AG013736 in Combination with
Chemotherapy and Bevacizumab in Patients with Metastatic Colorectal Cancer Preceded by a
Phase 1 Portion (CTO#100992/Pfizer)

Cooperative Group Trials
A Randomized Phase III Trial of Exemestane versus Anastrozole in Postmenopausal Women
with Receptor Positive Primary Breast Cancer” (CTO# 101014/MA. 27).

Phase III Randomized Trial of Anastrozole Vs Anastrozole and Fulvestrant as First Line Therapy
for Post Menopausal Women with Metastatic Breast Cancer (CTO#100991/SWOG S0226).

A Phase III Trial Evaluating the Role of Exemestane Plus GnRH Analogue as Adjuvant Therapy
for Premenopausal Women with Endocrine Responsive Breast Cancer (CTO# 101012/ IBCSG-

A Double-blind, Randomized, Placebo-Controlled Phase III Trial of Carboplatin, Paclitaxel and
BAY 43-9006 versus Carboplatin, Paclitaxel and Placebo in Patients with Unresectable Locally
Advanced or Stage IV Melanoma (CTO# 101082/ECOG 2603).

Completed Investigator Initiated Studies
Circulating Tumor Cells in Metastatic Hormone Receptor Positive Breast Cancer (CTO#

Phase I Trial of Bortezomib (VELCADETM) and Celecoxib in Patients with Advanced Solid
Tumors (CTO# 100825/ Millennium).

Phase I Study of Topotecan in Combination with Vinorelbine in Recurrent Lung Cancer (CTO

Editorial Responsibilities
2005-Present The American Journal of Medical Sciences
2005-Present Drugs RD
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2006-Present Southern Medical Journal

Professional/scientific societies:

2002-Present           American Society of Clinical Oncology
2003-Present           American Association of Cancer Research
2006-Present           Member of Breast Cancer Committee Southwest Oncology Group (SWOG)

Honors and Awards:

       2005            American Cancer Society Institutional Research Grant Award

       2004            ASCO/AACR Methods in Clinical Cancer Research Workshop Travel

       2004            School of Breast Oncology Course Travel Award

       1998            Division of Pathology Tropical Medicine Research Award.

       1998            McLaughlin Medical Student Fellow

       1997-1995       Dean’s List

       1994            UT-Austin Summa cum laude (high honors).

       1994            Golden Key National Honor Society

       7/06-7/08     Hematology/Oncology Lecturer for 3rd year medical student internal
medicine rotation (Medical University of South Carolina)


Medical University of South Carolina
      Hollings Cancer Center Committees
             2005-2008       Experimental Therapeutics Committee
             2005-2008       Protocol Review Committee
             2005-2008       Breast Cancer Multidisciplinary Committee
             2005-2008       GI Cancer Research Committee
             2007-2008       Cancer Control Committee

University of Miami
       July-2008 to Present    Sylvester Cancer Center Phase I Committee
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                            Breast Cancer Site Disease Group Member
                            Hepatobiliary Cancers Site Disease Group Member
Community Activities
2006-Present South Carolina Hispanic Health Initiative Advisory Board

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