2010/2011 — III YEAR STUDENT DOCTORS — PATHOPHYSIOLOGY PROGRAM
1. Introductory seminar 04–08 X 2010
Introduction to pathophysiology
2. The cell and genetic material 11–15 X 2010
Why study cells?
Cell composition and cell complexity
Organelles
The cytoskeleton
Cell-cell interactions
The cell cycle and the control of the cell cycle
DNA, RNA and ribozymes
Biosynthesis, structure, nomenclature and function of proteins
3. Stem cell-based therapy.
Basic molecular techniques used for study of gene expression 18–22 X 2010
Classification and subpopulations of stem cells (SCs)
Circulation of SCs in human
Cell therapy
Flow Cytometry and it's practical application
Gene and protein therapy — current status and future prospects
Delivering DNA into cells — transfections
Gene's blocking — Antisense oligomers strategy
4. Pathophisiology of protein metabolism 25–29 X 2010
Introduction to metabolism of amino-acids and proteins
Disorders of digestion and absorption
Inborn errors of amino-acids metabolism
Enzymopathies
Genetically determined defects of biosynthesis of cellular, secretion and serum proteins.
5. Pathophysiology of carbohydrate metabolism 02–05 XI 2010
Metabolism of carbohydrates — an introduction
Disorders of digestion and absorption
Enzymopathies
Diabetes mellitus (epidemiology, classification, etiology, molecular basis of pathogenesis, complications,
impaired glucose tolerance, glycosylated proteins and their role in diagnosis and disease monitoring, prevention).
6. Pathophysiology of lipid metabolism 08–12 XI 2010
An introduction to lipids metabolism
Disorders of digestion and absorption
Dyslipidaemias — classification, etiology, pathogenesis
Obesity
Atherosclerosis — etiology, pathogenesis, complications, risk factors, prevention
7. Summary and crediting of seminars (2–6) 15–19 XI 2010
8. TEST I (seminars 2–6) 27 XI 2010
9. Inflammation 29 XI–03 XII 2010
Inflammation as an universal response of the organism to injury
Cellular events of inflammation:
- Organs, tissues, cells and humoral factors involved in inflammation process
Inflammation triggering factors:
- infectious
- chemical
- physical
Types of immunological reactions in inflammation
- cellular
- humoral
Different mechanisms involved in inflammation:
- the role of cytokines
- the role of adhesion molecules
Local and systemic symptoms of inflammation
Acute phase proteins and their role in disease diagnosis
Specific and non-specific inflammation
Chronic inflammation — etiology and pathogenesis
Connective tissue — structure and functions in inflammation
Repairing mechanisms — wound’s healing
10. Immunopathology 06–10 XII 2010
Immunopathology — definition
Immunodeficiency syndromes:
- phagocytic
- humoral (lymphocytes B)
- cellular (lymphocytes T)
- mixed
- complement associated
- Chronic and recurrent infections
- Neoplastic diseases — the role of immunologic system in pathogenesis of neoplasia
Pathologies associated with immunologic system dysfunction:
- Hypersensitive reactions — type I–IV according to Gell and Coombs
- Autoimmunologic disorders
11. Neoplasia I 13–17 XII 2010
Introduction to neoplasia — definition, classification and epidemiology
Molecular basis of carcinogenesis: protooncogenes, oncogenes and tumor suppressor genes, telomers and
apoptosis
The biology of neoplastic progression: cell cycle (cyklins, DNA ploidy, mitotic index), angiogenesis, the
molecular mechanisms of metastasis
12. Neoplasia II 03–07 I 2011
Cancerogenes and risk factors
Neoplasia and systemic defence
Paraneoplastic syndromes,
„Grading” and „Staging”.
Ways of curing cancer
- Conventional methods of cancer therapy
- Gene therapy of neoplasia — current status and future perspectives.
Molecular diagnosis of neoplasia.
Prevention of cancer
13. Summary and crediting of seminars (9–13) 10–14 I 2011
14. TEST II (seminars 9–13) 15 I 2011