Benedict

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					                               Christian Benedict, PhD in human biology
                             Department of Neuroscience, Uppsala University
                                        Box 593, s-751 24 Uppsala
                               Phone: 0046-18-471-4136, Fax: +46 18 511540

    PERSONAL INFORMATION

                        Born on the 11.12.1976 in Hamburg, Germany, married, 5 children


    EDUCATION

2008                    PhD in human biology (summa cum laude), University of Lübeck, Germany

2003                    Diploma (equivalent to M.Sc.), Nutrition Science, University of Kiel, Germany


    PROFESSIONAL APPOINTMENTS

2009- present           Postdoctoral research fellow, Dept. of Neuroscience, University Uppsala, Sweden (awarded by the
                        Swedish Research Council)
                                                                         &
                        Principal investigator in the German Collaborative Research Center”Plasticity and Sleep”

2003-09                 Research Scientist, Institute for Neuroendocrinology (Prof. Born), University of Lübeck, Germany

    HONORS AND AWARDS

2011                    Dr. Werner-Fekl-Prize from the German Association for Nutritional Medicine

2011                    Young Researcher Grant from the Dept. of Neuroscience, Uppsala University

2009                    Professor-Otto-Roth-award for the best dissertation at the Medical University of Lübeck, Germany

2006                    Silvia-King-Award from the German Diabetes Association, Germany


    POSITIONS OFFERED

2011                    Offer from the University of Aachen for a W1 Professorship entitled “Functional
                        Neuroimaging of the Chemosensory System” at the Dept. of Diagnostic and Interventional
                        Neuroradiology

    AD-HOC REVIEWER

                        Annals of Internal Medicine, Diabetes, American Journal of Clinical Nutrition, Brain & Behavior &
                        Immunology, Obesity, Neurobiology of Aging, Chemical Senses, Biological Psychology, Expert
                        opinion on Pharmacotherapy

    FUNDING (COMPETETIVE, AS PRINCIPLE INVESTIGATOR)

                        Postdoctoral Fellow Grant, Swedish Research Council, 1440000 SEK; Tore Nilsons Foundation for
                        Medical Research, 110000 SEK, Sweden; Åke Wibergs Foundation, 150000 SEK, Sweden; Ingrid
                        Thurings Stiftelse for Medical Research, 40000 SEK, Sweden; Novo Nordisk Foundation, 300000
                        DK, Denmark; German Research Council, 176900 €


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       PUBLICATIONS

2012                  Schiöth HB, Craft S, Brooks SJ, Frey II WH, Benedict C. Brain insulin signaling and Alzheimer`s disease: Current evidence
                      and future directions. Mol Neurobiol, invited review.

2011                  Benedict C, Shostak A, Lange T, Brooks SJ, Schiöth HB, Schultes B, Born J, Oster H, Hallschmid M. Diurnal rhythm of
                      circulating nicotinamide phosphoribosyltransferase (Nampt/visfatin/PBEF): impact of sleep loss and relation to glucose
                      metabolism. J Clin Endocrinol Metab., accepted

                      Benedict C, Jacobsson JM, Rönnemaa E, Almén MS, Brooks SJ, Schultes B, Fredriksson R, Lannfelt L, Kilander L, Schiöth
                      HB. The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men. Neurobiol
                      Aging. 2011; 32(6):1159.e1-5.

                      Benedict C, Hallschmid M, Lassen A, Mahnke C, Schiöth HB, Born J, Lange T. Acute sleep deprivation reduces energy
                      expenditure in healthy men. Am J Clin Nutr. 2011;93(6):1229-36.

                      Benedict C, Brede S, Schiöth HB, Lehnert HL, Schultes B, Born J, Hallschmid M. Intranasal insulin enhances postprandial
                      thermogenesis and lowers postprandial serum insulin levels in healthy men. Diabetes. 2011; 60(1):114-8.

                      Benedict C, Frey II WH, Schiöth HB, Schultes B, Born J, Hallschmid M. Intranasal insulin as a therapeutic option in the
                      treatment of cognitive impairments. Exp Gerontol, Feb-Mar;46(2-3):112-5.

                      Brooks SJ, Savov V, Allzén E, Benedict C, Fredriksson R, Schiöth HB. Exposure to subliminal arousing stimuli induces
                      robust activation in the amygdala, hippocampus, anterior cingulate, insular cortex and primary visual cortex: A systematic
                      meta-analysis of fMRI studies. NeuroImage, accepted.

                      Ott V, Benedict C, Schultes B, Born J, Hallschmid M. Intranasal administration of insulin to the brain impacts cognitive
                      function and peripheral metabolism. Diabetes Obes Metab, accepted.

                      Jacobsson JA, Almén MS, Benedict C, Hedberg LA, Michaëlsson K, Brooks S, Kullberg J, Axelsson T, Johansson L,
                      Ahlström H, Fredriksson R, Lind L, Schiöth HB. Detailed analysis of variants in FTO in association with body composition
                      in a cohort of 70-year-olds suggests a weakened effect among elderly. PLoS One. 2011;6(5):e20158.

                      Brooks SJ, Barker GJ, O'Daly OG, Brammer M, Williams SCR, Benedict C, Schiöth HB, Treasure JK, Campbell IC.
                      Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study. BMC
                      Psychiatry, accepted.


2010                  Krug R, Benedict C, Born J, Hallschmid M. Comparable sensitivity of postmenopausal and young women to the effects of
                      intranasal insulin on food intake and working memory. J Clin Endocrinol Metab., 2010; 95(12):E468-72.

2009                  Schmid SM, Hallschmid M, Jauch-Chara K, Wilms B, Benedict C, Lehnert H, Born J, Schultes B. Short-term sleep loss
                      decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory
                      conditions in healthy men. Am J Clin Nutr. 2009: 90(6):1476-82.

                      Benedict C, Scheller J, Rose-John S, Born J, Marshall L. Enhancing Influence of Intranasal Interleukin-6 on Slow Wave
                      Activity and Memory Consolidation during Sleep. FASEB J. 2009:23(10):3629-36.

                      Dimitrov S, Benedict C, Heutling D, Westermann J, Born J, Lange T. Cortisol and epinephrine control opposing circadian
                      rhythms in T cell subsets. Blood. 2009:113(21):5134-43.

                      Benedict C, Kern W, Schmid SM, Schultes B, Born J, Hallschmid M. Early morning rise in hypothalamic-pituitary-adrenal
                      activity: a role for maintaining the brain's energy balance. Psychoneuroendocrinology, 2009: 34(3):455-62.

2008                  Hallschmid M, Benedict C, Schultes B, Perras B, Fehm HL, Kern W, Born J. Towards the therapeutic use of intranasal
                      neuropeptide administration in metabolic and cognitive disorders. Regul Pept. 2008 :149(1-3):79-83.

                      Benedict C, Kern W, Schultes B, Born J, Hallschmid M. Differential sensitivity of men and women to anorexigenic and
                      memory improving effects of intranasal insulin. J Clin Endocrinol Metab. 2008: 93(4):1339-44.

                      Hallschmid M, Benedict C, Born J, Kern W. Targeting metabolic and cognitive pathways of the CNS by intranasal insulin
                      administration. Expert Opin Drug Deliv. 2007: 4(4):319-22.

                      Hallschmid M, Benedict C, Schultes B, Born J, Kern W. Obese men respond to cognitive but not to catabolic brain insulin
                      signaling. Int J Obes (Lond). 2008: 32(2):275-82.

2007                  Benedict C, Hallschmid M, Schultes B, Born J, Kern W. Minireview: Intranasal insulin to improve memory in humans.
                      Neuroendocrinology, 2007: 86(2):136-42.




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       Benedict C, Dimitrov S, Marshall L, Born J. Sleep enhances serum interleukin-7 concentrations in humans. Brain Behav
       Immun. 2007: 21(8):1058-62.

       Benedict C, Ghio AJ, Gehring H, Schultes B, Peters A, Oltmanns KM. Transient hypoxia and downregulation of circulating
       prohepcidin concentrations in healthy young men. Haematologica. 2007: 92: 125-126.

       Benedict C, Hallschmid M, Schmitz K, Schultes B, Ratter F, Fehm HL, Born J, Kern W. Intranasal Insulin Improves
       Memory in Humans: Superiority of Insulin Aspart. Neuropsychopharmacology 2007: 32(1):239-43.

2006   Kern W, Benedict C, Schultes B, Plohr F, Moser A, Born J, Fehm HL, Hallschmid M. Low cerebrospinal fluid insulin levels
       in obese humans. Diabetologia. 2006: 49(11):2790-2.

       Dimitrov S, Lange T, Benedict C, Nowell MA, Jones SA, Scheller J, Rose-John S, Born J. Sleep enhances IL-6 trans-
       signaling in humans. FASEB J. 2006: 20(12):2174-6.

       Schultes B, Peters A, Hallschmid M, Benedict C, Merl V, Oltmanns KM, Born J, Fehm HL, Kern W. Modulation of food
       intake by glucose in patients with type 2 diabetes. Diabetes Care. 2006: 28(12):2884-9.

2005   Benedict C, Dodt C, Hallschmid M, Lepiorz M, Fehm HL, Born J, Kern W. Immediate but not long-term intranasal
       administration of insulin raises blood pressure in human beings. Metabolism. 2005: 54(10):1356-61.

       Benedict C, Hallschmid M, Scheibner J, Niemeyer D, Schultes B, Merl V, Fehm HL, Born J, Kern W. Gut protein uptake
       and mechanisms of meal-induced cortisol release. J Clin Endocrinol Metab. 2005: 90(3):1692-6.

2004   Hallschmid M, Benedict C, Schultes B, Fehm HL, Born J, Kern W. Intranasal insulin reduces body fat in men but not in
       women. Diabetes. 2004: 53(11):3024-9.

       Hallschmid M, Benedict C, Born J, Fehm HL, Kern W. Manipulating central nervous mechanisms of food intake and body
       weight regulation by intranasal administration of neuropeptides in man. Physiol Behav. 2004: 83(1):55-64.

       Benedict C, Hallschmid M, Hatke A, Schultes B, Fehm HL, Born J, Kern W. Intranasal insulin improves memory in
       humans. Psychoneuroendocrinology. 2004: 29(10):1326-34.




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