From Wikipedia, the free encyclopedia RANK
RANK
Tumor necrosis factor receptor superfamily, member 11a,
NFKB activator
Interactions
RANK has been shown to interact with TRAF6,[4][5][6][7][8]
Identifiers
TRAF5,[5][6][7] TRAF1,[7][8] TRAF2[5][6][7][8] and
Symbols TNFRSF11A; CD265; FEO; LOH18CR1; ODFR; OFE; TRAF3.[7][8]
OPTB7; OSTS; PDB2; RANK; TRANCER
External
IDs
OMIM: 603499 MGI: 1314891 HomoloGene: 2848
GeneCards: TNFRSF11A Gene
See also
• RANKL
RNA expression pattern • Osteoimmunology
References
[1] Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie
MT, Martin TJ (1999). "Modulation of osteoclast
differentiation and function by the new members
of the tumor necrosis factor receptor and ligand
families". Endocr. Rev. 20 (3): 345–57. doi:10.1210/
er.20.3.345. PMID 10368775.
More reference expression data [2] Wong BR, Josien R, Choi Y (1999). "TRANCE is a TNF
family member that regulates dendritic cell and
Orthologs osteoclast function". J. Leukoc. Biol. 65 (6): 715–24.
Species Human Mouse PMID 10380891. http://www.jleukbio.org/cgi/
content/abstract/65/6/715.
Entrez 8792 21934
[3] Theill LE, Boyle WJ, Penninger JM (2002). "RANK-L
Ensembl ENSG00000141655 ENSMUSG00000026321 and RANK: T cells, bone loss, and mammalian
20:
evolution". Annu. Rev. Immunol. 20 795–823.
UniProt Q9Y6Q6 O35305
doi:10.1146/annurev.immunol.20.100301.064753.
RefSeq NM_003839.2 NM_009399.3 PMID 11861618.
(mRNA) [4] Mizukami, Junko; Takaesu Giichi, Akatsuka
RefSeq NP_003830.1 NP_033425.3 Hiroyuki, Sakurai Hiroaki, Ninomiya-Tsuji Jun,
(protein) Matsumoto Kunihiro, Sakurai Naoki (Feb. 2002).
"Receptor activator of NF-kappaB ligand (RANKL)
Location Chr 18: Chr 1:
(UCSC) 59.99 – 60.05 Mb 107.68 – 107.74 Mb activates TAK1 mitogen-activated protein kinase
kinase kinase through a signaling complex
PubMed [1] [2] containing RANK, TAB2, and TRAF6". Mol. Cell. Biol.
search
(United States) 22 (4): 992–1000. doi:10.1128/
MCB.22.4.992-1000.2002. ISSN 0270-7306.
RANK),
Receptor Activator of Nuclear Factor κ B (RANK also
PMC 134634. PMID 11809792.
known as TRANCE Receptor, is a type I membrane pro-
http://www.pubmedcentral.nih.gov/
tein that is expressed on the surface of osteoclasts and is
articlerender.fcgi?tool=pmcentrez&artid=134634.
involved in their activation upon ligand binding. RANK is
[5] ^ Darnay, B G; Haridas V, Ni J, Moore P A, Aggarwal
also expressed on dendritic cells and facilitates immune
B B (Aug. 1998). "Characterization of the
signaling.
intracellular domain of receptor activator of NF-
RANKL (Receptor Activator for Nuclear Factor κ B Li-
kappaB (RANK). Interaction with tumor necrosis
gand) is found on the surface of stromal cells, osteoblasts,
factor receptor-associated factors and activation of
and T cells. [1] [2] [3]
NF-kappab and c-Jun N-terminal kinase". J. Biol.
Chem. (UNITED STATES) 273 (32): 20551–5.
doi:10.1074/jbc.273.32.20551. ISSN 0021-9258.
PMID 9685412.
1
From Wikipedia, the free encyclopedia RANK
[6] ^ Darnay, B G; Ni J, Moore P A, Aggarwal B B (Mar. S1. doi:10.1186/ar2165. PMC 1924516.
1999). "Activation of NF-kappaB by RANK requires PMID 17634140.
tumor necrosis factor receptor-associated factor http://www.pubmedcentral.nih.gov/
(TRAF) 6 and NF-kappaB-inducing kinase. articlerender.fcgi?tool=pmcentrez&artid=1924516.
Identification of a novel TRAF6 interaction motif". • Hughes AE, Shearman AM, Weber JL, et al. (1994).
J. Biol. Chem. (UNITED STATES) 274 (12): 7724–31. "Genetic linkage of familial expansile osteolysis to
doi:10.1074/jbc.274.12.7724. ISSN 0021-9258. chromosome 18q.". Hum. Mol. Genet. 3 (2): 359–61.
PMID 10075662. doi:10.1093/hmg/3.2.359. PMID 7911698.
[7] ^ Galibert, L; Tometsko M E, Anderson D M, Cosman • Cody JD, Singer FR, Roodman GD, et al. (1997).
D, Dougall W C (Dec. 1998). "The involvement of "Genetic linkage of Paget disease of the bone to
multiple tumor necrosis factor receptor (TNFR)- chromosome 18q.". Am. J. Hum. Genet. 61 (5): 1117–22.
associated factors in the signaling mechanisms of doi:10.1086/301601. PMC 1716035. PMID 9345096.
receptor activator of NF-kappaB, a member of the http://www.pubmedcentral.nih.gov/
TNFR superfamily". J. Biol. Chem. (UNITED STATES) articlerender.fcgi?tool=pmcentrez&artid=1716035.
273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. • Anderson DM, Maraskovsky E, Billingsley WL, et al.
ISSN 0021-9258. PMID 9852070. (1997). "A homologue of the TNF receptor and its
[8] ^ Kim, H H; Lee D E, Shin J N, Lee Y S, Jeon Y M, ligand enhance T-cell growth and dendritic-cell
Chung C H, Ni J, Kwon B S, Lee Z H (Jan. 1999). function.". Nature 390 (6656): 175–9. doi:10.1038/
"Receptor activator of NF-kappaB recruits multiple 36593. PMID 9367155.
TRAF family adaptors and activates c-Jun N- • Haslam SI, Van Hul W, Morales-Piga A, et al. (1998).
terminal kinase". FEBS Lett. (NETHERLANDS) 443 "Paget’s disease of bone: evidence for a susceptibility
(3): 297–302. doi:10.1016/S0014-5793(98)01731-1. locus on chromosome 18q and for genetic
ISSN 0014-5793. PMID 10025951. heterogeneity.". J. Bone Miner. Res. 13 (6): 911–7.
doi:10.1359/jbmr.1998.13.6.911. PMID 9626621.
External links • Darnay BG, Haridas V, Ni J, et al. (1998).
"Characterization of the intracellular domain of
• MeSH RANK+Protein receptor activator of NF-kappaB (RANK). Interaction
with tumor necrosis factor receptor-associated
Further reading factors and activation of NF-kappab and c-Jun N-
terminal kinase.". J. Biol. Chem. 273 (32): 20551–5.
• Romas E, Gillespie MT, Martin TJ (2002). doi:10.1074/jbc.273.32.20551. PMID 9685412.
"Involvement of receptor activator of NFkappaB • Wong BR, Josien R, Lee SY, et al. (1998). "The TRAF
ligand and tumor necrosis factor-alpha in bone family of signal transducers mediates NF-kappaB
destruction in rheumatoid arthritis.". Bone 30 (2): activation by the TRANCE receptor.". J. Biol. Chem. 273
340–6. doi:10.1016/S8756-3282(01)00682-2. (43): 28355–9. doi:10.1074/jbc.273.43.28355.
PMID 11856640. PMID 9774460.
• Collin-Osdoby P (2005). "Regulation of vascular • Galibert L, Tometsko ME, Anderson DM, et al. (1999).
calcification by osteoclast regulatory factors RANKL "The involvement of multiple tumor necrosis factor
and osteoprotegerin.". Circ. Res. 95 (11): 1046–57. receptor (TNFR)-associated factors in the signaling
doi:10.1161/01.RES.0000149165.99974.12. mechanisms of receptor activator of NF-kappaB, a
PMID 15564564. member of the TNFR superfamily.". J. Biol. Chem. 273
• Clohisy DR, Mantyh PW (2005). "Bone cancer pain (51): 34120–7. doi:10.1074/jbc.273.51.34120.
and the role of RANKL/OPG.". Journal of PMID 9852070.
musculoskeletal & neuronal interactions 4 (3): 293–300. • Nakagawa N, Kinosaki M, Yamaguchi K, et al. (1999).
PMID 15615497. "RANK is the essential signaling receptor for
• Anandarajah AP, Schwarz EM (2006). "Anti-RANKL osteoclast differentiation factor in
therapy for inflammatory bone disorders: osteoclastogenesis.". Biochem. Biophys. Res. Commun.
Mechanisms and potential clinical applications.". J. 253 (2): 395–400. doi:10.1006/bbrc.1998.9788.
Cell. Biochem. 97 (2): 226–32. doi:10.1002/jcb.20674. PMID 9878548.
PMID 16240334. • Kim HH, Lee DE, Shin JN, et al. (1999). "Receptor
• Baud’huin M, Duplomb L, Ruiz Velasco C, et al. (2007). activator of NF-kappaB recruits multiple TRAF family
"Key roles of the OPG-RANK-RANKL system in bone adaptors and activates c-Jun N-terminal kinase.".
oncology.". Expert Rev Anticancer Ther 7 (2): 221–32. FEBS Lett. 443 (3): 297–302. doi:10.1016/
doi:10.1586/14737140.7.2.221. PMID 17288531. S0014-5793(98)01731-1. PMID 10025951.
• Boyce BF, Xing L (2007). "Biology of RANK, RANKL, • Darnay BG, Ni J, Moore PA, Aggarwal BB (1999).
and osteoprotegerin.". Arthritis Res. Ther. 9 Suppl 11: "Activation of NF-kappaB by RANK requires tumor
2
From Wikipedia, the free encyclopedia RANK
necrosis factor receptor-associated factor (TRAF) 6 PMID 10500098.
and NF-kappaB-inducing kinase. Identification of a http://www.pubmedcentral.nih.gov/
novel TRAF6 interaction motif.". J. Biol. Chem. 274 articlerender.fcgi?tool=pmcentrez&artid=317030.
(12): 7724–31. doi:10.1074/jbc.274.12.7724. • Hughes AE, Ralston SH, Marken J, et al. (2000).
PMID 10075662. "Mutations in TNFRSF11A, affecting the signal
• Hsu H, Lacey DL, Dunstan CR, et al. (1999). "Tumor peptide of RANK, cause familial expansile
necrosis factor receptor family member RANK osteolysis.". Nat. Genet. 24 (1): 45–8. doi:10.1038/
mediates osteoclast differentiation and activation 71667. PMID 10615125.
induced by osteoprotegerin ligand.". Proc. Natl. Acad. • Wong BR, Besser D, Kim N, et al. (2000). "TRANCE, a
Sci. U.S.A. 96 (7): 3540–5. doi:10.1073/pnas.96.7.3540. TNF family member, activates Akt/PKB through a
PMC 22329. PMID 10097072. signaling complex involving TRAF6 and c-Src.". Mol.
http://www.pubmedcentral.nih.gov/ Cell 4 (6): 1041–9. doi:10.1016/S1097-2765(00)80232-4.
articlerender.fcgi?tool=pmcentrez&artid=22329. PMID 10635328.
• Dougall WC, Glaccum M, Charrier K, et al. (1999).
"RANK is essential for osteoclast and lymph node This article incorporates text from the United States National
development.". Genes Dev. 13 (18): 2412–24. Library of Medicine, which is in the public domain.
doi:10.1101/gad.13.18.2412. PMC 317030.
Retrieved from "http://en.wikipedia.org/w/index.php?title=RANK&oldid=367138344"
Categories:
• Human proteins
• Membrane protein stubs
• Clusters of differentiation
• Cytokine receptors
This page was last modified on 10 June 2010 at 04:40. Text is available under the Creative Commons Attribution-
ShareAlike License; additional terms may apply. See Terms of use for details. Wikipedia® is a registered trademark of
the Wikimedia Foundation, Inc., a non-profit organization.Contact us
Privacy policy About Wikipedia Disclaimers
3