Curriculum Vitae for Timothy A. Cross, Professor of Chemistry &
NMR Spectroscopy & Imaging Program Director, National High Magnetic Field Laboratory
1800 E. Paul Dirac Dr., Tallahassee, FL 32306-4005
Education:
Trinity College Hartford, CT B.S. 1976 Chemistry
University of Penn. Philadelphia, PA Ph.D. 1981 Chemistry
Positions:
Department of Chemistry, University of Pennsylvania
Postdoctoral Fellow with Stanley J. Opella 1981-1983
Department of Biophysical Chemistry, Biozentrum der Universitat Basel
Postdoctoral Fellow with Joachim Seelig 1983-1984
Department of Chemistry, Florida State University
Assistant Professor 1984-1989
Associate Professor 1989-1993
Professor 1993-
Director of the FSU Nuclear Magnetic Resonance Facility 1984-
Department of Biological Science
Courtesy Associate Professor 1997-
Institute of Molecular Biophysics, Florida State University 1984-
Director of the Institute & Structural Biology Program 1991-1993
Center for Materials Res. & Tech., Florida State University 1990-
National High Magnetic Field Lab., Florida State University 1990-
Acting Director NMR Program 1991-1994
Director for New Initiatives 1995- 1997
Director of the NMR Program 1997-
Honors:
Phi Beta Kappa 1975-
Honors in Chemistry and General Scholarship 1976
Mary A. Terry Fellowship 1976-1978
Meritorious Teaching Awards 1977, 1978
NIH Predoctoral Trainee in Cell and Molecular Biology 1978-1981
NATO Postdoctoral Fellowship 1983-1984
NSF Presidential Young Investigator Award 1985-1990
Alfred P. Sloan Research Fellow 1988-1990
Florida State University Developing Scholar Award 1990-1991
Fellow of the American Academy for the Advancement of Science 1997-
Service:
NIH Molecular Cytology Study Section (ad hoc) 1988
NSF ILI Review Pannel 1989
NSF Biophysics Review Panel 1989-1992
NIH Shared Instrumentation Panel 1993
NIH Special Study Section 1993
NIH BBCB Study Section 1995-1999
Advisory Board - Magnetic Resonance in Chemistry 1997-2000
Editorial Board - J. Magnetic Resonance 1998-2000
Editorial Board - Biophysical Journal 1998-2001
Biophysical Society Council 2000-2003
5 Publications Most Closely Related to the Proposed Project:
Ketchem, R.R., Roux, B. & Cross, T.A. (1997) “High-Resolution Polypeptide Structure in a Lamellar
Phase Lipid Environment from Solid-State NMR Derived Orientational Constraints” Structure
5:1655-1669.
Fu, R. & Cross, T.A. (1999) “Solid-State NMR Investigation of Protein and Polypeptide Structure”
Annu. Rev. Biophys. Biomol. Struct. 28:235-268.
Fu, R., Cotten, M. & Cross, T.A. (2000) “Inter- and Intramolecular Distance Measurements by Solid
State Magic Angle Spinning NMR: Determination of Gramicidin A Channel Dimer Structure in
Hydrated Phospholipid Bilayers” J. Biomol. NMR 16:261-268.
Kovacs, F.A., Denny, J.K., Song, Z., Quine, J.R. & Cross, T.A. (2000) “Helix Tilt of the M2
Transmembrane Protein: An Intrinsic Property of the Protein” J. Mol. Biol. 295:117-125.
Wang, J., Denny, J.K., Tian, C., Kovacs, F.A., Song, Z., Fu, R., Quine, J.R. & Cross, T.A. (2000)
“Orientation of Membrane Protein Helical Wheels without Resonance Assignments from
PISEMA” J. Magn. Reson. 144:162-167.
5 Most Important Publications:
Arumugam, S., Pascal, S., North, C.L., Hu, W., Lee, K.-C., Cotten, M., Ketchem, R.R., Xu, F.,
Brenneman, M., Kovacs, F., Tian, F., Wang, A., Huo, S. and Cross, T.A. (1996) “Conformational
Trapping in a Membrane Environment: A Regulatory Mechanism for Protein Activity?” Proc.
Natl. Acad. Sci. U.S.A. 93:5872-5876.
Tian, F. & Cross, T.A. (1999) "Cation Transport: An Example of Structural Based Selectivity" J.
Mol. Biol. 285:1993-2003.
Xu, F & Cross, T.A. (1999) "Water: A "Foldase" that Catalyzes Hydrogen Bond Exchange in
Polypeptide Conformational Rearrangements" Proc. Natl. Acad. Sci. U.S.A. 96:9057-9061.
Kovacs, F., Quine, J. & Cross, T.A. (1999) “Validation of the Single-Stranded Channel Conformation
of Gramicidin A by Solid-State NMR” Proc. Natl. Acad. Sci. U.S.A. 96:7910-7915.
Cross, T.A., Arseniev, A., Cornell, B.A., Davis, J.H., Killian, J.A., Koeppe II, R.E., Nicholson, L.K.,
Separovic, F., & Wallace, B.A. (1999) “Gramicidin Channel Controversy - Revisited” Natur. Struct.
Biol. 6:610-611.
Collaborators:
Tetsuo Asakura, Tokyo Univ. of Agriculture & Technology; David Busath, Brigham Young University;
Larry Pinto, Northwestern University; Robert Lamb, Northwestern University; Christopher Miller,
Brandeis University; Ronald Kaback, UCLA
Graduate Students During the Past 5 years (out of a total of 23):
Myriam Cotten 8/92-12/98 PhD
Feng Xu 8/92-11/97 PhD
Fang Tian 8/92-5/98 PhD
Frank Kovacs 8/92-6/99 PhD
Junfeng Wang 8/95-
Zhang, Li 8/96-11/98 M.S.
Tian, Changlin 8/97-
Mo, Yiming 8/98-
Kim, Sanguk 8/98-
Hu, Jun 8/99-
Postdoctoral Fellows During the Past 5 years (out of a total of 8):
Dr. Anping Wang (1/95-1/96); Dr. Victoria Soghomonian (6/95-12/98); Dr. Zhiyan Song (7/97-
6/99); Dr. Katsuyuki Nishimura (5/99- )
Graduate & Postdoctoral Supervisors:
Stanley J. Opella, University of Pennsylvania
Joachim Seelig, University of Basel, Switzerland
Present Funding Support:
NIH AI-23007-14 “Correlations: Structure-Dynamics-Functional in Channels” Annual Direct Costs
„00-„01- $300k, 3/00 – 2/05, (Cross, PI; Fu, Co-PI; Busath, Co-PI).
NSF MCB 9986036 “Solid State NMR-derived Structure: Backbone of the Influenza A M2 Protein”
Total Annual Direct Costs - $95k, 2/00 – 1/03, (Cross, PI; Fu, Co-PI; Quine, Co-PI).
NSF DMR 9603935 “830 MHz Spectrometer for the National High Magnetic Field Lab.” Total
Direct Costs - $558k, 2/98 – 1/01, (Cross, PI; Edison, Co-PI; Gibbs, Co-PI; Markiewicz, Co-PI).