The latest -Cell-Based Assays for Drug Discovery -Report By Aarkstore by aarks222


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									                Cell-Based Assays for Drug Discovery

The area of drug discovery tools is one of the newest and most important sectors of pharmaceutical
research and development. The term drug discovery tools usually refers to high-content screening
(HCS) and analysis and is composed of those applications that require sufficient levels of sample
throughput, whereby complex cellular events and phenotypes can be studied. Elements of drug
performance like toxicity and specificity can be established simultaneously using mixed cell types--
primary cells, cell lines, cell subpopulations. HCS seeks to assess the impact of phenotypic and
cellular changes that are brought about by gene modification (such as with RNA interference (RNAi)
approaches) and/or drug (or compound) treatment. The purpose of this examination by TriMark
Publications is to describe the specific segments of the global drug discovery tools market. Within
this area, the report covers those segments that are highly active in terms of innovation and growth.
Specifically, this study examines the markets for small lab equipment all the way up to highly
automated, large automated platforms, as well as accessory equipment such as reagents, supplies
and manufacturers’ original equipment manufacturer (OEM) additional equipment.

Table of Contents :

1. Overview 4

1.1 Objectives of the Report 4

1.2 Methodology 5

1.3 Scope of the Report 6

1.4 Executive Summary 7

2. Technologies and Product Offering for High-Content Analysis 10

2.1 Definition of High-Content Analysis and Why It Is So Attractive a Discipline


2.2 Classes of Measurements Possible with High-Content Analysis Approaches and

Biological Functions Investigated 14


Figure 2.1: Scope of Biological Parameters Addressed Via a Typical High-Content

Analysis Experiment 13

Figure 2.2: Classes of Assays in Life Science Research and Drug Discovery

Illustrating the Relationship between Cell-based Assays and High-Content

Analysis 14

Table 2.1: Comparison of the Key Features of High-Content Analysis and

High-Throughput Screening 11

Table 2.2: Impact of High-Content Analysis on Drug Discovery-Impact of Several

Drivers 12

Table 2.3: Biological Application Areas Associated with High-Content Analysis 13

Table 2.4: Classes of Measurements and Targets Identified Using Phenotypic

Screening (High-Content Analysis) 14

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