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LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH

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LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH Powered By Docstoc
					RESEARCH INFRASTRUCTURE
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
MERAL ÖZGÜÇ Hacettepe University, Faculty of Medicine FP6-National Contact Point -LIFE

Organisation of Research and Education
Life Sciences
• Universities

Genomics
• Clinical Labs

Biotechnology
• Graduate

Medical Schools
Medical Biology

• Genetic
Services

Programs
• Institutes

• Faculty of Science • Infrastructure

Dept. of
Mol. Biol.and Gen.

Biological Resource Centers
• Oncology Institutes

(MoH - Cancer Registries)
Özgüç, 30 June 2003

Life Sciences
Departments of Molecular Biology and Genetics (1990’s)

Research and Education
METU (Middle East Technical University), Ankara Bogazici University, Istanbul

Bilkent University, Ankara
Departments of Medical Biology (1980’s)

Research / Education - Diagnostic Units, Genetic Testing

Özgüç, 30 June 2003

HISTORY OF MEDICAL GENETICS
1964 - Establishment of Genetic Units Departments of Pediatrics - Clinical Genetics and Cytogenetics Ankara University Hacettepe University, Ankara Istanbul University
2003 --- 25-30 laboratories for cytogenetic analysis

1990’ s - Molecular Genetics Diagnostics Units
500 - 1000 genetic tests / year (6 Universities, 10 Labs)

Hacettepe Uni., Ankara Uni.,
Istanbul Uni., 9 Eylül (Izmir), Akdeniz Uni. (Antalya), Bilkent Uni. (Ankara)
Özgüç, 30 June 2003

Population Background : Demography / Infrastructure Population : ~ 68 million (census 2000) Demographic indicators : 0-14 yrs % 30

15-64 yrs
65 yrs+

% 64.4
% 5.6

Infant mortality rate (per thousand):

1993 - 53

1997 - 39.8

2000 - 35.3

Control of diarrheal diseases and upper respiratory tract infections

Emergence of genetic disorders and childhood cancers

Özgüç, 30 June 2003

Population Indicators for Medical Genetic Research • Consanguinity : 21 % (general population) 35 % Eastern Anatolia contributes to high incidence of autosomal recessive inherited disorders • Long child bearing age esp. in rural areas • Large families with multiple affecteds • Large pedigrees suitable for identification of new disease genes • Unique gene pool : long history of migrations,

region specific disorders

Özgüç, 30 June 2003

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Özgüç, 30 June 2003

Genomics

• Genetic Epidemiology
Single Gene Disorders Common Disorders Familial Cancers • Identification of New Disease Genes (Homozygosity Mapping) Infrastructure - Biological Resource Centers 1995 - TUBITAK DNA/Cell Bank (www.dna.tubitak.gov.tr) Registry for rare genetic disorders
Özgüç, 30 June 2003

Genomics Single Gene Disorders
• Hemoglobinopathies • Familial Mediterranean Fever (FMF)

• Neurological and Metabolic Disorders Hyperphenilalanemia (~ 1/4,000) * DMD, SMA, Storage disorders, galactosemia, CF, mitochondrial cytopathies

Özgüç, 30 June 2003

Genomics Cancer Genetics

• Bilkent University (Ankara)
(Hepatocellular carcinoma, breast / prostate cancers) • Oncology Institutes (Istanbul, 9 Eylül - Izmir, Hacettepe - Ankara) Ministry of Health - Cancer Control Dept. Cancer Registry

Genetic Epidemiology of Familial Cancers
High Regional Prevelance - Mesothelioma (www.tr-mesothelioma.org.tr)
Özgüç, 30 June 2003

Identification of New Disease Genes

Topaloğlu, H., Pınarlı, G., Erdem, H., Gücüyener, K., Karaduman, A., Topçu, M., Akarsu, A. N., Özgüç, M., 1998. Clinical Observations in Autosomal Recessive Spastic Paraplegia in Childhood and Further Evidence for Genetic Heterogeneity. Neuropediatrics., 29: 189194. Topçu, M., Gartioux, C., Ribierre, F., Yalçınkaya, C., Tokuş, E., Öztekin, N., Beckmann, J. S., Özgüç, M., and Seboun, E., 2000. Vacuoliting Megalencephalic Leukoencephalopathy with Subcortical Cysts, Mapped to Chromosome 22qtel. Am. J. Hum. Genet, 66(2):733739.
Özgüç, 30 June 2003

Biotechnology
MRC-TUBITAK- Genetic Engineering and Biotechnology Research Institute) - Istanbul METU (Institute of Natural and Applied SciencesBiotechnology Graduate Program) - Ankara Depts of Bio, Chem, Chem Eng,Food Eng, Env Sci Ege University (Biotechnology Research Center) - Izmir

Özgüç, 30 June 2003

Biotechnology
MRC-TUBITAK- Genetic Engineering and Biotechnology Research Institute) - Istanbul Transgenic Animal Lab Molecular Bioenergetics Plant Biotechnology and Molecular Genetics Immunogenetics Hybridoma Technology

Molecular Cell Biology
Industrial Enzymes
Özgüç, 30 June 2003

Biotechnology METU (Institute of Natural and Applied SciencesBiotechnology Graduate Program) - Ankara Plant Biotechnology

Industrial Enzyme Processing
Energy Production Drug resistance

Production & application of bioactive materials
Bioremediation Fungal biotechnology
Özgüç, 30 June 2003

INTEGRATION

Life/genomics
Epidemiology

Biotechnology
New diagnostic tools

Genetic testing
New genes Therapy
Development of highthroughput technologies

Cellular and Gene
Therapies Drug Design Tissue Engineering
Özgüç, 30 June 2003

Collaborations with Centers in France * TUBITAK - CNRS

* Genepole, Evry
CNG (The National Center for Genotyping) CNS (The National Center for Sequencing)

Genethon
- Gene Therapies Research and Applications Center - DNA Bank
Özgüç, 30 June 2003

TUBITAK- International memberships and committees
(Related to genomics and biotechnology for health)

EMBO (European Molecular Biology Organisation)
ICGEB (International Centre for Genetic Engineering
and Biotechnology)

ESF - Integrated Approaches to Functional Genomics
2002-2006

OECD
WPB (Working Party on Biotechnology) 2000WG-HHRB (Human health related biotechnologies)
Özgüç, 30 June 2003


				
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