Martinez

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					                            Fernando J. Martinez, M.D., M.S.



Faculty Appointment:        Professor of Internal Medicine
                            Director, Pulmonary Diagnostic Services
                            Co-Medical Director, Lung Transplantation

Specialty:                  Pulmonary & Critical Care Medicine

Clinical Interests:         Interstitial lung disease, COPD, lung transplantation,
                            exercise physiology, respiratory muscle function, pulmonary
                            rehabilitation, dyspnea, cost-effective use of diagnostic
                            resources, lung volume reduction.

Research Interests:         Interstitial lung disease, COPD, respiratory muscle function,
                            physiologic response to lung transplantation, optimal
                            diagnostic approach to the evaluation of dyspnea.

Degree:                     M.D., 1983, University of Florida School of Medicine
                            M.S., 2001, University of Michigan School of Public Health
                            Biostatistics and Clinical Study Design

Residency:                  Beth Israel Hospital 1984-1986

Fellowships:                Boston University Pulmonary Center 1986-1989

Certifications:             1986, Internal Medicine
                            1988, Pulmonary Medicine
                            1989, Critical Care Medicine

Faculty Appointment Date:   9/01/1991

Clinical Address:           A. Alfred Taubman Health Care Center
                            3rd Floor Taubman Center, Reception Area’s A & C
                            3916 Taubman Center
                            1500 E. Medical Center Drive
                            Ann Arbor, MI 48109-5360

Appointments:               Toll Free: 1-888-284-5864 (LUNG) or (734) 763-7668
Nursing:                         Toll Free: 1-888-284-5864 (LUNG) or (734) 763-7668
                                 Option selections: Appointments – 1
                                 Medical Records – 2; Billing – 3; Test Results – 4
                                 Prescription Refills – 5
                                 Leave a message or to speak to a nurse - 6

M-Line physician consultation: 1-800-962-3555
Clinic Fax:                    (734) 936-3494

Academic Office Address:         University of Michigan Health System
                                 3916 Taubman Center
                                 1500 E. Medical Center Drive
                                 Ann Arbor, MI 48109-5360

Academic Office Telephone:       (734) 763-2540
Academic Office Fax:             (734) 936-5048

Recent Articles:
1.    Han MK, McLaughlin VV, Criner GJ, Martinez FJ. Pulmonary diseases and the heart.
      Circulation. 2007;116(25):2992-3005. http://www.ncbi.nlm.nih.gov/pubmed/18086941
2.    Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, Wilke CA, Flaherty KR, Martinez FJ,
      Tsui JL, Sheppard D, Baralle FE, Toews GB, White ES. An essential role for fibronectin
      extra type III domain A in pulmonary fibrosis. Am J Respir Crit Care Med.
      2008;177(6):638-45. http://www.ncbi.nlm.nih.gov/pubmed/18096707
3.    Travis WD, Hunninghake G, King TE Jr, Lynch DA, Colby TV, Galvin JR, Brown KK,
      Chung MP, Cordier JF, du Bois RM, Flaherty KR, Franks TJ, Hansell DM, Hartman TE,
      Kazerooni EA, Kim DS, Kitaichi M, Koyama T, Martinez FJ, Nagai S, Midthun DE, Müller
      NL, Nicholson AG, Raghu G, Selman M, Wells A. Idiopathic nonspecific interstitial
      pneumonia: report of an American Thoracic Society project. Am J Respir Crit Care
      Med.2008;178(2): 211. http://www.ncbi.nlm.nih.gov/pubmed/18388353
4.    Martinez FJ, Raczek AE, Seifer FD, Conoscenti CS, Curtice TG, D'Eletto T, Cote C,
      Hawkins C, Phillips AL; COPD-PS Clinician Working Group. Development and initial
      validation of self-scored COPD Population Screener Questionnaire (COPD-PS). COPD.
      2008;5(2):85-95. http://www.ncbi.nlm.nih.gov/pubmed/18415807
5.    Minai OA, Benditt J, Martinez FJ. Natural history of emphysema. Proc Am Thorac Soc.
      2008;5(4):468-74. http://www.ncbi.nlm.nih.gov/pubmed/18453357
6.    Martinez FJ, Han MK, Andrei AC, Wise R, Murray S, Curtis JL, Sternberg A, Criner G,
      Gay SE, Reilly J, Make B, Ries AL, Sciurba F, Weinmann G, Mosenifar Z, DeCamp M,
      Fishman AP, Celli BR; National Emphysema Treatment Trial Research Group.
      Longitudinal change in the BODE index predicts mortality in severe emphysema. Am J
      Respir Crit Care Med. 2008;178(5):491-9.
      http://www.ncbi.nlm.nih.gov/pubmed/18535255
7.    Attili AK, Kazerooni EA, Gross BH, Flaherty KR, Myers JL, Martinez FJ. Smoking-related
      interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics.
      2008;28(5):1383-96; discussion 1396-8. http://www.ncbi.nlm.nih.gov/pubmed/18794314
8.    Sundaram B, Gross BH, Martinez FJ, Oh E, Müller NL, Schipper M, Kazerooni EA.
      Accuracy of high-resolution CT in the diagnosis of diffuse lung disease: effect of
      predominance and distribution of findings. AJR Am J Roentgenol. 2008;191(4):1032-9.
      http://www.ncbi.nlm.nih.gov/pubmed/18806139
9.    Martinez FJ, Curtis JL, Albert R. Role of macrolide therapy in chronic obstructive
      pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2008;3(3):331-50.
      http://www.ncbi.nlm.nih.gov/pubmed/18990961
10.   Make BJ, Martinez FJ. Assessment of patients with chronic obstructive pulmonary
      disease. Proc Am Thorac Soc. 2008;5(9):884-90.
      http://www.ncbi.nlm.nih.gov/pubmed/19056711
11.   Fell CD, Liu LX, Motika C, Kazerooni EA, Gross BH, Travis WD, Colby TV, Murray S,
      Toews GB, Martinez FJ, Flaherty KR. The prognostic value of cardiopulmonary exercise
      testing in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2009;179(5):402-7.
      http://www.ncbi.nlm.nih.gov/pubmed/19074597
12.   Chan KM, Martinez FJ, Chang AC. Nonmedical therapy for chronic obstructive
      pulmonary disease. Proc Am Thorac Soc. 2009;6(1):137-45.
      http://www.ncbi.nlm.nih.gov/pubmed/19131539
13.   Joshi AD, Fong DJ, Oak SR, Trujillo G, Flaherty KR, Martinez FJ, Hogaboam CM.
      Interleukin-17-mediated immunopathogenesis in experimental hypersensitivity
      pneumonitis. Am J Respir Crit Care Med. 2009;179(8):705-16.
      http://www.ncbi.nlm.nih.gov/pubmed/19151189
14.   Hyett B, Martinez FJ, Gill BM, Mehra S, Lembo A, Kelly CP, Leffler DA. Delayed
      radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of
      gastroparesis. Gastroenterology. 2009;137(2):445-52.
      http://www.ncbi.nlm.nih.gov/pubmed/19410575
15.   Kim WJ, Silverman EK, Hoffman E, Criner GJ, Mosenifar Z, Sciurba FC, Make BJ, Carey
      V, Estépar RS, Diaz A, Reilly JJ, Martinez FJ, Washko GR; NETT Research Group. CT
      metrics of airway disease and emphysema in severe COPD. Chest. 2009;136(2):396-
      404. http://www.ncbi.nlm.nih.gov/pubmed/19411295
16.   Clark NM, Dodge JA, Partridge MR, Martinez FJ. Focusing on outcomes: making the
      most of COPD interventions. Int J Chron Obstruct Pulmon Dis. 2009;4:61-77.
      http://www.ncbi.nlm.nih.gov/pubmed/19436690
17.   Benzo R, Farrell MH, Chang CC, Martinez FJ, Kaplan R, Reilly J, Criner G, Wise R,
      Make B, Luketich J, Fishman AP, Sciurba FC; NETT Research Group. Integrating health
      status and survival data: the palliative effect of lung volume reduction surgery. Am J
      Respir Crit Care Med. 2009;180(3):239-46.
      http://www.ncbi.nlm.nih.gov/pubmed/19483114
18.   Bailey WC, Sciurba FC, Hanania NA, Donohue JF, Ferguson GT, Zibrak JD,
      Sharafkhaneh A, Marcus P, Rosa K, Piault EC, Martinez FJ. Development of validation
      of the Chronic Obstructive Pulmonary Disease Assessment Questionnaire (COPD-AQ).
      Prim Care Respir J. 2009;18(3):198-207. http://www.ncbi.nlm.nih.gov/pubmed/19492178
19.   Dransfield MT, Nahm MH, Han MK, Harnden S, Criner GJ, Martinez FJ, Scanlon PD,
      Woodruff PG, Washko GR, Connett JE, Anthonisen NR, Bailey WC; COPD Clinical
      Research Network. Superior immune response to protein-conjugate versus free
      pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease. Am J
      Respir Crit Care Med. 2009;180(6):499-505.
      http://www.ncbi.nlm.nih.gov/pubmed/19556517
20.   Hoeper MM, Barberà JA, Channick RN, Hassoun PM, Lang IM, Manes A, Martinez FJ,
      Naeije R, Olschewski H, Pepke-Zaba J, Redfield MM, Robbins IM, Souza R, Torbicki A,
      McGoon M. Diagnosis assessment, and treatment of non-pulmonary arterial
      hypertension pulmonary hypertension. J Am Coll Cardiol. 2009;54(1 Suppl):S85-96.
      http://www.ncbi.nlm.nih.gov/pubmed/19555862
21.   Hecker L, Vittal R, Jones T, Jagirdar R, Luckhardt TR, Horowitz JC, Pennathur S,
      Martinez FJ, Thannickal VJ. NADPH oxidase-4 mediates myofibroblast activation and
      fibrogenic response to lung injury. Nat Med. 2009 Sep;15(9):1077-81.
      http://www.ncbi.nlm.nih.gov/pubmed/19701206
22.   Fabbri LM, Calverley PM, Izquierdo-Alonso JL, Bundschuh DS, Brose M, Martinez FJ,
      Rabe KF; M2-127 and M2-128 study groups. Lancet. 2009;374(9691):695-703.
      http://www.ncbi.nlm.nih.gov/pubmed/19716961
23.   Calverley PM, Rabe KF, Goehring UM, Kristiansen S, Fabbri LM, Martinez FJ; M2-124
      and M2-125 study groups. Roflumilast in symptochronic obstructive pulmonary disease:
      two randomised clinical trials. Lancet. 2010;376(9747):1146.
      http://www.ncbi.nlm.nih.gov/pubmed/19716960
24.   Freeman CM, Martinez FJ, Han MK, Ames TM, Chensue SW, Todt JC, Arenberg DA,
      Meldrum CA, Getty C, McCloskey L, Curtis JL. Lung dendritic cell expression of
      maturation molecules increase with worsening chronic obstructive pulmonary disease.
      Am J Respir Crit Care Med. 2009;180(12):1179-88.
      http://www.ncbi.nlm.nih.gov/pubmed/19729666
25.   Horowitz JC, Martinez FJ, Thannickal VJ. Mesenchymal cell fate and phenotypes in the
      pathogenesis of emphysema. COPD. 2009;6(3):201-10.
      http://www.ncbi.nlm.nih.gov/pubmed/19811376
26.   Matsuoka S, Washko GR, Yamashiro T, Estepar RS, Diaz A, Silverman EK, Hoffman E,
      Fessler HE, Criner GJ, Marchetti N, Scharf SM, Martinez FJ, Reilly JJ, Hatabu H;
      National Emphysema Treatment Trial Research Group. Pulmonary hypertension and
      computed tomography measurement of small pulmonary vessels in severe emphysema.
      Am J Respir Crit Care Med. 2010;181(3):218-25.
      http://www.ncbi.nlm.nih.gov/pubmed/19875683
27.   Han MK, Bartholmai B, Liu LX, Murray S, Curtis JL, Sciurba FC, Kazerooni EA,
      Thompson B, Frederick M, Li D, Schwarz M, Limper A, Freeman C, Landreneau RJ,
      Wise R, Martinez FJ. Clinical significance of radiologic characterizations in COPD.
      COPD. 2009;6(6):459-67. http://www.ncbi.nlm.nih.gov/pubmed/19938970
28.   Washko GR, Martinez FJ, Hoffman EA, Loring SH, Estépar RS, Diaz AA, Sciurba FC,
      Silverman EK, Han MK, Decamp M, Reilly JJ; National Emphysema Treatment Trial
      Research Group. Physiological and computed tomographic predictors of outcome from
      lung volume reduction surgery. Am J Respir Crit Care Med. 2010;181(5):494-500.
      http://www.ncbi.nlm.nih.gov/pubmed/19965810
29.   Han MK, Swigris J, Liu L, Bartholmai B, Murray S, Giardino N, Thompson B, Frederick
      M, Li D, Schwarz M, Limper A, Flaherty K, Martinez FJ. Gender influences Health-
      Related Quality of Life in IPF. Respir Med. 2010;104(5):724-30.
      http://www.ncbi.nlm.nih.gov/pubmed/20036113
30.   Fell CD, Martinez FJ, Liu LX, Murray S, Han MK, Kazerooni EA, Gross BH, Myers J,
      Travis WD, Colby TV, Toews GB, Flaherty KR. Clinical predictors of diagnosis of
      idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2010;181(8):832-7.
      http://www.ncbi.nlm.nih.gov/pubmed/20056903
31.   Giardino ND, Curtis JL, Abelson JL, King AP, Pamp B, Liberzon I, Martinez FJ. The
      impact of panic disorder on interoception and dyspnea reports in chronic obstructive
      pulmonary disease. Biol Psychol. 2010. http://www.ncbi.nlm.nih.gov/pubmed/20176074
32.   Giardino ND, Curtis JL, Andrei AC, Fan VS, Benditt JO, Lyubkin M, Naunheim K, Criner
      G, Make B, Wise RA, Murray SK, Fishman AP, Sciurba FC, Liberzon I, Martinez FJ;
      NETT Research Group. Anxiety is associated with diminished exercise performance and
      quality of life in severe emphysema: a cross-sectional study. Respir Res. 2010;11:29.
      http://www.ncbi.nlm.nih.gov/pubmed/20214820
33.   Hanania NA, Mannino DM, Yawn BP, Mapel DW, Martinez FJ, Donohue JF, Kosinski M,
      Rendas-Baum R, Mintz M, Samuels S, Jhingran P, Dalal AA. Predicting risk of airflow
      obstruction in primary care: Validation of the lung function questionnaire (LFQ). Respir
      Med. 2010;104(8):1160-70. http://www.ncbi.nlm.nih.gov/pubmed/20226647
34.   Cho MH, Washko GR, Hoffmann TJ, Criner GJ, Hoffman EA, Martinez FJ, Laird N, Reilly
      JJ, Silverman EK. Cluster analysis in severe emphysema subjects using phenotype ad
      genotype data: an exploratory investigation. Respir Res. 2010;11:30.
      http://www.ncbi.nlm.nih.gov/pubmed/20233420
35.   Benzo RP, Chang CC, Farrell MH, Kaplan R, Ries A, Martinez FJ, Wise R, Make B,
      Sciurba F; NETT Research Group. Physical activity, health status and risk of
      hospitalization in patients with severe chronic obstructive pulmonary disease.
      Respiration. 2010;80(1):10-8. http://www.ncbi.nlm.nih.gov/pubmed/20234126
36.   Yawn BP, Mapel DW, Mannino DM, Martinez FJ, Donohue JF, Hanania NA, Kosinski M,
      Rendas-Baum R, Mintz M, Samuels S, Dalal AA; Lung Function Questionnaire Working
      Group. Development of Lung Function Questionnaire (LFQ) to identify airflow
      obstruction. Int J Chron Obstruct Pulmon Dis. 2010;5:1-10.
      http://www.ncbi.nlm.nih.gov/pubmed/20368906
37.   Schneider D, Ganesan S, Comstock AT, Meldrum CA, Mahidhara R, Goldsmith AM,
      Curtis JL, Martinez FJ, Hershenson MB, Sajjan U. Increased cytokine response of
      rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease. Am J
      Respir Crit Care Med. 2010;182(3):332-40.
      http://www.ncbi.nlm.nih.gov/pubmed/20395558
38.   Freeman CM, Han MK, Martinez FJ, Murray S, Liu LX, Chensue SW, Polak TJ, Sonstein
      J, Todt JC, Ames TM, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL.
      Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary
      disease severity and with in vitro stimulation by IL-18 or IL-15. J Immunol. 2010
      ;184(11):6504-13. http://www.ncbi.nlm.nih.gov/pubmed/20427767
39.   Han MK, Agusti A, Calverley PM, Celli BR, Criner G, Curtis JL, Fabbri LM, Goldin JG,
      Jones PW, Macnee W, Make BJ, Rabe KF, Rennard SI, Sciurba FC, Silverman EK,
      Vestbo J, Washko GR, Wouters EF, Martinez FJ. Chronic obstructive pulmonary disease
      phenotypes: the future of COPD. Am J Respir Crit Care Med. 2010;182(5):598-604.
      http://www.ncbi.nlm.nih.gov/pubmed/20522794
40.   Ganesan S, Faris AN, Comstock AT, Chattoraj SS, Chattoraj A, Burgess JR, Curtis JL,
      Martinez FJ, Zick S, Hershenson MB, Sajjan US. Quercetin prevents progression of
      disease in elastase/LPS-exposed mice by negatively regulating MMP expression. Respir
      Res. 2010;11:131. http://www.ncbi.nlm.nih.gov/pubmed/20920189

				
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posted:1/9/2012
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