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patient data

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patient  data
Repeated Measures:

2 x 2 within Ss







TREATMENT

(1) a b ab

1 12 20 12 30

2 13 21 13 31

3 14 22 14 32

4 15 23 15 33

PERSON 5 16 24 16 34

(SUBJECT) 6 17 25 17 35

7 18 26 18 36

8 19 27 19 37

9 20 28 20 38

10 21 29 21 39



Models (simple, without subject-by-treatment interactions):

ANOVA:--

For persons i = 1,2,…,10; levels j of A, j = 0,1; and levels k of B, k = 0,1,

y(ijk) = m + p(i) + a(j) + b(k) + (ab)(jk) + e(ijk)



Multiple regression:--

For I = 1,2, . . . , 40,

y(i) = d + b1S1(i) + b2S2(i) . . . + b9S9(i) + aA(i) + bB(i) + gG(i) + e(i)

that is, constant + subject variables + A variable + B variable + Interaction variable + error.

TREATMENT

Subject (1) a b ab

1 12 14 15 19

2 13 15 16 9

3 14 8 14 18

4 15 16 18 17

5 16 17 19 16

6 17 20 20 24

7 18 19 21 25

8 19 22 22 26

9 20 18 23 12

10 21 24 24 28

TREATMENT VALUES OF CONTRASTS

Subject (1) a b ab (1) A B

1 12 14 15 19 60 6 8

2 13 15 16 9 53 -5 -3

3 14 8 14 18 54 -2 10

4 15 16 18 17 66 0 4

5 16 17 19 16 68 -2 2

6 17 20 20 24 81 7 7

7 18 19 21 25 83 5 9

8 19 22 22 26 89 7 7

9 20 18 23 12 73 -13 -3

10 21 24 24 28 97 7 7



CONTRASTS

1 1 1 1 1

A -1 1 -1 1

B -1 -1 1 1

AB 1 -1 -1 1

AB

2

-9

10

-2

-4

1

3

1

-9

1

Data in stacked form Data in form for analysis by multiple regression

Person A B Y S1 S2 S3 S4 S5 S6 S7 S8 S9 A B G Y

1 0 0 12 1 0 0 0 0 0 0 0 0 0 0 0 12

1 1 0 14 1 0 0 0 0 0 0 0 0 1 0 0 14

1 0 1 15 1 0 0 0 0 0 0 0 0 0 1 0 15

1 1 1 19 1 0 0 0 0 0 0 0 0 1 1 1 19

2 0 0 13 0 1 0 0 0 0 0 0 0 0 0 0 13

2 1 0 15 0 1 0 0 0 0 0 0 0 1 0 0 15

2 0 1 16 0 1 0 0 0 0 0 0 0 0 1 0 16

2 1 1 9 0 1 0 0 0 0 0 0 0 1 1 1 9

3 0 0 14 0 0 1 0 0 0 0 0 0 0 0 0 14

3 1 0 8 0 0 1 0 0 0 0 0 0 1 0 0 8

3 0 1 14 0 0 1 0 0 0 0 0 0 0 1 0 14

3 1 1 18 0 0 1 0 0 0 0 0 0 1 1 1 18

4 0 0 15 0 0 0 1 0 0 0 0 0 0 0 0 15

4 1 0 16 0 0 0 1 0 0 0 0 0 1 0 0 16

4 0 1 18 0 0 0 1 0 0 0 0 0 0 1 0 18

4 1 1 17 0 0 0 1 0 0 0 0 0 1 1 1 17

5 0 0 16 0 0 0 0 1 0 0 0 0 0 0 0 16

5 1 0 17 0 0 0 0 1 0 0 0 0 1 0 0 17

5 0 1 19 0 0 0 0 1 0 0 0 0 0 1 0 19

5 1 1 16 0 0 0 0 1 0 0 0 0 1 1 1 16

6 0 0 17 0 0 0 0 0 1 0 0 0 0 0 0 17

6 1 0 20 0 0 0 0 0 1 0 0 0 1 0 0 20

6 0 1 20 0 0 0 0 0 1 0 0 0 0 1 0 20

6 1 1 24 0 0 0 0 0 1 0 0 0 1 1 1 24

7 0 0 18 0 0 0 0 0 0 1 0 0 0 0 0 18

7 1 0 19 0 0 0 0 0 0 1 0 0 1 0 0 19

7 0 1 21 0 0 0 0 0 0 1 0 0 0 1 0 21

7 1 1 25 0 0 0 0 0 0 1 0 0 1 1 1 25

8 0 0 19 0 0 0 0 0 0 0 1 0 0 0 0 19

8 1 0 22 0 0 0 0 0 0 0 1 0 1 0 0 22

8 0 1 22 0 0 0 0 0 0 0 1 0 0 1 0 22

8 1 1 26 0 0 0 0 0 0 0 1 0 1 1 1 26

9 0 0 20 0 0 0 0 0 0 0 0 1 0 0 0 20

9 1 0 18 0 0 0 0 0 0 0 0 1 1 0 0 18

9 0 1 23 0 0 0 0 0 0 0 0 1 0 1 0 23

9 1 1 12 0 0 0 0 0 0 0 0 1 1 1 1 12

10 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 21

10 1 0 24 0 0 0 0 0 0 0 0 0 1 0 0 24

10 0 1 24 0 0 0 0 0 0 0 0 0 0 1 0 24

10 1 1 28 0 0 0 0 0 0 0 0 0 1 1 1 28


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