PowerPoint Presentation by HC120104112643

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									                       Interaction of cells
                       with the environment
Unit Outline:
What is outside the cell and how do cells
 communicate with what’s “out there”?
How do cells interact with their external
  environment?
How do cells interact with each other?
Extracellular
space
                     Extracellular
                     space
 basal surface of
ectodermal cell of
  chick embryo




                     apical surface of
                       epithelial cell
                      from intestinal
                           lining
                      Extracellular matrix
     basement
membrane between
  blood vessels of
glomerus and renal
      tubules                     collagen



                       epidermis pulled
                     away from basement
                          membrane
Extracellular matrix
                   Extracellular matrix
Proteins of ECM - collagen
                 Extracellular matrix
Proteins of ECM - proteoglycans
Extracellular matrix




  Proteins of ECM
    - fibronectin
            Extracellular matrix




collagen


                Proteins of ECM
                    - laminin

           laminin
            Interaction of cells with ECM
INTEGRINS




    inactive
                  Interaction of cells with ECM
INTEGRINS
 ligands have
   RGD motif




differentiation
    motility
    growth
    survival       functions of outside-in signals
    Interaction of cells with ECM

FOCAL ADHESIONS



                           FA
           Interaction of cells with ECM




 FOCAL
ADHESION
   S
 Interaction of cells with ECM

HEMIDESMOSOMES
Interaction of cells with ECM
     Interaction of cells with cells
CELL ADHESION MOLECULES
     Interaction of cells with cells
CELL ADHESION MOLECULES
     Interaction of cells with cells
CELL ADHESION MOLECULES
Interaction of cells with
 ECM and other cells




   CELL ADHESION MOLECULES
              VS
  ECM ATTACHMENT MOLECULES
                      vocabulary
extracellular space           talin
extracellular matrix          vinculin
basement membrane             actinin
glycocalyx                    hemidesmosome
collagen                      cell adhesion molecule
fibronectin                   selectin
proteoglycan                  lectin
GAG chains                    Immunoglobulin superfamily
laminin                       cadherin
inside-out signaling          tight junction
outside-in signaling          adherins junction
focal adhesion                desmosome
focal adhesion kinase (FAK)   gap junction
actin
keratin
Extracellular
Matrix
Unit Learning Goals:
the extracellular space:

a. discuss the concept that the physical interactions
   between cells and their extracellular environment
   is highly specific as a result of molecular
   interactions between molecules on the cell with
   molecules in the matrix between cells and
   molecules on neighboring cells
b. describe the molecular components of the
   extracellular matrix (ECM) and discuss the
   cellular processes regulated by interactions
   between cells and their extracellular environment
interaction of cells with ECM:

a. compare the structure, function and signaling
   activity of integrins and “true” ECM proteins like
   collagen, laminin, and proteoglycans
b. comapre the structure and functions of molecular
   structures formed at the site of attachment of
   cells to an artificial substrate (focal adhesion) and
   to the basement membrane (hemidesmosome)
interaction of cells with other cells:

a. describe the general class of proteins mediating
   interactions between cells (cell adhesion
   molecules) using specific examples
b. compare the functions of cell adhesion molecules
   and extracellular matrix attachment molecules
c. discuss why insoluble solutes, whch cannot
   freely diffuse through the plasma membrane, also
   cannot pass freely between cells of an epithelial
   layer, and what would happen to tissues of they
   could
d. compare tight junctions, adherins
   junctions, desmosomes, and gap
   junctions in terms of structure, function
   and the type of cells in which they are
   found
e. draw, in cross section, two neighboring
   epithelial cells and illustrate the relative
   location and general structure of adherins
   junctions, desmosomes, tight junctions
   and gap junctions

								
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