From Wikipedia, the free encyclopedia Murid herpesvirus 68
Murid herpesvirus 68
Murid herpesvirus 68 differs from the corresponding MHV-72 gene by five
point mutations which alter four codons.[4] Glycoprotein
Virus classification 150 allows MHV-68 to bind to B-cells.[5]
Group: Group I (dsDNA)
Family: Herpesviridae References
Subfamily: Gammaherpesvirinae [1] Herbet W. Virgin IV, Philip Latreille, Pamela
Wamsley, Kymberlie Hallsworth, Karen E. Weck,
Genus: Rhadinovirus
Albert J. Dal Canto, and Samuel H. Speck (August
Species: Murid herpesvirus 4 1997). "Complete sequence and genomic analysis of
murine gammaherpesvirus 68". Journal of Virology
Subspecies: Murid herpesvirus 68 (MHV-68)
71 (8): 5894–904. http://jvi.asm.org/cgi/reprint/
71/8/5894?view=long&pmid=9223479.
Murid herpesvirus 68 (MHV-68) is an isolate of Murid her-
[2] Moon Jung Song, Seungmin Hwang, Wendy H.
pesvirus 4 which is a virus in the genus Rhadinovirus. It
Wong, Ting-Ting Wu, Sangmi Lee, Hsiang-I Liao,
is a member of the subfamily Gammaherpesvirinae in the
and Ren Sun (March 2005). "Identification of viral
family of Herpesviridae. MHV-68 serves as a model for
genes essential for replication of murine γ-
study of human gammaherpesviruses which cause signif-
herpesvirus 68 using signature-tagged
icant human disease including B-cell lymphoma and Ka-
mutagenesis". Proceedings of the National Academy of
posi’s sarcoma. The WUMS strain of MHV-68 was fully se-
Sciences of the United States of America 102 (10):
quenced and annotated in 1997 ,[1] and the necessity of
3805–10. doi:10.1073/pnas.0404521102.
most of its genes in viral replication was characterized by
http://www.pnas.org/content/102/10/
random transposon mutagenesis study .[2]
3805.abstract?ck=nck.
[3] Laurent Gillet, Janet S. May, Susanna Colaco, and
MHV-68 surface proteins Philip G. Stevenson (January 2007). "Glycoprotein L
Alpha-, beta-, and gammaherpesviruses display a het- Disruption Reveals Two Functional Forms of the
erodimer composed of glycoprotein H (gH) and glycopro- Murine Gammaherpesvirus 68 Glycoprotein H".
tein L (gL) on their envelopes. This receptor is involved Journal of Virology 81 (1): 280–291.
in the cell-to-cell transmission of the virus. Glycopro- http://jvi.asm.org/cgi/content/abstract/81/1/
tein H has two conformations. Glycoprotein L is a chap- 280.
erone protein which assures that gH takes on the correct [4] ^ Macáková K, Matis J, Rezuchová I, Kúdela O,
conformation. When herpesviruses lack gL, gH misfolds. Raslová H, Kúdelová M (Jan 2003). "Murine
When alpha- or betaherpesviruses lack gL, they are non- gammaherpesvirus (MHV) M7 gene encoding
infectious. When Murine Gammaherpesvirus 68 lacks gL, glycoprotein 150 (gp150): difference in the
it remains infectious but is less able to bind to fibroblasts sequence between 72 and 68 strains". Virus Genes 26
and epithelial cells.[3] (1): 89–95. PMID 12683351.
The open reading frame M7 of the MHV-68 genome [5] ^ James P. Stewart, Ondine J. Silvia, Isobel M. D.
encodes for the surface receptor glycoprotein 150 Atkin, David J. Hughes, Bahram Ebrahimi, and
(gp150). It is homologous to the Epstein-Barr virus mem- Heiko Adler (October 2004). "In Vivo Function of a
brane antigen gp350/220.[4] MHV-68 is more closely re- Gammaherpesvirus Virion Glycoprotein: Influence
lated to the Kaposi’s Sarcoma-associated herpesvirus on B-Cell Infection and Mononucleosis". Journal of
(KSHV) than it is to the Epstein-Barr virus. Glycoprotein Virology 78 (19): 10449–10459. http://jvi.asm.org/
K8.1 is the KSHV homolog of MHV-68 gp150.[5] MHV-68 cgi/content/full/78/19/10449.
is a very close relative of MHV-72. The MHV-68 M7 gene
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Categories:
• Herpesviruses
• Animal virology
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From Wikipedia, the free encyclopedia Murid herpesvirus 68
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