Center for Research and Integrated Development of Tropical Health
and Infectious Diseases
Volume 1, No. 1, January 2010
Division of Tropical and Infectious Disease Department of Internal Medicine
Faculty of Medicine University of Indonesia
RSUPN Cipto Mangunkusumo
Jl. Salemba Raya no,6, Jakarta
021-3908157, 3914190, Fax. 021-3911873
Center for Research and Integrated Development of Tropical Health and Infectious Disease 1
Education, through an Institution-Based also from all necessary Faculties in UI.
Competition Grant Program (Program The committee would also thank to all
Hibah Berbasis Kompetisi/ PHKI). The colleagues who work together in a team
granted fund brought an opportunity in preparing the proposal for getting the
for UI to establish a Center for Research grant.
and Integrated Development of Tropical This bulletin is presented to socialize
Health and Infectious Diseases. This the main activities as well as giving
program will be conducted in Faculty various information from the Center and
Medicine University of Indonesia. this is a real form of committee hardwork
This program is one of three finest together with staff of various department
UI internationalization program towards in FMUI. The bulletin will be published
World Class Research University quarterly and hopefully can be a media
granted by PHKI. The program of this to give information to all stakeholders of
Center includes two main activities, University of Indonesia.
Prof. dr. Djoko Widodo, SpPD, DTM&H, KPTI that is development of study group and Thank you for your attention.
Assalamu’alaikum Wr. Wb development of study program in the Wassalamualaikum Wr. Wb.
field of tropical medicine and infectious
Praise to Allah SWT for His Blessing diseases. Contribution in the form of Best Regards,
and Kindness, University of Indonesia scientific article, or other scientific
(UI) won a grant for internationalization activities that related to tropical medicine Prof. dr. Djoko Widodo, SpPD,
program from Directorate General for and infectious diseases from colleagues
Higher Education, Department of National not only from Faculty of Medicine but
FMUI Organizing Committee for PHKI
be published. This bulletin is a form coordinator of the overall PHKI activities
of existence of research centers and at FMUI, expect all academic civitas in
integrated development of tropical health University of Indonesia in general and
and infectious diseases. FMUI in particular, to be actively involved
First of all, I will give the highest in developing this integrated centers.
appreciation to the core team member My sincere hope that this newsletter
of Program Hibah Kompetisi berbasis can continue as a medium of socialization
Institusi (PHKI) UI Batch 3 that has and communication between academic
contributed their energy and ideas to civitas in the field of tropical health and
build the Research Center and Integrated infectious diseases to reify UI’s vision to
Development of Tropical Health and be the world’s class research university.
Infectious Diseases. As desired, this
dr. Pradana Soewondo, SpPD-KEMD
Research Center is aimed at improving Sincerely,
and strengthening our university to
Assalamu’alaikum Wr. Wb become an international reputation and dr. Pradana Soewondo, SpPD-KEMD
produce excellent and usefull intellectual
Thank the Almighty God, for mercy Coordinator
products to improve the welfare of the
and His grace, this first bulletin can mankind. Through this newsletter, I, as the
Diseases. I congratulate and give the teamwork to make FMUI as the center
highest appreciation to members of of learning, research, and development
Institution-Based Competition Grant of tropical health and infection which is
Program (Program Hibah Berbasis featured program on the international
Kompetisi/ PHKI) and the bulletin team network.
from Media Aesculapius of Faculty of In this first edition, I hope PHKI will
Medicine University of Indonesia (FMUI) be socialized to all FMUI civitas, therefore
for publishing this bulletin on-time. they should participate in achieving
Based on the vision of FMUI to become the objective of this program. I hope
world class Research University, FMUI has this bulletin may become a media to
the strategy to develop its main programs communicate and socialize all activities
to contribute more in the international done by PHKI. In the future, I hope this
level. That strategy is achieved through bulletin can be a media communication
PHKI which has set a program of between related parties to achieve what’s
Dr. dr. Ratna Sitompul, Sp. M(K) University Indonesia internationalization been set before.
Assalamu’alaikum Wr. Wb through the development of Center of
Research and Integrated Development of Sincerely,
First of all, I would like to thank Tropical Health and Infectious Diseases.
God for the launching of the bulletin We know that Indonesia, as a tropical Dr. dr. Ratna Sitompul, Sp. M(K)
of Center for Research and Integrated country, has a big potency to develop all Dean of FMUI
Development of Health and Infectious subjects related to tropical and infectious
diseases. Therefore, we need a great
2 Center for Research and Integrated Development of Tropical Health and Infectious Disease
INTRODUCTION of CRID-TROPHID
Center for Research and Integrated Development of
Tropical Health and Infectious Diseases
Dr. Pradana Soewondo, SpPD-KEMD
Manager of Academic and Student Affair in Faculty of Medicine University of Indonesia
E ven though with recent health
infectious disease has been
evidently the world’s health problem.
Although the technology in antibiotics
and vaccines are still being developed,
these diseases are well known to be the
cause of death and disability, social and
economic issues for millions of people.
Based on WHO’s data of Global Burden
Disease in 2004, infectious disease
contributes to the death of 16-17% of the
world’s population. departement of microbiology: laboratory
In Indonesia, according to the Basic this activity involves the development of
Health Research (Riset Kesehatan Dasar
Road map of the tropical health and information systems management and
/Riskesdas) in 2007, infectious disease
infectious diseases the dissemination of information through
was the cause of death of 28.1% from
UI’s Center for Integrated Research the media and regular seminars for the
the national mortality rate. Tuberculosis
and Development of Tropical Health and general community. This whole process
is the leading of the infectious disease
Infectious Diseases, will be developed can certainly be run by having a good
in Indonesia. Other infectious diseases,
through group activities and study of business plan.
such as liver infection, pneumonia,
tropical infectious diseases. Study group In addition to the study group, UI’s
diarrhea, malaria, typhoid fever, and
will involve various areas of expertise, Center for Research and Integrated
dengue fever also contribute to the
such as in health, science, technology, and Development of Tropical Health and
tropical infectious diseases in Indonesia.
social study. Through this study group, Infectious Diseases also want to expand
Therefore, Indonesia should take serious
UI will be expected to obtain a global research-based educational programs in
steps to address this problem.
partnership with leading institutions of tropical health and infectious diseases
University of Indonesia (UI)
tropical health and infectious diseases at an international level. This is actually
has been rec ognized nationally
in order to share knowledge, skills, and included in the vision and mission of
and internationally in the field of
facilities. Indonesia is already known, UI. Through the development of the
tropical health and infectious diseases.
as a “wealth” of diseases, must play an education system, it is expected that
Furthermore, UI has committed to more foreign students and researchers
opt to study tropical health and infectious
diseases at UI.
This educational system utilizes the
latest technology by using computer
mediated learning and distance learning
conducted by the study group. An example
of this would be the development of
module in form of credit-earning program
by granting post-graduate certificate,
post-graduate diploma, and also elective
module for graduate level. This new
system will be introduced nationally
and internationally, including the
scholarship foundation through printed
department of pediatric: laboratory and electronic media, presentations to
important role and becomes the primary potential institutions, and open house.
node cooperation network. We hope that these research
improve and strengthen its international
reputation by producing superior UI will develop a based-community centers, study groups, and all the
intellectual products that will be useful laboratory for the infectious disease. planned programs can further confirm
for improving the welfare of mankind. UI will also map the potential resources University of Indonesia as a world class
To achieve these goals, UI will develop that are associated with tropical research university. A good business
a Center for Research and Integrated health and infectious diseases in its plan will support the implementation
Development of Tropical Health and environment. This study group will then of all activities in reaching the target.
Infectious Diseases be introduced and formed alliance with Everyone’s support is required for the
international parties. Other than that, success of this program.
Center for Research and Integrated Development of Tropical Health and Infectious Disease 3
INTRODUCTION of CRID-TROPHID
Organization Structure of Center for Research and Integrated
Development of Tropical Health and Infectious Disease
Daily Executive Board
Executive Board Secretariat
Director of Activities I I
Director of Activities Director Activities
Director of ActivitiesIIII
(Head of Tropical InfectionDivision)
(Head of Tropical Infection Division) (Head of Biomedic Study Programme)
(Head of Biomedic Study Programme)
Coordinator of Coordinator of Database and
Coordinator of Database and Coordinator of Undergraduate
Undergraduate Post Graduate
(dr. Anis) (dr. Leo) (dr. Muchtar)
ThematicTeam Thematic Team
of Infectious of Tropical
1. Team of Proposal Completion of PHKI FMUI 2010 2. Committee of Formation of Center for Research and
based on ST Dean of FMUI no: 931/ST/D/FKUI/2008 Integrated Development of Tropical Health and
• dr. Pradana Soewondo, SpPD-KEMD Infectious Disease in the framework of PHKI 2010
• Prof. dr. Djoko Widodo, SpPD-KPTI based on ST Dean of FMUI no: 932/ST/D/FKUI/2009
• dr.rer. Physiol. Septelia Inawati Wanandi • dr. Pradana Soewondo, SpPD-KEMD
• dr. Leonard Nainggolan, SpPD-KPTI • Prof. dr. Djoko Widodo, SpPD-KPTI
• dr. Anis Karuniawati, PhD, SpMK (K) • Dr. dr. Suhendro, SpPD-KPTI
• Dr. dra. Taniawati Supali • dr.rer. Physiol. Septelia Inawati Wanandi
• dr. Muchtaruddin Mansyur, PhD, SpOk • dr. Leonard Nainggolan, SpPD-KPTI
• dr. Indah Suci Widyahening, MSc • dr. Anis Karuniawati, PhD, SpMK (K)
• dr. Eva Suarthana, PhD • Dr. dra. Taniawati Supali
• dr. Muchtaruddin Mansyur, PhD, SpOk
• dr. Indah Suci Widyahening, MSc
• dr. Widayat Djoko, SpPD-KPTI
4 Center for Research and Integrated Development of Tropical Health and Infectious Disease
A Key to Success in Research
development of research in Indonesia.
Through this program, infectious diseases
study in Indonesia can be improved.
An example of program that has been
conducted is research about dengue
high fever. The research covers 6 areas in
clinical practice: internal medicine, clinical
pathology, microbiology, community
medicine, paediatrics , and parasitology.
“Networking program is not only
about integrated inter-departmental
cooperation in FMUI, but also will develop
into interfaculty level, among universities,
and hopefully among countries,” said dr.
Leonard. He admitted that until today
there are some researches performed
with international collaboration such
as Fever Study Group. In addition, this
programme is emphasizing not only the
research aspect, but also the exchange of
students between countries.” We expect
the results of networking program which
R esearch of infectious disease grows the Ministry of Education. Having been involves the entire aspects can achieve
rapidly including in Indonesia. reviewed, by the Ministry of Education, high quality result in order to support the
As a tropical country, this field the proposal was decided to be examined health development in Indonesia, such as
of research is very important due to in the system. The funding of support the the discovery of H5N1 virus vaccine and
high prevalence of infectious diseases. networking research program in tropical- cure for many infectious diseases,” said
Indonesia itself is a repository of disease infection is approximately 2 billion dr. Leonard.
vectors. Many illnesses are typical in this Rupiah per year. This fund will last for 3 This program offers new hope for the
country, but unfortunately not all of them
have been studied.
Research of infectious disease in
Indonesia gains particular attention
in national and international level. In
infectious disease research, review from
only one science field is not enough. It
is necessary to integrate several related
fields, which is aimed to understand the
intricacies of the disease being studied.
However, one big question revealed
about how to integrate several different
disciplines in examining a disease. The
answer purposed is networking program.
This program is quite new in Indonesia
but it has been implemented for a long time
in other countries. Networking program
is an integrated program involving several
disciplines to review an issue. According
to dr. Leonard Nainggolan, SpPD-KPTI,
the idea to implement this system was
declared in 2008 by several doctors in
FMUI who intrigued with the concept
of inter-department research. This idea
years starting from 2010. It is estimated improvement of health in this country, a
was then proposed by FMUI to the UI
that within 3 years, this program can get new hope for Indonesia.
level, especially regarding the existence
of research centers of infectious tropical financial support independently.
diseases. At the UI level, the concept was Networking program provides
embodied in the form of proposals to a conducive atmosphere for the
Center for Research and Integrated Development of Tropical Health and Infectious Disease 5
Division of Tropical and Infectious Disease:
Education, Research, and Public Service in Infectious Disease
A s a part of Department of Internal
Medicine, Division of Tropical and
Infectious Disease Faculty of Medicine
measurement of tissue oxygenation
in severe infection, and Side stream
Dark Field (SDF) for a bedside real time
University of Indonesia (FMUI) has a imaging of detail microvascularization in
vision to become a well known center of severe infection.
infectious diseases in Asia Pacific in 2010 Various researches include A
and capable to cope with education, Prospective Multinational Surveillance
research, and public service demands with of Hospital Acquired Pneumonia (HAP)
humanistic approach. The Educational and Ventilator-associated Pneumonia
program of tropical health and infectious (VAP) in Adults in Asian Countries:
diseases is held for those who will Etiology, Clinical Outcome, and Impact
become internist or consultant. The of Antimicrobial Resistance which has
division also concerns about education been done completely and others, such
for paramedics and public. The program as Effectivity and Safety of Lactobacillus
is given in various ways according to their reuteri Usage in Prevention of Antibiotic
level. Associated Diarrhea and Clostridium
The division always tries to hold difficile Associated Infections in
researches according to the development Hospitalized Adult Patients which is still
of tropical and infectious diseases in progress.
knowledge as well as public concern. The public services are given through
The topic includes clinical epidemiology, polyclinic and inpatient ward. In order
and drug clinical trials in the field of to increase the public services, Center of
tropical health and infectious diseases. Infectious Disease is now being settled.
Diagnostic means for infectious diseases In the future, the center hopefully could
were also included in the topics, for give high quality services in the field of
example: Transcutaneous Monitoring tropical health and infectious diseases.
System (Novametrix®) for time to time
Department of Paediatric:
Pillar for The National Children Health Improvement
A s one of the major departments in
Faculty of Medicine University of
Indonesia (FMUI)-Cipto Mangunkusumo
Furthermore, there are many others
ongoing research themes, some of them
are The Systemic Mycosis in Malignancy,
National Hospital, Department of Role of CRP and Procalcitonin in Septic
Paediatric always applies the Tri Diagnostics in Children, and others
Dharma:education, public service, and researches. Besides the themes above,
research. In terms of education, this there are also other studies with various
department continuously improves the topics such as HIV, antimicrobial resistance,
quality of its graduates through a new and Streptococcus pneumonia.
medical school curriculum commonly To support all of the researches,
called Kurfak 2005. Department of Paediatric provides
This department also contributes a an integrated laboratory supported
lot in community service. There have by technology and competent human
been many medical staffs sent by the resources incorporated called the
department to work at the site of disaster Paediatric Research Unit. This team’s
and remote area. job are gathering people who have good
The Department of Paediatric is also research ideas, collecting laboratory and
actively conducts research projects. An field workers, and fundraising either from
example of research topic that gains grant or research competition.
particular attention is tropical health and Establishment of Paediatric Research
infectious diseases. Currently, several Unit is a way to achieve the vision of
studies are ongoing in this department. the Department of Paediatric to be a
In relation to the topic of fever, there hospital which performs public service,
has been an ongoing study named Fever research, and education. The existence
with Unknown Causes in Children 0-36 of Paediatric Research unit is expected
months. to be the primary support for improving
children health quality in Indonesia.
6 Center for Research and Integrated Development of Tropical Health and Infectious Disease
ARTICLES Exploring the Micro-Study in
Department of Microbiology FMUI
D epartment of Microbiology Faculty
of Medicine University of Indonesia
(Micro-FMUI) is recognized as an
Antimicrobial susceptibility in patterns.
Beside that, Micro-UI has planned
several researches which will be started
outstanding department in terms of in 2010 based on ‘the research tree’.
institutional research facilities and high- The titles of these researches are: Fever
qualified scientists. Not only specialized in study, Development of Dengue Vaccine,
clinical microbiology, this department also Selection and Production of Anti-
works in medically related environmental dengue Antibody Producing Hybridoma
microbiology and surveillance study for The Development of Dengue
on various kinds of infectious disease Diagnostic Reagent, Identification and
which has become a major public health Characterization of The Bacteria Causing
problems in Indonesia. Acute Otitis Media Episodes in Young
Micro-FMUI has responsibility for Children, Development of In-House Anti-
education, research, and public services retroviral Drug Resistance Test, and other
in the field of microbiology. Educational researches.
activities for undergraduate students Public services provided by
include basic clinical microbiology for Micro-UI include microbiology diagnostic
medical student and health science test to identify and characterize etiologic
student. Furthermore Micro-UI provides agents from clinical specimens, as
education for master degree on well as antibiotics susceptibility test,
biomedical sciences, medical specialist supporting infection control in hospitals,
in clinical microbiology and research for and consultation on clinical microbiology.
biomedical and medical PhD program in Additionally, Micro-UI has been chosen by
FMUI. Ministry of Health Republic of Indonesia
Micro-UI is also active in conducting as The National Referral Laboratory
research projects. In 2009, Micro-UI for M.tuberculosis (culture and direct
published some research reports with antimicrobial susceptibility test) and
the topic of Dengue Virus, Bacillus The National Referral Laboratory for
subtilis profile of vaginal flora and Antiretroviral (HIV-1) resistance test.
acidity of Indonesian Women, and Existing facilities are being used and
developed for these purpose.
Community-Based Research in
Department of Parasitology
D epartment of Parasitology Faculty
of Medicine University of Indonesia
is one of the most focusing to perform
several international agencies.
Collaborating with LUMC, another
community-based research was
research on parasitic diseases. It has performed in Ende district, ENT in 2006.
several research-projects with foreign The study focuses on parasitic infection
partners, such as Leiden University (intestinal helminth and malaria) and
Medical Center (LUMC); Washington inflammatory diseases. A good effort in
University, Saint Louis, USA; Edinburgh database has been started by mapping of
University, United Kingdom; Bernhard the study area using global positioning
Nocht Institute for Tropical Medicine, system technology. This tool updates
Hamburg, Germany; Bill Gate and Melinda resident movement via monthly follow
Foundation and Germany Agency for up performed by cadres. The cadres are
Technical Co-operation (GTZ-SiSKES), local people who have been trained to
Germany. record the people movement.
In 2000, a research area in Alor district, This department also contributes
East Nusa Tenggara (ENT) focusing to increase the health quality of native
for Filariasis elimination program was people who participated as research
established. The aim of the study is to subjects and cadres of health department
eliminate filariasis due to specific filarial and community health service. They
parasite in Indonesia, Brugia timori, have been regularly informed about
by mass drug administration to whole the result of the study on malaria and
population. Until this time on, the stool examinations, blood analysis, and
research area has been being maintained other measurements. Currently, Ende
for almost ten years in order to evaluate district has been chosen as an area for
the target achievements. Furthermore, community-based research for PHKI.
this study gets funding support from
Center for Research and Integrated Development of Tropical Health and Infectious Disease 7
Knowing The Virology Study and Research in IHVCB-UI
tools based on Indonesian strains, IHVCB-UI is supported with biosafety level
development of antiretroviral drug 2 and 3 (BSL-2 and BSL-3) laboratories, cell
resistance testing both genotyping culturing room, polymerase chain reaction
and phenotyping, and development (PCR) facilities, protemic machine, and
of antiretroviral drug and vaccines. genetic engineering and transfection.
IHVCB-UI is the first institute BSL2 and BSL3 laboratories have been
which has successfully cultured certified by World BioHaztec Inc., an
avian influenza virus. The study is international company from United
related to diagnostic kit and vaccines States. In the future, we plan IHVCB-UI
development included polyclonal to become the centre of excellence for
and monoclonal antibodies against virological research in Indonesia. We hope
H5N1, and recombinant viral that health development in Indonesia will
R eseach is a basic thing and it becomes
a focus of University of Indonesia (UI).
IHVCB-UI is established with international
proteins production. Prototype
Vaccines for H5N1 have been obtained,
and DNA and virus like-particles
be improved and more independent”, dr.
Fera closing with smile.
standard as a supporting unit. Through (VLP) vaccines have been produced
research, hopefully it will realize the vision by IHVCB-UI.
of University of Indonesia as a world class The researches of HPV
research university,” says dr. Fera Ibrahim, include mapping of cervix
MSc, SpMK(K), PhD, director of science. cancer in Indonesia by molecular
Researches in IHVCB-UI are related to epidemiology study and
virological studies with four main focus: development of diagnostic
HIV, avian influenza virus (AIV), influenza tools, preventive, and curative
virus, and human papilloma virus (HPV). vaccines.
Researches on HIV include detection “IHVCB-UI was founded in
and isolation of HIV, mapping of HIV in 2004, but we actively conduct
Indonesia, development of diagnostic research since July 2007. Now
Department of Community Medicine FMUI:
Pioneer in Community-Based Medicine
T he Department of Community-,
Occupational-, and Family Medicine
(COF Depart.) or Departemen Ilmu
Urban Setting, in collaboration with the
Global Fund. Another study that has just
started is a multidepartmental study
Kedokteran Komunitas, Okupasi dan focuses on exploring the etiology of fever
Keluarga (Dep. KKOK) is one of the major in the community. By collaborating with
departments at the Faculty of Medicine the Slotervaart Hospital Amsterdam, this
University of Indonesia (FMUI) which is study will evaluate the diagnostic value of
responsible for conducting education, certain markers in establishing diagnosis
research and services in the field of rapidly and accurately.
community medicine. This department provides educations
This department has conducted many for undergraduate and postgraduate
community-based studies including students. The undergraduate students are
infectious disease related studies, such introduced to holistic and comprehensive three months courses of the Third
as the efficacy of influenza immunization patient management that considers the Country Training Program in Community
program at the workplace. It also has influencing factors of health, including Medicine, which also consists of emerging
an ongoing research projects titled genetic, environment, behavior, and and reemerging infectious disease
Enhancing Tuberculosis Programme in social. At post graduate level, the training management modules. Until this time
and education expose the students to the on, this program has trained two groups
community’s perspective of infectious of trainee doctors from Afghanistan.
diseases and tropical medicine. Through some of its facilities, the COF
The COF department also has department provides health services
significant contributions at international at regular basis through their health
level. In 2009, two foreign students from centers/family medicine clinics in Kiara
John Hopkins University and University and Kayuputih. Health services in other
of Amsterdam joined this department public health centres is also performed.
and studied HIV/AIDS and leptospirosis, These health centers also serve as
respectively. This department is also laboratory health services, research, and
trusted by the Japan International education on infectious diseases and
Cooperation Agency (JICA) to conduct tropical medicines for the community.
8 Center for Research and Integrated Development of Tropical Health and Infectious Disease