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Carrying on the tradition of world-changing innovation 2007

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					                             2007 Technology Transfer Awards




Carrying on the tradition of world-changing innovation
             E   N T OF
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                                       Los Alamos National Laboratory, an affirmative action/equal opportunity
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                                       employer, is operated by Los Alamos National Security, LLC, for the
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                                       National Nuclear Security Administration of the U.S.Department of
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          ST                A
               AT E S O F              Energy under contract DE-AC52-06NA25396. Reference herein to
                                       any specific commercial product, process, or service by trade name,
                                       trademark, manufacturer, or otherwise does not necessarily constitute
                                       or imply its endorsement, recommendation, or favoring by the
                                       Los Alamos National Security, LLC, the U.S. Government, or any
                                       agency thereof. The views and opinions of authors expressed herein
                                       do not necessarily state or reflect those of Los Alamos National
                                       Security, LLC, the U.S. Government, or any agency thereof.
               2007 Technology Transfer Awards


Carrying on the tradition of world-changing innovation
                   Thursday, May 29, 2008
               Los Alamos National Laboratory
                  Los Alamos, New Mexico




                                                         iii
iv
Outstanding Innovation                                                         Los Alamos National Laboratory



                                  W       elcome to the tenth Annual Technology Transfer Awards
                                          Reception. This evening is a celebration of Los Alamos
                                  National Laboratory’s innovators and recognition of their vital role
                                  in transferring state-of-the-art technologies from the Laboratory to
                                  the private sector.

                                  According to the Department of Energy, estimates are that half
                                  the growth in the U.S. economy over the past 50 years resulted
                                  from funding for scientific and technological innovation. DOE’s
                                  investments have increased intellectual capital, advanced medical
                                  and health care needs, enhanced economic competitiveness, and
                                  improved the quality of life of the American people.

                                  Many of these scientific breakthroughs have come directly from Los
                                  Alamos National Laboratory. I am proud to honor our Laboratory
                                  innovators for their outstanding efforts in creating, protecting,
                                  licensing, and working with industry and academia to achieve such
                                  impressive collaborations and advances in science.

                                  On behalf of the senior management team and the entire
                                  Laboratory community, I extend congratulations and appreciation
                                  to this evening’s honorees for their achievements. And I encourage
                                  ongoing participation by all Laboratory innovators in technology
                                  transfer activities. It is this partnership with the business
                                  community that will allow Los Alamos National Laboratory
                                  to continue its vital role in regional and national economic
                                  competitiveness for decades to come.




                                                           Michael R. Anastasio
                                                           Laboratory Director




2007 Technology Transfer Awards                                                                            1
Los Alamos National Laboratory                                                       Outstanding Innovation


                                 Keynote Speaker: Manual E. Gonzalez
                                 Chevron Energy Technology Company
                                 As Chevron’s manager for the Advanced Energy Solutions Alliance
                                 with the Laboratory, Manuel (Manny) Gonzalez brings more than
                                 a quarter century of experience with oil exploration and technol-
                                 ogy transfer to the job. Gonzalez’s expertise in technology transfer
                                 goes back to the early 1980s when he worked with both NASA
                                 and LANL to bring advances to the oil industry, including a high
                                 temperature insulating technology developed with LANL —an
                                 innovation that saved over $300,000 per well. In the 1990s, Gonza-
                                 lez founded a company named Isotag Inc. (now called Authentix)
                                 based on a LANL technology for molecular marking of liquids.
                                 Isotag became the first U.S. company to receive Germany’s Interna-
                                 tional Jurgen Schnider Technology Award for the “Highest Innova-
                                 tive and Technological Achievement” and was recently acquired by
                                 The Carlyle Group. The company is credited with recovering more
                                 than $5 billion in lost revenue for its clients by preventing fraudu-
                                 lent adulteration of products from gasoline to pharmaceuticals.
                                 In addition to helping to transfer technologies from the laboratory
                                 to industry, Gonzalez holds 21 U.S. and international patents with
                                 many of these licensed to the oil industry. Gonzalez also has pub-
                                 lished widely in numerous technical journals, served on several
                                 committees for national technical organizations, been quoted by the
                                 Wall Street Journal and Business Week, and testified to the National
                                 Academy of Sciences on technology transfer. All of this follows a
                                 distinguished military career recognized with numerous medals.
                                 Gonzalez currently leads the Chevron-LANL research alliance,
                                 overseeing a diverse array of projects with impact on multiple
                                 aspects of the oil industry from deepwater drilling to refining. Gon-
                                 zalez brings an ability to rapidly and effectively connect technology
                                 to industry-critical problems, concurrently advancing the state of
                                 the art while improving profitability.




2                                                                            2007 Technology Transfer Awards
Outstanding Innovation                                                                   Los Alamos National Laboratory


Abstracts of Issued                     Preparation of High Nitrogen           chromic devices with nanostruc-
                                        Compound and Material                  tured electrodes include ionic
Patents                                                                        liquids with bifunctional
                                        Therefrom
Listings are in accordance with issue                                          redox dyes.
dates from beginning to end of fiscal   My Hang V. Huynh (DE-1)
year 2007                               Michael A. Hiskey (DE-1)               Photoinduced Charge-
                                        U.S. Patent 7,119,179
                                                                               Transfer Materials
                                        The high-nitrogen compound of          for Nonlinear Optical
                                        the formula ##STR00001## was
                                                                               Applications
                                        prepared. Pyrolysis of the com-
                                        pound yields carbon nitrides C2N3      Duncan W. McBranch (PADSTE)
                                        and C3N5. The carbon nitrides vary     U.S. Patent 7,125,578
                                        in their density, texture, and mor-    A method using polyelectrolyte
                                        phology.                               self-assembly for preparing multi-
                                                                               layered organic molecular materi-
                                        Durable Electrooptic Devices           als having individual layers which
                                        Comprising Ionic Liquids               exhibit ultrafast electron and/
                                                                               or energy transfer in a controlled
                                        Benjamin P. Warner (MPA-MC)            direction occurring over the entire
                                        Thomas M. McCleskey (MPA-MC)           structure. Using a high molecular
                                        Anthony K. Burrell (MPA-MC)            weight, water-soluble, anionic form
                                        U.S. Patent 7,119,937                  of polyphenylene vinylene (PPV),
                                        Electrolyte solutions for electro-     self-assembled films can be formed
                                        chromic devices such as rear view      which show high photolumines-
                                        mirrors and displays with low          cence quantum efficiency (QE). The
                                        leakage currents are prepared          highest emission QE is achieved
                                        using inexpensive, low conductiv-      using poly(propylene-imine) (PPI)
                                        ity conductors. Preferred electro-     dendrimers as cationic binders.
                                        lytes include bifunctional redox       Self-quenching of the luminescence
                                        dyes and molten salt solvents with     is observed as the solid polymer
                                        enhanced stability toward ultravio-    film thickness is increased and can
                                        let radiation. The solvents include    be reversed by inserting additional
                                        lithium or quaternary ammonium         spacer layers of transparent poly-
                                        cations and perfluorinated sul-        electrolytes between each active
                                        fonylimide anions selected from        conjugated layer, such that the QE
                                        trifluoromethylsulfonate (CF3SO3-),    grows with thickness. A red shift of
                                        bis(trifluoromethylsulfonyl)           the luminescence is also observed
                                        imide ((CF3SO2)2N-),                   as additional PPV layers are added.
                                        bis(perfluoroethylsulfonyl)            This effect persists as self-quenching
                                        imide ((CF3CF2SO2)2N-) and             is eliminated. Charge transfer
                                        tris(trifluoromethylsulfonyl)methide   superlattices can be formed by
                                        ((CF3SO2)3C-). Electroluminescent,     additionally incorporating C60
                                        electrochromic and photoelectro-       acceptor layers.

2007 Technology Transfer Awards                                                                                      3
Los Alamos National Laboratory                                                                   Outstanding Innovation


Stable Isotope, Site-Specific           and will significantly increase data     Quantitative Method of
Mass Tagging for Protein                search specificity, efficiency and       Determining Beryllium or
Identification                          accuracy for protein identifications.    a Compound Thereof in a
Xian Chen (B-2)
                                                                                 Sample
                                        Vectorized Image
U.S. Patent 7,125,685                                                            T. Mark McCleskey (MPA-MC)
                                        Segmentation via Trixel
Proteolytic peptide mass mapping                                                 Deborah S. Ehler (MPA-MC)
                                        Agglomeration                            Kevin D. John (C-IIAC)
as measured by mass spectrometry
provides an important method for        Lakshman Prasad (ISR-2)                  Anthony K. Burrell (MPA-MC)
the identification of proteins, which   Alexei N. Skourikhine (ISR-2)            Gavin E. Collis (C-SIC)
are usually identified by matching      U.S. Patent 7,127,104                    Edel M. Minogue (C-ADI)
the measured and calculated m/z         A computer implemented method            Benjamin P. Warner (MPA-MC)
values of the proteolytic peptides.     transforms an image comprised            U.S. Patent 7,129,093
A unique identification is, however,    of pixels into a vectorized image        A method of determining beryllium
heavily dependent upon the mass         specified by a plurality of polygons     or a beryllium compound thereof
accuracy and sequence coverage          that can be subsequently used to aid     in a sample, includes providing a
of the fragment ions generated by       in image processing and under-           sample suspected of comprising
peptide ionization. The present         standing. The pixelated image is         beryllium or a compound thereof,
invention describes a method for        processed to extract edge pixels         extracting beryllium or a com-
increasing the specificity, accuracy    that separate different colors and a     pound thereof from the sample by
and efficiency of the assignments of    constrained Delaunay triangulation       dissolving in a solution, adding a
particular proteolytic peptides and     of the edge pixels forms a plurality     fluorescent indicator to the solution
consequent protein identification by    of triangles having edges that cover     to thereby bind any beryllium or a
the incorporation of selected amino     the pixelated image. A color for each    compound thereof to the fluorescent
acid residue(s) enriched with stable    one of the plurality of triangles is     indicator, and determining the pres-
isotope(s) into the protein sequence    determined from the color pixels         ence or amount of any beryllium or
without the need for ultrahigh          within each triangle. A filter is        a compound thereof in the sample
instrumental accuracy. Selected         formed with a set of grouping rules      by measuring fluorescence.
amino acid(s) are labeled with          related to features of the pixelated
13   15    2
   C/ N/ H and incorporated into        image and applied to the plurality       Buffer Layer for Thin Film
proteins in a sequence-specific man-    of triangle edges to merge adjacent      Structures
ner during cell culturing. Each of      triangles consistent with the filter
these labeled amino acids carries a     into polygons having a plurality of      Stephen R. Foltyn (MPA-STC)
defined mass change encoded in its      vertices. The pixelated image may        Quanxi Jia (MPA-STC)
monoisotopic distribution pattern.      be then reformed into an array of        Paul N. Arendt (MPA-STC)
Through their characteristic pat-       the polygons that can be repre-          Haiyan Wang (MPA-STC)
terns, the peptides with mass tag(s)    sented collectively and efficiently by   U.S. Patent 7,129,196
can then be readily distinguished       standard vector image.                   A composite structure including
from other peptides in mass spectra.                                             a base substrate and a layer of a
The present method of identify-                                                  mixture of strontium titanate and
ing unique proteins can also be                                                  strontium ruthenate is provided. A
extended to protein complexes                                                    superconducting article can include
                                                                                 a composite structure including
4                                                                                        2007 Technology Transfer Awards
Outstanding Innovation                                                                     Los Alamos National Laboratory

an outermost layer of magnesium         molecule material and at least one        Method to Amplify Variable
oxide, a buffer layer of strontium      of the one or more ligands.               Sequences without Imposing
titanate or a mixture of strontium                                                Primer Sequences
titanate and strontium ruthenate        Magnetic Infrasound Sensor
and a top layer of a superconduct-                                                andrew M. Bradbury (B-9)
ing material such as YBCO upon the      Frederick M. Mueller (MPA-STC)            Ahmet Zeytun (B-7)
buffer layer.                           Lawrence E. Bronisz (IAT-2)               U.S. Patent 7,135,310
                                        Holger Grube (MST-8)                      The present invention provides
                                        David C. Nelson (AET-5)
High Throughput Screening                                                         methods of amplifying target
                                        Jonathan L. Mace (DE-6)                   sequences without including regions
of Ligand Binding to                    U.S. Patent 7,134,342
Macromolecules using                                                              flanking the target sequence in the
                                        A magnetic infrasound sensor is           amplified product or imposing
High Resolution Powder                  produced by constraining a per-           amplification primer sequences on
Diffraction                             manent magnet inside a magnetic           the amplified product. Also pro-
Robert B. Von Dreele (LANSCE)           potential well above the surface          vided are methods of preparing a
U.S. Patent 7,130,747                   of superconducting material. The          library from such amplified target
                                        magnetic infrasound sensor mea-           sequences.
A process is provided for the high      sures the position or movement of
throughput screening of binding of      the permanent magnet within the
ligands to macromolecules using                                                   Functionalized Polymers
                                        magnetic potential well, and inter-
high resolution powder diffraction      prets the measurements. Infrasound
                                                                                  for Binding to Solutes in
data including producing a first        sources can be located and charac-        Aqueous Solutions
sample slurry of a selected poly-       terized by combining the measure-
crystalline macromolecule material                                                Barbara F. Smith (C-CSE)
                                        ments from one or more infrasound         Thomas W. Robison (C-CSE)
and a solvent; producing a second       sensors. The magnetic infrasound
sample slurry of a selected poly-                                                 U.S. Patent 7,138,462
                                        sensor can be tuned to match infra-
crystalline macromolecule material,                                               A functionalized polymer for bind-
                                        sound source types, resulting in bet-
one or more ligands and the solvent;                                              ing a dissolved molecule in an
                                        ter signal-to-noise ratio. The present
obtaining a high resolution powder                                                aqueous solution is presented. The
                                        invention can operate in frequency
diffraction pattern on each of said                                               polymer has a backbone polymer to
                                        modulation mode to improve sensi-
first sample slurry and the second                                                which one or more functional groups
                                        tivity and signal-to-noise ratio. In an
sample slurry; and comparing the                                                  are covalently linked. The backbone
                                        alternate construction, the super-
high resolution powder diffraction                                                polymer can be such polymers as
                                        conductor can be levitated over a
pattern of the first sample slurry                                                polyethylenimine, polyvinylamine,
                                        magnet or magnets. The system can
and the high resolution powder                                                    polyallylamine, and polypropylam-
                                        also be driven, so that time-resolved
diffraction pattern of the second                                                 ine. These polymers are generally
                                        perturbations are sensed, resulting
sample slurry whereby a difference                                                water-soluble but can be insoluble
                                        in a frequency modulation Ver-
in the high resolution powder dif-                                                when cross-linked. The functional
                                        sion with improved sensitivity and
fraction patterns of the first sample                                             group can be, for example, diol
                                        signal-to-noise ratio.
slurry and the second sample slurry                                               derivatives, polyol derivatives, thiol
provides a positive indication for                                                and dithiol derivatives, guest-host
the formation of a complex between                                                groups, affinity groups, beta-diphos-
the selected polycrystalline macro-                                               phonic acids, and beta-diamides


2007 Technology Transfer Awards                                                                                        5
Los Alamos National Laboratory                                                                      Outstanding Innovation


Preparation of Nanoporous                 with a polymer binder. The binder is      tor nanocrystals including a Group
Metal Foam from High                      transparent to the scintillator emis-     II VI compound, the nanocrystals
Nitrogen Transition Metal                 sion. The composite is seamless and       being distributed in a metal oxide
                                          can be made large and in a wide           matrix. The grating can have a peri-
Complexes                                 variety of shapes. Importantly, the       odicity from 200 nm to 500 nm.
Bryce C. Tappan (DE-6)                    composite can be tailored to emit
My Hang V. Huynh (DE-1)                   light in a spectral region that matches   Continuous Equal Channel
Michael A. Hiskey (DE-1)                  the optimum response of photomul-
                                                                                    Angular Pressing
Steven F. Son (DE-6)                      tipliers (about 400 nanometers) or
David M. Oschwald (DE-6)                  photodiodes (about 600 nanometers),       Yuntian T. Zhu (MPA-STC)
David E. Chavez (DE-1)                    which maximizes the overall detector      Terry C. Lowe (CAO-AM)
Darren L. Naud (DE-1)                     efficiency.                               U.S. Patent 7,152,448
U.S. Patent 7,141,675                                                               An apparatus that continuously
Nanoporous metal foams are                Through-the-Earth Radio                   processes a metal workpiece with-
prepared by ignition of high                                                        out substantially altering its cross
                                          David W. Reagor (MPA-STC)
nitrogen transition metal com-                                                      section includes a wheel member
                                          Jose Vasquez-Dominquez (MPA-STC)
plexes. The ammonium salts of                                                       having an endless circumferential
                                          U.S. Patent 7,149,472
iron(III) tris[bi(tetrazolato)-amine],                                              groove and a stationary constraint
cobalt(III) tris[bi(tetrazolato)amine],   A through-the-earth communication         die that surrounds the wheel mem-
and high nitrogen compounds of            system that includes a digital signal     ber, covers most of the length of the
copper and silver were prepared as        input device; a transmitter operating     groove, and forms a passageway
loose powders, pressed into pellets       at a predetermined frequency suf-         with the groove. The passageway
and wafers, and ignited under an          ficiently low to effectively penetrate    has a rectangular shaped cross sec-
inert atmosphere to form nanopo-          useful distances through-the earth;       tion. An abutment member projects
rous metal foam monoliths having          a data compression circuit that is        from the die into the groove and
very high surface area and very           connected to an encoding processor;       blocks one end of the passageway.
low density.                              an amplifier that receives encoded        The wheel member rotates relative
                                          output from the encoding processor        to the die in the direction toward the
                                          for amplifying the output and trans-      abutment member. An output chan-
Flexible Composite                        mitting the data to an antenna; and       nel in the die adjacent the abutment
Radiation Detector                        a receiver with an antenna, a band        member has substantially the same
David W. Cooke (MST-8)                    pass filter, a decoding processor, and    cross section as the passageway. A
Bryan L. Bennett (MST-8)                  a data decompressor.                      metal workpiece is fed through an
Ross E. Muenchausen (MST-8)                                                         input channel into the passageway
Debra A. Wrobleski (MST-7)                Nanocrystal Structures                    and carried in the groove by fric-
Edward B. orler (MST-7)                                                             tional drag in the direction towards
U.S. Patent 7,145,149                     Victor I. Klimov (C-PCS)                  the abutment member, and is
                                          U.S. Patent 7,150,910                     extruded through the output chan-
A flexible composite scintillator was
                                          A structure including a grating and       nel without any substantial change
prepared by mixing fast, bright,
                                          a semiconductor nanocrystal layer         in cross section.
dense, rare-earth doped powdered
oxyorthosilicate (such as LSO:Ce,         on the grating can be a laser. The
LSO:Sm, and GSO:Ce) scintillator          semiconductor nanocrystal layer can
                                          include a plurality of semiconduc-

6                                                                                           2007 Technology Transfer Awards
Outstanding Innovation                                                                    Los Alamos National Laboratory

Magnetic Process for                     heavy metals from water using the       oligonucleotide complex is formed
Removing Heavy Metals                    process outlined above.                 but not when the oligonucleotide
from Water Employing                                                             complex is not formed. The presence
                                         Immunogenic Peptides                    or absence of the specific amplicon
Magnetites                                                                       is used to detect the allele. Detec-
                                         Comprising a T-helper
F. Coyne Prenger (AET-1)                                                         tion of the specific amplicon may be
                                         Epitope and a B-cell                    achieved using a variety of methods
Dallas D. Hill (AET-1)
U.S. Patent 7,153,435                    Neutralizing Antibody                   well known in the art, including,
                                         Epitope                                 without limitation, oligonucleotide
A process for removing heavy
                                                                                 capture onto DNA chips or microar-
metals from water is provided.           Bette T. M. Korber (T-10)
                                                                                 rays, oligonucleotide capture onto
The process includes the steps of        U.S. Patent 7,153,509
                                                                                 beads or microspheres, electrophore-
introducing magnetite to a quantity      The present invention relates, gener-   sis, and mass spectrometry. Various
of water containing heavy metal.         ally, to a polyvalent immunogen         labels and address-capture tags may
The magnetite is mixed with the          and, more particularly, to a method     be employed in the amplicon detec-
water such that at least a portion       of inducing neutralizing antibod-       tion step of multiplexed assays, as
of, and preferably the majority of,      ies against HIV and to a polyvalent     further described herein.
the heavy metal in the water is          immunogen suitable for use in such
bound to the magnetite. Once this        a method.
occurs the magnetite and absorbed                                                Method of Transferring a Thin
metal is removed from the water                                                  Crystalline Semiconductor
by application of a magnetic field.      Nucleic Acid Sequence
                                                                                 Layer
In most applications the process         Detection Using Multiplexed
is achieved by flowing the water         Oligonucleotide PCR                     Michael A. Nastasi (MPA-CINT)
through a solid magnetized matrix,                                               Lin Shao (MPA-CINT)
                                         John P. Nolan (B-5)                     U.S. Patent 7,153,761
such as steel wool, such that the
                                         P. Scott White (B-7)
magnetite magnetically binds to the                                              A method for transferring a thin
                                         U.S. Patent 7,153,656
solid matrix. The magnetized matrix                                              semiconductor layer from one sub-
preferably has remnant magne-            Methods for rapidly detecting single    strate to another substrate involves
tism, but may also be subject to an      or multiple sequence alleles in a       depositing a thin epitaxial monocrys-
externally applied magnetic field.       sample nucleic acid are described.      talline semiconductor layer on a
Once the magnetite and associated        Provided are all of the oligonucle-     substrate having surface contami-
heavy metal is bound to the matrix,      otide pairs capable of annealing        nants. An interface that includes the
it can be removed and disposed of,       specifically to a target allele and     contaminants is formed in between
such as by reverse water or air and      discriminating among possible           the deposited layer and the substrate.
water flow through the matrix. The       sequences thereof, and ligating to      Hydrogen atoms are introduced into
magnetite may be formed in situ          each other to form an oligonucle-       the structure and allowed to diffuse
by the addition of the necessary         otide complex when a particular         to the interface. Afterward, the thin
quantities of Fe(II) and Fe(III) ions,   sequence feature is present (or,        semiconductor layer is bonded to a
or pre-formed magnetite may be           alternatively, absent) in the sample    second substrate and the thin layer
added, or a combination of seed and      nucleic acid. The design of each oli-   is separated away at the interface,
in situ formation may be used. The       gonucleotide pair permits the subse-    which results in transferring the thin
invention also relates to an appara-     quent high-level PCR amplification      epitaxial semiconductor layer from
tus for performing the removal of        of a specific amplicon when the         one substrate to the other substrate.

2007 Technology Transfer Awards                                                                                       7
Los Alamos National Laboratory                                                                     Outstanding Innovation


Handheld Isotope                         regions to a correlation coefficient of   Polyvalent Immunogen
Identification System                    a density surrounding each corre-
                                         sponding grid point in each one of        Bette T. M. Korber (T-10)
Christen M. Frankle (ISR-1)              the standard templates. The stan-         U.S. Patent 7,172,761
U.S. Patent 7,161,150                    dard templates and the histograms         The present invention relates, gener-
A portable radiation detector using      are applied to grid points on the         ally, to a polyvalent immunogen
a high-purity germanium crystal          experimental electron density map         and, more particularly, to a method
as the sensing device. The crystal       to form new estimates of electron         of inducing neutralizing antibod-
is fabricated such that it exhibits a    density at each grid point in the         ies against HIV and to a polyvalent
length to width ratio greater than       experimental electron density map.        immunogen suitable for use in such
1:1 and is oriented within the detec-                                              a method.
tor to receive radiation along the       Off-axis Cooling of Rotating
width of said crystal. The crystal is    Devices Using a Crank-                    Early Leukemia Diagnostics
located within a container pressur-                                                Using Microsphere Arrays
                                         shaped Heat Pipe
ized with ultra-pure nitrogen, and
the container is located within a        Todd A. Jankowski (AET-1)                 John P. Nolan (B-5)
cryostat under vacuum.                   F. Coyne Prenger (AET-1)                  Feng Zhou
                                         Joseph A. Waynert (ESA-AET)               U.S. Patent 7,179,598
Statistical Density                      U.S. Patent 7,168,480                     The present invention provides
Modification Using Local                 The present invention is a crank-         methods and kits for detecting chro-
                                         shaped heat pipe for cooling rotat-       mosome translocations. The present
Pattern Matching
                                         ing machinery and a corresponding         invention further provides methods
Thomas C. Terwilliger (B-9)              method of manufacture. The crank-         for diagnosing cancer.
U.S. Patent 7,167,808                    shaped heat pipe comprises a sealed
A computer implemented method            cylindrical tube with an enclosed         Methods for Sequencing GC-
modifies an experimental electron        inner wick structure. The crank-          Rich and CCT Repeat DNA
density map. A set of selected           shaped heat pipe includes a con-
                                                                                   Templates
known experimental and model             denser section, an adiabatic section,
electron density maps is provided        and an evaporator section.                Donna L. Robinson (EES-6)
and standard templates of elec-          The crank-shape is defined by a           U.S. Patent 7,179,602
tron density are created from the        first curve and a second curve exist-     The present invention is directed
selected experimental and model          ing in the evaporator section or the      to a PCR-based method of cycle
electron density maps by clustering      adiabatic section of the heat pipe.       sequencing DNA and other polynu-
and averaging values of electron         A working fluid within the heat           cleotide sequences having high CG
density in a spherical region about      pipe provides the heat transfer           content and regions of high GC con-
each point in a grid that defines        mechanism.                                tent, and includes for example DNA
each selected known experimental                                                   strands with a high Cytosine and/
and model electron density maps.                                                   or Guanosine content and repeated
Histograms are also created from                                                   motifs such as CCT repeats.
the selected experimental and
model electron density maps that
relate the value of electron density
at the center of each of the spherical
8                                                                                          2007 Technology Transfer Awards
Outstanding Innovation                                                                       Los Alamos National Laboratory

Fabrication of Multilayered              Waveguide-based Optical                    Quenching Methods for
Thin Films via Spin-assembly             Chemical Sensor                            Background Reduction in
Jeanne M. Robinson (C-PCS)               Karen M. Grace (ISR-4)
                                                                                    Luminescence-based Probe-
Joanna L. Casson (C-PCS)                 Basil I. Swanson (C-DO)                    target Binding Assays
Malkiat S. Johal (C-PCS)                 U.S. Patent 7,190,851                      Hong Cai (B-7)
Hsing-Lin Wang (C-PCS)                   The invention provides an appara-          Peter M. Goodwin (MPA-CINT)
U.S. Patent 7,179,679                    tus and method for highly selective        Richard A. Keller (B-9)
A process of forming multilayer thin     and sensitive chemical sensing. Two        Rhiannon L. Nolan (B-5)
film heterostructures is disclosed       modes of laser light are transmitted       U.S. Patent 7,202,036
and includes applying a solution         through a waveguide, refracted by          Background luminescence is
including a first water-soluble poly-    a thin film host reagent coating on        reduced from a solution containing
mer from the group of polyanionic        the waveguide, and analyzed in a           unbound luminescent probes, each
species, polycationic species and        phase sensitive detector for changes       having a first molecule that attaches
uncharged polymer species onto           in effective refractive index. Sensor      to a target molecule and having an
a substrate to form a first coating      specificity is based on the particu-       attached luminescent moiety and
layer on the substrate, drying the       lar species selective thin films of        luminescent probe/target adducts.
first coating layer on the substrate,    host reagents which are attached           Quenching capture reagent mol-
applying a solution including a          to the surface of the planar optical       ecules are formed that are capable
second water-soluble polymer from        waveguide. The thin film of host           of forming an adduct with the
the group of polyanionic species,        reagents refracts laser light at differ-   unbound luminescent probes
polycationic species and uncharged       ent refractive indices according to        and having an attached quencher
polymer species onto the substrate       what species are forming inclusion         material effective to quench lumi-
having the first coating layer to        complexes with the host reagents.          nescence of the luminescent moi-
form a second coating layer on                                                      ety. The quencher material of the
the first coating layer wherein the      Polyvalent Immunogen                       capture reagent molecules is added
second water-soluble polymer is                                                     to a solution of the luminescent
of a different material than the first   Bette T. M. Korber (T-10)
                                                                                    probe/target adducts and binds
water-soluble polymer, and drying        U.S. Patent 7,195,768
                                                                                    in a proximity to the luminescent
the second coating layer on the first    The present invention relates, gener-      moiety of the unbound lumines-
coating layer so as to form a bilayer    ally, to a polyvalent immunogen            cent probes to quench lumines-
structure on the substrate. Option-      and, more particularly, to a method        cence from the luminescent moiety
ally, one or more additional apply-      of inducing neutralizing antibod-          when the luminescent moiety is
ing and drying sequences can be          ies against HIV and to a polyvalent        exposed to exciting illumination.
repeated with a water-soluble poly-      immunogen suitable for use in such         The quencher capture reagent does
mer from the group of polyanionic        a method.                                  not bind to probe molecules that are
species, polycationic species, and                                                  bound to target molecules and the
uncharged polymer species so that                                                   probe/target adduct emission is not
a predetermined plurality of layers                                                 quenched.
are built up upon the substrate.




2007 Technology Transfer Awards                                                                                          9
Los Alamos National Laboratory                                                                      Outstanding Innovation


Electrodes for Solid State              High Specific Power, Direct                a foil operatively placed in front
Gas Sensor                              Methanol Fuel Cell Stack                   of the first detector, and a second
                                                                                   detector that detects the flux of
Rangachary Mukundan (MPA-11)            John C. Ramsey (P-25)                      heavy and light ions.
Eric L. Brosha (MPA-11)                 Mahlon S. Wilson (MPA-11)
Fernando Garzon (MPA-11)                U.S. Patent 7,214,442
                                                                                   Spray Shadowing for Stress
U.S. Patent 7,214,333                   The present invention is a fuel cell       Relief and Mechanical
A mixed potential electrochemical       stack including at least one direct
                                                                                   Locking in Thick Protective
sensor for the detection of gases       methanol fuel cell. A cathode
has a ceria-based electrolyte with a    manifold is used to convey ambient         Coatings
surface for exposing to the gases to    air to each fuel cell, and an anode        Kendall Hollis (MST-6)
be detected, and with a reference       manifold is used to convey liquid          Brian Bartram (DE-9)
wire electrode and a sensing wire       methanol fuel to each fuel cell. Tie-      U.S. Patent 7,220,458
electrode extending through the         bolt penetrations and tie-bolts are
                                                                                   A method for applying a protective
surface and fixed within the electro-   spaced evenly around the perimeter
                                                                                   coating on an article, comprising
lyte as the electrolyte is compressed   to hold the fuel cell stack together.
                                                                                   the following steps: selecting an
and sintered. The electrochemical       Each fuel cell uses two graphite-
                                                                                   article with a surface for applying
sensor is formed by placing a wire      based plates. One plate includes a
                                                                                   a coating thickness; creating under-
reference electrode and a wire sens-    cathode active area that is defined
                                                                                   cut grooves on the article, where
ing electrode in a die, where each      by serpentine channels connect-
                                                                                   the grooves depend beneath the
electrode has a first compressed        ing the inlet manifold with an
                                                                                   surface to a bottom portion with
planar section and a second section     integral flow restrictor to the outlet
                                                                                   the grooves having an upper width
depending from the first section        manifold. The other plate includes
                                                                                   on the surface and a lower width
with the second section of each         an anode active area defined by
                                                                                   on the bottom portion connected
electrode extending axially within      serpentine channels connecting
                                                                                   by side walls, where at least one of
the die. The die is filled with an      the inlet and outlet of the anode
                                                                                   the side walls connects the upper
oxide-electrolyte powder and the        manifold. Located between the two
                                                                                   width and the lower width to form
powder is pressed within the die        plates is the fuel cell active region.
                                                                                   an undercut angle with the surface
with the wire electrodes. The wire-
                                                                                   less than 90°; and, applying the
electrodes and the pressed oxide-       Apparatus and Method                       protective coating onto the article to
electrolyte powder are sintered to
                                        for Hydrogen and Oxygen                    fill the undercut grooves and cover
form a ceramic electrolyte base with
a reference wire electrode and a        Mass Spectrometry of the                   the surface, thereby forming weak
                                        Terrestrial Magnetosphere                  paths within the protective coating.
sensing wire electrode depending
therefrom.                              Herbert O. Funsten (ISR-DO)
                                        Eric E. Dors (ISR-1)
                                        Ronnie W. Harper (ISR-1)
                                        U.S. Patent 7,217,918
                                        A detector element for mass spec-
                                        trometry of a flux of heavy and light
                                        ions, that includes: a first detector to
                                        detect light ions that transit through


10                                                                                          2007 Technology Transfer Awards
Outstanding Innovation                                                                    Los Alamos National Laboratory

Gold-coated Nanoparticles                Noninvasive                            and insects commonly associated
for Use in Biotechnology                 Characterization of a                  with high wind outdoors and a
Applications                             Flowing Multiphase                     deflector plate in communication
                                                                                with incoming air from the pre-
Douglas E. Berning (N-2)
                                         Fluid Using Ultrasonic                 separator stage that directs the air
Robert H. Kraus, Jr. (LDRD-PO)           Interferometry                         radially and downward uniformly
Robert W. Atcher (B-DO)                  Dipen N. Sinha (MPA-11)                into a plurality of accelerator jets
Jurgen G. Schmidt (B-9)                  U.S. Patent 7,228,740                  located in a manifold of a virtual
U.S. Patent 7,226,636                                                           impactor, the manifold being
                                         An apparatus for noninvasively
A process of preparing gold-coated                                              cylindrical and having a top, a base,
                                         monitoring the flow and/or the
magnetic nanoparticles is disclosed                                             and a wall, with the plurality of
                                         composition of a flowing liquid
and includes forming a suspension                                               accelerator jets being located in the
                                         using ultrasound is described. The
of magnetic nanoparticles within a                                              top of the manifold and receiving
                                         position of the resonance peaks for
suitable liquid, adding an amount                                               the directed air and accelerating
                                         a fluid excited by a swept-frequency
of a reducible gold compound and                                                directed air, thereby creating jets of
                                         ultrasonic signal have been found to
a reducing agent to the suspension,                                             air penetrating into the manifold,
                                         change frequency both in response
and, maintaining the suspension for                                             where a major flow is deflected
                                         to a change in composition and in
time sufficient to form gold-coated                                             to the walls of the manifold and
                                         response to a change in the flow
magnetic nanoparticles.                                                         extracted through ports in the walls.
                                         velocity thereof. Additionally,
                                                                                A plurality of receiver nozzles are
                                         the distance between successive
                                                                                located in the base of the manifold
Nanocrystal/Sol-gel                      resonance peaks does not change
                                                                                coaxial with the accelerator jets,
Nanocomposites                           as a function of flow, but rather in
                                                                                and a plurality of matching flow
                                         response to a change in composi-
Melissa A. Petruska (C-PCS)                                                     restrictor elements are located in
                                         tion. Thus, a measurement of both
Victor L. Klimov (C-PCS)                                                        the plurality of receiver nozzles for
                                         parameters (resonance position and
U.S. Patent 7,226,953                                                           balancing and equalizing the total
                                         resonance spacing), once calibrated,
                                                                                minor flow among all the plurality
The present invention is directed to     permits the simultaneous determi-
                                                                                of receiver nozzles, through which a
solid composites including colloidal     nation of flow rate and composition
                                                                                lower, fractional flow extracts large
nanocrystals within a sol-gel host or    using the apparatus and method of
                                                                                particle constituents of the air for
matrix and to processes of forming       the present invention.
                                                                                collection on a sample filter after
such solid composites. The present
                                                                                passing through the plurality of
invention is further directed to alco-   Environmental Continuous               receiver nozzles and the plurality of
hol soluble colloidal nanocrystals
                                         Air Monitor Inlet with                 matching flow restrictor elements.
useful in formation of sol-gel based
solid composites.
                                         Combined Preseparator and
                                         Virtual Impactor
                                         John C. Rodgers (HSR-4)
                                         U.S. Patent 7,232,477
                                         An inlet for an environmental air
                                         monitor is described wherein a pre-
                                         separator interfaces with ambient
                                         environment air and removes debris

2007 Technology Transfer Awards                                                                                     11
Los Alamos National Laboratory                                                                    Outstanding Innovation


Bioassay and Biomolecular              get binder being too large to pass         lated carrier back to the surface. A
Identification, Sorting, and           through the size exclusion filter,         RF transceiver is located at the sur-
Collection Methods using               and then sending a solution of one         face and is connected between the
                                       or more potential pharmaceutical           electrically conductive pipe and the
Magnetic Microspheres                  chemicals (preferably an aqueous           electrical conductor for transmitting
Robert H. Kraus, Jr. (LDRD-PO)         solution) through the same conduit         a RF signal that is confined between
Feng Zhou                              to the size exclusion filter after         the electrically conductive well pipe
John P. Nolan (B-5)                    target binder has collected on the         and the electrical conductor to the
U.S. Patent 7,232,691                  filter. The potential pharmaceuti-         modulated reflectance apparatus,
                                       cal chemicals are small enough to          and for receiving reflected data on
The present invention is directed to
                                       pass through the filter. Afterwards,       the well from the modulated reflec-
processes of separating, analyzing
                                       x-rays are sent from an x-ray source       tance apparatus.
and/or collecting selected species
                                       to the size exclusion filter, and if the
within a target sample by use of
                                       potential pharmaceutical chemicals         High Rate Buffer Layer
magnetic microspheres including
                                       form a complex with the target
magnetic particles, the magnetic                                                  for IBAD MgO Coated
                                       binder, the complex produces an
microspheres adapted for attach-                                                  Conductors
                                       x-ray fluorescence signal having an
ment to a receptor agent that can
                                       intensity that indicates that a com-       Stephen R. Foltyn (MPA-STC)
subsequently bind to selected
                                       plex has formed.                           Quanxi Jia (MPA-STC)
species within the target sample.
The magnetic microspheres can                                                     Paul N. Arendt (MPA-STC)
be sorted into a number of distinct    RF Transmission Line and                   U.S. Patent 7,258,927
populations, each population with a    Drill/Pipe String Switching                Articles are provided including a
specific range of magnetic moments     Technology for Down-hole                   base substrate having a layer of an
and different receptor agents can be   Telemetry                                  oriented material Thereon, and, a
attached to each distinct population                                              layer of hafnium oxide upon the
of magnetic microsphere.               David D. Clark (P-23)                      layer of an oriented material. The
                                       Don M. Coates                              layer of hafnium oxide can further
Method and Apparatus for               U.S. Patent 7,256,707                      include a secondary oxide such
Detecting Chemical Binding             A modulated reflectance well telem-        as cerium oxide, yttrium oxide,
                                       etry apparatus having an electrically      lanthanum oxide, scandium oxide,
Benjamin P. Warner (MPA-MC)            conductive pipe extending from             calcium oxide and magnesium
George J. Havrilla (C-CSE)             above a surface to a point below the       oxide. Such articles can further
Thomasin C. Miller (C-ACS)             surface inside a casing. An electrical     include thin films of high tempera-
Cyndi A. Wells (IAT-1)                 conductor is located at a position a       ture superconductive oxides such
U.S. Patent 7,241,381                  distance from the electrically con-        as YBCO upon the layer of hafnium
The method for screening bind-         ductive pipe and extending from            oxide or layer of hafnium oxide and
ing between a target binder and        above the surface to a point below         secondary oxide.
potential pharmaceutical chemicals     the surface. Modulated reflectance
involves sending a solution (prefer-   apparatus is located below the sur-
ably an aqueous solution) of the       face for modulating well data into
target binder through a conduit        a RF carrier transmitted from the
to a size exclusion filter, the tar-   surface and reflecting the modu-


12                                                                                        2007 Technology Transfer Awards
Outstanding Innovation                                                                    Los Alamos National Laboratory

Multifunctional Nanocrystals            the methylene blue in response           Directed Evolution Methods
                                        to the oxygen concentration to           for Improving Polypeptide
Victor I. Klimov (C-PCS)                which the sensor is exposed. The
Jennifer A. Hollingsworth (C-PCS)                                                Folding and Solubility and
                                        sensor was found to have a linear
Scott A. Crooker (MPA-NHMFL)            response to oxygen concentration
                                                                                 Superfolder Fluorescent
Hyungrak Kim (C-PCS)                    on a semi-logarithmic scale within       Proteins Generated Thereby
U.S. Patent 7,261,940                   the oxygen concentration range           Geoffrey S. Waldo (B-9)
Multifunctional nanocomposites are      between 0.6% and 20.9%, a response       U.S. Patent 7,271,241
provided including a core of either     time and a recovery time of about 3
a magnetic material or an inor-                                                  The current invention provides
                                        s, and to exhibit good reversibility
ganic semiconductor, and, a shell                                                methods of improving folding of
                                        and repeatability. An increase in
of either a magnetic material or an                                              polypeptides using a poorly folding
                                        temperature from 21°C to 35°C does
inorganic semiconductor, wherein                                                 domain as a component of a fusion
                                        not affect the net absorption of the
the core and the shell are of differ-                                            protein comprising the poorly
                                        sensor.
ing materials, such multifunctional                                              folding domain and a polypeptide
nanocomposites having multifunc-                                                 of interest to be improved. The
                                        Thin Film Mixed                          invention also provides novel green
tional properties including mag-
                                        Potential Sensors                        fluorescent proteins (GFPs) and
netic properties from the magnetic
material and optical properties from                                             red fluorescent proteins that have
                                        Fernando H. Garzon (MPA-11)
the inorganic semiconductor mate-                                                enhanced folding properties.
                                        Eric L. Brosha (MPA-11)
rial. Various applications of such      Rangachary Mukundan (MPA-11)
multifunctional nanocomposites are      U.S. Patent 7,264,700
also provided.                          A mixed potential sensor for
                                        oxidizable or reducible gases and
Oxygen Detection Using                  a method of making. A substrate
Evanescent Fields                       is provided and two electrodes
                                        are formed on a first surface of
Yixiang Duan (C-CSE)                    the substrate, each electrode being
Weenqing Cao (MPA-STC)                  formed of a different catalytic mate-
U.S. Patent 7,263,246                   rial selected to produce a differen-
An apparatus and method for the         tial voltage between the electrodes
detection of oxygen using optical       from electrochemical reactions of
fiber based evanescent light absorp-    the gases catalyzed by the electrode
tion. Methylene blue was immobi-        materials. An electrolytic layer of an
lized using a sol-gel process on a      electrolyte is formed over the elec-
portion of the exterior surface of an   trodes to cover a first portion of the
optical fiber for which the cladding    electrodes from direct exposure to
has been removed, thereby form-         the gases with a second portion of
ing an optical oxygen sensor. When      the electrodes uncovered for direct
light is directed through the optical   exposure to the gases.
fiber, transmitted light intensity
varies as a result of changes in the
absorption of evanescent light by

2007 Technology Transfer Awards                                                                                     13
Los Alamos National Laboratory                                                             Outstanding Innovation


Copyrights Asserted in           Blackbox, Version 1.0                     ate for each individual’s age and
                                                                           employment status). The time-step
Fiscal Year 2007                 Johan Bollen (STBPO-RL)                   resolution of the model is 12 hours,
                                 Herbert Van De Sompel (STBPO-RL)          so each individual has a set of day-
                                 Digital library usage logs are a          time and nighttime contact groups,
                                 highly valuable source of informa-        which may be geographically
                                 tion that can be exploited for science-   separated (particularly for working
                                 support services on the level of local    adults who commute). In addition,
                                 institutions and the global scientific    people may take occasional random
                                 community. The Blackbox project           long-distance trips with speci-
                                 has developed as standards-based          fied frequency, destination choice,
                                 architecture for the recording,           and trip duration algorithms. The
                                 storage, and distribution of digi-        output typically consists of daily or
                                 tal library usage logs. Local usage       half-daily files with the current and
                                 events are recorded by OpenURL,           cumulative number of symptom-
                                 enable linking servers (such as the       atic individuals in each geographic
                                 SFX Link Resolver), and are stored        location, typically a U.S. Census
                                 as ContexObjects, which are then          tract, and various population-wide
                                 serialized as XML objects. The latter     data on the numbers of incubat-
                                 can then be locally exposed and           ing and asymptomatic individuals,
                                 centrally harvested by means of the       the number of affected locations,
                                 Open Archives Initiative Protocol         usage of vaccines or antiviral drugs,
                                 for Metadata Harvesting. A set of         and so forth. The model runs on
                                 analysis mechanisms and services          either serial or parallel computers,
                                 have been developed to make use           enabling simulations of populations
                                 of both local and aggregated logs,        with arbitrary numbers of individu-
                                 such as a software to rank items          als (280 million people are routinely
                                 according to their scientific impact      used in U.S. studies, utilizing
                                 and a system to generate document         100–500 processors).
                                 recommendations.
                                                                           The EpiCast software may be
                                                                           utilized in planning for potential
                                 EpiCast, Version 1.0
                                                                           pandemic outbreaks of influenza
                                 Timothy Clark Germann (T-12)              or other infectious diseases. This
                                 The EpiCast software models infec-        includes but is not limited to: risk
                                 tious disease spread throughout a         assessment (potential medical man-
                                 spatially distributed population of       power, and infrastructure costs),
                                 individuals, each of whom belongs         resource prioritization, develop-
                                 to a variety of contact (mixing)          ment and assessment of mitiga-
                                 groups in which person-to-person          tion strategies, and as a real-time
                                 transmission may occur (e.g., house-      tabletop exercise simulation model.
                                 hold, school, workplace, daycare,         More broadly, the underlying
                                 neighborhood, etc., as appropri-          agent-based model may be adapted


14                                                                                 2007 Technology Transfer Awards
Outstanding Innovation                                                                       Los Alamos National Laboratory

to other applications such as “social-   tion hardware. The code is modular        lel applications. gfortran2xml is
epidemics,” including the spread of      and uses a hardware abstraction           used in projects that generate code
fashion trends.                          layer to allow either the acquisition     for Fortran and C/C++ language
                                         hardware or the communication             interoperability.
LED Tree                                 protocol to easily be changed.

Terrence F. Bott (D-5)
                                                                                   ROMPIO, Version 1.0.0
                                         MPI-FTW, Version 1.0
Stephen Ward Eisenhawer (D-5)                                                      Stephen W. Hodson (HPC-5)
This computer program allows the         Gary Grider (HPC-DO)
                                                                                   ROMPIO, Version 1.0.0 is software
user to construct logic gate trees       Alfred Torrez (HPC-1)
                                                                                   designed to measure MPI collec-
using a graphical interface. A hyper-    MPI-File Tree Walk (MPI-FTW)              tive, independent, asynchronous,
link capability is provided.             navigates a directory tree by dynami-     and POSIX file I/O performance,
                                         cally allocating processes when new       synthesizing how applications
Tailorable Rapid Acquisition             directories are found. When a process     utilize file systems in the LANL
and Visualization Software               completes a walk through a directory      ASC computing environment. File
                                         (no more subdirectories), the process     layouts include N processors to N
(TRAViS), Version 1.0
                                         is flagged as not busy. That process      files and N processors to 1 file. Write
(formerly known as ORCA PC)              is then free to walk a new directory      access patterns include non-strided
Mark Naivar (B-9)                        encountered by another process.           and strided. Network performance
                                         Commands can be executed at each          measurements can also be obtained
The TRAViS software runs on a
                                         new directory found. Upon comple-         for relevant MPI collective calls.
desktop computer, and the C++
                                         tion, file and directory counts as well
code has been designed to run on
                                         as time to complete are reported.         Miniature Cytometric
Windows, Mac, or Linux computers.
The software communicates with the                                                 Acquisition System (MiCAS
acquisition hardware to set up and
                                         gfortran2xml, Version 0.6                 DSP), Version 1.0
acquire data from a flow cytometer.      Craig E Rasmussen (CCS-1)
                                                                                   Mark Naivar (B-9)
The software has basic acquisition       Christopher Douglas Rickett (CCS-1)
and analysis capabilities including:     Matthew Joseph Sottile (CCS-2)            We have created a capable yet inex-
real-time data displays with stats,                                                pensive and low power single-chip
                                         The software tool, gfortran2xml,
real-time gating, a virtual scope to                                               acquisition system for flow cytomet-
                                         creates an XML representation of a
display the raw captured waveforms                                                 ric applications. Using a commercial
                                         parse tree created by the GNU For-
from any detector, persistent and                                                  DSP chip from Texas Instrumentals
                                         tran Compiler. The XML output file
named instrument settings with the                                                 (TMS320F2808), we acquire continu-
                                         describes Fortran interfaces (proce-
ability to save data in FCS 3.0 For-                                               ous data from up to four analog
                                         dure names and associated parame-
mat. The list mode data files are com-                                             detectors using the integrated
                                         ters and return values). gfortran2xml
patible with a number of commercial                                                ADC, as well as up to two digital
                                         is useful for projects that perform
analysis packages. The code cur-                                                   photon-counting detectors. The DSP
                                         static analysis to modify existing
rently compiles without modification                                               firmware detects the events (pulses)
                                         Fortran source files. For example,
for all three supported platforms,                                                 in the raw data streams, processes
                                         from information in the XML output
but the Windows version does not                                                   the raw waveforms of interest into
                                         files, tools can automatically insert
implement the FireWire interface and                                               correlated peak and area measure-
                                         performance monitoring calls to aid
therefore cannot talk to the acquisi-                                              ments, and sends the list mode
                                         in improving the speed of paral-

2007 Technology Transfer Awards                                                                                        15
Los Alamos National Laboratory                                                                    Outstanding Innovation

data over an RS-232 port to a host      Rational Vaccine Design                  SAMRSolvers, Version 0.1
computer for display, analysis, and     Code, Version 1.0
storage. The firmware has been                                                   Michael Pernice (CCS-3)
optimized so the ADC can be run         Tanmoy Bhattacharya (T-08)               Bobby Philip (T-07)
at full speed, which allows pulse       William Mclean Fischer (T-10)            SAMRSolvers is a collection of mul-
widths as small as 2.5uSec to be        Simon John Perkins (IRS-2)               tilevel solvers for systems of linear
measured from a single detector, or     James Theiler (ISR-2)                    equations that result from finite
10 µsec pulse widths when acquir-       The Rational Vaccine Design Code is      volume discretization of an elliptic
ing from 4 detectors simultaneously.    a set of software utilities written in   partial differential equation on a
The system can be easily scaled by      C++ and Perl that assist with the task   block-structured (or patch-based)
adding more chips and/or chang-         of finding one or more sequences of      locally refined grid. SAMRSolv-
ing the number of detectors each        amino acids that maximally match         ers provides implementations of
chip handles.                           amino acid sequences and can then,       the Fast Adaptive Composite grid
                                        potentially, be used as the basis for    (FAC) method, Asynchronous Fast
Open Reconfigurable                     synthetic vaccines that provide better   Adaptive Composite grid (AFAC)
Cytometric Acquisition                  cross protection against HIV than        method, and the AFACx method,
                                        vaccines made from natural virus         which is a less expensive version
System (ORCAS DSP),                                                              of AFAC that smooths the error
                                        strains.
Version 1.0                                                                      instead of solving for it on all but
Mark Naivar (B-9)                       EEG Boundary Elements                    the coarsest level. These methods
                                                                                 can be shown to converge at rates
The ORCA DSP firmware runs              Toolbox, Version 0.1
                                                                                 that are independent of the number
on a commercial embedded DSP
                                        Sergey M. Plis (P-21)                    of refinement levels. SAMRSolvers
board. It is written in C++ and uses
                                        The toolbox provides an opportunity      is intended for use with SAMRAI
no operating system or task sched-
                                        to perform forward calculations for      v2.0 and requires the SAMRUtili-
uling software. The firmware is
                                        EEG. Several available approaches        ties package, also available from the
responsible for collecting raw data
                                        described in the literature are          same authors.
from one or more custom electronic
boards, processing the data into list   implemented. Dual layer approach
                                        is represented in four modifications     SAMRUtilities, Version 0.1
mode parameters, and sending the
processed results to a host computer    that vary in the implementation and      Michael Pernice (CCS-3)
over the IEEE 1394 (FireWire) inter-    running time complexity and the          Bobby Philip (T-07)
face. Parts of the code are highly      accuracy of the results. A symmetric
                                                                                 SAMRUtilities is a collection of utili-
optimized because the performance       BEM approach is also implemented.
                                                                                 ties that we have found to be useful
directly impacts the maximum            The toolbox can be used to calculate
                                                                                 for certain operations required on
throughput of the system. The code      stiffness matrices that can later be
                                                                                 block-structured (or patch-based)
also implements the communica-          used to calculate the final potential
                                                                                 locally refined grids. SAMRUtil-
tion protocol for the host to send      distribution.
                                                                                 ties provides a high-level means
commands and get status from the                                                 to represent the structure of the
DSP board.                                                                       boundaries of refinement levels—
                                                                                 so-called coarse/fine interfaces,
                                                                                 since these are the locations where
                                                                                 local resolution changes. At these

16                                                                                        2007 Technology Transfer Awards
Outstanding Innovation                                                                    Los Alamos National Laboratory

interfaces, coarse grid information     Truchas, Version 2.2                    slower cooling of the solidified part
often must be interpolated to finer                                             down to room temperature.
resolution, and SAMRUtilities also      Juan Carlos Ramirez (MST-8)
                                        Marius Stan (CCS-2)                     Truchas has realistic physical mod-
provides methods to interpolate                                                 els for electromagnetic radiation,
independently in directions tangen-     Yunghee Kang (CCS-2)
                                        Michael Lynn Hall (CCS-2)               alloy solidification and resulting
tial and normal to the coarse/fine                                              micro/macro segregation phenom-
interface. Implementations of several   Edward Dwight Dendy (X-3)
                                        Sharen Jane Cummins (CCS-2)             ena, free surface incompressible
higher-order interpolation schemes                                              flow heat, heat transfer, complex
for transferring information interior   Lawrence James Cox (CCS-DO)
                                        Mark A. Christon (CCS-2)                three-dimensional geometric effects
to a patch are also provided.                                                   microstructural nucleation and
                                        Neil N. Carlson (CCS-2)
                                        Markus Berndt (T-07)                    evolution, surface tension, solid/
Muon Tomography                                                                 solid phase transition effects,
                                        Travis Mitchell Austin (T-07)
Reconstruction and Analysis             Robert M. Aikin (MST-6)                 and residual stress buildup and
Code (MURAD)                            Matthew Wayne Williams (X-1-TA)         response. Truchas can be viewed as
                                        John Alexander Turner (CCS-2)           a tool useful for foundry people in
Michael J. Sossong (X-1-TA)                                                     understanding, Truchas can also aid
                                        Truchas is software for simulating      in the design of improved casting
The software is an implementation
                                        casting processes currently in use      processes which lead to cast metal
of an analysis framework to aid in
                                        in LANL and industrial foundries.       alloy parts which meet microstruc-
the analysis of muon scattering data.
                                        Truchas could be used to simu-          tural, geometrical, and property
Within this analysis framework, an
                                        late castings on scales from dental     specifications. This software can
EM algorithm to find maximum like-
                                        fillings to engine blocks to large      also be useful in simulating any
lihood scattering density solution to
                                        mining equipment because of the         physical process where incompress-
a muon-scattering dataset is imple-
                                        breadth and generality of the physi-    ible fluid flow, convective/conduc-
mented. Other functionality includes
                                        cal models Truchas embodies to          tive heat transfer, solid/solid phase
muon trajectory reconstruction, voxel
                                        simulate these processes. However,      chase, and thermoelastic material
reconstruction visualization and file
                                        it is also a very general engineering   response take place.
I/O.
                                        analysis tool for a wide variety of
                                        industrial and natural phenomena.
Muon Tomography Vehicle                                                         SIF C I/O Library
                                        Truchas is written in Fortran 90,
Scanner Simulation Suite                primarily for high-performance          Damian R. Eads (ISR-2)
Michael J. Sossong (X-1-TA)             parallel computing platforms, but       The Sparse Image Format (SIF)
                                        the software is portable to any plat-   is a file format for storing sparse
This is an implementation of the        form possessing a modern Fortran
GEANT4 toolkit to simulate the                                                  raster images. It works by breaking
                                        90 compiler (including PCs). The        an image down into tiles. Space is
performance of a vehicle scanner to     Truchas software targets simulating
search for SNM in passenger vehi-                                               saved by only storing tiles that are
                                        the entire casting process, beginning   non-uniform, (i.e., tiles with two
cles. The software performs physics     with the preheat of mold materials
simulations to be used in evaluating                                            different pixel values). If a tile is
                                        by electromagnetic induction, free      completely uniform, its common
the performance of a vehicle scanner.   surface flow of a molten alloy being
The software contains original work                                             pixel value is stored instead of the
                                        poured into a mold, followed by the     complete tile raster. A C library is
including detector design, a muon-      rapid initial cooling and solidifica-
source generator, and vehicle and                                               provided to manipulate files in SIF
                                        tion of that alloy, ending with the     format.
scene designs.

2007 Technology Transfer Awards                                                                                     17
Los Alamos National Laboratory                                                                Outstanding Innovation


Cohesive Zone Model User                Gazebo, Version 1.0                   nally developed for analyzing mul-
Element (CZM UEL),                                                            tispectral satellite data and has been
                                        Craig Warne Idler (HPC-5)             applied to panchromatic (grayscale)
Version 1.0
                                        Richard Alan Light (HPC-5)            and hyperspectral satellite data,
Trevor Bair Tippetts (WT-2)             Gazebo is a suite of software com-    aerial imagery, and various kinds
Cohesive Zone Model User Element        ponents used to test, monitor, and    of ground-based camera (including
(CZM UEL) is an implementation          analyze the health of a supercom-     frames from video imagery) and
of a Cohesive Zone Model as an          puter. The goal is to minimize the    biomedical imagery. Applications
element for use in finite element       time it takes to find problems.       for Genie Pro include:
fracture simulations.                                                         • Terrain-type mapping, including
                                        Gazebo is designed to be modular
                                                                                 agricultural crops and natural
                                        with many individual parts contrib-
Tracked Vehicle, Revision 75                                                     vegetation;
                                        uting to the whole. Current compo-
                                                                              • Road, rail, and river network
Eric Y. Raby (ISR-3)                    nents include:
                                                                                 mapping;
                                        • Web-based test execution and test
Revision 75 of the tracked vehicle                                            • Broad area search for vehicles and
                                          run output analysis package
software, based on tank 57 is a soft                                             buildings;
                                        • Cluster-resident test execution
real-time simulation of differen-                                             • Cancer identification in histologi-
                                          package
tially steered, tracked mobile robot,                                            cal images.
                                        • Server/client communication
which, because of the track flip-         package
pers, resembles the iRobot PackBot.     • Acceptance testing package
                                                                              PFLOTRAN, Version 1.0
Open source libraries are used for      • Hooks in place for future expan-    Glenn Edward Hammond (EES-6)
the physics engine, the display and       sion—viewing and analysis of        Peter C. Lichtner (EES-6)
user interface, and the program           hardware monitoring data; and       Chuan Lu (EES-6)
command line and configuration            statistical analysis of test run    Richard T. Mills (EES-6)
file parameters. The simulation           results and execution times.
can be controlled by a USB joystick                                           Pflotran is a massively parallel, mul-
or the keyboard. The configura-                                               tiphase, multicomponent, reactive
                                        Genie Pro, Version 2.0                flow and transport code. Paralleliza-
tion file contains demonstration
model parameters of no particular       Steven Brumby (ISR-2)                 tion is based on domain decomposi-
vehicle. The simulation can be used     Damian R. Eads (ISR-2)                tion achieved through the use of the
as a starting point for those doing     Kimberley Edlund (ISR-2)              PETSc parallel libraries (Portable
tracked vehicle simulations.            Diana M. Esch-mosher (ISR-3)          Extensible Toolkit for Scientific
                                        Mark Galassi (ISR-1)                  Computing developed at Argonne
SampleCollector, Version 1.0            Neal Harvey (ISR-2)                   National Laboratory [ANL]).
                                        Simon John Perkins (ISR-2)            Pflotran is being used to model
Craig Blackhart (AET-5)                 Reid B. Porter (ISR-2)                CO2 sequestration, plutonium
                                        James Theiler (ISR-2)                 migration at the Nevada Test Site,
This software provides a Graphical
                                                                              uranium migration at the Hanford
User Interface (GUI) to enable the      Genie Pro is a general purpose
                                                                              DOE facility, an many other applica-
user of Multi-Purpose Sampling          interactive adaptive tool for auto-
                                                                              tions to groundwater contaminant
Device to interface and record infor-   matically labeling regions and
                                                                              migration under partially saturated,
mation. The software manages col-       finding objects in large amounts of
                                                                              nonisothermal conditions.
lection of data from the multitude of   image data. Genie Pro was origi-
hardware components in the gun.

18                                                                                    2007 Technology Transfer Awards
Outstanding Innovation                                                                      Los Alamos National Laboratory

SEL, Version 1.0                         Patch for CNS                            input/output routines, ability to
                                                                                  more intelligently extrapolate input
Alan Herbert Glasser (T-15)              Paul Alfred Langan (B-8)                 data and some improvements to
SEL is an advanced 2-dimensional         Marat Mustyakimov (B-8)                  certain numerical methods that aid in
fluid simulation code with the fol-      CNS or Crystallography and NMR           accurately solving large systems.
lowing principal features: spatial       System (http://cns.csb.yale.edu/
discretization, harmonic grid gen-       v1.1/) is software that was devel-       IDL Routines
eration, time discretization, static     oped for protein crystal structure
condensation, flux-source form. It is    determination. CNS has a hierarchi-      Cindy R. Christensen (NSTEC)
extensively tested and verified and it   cal structure: a high-level hypertext    Interactive Data Language (IDL)
is efficiently operated on massively     markup language (HTML) user              procedures used for interpretation of
parallel distributed computers.          interface, task-oriented user input      highly time resolved signals. IDL is
                                         files, module files, a symbolic struc-   used to deconvolute detector signals
MESA2D, Version 8.0                      ture determination language (CNS         to remove the instrumental response.
                                         language), and low-level Fortran
Sean Patrick Clancy (X-3)                source code. The CNS language is         N-sim, Version 0.9
Wayne N. Weseloh (X-4)                   sufficiently powerful and flexible
MESA2D is a two-dimensional              that new algorithms can be imple-        Sean M. Brennan (ISR-3)
(Cartesian and Cylindrical) Eulerian     mented and tested without changes        N-sim is an emulation/simulation
hydrodynamics code with high             to the low-level source code. CNS        engine for studying and developing
explosives and material strength         was designed so it could be easily       wireless sensor networks. Wireless
models. Among special features of        adapted by the general scientific        sensor networks are typically com-
MESA2D are its high-order advec-         community.                               posed of small detecting, comput-
tion algorithm, its material interface                                            ing, and communicating platforms
tracking scheme and van Leer mono-       General Spectral Modeling                cooperatively monitoring a given
tonic advection-limiting.                (GSM), Version 1.1                       environment in situ. N-sim allows
                                                                                  software developers to program and
LANL/Sandia DNS Code                     Justin R Oelgoetz (X-1-NAD)              test these programs’ platforms more
                                         GSM is a general atomic kinetics         easily, and researchers to virtualize
Mark Alan Taylor (SNL-ASCI)                                                       experiments before going out into
                                         code for the calculation of emis-
Beth Ann Wingate (CCS-2)                                                          the field. Utilizing new virtualization
                                         sion spectra, developed as part of a
This code solves the 3D and 2D           Ph.D. thesis at Ohio State University    technologies, N-sim emulates the
incompressible Navier-Stokes equa-       and extended here at LANL. Details       computational portion of a sensor
tions and the Boussinesq equations       of the theory, approximations, and       platform, simulates the wireless com-
in a periodic domain. The code is        methodologies it uses can be found       munication portion, and allows for
used for Direct Numerical Simula-        in LA-UR-06-4569 (part of Justin         plug-in modules to simulate source
tion (DNS) of idealized flow such        Oelgoetz's Ph.D. Dissertation). Its      propagation and the detection capa-
as decaying homogeneous isotropic        capabilities include the solving of      bilities of an in-situ sensor platform.
turbulence.                              the atomic kinetics rate equations,      With enough standard scientific com-
                                         calculating emission spectra, and        puting resources, N-sim can emulate
                                         performing basic analysis on these       networks at large scales, which are
                                         calculations. Extensions in version      problematic in the field.
                                         1.1 include faster methods, new

2007 Technology Transfer Awards                                                                                       19
Los Alamos National Laboratory                  Outstanding Innovation


Thermonucleotide BLAST
Jason David Gans (B-7)
ThermonucleotideBLAST is a soft-
ware program for searching a target
database of nucleic acid sequences
using an assay specific query.

Ciao Peer-to-Peer Blackboard
Module
Sean M. Brennan (ISR-3)
Ciao Peer-to-Peer Blackboard Mod-
ule is a fault-tolerant blackboard
communication module for clus-
tered computers. Facilitates dis-
tributed blackboard computations
where each process has its own
copy of the data posting space. It is
for use with the Ciao Prolog system.




20                                      2007 Technology Transfer Awards
Outstanding Innovation                                                                     Los Alamos National Laboratory


Fiscal Year 2007                  Alvarez, Marc (B-8)                           Phase and Radial Motion in Ion Linear
                                   Synthesis of [2H1, 13C], [2H2, 13C] and        Accelerators (PARMELA)
License Income                       [2H3, 13C] Methylarl Sulfones and         Bollen, Johan (STBPO-RL)
Recipients                           Sulfoxides                                 Blackbox, Version 1.0
                                   Synthesis of [2H1, 13C], [2H2, 13C] and      Usage Based Indicators to Assess the
                                     [2H3, 13C]Methylaryl Sulfides                 Impact of Scholarly
                                   Synthesis of Labelled Oxalic Acid Deriv-
                                     atives                                    Bott, Terrence (D-5)
                                   Synthesis of Isotopically Labeled D or L     LED Tree
                                     [13C,2H] Glycerols                        Bourret, Steven (N-1)
                                   Synthesis of 2H- and 13C-Substituted         MiniGrand Family of Software
                                     Dithanes                                   Cosmic-Ray Neutron Background Reduc-
                                  Arendt, Paul (MPA-STC)                          tion Using Localized Coincidence Veto
                                   Improved Buffer Layer Compound for             Neutron Counting
                                     Coated Conductors                         Bowles, Jeffrey (N)
                                   Substrates Structure for Growth of           MiniGrand Family of Software
                                     Highly Oriented and/or Epitaxial
                                     Layers Thereon                            Bradbury, andrew (B-9)
                                   Architecture for Coated Conductors           An Antibody Recognizing Sulfation as a
                                   High-Rate Buffer Layer for IBAD MgO            Post-translational Modification
                                     Coated Conductors                         Bradley, Johnathan (CCS)
                                   Coated Conductors                            Storage and Retrieval of Large Digital
                                   Use of High Current Density Electropol-         Images
                                     ishing for the Preparation of Very
                                     Smooth Substrate Tapes for Coated         Briles, Scott (N)
                                     Conductor Applications                     Identification Coding Schemes for Modu-
                                                                                   lated Reflectance
                                  Asay, Blaine (DE-6)                           Long-Range, Full Duplex, Modulated-
                                   Lead-Free Electric Match Compositions           Reflector Cell Phone for Voice/Data
                                  Audia, Jeffrey (N-1)                             Transmission
                                   1K ADC Unattended Monitoring firm-          Brockway, Dennis (D)
                                     ware (actual name of firmware program      Graphical Input Aggregate Control
                                     is MINIADC)                                  (GIAC)
                                  Backhaus, Scott (MPA-10)                     Bronisz, Lawrence (IAT-2)
                                   Traveling-Wave Device with Mass Flux         Use of High Current Density Electropol-
                                      Suppression                                 ishing for the Preparation of Very
                                   Cascaded Thermoacoustic Devices                Smooth Substrate Tapes for Coated
                                   Circulating Heat Exchangers for Oscil-         Conductor Applications
                                      lating-Wave Engines and Refrigera-
                                      tors                                     Brown, Donald (EES-11)
                                                                                Geothermal Energy Production with
                                  Bai, Ying (N)                                   Supercritical Fluids
                                   MiniGrand Family of Software
                                                                               Brunson, Glen (N-2)
                                  Barbe, Michael (MST-6)                        MiniGrand Family of Software
                                   Laser Production of Articles from Powders
                                                                               Burrell, Anthony (MPA-MC)
                                  Billen, James (LANSCE)                        Fluorescent Beryllium Detection
                                   Phase and Radial Motion in Electron          Reversible Electro-Optic Device Employ-
                                     Linear Accelerators (PARMELA),                ing Aprotic Molten Salts and Method
                                     Version 3.0
2007 Technology Transfer Awards                                                                                          21
Los Alamos National Laboratory                                                                               Outstanding Innovation

 Electrolytes for Electrooptic Devices        Cole, Dean (B)                               Eisenhawer, S.W. (D-5)
    Comprising Ionic Liquids                   Method of Using 5, 10, 15, 20-Tetrakis(4-    LED Tree
 Polymer-Assisted Deposition of Films            Carboxyphenyl) Porphine
 Extension to MXRF IP Portfolio
                                                                                           Estep, Robert (N-2)
 Reversible Electro-Optic Device Employ-
                                              Collins, Michael (N-4)                        MiniGrand Family of Software
                                               Hybrid K-Edge/X-Ray Fluorescence
    ing Aprotic Molten Salts and Method                                                    Ferreri, Vincent (P-24)
                                                 Densitometer (HKED), Version 3.X
 Electrochromic, Salts, Solutions and                                                       Field Enhanced Electrodes for Additive
    Devices                                   Coulter, J. Yates (MPA-STC)                      Injection Non-thermal Plasma (NTP)
                                               Apparatus for Measurement of Critical           Processor
Busick, Deanna (MPA-11)
                                                 Current in Superconductive Tapes
 Composite Bipolar Plate for Electro-                                                      Fisk, Michael (ACS-PO)
   chemical Cells                             Cremers, David (MPA)                          Network Topology Mapper
                                               Laser Production of Articles from Powders
Busse, James (C-ADI)                                                                       Foltyn, Stephen (MPA-STC)
 Lead-Free Electric Match Compositions        Davey, John (MPA-11)                          Improved Buffer Layer Compound for
                                               Catalyst Inks and Method of Application         Coated Conductors
Cabantous, Stephanie (B-9)
                                                 for Direct Methanol Fuel Cells             Substrates Structure for Growth of
 Self-Assembling Split-Fluorescent Pro-
                                                                                               Highly oriented and/or Epitaxial Lay-
    tein Systems                              Dearing, James (D)
                                                                                               ers Thereon
 Circular Permutant GFP Insertion Fold-        Graphical Input Aggregate Control
                                                                                            Enhanced Pinning in Mixed Rare
    ing Reporters                                (GIAC)
                                                                                               Earth-123 Films
 Protein Subcellular Localization Assays
    Using Split Protein-Protein Interac-
                                              Depaula, Raymond (MPA-STC)                    Structure for Improved High Critical
                                               Arrays of Long Carbon Nanotubes for             Current Densities in YBCO
    tion Detection System
                                                 Fiber Spinning                             Architecture for Coated Conductors
Cai, Hong (B-7)                                Apparatus for Measurement of Critical        High-Rate Buffer Layer for IBAD MgO
 DNA Base Mismatch Detection Using               Current in Superconductive Tapes              Coated Conductors
   Flow Cytometry                                                                           Coated Conductors
 DNA Polymorphism Identity Determina-
                                              Dixon, Raymond (MST-6)
                                                                                            Architecture for High Critical Current
                                               Controlled Laser Production of Elongated
   tion Using Flow Cytometry                                                                   Superconducting Tapes
                                                 Articles from Particulates
Cannon, T. Michael (CCS-3)                                                                  High Critical Current Superconducting
 Quality Assessment, Restoration and
                                              Dreiskott, Sascha (MPA)                          Tapes
                                               Use of High Current Density Electropol-      Use of High Current Density Electropol-
   oCr. (QUARC)
                                                 ishing for the Preparation of Very            ishing for the Preparation of Very
Carey, James (EES-6)                             Smooth Substrate Tapes for Coated             Smooth Substrate Tapes for Coated
 Detection of Alkali-Silica Reaction Swell-      Conductor Applications                        Conductor Applications
   ing in Concrete by Staining
 Detection of Concrete Deterioration by
                                              Driscoll, Judith (MPA-STC)                   Freund, Samuel (LANSCE-LC)
                                               Enhanced Pinning in Mixed Rare               Long-Range, Full Duplex, Modulated-
   Staining
                                                 Earth-123 Films                              Reflector Cell Phone for Voice/Data
Chen, Liaohai (B)                                                                             Transmission
 Method for Detecting Biological Agents
                                              Dziewinski, Jacek (WCM-4)
                                               Nitrate Reduction                           Gardner, David (MPA-11)
Clark, David (P-23)                            Electrochemical Reduction of Nitrate in      Pulse Tube Refrigerator with Variable
 Identification Coding Schemes for Modu-          the Presence of an Amide                     Phase Shift
    lated Reflectance                                                                       Traveling-Wave Device with Mass Flux
                                              Ehler, Deborah (C-SIC)
Coates, Don (PA/ P-DO)                                                                         Suppression
                                               Fluorescent Beryllium Detection
 Identification Coding Schemes for Modu-                                                    Cascaded Thermoacoustic Devices
                                               Water-Soluble Polymers for Recovery of
    lated Reflectance                             Metals from Solids                       Gavrilov, Eugene (CTN-5)
 Fuel Injector Utilizing Plamsa Activation     Process for the Displacement of Cyanide      Network Topology Mapper
 Long-Range, Full Duplex, Modulated-              Ions from Metal-Cyanide Complexes
    Reflector Cell Phone for Voice/Data                                                    Germann, Timothy (T-12)
    Transmission                                                                            EpiCast, Version 1.0

22                                                                                                  2007 Technology Transfer Awards
Outstanding Innovation                                                                             Los Alamos National Laboratory

Goddard, Greg (B-9)                           Harker, William (N-1)                       High Critical Current Superconducting
 Ultrasonic Analyte Concentration and          International Neutron Coincidence            Tapes
   Application in Flow Cytometry                  Counting (INCC) , Version 3.0031       Hollingsworth, Jennifer (C-PCS)
                                               NCCWIN (English Version)
Gohdes, Joel (C-SIC)                                                                      Optical Amplifiers and Lasers
                                               Neutron Coincidence Counting for Win-
 Water-Soluble Polymers and Composi-                                                     Horley, Earl (ISR-4)
                                                  dows (Russian Version) (NCCWIN) ,
   tions Thereof                                                                          Mechanical Drawings for Super-High
                                                  Version 1.3
Gottesfeld, Shimshon (MPA-11)                  SuperHENC Neutron Coincidence Code           Efficiency Neutron Coincidence
 Preventing CO Poisoning in Fuel Cells            (Super HENC), Version 1.0                 (SuperHENC)
 Flow Channel Device for Electrochemical                                                 Howat, andrew (X)
                                              Havrilla, George (C-CDE)
    Cells                                                                                 SABRINA
                                               Method and Apparatus for Measuring
 Catalyst Inks and Method of Application
                                                  Binding Constants                      Hsu, Hsiao-Hua (P-24)
    for Direct Methanol Fuel Cells
                                               Method for Detecting Binding Events        Neutron Dose Equivalent Meter
 Methanol Sensor Operated in Driven
                                                  Using Micro-X-Ray Fluorescence
    Mode                                                                                 Hunke, Elizabeth (T-3)
                                                  Spectrometry
 Methanol Sensor Operated in Passive                                                      CICE v 4.0
                                               Flow Method and Apparatus for Screen-
    Mode
                                                  ing Chemicals Using Micro X-Ray        Huynh, My Hang Vo (DE-1)
 Air Breathing Direct Methanol Fuel Cell
                                                  Fluorescence                            Primary Explosives
Graves, Steven (B-9)                                                                      Explosive Complexes
                                              Henins, Ivars (P-24)
 Ultrasonic Analyte Concentration and                                                     Lead-Free Primary Explosives
                                               Large Area Atmospheric-Pressure
    Application in Flow Cytometry
                                                  Plasma Jet                             Ianakiev, Kiril (N-1)
 A System and Method for Measuring
                                               Processing Materials Inside an Atmo-       MiniGrand Family of Software
    Particles in a Sample
                                                  spheric-Pressure Radiofrequency Non-
Groves, James (MPA-STC)                           thermal Plasma Discharge               Jia, Quanxi (MPA-STC)
 Substrates Structure for Growth of            Atmospheric Pressure Plasma Etching        Improved Buffer Layer Compound for
   Highly oriented and/or Epitaxial Lay-          Reactor                                    Coated Conductors
   ers Thereon                                 Combined Plasma/Liquid Cleaning of         Substrates Structure for Growth of
                                                  Substrates                                 Highly oriented and/or Epitaxial Lay-
Guthrie, George (SPO-FE)                                                                     ers Thereon
 Detection of Alkali-Silica Reaction Swell-   Herrmann, Hans (P-24)                       Polymer-Assisted Deposition of Films
   ing in Concrete by Staining                 Atmospheric-Pressure Plasma Decon-         Structure for Improved High Critical
 Detection of Concrete Deterioration by           tamination/Sterilization Chamber           Current Densities in YBCO
   Staining                                    Processing Materials Inside an Atmo-       High-Rate Buffer Layer for IBAD MgO
                                                  spheric-Pressure Radiofrequency Non-
Habbersett, Robert (B-9)                                                                     Coated Conductors
                                                  thermal Plasma Discharge                Polymer-Assisted Aqueous Deposition of
 A System and Method for Measuring
                                               Atmospheric Pressure Plasma Etching           Metal Oxide Films
    Particles in a Sample
                                                  Reactor                                 Architecture for High Critical Current
Halbig, James (N-1)                                                                          Superconducting Tapes
                                              Hicks, Robert (P)
 MiniGrand Family of Software                                                             Preparation of Energy Storage Materials
                                               Deposition of Coatings Using an Atmo-
Hall, Simon (C-SIC)                               spheric Pressure Plasma Jet             High Critical Current Superconducting
 Reversible Electro-Optic Device Employ-       Large Area Atmospheric-Pressure               Tapes
   ing Aprotic Molten Salts and Method            Plasma Jet                              Method for Preparation of Semiconduc-
 Radiofrequency Attenuator and Method                                                        tive Films
                                              Hiskey, Michael (DE-1)
Hamada, Michael (CCS-6)                        Primary Explosives                        John, Kevin (C-IIAC)
 Optimizing the Availability of a Buffered                                                Fluorescent Beryllium Detection
                                              Holesinger, Terry (MPA-STC)
   Industrial Process                                                                    Johnson, Jeffrey (HPC-3)
                                               Architecture for High Critical Current
Hansen, Walter (N-4)                             Superconducting Tapes                    SABRINA
 MiniGrand Family of Software

2007 Technology Transfer Awards                                                                                                23
Los Alamos National Laboratory                                                                              Outstanding Innovation

Jones, Philip (T-3)                         Kwiatkowski, Christopher (IAT-2)             Mahan, Cynthia (C-DO)
 CICE v 4.0                                  Ultrasonic Analyte Concentration and         Flow Method and Apparatus for Screening
                                               Application in Flow Cytometry                 Chemicals Using Micro X-Ray Fluores-
Kaduchak, Gregory (B-9)
                                                                                             cence
 Ultrasonic Analyte Concentration and       Lamartine, Bruce (MST)
   Application in Flow Cytometry             Ultrahigh, Vacuum Focused, Ion Beam         Mann, Grace (C-SIC)
 Acoustic Concentration of Particles in        Micromill and Articles Therefrom           Method for Detecting Binding Events
   Fluid Flow                                Depth Enhancement of Ion Sensitized            Using Micro-X-Ray Fluorescence Spec-
 Apparatus for Separating Particles Uti-       Data                                         trometry
   lizing Engineered
                                            Less, Richard (MST-6)                        Marczak, Stanislaw (WES-EDA)
 Apparatus and Method for Remote, Non-
                                             Deposition Head for Laser                    Nitrate Reduction
   invasive Characterization of Struc-
                                             Multiple Feed Powder Splitter                Electrochemical Reduction of Nitrate in the
   tures and Fluids Inside Containers
                                             Rotary Powder Feed Through Apparatus            Presence of an Amide
 Cyliindrical Acoustic Levitator/Concen-
                                             Multiple Feed Powder Splitter
    trator Having Non-circular Cross-                                                    Martin, John (B-9)
                                             Rotary Powder Feed Through Apparatus
    section                                                                               Ultrasonic Analyte Concentration and
                                            Lewis, Gary (MST-6)                             Application in Flow Cytometry
Kelley, Thomas (CCN-12)
                                             Laser Production of Articles from Powders
 PC/FRAM, Version 2.3                                                                    Martin, Richard (P-25)
                                             Deposition Head for Laser
 PC/FRAM, Version 3.3                                                                     Acoustic Cryocooler
                                             Multiple Feed Powder Splitter
 PC/FRAM, Version 3.4
                                             Rotary Powder Feed Through Apparatus        Martinez, Rodolfo (B-8)
 PC/FRAM, Version 4.3
                                             Controlled Laser Production of Elongated     Synthesis of [2H1, 13C], [2H2, 13C] and [2H3,
Kelly, Patrick (CCS-3)                          Articles from Particulates                  13
                                                                                               C] Methylarl Sulfones and Sulfoxides
 Quality Assessment, Restoration and         Multiple Feed Powder Splitter                Synthesis of [2H1, 13C], [2H2, 13C] and
   oCr. (QUARC)                              Rotary Powder Feed Through Apparatus           [2H3, 13C]Methylaryl Sulfides
Kim,Yong Ho                                 Lewis, Cris (C-CDE)                           Synthesis of Labelled Oxalic Acid Deriva-
 Field Enhanced Electrodes for Additive      Flow Method and Apparatus for Screening        tives
    Injection Non-thermal Plasma (NTP)          Chemicals Using Micro X-Ray Fluo-         Synthesis of Isotopically Labeled D or L
    Processor                                   rescence                                    [13C,2H] Glycerols
                                                                                          Synthesis of 2H- and 13C- Substituted
Klimov, Victor (C-PCS)                      Li, Alexander (MST)                             Dithanes
 Nanocrystal Structures                      Polymer-Assisted Aqueous Deposition of
 Optical Amplifiers and Lasers                  Metal Oxide Films                        Martz, Harry (D-1)
                                                                                          Optimizing the Availability of a Buffered
Klosteruer, Shirley (N-4)                   Li, Lin Song (MST)                              Industrial Process
 MiniGrand Family of Software                Preparation of Energy Storage Materials
                                             Method for Preparation of Semiconductive    Matias, Vladimir (MPA-STC)
Koscielniak, Michael (D-6)                                                                Use of High Current Density Electropolish-
                                                Films
 Graphical Input Aggregate Control                                                          ing for the Preparation of Very Smooth
   (GIAC)                                   Lin, Yuan (MST)                                 Substrate Tapes for Coated Conductor
                                             Polymer-Assisted Deposition of Films           Applications
Krick, Merlyn (N)
 International Neutron Coincidence          Lipscomb, William (T-3)                      McBranch, Duncan (C)
    Counting (INCC) , Version 3.0031         CICE v 4.0                                   Method for Detecting Biological Agents
 NCCWIN (English Version)
                                            Lunsford, James (P-14)                       McCleskey, Thomas (MPA-MC)
 Neutron Coincidence Counting for Win-
                                             Offset Stabilizer for Comparator Output      Fluorescent Beryllium Detection
    dows (Russian Version) (NCCWIN) ,
    Version 1.3                             Maas, Lynn (D-6)                              Reversible Electro-Optic Device Employing
 Cosmic-Ray Neutron Background Reduc-        Graphical Input Aggregate Control               Aprotic Molten Salts and Method
    tion Using Localized Coincidence Veto      (GIAC)                                     Electrolytes for Electrooptic Devices Com-
    Neutron Counting                                                                         prising Ionic Liquids
                                                                                          Polymer-Assisted Deposition of Films


24                                                                                                2007 Technology Transfer Awards
Outstanding Innovation                                                                            Los Alamos National Laboratory

 Extension to MXRF IP Portfolio               Tailorable Rapid Acquisition and Visu-    Qian, Jiang (LANSCE-LC)
 Reversible Electro-Optic Device Employ-         alization Software (TRAViS), Version    Diamond-Silicon Carbide Composite and
    ing Aprotic Molten Salts and Method          1.0 (formerly known as ORCA PC)           Method for Preparation
 Electrochromic, Salts, Solutions and
                                             Naud, Darren (DX-2)                        Quist, Daniel (IAT-2)
    Devices
                                              Lead-Free Electric Match Compositions      Network Quarantine Code
 Radiofrequency Attenuator and Method
                                             Neagley, Daniel (ISR)                       Network Topology Mapper
McGhee, John (CCS-4)
 ATTILA
                                              Identification Coding Schemes for Modu-   Reagor, David (MPA-STC)
                                                 lated Reflectance                       Underground Radio
Melton, Sheila (N-2)                          Long-Range, Full Duplex, Modulated-        Narrowband High Temperature Supercon-
 Combined Thermal/Epithermal Neutron             Reflector Cell Phone for Voice/Data       ducting Receiver for Low Frequency
    (CTEN-FIT EXE), Version 1.0                  Transmission                              Radio Waves
 LIST-LIB (object library), Version 1
                                             Neutzler, Jay (T-DO)                       Reass, Pamela (ISR-4)
Menlove, Howard (N-1)                         Annular Feed Air Breathing Fuel Cell       MiniGrand Family of Software
 Electrical Drawings for Super-High Effi-       Stack
    ciency Neutron Coincidence (Super-
                                                                                        Reed, Theodore (D-6)
                                             Nolan, John (B-2)                           Graphical Input Aggregate Control
    HENC)
                                              DNA Base Mismatch Detection Using            (GIAC)
 Mechanical Drawings for Super-High
                                                Flow Cytometry
    Efficiency Neutron Coincidence
                                              DNA Polymorphism Identity Determina-
                                                                                        Ren, Xiaoming (MPA-11)
    (SuperHENC)                                                                          Flow Channel Device for Electrochemical
                                                tion Using Flow Cytometry
 Cosmic-Ray Neutron Background Reduc-                                                       Cells
    tion Using Localized Coincidence Veto    Olsher, Richard (RP-2)                      Air Breathing Direct Methanol Fuel Cell
    Neutron Counting                          Neutron Dose Equivalent Meter              Catalyst Inks and Method of Application
                                              Proton Recoil Scintillator Neutron REM        for Direct Methanol Fuel Cells
Migliori, Albert (MPA-NHMFL)
                                                 Meter                                   Methanol Sensor Operated in Driven
 Intrinsically Irreversible Heat Engine
                                             Olson, Jeffrey (MPA)                           Mode
Mikhailovski, Alexandre (C)                                                              Methanol Sensor Operated in Passive
                                              Tapered Pulse Tube for Pulse Tube
 Optical Amplifiers and Lasers                                                              Mode
                                                 Refrigerators
Milewski, John (MST-6)                                                                   Air Breathing Direct Methanol Fuel Cell
                                             Park, Jaeyoung (P-24)
 Controlled Laser Production of Elongated
                                              Processing Materials Inside an Atmo-      Robison, Thomas (C-CDE)
   Articles from Particulates                                                            Water-Soluble Polymers and Composi-
                                                 spheric-Pressure Radiofrequency
Miller, Thomasin (C-ACS)                         Nonthermal Plasma Discharge               tions Thereof
 Method and Apparatus for Measuring                                                      Water-Soluble Polymers for Recovery of
                                             Parker, Robert (N-4)                          Metals from Solids
    Binding Constants
                                              MiniGrand Family of Software               Water-Soluble Polymers for Recovery of
 Flow Method and Apparatus for Screen-
    ing Chemicals Using Micro X-Ray          Pautz, Shawn (CCS-4)                          Metal Ions from Aqueous Streams
    Fluorescence                              ATTILA                                     Water-Soluble Polymers and Composi-
                                                                                           tions Thereof
Minogue, Edel (C-CDE)                        Pelowitz, David (N-4)
 Fluorescent Beryllium Detection              Falcon, Version 2                         Rodgers, John (HSR-4)
                                                                                         Apparatus Having Reduced Background
Moody, David (RD)                            Platts, David (P-21)                           for Measuring Radiation Activity in
 Method of Using 5, 10, 15, 20-Tetrakis(4-    Identification Coding Schemes for Modu-       Aerosol Particles
   Carboxyphenyl) Porphine                       lated Reflectance                       Quick-Change Filter Cartridge
Naivar, Mark (B-9)                           Prime, Michael (WT-2)                       Elbow Mass Flow Meter
 Open Reconfigurable Cytometric Acquisi-      System and Method for Measuring            Alpha-Environmental Continuous Air
   tion System (ORCAS DSP), Version 1.0         Residual Stress                             Monitor Inlet
 Miniature Cytometric Acquisition System                                                Romero, Amos (LANSCE-6)
   (MiCAS DSP), Version 1.0                                                              MiniGrand Family of Software

2007 Technology Transfer Awards                                                                                              25
Los Alamos National Laboratory                                                                               Outstanding Innovation

Rosocha, Louis (P-24)                         Atmospheric Pressure Plasma Etching          Stutz, Roger (IAT-DO)
 Nonthermal Plasma Processor Utilizing          Reactor                                     Ultrahigh, Vacuum Focused, Ion Beam
    Additive Gas Injection and/or Gas         Combined Plasma/Liquid Cleaning of              Micromill and Articles Therefrom
    Extraction                                  Substrates
                                                                                           Sweet, Martin (ISR-4)
 Fast-Pulse Nonthermal Plasma Processor      Shera, Brooks (P-21)                           MiniGrand Family of Software
 Field Enhanced Electrodes for Additive       Ordered Transport and Identification of
    Injection Non-thermal Plasma (NTP)                                                     Swift, Gregory (MPA-10)
                                                Particles
    Processor                                                                               Intrinsically Irreversible Heat Engine
 Fuel Injector Utilizing Plasma Activation   Silks III, Louis (B-8)                         Acoustic Cryocooler
                                              Synthesis of [2H1, 13C], [2H2, 13C] and       Tapered Pulse Tube for Pulse Tube
Ryan, Robert (CS-OCS-4)                         [2H3, 13C] Methylarl Sulfones and              Refrigerators
 Work Package Generator (WPG), Ver-             Sulfoxides                                  Pulse Tube Refrigerator with Variable
   sion 1.0                                   Synthesis of [2H1, 13C], [2H2, 13C] and          Phase Shift
Salazar, Steven (ISR-4)                         [2H3, 13C] Methylarl Sulfones Methy-        Traveling-Wave Device with Mass Flux
 MiniGrand Family of Software                   laryl Sulfides                                 Suppression
                                              Synthesis of 2H- and 13C-Substituted          Cascaded Thermoacoustic Devices
Salzman, Gary                                   Dithanes                                    Circulating Heat Exchangers for Oscillat-
 Ultrasonic Analyte Concentration and                                                          ing-Wave Engines and Refrigerators
   Application in Flow Cytometry             Sinha, Dipen (MPA-11)
                                              Noninvasive Characterization of a Flow-      Takeda, Harunori (X)
Sampson, Thomas (N-1)                           ing Multiphase Fluid                        Phase and Radial Motion in Ion Linear
 PC/FRAM, Version 4.3                         Ultrasonic Analyte Concentration and            Accelerators (PARMELA)
 PC/FRAM, Version 3.3                           Application in Flow Cytometry
 PC/FRAM, Version 3.4                                                                      Terwilliger, Thomas (B-9)
                                              Apparatus and Method for Comparing            RESOLVE, Version 2.0
 PC/FRAM, Version 2.3                           Corresponding Acoustic Resonances in        SOLVE, Version 2.0
Sandoval, Darryl (CTN-5)                        Liquids                                     SOLVE, Version 1.0
 Network Quarantine Code                      Ultrasonic Characterization of Single         RESOLVE, Version 1.0
                                                Drops of Liquids                            Likelihood-Based Modification of Experi-
Sauer, Nancy (INST-OFF)                       Noninvasive Method for Determining the
 Water-Soluble Polymers for Recovery of                                                        mental Crystal Structure Electron
                                                Liquid Level and Density Inside of a           Density Maps
    Metals from Solids                          Container
 Process for the Displacement of Cyanide                                                    Maximum Likelihood Density Modifica-
                                              Noninvasive Identification of Fluids by          tion by Pattern Recognition of Struc-
    Ions from Metal-Cyanide Complexes            Swept-Frequency Acoustic Interfer-            tural Motifs
Schmidt, Jurgen (B-9)                            ometry                                     Method for Removing Atomic-Model Bias
 Synthesis of [2H1, 13C], [2H2, 13C] and      Apparatus and Method for Remote, Non-            in Macromolecular Crystallography
   [2H3, 13C] Methylarl Sulfones and             invasive Characterization of Structures
   Sulfoxides                                    and Fluids Inside Containers              Thomas, Sharon (MPA-11)
                                                                                            Catalyst Inks and Method of Application
Seagraves, David (RP-2)                      Smith, Barbara (C-CSE)                           for Direct Methanol Fuel Cells
 Proton Recoil Scintillator Neutron REM       Water-Soluble Polymers for Recovery of
    Meter                                       Metals from Solids                         Turner, Cameron (PMT-4)
                                              Water-Soluble Polymers for Recovery of        Hyperdimensional Performance Maps
Selwyn, Gary (P-24)                             Metal Ions from Aqueous Streams               (HyPerMaps), Version 1.10.3.23
 Atmospheric-Pressure Plasma Jet
                                             Snyder, Hans (N-2)                            Unkefer, Clifford (B-8)
 Deposition of Coatings Using an Atmo-
                                              Atmospheric Pressure Plasma Etching           Synthesis of [2H1, 13C], [2H2, 13C] and
    spheric Pressure Plasma Jet
                                                Reactor                                       [2H3, 13C] Methylarl Sulfones and
 Large Area Atmospheric-Pressure
                                                                                              Sulfoxides
    Plasma Jet                               Son, Steven (DE-6)                             Synthesis of Labelled Oxalic Acid Deriv-
 Processing Materials Inside an Atmo-         Lead-Free Electric Match Compositions           atives
    spheric-Pressure Radiofrequency
    Nonthermal Plasma Discharge              Stan, Liliana (MPA-STC)                        Synthesis of Isotopically Labeled D or L
                                              Architecture for Coated Conductors              [13C,2H] Glycerols

26                                                                                                  2007 Technology Transfer Awards
Outstanding Innovation                                                                           Los Alamos National Laboratory

 Synthesis of 2H- and 13C- Substituted     Wang, Hsing-Lin                            West, James (X)
   Dithanes                                 Method for Detecting Biological Agents     SABRINA
Vacarro, Henry (N)                         Ward, Michael (B)                          Wheatley, John (C)
 WISDOM & SENSE (W&S)                       Acoustic Concentration of Particles in     Intrinsically Irreversible Heat Engine
Van De Sompel, Herbert (STBPO-                Fluid Flow
                                                                                      White, Paul (B-7)
                                            Apparatus for Separating Particles Uti-
RL)                                           lizing Engineered
                                                                                       DNA Base Mismatch Detection Using
 Blackbox, Version 1.0                                                                   Flow Cytometry
 Usage Based Indicators to Assess the      Waring, Todd (CCS-4)                        DNA Polymorphism Identity Determina-
    Impact of Scholarly                     ATTILA                                       tion Using Flow Cytometry
Van Riper, Kenneth (X)                     Warner, Benjamin (MPA-MC)                  Whitten, David (B)
 SABRINA                                    Fluorescent Beryllium Detection            Method for Detecting Biological Agents
                                            Reversible Electro-Optic Device Employ-
Vasilik, Dennis (HSR)                                                                 Wilson, Mahlon (MPA-11)
                                               ing Aprotic Molten Salts and Method
 Neutron Dose Equivalent Meter                                                         Annular Feed Air Breathing Fuel Cell
                                            Method and Apparatus for Measuring
                                                                                         Stack
Vasquez-Dominquez, Jose (MPA-                  Binding Constants
                                                                                       Fuel Cell with Interdigitated Porous
STC)                                        Electrolytes for Electrooptic Devices
                                                                                         Flow-Fields
 Underground Radio                             Comprising Ionic Liquids
                                                                                       Fuel Cell Membrane Humidification
                                            Extension to MXRF IP Portfolio
Vo, Duc T (N-1)                                                                        Annular Feed Air Breathing Fuel Cell
                                            Reversible Electro-Optic Device Employ-
 PC/FRAM, Version 4.3                                                                    Stack
                                               ing Aprotic Molten Salts and Method
                                                                                       Fuel Cell with Metal Screen Flow-Field
Waldo, Geoffrey (B-9)                       Method for Detecting Binding Events
                                                                                       Composite Bipolar Plate for Electro-
 Self-Assembling Split-Fluorescent Pro-        Using Micro-X-Ray Fluorescence
                                                                                         chemical Cells
    tein Systems                               Spectrometry
                                                                                       Ambient Pressure Fuel Cell System
 Circular Permutant GFP Insertion Fold-     Electrochromic, Salts, Solutions and
    ing Reporters                              Devices                                Young, Lloyd (ISR-6)
 Protein Subcellular Localization Assays    Flow Method and Apparatus for Screen-      Phase and Radial Motion in Electron
    Using Split                                ing Chemicals Using Micro X-Ray           Linear Accelerators (PARMELA),
 Method for Determining and Modifying          Fluorescence                              Version 3.0
    Protein/Peptide                        Weisbrod, Kirk (AET-5)                     Zawodzinski, Christine (MPA-11)
 Protein-Protein Interaction Detection      Corrosion Test Cell for Bipolar Plates     Fuel Cell with Metal Screen Flow-Field
    System Using
 Method for Determining and Modifying      Wells, Cyndi (IAT-1)                       Zelenay, Piotr (MPA-11)
    Protein/Peptide                         Method and Apparatus for Measuring         Catalyst Inks and Method of Application
                                               Binding Constants                         for Direct Methanol Fuel Cells
Wang, Haiyan (MPA-STC)                      Flow Method and Apparatus for Screen-
 Improved Buffer Layer Compound for                                                   Zhao, Yusheng (LANSCE-LC)
                                               ing Chemicals Using Micro X-Ray
   Coated Conductors                                                                   Diamond-Silicon Carbide Composite and
                                               Fluorescence
 Architecture for Coated Conductors                                                      Method for Preparation




2007 Technology Transfer Awards                                                                                                 27
Los Alamos National Laboratory                                                           Outstanding Innovation


Fiscal Year 2007                 Next Generation Hand Held               would be able to address both
                                 Multiplicity Register (HHMR)            applications and would be field
Executed Cooperative                                                     portable, require minimal sample
Research and                     Matthew Newell (N-1)                    preparation, provide carbon depth
Development                      Jointly develop and commercial-         profiling with a resolution of ~1
                                 ize the portable multiplicity shift     mm, require only a few minutes
Agreements (CRADAs)              register and subsequent unattended      per sample, be fully automated,
                                 mode shift register technology          and operate without consumable
                                 having the capability for high          reagents. The CRADA partner and
                                 speed neutron data acquisition          Los Alamos National Laboratory
                                 and multiplicity analysis. This next    (LANL) propose development of
                                 generation shift register would         the laser-induced breakdown spec-
                                 allow application of existing and       troscopy (LIBS) technique as a low-
                                 potentially new analysis techniques     cost, field portable, and automated
                                 to be applied to a wider range of       method for quantifying carbon in
                                 applications and a greater range of     soils and subsoils that will have
                                 plutonium bearing material types.       significant commercial potential.
                                 LANL will support the solution of
                                 certain technical design and testing    2G Superconductor
                                 issues. The Participant will support    Technology with
                                 technical, engineering, and manu-       Nanoengineered YBCO Films
                                 facturing solutions that are required
                                 to achieve a viable commercial          Leonardo Civale (MPA-STC)
                                 product.                                Coated conductor (CC) technol-
                                                                         ogy (superconductor wires based
                                 The Laser Induced                       on yttrium barium copper oxide
                                 Breakdown Spectroscopy                  [YBCO] films) is maturing rapidly.
                                 for Monitoring Carbon                   Wires hundreds of meters long
                                 Sequestration                           with critical current (Ic) exceeding
                                                                         100 A/cm width at liquid nitrogen
                                 Ronny Harris (EES-2)                    (T~77K) in the absence of applied
                                 Measurement of carbon in soils          magnetic fields have been demon-
                                 is important for determining the        strated. Reaching commercializa-
                                 capture of carbon and for charac-       tion level will still require large
                                 terizing soil productivity. The first   increases in Ic both in self-field
                                 objective is connected to monitor-      and in external fields, utilizing
                                 ing and verification of CO2 seques-     cost-efficient industrial production
                                 tration sites. The second can help      methods. The Los Alamos National
                                 guide effective land management         Laboratory/Superconductivity
                                 practices. Both would benefit from      Technology Center (LANL/STC)
                                 the development of fast, low-cost       has led the area of improving Ic
                                 sampling methods. The ideal ana-        through incorporation of BaZrO3
                                 lyzer for carbon in soil and subsoil    nanoparticles and fabrication of

28                                                                               2007 Technology Transfer Awards
Outstanding Innovation                                                                     Los Alamos National Laboratory

YBCO/CeO2 multilayers. The              (APE) and Moligo assays. The             handling, formulation, research and
Participant will build upon this suc-   CRADA Partner’s system and the           development of medical isotopes to
cess by utilizing their nanoparticle-   LANL assays have undergone               establish medically useful radiop-
generating suite of technologies to     extensive development and valida-        harmaceuticals.
explore even more effective pinning     tion and are being integrated for the
centers that can be economically        first time by the CRADA Partners.        Acoustic Drilling
combined with industrial scale          The final product will be a por-
                                                                                 Optimization and Nonlinear
CC processing. Specifically, Laser      table, low-cost, rapid, user-friendly
                                        genetic analysis system for commer-      Acoustic Reservoir Imaging
Assisted Molecular Beam and
Pulsed Arc Molecular Beam tech-         cial applications. Personnel could       Dipen Sinha (MPA-11)
nologies will be used to co-deposit     use the field device, with minimal
                                                                                 Investigating the use of LANL’s
a wide variety of nanoparticles with    training and expense, to perform
                                                                                 advanced acoustic sensor technol-
YBCO.                                   testing for the presence of infectious
                                                                                 ogy in a whole range of applica-
                                        diseases and biowarfare agents and
                                                                                 tions related to the optimization
                                        have definitive results within thirty
Muon Tomography for                                                              of drilling efficiency, oil produc-
                                        minutes or less.
Detection of Potential Non-                                                      tion, and reservoir management
Nuclear Threat Objects                                                           in deep wells. This is important
                                        Development and Evaluation               from the perspective of improving
Chris Morris (P-25)                     of Next Generation                       well yields and hence to national
Engage in collaborative research        Gallium-68 Targeted                      energy security.
to refine existing technologies that    Radiopharmaceuticals
have broad applicability to home-                                                GMRS Bore Stress
land security applications, including   Kevin John (C-IIAC)
border and port inspections.            The CRADA Participant is a               Christopher Bradley (EES-11)
Investigating the use of LANL’s         national resource for the develop-       The objective of the collaboration is
muon tomography technology to           ment of applications for unique          to provide the CRADA Participant
detect and identify potential nuclear   medically useful radioisotopes           with a theoretical material model
threat objects. The goal of this        available from Los Alamos National       for reservoir rock that reflects the
research and development project is     Laboratory (LANL) Isotope Pro-           observed behavior of the rock
to develop a muon tomography sen-       duction Facility (IPF). The LANL         during deflation and inflation of
sor for this purpose.                   IPF is a beam spur on the LANL           the reservoir. Material models of
                                        linear accelerator (LINAC) that will     this type are not typically handled
                                        produce unique gamma emitting            with purely elastic rock models.
Multipathogan Microarray                and positron emitting (PET) unique       Los Alamos National Laboratory
Development                             isotopes that until now have not         will develop an invariant form of
                                        been available in sufficient quanti-     a plasticity model for rock. LANL
Murray Wolinsky (B-7)
                                        ties for product development. The        will develop and test a theoretical
The CRADA project will integrate        CRADA Participant, the University        material model using analytical
and evaluate the CRADA Partner’s        of New Mexico, New Mexico Center         and computational methods and
microfluidic controlled microar-        for Isotopes in Medicine, a research     provide guidance to the CRADA
ray platform with the Los Alamos        center of the College of Pharmacy,       Participant to test this model in the
National Laboratory’s (LANL)            Health Sciences Center, brings           laboratory.
Allele-specific Primer Extension        UNM’s long-standing expertise in

2007 Technology Transfer Awards                                                                                      29
Los Alamos National Laboratory                                                                   Outstanding Innovation


LabView Version of                      effort is a lab-scale test on typical   Elemetric Magnetron
PeakDoctor Software                     industrial process streams identified
                                        by the CRADA participant with the
                                                                                Power Supply
Scott Garner (N-2)                      goal of providing sufficient techni-    Gregory Dale (ISR-6)
Cooperate in the further develop-       cal data to carry out an economic       The work under this project will
ment of the PeakDoctor program          analysis of the process change by       consist of the development of a
initially created by LANL. The          the CRADA participant. This would       preproduction prototype 200 watt,
PeakDoctor software is a gamma          include both capital equipment sav-     2.45 GHz Microwave Power Supply
spectroscopy analysis tool useful       ings as well as anticipated energy      subassembly, including an elec-
for providing very accurate peak fit    savings due to lower separation         trically matched and integrated
analysis on a wide range of gamma       temperatures.                           plasma chamber.
spectra (HPGe). The Participant has
recent experience commercializing       Mechanical Polishing of                 Construction of Prototype
LANL-developed technology, techni-      Substrates for Coated
cal expertise in the area of gamma
                                                                                Muon Tomography Scanner
                                        Conductors                              for Detection of Potential
spectroscopy, and has established
relations with the technical experts    Vladimir Matias (MPA-STC)               Threat Objects
from LANL’s NWIS-SWO and                This project involves evaluating the    Chris Morris (P-25)
N2 groups.                              CRADA Participant’s proprietary         Investigate the use of LANL’s muon
                                        polishing process for use in coated     tomography technology to detect
High Speed Wavelength AO                conductors fabricated using ion-        and identify potential threat objects.
Turning for CO2 Heterodyne              beam assisted deposition (IBAD)         The goal of this research and
Remote Sensing of Aerosols              textured templates and high temper-     development project is to develop a
                                        ature superconductors (HTS). For this   muon tomography scanner for this
George Busch (C-CDE)                    purpose, the Participant will supply    purpose.
Work to be performed under this         a number of mechanically polished
                                        metal substrates and mechanically
CRADA involves the development                                                  Brake Pad Defect Detection
of two wavelength agile CO2 lasers      polished layers on top of metal
                                        substrates. LANL will deposit IBAD      Dipen Sinha (MPA-11)
that will be locked to each other in
frequency at high pulse repetition      templates and HTS layers using          Automobile brake pads may have
rates (>200 Hz). Waveguide lasers       LANL’s coated conductor technology      defects such as cracks or delamina-
will be used for compactness, and       on these polished materials. Further-   tions during manufacturing. These
high pulse repetition rates.            more, LANL will characterize coated     defects need to be detected and
                                        conductor tapes made with MIPOX         the defective unit removed before
                                        polished substrates with electrical     the product is ready for market.
Hollow Fiber Separations                measurements of critical currents,      The current approach to detecting
Dali Yang (MST-7)                       magnetic field dependence thereof,      defects involves manual examina-
                                        and ac losses. LANL will also per-      tion of the brake pads that is both
Explore the operational parameters
                                        form electron microscopy on these       subjective and slow. The proposed
and economic feasibility of replacing
                                        samples.                                work will evaluate an acoustic tech-
the conventional tray-type distilla-
tion towers in petroleum refineries                                             nique for defect detection that can
with hollow fiber membranes. The                                                provide an automated and rapid
                                                                                detection of brake pad defects.
30                                                                                      2007 Technology Transfer Awards
Outstanding Innovation                                                           Los Alamos National Laboratory

Detection of foreign Bodies              Oil and Gas Environmental
in Beverages                             Protection Science and
Dipen Sinha (MPA-11)
                                         Technology Program
During the beverage bottling pro-        Cathy Wilson (EES-DO)
cess, small particulate matter such      Develop and apply a diverse suite
as microscopic pieces of pipe mate-      of environmental protection science
rial, rubber O-ring, and dried up liq-   and technology tools under this
uid residue may fall into the bottle.    CRADA project to ensure environ-
Filters are not always effective in      mental protection at Chevron oil
preventing such contamination.           and gas sites, with particular atten-
Although these particulate matters       tion to unconventional fuel resource
can be a few microns in size, they       production (e.g., oil shale) sites.
tend to coalesce and grow to visible
sizes. Normally, this is detected
                                         Combustion-Powered
during visual inspection of bottles
that are transparent. Such visual        Thermoacoustic Natural Gas
inspection is a slow process and not     Liquefaction
perfect. The purpose of this effort      Gregory Swift (MPA-10)
is to explore acoustic and other
techniques to determine whether          Develop a 20,000 gallon/day
such foreign objects can be detected     combustion-powered thermoacous-
noninvasively.                           tic natural gas liquefier. Heavier
                                         hydrocarbons will be condensed
                                         and removed in higher-temperature
Software Development                     stages in the cascade refrigeration
for Design and Operation                 system. We seek a package size
of Prototype Muon                        small enough to transport by rail
Tomography Scanner                       without a special permit, a low pro-
                                         jected manufacturing cost once the
Michael Sossong (X-1-TA)                 design is complete, and an energy
Investigating the use of LANL’s          efficiency such that 80% to 85% of a
muon tomography technology to            clean gas stream is liquefied while
detect and identify potential threat     15% to 20% is burned. This repre-
objects. The goal of this research and   sents a dramatic increase in power
development project is to develop        (more than a factor of 40) above pre-
a muon tomography sensor for this        vious thermoacoustic equipment,
purpose.                                 and a significant increase in energy
                                         efficiency.




2007 Technology Transfer Awards                                                                            31
Los Alamos National Laboratory                                                            Outstanding Innovation


Fiscal Year 2007                 Research Library – Mellon                prior experience in applying these
                                 Grant                                    techniques to the characterization of
Work for Others –                                                         various bacterial DNAs, including
Non-Federal Agreements           Johan Bollen (STBPO-RL)                  the DNA of C. botulinum.
Executed                         The project will benefit the scholarly
                                 community involved with usage-           Integration of RF/EO
                                 based evaluation metrics by the          Technologies for Electronics
                                 definition of a formal model of the
                                                                          Detection and Location
                                 scholarly communication process,
                                 lessons learned from the generation      Clifford Fortgang (IAT-2)
                                 of a large-scale reference data set,     The Sponsor has been briefed on
                                 the definition and validation of a       several LANL technologies relevant
                                 range of usage-based scholarly eval-     to the detection and defeat of IEDs.
                                 uation metrics, the formulation of a     The Sponsor believes, and LANL
                                 set of guidelines on their semantics     agrees, that if these technologies can
                                 and a resulting taxonomic model of       be integrated, then the integrated
                                 the concept of scholarly status.         system will work better than the
                                                                          individual technologies working
                                 Molecular Characterization               separately. The objective of this
                                 of Clostridium Botulinum                 project is to demonstrate mul-
                                 and Related Isolates                     tiple LANL technologies working
                                                                          together as a system for detecting
                                 Karen Hill (B-7)                         IEDs. The transferring of data and
                                 The purpose of this Work Agree-          the ability of each technology to
                                 ment is to characterize by molecular     work well in the presence of the oth-
                                 DNA techniques approximately             ers without electrical interference
                                 1200 strains of Clostridium botu-        will be the greatest challenges.
                                 linum and related clostridia that
                                 have caused infant botulism in           The Feasibility Study of
                                 California or that are otherwise of      NDA Holdup Measurements
                                 interest to the California Depart-
                                                                          for the Rokkasho Uranium
                                 ment of Health Services (CDHS).
                                 This characterization will be done       Enrichment Plant
                                 using special DNA primers, probes,       Johnna Franco (N-1)
                                 techniques and equipment that
                                                                          This work involves the develop-
                                 LANL uniquely possesses. Molecu-
                                                                          ment of the nondestructive assay
                                 lar DNA techniques to be used
                                                                          (NDA) systems and techniques for
                                 include polymerase chain reaction
                                                                          the Rokkasho Uranium Enrichment
                                 (PCR), amplified fragment length
                                                                          Plant (REP) of JNFL. The study will
                                 polymorphism (AFLP), variable
                                                                          evaluate the technical approaches
                                 number tandem repeat (VTNR),
                                                                          for measuring the uranium process
                                 and regional gene sequencing of
                                                                          hold-up of the REP RE-1 facility that
                                 the toxin gene complex. LANL has
32                                                                                2007 Technology Transfer Awards
Outstanding Innovation                                                                      Los Alamos National Laboratory

is under the International Atomic        MCNPX Visual Editor                      Thermally-Driven Acoustic
Energy Agency (IAEA) safeguards          Support and Consulting                   Generator
inspection. The results of this work
will derive and improve knowledge        Gregg McKinney (X-3)                     Scott Backhaus (MPA-10)
and technology on nuclear material       The MCNPX Monte Carlo radia-             Thermoacoustic engines convert
control, accountancy, and verifica-      tion transport code is an extension      high-temperature heat into acoustic
tion to ensure efficient and effective   of MCNP4C to all particles and all       power which may then be con-
safeguards as required by IAEA.          energies, in addition to retaining the   verted into electrical power via a
                                         functionality of MCNP. It is widely      linear alternator. We will develop
Demonstration Run of                     used by universities, national           a prototype engine-generator,
                                         laboratories, and industry especially    designed to address a micro-cogen-
EPICAST
                                         to analyze accelerator target and        eration need for combined heat
Timothy Germann (T-12)                   health physics applications, space       and power at the residential level.
LANL will use its large-scale epide-     shielding, cosmic radiation effects      Requirements for this application
miological simulation model “Epi-        and medical cancer therapy—              are approximately 500–1000 watts
Cast” to predict the potential spread    especially using charged particle        capacity and 15% or better thermal
of pandemic influenza within the         beams. Considerable expertise is         efficiency, combined with extremely
United States for two scenarios: (1)     needed to run the code, and we           high reliability and minimal service
An unmitigated outbreak in which         often find that users benefit from       needs, comparable to present home
no medical or social interventions       supplementary support. By provid-        heating appliances. Los Alamos has
are employed; and (2) A situation        ing a consulting contract directly       unique abilities in the modeling
in which a heightened response           from the code developers in X-3, we      of thermoacoustic engines that are
level is activated, involving the        will be able to help users properly      crucial to the success of the project.
therapeutic and prophylactic use         install the code, provide training,
of antiviral drugs. The heightened       and consultation for specific prob-      Fluorescent Immunoassay
response level is that expected to be    lems. This is essential for proper       Development for PrPSc
achieved as a result of Raytheon’s       software management, which puts          Detection and Antemortem
proposed situational awareness           direct responsibility for the proper
                                         use of code upon the code develop-
                                                                                  Diagnosis of TSEs
network. Some exploratory studies
are anticipated for (2) to determine     ers, especially when customers are       Perry Gray (D-6)
necessary requirements for the situ-     involved in nuclear applications.        The work will improve the perfor-
ational awareness network to lead        We will also give customers access       mance of a fluorescence spectrom-
to successful containment. Movies        to the latest code Versions and keep     eter, and develop a new system
and data for each scenario will be       them fully apprised of bugs and          for use with existing FIA assays
provided to Raytheon, as well as the     fixes as they develop. Although          for ante-mortem testing of TSEs.
basic results of the exploratory stud-   the standard MCNP code is widely         The Sponsor does not have at his
ies. LANL involvement is required        used and considerable expertise is       disposal personnel within or in the
due to the unique capabilities of its    available outside the lab, the exten-    private industrial sector with the
copyrighted simulation model, as         sions provided by MCNPX are new          expertise to perform this task. Part
well as the high-performance com-        and quite specialized. We consider       of the work involves analyzing
puting resources required.               it essential that cost-effective and     the entire optical train of elements
                                         dedicated help be available directly     including the fluorescence source
                                         from the code developers.                and detection mechanisms of the

2007 Technology Transfer Awards                                                                                       33
Los Alamos National Laboratory                                                                     Outstanding Innovation

existing detection hardware. The         Pathogenesis of SIV in                   dwarfs have been recognized, L and
overall requirement is to increase       African Monkeys                          T dwarfs. There is strong evidence
the sensitivity of the apparatus by at                                            that the atmospheres of L dwarfs
least a factor of two while retaining    Ruy Ribeiro (T-10)                       harbor layers of iron and silicate
low sensitivity to scattered light.      The Tulane National Primate              clouds while the atmospheres of T
We will also develop an improved         Research Center was financed by          dwarfs are mostly cloudless. The
instrument, for use with FIA assays,     the National Institutes of Health to     transition between the two appears
with sensitivity and dynamic range       develop research in the area of non-     rather sudden. The mechanism of
applicable to antemortem TSE             pathogenic SIV infection. Part of        this transition is not well known
diagnosis.                               their objectives calls for a quantita-   and is a focus of this project. This
                                         tive understanding of viral dynam-       is an exciting field at the frontier of
Performance Prediction                   ics and immune system dynamics.          stellar astrophysics that is mak-
                                         Although the External Partner has        ing extensive use of data from
Adolfy Hoisie (CCS-1)                    full experimental capabilities, they     the Spitzer Space Telescope. One
Performance analysis, modeling           lack the expertise in this quantita-     unexpected discovery from this
and prediction of a computer code        tive approach to fulfill their pur-      space data is a flattening of the
(WRF) on a novel IBM-developed           poses. R. Ribeiro, at T-10, LANL,        spectrum of L dwarfs in the 8–10
parallel system architecture (PERCS).    has been working in this field for 7     micron range. We aim to under-
                                         years and understands the biologi-       stand how this can be modeled and
                                         cal tenets of the subject as well as     we strongly suspect that it is related
Thermoacoustic Converter
                                         being an expert in the modeling of       to the particle size distribution in
for Space Power                                                                   the cloud layers and the nature
                                         both viral infections and immune
Scott Backhaus (MPA-10)                  responses to them. The objective         (composition) of the particles. This
                                         of the project is to develop models      will provide new insights into the
Thermoacoustic engines convert
                                         for non-pathogenic SIV infection         cloud physics in brown dwarfs. It
high-temperature heat into acoustic
                                         in support of the experimental           has been recognized for some time
power which may then be con-
                                         research of the External Partner and     that the atmospheres of planets
verted into cooling power via a
                                         to help analyze the data that they       show disequilibrium abundances of
thermoacoustic refrigerator or into
                                         produce.                                 certain chemical species and there is
electrical power via a linear alter-
                                                                                  growing evidence that cool brown
nator. We will design a prototype
                                                                                  dwarfs share this phenomenon. An
engine-refrigerator-alternator com-      The Role of Dust and Non-
                                                                                  important focus of this work is the
bination to meet the electrical and      Equilibrium Chemistry in                 systematic modeling and study of
cooling needs of a conceptual space      the Atmospheres of L and                 this phenomenon.
probe to a planet whose surface          T Dwarfs as Constrained
temperature is higher than can be
tolerated by conventional solid-state
                                         by Spitzer IRS and IRAC                  Science Team Support for
electronics. Los Alamos has unique       Observations                             the Messenger Mission
abilities in the modeling and design     Didier Saumon (X-1 SMMP)                 David Lawrence (ISR-1)
of thermoacoustic engines, refrig-
                                         Brown dwarfs (BDs) are substellar        The objective of this work is to carry
erators, and associated components
                                         objects that represent the transition    out data reduction, analysis, and
that are crucial to the success of
                                         between stars and giant planets like     scientific studies with data from the
the project.
                                         Jupiter. Two spectral types of brown     MESSENGER neutron spectrometer

34                                                                                         2007 Technology Transfer Awards
Outstanding Innovation                                                                       Los Alamos National Laboratory

(MNS). While the Planetary Science        surveillance community. Thus, the        evolution of electrically heated
Institute (PSI) has scientific exper-     proposed project fits well within the    gases, and the modeling of self-
tise for understanding this data,         guidelines established for the goals     consistent high-voltage discharges
PSI is not equipped to carry out the      of the ISD.                              through gases.
detailed data reduction and analysis
tasks required for delivering the         SOA Framework-Tactical                   HTLN Automated Sample
scientific products to the MESSEN-
                                          Decision System                          Archival and Accessioning
GER mission. This expertise resides
at LANL and is based on a history         G. Loren Toole (D-4)
                                                                                   Systems
of understanding the MNS sensor           Raytheon wants to incorporate the        Tony Beugelsdijk (C-CDE)
in particular and planetary neutron       features and functionality of the        The objective for this Statement of
data in general.                          LANL-developed Scenario Library          Work is to prepare an overall feasi-
                                          Visualizer into programs and inter-      bility study for the UCLA/LANL
Influenza Sequence                        faces that it is developing for client   High Throughput Laboratory Net-
Management Data and                       use. The Scenario Library Visual-        work (HTLN) project’s automated
Analysis                                  izer (SLV) tool currently executes       sample archival and accessioning
                                          in a Visual Basic code environment       systems.
Catherine Macken (T-10)                   from ESRI ArcGIS 8.3. Raytheon
                                                                                   UCLA is under challenging sched-
The Influenza Sequence Database           has stated interest in migrating this
                                                                                   ule constraints to make this key
(ISD) was fully developed by LANL         code, in whole, to JAVA.
                                                                                   acquisition. The combination of
and is a database-driven web site,                                                 project knowledge, domain exper-
with extensive, and unique capabili-      Theory and Simulation                    tise, and key networks within the
ties for storage and analysis of influ-   of Laser Initiated Plasma                vendor community uniquely posi-
enza genetic and protein sequences.                                                tions LANL to perform this study
                                          Channel (LIPC) Experiments
The ISD is a large, mature project                                                 within the time constraints.
that has been partially supported         Mark Schmitt (X-1-PTA)
by the CDC (USA) to extend ISD            LANL will be providing theory
capabilities for supporting national
                                                                                   Physics-Based Prediction
                                          and simulation support to experi-
and international public health and                                                of Brand Transport in the
                                          ments being conducted at Ionatron,
research interests connected with         Inc. in Tucson, AZ. Since Ionatron
                                                                                   Context of Large Fires
influenza. If the customer did not        is mainly an experimental R&D            (Spotting)
appeal to LANL for this work, then        company, and owing to the complex
it would be necessary for the cus-                                                 Eunmo Koo (EES-2)
                                          multi-disciplinary physics associ-
tomer to establish their own data-                                                 LANL is uniquely qualified to per-
                                          ated with these experiments, they
base: such an undertaking would                                                    form this research due to its widely
                                          have requested LANL's assistance
be inefficient for both parties. This                                              recognized wildfire model, compu-
                                          in understanding the physical prin-
proposed project draws on the basic                                                tational resources, and expertise in
                                          ciples that are needed to optimize
expertise of the ISD, and covers pos-                                              science-based prediction of wildfire
                                          their experimental results. LANL
sible extensions of current capabili-                                              behavior.. Eunmo Koo is the perfect
                                          will be providing expertise in the
ties, designed in consultation with                                                candidate to do this work due to
                                          areas of ultra-short pulse laser
ISD staff, to serve the specialized                                                his understanding of fire brand
                                          propagation, laser filamentation and
data management and analysis                                                       dynamics and combustion as well
                                          ionization, radiation-hydrodynamic
needs of the influenza research and                                                as HIGRAD/FIRETEC. LANL has

2007 Technology Transfer Awards                                                                                        35
Los Alamos National Laboratory                                                                      Outstanding Innovation

developed HIGRAD/FIRETEC, a               samples and provide critical labora-     of recording systems. LANL person-
premier physics-based model for           tory capacity. The overall project       nel have developed software for
the prediction of continuous-spread       will facilitate rapid expansion to       de-glitching seismic signals and are
fire behavior which is recognized         multiple networked sites.                experts in methods for deconvolv-
as a world leader for this type of        LANL, as the technology provider,        ing instrument effects and in yield/
tool. Unfortunately, spotting is not      is complementary to UCLA School          source discrimination research,
currently incorporated in HIGRAD/         of Public Health. The UCLA School        which this data will support.
FIRETEC. Spotting transport phe-          is a premier R&D and educational
nomena and the nature of its strong       institution dedicated to the world-      Field Device for Avian
coupling to the environmental condi-      wide study of emerging infectious        Surveillance
tions are not well understood. This       disease. As such it has a far-reaching
lack of knowledge is especially true      surveillance charter and system in       Torsten Staab (C-CDE)
when the influences of the cou-           place to guide the technology devel-     Given the imminent threat of
pling between the atmosphere, fire,       opment and provide samples to            avian influenza developing into a
topography, and vegetation on the         the high throughput experimental         global epidemic, LANL proposes to
transport of the brands is considered.    capabilities that LANL will design       develop a specialized Version of its
This knowledge gap has a significant      and deliver. LANL has institutional      patented, multi-purpose sample col-
impact on the ability to anticipate       strengths in complex experimenta-        lection and tracking device for avian
risk, develop mitigation safety strate-   tion and systems, bioinformatics,        field surveillance. This multi-media,
gies, and manage fuels.                   high performance computing,              handheld sample collection and
                                          design of software architectures,        tracking device will enable ornithol-
High Speed High Volume                    quality assurance programs, and          ogists and others to rapidly collect
Laboratory Network for                    biological protocol development.         and disseminate avian surveillance-
Infectious Disease                                                                 related field data.
                                          Improvements to a Major                  The overall requirement calls for
Tony Beugelsdijk (C-CDE)
                                          Digital Archive of Seismic               the production and deployment of
Government agencies and expert                                                     several hundred avian field surveil-
                                          Waveforms from Nuclear
panels have recognized the need for                                                lance devices. UCLA cannot meet
laboratories capable of analyzing tens
                                          Explosions
                                                                                   these requirements without LANL’s
of thousands of biological samples        Howard Patton (EES-11)                   assistance, since the underlying core
per day that have hundreds of times                                                technology and software is LANL-
                                          The objective of this 3-year project
more capability than at present. This                                              owned. Given LANL’s pre-existing
                                          is to develop a digital archive of
project aims to develop a new high                                                 IP in this area and its in-house engi-
                                          high-quality useable seismograms
speed, high volume (high-through-                                                  neering experience and capabili-
                                          recorded at the Borovoye Observa-
put) laboratory capability that will                                               ties, only LANL can customize the
                                          tory (BRV) in northern Kazakhstan.
be linked in a network and operated                                                device for its intended use. UCLA
                                          BRV data were made available to
by several premier institutions. The                                               currently does not have the tech-
                                          western scientists in 2001, but the
automated, networked capability                                                    nical know-how and the produc-
                                          form of the data prevented wide
will make us stronger against natural                                              tion capabilities to adopt LANL’s
                                          usage in the seismological commu-
diseases and bioterrorist attacks. The                                             existing technology for its unique
                                          nity due to the presence of glitches
combination of high-throughput                                                     application.
                                          and incomplete knowledge of the
and automated systems will enable
                                          instrument responses for a number
processing of tens of thousands of

36                                                                                         2007 Technology Transfer Awards
Outstanding Innovation                                                                      Los Alamos National Laboratory

Measurements of Retro-                    This research will allow LANL to        as required for the project outlined
Reflections Using Flash                   foresee the applicability of these      above, will be the main objective
Photography                               approaches to LWA calibration           of the LANL portion of this proj-
                                          issues and the applicability of these   ect. This involves LANL because
David Thompson (C-CDE)                    methods to LWA’s projected needs.       the capability to build these finite
LANL is participating in a team pre-                                              element meshes specialized for geo-
paring a U.S. Defense Department          Research Library                        logic applications that seamlessly
Advanced Research Projects Agency                                                 interface with the PyLith physics
(DoD-DARPA) proposal in the area          Herber Van de Sompel (STBPO-RL)         code is unique to LANL.
of sniper detection. As part of the       On behalf of the sponsor, LANL will
proposal preparation process, we          initiate and coordinate the develop-    High Surface Area Nano-
wish to quantify some of the signals      ment of specifications that allow       Structured Cobalt Foams for
we expect to detect. Using flash          distributed repositories to exchange
                                                                                  Catalysis Discovery
photography techniques and a stan-        information about their constituent
dard digital camera and photo flash,      digital objects. These specifications   Bryce Tappan (DE-6)
we will measure retro-reflections         will include approaches for repre-      Development of nanoporous cobalt
(the usual "red-eye" effect) with and     senting digital objects and reposi-     foams containing the properties
without intervening optics such           tory services that facilitate access    needed by Total American Services,
as binoculars. Measurements will          and ingest of these representations.    namely, monolith size, strength
enable calculation of both optical        The specifications will enable a        and surface area. The method
cross sections and return divergence      new generation of cross-repository      was developed by Tappan et al.
angles. The photographed scene            services that leverage the intrinsic    for production of nanostructured
will also include references, such as     value of digital objects beyond the     monolithic metals, including the
white diffusers, for calibration of the   borders of hosting repositories. This   catalyst of interest, metallic cobalt,
reflectivity.                             work is expected to be completed in     and draw on the unique capabilities
                                          a two-year timeframe.                   of LANL in the areas of energetic
LWA Ionospheric Imaging                                                           materials synthesis and handling, as
                                          Finite Element Models                   well as facilities to perform combus-
William Junor (ISR-2)                                                             tion synthesis experimentation. The
                                          Relating Fault Slip Rates,
This work will research the results       Geodetic Deformation,                   self-propagating high temperature
of several different processes includ-                                            synthesis method produces unique
                                          Fault Geometries and Stress
ing Ionospheric Calibration, Wide-                                                nano-structured metals, yet the
field Imaging, and Ionospheric and        Evolution in the Southern               exact structure, surface area and
Meteor Characterization. LANL will        California Fault System                 monolith particle size pertinent
investigate the constraints imposed       Carl Gable (EES-6)                      to this work have not been fully
by the Earth’s ionosphere on (1) the                                              explored. This synthesis method is
calibration of signals detected by the    LANL has developed unique               rapid and produces a nanostruc-
Long Wavelength Array (LWA) and           expertise and tools (LaGriT: Los        tured material with tremendous
(2) the construction of radio astro-      Alamos Grid Toolkit) for building       exposed surface area – ideal for
nomical images using the LWA.             finite element meshes for geological    improved catalysis. The study of
This work is unique to LANL in the        applications. The task of building      transitional metal complexes con-
ability to perform the needed tasks       finite element meshes and the train-    taining high nitrogen complexes,
for this particular research.             ing of MIT student, Jingning Lu,        and the metal monoliths formed

2007 Technology Transfer Awards                                                                                       37
Los Alamos National Laboratory                                                                   Outstanding Innovation

in the combustion synthesis is a        HIV Databases has proven useful         information as it pertains to their
fertile and relatively unexplored       in understanding the mutations,         mission focus.
field. Due to the numerous high         which have led to drug resistant
nitrogen ligand/transition metal        viruses and treatment failure among     GHAVE Sequence Database;
combinations, a wide variety of         individuals in AIDS clinical trials.
                                                                                10 Sequence Analysis/
novel materials can be made and
possibly tailored to study their                                                AIDS Vaccine Discovery
                                        Statistical and Data
ability to form nanoporous metallic                                             Comprehensive Antibody
                                        Management – Adult
structures. We have already discov-                                             Vaccine Immune Monitoring
                                        Analyses
ered the highly promising result                                                Consortium
that the thermal decomposition of       Brian Foley (T-10)
a high-nitrogen iron (III) and cobalt                                           Bette Korber (T-10)
                                        LANL will be devoted to develop-
(III) complex under an inert atmo-                                              The proposed study will enable
                                        ing protocols, methods, and soft-
sphere can lead to the generation of                                            both standardization and detailed
                                        ware programs for the analysis of
porous metal materials containing                                               characterization of neutralizing
                                        AIDS Clinical Trials Group (ACTG)
cells on the micron and nanometer                                               antibody characteristics of sera
                                        data being analyzed by the Harvard
scale. This material was gener-                                                 derived from HIB positive indi-
                                        AIDS Institute's Statistical and Data
ated to provide a material with the                                             viduals during acute infection and
                                        Analysis Center. Areas of exper-
incredibly low density of 0.01 g/cm3                                            vaccine recipients. This will pro-
                                        tise in HIV/AIDS research are the
(for comparison, ultra-low density                                              vide a framework to define subtle
                                        phylogenetic analyses of genetic
aluminum foam has a density of                                                  improvements in vaccine elicited
                                        sequence data, and the evolution of
0.08-0.16 g/cm3), with surface areas                                            neutralizing antibody intensity
                                        drug resistance in HIV-1. Part time
as high as 258 m2/g. The objec-                                                 and cross-reactivity and to com-
                                        is devoted to reading the current
tive of this work here is to provide                                            bine strategies that show promise,
                                        literature on HIV drug resistance
nanostructured Co foam with the                                                 as well to rationally selected and
                                        to stay updated on recent studies.
required structural integrity to                                                design new vaccine reagents based
                                        LANL will also utilize the com-
undergo catalytic testing, which will                                           on antigenic characteristics of pro-
                                        plete data set in the HIV Genetic
also have significantly greater sur-                                            teins of known sequences. A critical
                                        Sequences and Drug Resistances
face areas than existing supported                                              element will be the integration of
                                        Databases at LANL to provide
Co catalysts.                                                                   the results from different studies
                                        "background" sets against which
                                                                                enabling direct comparisons. The
                                        the ACTG trial data sets can be
Statistical and Data Manager                                                    Los Alamos-specific compartment
                                        compared.
                                                                                of our larger database, tailored to
– Pediatric Analyses                                                            meet the needs of this project. Sec-
                                        Techfam Basic Training                  ond, we will provide a web-based,
Brian Foley (T-10)
The HIV Databases at LANL (www.         Timothy White (NN)                      publicly searchable face of the
hiv.lanl.gov) are the global reposi-                                            published data from the consortium
                                        This block of instruction is designed
tory of HIV-1 DNA and protein                                                   to facilitate open exchange of infor-
                                        to prepare personnel in support
sequence data, as well as data on                                               mation. Third, we will assist with
                                        of national emergency response
HIV-1 drug resistance mutations.                                                the analysis and interpretation of
                                        priorities in the fields of nuclear
The analysis of HIV-1 sequence                                                  complex patters of immunological
                                        non-proliferation, detection, and
data from AIDS clinical trials can be                                           reactivity and sequence variation.
                                        consequence management. Sponsor
complex and expertise at the LANL       receives technical instruction and

38                                                                                       2007 Technology Transfer Awards
Outstanding Innovation                                                                   Los Alamos National Laboratory

Thermoacoustic Space                    is present in relatively high concen-   theoretical research on innate and
Power Generator                         trations in the geologic units that     adaptive immunity using a wide
                                        underlie the facility.                  array of approaches and models.
Scott Backhaus (MPA-10)                                                         CETI is formed by scientists from
                                        The purpose of this effort is to
Los Alamos National Laboratory          quantitatively evaluate the isotopic    the University of New Mexico’s
(LANL) will develop a design for a      compositions of field samples from      Department of Biology and Depart-
thermoacoustic engine to be mated       RFETS. Uranium isotopic composi-        ment of Computer Science, Los Ala-
to an electrodynamic linear alter-      tions include four isotopes (masses     mos National Laboratory, and the
nator that is suited for operation      234, 235, 236 and 238). Of these        Santa Fe Institute. CETI’s adminis-
aboard satellites in low-earth orbit.   isotopes, three are naturally present   trative offices are located on UNM’s
The design of the thermoacoustic        (masses 234, 235, 238), and the iso-    main campus within the Biology
engine will take place at LANL          tope with mass 236 is present due to    Department in Castetter Hall.
because LANL has significant            reactions that occur within nuclear     CETI’s main purpose is to foster the
experience in this area which is not    reactors. The RFETS Actinide            career development of junior scien-
present in the private sector.          Migration Evaluation project has,       tists with expertise in evolutionary
                                        therefore, utilized the presence and    and theoretical immunology. It is
Isotopic Uranium Analysis of            amount of 236U as the indicator of      expected that junior scientists sup-
Groundwater                             uranium contamination. Uranium          ported by this project will compete
                                        isotopic measurements are conven-       successfully for NIH grants, which
Michael Murrell (C-NR)                  tionally presented as ratios to 238U,   will allow them to continue their
Uranium processing within the           and for the purpose of evaluating       projects funded initially by CETI.
nuclear and defense industrial          isotopic compositions at RFETS,         This project involves modeling the
complex has been developed to           LANL will utilize ratios of atoms.      immune system and its response
produce a range of different com-                                               to viral and bacterial infections to
positions with differing amounts        Center for Evolutionary and             increase our understanding of basic
of isotopic components. Primarily       Theoretical Immunology                  biological processes underlying
these compositions involve enrich-                                              disease pathogenesis, such as the
ment or depletion in 235U. The          Alan Perelson (T-10)                    rate of viral production in vivo and
three nominal end-member compo-         The Center for Evolutionary and         the death rates of productive
sitions for uranium present at Rocky    Theoretical Immunology (CETI)           infected cells.
Flats Environmental Technology          was established as a Center of
Sites (RFETS) are natural, highly-      Biomedical Research Excellence
enriched, and depleted. In general,     (COBRE) in September 2003, with
highly enriched uranium was care-       funding from the National Center
fully physically controlled, recycled   for Research Resources (NCRR) of
and subject to accounting. Depleted     the National Institutes of Health
uranium was less valuable and sub-      (NIH) and was awarded Category
stantial amounts were discharged to     I Center status from the College of
waste treatment systems, with rela-     Arts and Sciences at the University
tively high levels discharged to the    of New Mexico in April 2006.
Solar Ponds. Natural uranium was
                                        CETI is an interdisciplinary initia-
not directly processed at RFETS, but
                                        tive that conducts empirical and

2007 Technology Transfer Awards                                                                                    39
Los Alamos National Laboratory                                                             Outstanding Innovation


User Facility Agreements         User Facility Agreements permit outside users, including scientists and engi-
                                 neers from industry, universities, and other government agencies to conduct
Executed in                      research using the Laboratory’s unique experimental research equipment
Fiscal Year 2007                 and facilities. The Laboratory has approximately 40 facilities available for
                                 use. Users access the equipment in order to fabricate, calibrate, test, and
                                 evaluate products and processes. The partner directs the activity described
                                 within the agreement for use of the designated facility and pays the full cost
                                 for use of the facility.
                                 Weapons Neutron Research Facility
                                    Stephen Wender (LANSCE-NS), Facility Coordinator
                                    The NSEU Sensitivity of Static Latch and Flash Based Programmable
                                    Logic
                                    Neutron-induced Soft Error and Latch-up Sensitivity in 65 nm and 90 nm
                                    SRAM Memories and Logic Devices
                                    Accelerated Characterization of the Rate of Soft Errors Caused by Cosmic
                                    Neutrons in 0.065 micron SPARC Microprocessor Cells
                                    Single Event Effects on SOI Devices and on DRAM Memories
                                    Accelerated Soft Error Rate Testing of AMD's Single and Multicore
                                    Opteron Microprocessors
                                    Soft Error Characterization of Advanced CMOS Technologies on Asics
                                    and Other Components
                                    New Measurement Techniques for DRAM Single-Event Upsets
                                    Single-Event Effect of Neutron Test on Microelectronics Devices
                                    Measurement of Neutron Induced Event on Latest CMOS Technologies:
                                    SEU, SEL, SEFI and Other Failures: Application to Logic Devices
                                    Measurements of neutron-induced soft error rate in 65 nm-generation
                                    servers, and high performance 90 nm and 65 nm microprocessor chips as
                                    well as 90 nm, 65 nm, and 45 nm test structures
                                    Neutron SEU and SEL Testing of Commercial SRAMs, DRAMs, FPGAs,
                                    ASICs, and Logic and Linear Devices
                                    Power Device Evaluation
                                    Accelerated Characterization of the Rate of Cosmic Neutron Induced Soft
                                    Errors in Multi-core 0.065 micron SPARC Microprocessors
                                    Neutron Soft Error Time-to-fail and Data Corruption Rate Measurements
                                    Study of Advanced SOI Technologies – Investigation of SEU and SET




40                                                                                 2007 Technology Transfer Awards
Outstanding Innovation                                                                Los Alamos National Laboratory


Distinguished Awards              Distinguished                             ultrasonic signal. In particular, Sinha
                                  Patent Award                              found that the positions of the reso-
                                                                            nance peaks for the fluid change as
                                  The Distinguished Patent Award            the composition of the fluid and the
                                  honors inventors whose patented           flow rate of the fluid change.
                                  invention exhibits outstanding inno-      He also found that the spacings
                                  vation. The award is selected by the      between successive resonance peaks
                                  Laboratory Patent Advisory Council        change in response to changes in
                                  and recognizes a premier patent           composition but not to changes in
                                  exemplifying significant technical        flow rate. Thus, by measuring the
                                  advance, adaptability to public use,      resonance positions and the spac-
                                  and noteworthy value to the mission       ings between them, the flow rate and
                                  of Los Alamos National Laboratory.        composition of the flowing fluid may
                                  The patent and the inventors recog-       be determined.
                                  nized for this award reflect the Labo-
                                  ratory’s stalwart tradition of superior   Distinguished
                                  technical innovation and creativity.      Copyright Award
                                  2007 Award Winner                         The Distinguished Copyright Award
                                  The 2007 Distinguished Patent             honors the authors of disclosed
                                  Award goes to the patent titled           copyrighted materials that are
                                  “Noninvasive Characterization of          considered extraordinary creations.
                                  a Flowing Multiphase Fluid Using          Nominated copyrights for this award
                                  Ultrasonic Interferometry,” submit-       demonstrate a breadth of commercial
                                  ted by Dipen N. Sinha of MPA-11           applications, potential to create eco-
                                  (Sensors and Electrochemical              nomic value, and the highest level
                                  Devices). This patent, along with         of technical excellence. In addition,
                                  several other pieces of intellectual      these works represent vital contribu-
                                  property, has been licensed to Safety     tions to the Laboratory’s mission
                                  Scan and Chevron and was previ-           and provide reciprocal benefit to the
                                  ously licensed to Edge Technologies       Laboratory programs under which
                                  for use in water testing and oil and      they were developed.
                                  gas applications.                         Recipients of this award are true
                                  The patented invention is an appara-      innovators in their field and advance
                                  tus and method that uses ultrasound       the Laboratory’s reputation in scien-
                                  to noninvasively monitor the flow         tific excellence through their copy-
                                  rate and/or the composition of a          righted works and software.
                                  flowing fluid. The basis of the inven-
                                  tion is the finding that changes in the   2007 Award Winner
                                  composition and flow rate of a flow-      The 2007 Distinguished Copyright
                                  ing fluid can be determined by excit-     Award goes to the copyright
                                  ing the fluid with a swept frequency      “EpiCast™” by Tim Germann of the

2007 Technology Transfer Awards                                                                                 41
Los Alamos National Laboratory                                                                  Outstanding Innovation

Theoretical Chemistry and Molecu-       Distinguished Licensing                oil and gas exploration. Along with
lar Physics Group (T-12). EpiCast™      Award                                  this breakthrough technology, Zhao
(epidemiological forecasting) was                                              has demonstrated outstanding suc-
designed to help epidemiologists        The Distinguished Licensing Award      cess in transferring this technology
understand the spread and impact        recognizes innovators who proac-       with his participation in technical
of an avian influenza (H5N1)            tively engage in commercialization     discussions in understanding the
pandemic. The system models the         activities at Los Alamos National      value of the technology and how it
pandemic at the individual human        Laboratory and who have had a          could be integrated into the exist-
level using the most current data on    positive impact on the Laboratory’s    ing processes of the company. He
the natural and deliberate spread of    Licensing Program. These indi-         has demonstrated the strengths and
pathogens in human populations.         viduals, by example, demonstrate       limitations of the technology and
The computer simulation models a        outstanding success in transferring    how to best facilitate the technol-
synthetic population that matches       Laboratory-developed technologies      ogy’s entrance into the commercial
available census demographics and       to the public and private sectors.     world. Zhao provided valuable
worker mobility data by randomly        In addition, recipients’ commer-       written descriptions to the com-
assigning the simulated individu-       cialization track record has served    pany that allowed it to effectively
als to households, workplaces, and      to enhance the reputations of Los      apply the technology to create the
schools and using travel data to        Alamos National Security LLC and       world’s toughest synthetic drill bits.
model long-distance trips, realisti-    the Laboratory.                        US Synthetic’s super hard drill bits,
cally capturing the spread of the       The recipients of this distinguished   made possible by Zhao’s innovation
pandemic virus by airplane and          award are champions for the            and participation in the transfer of
other passenger travel. Addition-       Laboratory’s licensing program         this technology, are being used today
ally, the model of disease transmis-    and are recognized for their role in   in oil exploration all over the globe.
sion involves probabilities that any    confirming the benefits of proac-      Without enthusiastic and dedicated
two people in a population will         tive technology commercialization      scientists such as Zhao the world
meet on any given day in any one        activities.                            would still be using inferior drill bits
of a number of settings, such as                                               for oil exploration.
home or workplace.                      2007 Award Winner
EpiCast™ can be used to assist                                                 Programmatic Impact Award
                                        The 2007 recipient of the Distin-
corporate and government policy-        guished Licensing Award is Yush-       The Programmatic Impact Award
makers with planning strategies at      eng Zhao of LANSCE-LC (Lujan           honors individuals or groups who
all levels (community, work, school,    Neutron Scattering Center). Zhao       have made advancements to the
etc.) to help mitigate the effects of   is the inventor of a novel nano-       programmatic mission of Los Alamos
serious disease outbreaks while         structured composite that consists     National Laboratory through their
maintaining critical business and       of diamond particles embedded in       interactions with industry partners.
government operations. It has the       a matrix of nanocrystalline silicon    Nominees have interacted with
additional advantages of being          carbide. The superhard, ultratough     industry partners through a technol-
flexible with regard to data type       nanocomposites have been exclu-        ogy transfer mechanism (Cooperative
and input methods and adaptable         sively licensed to US Synthetic,       Research and Development Agree-
to other virulent and seemingly         which leads the industry in the        ment, Work for Others, Licensing,
random processes.                       development and production of          User Facility Agreement, or Memo-
                                        polycrystalline diamond cutters for    randum of Understanding) to add

42                                                                                      2007 Technology Transfer Awards
Outstanding Innovation                                                                     Los Alamos National Laboratory

value to the technology field in         suite of four unique GFP variants, is   2007 Technology Transfer
which they work for programmatic         the most advanced protein-folding       Regional Impact Award
and commercial uses.                     reporter tool currently available.
The recipients of this award dem-        Split GFP solves problems associated    This award honors individuals,
onstrate stellar technical prowess as    with tagging target proteins using      organizations, or programs that
well as the innovation and creativity    standard, somewhat bulky GFP by         have made a significant contribu-
needed to demonstrate excellence in      providing a GFP µTag—a small, 15        tion to the northern New Mexico
both programmatic and commercial         amino acid fragment of the GFP. Split   economy. Recipients must have a tie
applications.                            GFP, the most advanced tool in the      to LANL technology, personnel, or
                                         toolbox, can be used to localize pro-   expertise. (Per Appendix N of the
2007 Award Winners                       teins and determine protein-protein     LANS, LLC M&O Prime contract,
                                         interactions.                           the Laboratory actively encourages
Geoffrey S. Waldo and Stephanie                                                  the development of new businesses
                                         The GFP technology supports the
Cabantous, of Biosience, Advanced                                                based on Laboratory technology
                                         Laboratory’s Structural Genom-
Measurement Sciences Group (B-9),                                                or expertise.)
                                         ics program. Structural genomics
are the recipients of the 2007 Pro-
                                         is an effective short-term means of     Nominees for this award must
grammatic Impact Award for their
                                         obtaining structural information on     demonstrate northern New Mexico
work on the Green Fluorescent
                                         proteins of high medical, biological,   economic impact through the cre-
Protein (GFP) technology. One of
                                         or biophysical interest, including      ation or growth of LANL-affiliated
their major accomplishments in this
                                         proteins from pathogens or those        venture(s), creation of new jobs or
field is development of the GFP
                                         involved in human disease. As part      new products, or implementation
Toolbox designed to help scientists
                                         of a team that pioneered the field of   of a unique resource for entrepre-
understand and solve the mysteries
                                         structural genomics and assisted in     neurs. In addition, the individual,
of protein dysfunction—the cause of
                                         founding the International Structural   organization or program must
many diseases—including misfold-
                                         Genomics organization, Waldo’s and      reflect the spirit of entrepreneurship
ing, aggregation, and abnormal
                                         Cabantous’s work focuses on devel-      through personal risk taking, strong
movement.
                                         opment of technologies that allow       personal commitment, ingenuity,
The GFP Toolbox includes four            rapid protein structure determina-      and act as a role model for regional
GFP-based tools: Folding Reporter,       tion and on production of purified      innovation.
SuperFolder, Insertion, and Split        proteins and determination of their
GFP. This suite enables researchers      three-dimensional structures as part    2007 Award Winners
to perform experiments impos-            of the National Institutes of Health
sible to do with conventional GFP.                                               The recipients of the 2007 Regional
                                         Protein Structure Initiative for the
Folding Reporter reports on the                                                  Impact Award are Laboratory
                                         Laboratory.
success of a target protein’s folding                                            inventors Steven Graves, Gregory
                                         GFP has been licensed to Merck &        Goddard, John Martin, Robert
and solubility. It is used by over 100
                                         Co. Inc. and Johnson & Johnson for      Habbersett, and Mark Naivar of the
labs and has been cited in over 300
                                         commercial uses and many non-           Bioscience Division, and Gregory
publications in a wide range of fields
                                         commercial licensees have used the      Kaduchak and Michael Ward of
including structural genomics and
                                         GFP technology. The participation       Acoustic Cytometry Systems Inc. of
drug discovery. SuperFolder reports
                                         by industry allows our inventors        Los Alamos.
on a target protein’s expression and
                                         to improve the technology for both
is a more robustly folded Version of                                             The Los Alamos-based company is
                                         industrial uses and NIH mission-
Folding Reporter. Insertion GFP, a                                               a biotech startup commercializing
                                         critical uses.

2007 Technology Transfer Awards                                                                                      43
Los Alamos National Laboratory                                                            Outstanding Innovation

a revolutionary method developed        neurial Leave of Absence from the
at the Laboratory for concentrating     Laboratory to help ACS commercial-
and aligning particles in a capil-      ize its invention. The company’s
lary. The company’s first product       proprietary technology provides the
line will be a platform of novel        unprecedented ability to concentrate
cell analysis instruments initially     and align particles in a flow system.
targeted at life science research and   With acoustic focusing, density-
ultimately deployed for clinical        based separations are possible in
diagnostics. The company’s com-         automated flow systems rather than
mercial goal is to create proprietary   a centrifuge. Acoustic focusing also
instruments and applications with       enables a wide range of new cell
unique capabilities starting with       analysis techniques.
breakthrough solutions in cellular      In 2007, ACS received an award
analysis and sample preparation.        from the LANS Venture Acceleration
The second product line will be         Fund that supported development
used to wash and concentrate cells      of the company’s first integrated
and particles. Washing and concen-      working prototype.
tration are standard manual steps in
                                        Founder, president, and CEO John
clinical and research sample prepa-
                                        Elling, says, “The technical success of
ration. Acoustic focusing provides
                                        the project has enabled ACS to grow
the unique capability to automate
                                        to eight employees in less than a year
this process—saving time and labor
                                        and to secure critical seed funding
and improving quality.
                                        from private seed investors.”
One of the inventors, Greg
Kaduchak, is currently on Entrepre-




44                                                                                2007 Technology Transfer Awards
Outstanding Innovation                                                            Los Alamos National Laboratory


IDEAS                                     After submission, invention disclo-
                                          sures are routed electronically for
The Technology Transfer (TT)              approvals, archiving, and entry into
Division's IDEAS (Information             TT Division's Opportunity Module.
Disclosure Electronic Application         Launched in November 2005 as a
System) automates the first and           part of TT Division's commitment
most critical step in the technology      to streamlining, IDEAS has had an
transfer process—receiving inven-         immediate impact on the disclo-
tion disclosures from the Laborato-       sure process by enabling enhanced
ry's research staff. This collaboration   collaboration and reducing the
tool allows multiple users to author      total time required to produce high
and edit disclosure drafts via a Web      quality disclosures and expedite the
browser, helping inventors create,        approval process.. The total number
modify, review, and submit inven-         of invention disclosures submitted
tion disclosures electronically.          annually has continued to increase
The disclosure process provides           over the past three years since the
Laboratory Legal Counsel with the         launch of IDEAS.
information necessary to file a pat-      Coming soon, IDEAS 2.0, a more
ent application and the TT Division       robust system, will expedite the dis-
with the vital information needed         closure process even more and will
for successful, commercial, noncom-       enable the electronic submission of
mercial, and academic licensing           copyright disclosures as well.
and transfer of an invention to the       To process a disclosure visit:
public/private sector.                    www.lanl.gov/my_idea




2007 Technology Transfer Awards                                                                             45
Los Alamos National Laboratory                                                          Outstanding Innovation


Technology Transfer              Since 1997, the Technology Transfer    based on Los Alamos National
                                 (TT) Division has offered a variety    Laboratory (LANL) technol-
Division                         of programs and services to facili-    ogy or expertise. Each year, the
Regional Economic                tate spinoffs from the Laboratory.     LANS Venture Acceleration Fund
Development Programs             These programs have also been          provides investments of up to
                                 instrumental in strengthening the      $100,000 to facilitate 3–5 projects
                                 northern New Mexico startup com-       with regional entrepreneurs,
                                 munity as a whole. Specific pro-       companies, investors, or strategic
                                 grams and initiatives include:         partners. Proposals submitted to
                                                                        the LANS Venture Acceleration
                                 Internal Technology                    Fund must describe projects that
                                 Maturation Fund                        develop and refine novel solu-
                                                                        tions for which strong market
                                 In 2002, an internal Technology        demand has been demonstrated
                                 Maturation Fund was developed to       and through which regional
                                 provide small amounts of funding       economic development can be
                                 for highly focused projects within     achieved. Projects must be driven
                                 the Laboratory to move early-stage     by clear, distinct, and achievable
                                 technologies along the road to com-    commercial milestones within a
                                 mercialization. Unlike many types      specified timeframe. Evaluation
                                 of funding within the Laboratory,      criteria include regional impact,
                                 these awards are not for a specific    team composition, technical fea-
                                 time period but rather to achieve      sibility, market opportunity, and
                                 a specific milestone in a defined      the availability of matching funds
                                 development path leading to com-       or in-kind contributions. To date,
                                 mercialization. The funds are meant    six LANL licensees have received
                                 to remove specific hurdles to devel-   VAF funds to advance company
                                 opment of early stage technologies     milestones.
                                 in the Laboratory. To date, the Fund
                                 has shown an impressive return         Entrepreneurial Leave of
                                 on its investment of $2.4 million in   Absence (ELOA) Program
                                 45 projects, including helping to
                                 launch five startup companies that     In 1998, the Laboratory adopted an
                                 have cumulatively raised over $7       ELOA policy for the first time. The
                                 million in private investment.         ELOA policy allows employees to
                                                                        take an unpaid leave, for a limited
                                 LANS Venture                           period, to pursue entrepreneurial
                                 Acceleration Fund                      activities utilizing Laboratory tech-
                                                                        nology or intellectual property. The
                                 The LANS Venture Acceleration          policy also allows the employee
                                 Fund (VAF) supports projects           to retain access to certain Labora-
                                 that facilitate the creation and       tory benefits. The purpose of the
                                 growth of regional businesses

46                                                                              2007 Technology Transfer Awards
Outstanding Innovation                                                           Los Alamos National Laboratory

program is to reduce risk for Labo-    to foster entrepreneurial efforts
ratory employees and to facilitate     within the Laboratory and to pioneer
the attempt to start new businesses.   a streamlined process for spinning
Since its inception, 37 employees      out certain strategic technologies.
have taken entrepreneurial leave       The Visiting Entrepreneurs work
of absence.                            closely with TT and technical staff to
                                       help them identify product concept
Market and Business                    roadblocks, product development
Planning Assistance                    technical milestones and funding
                                       requirements, viable commercializa-
TT works with our technical staff      tion paths
to assess and package technologies     and, as appropriate, key staff that
that could form the basis of a new     may be needed for a new spin-out
company. In addition, through TT’s     opportunity.
MBA Internship Program, initiated
in 1996, MBA candidates evaluate       Northern New Mexico
Los Alamos inventions for commer-      CONNECT
cialization potential, working with
the inventors to develop technology    Launched in December 2007,
transfer strategies. In addition, TT   sponsored by LANS and LANL,
works with regional entrepreneurs      in partnership with the Regional
to help them access the knowledge,     Development Corporation, NNM
skills, funds, and business connec-    CONNECT is growing an ecosys-
tions necessary for success. Since     tem for enterprise development and
1997, we have assisted over 600        networking for long-term economic
clients; 87 of these are startups      growth in the region. It is designed to
                                       help build an innovation community
Visiting Entrepreneurs                 in northern New Mexico through the
                                       investment of stakeholders.
The Visiting Entrepreneurs program
seeks to build on successful experi-
ence while tailoring new approaches




2007 Technology Transfer Awards                                                                            47
Los Alamos National Laboratory                                                              Outstanding Innovation


Contact List                     Outstanding innovation is the             Laboratory Counsel
                                 cornerstone that enables patents,         Laboratory Counsel
                                 copyrights, licenses, and the ensuing     Steven Porter, 667-3970
                                 entrepreneurial ventures to occur.        Intellectual Property Office
                                 The teams cited below are key to the      Group Leader
                                 Laboratory’s activities required to       Bruce Cottrell, 667-9168
                                 protect our intellectual property and
                                                                           Patent Agent
                                 encourage the transfer of technology
                                                                           Sam Borkowsky, 665-3111
                                 to the private sector. for questions or
                                 assistance please contact any of these    General Law
                                 individuals.                              David Salazar, 665-6697
                                 Technology Transfer Division              Patent Attorney
                                 Division Leader                           Juliet Jones, 606-2235
                                 John Mott, 665-0883                       Technology Transfer Division
                                 Chief of Staff                            www.lanl.gov/partnerships/
                                 David Holmes, 665-6747                    Laboratory Counsel
                                 Contracts Management                      www.lanl.gov/orgs/lc/
                                 Contract Compliance Manager
                                 Susan Brockway, 665-7677
                                 Technology Management Office
                                 Program Manager
                                 John Mott, 665-0883
                                 Team Leaders
                                 Laura Barber, 667-9266
                                 Kathleen McDonald, 667-5844
                                 David Pesiri, 665-7279
                                 John Russell, 665-9597
                                 Intellectual Property Management
                                 Program Manager
                                 Ken Freese, 667-1928
                                 Intellectual Property Specialist
                                 Christine Ramos, 665-6846
                                 Patent Analyst
                                 Marcus Lucero, 665-6569
                                 Competitive Intelligence Analyst
                                 Donna Berg, 667-8129




48                                                                                 2007 Technology Transfer Awards

				
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