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EPICENTRE BIOTECHNOLOGIES
726 Post Road, MADISON WI 53713
Emergency Tel: 608-258-3080 or 800-284-8474 7:30-4:30 Central
MATERIAL SAFETY DATA SHEET
Prepared 8/2010
Section I: Product Information
Product: 5M Lithium chloride, 5 M LiCl as a component of MOE51010, MOE51024, MOP51010 and MOP51024. The
information below is for the solid form.
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Section II: Composition/Information on Ingredients
Substance Name CAS# Sara 313
Lithium chloride (LiCl) 7447-41-8 No
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Section III: Hazards Identification
May cause harm to an unborn child. May cause harm to breastfed babies. Possible risk of impaired fertility. Harmful if
swallowed.
HMIS Rating Health 2* Flammability: 0 Reactivity: 1
NFPA Rating Health 2 Flammability: 0 Reactivity: 1
*Additional chronic hazards present.
For additional information on toxicity refer to section 11.
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Section IV: First Aid Measures
Oral exposure: If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
Inhalation exposure: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult,
give oxygen.
Dermal exposure: In case of skin contact, immediately flush with copious amounts of water for at least 15 minutes.
Remove contaminated clothing and shoes. Call a physician.
Eye exposure: In case of eye contact, flush with copious amounts of water for at least 15 minutes. Assure adequate
flushing by separating the eyelids with fingers. Call a physician.
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Section V: Fire Fighting Measures
Autoignition point: N/A
Extinguishing Media: water spray, carbon dioxide, dry chemical, an appropriate foam
Fire Fighting Protective Equipment: Wear full protective equipment, including a self-contained breathing apparatus to
prevent contact with eyes and skin.
Specific hazards: Emits toxic fumes under fire conditions.
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Section VI: Accidental Release Measures
Personal Precautions: Evacuate area. Wear self contained breathing apparatus and protective clothing to avoid contact
with skin and eyes.
Clean up method: Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill
site after material removal is complete.
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Section VII: Handling and Storage
Handling: User exposure: Avoid inhalation. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
Storage: Keep tightly closed. Store in a cool dry place.
Special Requirements: Hygroscopic
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Section VIII: Exposure Controls/PPE
Engineering Controls: Use in a chemical fume hood. Safety shower and eye bath
Hand protection: Chemically resistant gloves.
Eye protection: Chemical safety goggles
Respiratory Protection: government approved respirator.
General Hygiene Measures: Wash contaminated clothing before reuse. Wash thoroughly after handling.
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8/2010
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Section IX: Physical/Chemical Properties
White solid dissolved in water
Molecular Weight: 42.39
pH: 6
Boiling Point: 1360 C ˚
Explosion Limits: N/A
Partition coefficient: log KOW -2.7
Vapor Pressure (mm Hg): N/A
Vapor Density (air = 1): N/A
Solubility in water: N/A
Specific Gravity: 2.07 g/cm3
Bulk density: 530 kg/l
Melting Pt.: 605 C˚
Evaporation Rate: N/A.
Flash Point ˚C: N/A
Flash Point ˚F: N/A
Flammability: N/A
Exposion limits: N/A
Autoignition Temp: N/A
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Section X: Stability and Reactivity
Stability: stable
Conditions to avoid: Protect from moisture.
Materials to avoid: Strong acids, strong oxidants, BF3
Hazardous thermal decomposition products: HCl, Lithium oxides
Hazardous polymerization: Will not occur.
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Section XI: Toxicological Information
Route of exposure: Causes severe skin irritation
Skin absorption: May be harmful if absorbed through skin.
Eye Contact: Causes eye irritation
Inhalation: May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
Target Organ(s) or System(s): Central Nervous System. Kidneys. Cardiovascular system. Thyroid.
Signs and Symptoms of Exposure
Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache,
nausea, and vomiting. Cyanosis and t-wave inversion have occurred in the breast-fed infants of women receiving lithium
carbonate therapy. Large does of lithium ion have caused dizziness and prostration and can cause kidney damage if sodium
intake is limited. Dehydration, weight loss, dermatological effects, and thyroid disturbances have been reported. Central
nervous system effects that include slurred speech, blurred vision, sensory loss, ataxia, and convulsions may occur. Diarrhea,
vomiting, and neuromuscular effects such as tremor, and hyperactive reflexes may occur as a result of repeated exposure to
lithium ion. To the best of our knowledge, the chemical, physical and toxicological properties have not been thoroughly
investigated.
RTECS #: OJ5950000
Toxicity Data:
Oral- human 200 mg/kg (LDLO)
Remarks: Behavioral somnolence (general depressed activity)
Behavioral: muscle weakness. Muscle contraction or spasticity
Oral Rat: 526 mg/kg (LD50)
Intraperitoneal – rat 514 mg/kg (LD50)
Subcutaneous- rat 499 µg/kg (LD50)
Intracerebral: rat: 4800 µg/kg (LD50)
Remarks: Behavioral: altered sleep time (including change in righting reflex)
Behavioral somnolence (general depressed activity)
Nutricianal and gross metabolic: changes in body temperature decrease.
Intratracheal- rat 205 mg/kg (LD50)
Oral – mouse: 1,165 mg/kg (LD50)
Intraperitoneal – mouse 600 mg/kg (LD50)
Subcutaneous- mouse 738 mg/kg (LD50)
Intravenous –mouse: 363 mg/kg (LD50)
Remarks: Brain and coverings: recordings from specific areas of CNS.
Behavioral: somnolence (general depressed activity)
Intraperitoneal- cat: 494 mg/kg (LD50)
Oral rabbit: 800 mg/kg (LD50)
Intraperitoneal- guinea pig: 624 mg/kg (LD50)
Oral – Quail 422 mg/kg (LD50)
Oral- bird (wild) 422 mg/kg (LD50)
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Irritation Data:
Skin- rabbit: 500 mg 24 hours: severe irritation effect.
Eyes- rabbit: 100 mg 24 hours: moderate irritation effect.
Chronic exposure carcinogen
Mouse- intraperitoneal: 882 mg/kg 7D I: Result: Tumorigenic; neoplastic by RTECS criteria. Blood lymphomas
including Hodgkin’s disease.
Chronic exposure tetratogen
Species Dose Route of Application Exposure time
Rat 809 mg/kg intraperitoneal 9-16 days preg
May cause congenital malformation in the fetus.
Result: specific developmental abnormalities: eye, ear
Specific developmental abnormalities: craniofacial (including nose and tongue)
Effects on embryo or fetus: other effects to embryo
Mouse 66 gm/kg oral 1-2 day preg/21Day post
Result: specific developmental abnormalities. Central nervous system.
Effects on newborn: biochemical and metabolic.
Effects of newborn: physical.
Mouse 1240 gm/kg subcutaneous 12-13 day preg
Result: specific developmental abnormalities. Craniofacial (including nose and tongue).
Chronic exposure mutagen
Species Dose Cell type Mutation Test
Human 50 mg/l lymphocyte DNA inhibition
Human 70 mmol/l HeLa cell DNA inhibition
Human 50 mg/l lymphocyte cytogenic analysis
Mouse 212 µg/kg oral, 3D cytogenic analysis
Mouse 21 mg/kg oral 3D Sister chromatid exchange
Chronic exposure- reproductive hazard
Species Dose Route of Application Exposure Time
May cause reproductive disorders
Rat 41360 mg/kg Intraperitoneal (1D Male)
Effects on fertility: mating performance
Rat 979 mg/kg Intraperitoneal (7-16 D preg)
Effects on fertility: post implantation mortality
Rat 1 gm/kg intraperitoneal (7-11 day preg)
Effects on fertility: abortion Effects on embryo or fetus: fetal death
Rat 1250 mg/kg intraperitoneal (7-11 day preg)
Effects on fertility: litter size
Rat 28 mg/kg subcutaneous 14 days male
Paternal effects: other effects on male. Endocrine: change in LH. Endocrine: androgenic.
Rat 42 mg/kg subcutaneous 21 day male
Paternal effects: spermatogenesis (including genetic material, sperm morphology, motility, and count)
Mouse 475 mg/kg oral 7 day male/7d pre- 21 day post
Effects on newborn: growth statistics, biochemical and metabolic, physical.
Mouse 320 mg/kg intraperitoneal 6-7 days preg
Effects on newborn: other neonatal measures or effects.
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Section XII: Ecological Information
Acute Ecotoxicity Tests
Test Type: EC50 Daphnia Species: Daphnia magna Value: 7.2 mg/l
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Section XIII: Disposal Considerations
Use appropriate method for disposal according to federal, state, and local environmental regulations.
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Section XIV: Transport Information
DOT: Proper Shipping Name: none This substance is considered non-hazardous for transport
IATA: Non-hazardous for air transport.
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Section XV: Regulatory Information
EU Additional Classification
Symbol of danger: Xn Indication of danger: Harmful
Risk statements: Harmful if swallowed. Irritating to eyes, respiratory system and skin.
Safety statements: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
US classification and Label Text: Indication of danger: toxic
Risk statements: may cause harm to unborn child. May cause harm to breastfed babies. Possible risk of impaired
fertility. Harmful if swallowed. Irritating to eyes and respiratory system.
Safety statements: Avoid exposure- obtain special instructions before use. In case of accident or if you feel unwell,
seek medical advice immediately. Wear suitable protective clothing, gloves, and eye protection.
US statements: Causes severe irritation to skin. Target organ(s): central nervous system, kidneys.
United States Regulatory Information
SARA listed: No
Canada Regulatory Information:
WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR and the
MSDS contains all the information required by the CPR: DSL:Yes NDSL: No
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Section XVI: Other Information
For R&D use only. Not for drug, household or other uses.
The information herein is based on data and tests believed to be reliable; however, EPICENTRE makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. This
document is offered solely as a guide for the customer's consideration, investigation and verification. These
suggestions do not replace state, municipal and/or insurance requirements. Any use of this information must be
determined by the user to be in accordance with applicable Federal, state and local regulations.
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