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									    The Long Road to a New Medicine




                      John H. (Wick) Johnson, Ph.D.
              Pfizer Global Research & Development
                                Ann Arbor, Michigan



1                                                      GL-1543a
                                                      EDIT-long-road
     The Long Road to a New Medicine

                                  Registration

       Full
    Development




        Exploratory Development




                                  Discovery


2                                                 GL-1543a
                                                 EDIT-long-road
     The Long Road to a New Medicine

                                            Registration

       Full
    Development




                                                               Candidate


        Exploratory Development


                                                                Early
                                                               Safety
                                                               Studies
                   Project Team      Synthesis     Screening
                    and Plans     of Compounds

                                                 Discovery

                                                                         GL-1543a
3                                                                    GL-1543a11/00
                                                                          Rev.
                                                                    EDIT-long-road
     The Long Road to a New Medicine

                                                Registration

       Full
    Development


                                          Large Amounts of
                                         Candidate Medicine
                                            Synthesized

                                                                                     Extensive
                                                                                       Safety
                                                                                      Studies
              Studies in Healthy                                                                 Candidate
              Volunteers Phase I                                      Formulations
                                                                       Developed
        Exploratory Development


                                                                                                   Early
                                                                                                  Safety
                                                                                                  Studies
                       Project Team
                                         Synthesis            Screening
                        and Plans
                                      of Compounds
                                                     Discovery


4                                                                                                       GL-1543a
                                                                                                       EDIT-long-road
        The Long Road to a New Medicine

                                                  Clinical Data                  Registration
                                                    Analysis



           Full
        Development
         Studies in 100-300
         Patients (Phase II)                                               Candidate Medicine Tested in
                                                                            3-10,000 Patients (Phase III)


                                                                      Large Amounts of
                                                                     Candidate Medicine
                                                                        Synthesized

                                                                                                                      Extensive
                                                                                                                        Safety
                                                                                                                       Studies
                          Studies in Healthy                                                                                      Candidate
                          Volunteers Phase I                                                           Formulations
                                                                                                        Developed
          Exploratory Development


                                                                                                                                    Early
                                                                                                                                    Safety
                                                                                                                                   Studies
                                   Project Team                      Synthesis             Screening
                                    and Plans                     of Compounds
                                                                                     Discovery


    5                                                                                                                                    GL-1543a
                                                                                                                                           GL-1543a
                                                                                                                                        EDIT-long-road
5                                                                                                                                            Rev. 11/00

								
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