PATIENT INDEX TEST REFERENCE FLOW AND
SELECTION STANDARD TIMING FLOW AND TIMING
Study 1 Low Low Low Low
Study 2 Low Low Low Low
QUADAS-2 Domain
Study 3 High High Low Low
REFERENCE STANDARD
Study 4 High High Low Low
Study 5 High Unclear Low Unclear
Study 6 High Unclear Low Low INDEX TEST
Study 7 High Unclear Unclear Low
Study 8 High Unclear Low Low
Study 9 High Unclear Low Low PATIENT SELECTION
Study 10 Low Unclear Low High
Study 11 Unclear Unclear Low High
Low 7 2 11 9
High 7 2 0 2
Unclear 0 7 0 0
Low High Unclear
LOW AND TIMING
RENCE STANDARD
INDEX TEST
ATIENT SELECTION
0% 20% 40% 60% 80% 100% 0% 20% 40% 60% 80%
Proportion of studies with low, high or unclear Proportion of studies with low, high, or unclear
RISK of BIAS CONCERNS regarding APPLICABILITY
80% 100%
low, high, or unclear
g APPLICABILITY
PATIENT INDEX TEST REFERENCE STANDARD
SELECTION
Study 1 High Low Low
Study 2 High Low Low
Study 3 High Low Low
Study 4 High Low Low
Study 5 High Low Low
Study 6 High Unclear Low
Study 7 High Low Low
Study 8 High Unclear Low
Study 9 High Low Low
Study 10 Low Low Low
Study 11 Low Low Low
Low 2 0 11
High 9 9 0
Unclear 0 2 0