EMS CAT AL OG NO: 20400
EMS PR ODUCT : Pr opylene Oxide
DAT E: 08/ 17/ 2001
PAGE NUMB ER : ONE of 7
MAT ER I AL S AFET Y DAT A S HEET
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P.O. B OX 251
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(215) 646-1566 CHEMT R EC: (800) 424-9300
FOR PR ODUCT AND S AL ES I NFOR MAT I ON
C T T
ONT AC ELEC RON MI CROSC I ES E
OPY SC ENC OFFI C ABOVE.
PR ODUCT I DENT I FI CAT I ON
PRODUC NAME: Propylene Oxide
COMMON NAMES/SYNONYMS: PO, 1-2 Epoxyporpane, Propene Oxide, Methyl Ethylene
Oxide, Methoxirane, Propylene Epoxide, Epoxypropane
C NUMBER: 75-56-9
PRODUC USE: Used primarily as an intermediate in the synthesis of other
chemicals and polymers; as a fumigant for dried fruits and food stuffs; as a mixture with
CO2; as a stabilizer for methylene chloride; treating wood for termite resistance; acid
scavenger; pH control agent; as a treatment chemical for removing residual from crude
HAZARD RAT I NG (NFPA 49): HAZARD RAT I NG SCALE:
HEALT H: 2 0= MI NI MAL 3= SERI OUS
FI RE: 4 1= SLI G HT 4= SEVERE
REAC I VI T Y: 2 2= MODERAT E
SPEC AL: NONE
HAZ AR DOUS I NGR EDI ENT S
COMPONENT : HT
WEI G BY % : AS
Propylene Oxide 100% 75-56-9
OSHA AC I ON LEVEL (8HR T WA): Not applicable.
OSHA PEL 8 HR T WA: 20ppm (50 mg/m3)
AC I H T LV:
T LV-T WA: 20ppm (48 mg/m3)
I DLH: 2000ppm
LD50: 1140 mg/kg, Rat-Oral
LC (4 HOUR): 4000ppm Rat-I nh
PHYS I CAL / CHEMI CAL CHAR ACT ER I S T I CS
BOI LI NG POI NT : 94oF / 34.2oC
FREEZI NG : -169oF / -111.7oC
SPEC FI C G RAVI T Y: 0.8330 at 20/20oC
VAPOR PRESSURE: 455oC mm Hg
VAPOR DENSI T Y(Air= 1): 2.0
WAT ER SOLUBI LI T Y: 39.5% @ 20oC
MOLEC ULAR WEI G : HT 58.08 grams/mole
PERC ENT VOLAT I LES BY VOL. 100%
EVAPORAT I ON RAT E: 33.70 Butyl Acetate= 1
pH: Not applicable.
ODOR T HRESHOLD: 200ppm
APPEARANC AND ODOR: C lear colorless liquid with a sweet ether like odor. Odor
threshold: 200 ppm
Catalog # 20400 2
FI R E AND EXPL OS I ON I NFOR MAT I ON
FLASH POI NT : T ag Open C up: < -35oF / < -37.2oC
T ag Closed Cup: -35oF / -37.2oC
FLAMMABLE LI MI T S I N AI R, % : LOWER: 1.7%
NFPA HAZARD SYMBOL CODES: Flammability: 4
AUT O I G T I ON T EMP.:
NI 869oF (465oC )
I G T I ON T EMP.:
NI 840oF (449oC )
EXT I NG SHI NG MEDI A: Dry chemical; Alcohol resistant foam; Carbon dioxide.
Water spray/fog can be used for cooling.
HAZARDOUS DEC T
OMPOSI T I ON BY PRODUC S: I ncomplete combustion will generate
highly poisonous carbon monoxide and perhaps other toxic vapors.
SPEC AL FI RE FI G I NG PROC EDURES: Wear NI OSH approved self contained
breathing apparatus (SC BA) with a full facepiece operated in the pressure-demand or
positive pressure mode. Fight fires from a safe distance/protected location. Heat may
build pressure in a rupture closed containers. I f recommended foam is not available,
cut off the supply of fuel to the fire, maintain water spray to prevent spreading and
allow fire to burn out.
UNUSUAL FI RE AND EXPLOSI ON HAZARDS: Propylene Oxide releases flammable
vapors below normal ambient temperatures. When mixed with air and exposed to a
source of ignition. I t can burn in the open or explode if confined. Flammable vapors
may be heavier than air, and may travel long distances along the ground before igniting
and flashing back to the vapor source. Vapor air mixtures are explosive above flash
R EACT I VI T Y DAT A
ST ABI LI T Y: Stable
HAZARDOUS POLYMERI ZAT I ON: May polymerize on exposure to excessive heat,
peroxides, acids, alkalis, or amines.
I NCOMPAT I BI LI T I ES: Strong acids, bases, peroxides, clay-based adsorbent materials
anhydrous metal chlorides, copper and its alloys, brass, bronze and other acetylide
Catalog # 20400 3
CONDI T I ONS T O AVOI D: C ontact with incompatible chemicals. Prevent exposure to any
and all sources of ignition such as heat, sparks, open flame, etc. Avoid oxidizing
HEAL T H HAZ AR D DAT A
PRI MARY ROUT ES OF EXPOSURE: I nhalation, skin or eye contact, skin absorption,
T UT T
EFFEC S OF AC E EXPOSURE T O PRODUC :
SKI N C T
ONT AC : Propylene oxide in contact with the skin may cause severe skin
irritation and blistering. May cause burns, ulcers and superficial scarring with prolonged
SKI N ABSORPT I ON: Propylene oxide in liquid or solution form may be absorbed
through the skin and produce toxic effects. Repeated exposure can result in significant
EYE C T
ONT AC : Propylene oxide splashed in the eye can cause severe burning,
tearing, redness, swelling and corneal burns. Propylene oxide vapors can also cause
severe eye irritation.
I NHALAT I ON: Excessive inhalation of vapors can cause nasal and respiratory
irritation, central nervous system depression, including dizziness, weakness, fatigue,
nausea, headache, possible unconsciousness and even death.
I NG I ON: I ngestion of propylene oxide can cause gastrointestinal irritation, nausea,
vomiting and diarrhea. Aspiration of propylene oxide into the lungs can cause
neumonitis which can be fatal.
EFFEC S OF C T
HRONI C EXPOSURE T O PRODUC :
SKI N C T
ONT AC : Repeated or prolonged exposure may cause delayed secondary burns.
EYE C T
ONT AC : No data on chronic effects is available.
I NHALAT I ON: Studies on animals have shown chronic effects such as growth
depression, pulmonary edema, lung and liver injury and death.
I NG I ON: Studies on animals have shown chronic effects such as loss of body
weight, gastric irritation and liver injury.
I RRI T ANC OF MAT ERI AL: Severe irritant.
Catalog # 20400 4
SENSI T I ZAT I ON: Yes.
C I ENI I
ARC NOG C T Y:
OSHA: Not classified.
AC I H: Not classified.
NT P: C lassified as anticipated human carcinogen.
I ARC : C lassified as probable human carcinogen.
T ET ROG C T Y: No tetratogenic effects have been reported.
REPRODUC I VE T OXI C T Y: Reproductive effects have been shown in experimental
animals exposed to propylene oxide.
MUT AG C T Y: DNA damage and chromosomal aberrations have been shown
in experimental animals exposed to propylene oxide.
EMER GENCY & FI R S T AI D PR OCEDUR ES
EYE EXPOSURE: I mmediately flush eyes with large amounts of water for at least 15-20
minutes, occasionally lifting upper and lower lids. Seek medical attention immediately.
SKI N EXPOSURE: Remove contaminated clothing and shoes. I mmediately wash
exposed area with large quantities of mild soap and water. Flush with lukewarm water
for at least 15 minutes. Seek prompt medical attention.
I NHALAT I ON: Remove exposed person to fresh air. I f breathing has stopped, give
artificial respiration, then oxygen if needed. Contact physician immediately.
I NG I ON: Administer one pint of lukewarm water. Do not induce vomiting; risk of
damage to lungs exceeds poisoning risk. Obtain immediate emergency medical
S PI L L , L EAK AND DI S POS AL PR OCEDUR ES
SPI LLS/LEAK PROC EDURES: Release of propylene oxide may create fire or explosion
hazard. Evacuate all nonessential personnel. Extinguish all ignition sources. C lean up
personnel must be equipped with proper protective equipment. Blanket spill with water
to reduce vapors. For small spills, absorb liquid with vermiculite and place into
containers for later disposal. Do not use clay based absorbents.
DI SPOSAL MET HODS: C ontaminated solids should be landfilled only at properly
permitted disposal sites using registered contractors. Concentrated liquid waste may be
incinerated (if safety precautions are taken because of very low flash point) in
Catalog # 20400 5
compliance with applicable air pollution control regulations. I t is recommended that
contaminated product, soil or water intended for disposal be handled as hazardous
waste due to potentially low flashpoint. Disposal should be in accordance with
applicable local, State and Federal regulations.
OSHA DESI G FR
NAT I ONS: Specifically regulated substance - NO 40 C 302.4
EPA DESI G RA
NAT I ONS: RC HAZARDOUS WAST E NO: - N/A
ERC RQ: - 100 lbs (45.4 Kg)
S PECI AL PR OT ECT I ON I NFOR MAT I ON
EYE PROT EC I ON: Eye protection, including splash proof goggles and face shield,
must always be worn when the possibility exists for eye contact due to splashing or
sprayed liquid. Do not wear contact lenses.
RESPI RAT OR: Where the potential exists for exposures over 20ppm, use a MHA/NI OSH
approved, supplied air respirator with full face piece or use a NSHA/NI OSH approved
self containing breathing apparatus (SC BA) operated in positive pressure mode. Air
purifying respirators are ineffective and must not be used.
OT HER: When handling propylene oxide, wear an impervious protective suite, in
addition to gloves, boots and full head and face protection. T he equipment must be
thoroughly cleaned after each use.
VENT I LAT I ON: I nstall and operate general and local ventilation systems powerful
enough to maintain airborne levels of propylene oxide below the PEL (20ppm 8 hr
T WA). Ventilation equipment must be explosion proof.
SAFET Y ST AT I ONS: Emergency eyewash stations and safety showers should be
available in all areas of use and handling.
S PECI AL PR ECAUT I ONS
ST ORAG SEG AT
REG I ON: Store propylene oxide in a cool, properly ventilated area
away from incompatible chemicals, heat, sparks, open flame and strong oxidizing
agents. Store only in highly closed containers. Outside or detached storage is
Catalog # 20400 6
T RANSPORT AT I ON DAT A: FR
49 C 172.101
DOT SHI PPI NG NAME: Propylene Oxide
DOT LABEL(s): Flammable Liquid
DOT C LASS: 3
I MO LABEL: Flammable Liquid
I MO CLASS 3
UN REG ST ER: UN 1280
I /ST E:
SPEC AL HANDLI NG ORAG Preplan handling and emergency response procedures
prior to use. Protect containers from physical damage and regularly inspect them for
cracks, leaks or faulty valves. Use only non sparking tools and equipment when
opening and closing containers. C ontainer and system must be electrically grounded
before unloading. Dry inert gas blanketing should be used to reduce possibility of
flammable vapor mixtures in storage. Store in accordance with 29 C 1910.106.
ENG NEERI NG C ONT ROLS: All engineering systems should be of appropriate explosion
proof design (e.g. NEC Standards, NFPA, etc). Propylene oxide must be used in closed
engineering systems because of its flammability/ explosibility hazard. T his prevents
dispersion of this highly flammable gas into work area.
ST AT E REGULAT ORY I NFORMAT I ON:
ST AT E RI G T O KNOW:
California: T his product contains one or more chemicals known to the State of
California to cause cancer, birth defects or other reproductive harm.
Catalog # 20400 7