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Distributed Annotation System

Version 2



Allen Day, UCLA

Anthony Cox, EBI

Gregg Helt, Affymetrix

Andrew Dalke, Dalke Scientific

Lincoln Stein, CSHL

DAS/1



Annotation Server Reference Server Annotation Server Annotation Server









AC003027 M10154 AC003027 M10154

AC005122 AC005122

WI1029 AFM820 AFM1126 WI443

EnsEMBL 1

EnsEMBL 2

Deficiencies of DAS/1

 Format for representing genomic

features too rigid.

 Description of genomic features too

flexible.

 No IDs for genomic features.

 No write-back.

DAS/2

 Less Rigid

 Multiple formats for representing

genomic features.

 Arbitrary nesting of features..

 DAS/2 More Rigid

 Uses Sequence Ontology (SO) for

describing features

 Ready to accept attribute ontologies

 Add your own ontology, but publish it!

REST-Style IDs

 Addressing a Data Source

 http://wormbase.org/das/genome/wormbase/1

 Addressing a Feature Type

 http://wormbase.org/das/genome/wormbase/1

/type/tRNA

 Addressing a Feature

 http://wormbase.org/das/genome/wormbase/1

/feature/gene0038

Write-Back

 PUT

http://wormbase.org/das/wormbase/1/genome/feature/M7.1

 Update identified feature

 POST http://wormbase.org/das/wormbase/1/genome/feature

 Create feature

 DELETE

http://wormbase.org/das/wormbase/1/genome/feature/M7.1

 Delete feature

Progress

 Draft spec up and ready for comments

 http://www.biodas.org

 Server prototype up and running

 See Allen Day

 Client prototype up and running

 See Gregg Helt

 Project still in flux



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