CLASS SYLLABUS BASIC TOXICOLOGY ENVM 504 Credit – 3 hrs. HOUSEKEEPING DETAILS Charles D. Hébert, Ph.D., DABT None. If you need to meet me outside class, call me on my cell phone, and we can arrange a place and time to meet. Phone 492-8561 (cell) Classroom ScienCenter Room 213 Text Casarett and Doull’s Toxicology, The Basic Science of Poisons (6th Ed.) C. D. Klaassen, Ed. Available in campus bookstore or on-line (e.g., Amazon.com) Class meets on Wednesday evenings, 6:00-10:00. Generally, we’ll take a couple short breaks in the middle. I’ll be happy to answer any questions during these breaks. Attached Note that there will be no class on November 21 (Thanksgiving Break). Grades will be determined based on the following: 3 lecture exams You’ll be allowed to drop one of these three grades. Each of the others will count as 30% of the total grade; Each of these exams is non-comprehensive (i.e., covers only the material since the last exam 1 final exam 30% of total grade; Comprehensive Class participation 10% of total grade Grading Scale I do not use the +/- grading system, so all grades will be simple letter grades only (i.e., no A-, B+, etc.). The grading scale is as follows: A 91-100 B 81-90 C 71-80 D 61-70 F ≤60 Instructor Office
Schedule
Calendar
Grading
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STATEMENT OF LEARNING OBJECTIVES After completion of this course, the student will have a basic understanding of: 1. The principles of absorption, distribution, metabolism, and excretion of poisonous materials. 2. The physiologic and biochemical mechanisms by which many toxicants produce their adverse effects. 3. The types of toxic injury that can occur in major organ systems. 4. The principles surrounding toxicity of several major classes of toxicants that are relevant to environmental toxicology, including pesticides and metals. 5. Basic principles of risk assessment. AMERICANS WITH DISABILITIES ACT Samford University complies with Section 504 of the Rehabilitation Act and the Americans with Disabilities Act (ADA). The ADA prohibits discrimination against a “qualified individual with a disability”. A disability is defined as an impairment that substantially limits a major life activity such as walking, seeing, hearing, breathing, learning, working etc. For purposes of a post secondary environment a “qualified individual with a disability” is one who with or without accommodations can perform the essential functions of an academic program or course. Upon request, the University will make reasonable accommodations in the learning environment or in the location or way that a class is structured to enable a person with a disability equal access. Consideration shall be given to the University’s judgment as to what functions of an academic program or course is essential. The University is not required to provide a requested accommodation if it would require the removal of an essential function, a fundamental alteration of the nature of the program, require the lowering of a performance standard, would pose a direct threat to the health or safety of others or would result in a diminution in the value of the degree to be awarded. IMPORTANT DATES TO REMEMBER
October 10 October 12 October 12 October 16 Oct 24-Nov 16 October 31 November 20 November 21-23 December 11 December 12-13 December 15 Classes begin Last day to add a course(s) Deadline to submit Course Repeat form in semester repeated course is taken Last day to drop a course(s) without FINANCIAL penalty Registration for 1st & 2nd Nine-Week Spring Sessions Last day to withdraw from a course without ACADEMIC penalty Last day to completely withdraw from ALL courses in term without ACADEMIC penalty Thanksgiving Holidays; no classes meet Classes end Final Examinations Commencement
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GENERAL CLASS SCHEDULE Note that the schedule shown below is tentative, and can be modified if needed.
Session 1 Date Oct 10 Topics Origin and Scope of Toxicology Principles of Toxicology Absorption, Distribution, Metabolism, and Excretion (ADME) Biotransformation, Cytochrome P450 System, Phase I and Phase II Enzymes CHAPTER TEST 1 (Covers Classes 1 & 2) Toxicokinetics Toxicity Testing Non-Organ-Directed Toxicity Toxicology of the Liver CHAPTER TEST 2 (Covers Classes 4 & 5) Toxicology of the Kidney Toxicology of the Nervous System Toxicology of the Respiratory System Toxicology of Metals NO CLASS (THANKSGIVING BREAK) CHAPTER TEST 3 (Covers Classes 6 & 7) Toxicology of Pesticides Toxins of Plant and Animal Origin (Maybe) Risk Assessment FINAL EXAM (Covers Classes 1-8) Reading Assignment (Chapters) 1 2 5 6
2
Oct 17
3
Oct 24
7 None 8, 9, 10 13
4
Oct 31
5
Nov 7
14 16 15 23
6
Nov 14
--7
Nov 21 Nov 28
22 26,27 4
8 9
Dec 4 Dec 11
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